GDH/6PGL endoplasmic bifunctional protein

A GDH/6PGL endoplasmic bifunctional protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95479]

Synonyms

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rucaparib	Homo sapiens (human)	IC50	18.0000	1	2

Enables

This protein enables 7 target(s):

Target	Category	Definition
glucose-6-phosphate dehydrogenase activity	molecular function	Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. [EC:1.1.1.49]
6-phosphogluconolactonase activity	molecular function	Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+. [EC:3.1.1.31, RHEA:12556]
carbohydrate binding	molecular function	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]
glucose 1-dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH. [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN]
glucose 1-dehydrogenase (NADP+) activity	molecular function	Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH. [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN]
glucose 1-dehydrogenase [NAD(P)] activity	molecular function	Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H. [EC:1.1.1.47]
NADP binding	molecular function	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
pentose-phosphate shunt, oxidative branch	biological process	The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY]
response to nutrient levels	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]
response to alcohol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. [GOC:pr, PMID:24014527]
regulation of cortisol biosynthetic process	biological process	Any process that modulates the frequency, rate or extent of cortisol biosynthetic process. [GOC:obol, GOC:yaf]
glucose metabolic process	biological process	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]