REST corepressor 1

A REST corepressor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKL0]

Protein CoREST

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
N5-(2-chloro-6-phenoxybenzyl)-1H-1,2,4-triazole-3,5-diamine	Homo sapiens (human)	IC50	1.1600	3	3
mdl 72527	Homo sapiens (human)	IC50	100.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
polymyxin b(1)	Homo sapiens (human)	Kd	0.4630	1	1

This protein enables 4 target(s):

Target	Category	Definition
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
transcription corepressor activity	molecular function	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]

This protein is located in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

This protein is part of 4 target(s):

Target	Category	Definition
transcription repressor complex	cellular component	A protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]
DNA repair complex	cellular component	A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]
histone deacetylase complex	cellular component	A protein complex that possesses histone deacetylase activity. [GOC:mah]
transcription regulator complex	cellular component	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]

This protein is involved in 6 target(s):

Target	Category	Definition
chromatin organization	biological process	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
erythrocyte differentiation	biological process	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. [GOC:mah]
positive regulation of megakaryocyte differentiation	biological process	Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. [GOC:go_curators]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]