1-(3-4-dihydroxyphenyl)-2-thiocyanate-ethanone and Ischemia

1-(3-4-dihydroxyphenyl)-2-thiocyanate-ethanone has been researched along with Ischemia* in 1 studies

Other Studies

1 other study(ies) available for 1-(3-4-dihydroxyphenyl)-2-thiocyanate-ethanone and Ischemia

Article	Year
The protective effect of a newly developed molecular chaperone-inducer against mouse ischemic acute kidney injury. Journal of pharmacological sciences, 2009, Volume: 109, Issue:2 Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury. Topics: Animals; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Ischemia; Kidney; Male; Mice; Mice, Inbred Strains; Molecular Chaperones; Reperfusion Injury; RNA, Messenger; Thiocyanates; Transcriptional Activation; Tunicamycin; Up-Regulation	2009

Article

Year

The protective effect of a newly developed molecular chaperone-inducer against mouse ischemic acute kidney injury.

Journal of pharmacological sciences, 2009, Volume: 109, Issue:2

Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.

Topics: Animals; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Ischemia; Kidney; Male; Mice; Mice, Inbred Strains; Molecular Chaperones; Reperfusion Injury; RNA, Messenger; Thiocyanates; Transcriptional Activation; Tunicamycin; Up-Regulation

2009