spironolactone has been researched along with Ischemia in 9 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with spironolactone either before or after ischemia prevented subsequent CKD by avoiding the activation of fibrotic and inflammatory pathways." | 5.39 | Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury. ( Barrera-Chimal, J; Bobadilla, NA; Gamba, G; Pérez-Villalva, R; Reyna, J; Rodríguez-Romo, R; Uribe, N, 2013) |
| " Therefore, we investigate whether the selective mineralocorticoid receptor (MR) antagonist eplerenone improves EPCs function in rat hindlimb ischemia." | 3.76 | Effect of eplerenone on endothelial progenitor cells and oxidative stress in ischemic hindlimb. ( Fukuda, N; Fukushima, H; Hirata, H; Ishimitsu, T; Kobayashi, E; Kobayashi, N; Koguchi, W; Machida, Y; Mamada, Y; Suzuki, N; Tabei, K; Takeshima, H; Yokotsuka, F, 2010) |
| "Spironolactone treatment immediately or 1." | 1.42 | Mild ischemic injury leads to long-term alterations in the kidney: amelioration by spironolactone administration. ( Barrera-Chimal, J; Bobadilla, NA; Durand, M; Jaisser, F; Ortega, JA; Pérez-Villalva, R; Rodríguez-Romo, R; Sánchez, A, 2015) |
| "Treatment with spironolactone either before or after ischemia prevented subsequent CKD by avoiding the activation of fibrotic and inflammatory pathways." | 1.39 | Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury. ( Barrera-Chimal, J; Bobadilla, NA; Gamba, G; Pérez-Villalva, R; Reyna, J; Rodríguez-Romo, R; Uribe, N, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Dragasevic, N | 1 |
| Savic, M | 1 |
| Mihajlovic, K | 1 |
| Zivkovic, V | 1 |
| Andjic, M | 1 |
| Draginic, N | 1 |
| Zdravkovic, N | 1 |
| Bolevich, S | 2 |
| Jakovljevic, V | 1 |
| Nikolic Turnic, T | 1 |
| Barrera-Chimal, J | 4 |
| Bobadilla, NA | 4 |
| Chou, YH | 1 |
| Lin, SL | 1 |
| Pérez-Villalva, R | 3 |
| Ortega, JA | 1 |
| Sánchez, A | 1 |
| Rodríguez-Romo, R | 2 |
| Durand, M | 1 |
| Jaisser, F | 1 |
| Kobayashi, N | 1 |
| Fukushima, H | 1 |
| Takeshima, H | 1 |
| Koguchi, W | 1 |
| Mamada, Y | 1 |
| Hirata, H | 1 |
| Machida, Y | 1 |
| Suzuki, N | 1 |
| Yokotsuka, F | 1 |
| Tabei, K | 1 |
| Kobayashi, E | 1 |
| Fukuda, N | 1 |
| Ishimitsu, T | 1 |
| Cortés-González, C | 1 |
| Ojeda-Cervantes, M | 1 |
| Gamba, G | 2 |
| Morales-Buenrostro, LE | 1 |
| Reyna, J | 1 |
| Uribe, N | 1 |
| Markov, KhM | 1 |
| Ivanova, IA | 1 |
| Stefan, H | 1 |
| Helge, H | 1 |
| Merker, HJ | 1 |
| Bachmann, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Non Randomised Controlled Trial of Short Term Spironolactone Use for Prevention of Acute Kidney Injury After Cardiac Surgery[NCT02417896] | 150 participants (Anticipated) | Interventional | 2013-04-30 | Recruiting | |||
| Usefulness of Spironolactone for the Prevention of Acute Kidney Injury in Critically Ill Patients With Invasive Mechanical Ventilation[NCT03206658] | Phase 3 | 90 participants (Anticipated) | Interventional | 2017-08-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for spironolactone and Ischemia
| Article | Year |
|---|---|
The impact of different diuretics on regression of myocardial reperfusion injury in spontaneously hypertensive rats.
Topics: Animals; Diuretics; Hydrochlorothiazide; Indapamide; Ischemia; Male; Myocardial Reperfusion; Myocard | 2023 |
The authors reply.
Topics: Acute Kidney Injury; Animals; Ischemia; Male; Renal Insufficiency, Chronic; Spironolactone | 2013 |
How to confirm the specific effect of spironolactone in chronic kidney disease caused by ischemic acute kidney injury?
Topics: Acute Kidney Injury; Animals; Ischemia; Male; Renal Insufficiency, Chronic; Spironolactone | 2013 |
Mild ischemic injury leads to long-term alterations in the kidney: amelioration by spironolactone administration.
Topics: Animals; Ischemia; Kidney; Male; Proteinuria; Rats; Rats, Wistar; Reperfusion Injury; Spironolactone | 2015 |
Effect of eplerenone on endothelial progenitor cells and oxidative stress in ischemic hindlimb.
Topics: Angiopoietin-1; Angiopoietin-2; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive A | 2010 |
Hsp72 is an early and sensitive biomarker to detect acute kidney injury.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Creatine; Hepatitis A Virus Cellular | 2011 |
Hsp72 is an early and sensitive biomarker to detect acute kidney injury.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Creatine; Hepatitis A Virus Cellular | 2011 |
Hsp72 is an early and sensitive biomarker to detect acute kidney injury.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Creatine; Hepatitis A Virus Cellular | 2011 |
Hsp72 is an early and sensitive biomarker to detect acute kidney injury.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Creatine; Hepatitis A Virus Cellular | 2011 |
Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury.
Topics: Acute Kidney Injury; Animals; Collagen Type I; Disease Models, Animal; Diuretics; Dose-Response Rela | 2013 |
[Role of aldosterone in the initial stage of 2 forms of experimental vasorenal hypertension].
Topics: Aldosterone; Animals; Blood Pressure; Hypertension, Renal; Ischemia; Kidney; Ligation; Male; Mineral | 1975 |
[Kidney artery stenosis, renal hypertension and secondary hyperaldosteronism in an 8-year-old boy. (Stunted growth through potassium deficiency)].
Topics: Adrenal Glands; Aldosterone; Child; Dwarfism; Humans; Hyperaldosteronism; Hypertension, Renal; Hypok | 1968 |