fg-4592 and Ischemia

fg-4592 has been researched along with Ischemia* in 2 studies

Other Studies

2 other study(ies) available for fg-4592 and Ischemia

ArticleYear
Roxadustat (FG-4592) protects against ischaemia/reperfusion-induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice.
    Clinical and experimental pharmacology & physiology, 2022, Volume: 49, Issue:2

    Ischaemia-reperfusion (I/R) is one of the main factors of acute kidney injury (AKI). mitochondrial damage pathway are important features of I/R induced-acute kidney injury (IRI-AKI). Hypoxia-inducible factor (HIF) expression in renal tubule segments is up-regulated during AKI. Herein, we investigated the role of FG-4592 in a mouse model of IRI-AKI to confirm whether FG-4592 is beneficial in AKI. We found that pretreatment with FG-4592 significantly ameliorated renal function and renal histological damage in mice after IRI. Furthermore, these results suggest that pretreatment with FG-4592 significantly reduced the tubular cells apoptosis (decreased TUNEL-positive cells, Bax, caspase12 levels), attenuated mitochondrial damage (increased ATPβ, PPARγ, mitochondrial DNA copy number, and decreased cytoplasmic cytochrome C), and alleviated DNA damage after IRI. In conclusion, pretreatment with FG-4592 may effectively prevent kidney from IRI possibly by via diminishing tubular cells injuries and protection of mitochondrial damage pathway. These results further validate that FG-4592 may be an effective drug in the clinical treatment of IRI-AKI.

    Topics: Acute Kidney Injury; Animals; Apoptosis; Glycine; Ischemia; Isoquinolines; Kidney; Mice; Mice, Inbred C57BL; Reperfusion; Reperfusion Injury

2022
Can Pharmacological Ischemic Preconditioning Affect Myocardial Ischemic Injury?
    Circulation journal : official journal of the Japanese Circulation Society, 2020, 05-25, Volume: 84, Issue:6

    Topics: Animals; Glycine; Ischemia; Ischemic Preconditioning, Myocardial; Isoquinolines; Mice; Myocardial Reperfusion Injury

2020