chlorpromazine has been researched along with Ischemia in 54 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury." | 7.83 | Influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. ( Brenny, T; Czeczko, NG; Foiatto, JC; Gomes, RP; Malafaia, O; Oliveira, AM; Wietzikoski, EG, 2016) |
| "The effects of treatment with chlorpromazine (4 mg/kg) and phenoxybenzamine (1 and 5 mg/kg) on renal function and morphology after warm ischemia and contralateral nephrectomy were studied." | 7.66 | Recovery of renal function after warm ischemia. I. The effect of chlorpromazine and phenoxybenzamine. ( Birrell, C; Howden, B; Jablonski, P; Leslie, E; Marshall, VC; Rae, D; Tange, J, 1983) |
| "In both the CPZ-treated and nontreated groups, ischemia induced a decline in muscle glycogen content, with a corresponding increase in muscle lactate and a decrease in mitochondrial respiratory control ratio." | 5.32 | Lack of chlorpromazine effect on skeletal muscle metabolism after ischemia and a short reperfusion period. ( Cherri, J; Massuda, CA; Piccinato, CE; Salles Roselino, JE, 2004) |
| "To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury." | 3.83 | Influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. ( Brenny, T; Czeczko, NG; Foiatto, JC; Gomes, RP; Malafaia, O; Oliveira, AM; Wietzikoski, EG, 2016) |
| "To evaluate the influence of chlorpromazine (CPZ) on renal function and lipid peroxidation in a rat model of kidney ischemia/reperfusion injury." | 3.74 | Renal ischemia and reperfusion injury: influence of chorpromazine on renal function and lipid peroxidation. ( Carvalho, RM; Celini, FM; Cologna, AJ; Martins, AC; Suaid, HJ; Tirapelli, LF; Tucci Junior, S, 2008) |
| "The effects of chlorpromazine, an agent with inhibitory effects of calcium influx, phospholipase activation, and Na-K-ATPase, on preserving renal function and proximal tubular ultrastructure were evaluated in renal ischemia." | 3.67 | Effects of chlorpromazine on ischemic rat kidney: a functional and ultrastructural study. ( Chou, SY; Jayachandran, S; Kim, H; Mooppan, MM, 1985) |
| "The effects of treatment with chlorpromazine (4 mg/kg) and phenoxybenzamine (1 and 5 mg/kg) on renal function and morphology after warm ischemia and contralateral nephrectomy were studied." | 3.66 | Recovery of renal function after warm ischemia. I. The effect of chlorpromazine and phenoxybenzamine. ( Birrell, C; Howden, B; Jablonski, P; Leslie, E; Marshall, VC; Rae, D; Tange, J, 1983) |
| "The effect of chlorpromazine pretreatment of kidneys then damaged by warm ischemia was investigated." | 3.66 | Renographic evaluation of kidney preservation with chlorpromazine. ( Bilde, T; Dahlager, JI, 1979) |
| "In both the CPZ-treated and nontreated groups, ischemia induced a decline in muscle glycogen content, with a corresponding increase in muscle lactate and a decrease in mitochondrial respiratory control ratio." | 1.32 | Lack of chlorpromazine effect on skeletal muscle metabolism after ischemia and a short reperfusion period. ( Cherri, J; Massuda, CA; Piccinato, CE; Salles Roselino, JE, 2004) |
| "Chlorpromazine was effective despite reduction of blood pressure, and trifluoperazine did not alter blood pressure." | 1.28 | Phenothiazines reduce ischemic damage to the central nervous system. ( Kochhar, A; Saitoh, T; Zivin, JA, 1989) |
| " Both had received a commonly used psychotropic drug in large dosage before the acute episode." | 1.27 | Ischaemic colitis associated with psychotropic drugs. ( Gollock, JM; Thomson, JP, 1984) |
| "Chlorpromazine treatment prevents the irreversible lesion from taking place." | 1.26 | Effect of a transitory ischaemia on the structure-linked latency of rat liver acid phosphatase and beta-galactosidase. ( Wattianx-De Coninck, S; Wattiaux, R, 1981) |
| "Chlorpromazine treated and untreated groups of animals were compared, the results obtained were identical in both groups." | 1.26 | The effect of chlorpromazine pretreatment on tubular function in kidney preservation. ( Bilde, T; Dahlager, JI, 1976) |
| "Chlorpromazine pretreatment improved survival." | 1.26 | The effect of chlorpromazine pretreatment on renal function and pathology in kidneys damaged by warm ischaemia. ( Asnaes, S; Bilde, T; Dahlager, JI; Jaglicic, D, 1977) |
| "Chlorpromazine 3." | 1.26 | The effect of chlorpromazine pretreatment on the vascular resistance in kidneys following warm ischaemia. ( Bilde, T; Dahlager, JI, 1977) |
| "Pretreatment with chlorpromazine (20 mg/kg) 30 minutes before inducing ischemia for up to 3 hours virtually completely prevented this ischemic cell death." | 1.26 | Prevention by chlorpromazine of ischemic liver cell death. ( Abrams, J; Chien, KR; Farber, JL; Pfau, RG, 1977) |
| "Pretreatment with chlorpromazine and heparin did not affect the final results." | 1.26 | The effect of chlorpromazine and heparin pretreatment on kidney viability and function after warm ischaemic damage. ( Asnaes, S; Bilde, T; Dahlager, JI; Jaglicic, D, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (92.59) | 18.7374 |
| 1990's | 1 (1.85) | 18.2507 |
| 2000's | 2 (3.70) | 29.6817 |
| 2010's | 1 (1.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Foiatto, JC | 1 |
| Czeczko, NG | 1 |
| Wietzikoski, EG | 1 |
| Malafaia, O | 1 |
| Brenny, T | 1 |
| Oliveira, AM | 1 |
| Gomes, RP | 1 |
| Tucci Junior, S | 1 |
| Carvalho, RM | 1 |
| Celini, FM | 1 |
| Cologna, AJ | 1 |
| Suaid, HJ | 1 |
| Tirapelli, LF | 1 |
| Martins, AC | 1 |
| WIEMERS, K | 1 |
| KANIAK, EG | 1 |
| PISKORZ, A | 1 |
| BOWBELSKA, I | 1 |
| SCULTETY, S | 1 |
| JAKI, J | 1 |
| BACHRACH, D | 1 |
| KORPASSY, B | 1 |
| JILEK, L | 1 |
| TROJAN, S | 1 |
| Piccinato, CE | 1 |
| Salles Roselino, JE | 1 |
| Massuda, CA | 1 |
| Cherri, J | 1 |
| Selye, H | 3 |
| Pahk, US | 1 |
| Somogyi, A | 2 |
| Gollock, JM | 1 |
| Thomson, JP | 1 |
| Wattiaux, R | 3 |
| Wattianx-De Coninck, S | 1 |
| Pavlock, GS | 1 |
| Southard, JH | 1 |
| Lutz, MF | 1 |
| Belzer, JP | 1 |
| Belzer, FO | 1 |
| Wattiaux-De Coninck, S | 2 |
| Dubois, F | 1 |
| Jablonski, P | 1 |
| Howden, B | 1 |
| Leslie, E | 1 |
| Rae, D | 1 |
| Birrell, C | 1 |
| Marshall, VC | 1 |
| Tange, J | 1 |
| Kuniyoshi, M | 1 |
| Bilde, T | 7 |
| Dahlager, JI | 7 |
| Chatterjee, SN | 1 |
| Petritsch, PH | 2 |
| Green, RD | 1 |
| Boyer, D | 1 |
| Halasz, NA | 1 |
| Collins, GM | 1 |
| Mittnacht, S | 1 |
| Sherman, SC | 1 |
| Farber, JL | 3 |
| Stevens, D | 1 |
| Stegall, B | 1 |
| Chien, KR | 2 |
| Abrams, J | 2 |
| Serroni, A | 1 |
| Martin, JT | 1 |
| Asnaes, S | 2 |
| Jaglicic, D | 2 |
| Pfau, RG | 1 |
| Valdes, ME | 1 |
| Lokkegaard, H | 1 |
| Patel, YJ | 1 |
| Scherl, ND | 1 |
| Elias, S | 1 |
| Chessler, RK | 1 |
| Zingler, BM | 1 |
| Zivin, JA | 1 |
| Kochhar, A | 1 |
| Saitoh, T | 1 |
| Slezák, J | 2 |
| Tribulová, N | 1 |
| Gabauer, I | 1 |
| Ziegelhöffer, A | 1 |
| Holec, V | 1 |
| Cheung, JY | 1 |
| Bonventre, JV | 1 |
| Malis, CD | 1 |
| Leaf, A | 1 |
| Jayachandran, S | 1 |
| Mooppan, MM | 1 |
| Chou, SY | 1 |
| Kim, H | 1 |
| Maxwell, DR | 2 |
| Read, MA | 2 |
| Sumpter, EA | 1 |
| Polizzi, M | 3 |
| Bartoli, GM | 2 |
| Gaudiano, A | 3 |
| Montorsi, F | 1 |
| Petti, G | 3 |
| Tartarini, S | 2 |
| Geschickter, CF | 1 |
| Aronson, RS | 1 |
| Geschickter, EH | 1 |
| Jensen, EH | 1 |
| Kemp, E | 1 |
| Bell, PR | 1 |
| Quin, RO | 1 |
| Calman, KC | 1 |
| Mozes, MF | 1 |
| Toledo-Pereyra, LH | 2 |
| Campos, RA | 1 |
| Moberg, AW | 1 |
| Najarian, JS | 2 |
| Lambotte, L | 1 |
| Simmons, RL | 1 |
| Draz, S | 1 |
| Minami, R | 1 |
| Byrield, J | 1 |
| Fonkalsrud, EW | 1 |
| Broch, E | 1 |
| Netkovszky, K | 1 |
| Severini, G | 1 |
| Matsushita, A | 1 |
| Smith, CM | 1 |
| Conner, AN | 1 |
| Kositskiĭ, GI | 1 |
| El'gort, PE | 1 |
| Largiadèr, F | 1 |
2 reviews available for chlorpromazine and Ischemia
| Article | Year |
|---|---|
Pharmacologic agents of potential value in protecting kidneys from ischemic damage.
Topics: Adrenal Cortex Hormones; Allopurinol; Animals; Chlorpromazine; Dogs; Glutathione; Humans; Ischemia; | 1977 |
Calcium and ischemic injury.
Topics: Animals; Calcium; Calcium Channel Blockers; Chlorpromazine; Cytosol; Extracellular Space; Homeostasi | 1986 |
52 other studies available for chlorpromazine and Ischemia
| Article | Year |
|---|---|
Influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury.
Topics: Animals; Chlorpromazine; Disease Models, Animal; Ischemia; Ischemic Preconditioning; Kidney; Kidney | 2016 |
Renal ischemia and reperfusion injury: influence of chorpromazine on renal function and lipid peroxidation.
Topics: Animals; Biomarkers; Chlorpromazine; Creatinine; Disease Models, Animal; Dopamine Antagonists; Ische | 2008 |
[Effects of chlorpromazine on survival and recovery time of the rabbit brain in acute ischemia].
Topics: Animals; Brain; Chlorpromazine; Ischemia; Rabbits | 1954 |
[Effect of hypothermia induced by largactil on acute ischemia of the extremities].
Topics: Body Temperature; Chlorpromazine; Hypothermia; Ischemia; Peripheral Vascular Diseases; Vascular Dise | 1955 |
The influence of drugs (largactil, hydergin and pendiomid) in experimental traumatic renal ischaemia; a preliminary report.
Topics: Autonomic Agents; Chlorpromazine; Humans; Ischemia; Kidney; Kidney Diseases | 1956 |
[Influences on resistance of the body against oligemia and ischemia of the CNS during the course of ontogenesis].
Topics: Aging; Central Nervous System; Chlorpromazine; Hyperglycemia; Hypoxia; Ischemia; Pentobarbital | 1963 |
Lack of chlorpromazine effect on skeletal muscle metabolism after ischemia and a short reperfusion period.
Topics: Animals; Chlorpromazine; Disease Models, Animal; Dogs; Glycogen; Hydrogen-Ion Concentration; Ischemi | 2004 |
Prevention of renal necrosis by stress.
Topics: Animals; Chlorpromazine; Cyproheptadine; Ischemia; Kidney Diseases; Necrosis; Rats; Stress, Physiolo | 1967 |
Ischaemic colitis associated with psychotropic drugs.
Topics: Amitriptyline; Chlorpromazine; Colitis; Colon; Female; Humans; Ischemia; Middle Aged | 1984 |
Effect of a transitory ischaemia on the structure-linked latency of rat liver acid phosphatase and beta-galactosidase.
Topics: Acid Phosphatase; Animals; beta-Galactosidase; Centrifugation; Chlorpromazine; Galactosidases; Ische | 1981 |
Effects of mannitol and chlorpromazine pretreatment of rabbits on kidney mitochondria following in vivo ischemia and reflow.
Topics: Adenosine Diphosphate; Animals; Chlorpromazine; Female; Ischemia; Kidney; Kinetics; Male; Mannitol; | 1981 |
Prevention by chlorpromazine of lysosomal enzyme release caused by a transitory ischaemia. Effect of hypothermia.
Topics: Acid Phosphatase; Animals; beta-Galactosidase; Chlorpromazine; Cold Temperature; Ischemia; Lysosomes | 1982 |
Recovery of renal function after warm ischemia. I. The effect of chlorpromazine and phenoxybenzamine.
Topics: Animals; Chlorpromazine; Creatinine; Dose-Response Relationship, Drug; Glomerular Filtration Rate; I | 1983 |
[Study on renal transplantation. VII. Experimental study on protective effect of chlorpromazine on damage of the warm ischemic kidney (author's transl)].
Topics: Aged; Angiography; Animals; Chlorpromazine; Humans; Ischemia; Kidney; Kidney Transplantation; Organ | 1980 |
The effect of chlorpromazine pretreatment on the vascular function of kidneys damaged by warm ischaemia and cold storage in Collins' solution.
Topics: Animals; Chlorpromazine; Cold Temperature; Ischemia; Kidney; Organ Preservation; Organ Size; Rabbits | 1980 |
Reversible and irreversible alterations of lysosomes in ischemic rat-liver. Effects of chlorpromazine.
Topics: Acid Phosphatase; Animals; Chlorpromazine; Galactosidases; Hydrolases; Ischemia; Liver; Lysosomes; M | 1980 |
[Pathophysiology of kidney lesions after temporary ischemia and measures for their prevention].
Topics: Animals; Chlorpromazine; Creatinine; Dogs; Edema; Electrolytes; Furosemide; Heparin; Hypothermia; Is | 1979 |
Renographic evaluation of kidney preservation with chlorpromazine.
Topics: Animals; Chlorpromazine; Female; Iodine Radioisotopes; Iodohippuric Acid; Ischemia; Kidney; Kidney C | 1979 |
Pharmacological protection of rabbit kidneys from normothermic ischemia.
Topics: Animals; Body Temperature; Chlorpromazine; Dopamine; Female; Furosemide; Ischemia; Kidney; Male; Man | 1979 |
Reversal of ischemic mitochondrial dysfunction.
Topics: Animals; Chlorpromazine; Cytochromes; Female; Ischemia; Liver; Mitochondria, Liver; Mitochondrial AD | 1979 |
Post-dopamine ischemia treated with chlorpromazine.
Topics: Aged; Chlorpromazine; Dopamine; Extremities; Humans; Ischemia; Male | 1978 |
Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury.
Topics: Animals; Calcium; Chlorpromazine; Female; Ischemia; Liver; Microsomes, Liver; Permeability; Phosphol | 1978 |
The effect of chlorpromazine pretreatment on tubular function in kidney preservation.
Topics: Animals; Chlorpromazine; Cold Temperature; Hot Temperature; Iodohippuric Acid; Ischemia; Kidney; Kid | 1976 |
[Pathophysiological damage to the kidney due to temporary ischemia and measures to avoid these changes (author's transl)].
Topics: Animals; Chlorpromazine; Creatinine; Dogs; Female; Furosemide; Heparin; Ischemia; Kidney; Kidney Tra | 1976 |
The effect of chlorpromazine pretreatment on renal function and pathology in kidneys damaged by warm ischaemia.
Topics: Animals; Blood Pressure; Chlorpromazine; Female; Ischemia; Kidney; Kidney Diseases; Mortality; Nephr | 1977 |
The effect of chlorpromazine pretreatment on the vascular resistance in kidneys following warm ischaemia.
Topics: Animals; Blood Pressure; Chlorpromazine; Hypothermia, Induced; Injections, Intravenous; Ischemia; Ki | 1977 |
Prevention by chlorpromazine of ischemic liver cell death.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane; Cell Survival; Chlorpromazine; Female; Isch | 1977 |
The effect of chlorpromazine and heparin pretreatment on kidney viability and function after warm ischaemic damage.
Topics: Animals; Chlorpromazine; Creatinine; Female; Heparin; Ischemia; Kidney; Nephrectomy; Rabbits; Renal | 1977 |
Post-dopamine ischemia treated with chlorpromazine.
Topics: Aged; Chlorpromazine; Dopamine; Fingers; Humans; Hypotension; Ischemia; Male | 1976 |
Experimental and clinical experience with chlorpromazine pre-treatment of donor kidneys.
Topics: Animals; Chlorpromazine; Ischemia; Kidney; Kidney Transplantation; Organ Preservation; Rabbits; Swin | 1975 |
Ischemic colitis associated with psychotropic drugs.
Topics: Adult; Chlorpromazine; Colitis; Colon; Desipramine; Female; Humans; Imipramine; Ischemia | 1992 |
Phenothiazines reduce ischemic damage to the central nervous system.
Topics: Animals; Brain Ischemia; Chlorpromazine; Ischemia; Phenothiazines; Rabbits; Spinal Cord; Trifluopera | 1989 |
Diminution of "reperfusion injury" in reperfused ischemic myocardium by phenothiazines. A quantitative morphological study.
Topics: Adenine Nucleotides; Animals; Chlorpromazine; Dogs; Female; Ischemia; Lactates; Male; Microscopy, El | 1987 |
Effects of chlorpromazine on ischemic rat kidney: a functional and ultrastructural study.
Topics: Animals; Chlorpromazine; Constriction; Creatinine; Hypothermia, Induced; Ischemia; Kidney Diseases; | 1985 |
Pharmacology of M & B 18,706, a drug which selectively reduces decerebrate rigidity.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Cats; Cerebellar Ataxia; Cerebellum; Chlorpromaz | 1974 |
[Effect of some neuroleptic drugs and antihistaminics on the changes of the enzyme pattern induced by ischemia in the rat liver].
Topics: Animals; Cathepsins; Chlorpheniramine; Chlorpromazine; Electron Transport Complex IV; Galactosidases | 1968 |
Effects of chlorpromazine on behaviour of some enzymes of rat liver in different experimental conditions.
Topics: Acid Phosphatase; Animals; Cathepsins; Chlorpromazine; Dextrans; Electron Transport Complex IV; Endo | 1969 |
Tourniquet poditis--an experimental pedal inflammation in the rat.
Topics: Animals; Anti-Bacterial Agents; Chlorpromazine; Cyproheptadine; Depression, Chemical; Dextrans; Dibe | 1969 |
Inhibition of the inflammatory response in the microcirculation by tourniquet shock and release of adrenal hormones. In vivo and electronmicroscopic observations.
Topics: Adrenal Glands; Adrenalectomy; Animals; Capillaries; Chlorpromazine; Cortisone; Edema; Egg White; Ep | 1969 |
Kidney preservation. II. Liberation of enzymes and urea from preserved kidneys.
Topics: Animals; Chlorpromazine; Female; Ischemia; Kidney; Kidney Transplantation; L-Lactate Dehydrogenase; | 1972 |
Donor pretreatment and organ preservation.
Topics: Animals; Chlorpromazine; Coronary Vessels; Furosemide; Heart Transplantation; Heparin; Ischemia; Kid | 1974 |
Prevention of irreversible ischemic damage in renal preservation by pharmacological manipulation.
Topics: Allopurinol; Animals; Chlorpromazine; Dogs; Hypothermia; Ischemia; Kidney Transplantation; Methylpre | 1974 |
The effects of some drugs on the rigidity of the cat due to ischaemic or intercollicular decerebration.
Topics: Acepromazine; Animals; Carisoprodol; Cats; Cerebrovascular Circulation; Chlorpromazine; Decerebrate | 1972 |
Use of hepatic cell membrane potential measurement to evaluate new method of liver preservation.
Topics: Acid Phosphatase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Membrane; Cell Me | 1973 |
Comparative effects of chlorpromazine, methylprednisolone, and allopurinol during small bowel preservation.
Topics: Allopurinol; Animals; Chlorpromazine; Dogs; Injections, Intravenous; Intestine, Small; Ischemia; Met | 1973 |
Biochemical evaluation of hepatic preservation techniques in the isolated rat liver.
Topics: Acid Phosphatase; Acid-Base Equilibrium; Alanine Transaminase; Animals; Buffers; Chlorpromazine; Glu | 1971 |
[Action of some drugs on experimental liver necrosis].
Topics: Animals; Chlorpromazine; Cysteine; Injections, Intraperitoneal; Ischemia; Liver Diseases; Necrosis; | 1971 |
Ischemic necrosis: prevention by stress.
Topics: Animals; Chlorpromazine; Cold Temperature; Cordotomy; Epinephrine; Female; Hydrocortisone; Ischemia; | 1967 |
Muscle relaxants on postischemic spinal rigidity in the rat.
Topics: Animals; Chlorpromazine; Contracture; Decerebrate State; Depression, Chemical; Electromyography; Hin | 1970 |
Prolonged external pressure as a cause of eschaemic contracture.
Topics: Adult; Alcoholism; Atropine; Barbiturates; Chlorpromazine; Contracture; Female; Forearm; Humans; Isc | 1971 |
[Reactions of the blood system during short-term disturbances of the coronary circulation].
Topics: Adrenalectomy; Animals; Blood Cell Count; Blood Sedimentation; Chlorpromazine; Constriction; Coronar | 1967 |
[Tissue preservation].
Topics: Adrenochrome; Cell Membrane; Cell Membrane Permeability; Chlorpromazine; Fluorenes; Freezing; Heart; | 1968 |