1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Ischemia in 12 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study was dedicated to investigating the vascular protective potential of Fasudil, a ROCK inhibitor, on an experimentally induced unilateral critical limb ischemia (CLI) model in mice and demonstrated the possible underlying mechanisms." | 8.12 | Fasudil, a ROCK inhibitor, preserves limb integrity in a mouse model of unilateral critical limb ischemia: Possible interplay of inflammatory and angiogenic signaling pathways. ( El-Waseif, AG; Elshaer, SL; Nader, MA; Salem, HA, 2022) |
| "The aim of this study is to evaluate the role of Rho-kinase in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion (I/R) and the preconditioning effects of fasudil hydrochloride." | 7.77 | Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. ( Fan, Z; Hu, XW; Huang, L; Jing, HR; Li, Y; Liu, KX; Tian, XF; Yao, JH, 2011) |
| "Retinal ischemia was induced by increasing the intraocular pressure to 100 mmHg for 60 min." | 5.37 | Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. ( Gao, D; Song, H, 2011) |
| "The current study was dedicated to investigating the vascular protective potential of Fasudil, a ROCK inhibitor, on an experimentally induced unilateral critical limb ischemia (CLI) model in mice and demonstrated the possible underlying mechanisms." | 4.12 | Fasudil, a ROCK inhibitor, preserves limb integrity in a mouse model of unilateral critical limb ischemia: Possible interplay of inflammatory and angiogenic signaling pathways. ( El-Waseif, AG; Elshaer, SL; Nader, MA; Salem, HA, 2022) |
| "To investigate the effect of fasudil, a Rho-kinase inhibitor, on chronic ischemia-related bladder dysfunction." | 3.88 | Protective Effect of a Rho-kinase Inhibitor on Bladder Dysfunction in a Rat Model of Chronic Bladder Ischemia. ( Aikawa, K; Akaihata, H; Haga, N; Hata, J; Ishibashi, K; Koguchi, T; Kojima, Y; Kushida, N; Matsuoka, K; Nomiya, M, 2018) |
| "The aim of this study is to evaluate the role of Rho-kinase in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion (I/R) and the preconditioning effects of fasudil hydrochloride." | 3.77 | Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. ( Fan, Z; Hu, XW; Huang, L; Jing, HR; Li, Y; Liu, KX; Tian, XF; Yao, JH, 2011) |
| "Retinal ischemia was induced by increasing the intraocular pressure to 100 mmHg for 60 min." | 1.37 | Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. ( Gao, D; Song, H, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Z | 1 |
| Qiu, B | 1 |
| Wang, Q | 1 |
| Wei, W | 1 |
| Huang, J | 1 |
| Duan, W | 1 |
| El-Waseif, AG | 1 |
| Nader, MA | 1 |
| Salem, HA | 1 |
| Elshaer, SL | 1 |
| Akaihata, H | 1 |
| Nomiya, M | 1 |
| Matsuoka, K | 1 |
| Koguchi, T | 1 |
| Hata, J | 1 |
| Haga, N | 1 |
| Kushida, N | 1 |
| Ishibashi, K | 1 |
| Aikawa, K | 1 |
| Kojima, Y | 1 |
| Wei, J | 1 |
| Wang, P | 1 |
| Li, Y | 2 |
| Dou, Q | 1 |
| Lin, J | 2 |
| Tao, W | 1 |
| Fu, X | 1 |
| Huang, Z | 1 |
| Zhang, W | 1 |
| Vasam, G | 1 |
| Joshi, S | 1 |
| Thatcher, SE | 1 |
| Bartelmez, SH | 1 |
| Cassis, LA | 1 |
| Jarajapu, YP | 1 |
| Huang, L | 2 |
| Li, Q | 1 |
| Li, H | 1 |
| He, Z | 1 |
| Cheng, Z | 1 |
| Chen, J | 1 |
| Guo, L | 1 |
| Yao, JH | 1 |
| Hu, XW | 1 |
| Fan, Z | 1 |
| Jing, HR | 1 |
| Liu, KX | 1 |
| Tian, XF | 1 |
| Song, H | 1 |
| Gao, D | 1 |
| O, E | 1 |
| Ahn, HY | 1 |
| Kim, HK | 1 |
| You, JC | 1 |
| Shin, JC | 1 |
| Joe, YA | 1 |
| Satoh, S | 1 |
| Toshima, Y | 1 |
| Ikegaki, I | 1 |
| Iwasaki, M | 1 |
| Asano, T | 1 |
| Boniece, IR | 1 |
| Wagner, JA | 1 |
| Madden, KP | 1 |
| Clark, WM | 1 |
| Kochhar, A | 1 |
| Zivin, JA | 1 |
12 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Ischemia
| Article | Year |
|---|---|
Fasudil on Myocardial Injury in Rats with Myocardial Ischemia and Reperfusion through Rho-ROCK Signal Pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Artery Disease; Humans; Ischemia; M | 2022 |
Fasudil, a ROCK inhibitor, preserves limb integrity in a mouse model of unilateral critical limb ischemia: Possible interplay of inflammatory and angiogenic signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Chronic Limb-Threatening Ische | 2022 |
Protective Effect of a Rho-kinase Inhibitor on Bladder Dysfunction in a Rat Model of Chronic Bladder Ischemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chronic Disease; Disease Models, Animal; Isc | 2018 |
Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Blotting, Western; Cytoki | 2018 |
Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin I; Animals; Blood Vessels; Bone Marrow; B | 2017 |
Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Cells, Cult | 2009 |
Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Interleukin-6; Intestines | 2011 |
Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; bcl-2-Associated X Protein; Caspase 3; Gene | 2011 |
The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Adhesion; Cell Proliferation; Cells, Cu | 2011 |
Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipyrine; Cell Death; Dose-Response Relati | 2007 |
Growth factors protect PC12 cells against ischemia by a mechanism that is independent of PKA, PKC, and protein synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anisomycin; Cell Hypoxia; Cell Su | 1993 |
Effect of protein kinase C modulation on outcome of experimental CNS ischemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Diglycerides | 1991 |