nitrites has been researched along with Ischemia in 69 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance." | 7.85 | Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m). ( Fothergill, DM; Gasier, HG; Loiselle, AR; Reinhold, AR; Soutiere, SE, 2017) |
| " During limb ischemia, decreased NO bioavailability occurs secondary to increased oxidant stress, decreased L-arginine and tetrahydrobiopterin." | 7.78 | Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat. ( Messina, LM; Tie, G; Yan, J, 2012) |
| "The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits." | 7.73 | Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. ( Khodosovskii, MN; Zinchuk, VV, 2006) |
| "Preischemia or prereperfusion administration of trapidil (8 mg/kg) was evaluated in the rat sciatic nerve I/R injury model." | 7.71 | Effect of trapidil in ischemia/reperfusion injury of peripheral nerves. ( Bagdatoglu, C; Ozturk, H; Saray, A; Surucu, HS; Tamer, L, 2002) |
| "Hyperhomocysteinemia (HH) is an independent risk factor for atherosclerosis, including peripheral arterial occlusive disease (PAOD)." | 7.70 | Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. ( Akita, T; Duan, J; Ikeda, H; Imaizumi, T; Murohara, T; Sasaki, K; Shimada, T; Shintani, S, 2000) |
| " We have found that the beneficial effects of dipyridamole therapy are due to its ability to increase tissue nitric oxide bioavailability that corrects tissue redox imbalance." | 6.46 | Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses. ( Fang, K; Kevil, CG; Pattillo, CB; Terracciano, J, 2010) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 5.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| " Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 5.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
| "To examine the antioxidant role of propofol in ischemia-reperfusion during carotid endarterectomy (CEA) and its influence on cognitive dysfunction after CEA." | 5.17 | Cognitive function and oxidative stress after carotid endarterectomy: comparison of propofol to sevoflurane anesthesia. ( Fragopoulou, E; Kakisis, J; Kalimeris, K; Kostopanagiotou, G; Kouni, S; Matsota, P; Nomikos, T; Pandazi, A; Vasdekis, S, 2013) |
| " Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance." | 3.85 | Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m). ( Fothergill, DM; Gasier, HG; Loiselle, AR; Reinhold, AR; Soutiere, SE, 2017) |
| " During limb ischemia, decreased NO bioavailability occurs secondary to increased oxidant stress, decreased L-arginine and tetrahydrobiopterin." | 3.78 | Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat. ( Messina, LM; Tie, G; Yan, J, 2012) |
| "Hydrogen sulfide (H(2)S) therapy is recognized as a modulator of vascular function during tissue ischemia with the notion of potential interactions of nitric oxide (NO) metabolism." | 3.78 | Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis. ( Bir, SC; Kevil, CG; Kolluru, GK; McCarthy, P; Pardue, S; Pattillo, CB; Shen, X, 2012) |
| "The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits." | 3.73 | Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. ( Khodosovskii, MN; Zinchuk, VV, 2006) |
| " ONO-1714 significantly attenuated apoptosis and necrosis, the expression of nitrotyrosine, and the increases of the plasma aspartate aminotransferase, lactate dehydrogenase, and NO(2)- + NO(3)- levels in the reperfusion phase." | 3.72 | Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714. ( Hirata, K; Isobe, M; Katsuramaki, T; Kimura, H; Kukita, K; Meguro, M; Nagayama, M; Nui, A, 2003) |
| "Preischemia or prereperfusion administration of trapidil (8 mg/kg) was evaluated in the rat sciatic nerve I/R injury model." | 3.71 | Effect of trapidil in ischemia/reperfusion injury of peripheral nerves. ( Bagdatoglu, C; Ozturk, H; Saray, A; Surucu, HS; Tamer, L, 2002) |
| " To determine the level of NO in the cochlea after 20 to 120 min of ischemia, nitrites/nitrates in the perilymph were measured." | 3.71 | Effects of nitric oxide on normal and ischemic cochlea of the guinea pig. ( Leong, SK; Ruan, RS; Yeoh, KH, 2001) |
| " We examined the hypothesis that HC may inhibit ischemia-induced angiogenesis by inhibition of EDNO in a rat model of unilateral hindlimb ischemia and that oral L-arginine supplementation, a substrate for NO synthase, may prevent HC-related impairment of angiogenesis." | 3.70 | Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism. ( Duan, J; Ikeda, H; Imaizumi, T; Katoh, A; Kawata, H; Murohara, T; Sasaki, K; Shintani, S; Yamamoto, N, 2000) |
| "Hyperhomocysteinemia (HH) is an independent risk factor for atherosclerosis, including peripheral arterial occlusive disease (PAOD)." | 3.70 | Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. ( Akita, T; Duan, J; Ikeda, H; Imaizumi, T; Murohara, T; Sasaki, K; Shimada, T; Shintani, S, 2000) |
| " Nitrates clearly express the injury to the organs caused by warm ischemia-reperfusion." | 3.69 | [Role of nitric oxide in warm ischemia of the transplanted kidney]. ( Antolín Juárez, F; Correas Gómez, MA; de Diego Rodríguez, JE; del Valle Schaan, JI; Gutiérrez Baños, JL; Gutiérrez García, R; Hernández Rodríguez, R; Martín García, B; Portillo Martín, JA; Roca Edreira, A; Vega Vega, A; Villanueva Peña, A, 1997) |
| " We have found that the beneficial effects of dipyridamole therapy are due to its ability to increase tissue nitric oxide bioavailability that corrects tissue redox imbalance." | 2.46 | Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses. ( Fang, K; Kevil, CG; Pattillo, CB; Terracciano, J, 2010) |
| " This rapid post-ischemic decrease in NO bioavailability appears to be due to decreased synthesis of NO, enhanced inactivation of NO by the overproduction of superoxide or both." | 2.45 | Hepatocellular protection by nitric oxide or nitrite in ischemia and reperfusion injury. ( Abe, Y; Grisham, MB; Hines, I; Zibari, G, 2009) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 1.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| " Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 1.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
| "Ischemia is a major factor contributing to failure of skin flap surgery, which is routinely used for coverage of wounds to prevent infection and to restore form and function." | 1.38 | Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps. ( Altavilla, D; Bitto, A; Calò, M; Galeano, M; Irrera, N; Marini, H; Polito, F; Squadrito, F, 2012) |
| "Dipyridamole treatment quickly restored ischaemic hindlimb blood flow, increased vascular density and cell proliferation, and enhanced collateral artery perfusion compared with control treatments." | 1.36 | Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathway. ( Branch, B; Hood, J; Illum, S; Kevil, CG; Pardue, S; Patel, RP; Pattillo, CB; Teng, X; Thoma, S; Venkatesh, PK, 2010) |
| "The delaying effects of remote reperfusion injury on the wound-healing process in colonic anastomoses have been previously shown." | 1.35 | Activated protein C prevents deleterious effects of remote reperfusion injury caused by intestinal ischemia on wound healing in the left colonic anastomoses: an experimental study in the murine model. ( Atalay, AO; Bicakci, T; Erdem, E; Sacar, M; Teke, Z; Yenisey, C, 2008) |
| "Lower-limb ischemia is a major health problem." | 1.33 | Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb. ( Botti, C; Byrns, RE; de Nigris, F; de Rosa, G; Farzati, B; Fiore, A; Ignarro, LJ; Lerman, LO; Matarazzo, A; Napoli, C; Sica, G; Sica, V; Sumi, D; Williams-Ignarro, S, 2005) |
| "The mechanism of gut injury in endotoxic shock seems unrelated to hypoxia and release of nitric oxide." | 1.32 | Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia. ( De Backer, D; Dimopoulos, G; Lobo, SM; Nagy, N; Preiser, JC; Sun, Q; Terzi, RG; Tu, Z; Vercruy, V; Vincent, JL; Vray, B, 2003) |
| "The rats with diabetic acute renal failure had a much lower creatinine clearance (90 +/- 22 microliters." | 1.29 | Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats. ( Blum, M; Cabili, S; Chernihovsky, T; Goor, Y; Iaina, A; Peer, G; Silverberg, D; Wollman, Y, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (13.04) | 18.2507 |
| 2000's | 39 (56.52) | 29.6817 |
| 2010's | 18 (26.09) | 24.3611 |
| 2020's | 3 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Nahavandi, S | 1 |
| Ahmadi, S | 1 |
| Sobhani, SA | 1 |
| Abbasi, T | 1 |
| Dehghani, A | 1 |
| Olejnik, A | 1 |
| Banaszkiewicz, M | 1 |
| Krzywonos-Zawadzka, A | 1 |
| Bil-Lula, I | 1 |
| Travis, OK | 1 |
| Baik, C | 1 |
| Tardo, GA | 1 |
| Amaral, L | 1 |
| Jackson, C | 1 |
| Greer, M | 1 |
| Giachelli, C | 1 |
| Ibrahim, T | 1 |
| Herrock, OT | 1 |
| Williams, JM | 1 |
| Cornelius, DC | 1 |
| Gasier, HG | 1 |
| Reinhold, AR | 1 |
| Loiselle, AR | 1 |
| Soutiere, SE | 1 |
| Fothergill, DM | 1 |
| de Medeiros, WA | 1 |
| da Silva, LA | 1 |
| Dall'Igna, DM | 1 |
| Michels, M | 1 |
| Manfredini, A | 1 |
| Dos Santos Cardoso, J | 1 |
| Constantino, L | 1 |
| Scaini, G | 1 |
| Vuolo, F | 1 |
| Streck, EL | 1 |
| Ritter, C | 1 |
| Dal-Pizzol, F | 1 |
| Sertorio, JT | 1 |
| Tanus-Santos, JE | 1 |
| Cui, H | 1 |
| Wang, Y | 2 |
| Feng, Y | 1 |
| Li, X | 1 |
| Bu, L | 1 |
| Pang, B | 1 |
| Jia, M | 1 |
| Iltar, S | 1 |
| Kılınç, CY | 1 |
| Alemdaroğlu, KB | 1 |
| Ozcan, S | 1 |
| Aydoğan, NH | 1 |
| Sürer, H | 1 |
| Kılınç, AŞ | 1 |
| Kalimeris, K | 1 |
| Kouni, S | 1 |
| Kostopanagiotou, G | 1 |
| Nomikos, T | 1 |
| Fragopoulou, E | 1 |
| Kakisis, J | 1 |
| Vasdekis, S | 1 |
| Matsota, P | 1 |
| Pandazi, A | 1 |
| Lo, HC | 1 |
| Yang, RB | 1 |
| Lee, CH | 1 |
| Ghosh, M | 1 |
| Subramani, J | 1 |
| Rahman, MM | 1 |
| Shapiro, LH | 1 |
| Liu, M | 1 |
| Zollbrecht, C | 1 |
| Peleli, M | 1 |
| Lundberg, JO | 2 |
| Weitzberg, E | 2 |
| Carlström, M | 1 |
| Polhemus, DJ | 1 |
| Bradley, JM | 1 |
| Islam, KN | 1 |
| Brewster, LP | 1 |
| Calvert, JW | 1 |
| Tao, YX | 1 |
| Chang, CC | 1 |
| Pipinos, II | 1 |
| Goodchild, TT | 1 |
| Lefer, DJ | 1 |
| Nair, A | 1 |
| Khan, S | 1 |
| Omar, S | 1 |
| Pei, XQ | 1 |
| McNeill, K | 1 |
| Chowienczyk, P | 1 |
| Webb, AJ | 1 |
| Mazzone, M | 1 |
| Carmeliet, P | 1 |
| Feelisch, M | 1 |
| Fernandez, BO | 1 |
| Bryan, NS | 1 |
| Garcia-Saura, MF | 1 |
| Bauer, S | 1 |
| Whitlock, DR | 1 |
| Ford, PC | 1 |
| Janero, DR | 1 |
| Rodriguez, J | 1 |
| Ashrafian, H | 1 |
| Abe, Y | 1 |
| Hines, I | 1 |
| Zibari, G | 1 |
| Grisham, MB | 1 |
| de Haro Miralles, J | 1 |
| Martínez-Aguilar, E | 1 |
| Florez, A | 1 |
| Varela, C | 1 |
| Bleda, S | 1 |
| Acin, F | 1 |
| Raat, NJ | 2 |
| Shiva, S | 3 |
| Gladwin, MT | 2 |
| Noguchi, AC | 1 |
| Liu, VB | 1 |
| Raghavachari, N | 1 |
| Liu, D | 1 |
| Xu, X | 1 |
| Munson, PJ | 1 |
| Isenberg, JS | 1 |
| Gladwin, M | 1 |
| Portugal-Cohen, M | 1 |
| Kohen, R | 1 |
| Nematollahi, S | 1 |
| Nematbakhsh, M | 1 |
| Haghjooyjavanmard, S | 1 |
| Khazaei, M | 1 |
| Salehi, M | 1 |
| Venkatesh, PK | 1 |
| Pattillo, CB | 3 |
| Branch, B | 1 |
| Hood, J | 1 |
| Thoma, S | 1 |
| Illum, S | 1 |
| Pardue, S | 2 |
| Teng, X | 1 |
| Patel, RP | 1 |
| Kevil, CG | 3 |
| Fang, K | 1 |
| Terracciano, J | 1 |
| Wang, WZ | 1 |
| Fang, XH | 1 |
| Stephenson, LL | 1 |
| Zhang, X | 1 |
| Williams, SJ | 1 |
| Baynosa, RC | 1 |
| Khiabani, KT | 1 |
| Zamboni, WA | 1 |
| Polito, F | 1 |
| Bitto, A | 1 |
| Galeano, M | 1 |
| Irrera, N | 1 |
| Marini, H | 1 |
| Calò, M | 1 |
| Squadrito, F | 1 |
| Altavilla, D | 1 |
| Hendgen-Cotta, UB | 1 |
| Luedike, P | 1 |
| Totzeck, M | 1 |
| Kropp, M | 1 |
| Schicho, A | 1 |
| Stock, P | 1 |
| Rammos, C | 1 |
| Niessen, M | 1 |
| Heiss, C | 1 |
| Kelm, M | 1 |
| Rassaf, T | 1 |
| Yan, J | 1 |
| Tie, G | 1 |
| Messina, LM | 1 |
| Bir, SC | 1 |
| Kolluru, GK | 1 |
| McCarthy, P | 1 |
| Shen, X | 1 |
| Bagdatoglu, C | 1 |
| Saray, A | 1 |
| Surucu, HS | 1 |
| Ozturk, H | 1 |
| Tamer, L | 1 |
| Meguro, M | 2 |
| Katsuramaki, T | 2 |
| Kimura, H | 2 |
| Isobe, M | 2 |
| Nagayama, M | 2 |
| Kukita, K | 1 |
| Nui, A | 2 |
| Hirata, K | 2 |
| Lobo, SM | 1 |
| De Backer, D | 1 |
| Sun, Q | 1 |
| Tu, Z | 2 |
| Dimopoulos, G | 1 |
| Preiser, JC | 1 |
| Nagy, N | 1 |
| Vray, B | 1 |
| Vercruy, V | 1 |
| Terzi, RG | 1 |
| Vincent, JL | 1 |
| Ng, ES | 1 |
| Jourd'heuil, D | 1 |
| McCord, JM | 1 |
| Hernandez, D | 1 |
| Yasui, M | 1 |
| Knight, D | 1 |
| Kubes, P | 1 |
| Shimada, T | 2 |
| Takeshita, Y | 1 |
| Murohara, T | 3 |
| Sasaki, K | 3 |
| Egami, K | 1 |
| Shintani, S | 3 |
| Katsuda, Y | 1 |
| Ikeda, H | 3 |
| Nabeshima, Y | 1 |
| Imaizumi, T | 3 |
| Jacobi, J | 1 |
| Sydow, K | 1 |
| von Degenfeld, G | 1 |
| Zhang, Y | 1 |
| Dayoub, H | 1 |
| Wang, B | 1 |
| Patterson, AJ | 1 |
| Kimoto, M | 1 |
| Blau, HM | 1 |
| Cooke, JP | 1 |
| Meadows, GE | 1 |
| Kotajima, F | 1 |
| Vazir, A | 1 |
| Kostikas, K | 1 |
| Simonds, AK | 1 |
| Morrell, MJ | 1 |
| Corfield, DR | 1 |
| Napoli, C | 1 |
| Williams-Ignarro, S | 1 |
| de Nigris, F | 1 |
| de Rosa, G | 1 |
| Lerman, LO | 1 |
| Farzati, B | 1 |
| Matarazzo, A | 1 |
| Sica, G | 1 |
| Botti, C | 1 |
| Fiore, A | 1 |
| Byrns, RE | 1 |
| Sumi, D | 1 |
| Sica, V | 1 |
| Ignarro, LJ | 1 |
| Viñas, JL | 1 |
| Sola, A | 1 |
| Hotter, G | 1 |
| Akasaki, Y | 1 |
| Miyata, M | 1 |
| Eto, H | 1 |
| Shirasawa, T | 1 |
| Hamada, N | 1 |
| Ikeda, Y | 1 |
| Biro, S | 1 |
| Otsuji, Y | 1 |
| Tei, C | 1 |
| Shantarina, EV | 1 |
| Levitina, EV | 1 |
| Zhuravleva, TD | 1 |
| Unno, N | 1 |
| Uchiyama, T | 1 |
| Yamamoto, N | 2 |
| Inuzuka, K | 1 |
| Sagara, D | 1 |
| Konno, H | 1 |
| Stefanutti, G | 1 |
| Pierro, A | 1 |
| Smith, VV | 1 |
| Klein, NJ | 1 |
| Eaton, S | 1 |
| Kim, HW | 1 |
| Lin, A | 1 |
| Guldberg, RE | 1 |
| Ushio-Fukai, M | 1 |
| Fukai, T | 1 |
| Khodosovskii, MN | 1 |
| Zinchuk, VV | 1 |
| Joviliano, EE | 1 |
| Piccinato, CE | 1 |
| Cherri, J | 1 |
| Viaro, F | 1 |
| Moryia, T | 1 |
| Celotto, AC | 1 |
| Bonaventura, D | 1 |
| Evora, PR | 1 |
| Lauer, S | 1 |
| Daudel, F | 1 |
| Traber, DL | 1 |
| Nofer, JR | 1 |
| Ertmer, C | 1 |
| Morelli, A | 1 |
| Van Aken, H | 1 |
| Lange, M | 1 |
| Rehberg, S | 1 |
| Ellger, B | 1 |
| Stubbe, HD | 1 |
| Kruse, C | 1 |
| Bone, HG | 1 |
| Westphal, M | 1 |
| Teke, Z | 1 |
| Sacar, M | 1 |
| Yenisey, C | 1 |
| Atalay, AO | 1 |
| Bicakci, T | 1 |
| Erdem, E | 1 |
| Ischiropoulos, H | 1 |
| al-Mehdi, AB | 1 |
| Fisher, AB | 1 |
| Esteban, F | 1 |
| Gómez-Jiménez, J | 1 |
| Martín, MC | 1 |
| Ruíz, JC | 1 |
| Nuvials, X | 1 |
| García-Allut, JL | 1 |
| Sauri, R | 1 |
| Murio, JE | 1 |
| Mourelle, M | 1 |
| Segura, RM | 1 |
| Bustamante, SA | 1 |
| Sanches, N | 1 |
| Crosier, J | 1 |
| Miranda, D | 1 |
| Colombo, G | 1 |
| Miller, MJ | 1 |
| Goor, Y | 1 |
| Peer, G | 1 |
| Iaina, A | 1 |
| Blum, M | 1 |
| Wollman, Y | 1 |
| Chernihovsky, T | 1 |
| Silverberg, D | 1 |
| Cabili, S | 1 |
| Caramelo, C | 1 |
| Espinosa, G | 1 |
| Manzarbeitia, F | 1 |
| Cernadas, MR | 1 |
| Pérez Tejerizo, G | 1 |
| Tan, D | 1 |
| Mosquera, JR | 1 |
| Digiuni, E | 1 |
| Montón, M | 1 |
| Millás, I | 1 |
| Hernando, L | 1 |
| Casado, S | 1 |
| López-Farré, A | 1 |
| Correas Gómez, MA | 1 |
| Martín García, B | 1 |
| Antolín Juárez, F | 1 |
| Hernández Rodríguez, R | 1 |
| Portillo Martín, JA | 1 |
| Gutiérrez Baños, JL | 1 |
| del Valle Schaan, JI | 1 |
| Roca Edreira, A | 1 |
| Vega Vega, A | 1 |
| Villanueva Peña, A | 1 |
| Gutiérrez García, R | 1 |
| de Diego Rodríguez, JE | 1 |
| Lawson, JA | 1 |
| Jaeschke, H | 1 |
| Liu, P | 2 |
| Xu, B | 2 |
| Hock, CE | 1 |
| Nagele, R | 1 |
| Sun, FF | 1 |
| Wong, PY | 2 |
| Mazzone, A | 1 |
| Cusa, C | 1 |
| Bucci, L | 1 |
| Vezzoli, M | 1 |
| Ghio, S | 1 |
| Buggia, I | 1 |
| Regazzi, MB | 1 |
| Fossati, G | 1 |
| Mazzucchelli, I | 1 |
| Gritti, D | 1 |
| Spokas, E | 1 |
| Lai, PS | 1 |
| Prior, DL | 1 |
| Chin-Dusting, JP | 1 |
| Duan, J | 2 |
| Katoh, A | 1 |
| Kawata, H | 1 |
| Akita, T | 1 |
| Osanai, H | 1 |
| Okumura, K | 1 |
| Hayakawa, M | 1 |
| Harada, M | 1 |
| Numaguchi, Y | 1 |
| Mokuno, S | 1 |
| Murase, K | 1 |
| Matsui, H | 1 |
| Toki, Y | 1 |
| Ito, T | 1 |
| Hayakawa, T | 1 |
| Capaldo, B | 1 |
| Guardasole, V | 1 |
| Pardo, F | 1 |
| Matarazzo, M | 1 |
| Di Rella , F | 1 |
| Numis, F | 1 |
| Merola, B | 1 |
| Longobardi, S | 1 |
| Saccà, L | 1 |
| Valdivielso, JM | 1 |
| Crespo, C | 1 |
| Alonso, JR | 1 |
| Martínez-Salgado, C | 1 |
| Eleno, N | 1 |
| Arévalo, M | 1 |
| Pérez-Barriocanal, F | 1 |
| López-Novoa, JM | 1 |
| Ruan, RS | 1 |
| Leong, SK | 1 |
| Yeoh, KH | 1 |
| Noiri, E | 1 |
| Nakao, A | 1 |
| Uchida, K | 1 |
| Tsukahara, H | 1 |
| Ohno, M | 1 |
| Fujita, T | 1 |
| Brodsky, S | 1 |
| Goligorsky, MS | 1 |
| Ogawa, T | 1 |
| Nussler, AK | 1 |
| Tuzuner, E | 1 |
| Mimura, Y | 1 |
| Kaminishi, M | 1 |
| Beger, HG | 1 |
| Tokuyama, H | 1 |
| Hayashi, K | 1 |
| Matsuda, H | 1 |
| Kubota, E | 1 |
| Honda, M | 1 |
| Okubo, K | 1 |
| Ozawa, Y | 1 |
| Saruta, T | 1 |
| Kimura, Y | 1 |
| Matsuno, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy[NCT03115034] | Phase 4 | 60 participants (Actual) | Interventional | 2016-06-01 | Completed | ||
| Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on Incidence of Postoperative Delirium in Elderly Patients After Cancer Surgery: An Open-label, Randomized Controlled Trial[NCT02662257] | 1,228 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Safety and Effects of PDRN(Polydeoxyribonucleotide) Injection in Patient With Elbow Epicondylitis in Randomized Double-blind Active-control Comparative Study[NCT02492945] | Phase 4 | 40 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nitrites and Ischemia
| Article | Year |
|---|---|
Hepatocellular protection by nitric oxide or nitrite in ischemia and reperfusion injury.
Topics: Animals; Cytokines; Hepatocytes; Humans; Ischemia; Liver Circulation; Liver Transplantation; Nitric | 2009 |
Effects of nitrite on modulating ROS generation following ischemia and reperfusion.
Topics: Animals; Humans; Ischemia; Nitric Oxide Donors; Nitrites; Reactive Oxygen Species; Reperfusion Injur | 2009 |
Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.
Topics: Animals; Dipyridamole; Down-Regulation; Humans; Immunity, Innate; Inflammation; Ischemia; Neovascula | 2010 |
5 trials available for nitrites and Ischemia
| Article | Year |
|---|---|
Cognitive function and oxidative stress after carotid endarterectomy: comparison of propofol to sevoflurane anesthesia.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2013 |
Cognitive function and oxidative stress after carotid endarterectomy: comparison of propofol to sevoflurane anesthesia.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2013 |
Cognitive function and oxidative stress after carotid endarterectomy: comparison of propofol to sevoflurane anesthesia.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2013 |
Cognitive function and oxidative stress after carotid endarterectomy: comparison of propofol to sevoflurane anesthesia.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2013 |
Remote ischaemic preconditioning suppresses endogenous plasma nitrite during ischaemia-reperfusion: a randomized controlled crossover pilot study.
Topics: Adult; Cross-Over Studies; Healthy Volunteers; Humans; Ischemia; Ischemic Preconditioning; Male; Nit | 2017 |
The effects of iloprost infusion on microcirculation is independent of nitric oxide metabolites and endothelin-1 in chronic peripheral ischaemia.
Topics: Adult; Aged; Arterial Occlusive Diseases; Chronic Disease; Endothelin-1; Endothelium, Vascular; Fema | 1999 |
Transient improvement of acetylcholine responses after short-term oral L-arginine in forearms of human heart failure.
Topics: Acetylcholine; Administration, Oral; Adult; Analysis of Variance; Arginine; Blood Pressure; Cross-Ov | 2000 |
Abnormal vascular reactivity in growth hormone deficiency.
Topics: Acetylcholine; Adult; Blood Flow Velocity; Blood Pressure; Blood Vessels; Cyclic GMP; Dose-Response | 2001 |
61 other studies available for nitrites and Ischemia
| Article | Year |
|---|---|
A high dose of estrogen can improve renal ischemia-reperfusion-induced pulmonary injury in ovariectomized female rats.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Estradiol; Female; Injections, Intramuscular | 2021 |
The Klotho protein supports redox balance and metabolic functions of cardiomyocytes during ischemia/reperfusion injury.
Topics: Deoxyglucose; Glucose; Humans; Hydrogen Peroxide; Ischemia; Lactates; Myocytes, Cardiac; NADP; NADPH | 2022 |
Adoptive transfer of placental ischemia-stimulated natural killer cells causes a preeclampsia-like phenotype in pregnant rats.
Topics: Adoptive Transfer; Animals; Cyclic GMP; Cytokines; Female; Fetal Growth Retardation; Ischemia; Kille | 2021 |
Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m).
Topics: Adult; Athletic Performance; Blood Pressure; Exercise; Female; Forearm; Heart Rate; Humans; Hypoxia; | 2017 |
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alph | 2018 |
Mechanisms involved in proton pump inhibitors-induced increases in ischemic events.
Topics: Humans; Ischemia; Nitrates; Nitrites; Proton Pump Inhibitors | 2019 |
Dietary nitrate protects skin flap against ischemia injury in rats via enhancing blood perfusion.
Topics: Animals; Cytokines; Dermatologic Surgical Procedures; Diet; Inflammation Mediators; Ischemia; Male; | 2019 |
Does the method of expression of venous blood affect ischaemia/reperfusion damage in tourniquet use? An experimental study on rabbits.
Topics: Acidosis; Animals; Biomarkers; Ischemia; Malondialdehyde; Muscle, Skeletal; Nitrates; Nitrites; Orth | 2013 |
Guanylyl cyclase-G modulates jejunal apoptosis and inflammation in mice with intestinal ischemia and reperfusion.
Topics: Animals; Apoptosis; I-kappa B Proteins; Inflammation; Interleukin-6; Ischemia; Jejunum; JNK Mitogen- | 2014 |
CD13 restricts TLR4 endocytic signal transduction in inflammation.
Topics: Animals; CD13 Antigens; Cell Membrane; Dendritic Cells; Endocytosis; Endosomes; Gene Expression; Inf | 2015 |
Nitrite-mediated renal vasodilatation is increased during ischemic conditions via cGMP-independent signaling.
Topics: Animals; Cell Hypoxia; Cyclic GMP; Ischemia; Kidney; Male; Mice, Inbred C57BL; Nitrites; Second Mess | 2015 |
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.
Topics: Angiogenesis Inducing Agents; Animals; Delayed-Action Preparations; Disease Models, Animal; Hindlimb | 2015 |
Drug discovery: a lifeline for suffocating tissues.
Topics: Animals; Blood Vessels; Ischemia; Mice; Neovascularization, Physiologic; Nitric Oxide; Nitrites | 2008 |
Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems.
Topics: Animals; Heme; Hypoxia; Iron-Sulfur Proteins; Ischemia; Liver; Male; Mitochondria; Models, Theoretic | 2008 |
Nitric oxide: link between endothelial dysfunction and inflammation in patients with peripheral arterial disease of the lower limbs.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brachial Artery; C-Reactive Protein; Case-Control Studie | 2009 |
Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response.
Topics: Animal Structures; Animals; Cytoprotection; Diet; Gastric Mucosa; Gene Expression Profiling; Heart; | 2009 |
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Topics: Analysis of Variance; Animals; Back; CD47 Antigen; Cyclic GMP; Enzyme Inhibitors; Gene Silencing; Is | 2009 |
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase.
Topics: Biomarkers; Cell Hypoxia; Cell Line; Cell Survival; Glucose; Glutathione; Glutathione Disulfide; Hum | 2009 |
Inducible nitric oxide synthase modulates angiogenesis in ischemic hindlimb of rat.
Topics: Animals; Capillaries; Hindlimb; Ischemia; Male; Muscle, Skeletal; Neovascularization, Physiologic; N | 2009 |
Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathway.
Topics: Animals; Cell Division; Chronic Disease; Cyclic AMP-Dependent Protein Kinases; Dipyridamole; Dose-Re | 2010 |
Nitrite attenuates ischemia-reperfusion-induced microcirculatory alterations and mitochondrial dysfunction in the microvasculature of skeletal muscle.
Topics: Analysis of Variance; Animals; Cytochromes c; Disease Models, Animal; Dose-Response Relationship, Dr | 2011 |
Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps.
Topics: Adenosine A2 Receptor Agonists; Animals; Blood Flow Velocity; Dermatologic Surgical Procedures; Dise | 2012 |
Dietary nitrate supplementation improves revascularization in chronic ischemia.
Topics: Animal Feed; Animals; Bone Marrow Transplantation; Cell Movement; Chronic Disease; Cyclic GMP; Dieta | 2012 |
Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat.
Topics: Administration, Oral; Animals; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Hindlim | 2012 |
Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Hydrogen Sulfide; Hypoxia-Inducible Factor 1, alpha Subu | 2012 |
Effect of trapidil in ischemia/reperfusion injury of peripheral nerves.
Topics: Animals; Ischemia; Male; Malondialdehyde; Microscopy, Electron; Myelin Sheath; Nitrates; Nitrites; P | 2002 |
Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714.
Topics: Amidines; Animals; Apoptosis; Aspartate Aminotransferases; DNA; Enzyme Inhibitors; Female; Hepatocyt | 2003 |
Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia.
Topics: Animals; Blood Pressure; Carbon Dioxide; Ileum; Intestinal Mucosa; Ischemia; Lactic Acid; Lipopolysa | 2003 |
Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion.
Topics: Administration, Inhalation; Animals; Biological Transport; Cats; Constriction; Intestines; Ischemia; | 2004 |
Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse.
Topics: Aging, Premature; Animals; Aorta, Thoracic; Bone Marrow Transplantation; Collateral Circulation; Cyc | 2004 |
Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.
Topics: Amidohydrolases; Animals; Arginine; Enzyme Induction; Female; Hindlimb; Humans; Ischemia; Laser-Dopp | 2005 |
Overnight changes in the cerebral vascular response to isocapnic hypoxia and hypercapnia in healthy humans: protection against stroke.
Topics: Adult; Brain; Cerebrovascular Circulation; Humans; Hypercapnia; Hypoxia; Ischemia; Male; Middle Cere | 2005 |
Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb.
Topics: Animals; Antioxidants; Arginine; Bone Marrow Transplantation; Disease Models, Animal; Fluorescent An | 2005 |
Mitochondrial NOS upregulation during renal I/R causes apoptosis in a peroxynitrite-dependent manner.
Topics: Animals; Apoptosis; Biomarkers; Blotting, Western; Cytochromes c; Densitometry; Enzyme Inhibitors; I | 2006 |
Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia.
Topics: Animals; Apolipoproteins E; Blood Pressure; Blotting, Western; Body Weight; Female; Heart Rate; Hind | 2006 |
[The significance of determination of the serum levels of nitrites for assessing severity of perinatal ischemia and predicting the nervous and mental development of a child].
Topics: Biomarkers; Brain; Brain Diseases; Child Development; Fetal Hypoxia; Humans; Hypoxia, Brain; Infant; | 2006 |
Portal triad occlusion induces endotoxin tolerance: role of portal congestion.
Topics: Animals; Constriction; Cytokines; Endotoxemia; Endotoxins; Hemostasis, Surgical; Interleukin-6; Isch | 2006 |
Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats.
Topics: Animals; Animals, Suckling; Endothelial Cells; Glutathione; Intercellular Adhesion Molecule-1; Intes | 2007 |
Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemia.
Topics: Animals; Antioxidants; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiati | 2007 |
Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Aspartate Aminotransferases; Ischemia | 2006 |
In vitro pharmacological study of femoral artery vascular reactivity after inferior canine hindlimb ischemia/reperfusion: effects of in vivo nitric oxide blocker infusion.
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Endothelium-Dependent Relaxing Factors; Endothelium, Vascu | 2007 |
Somatostatin infusion increases intestinal ischemia and does not improve vasoconstrictor response to norepinephrine in ovine endotoxemia.
Topics: Animals; Endotoxemia; Female; Hemodynamics; Hypotension; Ischemia; Nitrates; Nitrites; Norepinephrin | 2008 |
Activated protein C prevents deleterious effects of remote reperfusion injury caused by intestinal ischemia on wound healing in the left colonic anastomoses: an experimental study in the murine model.
Topics: Analysis of Variance; Anastomosis, Surgical; Animals; Chi-Square Distribution; Glutathione; Glutathi | 2008 |
Reactive species in ischemic rat lung injury: contribution of peroxynitrite.
Topics: Animals; Arginine; Immunohistochemistry; Ischemia; Lung; Male; NG-Nitroarginine Methyl Ester; Nitrat | 1995 |
Nitric oxide and hepatic ischemic injury in human orthotopic liver transplantation.
Topics: Cardiac Output; Endotoxins; Female; Humans; Ischemia; Lipopolysaccharides; Liver; Liver Transplantat | 1995 |
Dietary nucleotides: effects on the gastrointestinal system in swine.
Topics: Adenosine; Animals; Animals, Newborn; Animals, Suckling; Diet; Digestive System; DNA; Granulocytes; | 1994 |
Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Arginine; Creatinine; Diabetes Mellitus, Experim | 1996 |
Role of endothelium-related mechanisms in the pathophysiology of renal ischemia/reperfusion in normal rabbits.
Topics: Animals; Arginine; Endothelium, Vascular; Hemodynamics; Ischemia; Kidney; Male; Neutrophils; Nitric | 1996 |
[Role of nitric oxide in warm ischemia of the transplanted kidney].
Topics: Animals; Biomarkers; Creatinine; Dogs; Graft Survival; Ischemia; Kidney; Kidney Transplantation; Nep | 1997 |
Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia.
Topics: Alanine Transaminase; Animals; beta-Aminoethyl Isothiourea; Blood Circulation; Blood Pressure; Endot | 1998 |
NO modulates P-selectin and ICAM-1 mRNA expression and hemodynamic alterations in hepatic I/R.
Topics: Alanine Transaminase; Animals; Cell Adhesion Molecules; Hemodynamics; Intercellular Adhesion Molecul | 1998 |
Role of endogenous nitric oxide in TNF-alpha and IL-1beta generation in hepatic ischemia-repefusion.
Topics: Alanine Transaminase; Animals; Down-Regulation; Enzyme Inhibitors; Interleukin-1; Ischemia; Leukocyt | 2000 |
Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism.
Topics: Administration, Oral; Animals; Arginine; Body Weight; Cholesterol, Dietary; Collateral Circulation; | 2000 |
Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia.
Topics: Angiography; Animals; Arginine; Blood Pressure; Body Weight; Collateral Circulation; Cyclic GMP; Dis | 2000 |
Ascorbic acid improves postischemic vasodilatation impaired by infusion of soybean oil into canine iliac artery.
Topics: Animals; Ascorbic Acid; Cholesterol; Coronary Circulation; Dogs; Enzyme Inhibitors; Fat Emulsions, I | 2000 |
Renal ischemia in the rat stimulates glomerular nitric oxide synthesis.
Topics: Animals; Blotting, Western; Constriction; Creatinine; Cyclic GMP; Enzyme Inhibitors; Female; Immunoh | 2001 |
Effects of nitric oxide on normal and ischemic cochlea of the guinea pig.
Topics: Animals; Catalase; Cell Count; Cochlea; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2001 |
Oxidative and nitrosative stress in acute renal ischemia.
Topics: Animals; Azoles; Blotting, Western; Cell Line; Cyclic N-Oxides; DNA Damage; Enzyme Inhibitors; Free | 2001 |
Inhibition of nitric oxide synthase does not influence urinary nitrite plus nitrate excretion after renal ischemic injury.
Topics: Animals; Disease Models, Animal; Ischemia; Kidney; Kidney Tubules; Male; NG-Nitroarginine Methyl Est | 2002 |
Stenosis-dependent role of nitric oxide and prostaglandins in chronic renal ischemia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Chronic Disease; Dinoprostone | 2002 |
A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver.
Topics: Amidines; Animals; Aspartate Aminotransferases; Enzyme Inhibitors; Female; Heterocyclic Compounds, 2 | 2002 |