ssr180575 and Ischemia

ssr180575 has been researched along with Ischemia* in 1 studies

Other Studies

1 other study(ies) available for ssr180575 and Ischemia

Article	Year
Binding characteristics of SSR180575, a potent and selective peripheral benzodiazepine ligand. Biochemical and biophysical research communications, 2003, Oct-24, Volume: 310, Issue:3 The peripheral benzodiazepine receptor (PBR), has been recently shown to play a key role in the regulation of the mitochondrial process leading to apoptosis, which occurs during cardiac ischemia. The present work shows that SSR180575, a novel PBR ligand of potential interest in pathological cardiovascular indications, irreversibly and specifically binds with high affinity on both rat heart mitochondria and on a cell line transfected with the human PBR (K(d)=1.95+/-0.22 and 4.58+/-0.83nM, respectively). In conclusion, SSR180575 is a specific and potent PBR ligand which irreversible binding to PBR appears of high interest in various therapeutic indications where apoptosis occurs. Topics: Acetamides; Animals; Benzodiazepines; Blotting, Western; Cell Line; Humans; Indoles; Inhibitory Concentration 50; Ischemia; Kinetics; Ligands; Male; Mitochondria; Myocardium; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors; Transfection	2003

Article

Year

Binding characteristics of SSR180575, a potent and selective peripheral benzodiazepine ligand.

Biochemical and biophysical research communications, 2003, Oct-24, Volume: 310, Issue:3

The peripheral benzodiazepine receptor (PBR), has been recently shown to play a key role in the regulation of the mitochondrial process leading to apoptosis, which occurs during cardiac ischemia. The present work shows that SSR180575, a novel PBR ligand of potential interest in pathological cardiovascular indications, irreversibly and specifically binds with high affinity on both rat heart mitochondria and on a cell line transfected with the human PBR (K(d)=1.95+/-0.22 and 4.58+/-0.83nM, respectively). In conclusion, SSR180575 is a specific and potent PBR ligand which irreversible binding to PBR appears of high interest in various therapeutic indications where apoptosis occurs.

Topics: Acetamides; Animals; Benzodiazepines; Blotting, Western; Cell Line; Humans; Indoles; Inhibitory Concentration 50; Ischemia; Kinetics; Ligands; Male; Mitochondria; Myocardium; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors; Transfection

2003