2-amino-5-phosphonovalerate has been researched along with Ischemia in 13 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effect of 3-nitropropionic acid (3-NPA) and ischemia (glucose- and O(2)-free solution) on synaptic transmission in hemisected spinal cord from 4 to 8 day old rats was examined in vitro." | 7.74 | 3-Nitropropionic acid-induced depression of spinal reflexes involves mechanisms different from ischemia-induced depression. ( Deshpande, SB; Gupta, R, 2008) |
| "Effect of 3-nitropropionic acid (3-NPA) and ischemia (glucose- and O(2)-free solution) on synaptic transmission in hemisected spinal cord from 4 to 8 day old rats was examined in vitro." | 3.74 | 3-Nitropropionic acid-induced depression of spinal reflexes involves mechanisms different from ischemia-induced depression. ( Deshpande, SB; Gupta, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carpanese, E | 1 |
| Moretto, P | 1 |
| Filpa, V | 1 |
| Marchet, S | 1 |
| Moro, E | 1 |
| Crema, F | 1 |
| Frigo, G | 1 |
| Giaroni, C | 1 |
| Gupta, R | 1 |
| Deshpande, SB | 1 |
| Robert, F | 1 |
| Bert, L | 1 |
| Stoppini, L | 1 |
| Petzold, GC | 1 |
| Windmüller, O | 1 |
| Haack, S | 1 |
| Major, S | 1 |
| Buchheim, K | 1 |
| Megow, D | 1 |
| Gabriel, S | 1 |
| Lehmann, TN | 1 |
| Drenckhahn, C | 1 |
| Peters, O | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 1 |
| Dirnagl, U | 1 |
| Dreier, JP | 1 |
| Wirkner, K | 1 |
| Köfalvi, A | 1 |
| Fischer, W | 1 |
| Günther, A | 1 |
| Franke, H | 1 |
| Gröger-Arndt, H | 1 |
| Nörenberg, W | 1 |
| Madarász, E | 1 |
| Vizi, ES | 1 |
| Schneider, D | 1 |
| Sperlágh, B | 1 |
| Illes, P | 1 |
| Li, Z | 1 |
| Zhou, R | 1 |
| Cui, S | 1 |
| Xie, G | 1 |
| Cai, W | 1 |
| Sokabe, M | 1 |
| Chen, L | 1 |
| Lombardi, G | 1 |
| Moroni, F | 2 |
| Gee, BY | 1 |
| Tjen-A-Looi, SC | 1 |
| Hill, JM | 1 |
| Chahal, PS | 1 |
| Longhurst, JC | 1 |
| Sher, GD | 2 |
| Cartmell, SM | 1 |
| Gelgor, L | 1 |
| Mitchell, D | 2 |
| Pujol, R | 1 |
| Puel, JL | 1 |
| Eybalin, M | 1 |
| Chen, S | 1 |
| Mohajerani, MH | 1 |
| Xie, Y | 1 |
| Murphy, TH | 1 |
| Cronberg, T | 1 |
| Jensen, K | 1 |
| Rytter, A | 1 |
| Wieloch, T | 1 |
13 other studies available for 2-amino-5-phosphonovalerate and Ischemia
| Article | Year |
|---|---|
Antagonism of ionotropic glutamate receptors attenuates chemical ischemia-induced injury in rat primary cultured myenteric ganglia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Count; Cell Surviva | 2014 |
3-Nitropropionic acid-induced depression of spinal reflexes involves mechanisms different from ischemia-induced depression.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Con | 2008 |
Blockade of NMDA-receptors or calcium-channels attenuates the ischaemia-evoked efflux of glutamate and phosphoethanolamine and depression of neuronal activity in rat organotypic hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channel Blockers; Cell Hypoxia; Deoxyglucose; Diltiaze | 2002 |
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Body Temperature; Brain; Brain Injuries; Cortical Spreading De | 2005 |
Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Anestheti | 2005 |
Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anisoles; Behavior, Animal; Blotting, Western; Dehydroepiandro | 2006 |
Glutamate receptor antagonists protect against ischemia-induced retinal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Ischemia; Rats; Receptors, | 1994 |
Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia.
Topics: 2-Amino-5-phosphonovalerate; Abdomen; Animals; Baroreflex; Cats; Decerebrate State; Excitatory Amino | 2002 |
Role of N-methyl-D-aspartate and opiate receptors in nociception during and after ischaemia in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hot Temperature; Hyperalgesia; Ischemia; Male; Meperidine; Mor | 1992 |
Implication of non-NMDA and NMDA receptors in cochlear ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cochlea; Dendrites; Guinea Pigs; Hair Cells, Auditory; Ischemi | 1992 |
Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex.
Topics: Anesthetics, Local; Animals; Bacterial Proteins; Carrier Proteins; Channelrhodopsins; Disease Models | 2012 |
Selective sparing of hippocampal CA3 cells following in vitro ischemia is due to selective inhibition by acidosis.
Topics: Acidosis; Animals; Animals, Newborn; Calcium; Cell Death; Excitatory Amino Acid Antagonists; Excitat | 2005 |
N-methyl-D-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia.
Topics: Animals; Anterior Horn Cells; Hindlimb; Injections, Spinal; Ischemia; Ketamine; Male; Pain; Physical | 1990 |