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2-amino-5-phosphonovalerate and Ischemia

2-amino-5-phosphonovalerate has been researched along with Ischemia in 13 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"Effect of 3-nitropropionic acid (3-NPA) and ischemia (glucose- and O(2)-free solution) on synaptic transmission in hemisected spinal cord from 4 to 8 day old rats was examined in vitro."7.743-Nitropropionic acid-induced depression of spinal reflexes involves mechanisms different from ischemia-induced depression. ( Deshpande, SB; Gupta, R, 2008)
"Effect of 3-nitropropionic acid (3-NPA) and ischemia (glucose- and O(2)-free solution) on synaptic transmission in hemisected spinal cord from 4 to 8 day old rats was examined in vitro."3.743-Nitropropionic acid-induced depression of spinal reflexes involves mechanisms different from ischemia-induced depression. ( Deshpande, SB; Gupta, R, 2008)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (30.77)18.2507
2000's7 (53.85)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carpanese, E1
Moretto, P1
Filpa, V1
Marchet, S1
Moro, E1
Crema, F1
Frigo, G1
Giaroni, C1
Gupta, R1
Deshpande, SB1
Robert, F1
Bert, L1
Stoppini, L1
Petzold, GC1
Windmüller, O1
Haack, S1
Major, S1
Buchheim, K1
Megow, D1
Gabriel, S1
Lehmann, TN1
Drenckhahn, C1
Peters, O1
Meierkord, H1
Heinemann, U1
Dirnagl, U1
Dreier, JP1
Wirkner, K1
Köfalvi, A1
Fischer, W1
Günther, A1
Franke, H1
Gröger-Arndt, H1
Nörenberg, W1
Madarász, E1
Vizi, ES1
Schneider, D1
Sperlágh, B1
Illes, P1
Li, Z1
Zhou, R1
Cui, S1
Xie, G1
Cai, W1
Sokabe, M1
Chen, L1
Lombardi, G1
Moroni, F2
Gee, BY1
Tjen-A-Looi, SC1
Hill, JM1
Chahal, PS1
Longhurst, JC1
Sher, GD2
Cartmell, SM1
Gelgor, L1
Mitchell, D2
Pujol, R1
Puel, JL1
Eybalin, M1
Chen, S1
Mohajerani, MH1
Xie, Y1
Murphy, TH1
Cronberg, T1
Jensen, K1
Rytter, A1
Wieloch, T1

Other Studies

13 other studies available for 2-amino-5-phosphonovalerate and Ischemia

ArticleYear
Antagonism of ionotropic glutamate receptors attenuates chemical ischemia-induced injury in rat primary cultured myenteric ganglia.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Count; Cell Surviva

2014
3-Nitropropionic acid-induced depression of spinal reflexes involves mechanisms different from ischemia-induced depression.
    Brain research bulletin, 2008, Dec-16, Volume: 77, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Con

2008
Blockade of NMDA-receptors or calcium-channels attenuates the ischaemia-evoked efflux of glutamate and phosphoethanolamine and depression of neuronal activity in rat organotypic hippocampal slice cultures.
    Comptes rendus biologies, 2002, Volume: 325, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channel Blockers; Cell Hypoxia; Deoxyglucose; Diltiaze

2002
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.
    Stroke, 2005, Volume: 36, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Body Temperature; Brain; Brain Injuries; Cortical Spreading De

2005
Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
    Journal of neurochemistry, 2005, Volume: 95, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Anestheti

2005
Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor.
    Neuropharmacology, 2006, Volume: 51, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anisoles; Behavior, Animal; Blotting, Western; Dehydroepiandro

2006
Glutamate receptor antagonists protect against ischemia-induced retinal damage.
    European journal of pharmacology, 1994, Dec-27, Volume: 271, Issue:2-3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Ischemia; Rats; Receptors,

1994
Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Abdomen; Animals; Baroreflex; Cats; Decerebrate State; Excitatory Amino

2002
Role of N-methyl-D-aspartate and opiate receptors in nociception during and after ischaemia in rats.
    Pain, 1992, Volume: 49, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Hot Temperature; Hyperalgesia; Ischemia; Male; Meperidine; Mor

1992
Implication of non-NMDA and NMDA receptors in cochlear ischemia.
    Neuroreport, 1992, Volume: 3, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cochlea; Dendrites; Guinea Pigs; Hair Cells, Auditory; Ischemi

1992
Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Sep-26, Volume: 32, Issue:39

    Topics: Anesthetics, Local; Animals; Bacterial Proteins; Carrier Proteins; Channelrhodopsins; Disease Models

2012
Selective sparing of hippocampal CA3 cells following in vitro ischemia is due to selective inhibition by acidosis.
    The European journal of neuroscience, 2005, Volume: 22, Issue:2

    Topics: Acidosis; Animals; Animals, Newborn; Calcium; Cell Death; Excitatory Amino Acid Antagonists; Excitat

2005
N-methyl-D-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia.
    Brain research, 1990, Jul-02, Volume: 522, Issue:1

    Topics: Animals; Anterior Horn Cells; Hindlimb; Injections, Spinal; Ischemia; Ketamine; Male; Pain; Physical

1990