prazosin has been researched along with Ischemia in 17 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the effect of Prazosin, an α1-Adrenergic receptor antagonist, was investigated on the liver injury induced by kidney ischemia-reperfusion (I/R) in rats." | 8.31 | Prazosin Protects the Liver Against Renal Ischemia/Reperfusion Injury in Rats. ( Aghajani, S; Bagheri, Y; Bahraminia, F; Jafari, E; Kakaei, F; Khajepour, F; Mahmoodpoor, F; Vahed, SZ, 2023) |
| "We report a case of ischemia limited to the upper limb caused by chronic use of ergotamine." | 7.71 | Successful treatment of threatening limb loss ischemia of the upper limb caused by ergotamine. A case report and review of the literature. ( Alanezi, KH; Cinà, CS; Safar, HA, 2002) |
| "Eighteen previously untreated primary hypertension patients were selected for therapy either with 50-250 mg/day metoprolol (n = 11) or with 3-20 mg/day prazosin (n = 8)." | 7.69 | Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension. ( Gretzer, I; Hjemdahl, P, 1997) |
| "Prazosin has shown protective effects against IR-injuries." | 5.72 | Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative Stress and Apoptotic Pathways After Renal Ischemia Reperfusion. ( Aghajani, S; Ahmadian, E; Bagheri, Y; Jeddi, M; Malekinejad, Z; Qahremani, R; Shahbazi, S, 2022) |
| " The FVC response following ischemia (14 min arterial occlusion with 3 min of hand exercise) was determined after systemic alpha 1-blockade (5 mg prazosin in preceding 24 h) in hypertensives (n = 11, MAP = 110 +/- 1, age = 24." | 5.08 | Effects of alpha 1-blockade on maximal vascular conductance in young borderline hypertensives. ( Franke, WD; Tegeler, NB, 1997) |
| " In this study, the effect of Prazosin, an α1-Adrenergic receptor antagonist, was investigated on the liver injury induced by kidney ischemia-reperfusion (I/R) in rats." | 4.31 | Prazosin Protects the Liver Against Renal Ischemia/Reperfusion Injury in Rats. ( Aghajani, S; Bagheri, Y; Bahraminia, F; Jafari, E; Kakaei, F; Khajepour, F; Mahmoodpoor, F; Vahed, SZ, 2023) |
| " This study was designed to compare middle cerebral artery mean blood velocity responses to acute hypotension with and without alpha(1)-adrenoreceptor blockade (Prazosin) in young, healthy humans." | 3.74 | Autonomic neural control of the cerebral vasculature: acute hypotension. ( Brothers, RM; Eubank, WL; Ogoh, S; Raven, PB, 2008) |
| "We report a case of ischemia limited to the upper limb caused by chronic use of ergotamine." | 3.71 | Successful treatment of threatening limb loss ischemia of the upper limb caused by ergotamine. A case report and review of the literature. ( Alanezi, KH; Cinà, CS; Safar, HA, 2002) |
| "Eighteen previously untreated primary hypertension patients were selected for therapy either with 50-250 mg/day metoprolol (n = 11) or with 3-20 mg/day prazosin (n = 8)." | 3.69 | Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension. ( Gretzer, I; Hjemdahl, P, 1997) |
| "Prazosin has shown protective effects against IR-injuries." | 1.72 | Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative Stress and Apoptotic Pathways After Renal Ischemia Reperfusion. ( Aghajani, S; Ahmadian, E; Bagheri, Y; Jeddi, M; Malekinejad, Z; Qahremani, R; Shahbazi, S, 2022) |
| "Ischemic acute renal failure was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy." | 1.34 | Selective antagonism of the postsynaptic alpha(1)-adrenoceptor is protective against ischemic acute renal failure in rats. ( Fujii, T; Kobuchi, S; Matsumura, Y; Ohkita, M; Sugiura, T; Takaoka, M, 2007) |
| "Prazosin (50 mg/l) was given in drinking water to animals with limited or intact blood supply." | 1.30 | The effect of alpha 1 adrenoceptor antagonist prazosin on capillary supply, blood flow and performance in a rat model of chronic muscle ischaemia. ( Collis, MG; Fulgenzi, G; Graciotti, L; Hudlická, O, 1998) |
| "Effect of alpha-adrenergic blockers on pulmonary edema in lung transplantation was studied with a rat model of syngeneic left lung transplantation." | 1.30 | Alpha-adrenergic blockade in preventing posttransplant edema of lung allograft. ( Fujimura, S; Horikoshi, A; Kondo, T; Matsumura, Y; Okada, Y; Shimada, K, 1999) |
| "Prazosin pretreatment (2." | 1.29 | Norepinephrine-induced sustained myocardial adaptation to ischemia is dependent on alpha 1-adrenoceptors and protein synthesis. ( Banerjee, A; Brown, JM; Cleveland, JC; Harken, AH; Meng, X; Mitchell, MB; Rowland, RT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Malekinejad, Z | 1 |
| Aghajani, S | 2 |
| Jeddi, M | 1 |
| Qahremani, R | 1 |
| Shahbazi, S | 1 |
| Bagheri, Y | 2 |
| Ahmadian, E | 1 |
| Khajepour, F | 1 |
| Mahmoodpoor, F | 1 |
| Jafari, E | 1 |
| Kakaei, F | 1 |
| Bahraminia, F | 1 |
| Vahed, SZ | 1 |
| Spradley, FT | 1 |
| Ge, Y | 1 |
| Haynes, BP | 1 |
| Granger, JP | 1 |
| Anderson, CD | 1 |
| Kaur, J | 1 |
| Machado, TM | 1 |
| Alvarez, A | 1 |
| Krishnan, AC | 1 |
| Hanna, HW | 1 |
| Altamimi, YH | 1 |
| Senador, D | 1 |
| Spranger, MD | 1 |
| O'Leary, DS | 1 |
| Fujii, T | 1 |
| Sugiura, T | 1 |
| Ohkita, M | 1 |
| Kobuchi, S | 1 |
| Takaoka, M | 1 |
| Matsumura, Y | 2 |
| Ogoh, S | 1 |
| Brothers, RM | 1 |
| Eubank, WL | 1 |
| Raven, PB | 1 |
| Cobaugh, DS | 1 |
| Sapienza, P | 1 |
| Edwards, JD | 1 |
| Mingoli, A | 1 |
| McGregor, PE | 1 |
| Cavallari, N | 1 |
| Agrawal, DK | 1 |
| Meng, X | 1 |
| Cleveland, JC | 1 |
| Rowland, RT | 1 |
| Mitchell, MB | 1 |
| Brown, JM | 1 |
| Banerjee, A | 1 |
| Harken, AH | 1 |
| Gretzer, I | 1 |
| Hjemdahl, P | 1 |
| Franke, WD | 1 |
| Tegeler, NB | 1 |
| Fulgenzi, G | 1 |
| Graciotti, L | 1 |
| Collis, MG | 1 |
| Hudlická, O | 1 |
| Kondo, T | 1 |
| Horikoshi, A | 1 |
| Fujimura, S | 1 |
| Okada, Y | 1 |
| Shimada, K | 1 |
| Eckert, RE | 1 |
| Karsten, AJ | 1 |
| Utz, J | 1 |
| Ziegler, M | 1 |
| Safar, HA | 1 |
| Alanezi, KH | 1 |
| Cinà, CS | 1 |
| Kim, YH | 1 |
| Chun, YS | 1 |
| Park, JW | 1 |
| Kim, CH | 1 |
| Kim, MS | 1 |
| Jansen, PF | 1 |
| Gribnau, FW | 1 |
| Schulte, BP | 1 |
1 trial available for prazosin and Ischemia
| Article | Year |
|---|---|
Effects of alpha 1-blockade on maximal vascular conductance in young borderline hypertensives.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Blood Pressure; Case-Control | 1997 |
16 other studies available for prazosin and Ischemia
| Article | Year |
|---|---|
Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative Stress and Apoptotic Pathways After Renal Ischemia Reperfusion.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Brain; Ischemia; Kidney; Oxidative Stress; Pr | 2022 |
Prazosin Protects the Liver Against Renal Ischemia/Reperfusion Injury in Rats.
Topics: Acute Kidney Injury; Animals; Ischemia; Kidney; Liver; Male; Oxidative Stress; Prazosin; Rats; Rats, | 2023 |
Adrenergic receptor blockade attenuates placental ischemia-induced hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Femal | 2018 |
Muscle metaboreflex activation during dynamic exercise vasoconstricts ischemic active skeletal muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Arterial Pressure; Do | 2015 |
Selective antagonism of the postsynaptic alpha(1)-adrenoceptor is protective against ischemic acute renal failure in rats.
Topics: Acute Kidney Injury; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; | 2007 |
Autonomic neural control of the cerebral vasculature: acute hypotension.
Topics: Administration, Oral; Adult; Autonomic Nervous System; Blood Pressure; Cerebrovascular Circulation; | 2008 |
Prazosin treatment of ergotamine-induced peripheral ischemia.
Topics: Adult; Arm; Ergotamine; Female; Humans; Ischemia; Leg; Migraine Disorders; Prazosin; Quinazolines | 1980 |
Ischemia-induced peripheral arterial vasospasm role of alpha 1- and alpha 2-adrenoceptors.
Topics: Animals; Dogs; Femoral Artery; Ischemia; Male; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine | 1996 |
Norepinephrine-induced sustained myocardial adaptation to ischemia is dependent on alpha 1-adrenoceptors and protein synthesis.
Topics: Adaptation, Physiological; Adrenergic alpha-1 Receptor Antagonists; Animals; Cycloheximide; Hemodyna | 1996 |
Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Catecholamines; Female; Forearm; H | 1997 |
The effect of alpha 1 adrenoceptor antagonist prazosin on capillary supply, blood flow and performance in a rat model of chronic muscle ischaemia.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Blood Pressure; Capillaries; Histologic | 1998 |
Alpha-adrenergic blockade in preventing posttransplant edema of lung allograft.
Topics: Adrenergic alpha-Antagonists; Animals; Drug Evaluation, Preclinical; Heart Failure; Hemodynamics; Is | 1999 |
Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; | 2000 |
Successful treatment of threatening limb loss ischemia of the upper limb caused by ergotamine. A case report and review of the literature.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Angiography; Arm; Arterial Occlusive Diseases; E | 2002 |
Involvement of adrenergic pathways in activation of catalase by myocardial ischemia-reperfusion.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Animals; Brain; Catalase | 2002 |
Comment: prazosin associated with stroke.
Topics: Cerebrovascular Disorders; Humans; Ischemia; Prazosin | 1988 |