helicide profile

helicide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	12896796
CHEMBL ID	201358
CHEBI ID	189486
SCHEMBL ID	17822698
MeSH ID	M0156615
PubMed CID	7573800
CHEMBL ID	461515
SCHEMBL ID	987981
MeSH ID	M0156615

Synonym
helicide
F0542
4-(beta-d-allopyranosyloxy)benzaldehyde
4-formylphenyl beta-d-allopyranoside
CHEMBL201358 ,
4-((2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-yloxy)benzaldehyde
4-((2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)benzaldehyde
bdbm50177404
4-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzaldehyde
CHEBI:189486
A839856
4-(((2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)benzaldehyde
S3797
AKOS025310966
4-(beta-d-allopyranosyloxy)-benzaldehyde
mfcd00210992
benzaldehyde, 4-(b-d-allopyranosyloxy)-
SCHEMBL17822698
4-formylphenyl b-d-allopyranoside
hilicidum
helicid,(s)
4-formylphenyl-o-b-d-allopyranoside
AS-30535
HMS3885A06
CS-0008901
CCG-267289
HY-N0343
helicide; helicidum;4-formylphenyl--d-allopyranoside
80154-34-3
4-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-yloxy)benzaldehyde
bdbm50245886
4-formylphenyl-o-beta-d-glucopyranoside
4-formylphenyl-o-beta-dglucopyranoside
4-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)benzaldehyde
CHEMBL461515 ,
4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzaldehyde
helicin hydrate
4'-formylphenyl-beta-d-glucopyranoside
4-formylphenyl b-d-glucopyranoside
4-(beta-d-glucopyranosyloxy)benzaldehyde
26993-16-8
AKOS015960450
N88424
SCHEMBL987981
Q-201187
W-202142
4-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)benzaldehyde
mfcd08704111
AC-7974
gastrodin impurity 1
AS-49890
A925039
4-formylphenyl-beta-d-glucopyranoside
4-formylphenyl \|a-d-glucopyranoside
CS-0139019
PD182179
(2s,3r,4s,5s,6r)-4-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-benzaldehyde

Excerpt	Reference	Relevance
" The method was successfully applied to a pharmacokinetic study in rats after intragastric administration of helicid with a dose of 50mg/kg."	( Quantitative determination of helicid in rat plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to preliminary pharmacokinetic studies. Dai, X; Jia, Y; Wang, G; Wang, R; Wang, W; Wang, Y; Xie, H; Xu, M; Yao, C, 2007)	0.34
"To report the pharmacokinetic parameters of helicid HD in rats after intravenous administration at different doses."	( [Investigation on pharmacokinetics of helicid in rats]. Chen, Z; Jiang, XH; Liu, TM; Ma, G; Ren, J; Wang, L, 2008)	0.35
" To facilitate pharmacokinetic studies of helicid in man, a sensitive and specific LC-MS/MS method for the quantitative detection of helicid in human plasma was developed and validated."	( LC-MS/MS determination of helicid in human plasma and its application in pharmacokinetic studies. Chen, R; Jia, Y; Shen, J; Sun, H; Tan, Z; Xie, H; Zhang, W; Zhou, H, 2011)	0.37
" Bioavailability and pharmacokinetic parameters of helicid in beagle dogs were researched from a two period crossover design study."	( Bioavailability and pharmacokinetics profile of helicid in beagle dogs using gradient elution high performance liquid chromatography electrospray ionization mass spectrometry. Jia, Y; Shen, J; Sun, J; Wang, W; Xie, H, 2015)	0.42

Excerpt	Reference	Relevance
" Bioavailability and pharmacokinetic parameters of helicid in beagle dogs were researched from a two period crossover design study."	( Bioavailability and pharmacokinetics profile of helicid in beagle dogs using gradient elution high performance liquid chromatography electrospray ionization mass spectrometry. Jia, Y; Shen, J; Sun, J; Wang, W; Xie, H, 2015)	0.42

Class	Description
glycoside	A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Polyphenol oxidase 2	Agaricus bisporus	IC50 (µMol)	2,540.0000	0.0340	3.9871	10.0000	AID411681
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50 (µMol)	0.4500	0.0000	0.9453	9.9400	AID383238
Acetylcholinesterase	Electrophorus electricus (electric eel)	Ki	0.7300	0.0012	1.2563	8.9000	AID383238
Polyphenol oxidase 2	Agaricus bisporus	IC50 (µMol)	940.0000	0.0340	3.9871	10.0000	AID411681; AID430880
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
succinate metabolic process	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
glutamate metabolic process	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
central nervous system development	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
gamma-aminobutyric acid catabolic process	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
post-embryonic development	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
synaptic transmission, GABAergic	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
response to hypoxia	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
copulation	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
locomotory behavior	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
response to xenobiotic stimulus	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
gamma-aminobutyric acid metabolic process	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
gamma-aminobutyric acid biosynthetic process	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
response to iron ion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
negative regulation of gamma-aminobutyric acid secretion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
cerebellum development	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
positive regulation of heat generation	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
positive regulation of insulin secretion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
negative regulation of dopamine secretion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
response to nicotine	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
exploration behavior	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
response to ethanol	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
negative regulation of blood pressure	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
positive regulation of dopamine metabolic process	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
behavioral response to cocaine	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
positive regulation of uterine smooth muscle contraction	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
positive regulation of inhibitory postsynaptic potential	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
positive regulation of prolactin secretion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
positive regulation of aspartate secretion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
gamma-aminobutyric acid catabolic process	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
succinate-semialdehyde dehydrogenase (NAD+) activity	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
identical protein binding	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
4-aminobutyrate transaminase activity	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
pyridoxal phosphate binding	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
succinate-semialdehyde dehydrogenase binding	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
4-aminobutyrate:2-oxoglutarate transaminase activity	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
identical protein binding	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
metal ion binding	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
(S)-3-amino-2-methylpropionate transaminase activity	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
iron-sulfur cluster binding	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
mitochondrion	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrial matrix	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
synapse	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrion	Succinate-semialdehyde dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
mitochondrial matrix	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
4-aminobutyrate transaminase complex	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
mitochondrion	4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (19)

Assay ID	Title	Year	Journal	Article
AID260087	Inhibitory activity against SSADH	2006	Bioorganic & medicinal chemistry letters, Feb, Volume: 16, Issue:3	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.
AID444074	Inhibition of mushroom tyrosinase at 200 uM	2009	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21	Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.
AID383242	Inhibition of horse serum BuChE upto 500 uM by Ellman's method	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.
AID1442887	Antiproliferative activity against human MCF7 cells by SRB assay	2017	Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8	Bioactive drimane sesquiterpenoids and aromatic glycosides from Cinnamosma fragrans.
AID455418	Inhibition of Torpedo california AChE at 1 mM by Ellman's method	2009	Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19	Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
AID411681	Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.
AID411682	Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation at 0.1 mM	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.
AID383241	Inhibition of Electrophorus electricus AChE upto 500 uM by Ellman's method	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.
AID260086	Inhibitory activity against GABAT	2006	Bioorganic & medicinal chemistry letters, Feb, Volume: 16, Issue:3	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.
AID383242	Inhibition of horse serum BuChE upto 500 uM by Ellman's method	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.
AID411681	Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.
AID411684	Toxicity in mouse assessed by autopsy at 1200 mg/kg, po administered as single gavage dose after 20 days	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.
AID1717384	Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry	2020	European journal of medicinal chemistry, Jan-15, Volume: 186	Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors.
AID411682	Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation at 0.1 mM	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.
AID1717383	Inhibition of rat FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substrate at 10 uM incubated for 10 mins by microplate reader	2020	European journal of medicinal chemistry, Jan-15, Volume: 186	Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors.
AID444074	Inhibition of mushroom tyrosinase at 200 uM	2009	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21	Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.
AID383238	Inhibition of Electrophorus electricus AChE by Ellman's method	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.
AID430880	Inhibition of diphenolase activity of mushroom tyrosinase	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.
AID411683	Toxicity in mouse assessed as mortality at 1200 mg/kg, po administered as single gavage dose after 20 days	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (7.41)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (37.04)	29.6817
2010's	10 (37.04)	24.3611
2020's	5 (18.52)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	25 (100.00%)	84.16%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxybenzyl alcohol 4-hydroxybenzyl alcohol: the aglycone of gastrodin. p-hydroxybenzyl alcohol : A member of the class of benzyl alcohols that is benzyl alcohol substituted by a hydroxy group at position 4. It has been isolated from Arcangelisia gusanlung.	2.03	1	benzyl alcohols; phenols	plant metabolite
4-hydroxybenzaldehyde [no description available]	2.95	4	hydroxybenzaldehyde	EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor; mouse metabolite; plant metabolite
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	2.03	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.02	1	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
4-aminobenzoic acid 4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.	2.03	1	aminobenzoic acid; aromatic amino-acid zwitterion	allergen; Escherichia coli metabolite; plant metabolite
vanillin Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).	2.03	1	benzaldehydes; monomethoxybenzene; phenols	anti-inflammatory agent; anticonvulsant; antioxidant; flavouring agent; plant metabolite
tacrine Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.	2.05	1	acridines; aromatic amine	EC 3.1.1.7 (acetylcholinesterase) inhibitor
corticosterone [no description available]	2.21	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
4-hydroxypropiophenone [no description available]	2.03	1	acetophenones
n-vinyl-2-pyrrolidinone N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source	2.05	1	pyrrolidin-2-ones
propylparaben Parabens: Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)	2.02	1	benzoate ester; paraben; phenols	antifungal agent; antimicrobial agent
4-hydroxyacetophenone 4-hydroxyacetophenone: promotes secretion of bile & bile salts, which promotes griseofulvin absorption in the duodenum. 4'-hydroxyacetophenone : A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.	2.03	1	monohydroxyacetophenone	fungal metabolite; mouse metabolite; plant metabolite
tropolone Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).. tropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.	2.05	1	alpha-hydroxy ketone; cyclic ketone; enol	bacterial metabolite; fungicide; toxin
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.15	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
4-anisaldehyde 4-anisaldehyde: RN given refers to cpd with specified locants for methoxy moieties; structure in Merck, 9th ed, #696. p-methoxybenzaldehyde : A member of the class of benzaldehydes consisting of benzaldehyde itself carrying a methoxy substituent at position 4.	2.03	1	benzaldehydes	bacterial metabolite; human urinary metabolite; insect repellent; plant metabolite
polygodial [no description available]	2.15	1	aldehyde
4-hydroxybenzylamine 4-hydroxybenzylamine: RN given refers to parent cpd	2.03	1	aromatic amine
gastrodin gastrodin: the glucoside of 4-hydroxybenzyl alcohol (gastrodigenin); isolated from Gastrodia elata Blume;	2.03	1	glycoside
razadyne Razadyne: Name of the FDA approved preparation from J&J.	2.04	1
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	2.45	2	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
glycosides [no description available]	2.04	1
physostigmine salicylate [no description available]	2.05	1	azaheterocycle salicylate salt; salicylates
4-methoxycinnamic acid [no description available]	2.04	1	cinnamic acids
thiosemicarbazide thiosemicarbazide: glutamate decarboxylase antagonist; structure given in first source. hydrazinecarbothioamide : A member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group.	1.97	1	hydrazines; thiocarboxamide; thioureas
sri 224 [no description available]	2.05	1
kelampayoside a kelampayoside A: a phenolic apioglucoside from the bark of Anthocephalus chinensis; structure given in first source	2.15	1	glycoside	metabolite
cinnamosmolide cinnamosmolide: isolated from several species of Canellaceae family; structure in first source	2.15	1
4-hydroxybenzaldehyde [no description available]	2.44	2	hydroxybenzaldehyde	EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor; mouse metabolite; plant metabolite
tropolone Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).. tropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.	2.05	1	alpha-hydroxy ketone; cyclic ketone; enol	bacterial metabolite; fungicide; toxin
zoledronic acid Zoledronic Acid: An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.. zoledronic acid : An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.	2.25	1	1,1-bis(phosphonic acid); imidazoles	bone density conservation agent
razadyne Razadyne: Name of the FDA approved preparation from J&J.	2.04	1
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	2.45	2	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
4-methoxycinnamic acid [no description available]	2.04	1	cinnamic acids
sri 224 [no description available]	2.05	1

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.74	3
Breast Cancer [description not available]	2.15	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.15	1
Acute Liver Injury, Drug-Induced [description not available]	2.25	1
Carbon Tetrachloride Poisoning Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	2.25	1
Innate Inflammatory Response [description not available]	2.66	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.66	2
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.25	1
Glial Cell Tumors [description not available]	2.25	1
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.9	3
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	2.93	3
Allodynia [description not available]	2.15	1
Chronic Insomnia [description not available]	2.15	1
Nerve Pain [description not available]	2.15	1
Sleep Initiation and Maintenance Disorders Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.	2.15	1
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	2.15	1

helicide

Description

Cross-References

Synonyms (57)

Research Excerpts

Pharmacokinetics

Bioavailability

Drug Classes (1)

Protein Targets (5)

Inhibition Measurements

Activation Measurements

Biological Processes (28)

Molecular Functions (9)

Ceullar Components (4)

Bioassays (19)

Research

Studies (27)

Market Indicators

Research Demand Index: 34.93

Study Types

helicide

Description

Cross-References

Synonyms (57)

Research Excerpts

Pharmacokinetics

Bioavailability

Drug Classes (1)

Protein Targets (5)

Inhibition Measurements

Activation Measurements

Biological Processes (28)

Molecular Functions (9)

Ceullar Components (4)

Bioassays (19)

Research

Studies (27)

Market Indicators

Research Demand Index: 34.93

Study Types

Related Drugs (34)

Related Conditions (17)