acetazolamide has been researched along with Allodynia in 8 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that inhibition of spinal CA activity with acetazolamide (ACT) reduces neuropathic allodynia." | 3.76 | Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. ( Asiedu, M; Kaila, K; Ossipov, MH; Price, TJ, 2010) |
| "The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling." | 1.51 | Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. ( De Koninck, Y; Gauthier, C; Lee, KY; Lorenzo, LE; Mapplebeck, JCS; Muley, MM; Prescott, SA; Salter, MW, 2019) |
| "Inflammation was induced in one hind paw of rats by intraplantar injection of carrageenan (250 μg)." | 1.36 | Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity? ( Bakhle, YS; de Francischi, JN; dos Reis, WG; Ferreira-Alves, DL; Gassani, BC; Paiva-Lima, P; Rezende, RM, 2010) |
| "Systemic ACTZ reversed the heat hyperalgesia but not mechanical allodynia." | 1.33 | Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats. ( Radhakrishnan, R; Sluka, KA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Nocentini, A | 1 |
| Alterio, V | 1 |
| Bua, S | 1 |
| Micheli, L | 1 |
| Esposito, D | 1 |
| Buonanno, M | 1 |
| Bartolucci, G | 1 |
| Osman, SM | 1 |
| ALOthman, ZA | 1 |
| Cirilli, R | 1 |
| Pierini, M | 1 |
| Monti, SM | 1 |
| Di Cesare Mannelli, L | 1 |
| Gratteri, P | 1 |
| Ghelardini, C | 1 |
| De Simone, G | 1 |
| Supuran, CT | 1 |
| Da Vitoria Lobo, ME | 1 |
| Weir, N | 1 |
| Hardowar, L | 1 |
| Al Ojaimi, Y | 1 |
| Madden, R | 1 |
| Gibson, A | 1 |
| Bestall, SM | 1 |
| Hirashima, M | 1 |
| Schaffer, CB | 1 |
| Donaldson, LF | 1 |
| Bates, DO | 1 |
| Hulse, RP | 1 |
| Potenzieri, A | 1 |
| Riva, B | 1 |
| Rigolio, R | 1 |
| Chiorazzi, A | 1 |
| Pozzi, E | 1 |
| Ballarini, E | 1 |
| Cavaletti, G | 1 |
| Genazzani, AA | 1 |
| Mapplebeck, JCS | 1 |
| Lorenzo, LE | 1 |
| Lee, KY | 2 |
| Gauthier, C | 1 |
| Muley, MM | 1 |
| De Koninck, Y | 1 |
| Prescott, SA | 2 |
| Salter, MW | 1 |
| Asiedu, M | 1 |
| Ossipov, MH | 1 |
| Kaila, K | 1 |
| Price, TJ | 1 |
| Gassani, BC | 1 |
| Rezende, RM | 1 |
| Paiva-Lima, P | 1 |
| Ferreira-Alves, DL | 1 |
| dos Reis, WG | 1 |
| Bakhle, YS | 1 |
| de Francischi, JN | 1 |
| Radhakrishnan, R | 1 |
| Sluka, KA | 1 |
8 other studies available for acetazolamide and Allodynia
| Article | Year |
|---|---|
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.
Topics: Animals; Antineoplastic Agents; Benzenesulfonamides; Carbonic Anhydrase II; Carbonic Anhydrase Inhib | 2020 |
Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain.
Topics: Acetazolamide; Animals; Carbonic Anhydrases; Glucose Transport Proteins, Facilitative; Hyperalgesia; | 2022 |
Oxaliplatin-induced neuropathy occurs through impairment of haemoglobin proton buffering and is reversed by carbonic anhydrase inhibitors.
Topics: Acetazolamide; Animals; Antineoplastic Agents; Buffers; Carbonic Anhydrase Inhibitors; Ganglia, Spin | 2020 |
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides; | 2019 |
Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade.
Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides; | 2015 |
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.
Topics: Acetazolamide; Anesthetics, Intravenous; Animals; Carbonic Anhydrase Inhibitors; Disease Models, Ani | 2010 |
Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?
Topics: Acetazolamide; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationsh | 2010 |
Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats.
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Carrageenan; Dose-Response Relationship, Drug | 2005 |