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tolmetin and Allodynia

tolmetin has been researched along with Allodynia in 5 studies

Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.

Research Excerpts

ExcerptRelevanceReference
" Footpad PG levels returned to base line or below within 5 min of dosing with ketorolac, which suggests rapid turnover of PG in the inflamed tissue."1.30Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. ( Isakson, PC; Portanova, J; Seibert, K; Shaffer, A; Zhang, Y, 1997)
"Tactile allodynia was assessed 7 days after the surgery by measuring hindpaw withdrawal threshold to probing with von Frey filaments."1.30Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. ( Hunter, JC; Lashbrook, JM; Ossipov, MH; Porreca, F; Raffa, RB; Tallarida, RJ, 1999)
"Pretreatment with ketorolac had a selective effect on the postburn injury hyperalgesia, reducing the increase in pain intensity (P<0."1.29Reduction of postburn hyperalgesia after local injection of ketorolac in healthy volunteers. ( Brull, SJ; Collins, JG; Kitahata, LM; LaMotte, R; Lundell, JC; O'Connor, TZ; Silverman, DG, 1996)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Møiniche, S1
Pedersen, JL1
Kehlet, H1
Lundell, JC1
Silverman, DG1
Brull, SJ1
O'Connor, TZ1
Kitahata, LM1
Collins, JG1
LaMotte, R1
Zhang, Y1
Shaffer, A1
Portanova, J1
Seibert, K1
Isakson, PC1
Southall, DM1
Michael, LR1
Vasko, RM1
Lashbrook, JM1
Ossipov, MH1
Hunter, JC1
Raffa, RB1
Tallarida, RJ1
Porreca, F1

Trials

1 trial available for tolmetin and Allodynia

ArticleYear
Topical ketorolac has no antinociceptive or anti-inflammatory effect in thermal injury.
    Burns : journal of the International Society for Burn Injuries, 1994, Volume: 20, Issue:6

    Topics: Administration, Topical; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; B

1994

Other Studies

4 other studies available for tolmetin and Allodynia

ArticleYear
Reduction of postburn hyperalgesia after local injection of ketorolac in healthy volunteers.
    Anesthesiology, 1996, Volume: 84, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Burns; Humans; Hyperalgesia; Injections, Intrad

1996
Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3

    Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Hyperalgesia; Inflammation; Ketorolac; Male; Rats;

1997
Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.
    Pain, 1998, Volume: 78, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclooxygenase Inhibitors; Freund's Adj

1998
Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats.
    Pain, 1999, Volume: 82, Issue:1

    Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Hyperalgesia; Injections, Sp

1999