tolmetin has been researched along with Allodynia in 5 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Footpad PG levels returned to base line or below within 5 min of dosing with ketorolac, which suggests rapid turnover of PG in the inflamed tissue." | 1.30 | Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. ( Isakson, PC; Portanova, J; Seibert, K; Shaffer, A; Zhang, Y, 1997) |
| "Tactile allodynia was assessed 7 days after the surgery by measuring hindpaw withdrawal threshold to probing with von Frey filaments." | 1.30 | Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. ( Hunter, JC; Lashbrook, JM; Ossipov, MH; Porreca, F; Raffa, RB; Tallarida, RJ, 1999) |
| "Pretreatment with ketorolac had a selective effect on the postburn injury hyperalgesia, reducing the increase in pain intensity (P<0." | 1.29 | Reduction of postburn hyperalgesia after local injection of ketorolac in healthy volunteers. ( Brull, SJ; Collins, JG; Kitahata, LM; LaMotte, R; Lundell, JC; O'Connor, TZ; Silverman, DG, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Møiniche, S | 1 |
| Pedersen, JL | 1 |
| Kehlet, H | 1 |
| Lundell, JC | 1 |
| Silverman, DG | 1 |
| Brull, SJ | 1 |
| O'Connor, TZ | 1 |
| Kitahata, LM | 1 |
| Collins, JG | 1 |
| LaMotte, R | 1 |
| Zhang, Y | 1 |
| Shaffer, A | 1 |
| Portanova, J | 1 |
| Seibert, K | 1 |
| Isakson, PC | 1 |
| Southall, DM | 1 |
| Michael, LR | 1 |
| Vasko, RM | 1 |
| Lashbrook, JM | 1 |
| Ossipov, MH | 1 |
| Hunter, JC | 1 |
| Raffa, RB | 1 |
| Tallarida, RJ | 1 |
| Porreca, F | 1 |
1 trial available for tolmetin and Allodynia
| Article | Year |
|---|---|
Topical ketorolac has no antinociceptive or anti-inflammatory effect in thermal injury.
Topics: Administration, Topical; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; B | 1994 |
4 other studies available for tolmetin and Allodynia
| Article | Year |
|---|---|
Reduction of postburn hyperalgesia after local injection of ketorolac in healthy volunteers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Burns; Humans; Hyperalgesia; Injections, Intrad | 1996 |
Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Hyperalgesia; Inflammation; Ketorolac; Male; Rats; | 1997 |
Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclooxygenase Inhibitors; Freund's Adj | 1998 |
Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Hyperalgesia; Injections, Sp | 1999 |