quinacrine has been researched along with Allodynia in 2 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechanical hyperalgesia was produced in the nucleus pulposus group and after injection of N theta-nitro-L-arginine methyl ester in the nucleus pulposus+anulus fibrosus group, both of which returned to normal after mepacrine injection." | 1.30 | The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat. ( Hashizume, H; Kawakami, M; Meller, ST; Tamaki, T; Weinstein, JN, 1997) |
| "Norepinephrine does not produce hyperalgesia in untreated skin, but in chloroform pretreated skin or in the presence of the calcium ionophore A23187, norepinephrine produces a potent dose-dependent hyperalgesia." | 1.28 | Characterization of distinct phospholipases mediating bradykinin and noradrenaline hyperalgesia. ( Heller, PH; Levine, JD; Taiwo, YO, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawakami, M | 1 |
| Tamaki, T | 1 |
| Hashizume, H | 1 |
| Weinstein, JN | 1 |
| Meller, ST | 1 |
| Taiwo, YO | 1 |
| Heller, PH | 1 |
| Levine, JD | 1 |
2 other studies available for quinacrine and Allodynia
| Article | Year |
|---|---|
The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat.
Topics: Animals; Enzyme Inhibitors; Hyperalgesia; Intervertebral Disc; Intervertebral Disc Displacement; Mal | 1997 |
Characterization of distinct phospholipases mediating bradykinin and noradrenaline hyperalgesia.
Topics: Aminoquinolines; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Fluorescent D | 1990 |