glycine has been researched along with Allodynia in 67 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain." | 8.31 | AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023) |
| " Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia." | 7.85 | Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017) |
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 7.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| " The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain." | 7.75 | Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009) |
| "Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats." | 7.73 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| "Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine." | 7.70 | Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000) |
| ") strychnine (STR) produces reversible, segmentally localized allodynia in the rat." | 7.70 | Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. ( Khandwala, H; Loomis, CW, 1998) |
| " We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice." | 7.69 | Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997) |
| " We have studied the effects on mechanical nociceptive thresholds in rats with carrageenin-induced paw inflammation of L-687,414, a low efficacy partial agonist which acts as a functional antagonist at the glycine modulatory site of the NMDA receptor and of L-701,324, a structurally novel, highly selective, full antagonist at this site." | 7.69 | Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats. ( Hargreaves, RJ; Hill, RG; Laird, JM; Mason, GS; Webb, J, 1996) |
| "Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery." | 5.42 | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015) |
| "Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)." | 5.39 | Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013) |
| "Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy." | 5.35 | Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia. ( Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL, 2009) |
| " The analgesic activity of CHF3381 was investigated in the heat-capsaicin human pain model and compared with those of gabapentin." | 5.12 | CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model. ( Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O, 2006) |
| "Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain." | 4.31 | AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023) |
| " Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia." | 3.85 | Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017) |
| " In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema." | 3.80 | Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. ( Alfonso, S; Anzini, M; Battilocchio, C; Biava, M; Calderone, V; Colovic, M; Consalvi, S; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Persiani, S; Poce, G; Rossi, A; Sautebin, L; Testai, L, 2014) |
| "Glycine inhibitory dysfunction provides a useful experimental model for studying the mechanism of dynamic mechanical allodynia, a widespread and intractable symptom of neuropathic pain." | 3.77 | Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. ( Dallel, R; Miraucourt, LS; Peirs, C; Voisin, DL, 2011) |
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 3.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| " After recovery, rats received injections of lidocaine, GABA and glycine agonists or antagonists and their effects were assessed on behavioral tests of allodynia and hyperalgesia." | 3.76 | Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats. ( Al Amin, H; Atweh, SF; Jabbur, SJ; Saadé, NE; Tchachaghian, S, 2010) |
| " The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain." | 3.75 | Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009) |
| " This efficient route enabled to scale up the synthesis of an orally bioavailable glycine antagonist showing outstanding in vivo anti-hyperalgesic activity in different animal models of sustained inflammation and chronic neuropathic pain." | 3.74 | Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain. ( Alvaro, G; Barnaby, RJ; Bertani, B; Corsi, M; Di Fabio, R; Donati, D; Gentile, G; Giacobbe, S; Pentassuglia, G; Pizzi, DM; Quartaroli, M; Ratti, E; Spada, S; Vitulli, G, 2007) |
| "In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception." | 3.74 | Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007) |
| "Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats." | 3.73 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| "GABA and glycine are inhibitory neurotransmitters used by many neurons in the spinal dorsal horn, and intrathecal administration of GABA(A) and glycine receptor antagonists produces behavioural signs of allodynia, suggesting that these transmitters have an important role in spinal pain mechanisms." | 3.72 | Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain. ( Hughes, DI; Maxwell, DJ; Polgár, E; Puskár, Z; Riddell, JS; Todd, AJ, 2003) |
| ") treatment (twice-daily injections on post-operative (PO) days 0-8) with the metabotropic glutamate receptor (mGluR) compound, (S)-4-carboxyphenylglycine ((S)-4CPG), or the non-competitive N-methyl-D-aspartate (NMDA) antagonist, dizocilipine maleate (MK-801), on mechanical allodynia and cold hyperalgesia associated with chronic constriction injury (CCI) of the sciatic nerve in rats." | 3.70 | Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. ( Cahill, CM; Coderre, TJ; Fisher, K; Fundytus, ME, 1998) |
| ") strychnine (STR) produces reversible, segmentally localized allodynia in the rat." | 3.70 | Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. ( Khandwala, H; Loomis, CW, 1998) |
| "Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine." | 3.70 | Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000) |
| " We have studied the effects on mechanical nociceptive thresholds in rats with carrageenin-induced paw inflammation of L-687,414, a low efficacy partial agonist which acts as a functional antagonist at the glycine modulatory site of the NMDA receptor and of L-701,324, a structurally novel, highly selective, full antagonist at this site." | 3.69 | Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats. ( Hargreaves, RJ; Hill, RG; Laird, JM; Mason, GS; Webb, J, 1996) |
| " We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice." | 3.69 | Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997) |
| "The PTX-induced thermal hyperalgesia peaked between day 2 and 4, but no cold allodynia is observed; i." | 2.42 | Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome. ( Chang, YC; Wen, ZH; Wong, CS, 2003) |
| "However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment." | 1.62 | Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model. ( Al-Khrasani, M; Balogh, M; Barsi, S; Benyhe, S; Galambos, AR; Harsing, LG; Karádi, DÁ; Király, K; Köles, L; Lakatos, PP; Mohammadzadeh, A; Riba, P; Szökő, É; Tábi, T; Zádor, F; Zádori, ZS, 2021) |
| "MCS reversed the hyperalgesia induced by peripheral neuropathy in the rats with chronic sciatic nerve constriction and induced a significant increase in the glycine and GABA levels in the PAG in comparison with the naive and sham-treated rats." | 1.51 | Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain. ( Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL, 2019) |
| "Treatment with SR9009 also blocked tumor necrosis factor-induced IL-1β mRNA, IL-6 mRNA and MMP-9 mRNA." | 1.51 | Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice. ( Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF, 2019) |
| "Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome." | 1.48 | Endogenous H ( Bo, Q; Cui, J; Du, J; Shi, B; Wang, W; Wang, Y; Yu, X; Zhao, H; Zhu, K; Zhu, Y, 2018) |
| "Neuropathic pain is an integral component of several chronic pain conditions and poses a major health problem worldwide." | 1.46 | Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component. ( Bali, KK; Kuner, R, 2017) |
| "Mechanical hyperalgesia induced by (R,S)-3,5-dihydroxyphenylglycine (DHPG), an mGlu1/5 agonist, in the masseter muscle was attenuated by AMG9810, a specific TRPV1 antagonist." | 1.42 | Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat. ( Chung, MK; Joseph, J; Lee, J; Ro, JY; Saloman, J, 2015) |
| "Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery." | 1.42 | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015) |
| "Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)." | 1.39 | Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013) |
| "Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor." | 1.36 | The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. ( Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS, 2010) |
| "In vivo testing in a rodent model of neuropathic pain indicated one amino acid significantly and dose-dependently decreased mechanical allodynia." | 1.36 | A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. ( Abell, AD; Avery, TD; Bräuner-Osborne, H; Hutchinson, MR; Irvine, RJ; Kvist, T; Mathiesen, JM; Nielsen, B; Pedersen, DS; Stanley, NJ; Taylor, DK; Tiekink, ER, 2010) |
| "Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy." | 1.35 | Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia. ( Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL, 2009) |
| "The NAGly induced anti-allodynia was dose dependent and, unlike HU-210, was unaffected by the cannabinoid CB(1) and CB(2) receptor antagonists, AM251 and SR144528 (30 nmol)." | 1.35 | Actions of N-arachidonyl-glycine in a rat neuropathic pain model. ( Mitchell, VA; Vaughan, CW; Vuong, LA, 2008) |
| "Morphine tolerance was induced in mice by implanting a 75 mg morphine pellet and assessing morphine-induced antinociception 72-h later." | 1.35 | mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo. ( Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL, 2008) |
| "TENS reduces hyperalgesia through activation of receptor-mediated pathways at the level of the spinal cord, and supraspinally." | 1.34 | Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats. ( Lisi, TL; Maeda, Y; Sluka, KA; Vance, CG, 2007) |
| " Unlike morphine, CHF3381 chronic administration was not accompanied by the development of tolerance in the formalin test." | 1.32 | Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. ( Barbieri, M; Bassani, F; Bergamaschi, M; Bolzoni, PT; Chamiot-Clerc, P; Maiorino, M; Pietra, C; Rondelli, I; Simonato, M; Villetti, G, 2003) |
| "Pertussis toxin injection induced thermal hyperalgesia which peaked between day 2 and 4; no cold allodynia was observed." | 1.32 | Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids. ( Chang, YC; Chen, JY; Hsing, CH; Wang, JJ; Wen, ZH; Wong, CS; Yang, LC, 2003) |
| "Glycine is a candidate nociception inhibitory transmitter in specific brain regions, like for example the spinal cord, the thalamic nuclei and the periaqueductal gray matter." | 1.31 | Effects of persistent nociception on periaqueductal gray glycine release. ( Berrino, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Trabace, L, 2000) |
| "Skin hyperalgesia persisted for at least 30 minutes in both strychnine and glycine treated rats." | 1.27 | Hyperalgesia induced by altered glycinergic activity at the spinal cord. ( Beyer, C; Komisaruk, BR; Roberts, LA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.49) | 18.7374 |
| 1990's | 7 (10.45) | 18.2507 |
| 2000's | 30 (44.78) | 29.6817 |
| 2010's | 26 (38.81) | 24.3611 |
| 2020's | 3 (4.48) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Ding, Z | 1 |
| Xu, W | 1 |
| He, L | 1 |
| Huang, J | 2 |
| Zhang, C | 1 |
| Guo, Q | 1 |
| Zou, W | 1 |
| Wang, HC | 1 |
| Cheng, KI | 1 |
| Tseng, KY | 1 |
| Kwan, AL | 1 |
| Chang, LL | 1 |
| Garattini, EG | 1 |
| Santos, BM | 1 |
| Ferrari, DP | 1 |
| Capel, CP | 1 |
| Francescato, HDC | 1 |
| Coimbra, TM | 1 |
| Leite-Panissi, CRA | 1 |
| Branco, LGS | 1 |
| Nascimento, GC | 1 |
| Mohammadzadeh, A | 2 |
| Lakatos, PP | 1 |
| Balogh, M | 2 |
| Zádor, F | 1 |
| Karádi, DÁ | 1 |
| Zádori, ZS | 2 |
| Király, K | 2 |
| Galambos, AR | 1 |
| Barsi, S | 2 |
| Riba, P | 1 |
| Benyhe, S | 1 |
| Köles, L | 2 |
| Tábi, T | 1 |
| Szökő, É | 1 |
| Harsing, LG | 2 |
| Al-Khrasani, M | 2 |
| Honda, K | 2 |
| Shinoda, M | 2 |
| Kondo, M | 1 |
| Shimizu, K | 1 |
| Yonemoto, H | 1 |
| Otsuki, K | 1 |
| Akasaka, R | 1 |
| Furukawa, A | 2 |
| Iwata, K | 2 |
| Bali, KK | 1 |
| Kuner, R | 1 |
| Wang, W | 1 |
| Bo, Q | 1 |
| Du, J | 1 |
| Yu, X | 1 |
| Zhu, K | 1 |
| Cui, J | 1 |
| Zhao, H | 1 |
| Wang, Y | 2 |
| Shi, B | 1 |
| Zhu, Y | 1 |
| Shi, Y | 1 |
| Chen, Y | 2 |
| de Andrade, EM | 1 |
| Martinez, RCR | 1 |
| Pagano, RL | 1 |
| Lopes, PSS | 1 |
| Auada, AVV | 1 |
| Gouveia, FV | 1 |
| Antunes, GF | 1 |
| Assis, DV | 1 |
| Lebrun, I | 1 |
| Fonoff, ET | 1 |
| Morioka, N | 1 |
| Kodama, K | 1 |
| Tomori, M | 1 |
| Yoshikawa, K | 1 |
| Saeki, M | 1 |
| Nakamura, Y | 1 |
| Zhang, FF | 1 |
| Hisaoka-Nakashima, K | 1 |
| Nakata, Y | 1 |
| Hajnal, B | 1 |
| Velasco-Xolalpa, ME | 1 |
| Barragán-Iglesias, P | 1 |
| Roa-Coria, JE | 1 |
| Godínez-Chaparro, B | 1 |
| Flores-Murrieta, FJ | 1 |
| Torres-López, JE | 1 |
| Araiza-Saldaña, CI | 1 |
| Navarrete, A | 1 |
| Rocha-González, HI | 1 |
| Biava, M | 1 |
| Battilocchio, C | 1 |
| Poce, G | 1 |
| Alfonso, S | 1 |
| Consalvi, S | 1 |
| Di Capua, A | 1 |
| Calderone, V | 1 |
| Martelli, A | 1 |
| Testai, L | 1 |
| Sautebin, L | 1 |
| Rossi, A | 1 |
| Ghelardini, C | 1 |
| Di Cesare Mannelli, L | 1 |
| Giordani, A | 1 |
| Persiani, S | 1 |
| Colovic, M | 1 |
| Dovizio, M | 1 |
| Patrignani, P | 1 |
| Anzini, M | 1 |
| Chirila, AM | 1 |
| Brown, TE | 1 |
| Bishop, RA | 1 |
| Bellono, NW | 1 |
| Pucci, FG | 1 |
| Kauer, JA | 1 |
| Chung, MK | 1 |
| Lee, J | 1 |
| Joseph, J | 1 |
| Saloman, J | 1 |
| Ro, JY | 1 |
| Foster, E | 1 |
| Wildner, H | 1 |
| Tudeau, L | 1 |
| Haueter, S | 1 |
| Ralvenius, WT | 1 |
| Jegen, M | 1 |
| Johannssen, H | 1 |
| Hösli, L | 1 |
| Haenraets, K | 1 |
| Ghanem, A | 1 |
| Conzelmann, KK | 1 |
| Bösl, M | 1 |
| Zeilhofer, HU | 3 |
| Ohashi, N | 1 |
| Sasaki, M | 1 |
| Ohashi, M | 1 |
| Kamiya, Y | 1 |
| Baba, H | 1 |
| Kohno, T | 1 |
| Watson, CJ | 1 |
| Govea, RM | 1 |
| Zhou, S | 1 |
| Carlton, SM | 1 |
| Takazawa, T | 1 |
| Choudhury, P | 1 |
| Tong, CK | 1 |
| Conway, CM | 1 |
| Scherrer, G | 1 |
| Flood, PD | 1 |
| Mukai, J | 1 |
| MacDermott, AB | 1 |
| Nishimura, S | 1 |
| Fukushima, O | 1 |
| Ishikura, H | 1 |
| Takahashi, T | 1 |
| Matsunami, M | 1 |
| Tsujiuchi, T | 1 |
| Sekiguchi, F | 1 |
| Naruse, M | 1 |
| Kamanaka, Y | 1 |
| Kawabata, A | 1 |
| Miraucourt, LS | 2 |
| Moisset, X | 1 |
| Dallel, R | 2 |
| Voisin, DL | 2 |
| Hermanns, H | 1 |
| Muth-Selbach, U | 2 |
| Lipfert, P | 2 |
| Braun, S | 1 |
| Werdehausen, R | 1 |
| Bauer, I | 1 |
| Potvin, S | 1 |
| Larouche, A | 1 |
| Normand, E | 1 |
| de Souza, JB | 1 |
| Gaumond, I | 1 |
| Grignon, S | 1 |
| Marchand, S | 1 |
| Barbara, G | 1 |
| Alloui, A | 1 |
| Nargeot, J | 1 |
| Lory, P | 1 |
| Eschalier, A | 1 |
| Bourinet, E | 1 |
| Chemin, J | 1 |
| Saadé, NE | 1 |
| Al Amin, H | 1 |
| Tchachaghian, S | 1 |
| Jabbur, SJ | 1 |
| Atweh, SF | 1 |
| Stanley, NJ | 1 |
| Hutchinson, MR | 1 |
| Kvist, T | 1 |
| Nielsen, B | 1 |
| Mathiesen, JM | 1 |
| Bräuner-Osborne, H | 1 |
| Avery, TD | 1 |
| Tiekink, ER | 1 |
| Pedersen, DS | 1 |
| Irvine, RJ | 1 |
| Abell, AD | 1 |
| Taylor, DK | 1 |
| Lee, IO | 2 |
| Lim, ES | 2 |
| Rondon, ES | 1 |
| Vieira, AS | 1 |
| Valadão, CA | 1 |
| Parada, CA | 1 |
| Kodama, D | 1 |
| Ono, H | 1 |
| Tanabe, M | 1 |
| Peirs, C | 1 |
| Son, JK | 1 |
| Kim, YS | 1 |
| Andersson, DA | 1 |
| Gentry, C | 1 |
| Bevan, S | 1 |
| Liu, MG | 1 |
| Matsuura, S | 1 |
| Suzuki, I | 1 |
| Shibuta, K | 1 |
| Tamagawa, T | 1 |
| Katagiri, A | 1 |
| Kiyomoto, M | 1 |
| Ohara, K | 1 |
| Urata, K | 1 |
| Wen, ZH | 2 |
| Yang, LC | 1 |
| Wang, JJ | 1 |
| Chang, YC | 2 |
| Hsing, CH | 1 |
| Chen, JY | 1 |
| Wong, CS | 2 |
| Villetti, G | 2 |
| Bergamaschi, M | 2 |
| Bassani, F | 2 |
| Bolzoni, PT | 1 |
| Maiorino, M | 1 |
| Pietra, C | 1 |
| Rondelli, I | 1 |
| Chamiot-Clerc, P | 1 |
| Simonato, M | 1 |
| Barbieri, M | 1 |
| Polgár, E | 1 |
| Hughes, DI | 1 |
| Riddell, JS | 1 |
| Maxwell, DJ | 1 |
| Puskár, Z | 1 |
| Todd, AJ | 1 |
| Dybek, E | 1 |
| Kollosche, K | 1 |
| Stegmann, JU | 1 |
| Holthusen, H | 1 |
| Shimoyama, N | 1 |
| Shimoyama, M | 1 |
| Davis, AM | 1 |
| Monaghan, DT | 1 |
| Inturrisi, CE | 1 |
| Reinold, H | 1 |
| Ahmadi, S | 1 |
| Depner, UB | 1 |
| Layh, B | 1 |
| Heindl, C | 1 |
| Hamza, M | 1 |
| Pahl, A | 1 |
| Brune, K | 1 |
| Narumiya, S | 1 |
| Müller, U | 1 |
| Price, TJ | 1 |
| Cervero, F | 1 |
| de Koninck, Y | 1 |
| Tonino Bolzoni, P | 1 |
| Mathiesen, O | 1 |
| Imbimbo, BP | 1 |
| Hilsted, KL | 1 |
| Fabbri, L | 1 |
| Dahl, JB | 1 |
| Ambrosini, SS | 1 |
| Coderre, TJ | 3 |
| Marabese, I | 3 |
| de Novellis, V | 2 |
| Palazzo, E | 3 |
| Scafuro, MA | 1 |
| Vita, D | 2 |
| Rossi, F | 4 |
| Maione, S | 3 |
| Eaton, MJ | 1 |
| Wolfe, SQ | 1 |
| Martinez, M | 1 |
| Hernandez, M | 1 |
| Furst, C | 1 |
| Frydel, BR | 1 |
| Gómez-Marín, O | 1 |
| Di Fabio, R | 1 |
| Alvaro, G | 1 |
| Bertani, B | 1 |
| Donati, D | 1 |
| Pizzi, DM | 1 |
| Gentile, G | 1 |
| Pentassuglia, G | 1 |
| Giacobbe, S | 1 |
| Spada, S | 1 |
| Ratti, E | 1 |
| Corsi, M | 1 |
| Quartaroli, M | 1 |
| Barnaby, RJ | 1 |
| Vitulli, G | 1 |
| Maeda, Y | 1 |
| Lisi, TL | 1 |
| Vance, CG | 1 |
| Sluka, KA | 1 |
| Gabra, BH | 2 |
| Kessler, FK | 1 |
| Ritter, JK | 1 |
| Dewey, WL | 2 |
| Smith, FL | 2 |
| Starowicz, K | 1 |
| Cristino, L | 1 |
| Gatta, L | 1 |
| Guida, F | 1 |
| Di Marzo, V | 1 |
| Vuong, LA | 1 |
| Mitchell, VA | 1 |
| Vaughan, CW | 1 |
| Navarro, HA | 1 |
| Carroll, FI | 1 |
| Laird, JM | 1 |
| Mason, GS | 1 |
| Webb, J | 1 |
| Hill, RG | 1 |
| Hargreaves, RJ | 1 |
| Satoh, O | 1 |
| Omote, K | 1 |
| Simpson, RK | 2 |
| Gondo, M | 1 |
| Robertson, CS | 1 |
| Goodman, JC | 1 |
| Minami, T | 1 |
| Okuda-Ashitaka, E | 1 |
| Nishizawa, M | 1 |
| Mori, H | 1 |
| Ito, S | 1 |
| Fisher, K | 2 |
| Fundytus, ME | 1 |
| Cahill, CM | 1 |
| Khandwala, H | 1 |
| Loomis, CW | 1 |
| Huang, W | 1 |
| Berrino, L | 1 |
| Trabace, L | 1 |
| Zhang, L | 1 |
| Lu, Y | 1 |
| Westlund, KN | 1 |
| Mills, CD | 1 |
| Johnson, KM | 1 |
| Hulsebosch, CE | 1 |
| García-Martinez, C | 1 |
| Humet, M | 1 |
| Planells-Cases, R | 1 |
| Gomis, A | 1 |
| Caprini, M | 1 |
| Viana, F | 1 |
| De La Pena, E | 1 |
| Sanchez-Baeza, F | 1 |
| Carbonell, T | 1 |
| De Felipe, C | 1 |
| Pérez-Paya, E | 1 |
| Belmonte, C | 1 |
| Messeguer, A | 1 |
| Ferrer-Montiel, A | 1 |
| Somers, DL | 1 |
| Clemente, FR | 1 |
| Beyer, C | 1 |
| Roberts, LA | 1 |
| Komisaruk, BR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for glycine and Allodynia
| Article | Year |
|---|---|
Glycine transporter inhibitors: A new avenue for managing neuropathic pain.
Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Hyperalgesia; Neuralgia; Neuro | 2019 |
Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acids; Glycine; Hyperalgesia; Injections, Spinal; | 2003 |
Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia.
Topics: Analgesics; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; K Cl- Cotransporters; Pain; Posterior Ho | 2005 |
1 trial available for glycine and Allodynia
| Article | Year |
|---|---|
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind | 2006 |
63 other studies available for glycine and Allodynia
| Article | Year |
|---|---|
Botulinum toxin type A counteracts neuropathic pain by countering the increase of GlyT2 expression in the spinal cord of CCI rats.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Crush Injuries; Glycine; Glycine Plasma Membrane Tran | 2022 |
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats.
Topics: Animals; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Glycine; Human | 2023 |
Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model.
Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Hyperalge | 2019 |
Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model.
Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Hyperalgesia; Male; Motor Activity; Ne | 2021 |
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
Topics: Acetanilides; Animals; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Glutamic Acid; | 2017 |
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
Topics: Analgesics; Animals; Cancer Pain; Chronic Pain; Cyclic S-Oxides; Disease Models, Animal; Female; Gly | 2017 |
Endogenous H
Topics: Alkynes; Aminooxyacetic Acid; Analgesics; Animals; Cell Line; Cystathionine gamma-Lyase; Cystitis, I | 2018 |
Kir2.1 Channel Regulation of Glycinergic Transmission Selectively Contributes to Dynamic Mechanical Allodynia in a Mouse Model of Spared Nerve Injury.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hyperalgesia; Imidazoles; Inhibitory Postsyna | 2019 |
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.
Topics: Analgesia; Animals; Bicuculline; Deep Brain Stimulation; Efferent Pathways; GABA Antagonists; gamma- | 2019 |
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice.
Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Infl | 2019 |
Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats.
Topics: Algorithms; Alkynes; Animals; Blood Glucose; Cystathionine gamma-Lyase; Cysteine; Data Interpretatio | 2013 |
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Topics: Acetic Acid; Amides; Animals; Carrageenan; Cell Line; Constriction, Pathologic; Cyclooxygenase 2; Cy | 2014 |
Long-term potentiation of glycinergic synapses triggered by interleukin 1β.
Topics: Animals; Behavior, Animal; GABAergic Neurons; Glycine; Hyperalgesia; Interleukin-1beta; Interneurons | 2014 |
Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat.
Topics: A Kinase Anchor Proteins; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Disease Mo | 2015 |
Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.
Topics: Animals; Disease Models, Animal; Glycine; Hyperalgesia; Mice; Mice, Transgenic; Nerve Net; Neurons; | 2015 |
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn.
Topics: Animals; Behavior, Animal; Biomarkers; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases | 2015 |
Insular balance of glutamatergic and GABAergic signaling modulates pain processing.
Topics: Analysis of Variance; Animals; Avoidance Learning; Cerebral Cortex; Disease Models, Animal; Excitato | 2016 |
Group III mGluR8 negatively modulates TRPA1.
Topics: Animals; Benzoates; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Excitatory Amino | 2016 |
Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Freund's Adjuvant; gamma-Aminobutyric Acid; Glyci | 2017 |
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.
Topics: Alkynes; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; | 2009 |
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
Topics: Analgesics, Opioid; Animals; Bicuculline; Blood Pressure; Capsaicin; Disease Models, Animal; Drug Re | 2009 |
Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons.
Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Chromosomes, Artificial, Bacterial; Constrict | 2009 |
DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls.
Topics: Adult; Amino Acid Sequence; Chronic Disease; DNA Mutational Analysis; Dopamine; Female; Fibromyalgia | 2009 |
T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Calcium Channel Blockers; Calcium | 2009 |
Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats.
Topics: Anesthetics, Local; Animals; Female; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; Injections; Lid | 2010 |
A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity.
Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclopropanes; Glycine; Hyperalgesia; Male; | 2010 |
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; In | 2010 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glut | 2010 |
Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory | 2011 |
Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine.
Topics: Analysis of Variance; Animals; Astrocytes; CD11b Antigen; Citrates; Disease Models, Animal; Enzyme I | 2011 |
Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice.
Topics: Animals; Baclofen; Drug Delivery Systems; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; | 2011 |
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide.
Topics: Alkynes; Animals; Calcium; Cells, Cultured; CHO Cells; Cold Temperature; Cricetinae; Cricetulus; Cys | 2012 |
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato | 2012 |
Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids.
Topics: Animals; Excitatory Amino Acids; Glycine; Hyperalgesia; Injections, Spinal; Male; Pertussis Toxin; R | 2003 |
Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain.
Topics: Animals; Carrageenan; Cold Temperature; Diabetes Mellitus; Disease Models, Animal; Drug Tolerance; E | 2003 |
Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain.
Topics: Animals; Chronic Disease; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Hyperalgesia; Male; Pai | 2003 |
The spinal antinociceptive effect of nocistatin in neuropathic rats is blocked by D-serine.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Animals; Dose-Response Relationship, Drug; Glycine; Hyperalg | 2004 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Dr | 2005 |
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
Topics: Animals; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2005 |
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxyli | 2005 |
Intracellular messengers involved in spontaneous pain, heat hyperalgesia, and mechanical allodynia induced by intrathecal dihydroxyphenylglycine.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hot Temperature; Hyperalgesia; Hyperes | 2006 |
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates | 2007 |
Subarachnoid transplant of a human neuronal cell line attenuates chronic allodynia and hyperalgesia after excitotoxic spinal cord injury in the rat.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Differentiation; Cell Line; Cell Transplantation; | 2007 |
Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain.
Topics: Animals; Biological Availability; Disease Models, Animal; Glycine; Hydroquinones; Hyperalgesia; Infl | 2007 |
Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats.
Topics: Analysis of Variance; Animals; Carrageenan; Dose-Response Relationship, Radiation; gamma-Aminobutyri | 2007 |
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia.
Topics: Animals; Excitatory Amino Acid Antagonists; Gene Silencing; Glycine; Hyperalgesia; Male; Mice; Pain; | 2007 |
Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.
Topics: Action Potentials; Animals; Behavior, Animal; Benzhydryl Compounds; Benzoates; Dose-Response Relatio | 2007 |
Actions of N-arachidonyl-glycine in a rat neuropathic pain model.
Topics: Analgesics; Animals; Arachidonic Acids; Area Under Curve; Camphanes; Disease Models, Animal; Dose-Re | 2008 |
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship, | 2008 |
Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats.
Topics: Animals; Binding Sites; Carrageenan; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonis | 1996 |
Roles of monoaminergic, glycinergic and GABAergic inhibitory systems in the spinal cord in rats with peripheral mononeuropathy.
Topics: Analysis of Variance; Animals; Biogenic Monoamines; Dizocilpine Maleate; Excitatory Amino Acid Antag | 1996 |
Reduction in thermal hyperalgesia by intrathecal administration of glycine and related compounds.
Topics: Analgesia, Epidural; Animals; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Glyci | 1997 |
Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2.
Topics: Animals; Bucladesine; Dibutyryl Cyclic GMP; Glycine; Hyperalgesia; Male; Mice; Narcotic Antagonists; | 1997 |
Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats.
Topics: Animals; Behavior, Animal; Catechols; Glycine; Hyperalgesia; Injections, Spinal; Male; Pain Threshol | 1998 |
Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats.
Topics: Animals; Benzoates; Cold Temperature; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycin | 1998 |
Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.
Topics: Acetamides; Animals; Anticonvulsants; Clorgyline; Glycine; Hyperalgesia; Injections, Intravenous; In | 1998 |
Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain.
Topics: Animals; Glycine; Hyperalgesia; Injections, Spinal; Ligation; Male; Mechanoreceptors; Nervous System | 2000 |
Effects of persistent nociception on periaqueductal gray glycine release.
Topics: Animals; Formaldehyde; Glutamine; Glycine; Hindlimb; Hyperalgesia; Kinetics; Male; Microdialysis; Pe | 2000 |
Group I metabotropic glutamate receptor antagonists block secondary thermal hyperalgesia in rats with knee joint inflammation.
Topics: Animals; Arthritis, Experimental; Benzoates; Carrageenan; Dose-Response Relationship, Drug; Excitato | 2002 |
Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain.
Topics: Animals; Benzoates; Chronic Disease; Excitatory Amino Acid Antagonists; Glycine; Hyperalgesia; Locom | 2002 |
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Tempe | 2002 |
Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve.
Topics: Age Factors; Animals; Aspartic Acid; Causalgia; Down-Regulation; gamma-Aminobutyric Acid; Glutamic A | 2002 |
Hyperalgesia induced by altered glycinergic activity at the spinal cord.
Topics: Animals; Behavior, Animal; Castration; Female; Glycine; Hyperalgesia; Hyperesthesia; Injections, Spi | 1985 |