Page last updated: 2024-10-18

glycine and Allodynia

glycine has been researched along with Allodynia in 67 studies

Research Excerpts

ExcerptRelevanceReference
"Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain."8.31AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023)
" Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia."7.85Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017)
" Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia."7.76Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010)
" The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain."7.75Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009)
"Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats."7.73CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005)
"Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine."7.70Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000)
") strychnine (STR) produces reversible, segmentally localized allodynia in the rat."7.70Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. ( Khandwala, H; Loomis, CW, 1998)
" We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice."7.69Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997)
" We have studied the effects on mechanical nociceptive thresholds in rats with carrageenin-induced paw inflammation of L-687,414, a low efficacy partial agonist which acts as a functional antagonist at the glycine modulatory site of the NMDA receptor and of L-701,324, a structurally novel, highly selective, full antagonist at this site."7.69Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats. ( Hargreaves, RJ; Hill, RG; Laird, JM; Mason, GS; Webb, J, 1996)
"Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery."5.42Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015)
"Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)."5.39Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013)
"Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy."5.35Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia. ( Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL, 2009)
" The analgesic activity of CHF3381 was investigated in the heat-capsaicin human pain model and compared with those of gabapentin."5.12CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model. ( Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O, 2006)
"Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain."4.31AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023)
" Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia."3.85Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017)
" In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema."3.80Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. ( Alfonso, S; Anzini, M; Battilocchio, C; Biava, M; Calderone, V; Colovic, M; Consalvi, S; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Persiani, S; Poce, G; Rossi, A; Sautebin, L; Testai, L, 2014)
"Glycine inhibitory dysfunction provides a useful experimental model for studying the mechanism of dynamic mechanical allodynia, a widespread and intractable symptom of neuropathic pain."3.77Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. ( Dallel, R; Miraucourt, LS; Peirs, C; Voisin, DL, 2011)
" Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia."3.76Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010)
" After recovery, rats received injections of lidocaine, GABA and glycine agonists or antagonists and their effects were assessed on behavioral tests of allodynia and hyperalgesia."3.76Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats. ( Al Amin, H; Atweh, SF; Jabbur, SJ; Saadé, NE; Tchachaghian, S, 2010)
" The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain."3.75Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009)
" This efficient route enabled to scale up the synthesis of an orally bioavailable glycine antagonist showing outstanding in vivo anti-hyperalgesic activity in different animal models of sustained inflammation and chronic neuropathic pain."3.74Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain. ( Alvaro, G; Barnaby, RJ; Bertani, B; Corsi, M; Di Fabio, R; Donati, D; Gentile, G; Giacobbe, S; Pentassuglia, G; Pizzi, DM; Quartaroli, M; Ratti, E; Spada, S; Vitulli, G, 2007)
"In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception."3.74Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007)
"Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats."3.73CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005)
"GABA and glycine are inhibitory neurotransmitters used by many neurons in the spinal dorsal horn, and intrathecal administration of GABA(A) and glycine receptor antagonists produces behavioural signs of allodynia, suggesting that these transmitters have an important role in spinal pain mechanisms."3.72Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain. ( Hughes, DI; Maxwell, DJ; Polgár, E; Puskár, Z; Riddell, JS; Todd, AJ, 2003)
") treatment (twice-daily injections on post-operative (PO) days 0-8) with the metabotropic glutamate receptor (mGluR) compound, (S)-4-carboxyphenylglycine ((S)-4CPG), or the non-competitive N-methyl-D-aspartate (NMDA) antagonist, dizocilipine maleate (MK-801), on mechanical allodynia and cold hyperalgesia associated with chronic constriction injury (CCI) of the sciatic nerve in rats."3.70Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. ( Cahill, CM; Coderre, TJ; Fisher, K; Fundytus, ME, 1998)
") strychnine (STR) produces reversible, segmentally localized allodynia in the rat."3.70Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. ( Khandwala, H; Loomis, CW, 1998)
"Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine."3.70Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000)
" We have studied the effects on mechanical nociceptive thresholds in rats with carrageenin-induced paw inflammation of L-687,414, a low efficacy partial agonist which acts as a functional antagonist at the glycine modulatory site of the NMDA receptor and of L-701,324, a structurally novel, highly selective, full antagonist at this site."3.69Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats. ( Hargreaves, RJ; Hill, RG; Laird, JM; Mason, GS; Webb, J, 1996)
" We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice."3.69Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997)
"The PTX-induced thermal hyperalgesia peaked between day 2 and 4, but no cold allodynia is observed; i."2.42Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome. ( Chang, YC; Wen, ZH; Wong, CS, 2003)
"However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment."1.62Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model. ( Al-Khrasani, M; Balogh, M; Barsi, S; Benyhe, S; Galambos, AR; Harsing, LG; Karádi, DÁ; Király, K; Köles, L; Lakatos, PP; Mohammadzadeh, A; Riba, P; Szökő, É; Tábi, T; Zádor, F; Zádori, ZS, 2021)
"MCS reversed the hyperalgesia induced by peripheral neuropathy in the rats with chronic sciatic nerve constriction and induced a significant increase in the glycine and GABA levels in the PAG in comparison with the naive and sham-treated rats."1.51Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain. ( Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL, 2019)
"Treatment with SR9009 also blocked tumor necrosis factor-induced IL-1β mRNA, IL-6 mRNA and MMP-9 mRNA."1.51Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice. ( Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF, 2019)
"Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome."1.48Endogenous H ( Bo, Q; Cui, J; Du, J; Shi, B; Wang, W; Wang, Y; Yu, X; Zhao, H; Zhu, K; Zhu, Y, 2018)
"Neuropathic pain is an integral component of several chronic pain conditions and poses a major health problem worldwide."1.46Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component. ( Bali, KK; Kuner, R, 2017)
"Mechanical hyperalgesia induced by (R,S)-3,5-dihydroxyphenylglycine (DHPG), an mGlu1/5 agonist, in the masseter muscle was attenuated by AMG9810, a specific TRPV1 antagonist."1.42Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat. ( Chung, MK; Joseph, J; Lee, J; Ro, JY; Saloman, J, 2015)
"Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery."1.42Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015)
"Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)."1.39Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013)
"Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor."1.36The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. ( Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS, 2010)
"In vivo testing in a rodent model of neuropathic pain indicated one amino acid significantly and dose-dependently decreased mechanical allodynia."1.36A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. ( Abell, AD; Avery, TD; Bräuner-Osborne, H; Hutchinson, MR; Irvine, RJ; Kvist, T; Mathiesen, JM; Nielsen, B; Pedersen, DS; Stanley, NJ; Taylor, DK; Tiekink, ER, 2010)
"Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy."1.35Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia. ( Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL, 2009)
"The NAGly induced anti-allodynia was dose dependent and, unlike HU-210, was unaffected by the cannabinoid CB(1) and CB(2) receptor antagonists, AM251 and SR144528 (30 nmol)."1.35Actions of N-arachidonyl-glycine in a rat neuropathic pain model. ( Mitchell, VA; Vaughan, CW; Vuong, LA, 2008)
"Morphine tolerance was induced in mice by implanting a 75 mg morphine pellet and assessing morphine-induced antinociception 72-h later."1.35mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo. ( Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL, 2008)
"TENS reduces hyperalgesia through activation of receptor-mediated pathways at the level of the spinal cord, and supraspinally."1.34Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats. ( Lisi, TL; Maeda, Y; Sluka, KA; Vance, CG, 2007)
" Unlike morphine, CHF3381 chronic administration was not accompanied by the development of tolerance in the formalin test."1.32Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. ( Barbieri, M; Bassani, F; Bergamaschi, M; Bolzoni, PT; Chamiot-Clerc, P; Maiorino, M; Pietra, C; Rondelli, I; Simonato, M; Villetti, G, 2003)
"Pertussis toxin injection induced thermal hyperalgesia which peaked between day 2 and 4; no cold allodynia was observed."1.32Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids. ( Chang, YC; Chen, JY; Hsing, CH; Wang, JJ; Wen, ZH; Wong, CS; Yang, LC, 2003)
"Glycine is a candidate nociception inhibitory transmitter in specific brain regions, like for example the spinal cord, the thalamic nuclei and the periaqueductal gray matter."1.31Effects of persistent nociception on periaqueductal gray glycine release. ( Berrino, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Trabace, L, 2000)
"Skin hyperalgesia persisted for at least 30 minutes in both strychnine and glycine treated rats."1.27Hyperalgesia induced by altered glycinergic activity at the spinal cord. ( Beyer, C; Komisaruk, BR; Roberts, LA, 1985)

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.49)18.7374
1990's7 (10.45)18.2507
2000's30 (44.78)29.6817
2010's26 (38.81)24.3611
2020's3 (4.48)2.80

Authors

AuthorsStudies
Wang, J1
Ding, Z1
Xu, W1
He, L1
Huang, J2
Zhang, C1
Guo, Q1
Zou, W1
Wang, HC1
Cheng, KI1
Tseng, KY1
Kwan, AL1
Chang, LL1
Garattini, EG1
Santos, BM1
Ferrari, DP1
Capel, CP1
Francescato, HDC1
Coimbra, TM1
Leite-Panissi, CRA1
Branco, LGS1
Nascimento, GC1
Mohammadzadeh, A2
Lakatos, PP1
Balogh, M2
Zádor, F1
Karádi, DÁ1
Zádori, ZS2
Király, K2
Galambos, AR1
Barsi, S2
Riba, P1
Benyhe, S1
Köles, L2
Tábi, T1
Szökő, É1
Harsing, LG2
Al-Khrasani, M2
Honda, K2
Shinoda, M2
Kondo, M1
Shimizu, K1
Yonemoto, H1
Otsuki, K1
Akasaka, R1
Furukawa, A2
Iwata, K2
Bali, KK1
Kuner, R1
Wang, W1
Bo, Q1
Du, J1
Yu, X1
Zhu, K1
Cui, J1
Zhao, H1
Wang, Y2
Shi, B1
Zhu, Y1
Shi, Y1
Chen, Y2
de Andrade, EM1
Martinez, RCR1
Pagano, RL1
Lopes, PSS1
Auada, AVV1
Gouveia, FV1
Antunes, GF1
Assis, DV1
Lebrun, I1
Fonoff, ET1
Morioka, N1
Kodama, K1
Tomori, M1
Yoshikawa, K1
Saeki, M1
Nakamura, Y1
Zhang, FF1
Hisaoka-Nakashima, K1
Nakata, Y1
Hajnal, B1
Velasco-Xolalpa, ME1
Barragán-Iglesias, P1
Roa-Coria, JE1
Godínez-Chaparro, B1
Flores-Murrieta, FJ1
Torres-López, JE1
Araiza-Saldaña, CI1
Navarrete, A1
Rocha-González, HI1
Biava, M1
Battilocchio, C1
Poce, G1
Alfonso, S1
Consalvi, S1
Di Capua, A1
Calderone, V1
Martelli, A1
Testai, L1
Sautebin, L1
Rossi, A1
Ghelardini, C1
Di Cesare Mannelli, L1
Giordani, A1
Persiani, S1
Colovic, M1
Dovizio, M1
Patrignani, P1
Anzini, M1
Chirila, AM1
Brown, TE1
Bishop, RA1
Bellono, NW1
Pucci, FG1
Kauer, JA1
Chung, MK1
Lee, J1
Joseph, J1
Saloman, J1
Ro, JY1
Foster, E1
Wildner, H1
Tudeau, L1
Haueter, S1
Ralvenius, WT1
Jegen, M1
Johannssen, H1
Hösli, L1
Haenraets, K1
Ghanem, A1
Conzelmann, KK1
Bösl, M1
Zeilhofer, HU3
Ohashi, N1
Sasaki, M1
Ohashi, M1
Kamiya, Y1
Baba, H1
Kohno, T1
Watson, CJ1
Govea, RM1
Zhou, S1
Carlton, SM1
Takazawa, T1
Choudhury, P1
Tong, CK1
Conway, CM1
Scherrer, G1
Flood, PD1
Mukai, J1
MacDermott, AB1
Nishimura, S1
Fukushima, O1
Ishikura, H1
Takahashi, T1
Matsunami, M1
Tsujiuchi, T1
Sekiguchi, F1
Naruse, M1
Kamanaka, Y1
Kawabata, A1
Miraucourt, LS2
Moisset, X1
Dallel, R2
Voisin, DL2
Hermanns, H1
Muth-Selbach, U2
Lipfert, P2
Braun, S1
Werdehausen, R1
Bauer, I1
Potvin, S1
Larouche, A1
Normand, E1
de Souza, JB1
Gaumond, I1
Grignon, S1
Marchand, S1
Barbara, G1
Alloui, A1
Nargeot, J1
Lory, P1
Eschalier, A1
Bourinet, E1
Chemin, J1
Saadé, NE1
Al Amin, H1
Tchachaghian, S1
Jabbur, SJ1
Atweh, SF1
Stanley, NJ1
Hutchinson, MR1
Kvist, T1
Nielsen, B1
Mathiesen, JM1
Bräuner-Osborne, H1
Avery, TD1
Tiekink, ER1
Pedersen, DS1
Irvine, RJ1
Abell, AD1
Taylor, DK1
Lee, IO2
Lim, ES2
Rondon, ES1
Vieira, AS1
Valadão, CA1
Parada, CA1
Kodama, D1
Ono, H1
Tanabe, M1
Peirs, C1
Son, JK1
Kim, YS1
Andersson, DA1
Gentry, C1
Bevan, S1
Liu, MG1
Matsuura, S1
Suzuki, I1
Shibuta, K1
Tamagawa, T1
Katagiri, A1
Kiyomoto, M1
Ohara, K1
Urata, K1
Wen, ZH2
Yang, LC1
Wang, JJ1
Chang, YC2
Hsing, CH1
Chen, JY1
Wong, CS2
Villetti, G2
Bergamaschi, M2
Bassani, F2
Bolzoni, PT1
Maiorino, M1
Pietra, C1
Rondelli, I1
Chamiot-Clerc, P1
Simonato, M1
Barbieri, M1
Polgár, E1
Hughes, DI1
Riddell, JS1
Maxwell, DJ1
Puskár, Z1
Todd, AJ1
Dybek, E1
Kollosche, K1
Stegmann, JU1
Holthusen, H1
Shimoyama, N1
Shimoyama, M1
Davis, AM1
Monaghan, DT1
Inturrisi, CE1
Reinold, H1
Ahmadi, S1
Depner, UB1
Layh, B1
Heindl, C1
Hamza, M1
Pahl, A1
Brune, K1
Narumiya, S1
Müller, U1
Price, TJ1
Cervero, F1
de Koninck, Y1
Tonino Bolzoni, P1
Mathiesen, O1
Imbimbo, BP1
Hilsted, KL1
Fabbri, L1
Dahl, JB1
Ambrosini, SS1
Coderre, TJ3
Marabese, I3
de Novellis, V2
Palazzo, E3
Scafuro, MA1
Vita, D2
Rossi, F4
Maione, S3
Eaton, MJ1
Wolfe, SQ1
Martinez, M1
Hernandez, M1
Furst, C1
Frydel, BR1
Gómez-Marín, O1
Di Fabio, R1
Alvaro, G1
Bertani, B1
Donati, D1
Pizzi, DM1
Gentile, G1
Pentassuglia, G1
Giacobbe, S1
Spada, S1
Ratti, E1
Corsi, M1
Quartaroli, M1
Barnaby, RJ1
Vitulli, G1
Maeda, Y1
Lisi, TL1
Vance, CG1
Sluka, KA1
Gabra, BH2
Kessler, FK1
Ritter, JK1
Dewey, WL2
Smith, FL2
Starowicz, K1
Cristino, L1
Gatta, L1
Guida, F1
Di Marzo, V1
Vuong, LA1
Mitchell, VA1
Vaughan, CW1
Navarro, HA1
Carroll, FI1
Laird, JM1
Mason, GS1
Webb, J1
Hill, RG1
Hargreaves, RJ1
Satoh, O1
Omote, K1
Simpson, RK2
Gondo, M1
Robertson, CS1
Goodman, JC1
Minami, T1
Okuda-Ashitaka, E1
Nishizawa, M1
Mori, H1
Ito, S1
Fisher, K2
Fundytus, ME1
Cahill, CM1
Khandwala, H1
Loomis, CW1
Huang, W1
Berrino, L1
Trabace, L1
Zhang, L1
Lu, Y1
Westlund, KN1
Mills, CD1
Johnson, KM1
Hulsebosch, CE1
García-Martinez, C1
Humet, M1
Planells-Cases, R1
Gomis, A1
Caprini, M1
Viana, F1
De La Pena, E1
Sanchez-Baeza, F1
Carbonell, T1
De Felipe, C1
Pérez-Paya, E1
Belmonte, C1
Messeguer, A1
Ferrer-Montiel, A1
Somers, DL1
Clemente, FR1
Beyer, C1
Roberts, LA1
Komisaruk, BR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815]Phase 1/Phase 2272 participants (Actual)Interventional2017-02-13Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for glycine and Allodynia

ArticleYear
Glycine transporter inhibitors: A new avenue for managing neuropathic pain.
    Brain research bulletin, 2019, Volume: 152

    Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Hyperalgesia; Neuralgia; Neuro

2019
Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome.
    Acta anaesthesiologica Sinica, 2003, Volume: 41, Issue:4

    Topics: Animals; Disease Models, Animal; Excitatory Amino Acids; Glycine; Hyperalgesia; Injections, Spinal;

2003
Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia.
    Current topics in medicinal chemistry, 2005, Volume: 5, Issue:6

    Topics: Analgesics; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; K Cl- Cotransporters; Pain; Posterior Ho

2005

Trials

1 trial available for glycine and Allodynia

ArticleYear
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
    The journal of pain, 2006, Volume: 7, Issue:8

    Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind

2006

Other Studies

63 other studies available for glycine and Allodynia

ArticleYear
Botulinum toxin type A counteracts neuropathic pain by countering the increase of GlyT2 expression in the spinal cord of CCI rats.
    Brain research, 2022, 12-01, Volume: 1796

    Topics: Analgesics; Animals; Botulinum Toxins, Type A; Crush Injuries; Glycine; Glycine Plasma Membrane Tran

2022
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats.
    Molecular medicine (Cambridge, Mass.), 2023, 02-15, Volume: 29, Issue:1

    Topics: Animals; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Glycine; Human

2023
Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model.
    Nitric oxide : biology and chemistry, 2019, 12-01, Volume: 93

    Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Hyperalge

2019
Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model.
    International journal of molecular sciences, 2021, Mar-01, Volume: 22, Issue:5

    Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Hyperalgesia; Male; Motor Activity; Ne

2021
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
    Pain, 2017, Volume: 158, Issue:9

    Topics: Acetanilides; Animals; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Glutamic Acid;

2017
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
    Pain, 2017, Volume: 158, Issue:11

    Topics: Analgesics; Animals; Cancer Pain; Chronic Pain; Cyclic S-Oxides; Disease Models, Animal; Female; Gly

2017
Endogenous H
    American journal of physiology. Renal physiology, 2018, 06-01, Volume: 314, Issue:6

    Topics: Alkynes; Aminooxyacetic Acid; Analgesics; Animals; Cell Line; Cystathionine gamma-Lyase; Cystitis, I

2018
Kir2.1 Channel Regulation of Glycinergic Transmission Selectively Contributes to Dynamic Mechanical Allodynia in a Mouse Model of Spared Nerve Injury.
    Neuroscience bulletin, 2019, Volume: 35, Issue:2

    Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hyperalgesia; Imidazoles; Inhibitory Postsyna

2019
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.
    Journal of neurosurgery, 2019, 01-04, Volume: 132, Issue:1

    Topics: Analgesia; Animals; Bicuculline; Deep Brain Stimulation; Efferent Pathways; GABA Antagonists; gamma-

2019
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice.
    Brain, behavior, and immunity, 2019, Volume: 78

    Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Infl

2019
Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats.
    Neuroscience, 2013, Oct-10, Volume: 250

    Topics: Algorithms; Alkynes; Animals; Blood Glucose; Cystathionine gamma-Lyase; Cysteine; Data Interpretatio

2013
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
    Bioorganic & medicinal chemistry, 2014, Jan-15, Volume: 22, Issue:2

    Topics: Acetic Acid; Amides; Animals; Carrageenan; Cell Line; Constriction, Pathologic; Cyclooxygenase 2; Cy

2014
Long-term potentiation of glycinergic synapses triggered by interleukin 1β.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jun-03, Volume: 111, Issue:22

    Topics: Animals; Behavior, Animal; GABAergic Neurons; Glycine; Hyperalgesia; Interleukin-1beta; Interneurons

2014
Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat.
    The journal of pain, 2015, Volume: 16, Issue:1

    Topics: A Kinase Anchor Proteins; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Disease Mo

2015
Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.
    Neuron, 2015, Mar-18, Volume: 85, Issue:6

    Topics: Animals; Disease Models, Animal; Glycine; Hyperalgesia; Mice; Mice, Transgenic; Nerve Net; Neurons;

2015
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn.
    Scientific reports, 2015, Aug-21, Volume: 5

    Topics: Animals; Behavior, Animal; Biomarkers; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases

2015
Insular balance of glutamatergic and GABAergic signaling modulates pain processing.
    Pain, 2016, Volume: 157, Issue:10

    Topics: Analysis of Variance; Animals; Avoidance Learning; Cerebral Cortex; Disease Models, Animal; Excitato

2016
Group III mGluR8 negatively modulates TRPA1.
    Neuroscience, 2016, Oct-15, Volume: 334

    Topics: Animals; Benzoates; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Excitatory Amino

2016
Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017, 03-01, Volume: 37, Issue:9

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Freund's Adjuvant; gamma-Aminobutyric Acid; Glyci

2017
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.
    Gut, 2009, Volume: 58, Issue:6

    Topics: Alkynes; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin;

2009
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Feb-25, Volume: 29, Issue:8

    Topics: Analgesics, Opioid; Animals; Bicuculline; Blood Pressure; Capsaicin; Disease Models, Animal; Drug Re

2009
Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons.
    Neuroscience, 2009, Mar-31, Volume: 159, Issue:3

    Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Chromosomes, Artificial, Bacterial; Constrict

2009
DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls.
    The journal of pain, 2009, Volume: 10, Issue:9

    Topics: Adult; Amino Acid Sequence; Chronic Disease; DNA Mutational Analysis; Dopamine; Female; Fibromyalgia

2009
T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Oct-21, Volume: 29, Issue:42

    Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Calcium Channel Blockers; Calcium

2009
Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats.
    Pain, 2010, Volume: 149, Issue:1

    Topics: Anesthetics, Local; Animals; Female; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; Injections; Lid

2010
A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity.
    Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

    Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclopropanes; Glycine; Hyperalgesia; Male;

2010
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:8

    Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; In

2010
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
    European journal of pharmacology, 2010, Nov-25, Volume: 647, Issue:1-3

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glut

2010
Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury.
    Pain, 2011, Volume: 152, Issue:4

    Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory

2011
Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine.
    Pain, 2011, Volume: 152, Issue:6

    Topics: Analysis of Variance; Animals; Astrocytes; CD11b Antigen; Citrates; Disease Models, Animal; Enzyme I

2011
Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice.
    Journal of Korean medical science, 2011, Volume: 26, Issue:10

    Topics: Animals; Baclofen; Drug Delivery Systems; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid;

2011
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Alkynes; Animals; Calcium; Cells, Cultured; CHO Cells; Cold Temperature; Cricetinae; Cricetulus; Cys

2012
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
    Journal of neuroinflammation, 2012, Nov-27, Volume: 9

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato

2012
Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids.
    Neuroscience, 2003, Volume: 116, Issue:3

    Topics: Animals; Excitatory Amino Acids; Glycine; Hyperalgesia; Injections, Spinal; Male; Pertussis Toxin; R

2003
Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2

    Topics: Animals; Carrageenan; Cold Temperature; Diabetes Mellitus; Disease Models, Animal; Drug Tolerance; E

2003
Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Animals; Chronic Disease; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Hyperalgesia; Male; Pai

2003
The spinal antinociceptive effect of nocistatin in neuropathic rats is blocked by D-serine.
    Anesthesiology, 2004, Volume: 101, Issue:3

    Topics: Analgesics, Opioid; Anesthesia, Spinal; Animals; Dose-Response Relationship, Drug; Glycine; Hyperalg

2004
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Dr

2005
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
    The Journal of clinical investigation, 2005, Volume: 115, Issue:3

    Topics: Animals; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

2005
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
    European journal of pharmacology, 2005, Sep-20, Volume: 519, Issue:3

    Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxyli

2005
Intracellular messengers involved in spontaneous pain, heat hyperalgesia, and mechanical allodynia induced by intrathecal dihydroxyphenylglycine.
    Neuroscience letters, 2006, Dec-06, Volume: 409, Issue:3

    Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hot Temperature; Hyperalgesia; Hyperes

2006
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates

2007
Subarachnoid transplant of a human neuronal cell line attenuates chronic allodynia and hyperalgesia after excitotoxic spinal cord injury in the rat.
    The journal of pain, 2007, Volume: 8, Issue:1

    Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Differentiation; Cell Line; Cell Transplantation;

2007
Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain.
    Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5

    Topics: Animals; Biological Availability; Disease Models, Animal; Glycine; Hydroquinones; Hyperalgesia; Infl

2007
Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats.
    Brain research, 2007, Mar-09, Volume: 1136, Issue:1

    Topics: Analysis of Variance; Animals; Carrageenan; Dose-Response Relationship, Radiation; gamma-Aminobutyri

2007
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: Animals; Excitatory Amino Acid Antagonists; Gene Silencing; Glycine; Hyperalgesia; Male; Mice; Pain;

2007
Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.
    Journal of neurophysiology, 2007, Volume: 98, Issue:1

    Topics: Action Potentials; Animals; Behavior, Animal; Benzhydryl Compounds; Benzoates; Dose-Response Relatio

2007
Actions of N-arachidonyl-glycine in a rat neuropathic pain model.
    Neuropharmacology, 2008, Volume: 54, Issue:1

    Topics: Analgesics; Animals; Arachidonic Acids; Area Under Curve; Camphanes; Disease Models, Animal; Dose-Re

2008
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
    Brain research, 2008, Jan-02, Volume: 1187

    Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship,

2008
Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats.
    British journal of pharmacology, 1996, Volume: 117, Issue:7

    Topics: Animals; Binding Sites; Carrageenan; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonis

1996
Roles of monoaminergic, glycinergic and GABAergic inhibitory systems in the spinal cord in rats with peripheral mononeuropathy.
    Brain research, 1996, Jul-22, Volume: 728, Issue:1

    Topics: Analysis of Variance; Animals; Biogenic Monoamines; Dizocilpine Maleate; Excitatory Amino Acid Antag

1996
Reduction in thermal hyperalgesia by intrathecal administration of glycine and related compounds.
    Neurochemical research, 1997, Volume: 22, Issue:1

    Topics: Analgesia, Epidural; Animals; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Glyci

1997
Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2.
    British journal of pharmacology, 1997, Volume: 122, Issue:4

    Topics: Animals; Bucladesine; Dibutyryl Cyclic GMP; Glycine; Hyperalgesia; Male; Mice; Narcotic Antagonists;

1997
Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats.
    Neuroreport, 1998, Apr-20, Volume: 9, Issue:6

    Topics: Animals; Behavior, Animal; Catechols; Glycine; Hyperalgesia; Injections, Spinal; Male; Pain Threshol

1998
Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats.
    Pain, 1998, Volume: 77, Issue:1

    Topics: Animals; Benzoates; Cold Temperature; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycin

1998
Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.
    Pain, 1998, Volume: 77, Issue:1

    Topics: Acetamides; Animals; Anticonvulsants; Clorgyline; Glycine; Hyperalgesia; Injections, Intravenous; In

1998
Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain.
    Neurological research, 2000, Volume: 22, Issue:2

    Topics: Animals; Glycine; Hyperalgesia; Injections, Spinal; Ligation; Male; Mechanoreceptors; Nervous System

2000
Effects of persistent nociception on periaqueductal gray glycine release.
    Neuroscience, 2000, Volume: 97, Issue:2

    Topics: Animals; Formaldehyde; Glutamine; Glycine; Hindlimb; Hyperalgesia; Kinetics; Male; Microdialysis; Pe

2000
Group I metabotropic glutamate receptor antagonists block secondary thermal hyperalgesia in rats with knee joint inflammation.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Animals; Arthritis, Experimental; Benzoates; Carrageenan; Dose-Response Relationship, Drug; Excitato

2002
Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain.
    Journal of neurotrauma, 2002, Volume: 19, Issue:1

    Topics: Animals; Benzoates; Chronic Disease; Excitatory Amino Acid Antagonists; Glycine; Hyperalgesia; Locom

2002
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-19, Volume: 99, Issue:4

    Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Tempe

2002
Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve.
    Neuroscience letters, 2002, May-03, Volume: 323, Issue:3

    Topics: Age Factors; Animals; Aspartic Acid; Causalgia; Down-Regulation; gamma-Aminobutyric Acid; Glutamic A

2002
Hyperalgesia induced by altered glycinergic activity at the spinal cord.
    Life sciences, 1985, Sep-02, Volume: 37, Issue:9

    Topics: Animals; Behavior, Animal; Castration; Female; Glycine; Hyperalgesia; Hyperesthesia; Injections, Spi

1985