Page last updated: 2024-10-19

nitrates and Allodynia

nitrates has been researched along with Allodynia in 18 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Research Excerpts

ExcerptRelevanceReference
" In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema."3.80Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. ( Alfonso, S; Anzini, M; Battilocchio, C; Biava, M; Calderone, V; Colovic, M; Consalvi, S; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Persiani, S; Poce, G; Rossi, A; Sautebin, L; Testai, L, 2014)
"Background Periodontitis is an inflammatory disease accompanied by alveolar bone loss and progressive inflammation without pain."1.46CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice. ( Honda, K; Iwata, K; Kamio, N; Nagashima, H; Sato, S; Shinoda, M; Sugano, N; Suzuki, T; Watanabe, M, 2017)
" We determined the antiallodynic response of NCX1404 after acute or after 7, 14, and 21 days of repeated daily oral dosing in mice with streptozotocin (STZ)-induced painful diabetic neuropathy (PDN)."1.43Repeated Dosing with NCX1404, a Nitric Oxide-Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful Diabetic Neuropathy. ( Almirante, N; Bastia, E; Brambilla, S; Impagnatiello, F; Ravani, A; Storoni, L; Targa, M; Varani, K; Vincenzi, F, 2016)
"Using a carrageenan-induced thermal hyperalgesia model, we evaluated the effect of C-PC on nociception by measuring paw withdrawal latency."1.35Antiinflammatory and antihyperalgesic activity of C-phycocyanin. ( Cheng, SN; Chou, TC; Kuo, YL; Shih, CM; Wong, CS, 2009)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.11)18.2507
2000's10 (55.56)29.6817
2010's5 (27.78)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Oghbaei, H1
Alipour, MR1
Mohaddes, G1
Hamidian, GR1
Keyhanmanesh, R1
Micheli, L1
Di Cesare Mannelli, L2
Mattoli, L1
Tamimi, S1
Flamini, E1
Garetto, S1
Lucci, J1
Giovagnoni, E1
Cinci, L1
D'Ambrosio, M1
Luceri, C1
Ghelardini, C2
Nagashima, H1
Shinoda, M1
Honda, K1
Kamio, N1
Watanabe, M1
Suzuki, T1
Sugano, N1
Sato, S1
Iwata, K1
Biava, M1
Battilocchio, C1
Poce, G1
Alfonso, S1
Consalvi, S1
Di Capua, A1
Calderone, V1
Martelli, A1
Testai, L1
Sautebin, L1
Rossi, A1
Giordani, A1
Persiani, S1
Colovic, M1
Dovizio, M1
Patrignani, P1
Anzini, M1
Varani, K1
Vincenzi, F1
Targa, M1
Ravani, A1
Bastia, E1
Storoni, L1
Brambilla, S1
Almirante, N1
Impagnatiello, F1
Achem, SR1
Shih, CM1
Cheng, SN1
Wong, CS1
Kuo, YL1
Chou, TC1
Garrido-Suárez, BB1
Garrido, G1
Márquez, L1
Martínez, I1
Hernández, I1
Merino, N1
Luque, Y1
Delgado, R1
Bosch, F1
Santana, DG1
Santos, CA1
Santos, AD1
Nogueira, PC1
Thomazzi, SM1
Estevam, CS1
Antoniolli, AR1
Camargo, EA1
Gaitán, G1
Ahuir, FJ1
Herrero, JF2
Naik, AK1
Tandan, SK1
Kumar, D1
Dudhgaonkar, SP1
Costa, B1
Siniscalco, D1
Trovato, AE1
Comelli, F1
Sotgiu, ML1
Colleoni, M1
Maione, S1
Rossi, F1
Giagnoni, G1
Alfonso Romero-Sandoval, E1
Molina, C1
Menéndez, L1
Juárez, L1
García, V1
Hidalgo, A1
Baamonde, A1
Wu, J2
Lin, Q2
McAdoo, DJ1
Willis, WD2
Palecek, J1
Palecková, V1
Peng, YB1
Cui, M1
Liu, T1
Knight, KR1
Tracey, DJ1
Omote, K1
Hazama, K1
Kawamata, T1
Kawamata, M1
Nakayaka, Y1
Toriyabe, M1
Namiki, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Randomized, Double-blind, Parallel, Placebo-controlled, Multi-center Study to Investigate the Efficacy and Safety of Apomivir® in Relieving Influenza Symptoms[NCT01677689]Phase 2196 participants (Anticipated)Interventional2018-09-01Not yet recruiting
A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838]Phase 240 participants (Anticipated)Interventional2009-05-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nitrates and Allodynia

ArticleYear
Treatment of non-cardiac chest pain.
    Disease-a-month : DM, 2008, Volume: 54, Issue:9

    Topics: Anti-Ulcer Agents; Botulinum Toxins, Type A; Calcium Channel Blockers; Chest Pain; Diltiazem; Enzyme

2008

Other Studies

17 other studies available for nitrates and Allodynia

ArticleYear
Evaluation of ameliorative effect of sodium nitrate in experimental model of streptozotocin-induced diabetic neuropathy in male rats.
    Endocrine regulations, 2019, Jan-01, Volume: 53, Issue:1

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Evaluation, Preclinical; Hyper

2019
Intra-Articular Route for the System of Molecules 14G1862 from
    Nutrients, 2020, May-31, Volume: 12, Issue:6

    Topics: Analgesics; Animals; Arthritis, Experimental; Cell Survival; Centella; Disease Models, Animal; Hyper

2020
CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice.
    Molecular pain, 2017, Volume: 13

    Topics: Animals; Antibodies; Antigens, Differentiation; Bacteroidaceae Infections; Disease Models, Animal; H

2017
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
    Bioorganic & medicinal chemistry, 2014, Jan-15, Volume: 22, Issue:2

    Topics: Acetic Acid; Amides; Animals; Carrageenan; Cell Line; Constriction, Pathologic; Cyclooxygenase 2; Cy

2014
Repeated Dosing with NCX1404, a Nitric Oxide-Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful Diabetic Neuropathy.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:2

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relati

2016
Antiinflammatory and antihyperalgesic activity of C-phycocyanin.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Dinoprostone; Disease

2009
Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation: role of nitric oxide.
    Brain research bulletin, 2009, Aug-14, Volume: 79, Issue:6

    Topics: Animals; Carrageenan; Electroacupuncture; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hot

2009
Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.
    Journal of ethnopharmacology, 2012, Jul-13, Volume: 142, Issue:2

    Topics: Abdominal Pain; Acute Disease; Amylases; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Caes

2012
Enhancement of fentanyl antinociception by subeffective doses of nitroparacetamol (NCX-701) in acute nociception and in carrageenan-induced monoarthritis.
    Life sciences, 2005, May-20, Volume: 77, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-

2005
Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: Animals; Arginine; Behavior, Animal; Cold Temperature; Constriction, Pathologic; Disease Models, Ani

2006
AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain.
    British journal of pharmacology, 2006, Volume: 148, Issue:7

    Topics: Analgesics; Animals; Apoptosis; Arachidonic Acids; bcl-2-Associated X Protein; Behavior, Animal; Blo

2006
Enhancement of the analgesic activity of paracetamol and nitroparacetamol by the oral administration of all-trans retinoic acid.
    Neuropharmacology, 2006, Volume: 51, Issue:4

    Topics: Acetaminophen; Administration, Oral; Analgesics; Analysis of Variance; Animals; Antineoplastic Agent

2006
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Ad

2007
Nitric oxide contributes to central sensitization following intradermal injection of capsaicin.
    Neuroreport, 1998, Mar-09, Volume: 9, Issue:4

    Topics: Analysis of Variance; Animals; Capsaicin; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; NG-

1998
Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons.
    Journal of neurophysiology, 1999, Volume: 81, Issue:3

    Topics: Animals; Capsaicin; Enzyme Inhibitors; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis;

1999
Hyperalgesia due to nerve injury-role of peroxynitrite.
    Neuroscience, 2000, Volume: 97, Issue:1

    Topics: Animals; Hyperalgesia; Hyperthermia, Induced; Immunohistochemistry; Male; Nerve Compression Syndrome

2000
Peripheral nitric oxide in carrageenan-induced inflammation.
    Brain research, 2001, Sep-07, Volume: 912, Issue:2

    Topics: Animals; Carrageenan; Drug Interactions; Edema; Enzyme Inhibitors; Guanidines; Hyperalgesia; Inflamm

2001