Page last updated: 2024-10-30

loperamide and Allodynia

loperamide has been researched along with Allodynia in 13 studies

Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

Research Excerpts

ExcerptRelevanceReference
"Previous reports have shown that systemic administration of morphine can prevent the thermal hyperalgesia induced by the development of an osteosarcoma in C3H/HeJ mice after the implantation of NCTC 2472 cells."3.72Peripheral opioids act as analgesics in bone cancer pain in mice. ( Baamonde, A; García, E; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2003)
"The present results suggest that thermal hyperalgesia in experimental neuropathic pain can be reduced through activation of peripheral delta-opioid receptors."1.34Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. ( Hruby, VJ; Porreca, F; Shinoda, K, 2007)
"Loperamide was more potent in male than female arthritic rats at producing antihyperalgesia."1.33Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats. ( Cook, CD; Nickerson, MD, 2005)
"Treatment with loperamide on the normal paw produced short-lasting hypoalgesia, but the effect was not reversible with naloxone."1.30Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide. ( Nozaki-Taguchi, N; Yaksh, TL, 1999)
"Loperamide has potential therapeutic use as a peripherally selective opiate antihyperalgesic agent that lacks many of the side effects generally associated with administration of centrally acting opiates."1.30Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. ( Burgos, LC; Cassel, JA; Daubert, JD; DeHaven, RN; DeHaven-Hudkins, DL; Mansson, E; Nagasaka, H; Yaksh, T; Yu, G, 1999)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (15.38)18.2507
2000's6 (46.15)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
He, SQ1
Yang, F2
Perez, FM1
Xu, Q1
Shechter, R1
Cheong, YK1
Carteret, AF2
Dong, X2
Sweitzer, SM1
Raja, SN3
Guan, Y3
Kumar, R1
Reeta, KH1
Ray, SB1
Chung, C1
McKelvy, AD1
Ringkamp, M2
Hartke, TV2
Hama, A1
Tal, M1
Wooten, M1
McKelvy, A1
Turnquist, BP1
Meyer, RA1
Menéndez, L3
Lastra, A1
Hidalgo, A3
Meana, A1
García, E1
Baamonde, A3
Cook, CD1
Nickerson, MD1
Shinoda, K1
Hruby, VJ1
Porreca, F1
Juárez, L2
García, V1
Curto-Reyes, V1
García-Pérez, E1
Fresno, MF1
Nozaki-Taguchi, N2
Yaksh, TL2
DeHaven-Hudkins, DL1
Burgos, LC1
Cassel, JA1
Daubert, JD1
DeHaven, RN1
Mansson, E1
Nagasaka, H1
Yu, G1
Yaksh, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Topical Loperamide Gel for Pain Reduction During Repeat Finger Lancing: A Randomized Double Blind Trial[NCT02711891]Early Phase 134 participants (Actual)Interventional2015-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

13 other studies available for loperamide and Allodynia

ArticleYear
Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats.
    Pain, 2013, Volume: 154, Issue:11

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Calcium; Dizocilpine Maleate; Dose

2013
Chronic spinal infusion of loperamide alleviates postsurgical pain in rats.
    Indian journal of experimental biology, 2014, Volume: 52, Issue:4

    Topics: Analgesics; Animals; Hyperalgesia; Infusions, Spinal; Loperamide; Male; Pain, Postoperative; Rats; R

2014
Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury.
    European journal of pain (London, England), 2012, Volume: 16, Issue:7

    Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hot Temperature;

2012
The challenge of understanding peripherally mediated antinociception: commentary on a paper by Chung et al. (2012, this issue).
    European journal of pain (London, England), 2012, Volume: 16, Issue:7

    Topics: Analgesia; Analgesics; Animals; Hyperalgesia; Loperamide; Male; Peripheral Nerve Injuries; Spinal Ne

2012
Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Analgesics, Opioid; Animals; Electrophysiological Phenomena; Hyperalgesia; Injections; Loperamide; M

2012
Peripheral opioids act as analgesics in bone cancer pain in mice.
    Neuroreport, 2003, May-06, Volume: 14, Issue:6

    Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cell Culture Techniques; Hyperalgesia; Loperamide; Mice

2003
Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Body Weight; Butorphanol; Dose-Response Relati

2005
Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors.
    Neuroscience letters, 2007, Jan-10, Volume: 411, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dru

2007
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Ad

2007
Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice.
    Cellular and molecular neurobiology, 2008, Volume: 28, Issue:7

    Topics: Analgesics, Opioid; Animals; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cyclic GMP; Disease M

2008
Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide.
    Anesthesiology, 1999, Volume: 90, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hindlimb; Hyperalgesia; Loperamide;

1999
Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP;

1999
Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:4

    Topics: Administration, Topical; Analgesics, Opioid; Animals; Burns; Hindlimb; Hyperalgesia; Injections, Spi

2002