loperamide has been researched along with Allodynia in 13 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous reports have shown that systemic administration of morphine can prevent the thermal hyperalgesia induced by the development of an osteosarcoma in C3H/HeJ mice after the implantation of NCTC 2472 cells." | 3.72 | Peripheral opioids act as analgesics in bone cancer pain in mice. ( Baamonde, A; García, E; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2003) |
| "The present results suggest that thermal hyperalgesia in experimental neuropathic pain can be reduced through activation of peripheral delta-opioid receptors." | 1.34 | Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. ( Hruby, VJ; Porreca, F; Shinoda, K, 2007) |
| "Loperamide was more potent in male than female arthritic rats at producing antihyperalgesia." | 1.33 | Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats. ( Cook, CD; Nickerson, MD, 2005) |
| "Treatment with loperamide on the normal paw produced short-lasting hypoalgesia, but the effect was not reversible with naloxone." | 1.30 | Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide. ( Nozaki-Taguchi, N; Yaksh, TL, 1999) |
| "Loperamide has potential therapeutic use as a peripherally selective opiate antihyperalgesic agent that lacks many of the side effects generally associated with administration of centrally acting opiates." | 1.30 | Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. ( Burgos, LC; Cassel, JA; Daubert, JD; DeHaven, RN; DeHaven-Hudkins, DL; Mansson, E; Nagasaka, H; Yaksh, T; Yu, G, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, SQ | 1 |
| Yang, F | 2 |
| Perez, FM | 1 |
| Xu, Q | 1 |
| Shechter, R | 1 |
| Cheong, YK | 1 |
| Carteret, AF | 2 |
| Dong, X | 2 |
| Sweitzer, SM | 1 |
| Raja, SN | 3 |
| Guan, Y | 3 |
| Kumar, R | 1 |
| Reeta, KH | 1 |
| Ray, SB | 1 |
| Chung, C | 1 |
| McKelvy, AD | 1 |
| Ringkamp, M | 2 |
| Hartke, TV | 2 |
| Hama, A | 1 |
| Tal, M | 1 |
| Wooten, M | 1 |
| McKelvy, A | 1 |
| Turnquist, BP | 1 |
| Meyer, RA | 1 |
| Menéndez, L | 3 |
| Lastra, A | 1 |
| Hidalgo, A | 3 |
| Meana, A | 1 |
| García, E | 1 |
| Baamonde, A | 3 |
| Cook, CD | 1 |
| Nickerson, MD | 1 |
| Shinoda, K | 1 |
| Hruby, VJ | 1 |
| Porreca, F | 1 |
| Juárez, L | 2 |
| García, V | 1 |
| Curto-Reyes, V | 1 |
| García-Pérez, E | 1 |
| Fresno, MF | 1 |
| Nozaki-Taguchi, N | 2 |
| Yaksh, TL | 2 |
| DeHaven-Hudkins, DL | 1 |
| Burgos, LC | 1 |
| Cassel, JA | 1 |
| Daubert, JD | 1 |
| DeHaven, RN | 1 |
| Mansson, E | 1 |
| Nagasaka, H | 1 |
| Yu, G | 1 |
| Yaksh, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Loperamide Gel for Pain Reduction During Repeat Finger Lancing: A Randomized Double Blind Trial[NCT02711891] | Early Phase 1 | 34 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for loperamide and Allodynia
| Article | Year |
|---|---|
Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Calcium; Dizocilpine Maleate; Dose | 2013 |
Chronic spinal infusion of loperamide alleviates postsurgical pain in rats.
Topics: Analgesics; Animals; Hyperalgesia; Infusions, Spinal; Loperamide; Male; Pain, Postoperative; Rats; R | 2014 |
Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hot Temperature; | 2012 |
The challenge of understanding peripherally mediated antinociception: commentary on a paper by Chung et al. (2012, this issue).
Topics: Analgesia; Analgesics; Animals; Hyperalgesia; Loperamide; Male; Peripheral Nerve Injuries; Spinal Ne | 2012 |
Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers.
Topics: Analgesics, Opioid; Animals; Electrophysiological Phenomena; Hyperalgesia; Injections; Loperamide; M | 2012 |
Peripheral opioids act as analgesics in bone cancer pain in mice.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cell Culture Techniques; Hyperalgesia; Loperamide; Mice | 2003 |
Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats.
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Body Weight; Butorphanol; Dose-Response Relati | 2005 |
Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2007 |
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Ad | 2007 |
Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice.
Topics: Analgesics, Opioid; Animals; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cyclic GMP; Disease M | 2008 |
Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide.
Topics: Analgesics; Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hindlimb; Hyperalgesia; Loperamide; | 1999 |
Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; | 1999 |
Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Burns; Hindlimb; Hyperalgesia; Injections, Spi | 2002 |