Compounds > isocordoin

Page last updated: 2024-11-11

isocordoin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

isocordoin: a metabolite biotransformed from Morus nigra; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Morus	genus	A plant genus of the family MORACEAE that is widely planted for shade.[MeSH]	Moraceae	The mulberry plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. They have milky latex and small, petalless male or female flowers.[MeSH]

Cross-References

ID Source	ID
PubMed CID	6251270
CHEMBL ID	460618
CHEBI ID	185940
SCHEMBL ID	24075559
MeSH ID	M0403376

Synonyms (13)

Synonym
nsc270890
nsc-270890
51619-57-9
isocordoin
LMPK12120007
CHEMBL460618
CHEBI:185940
(e)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-phenylprop-2-en-1-one
52601-05-5
2-propen-1-one, 1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-phenyl-, (e)-
(e)-1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-phenyl-2-propen-1-one
(e)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-phenylprop-2-en-1-one
SCHEMBL24075559

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
chalcones	A ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID1515012	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2	Synthesis and biological activities evaluation of sanjuanolide and its analogues.
AID388001	Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID1515011	Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2	Synthesis and biological activities evaluation of sanjuanolide and its analogues.
AID1515008	Antiproliferative activity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2	Synthesis and biological activities evaluation of sanjuanolide and its analogues.
AID388002	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID388003	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID388004	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID1515009	Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2	Synthesis and biological activities evaluation of sanjuanolide and its analogues.
AID1515010	Antiproliferative activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2	Synthesis and biological activities evaluation of sanjuanolide and its analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (27.27)	29.6817
2010's	6 (54.55)	24.3611
2020's	2 (18.18)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.19 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.68 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.19)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.08	1	0	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
phloretin [no description available]	2.04	1	0	dihydrochalcones	antineoplastic agent; plant metabolite
resacetophenone resacetophenone: structure in first source. 2',4'-dihydroxyacetophenone : A dihydroxyacetophenone that is acetophenone carrying hydroxy substituents at positions 2' and 4'.	2	1	0	dihydroxyacetophenone; resorcinols	plant metabolite
ng-nitroarginine methyl ester NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.	2.08	1	0	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor
lupenone lupenone: structure in first source	2.31	1	0	triterpenoid	metabolite
atropine tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.	2.08	1	0
lupeol [no description available]	2.31	1	0	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
chalcone trans-chalcone : The trans-isomer of chalcone.	7.46	2	0	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
isoliquiritigenin [no description available]	2.04	1	0	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
isobavachalcone isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.	2.04	1	0	chalcones; polyphenol	antibacterial agent; metabolite; platelet aggregation inhibitor
2',4'-dihydroxychalcone 2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source	2	1	0
4-hydroxycordoin 4-hydroxycordoin: antibacterial and anti-inflammatory from Lonchocarpus neuroscapha Benth. (Fabaceae); structure in first source. 4-hydroxycordoin : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at position 4 and 2' and a (3-methylbut-2-en-1-yl)oxy group at position 4'. It has been isolated from Lonchocarpus neuroscapha.	2.04	1	0	aromatic ether; chalcones; polyphenol	anti-inflammatory agent; antibacterial agent; plant metabolite
4-hydroxylonchocarpin 4-hydroxylonchocarpin: structure in first source	2.04	1	0
derricidin derricidin: from Lonchocarpus sericeus; structure in first source	2.04	1	0	chalcones
Lonchocarpin lonchocarpine: has anti-bacterial, anti-inflammatory, antiproliferative, antioxidant, and antiepileptic activities; isolated from Abrus precatorius; structure in first source	2.04	1	0	chalcones
4-hydroxyderricin 4-hydroxyderricin: from Angelica keiskei; RN given refers to (E)-isomer; structure in first source	2.04	1	0	chalcones
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	2.04	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Anasarca [description not available]	0	2.25	1	0
Allodynia [description not available]	0	2.25	1	0
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	0	2.25	1	0