ketanserin has been researched along with Allodynia in 22 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated effects of topical application of ketanserin, a 5-HT2A receptor antagonist, on hyperalgesia and edema in the arthritic rat, a chronic pain model with inflammation." | 7.73 | Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. ( Hong, Y; Ji, H; Wei, H, 2006) |
| "The streptozotocin-induced diabetic rat model was used to compare the efficacy of duloxetine, 5-HT, the 5-HT(2A) receptor agonist [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)] and two antagonists (ketanserin and pruvanserin) on tactile allodynia." | 3.77 | A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy. ( Jolivalt, CG; Mixcoatl-Zecuatl, T, 2011) |
| "We investigated effects of topical application of ketanserin, a 5-HT2A receptor antagonist, on hyperalgesia and edema in the arthritic rat, a chronic pain model with inflammation." | 3.73 | Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. ( Hong, Y; Ji, H; Wei, H, 2006) |
| "The involvement of opioid receptor activation in the antinociceptive effect of either fluvoxamine, a selective serotonin reuptake inhibitor, or serotonin (5-HT) on thermal hyperalgesia and mechanical allodynia in a model of neuropathic pain in mice induced by sciatic nerve ligation was examined." | 3.73 | Possible involvement of opioidergic systems in the antinociceptive effect of the selective serotonin reuptake inhibitors in sciatic nerve-injured mice. ( Kamei, J; Nozaki, C, 2006) |
| "The behavioral signs of cold allodynia in Sprague-Dawley (SD) rats were induced by a single injection of oxaliplatin (6 mg/kg, i." | 1.40 | Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats. ( Go, D; Kim, SK; Lee, JH; Li, DX; Min, BI; Quan, FS; Yoon, H, 2014) |
| "injection abolished carrageenan-evoked hyperalgesia at the doses, at which the drugs failed to alter the hypersensitivity when they were given alone." | 1.39 | Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats. ( Hong, Y; Wang, D; Zhou, X, 2013) |
| "Peripherally released 5HT induces thermal hyperalgesia, possibly via modulation of the transient receptor potential V1 (TRPV1) channel, which is gated by various noxious stimuli, including capsaicin." | 1.38 | Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat. ( Chen, PB; Hargreaves, KM; Loyd, DR, 2012) |
| "Pretreatment with ketanserin significantly attenuated these effects." | 1.36 | Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache. ( le Grand, SM; Srikiatkhachorn, A; Supornsilpchai, W, 2010) |
| "Hyperalgesia due to nerve injury and hyperalgesia due to inflammation may share some common features." | 1.30 | Hyperalgesia due to nerve damage: role of nerve growth factor. ( Hu, D; Rush, AR; Theodosiou, M; Tracey, JD; Walker, SJ; Zhou, FX, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 15 (68.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Wang, D | 3 |
| Zhou, X | 1 |
| Hong, Y | 6 |
| Bektas, N | 1 |
| Arslan, R | 1 |
| Ozturk, Y | 1 |
| Sun, YH | 1 |
| Li, HS | 1 |
| Zhu, C | 1 |
| Hu, W | 2 |
| Yang, J | 1 |
| Zhao, GL | 1 |
| Lu, GJ | 1 |
| Wu, SX | 1 |
| Dong, YL | 1 |
| Nishijima, CM | 1 |
| Ganev, EG | 1 |
| Mazzardo-Martins, L | 1 |
| Martins, DF | 1 |
| Rocha, LR | 1 |
| Santos, AR | 1 |
| Hiruma-Lima, CA | 1 |
| Lee, JH | 1 |
| Li, DX | 1 |
| Yoon, H | 1 |
| Go, D | 1 |
| Quan, FS | 1 |
| Min, BI | 1 |
| Kim, SK | 1 |
| Diniz, DA | 1 |
| Petrocchi, JA | 1 |
| Navarro, LC | 1 |
| Souza, TC | 1 |
| Castor, MG | 1 |
| Perez, AC | 1 |
| Duarte, ID | 1 |
| Romero, TR | 1 |
| Huang, BQ | 1 |
| Wu, B | 1 |
| Cervantes-Durán, C | 2 |
| Vidal-Cantú, GC | 2 |
| Godínez-Chaparro, B | 1 |
| Granados-Soto, V | 2 |
| Huang, J | 1 |
| Cai, Q | 1 |
| Chen, Y | 1 |
| Gao, Y | 2 |
| Ji, H | 2 |
| Supornsilpchai, W | 1 |
| le Grand, SM | 1 |
| Srikiatkhachorn, A | 1 |
| Mixcoatl-Zecuatl, T | 1 |
| Jolivalt, CG | 1 |
| Loyd, DR | 1 |
| Chen, PB | 1 |
| Hargreaves, KM | 1 |
| Chen, T | 1 |
| Quirion, R | 1 |
| Barchini, J | 1 |
| Tchachaghian, S | 1 |
| Shamaa, F | 1 |
| Jabbur, SJ | 1 |
| Meyerson, BA | 1 |
| Song, Z | 1 |
| Linderoth, B | 1 |
| Saadé, NE | 1 |
| Pineda-Farias, JB | 1 |
| Bravo-Hernández, M | 1 |
| Quiñonez-Bastidas, GN | 1 |
| Barragán-Iglesias, P | 1 |
| Déciga-Campos, M | 1 |
| Díaz-Reval, MI | 1 |
| Ventura-Martínez, R | 1 |
| López-Muñoz, FJ | 1 |
| Nitanda, A | 1 |
| Yasunami, N | 1 |
| Tokumo, K | 1 |
| Fujii, H | 1 |
| Hirai, T | 1 |
| Nishio, H | 1 |
| Wei, H | 1 |
| Nozaki, C | 1 |
| Kamei, J | 1 |
| Theodosiou, M | 1 |
| Rush, AR | 1 |
| Zhou, FX | 1 |
| Hu, D | 1 |
| Walker, SJ | 1 |
| Tracey, JD | 1 |
22 other studies available for ketanserin and Allodynia
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats.
Topics: Analgesics; Animals; Arthritis; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Hy | 2013 |
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Respons | 2014 |
The analgesia effect of duloxetine on post-operative pain via intrathecal or intraperitoneal administration.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Duloxetine Hydrochloride; Hyperalgesia | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Aci | 2014 |
Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats.
Topics: Acupuncture Analgesia; Acupuncture Points; Animals; Apitherapy; Bee Venoms; Cold Temperature; Fenclo | 2014 |
Serotonin induces peripheral mechanical antihyperalgesic effects in mice.
Topics: Animals; Biphenyl Compounds; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Ketanseri | 2015 |
[Effects of blockade of 5-HT2A receptors in inflammatory site on complete Freund's adjuvant-induced chronic hyperalgesia and neuropeptide Y expression in the spinal dorsal horn in rats].
Topics: Animals; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Ketanserin | 2015 |
Role of spinal 5-HT2 receptors subtypes in formalin-induced long-lasting hypersensitivity.
Topics: Animals; Female; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Ketanserin; Pain Measurement; Pyrimidi | 2016 |
Treatment with ketanserin produces opioid-mediated hypoalgesia in the late phase of carrageenan-induced inflammatory hyperalgesia in rats.
Topics: Analgesia; Animals; Carrageenan; Disease Models, Animal; Hot Temperature; Hyperalgesia; Inflammation | 2009 |
Topical and systemic administrations of ketanserin attenuate hypersensitivity and expression of CGRP in rats with spinal nerve ligation.
Topics: Administration, Topical; Animals; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Gene Expression | 2010 |
Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cerebral Cortex; Cerebrovascular Circulation; Dise | 2010 |
A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy.
Topics: Amphetamines; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Duloxetine Hydrochlor | 2011 |
Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat.
Topics: Animals; Capsaicin; Female; Hyperalgesia; Ketanserin; Male; Pain Measurement; Rats; Rats, Sprague-Da | 2012 |
Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT(2A) receptor antagonist ketanserin in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Denervation; Disease Models, Animal; Ganglia, Spinal; Hype | 2012 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; | 2012 |
Evidence for the participation of peripheral 5-HT₂A, 5-HT₂B, and 5-HT₂C receptors in formalin-induced secondary mechanical allodynia and hyperalgesia.
Topics: Amphetamines; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Fluoxetine; Formaldehyd | 2013 |
Participation of the serotonin system in rofecoxib-induced antinociception.
Topics: Analgesics; Animals; Cyclooxygenase Inhibitors; Female; Hyperalgesia; Indoles; Injections, Intravent | 2004 |
Contribution of the peripheral 5-HT 2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain.
Topics: Animals; Binding Sites; Binding, Competitive; Denervation; Disease Models, Animal; Drug Interactions | 2005 |
Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats.
Topics: Administration, Topical; Analysis of Variance; Animals; Arthritis, Experimental; Behavior, Animal; C | 2006 |
Possible involvement of opioidergic systems in the antinociceptive effect of the selective serotonin reuptake inhibitors in sciatic nerve-injured mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fluvoxamine; Hyperalgesia; Injections, Spinal | 2006 |
Hyperalgesia due to nerve damage: role of nerve growth factor.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Humans; Hyperalgesia; Immune Ser | 1999 |