glucose, (beta-d)-isomer has been researched along with Allodynia in 87 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (6.90) | 18.2507 |
| 2000's | 30 (34.48) | 29.6817 |
| 2010's | 37 (42.53) | 24.3611 |
| 2020's | 14 (16.09) | 2.80 |
| Authors | Studies |
|---|---|
| Aloisi, AM; Mollica, A; Nicoletti, M; Pieretti, S; Saviano, A; Stefanucci, A | 1 |
| Arena, AC; de Matos Balsalobre, N; Dos Santos, E; Konkiewitz, EC; Leite Kassuya, CA; Mariano Dos Santos, S; Nazari Formagio, AS; Ziff, EB | 1 |
| Arena, AC; Bernal, LPT; Cardoso, CAL; Fraga, TL; Kassuya, CAL; Leitão, MM; Lencina, JDS; Radai, JAS; Silva-Filho, SE | 1 |
| Alves, MS; Amaral, FA; Barbosa, BCM; Braga, AD; Braga, AV; Carneiro, FS; Carvalho, AFS; Coelho, MM; Costa, SOAM; da Costa, YFG; Lino, CI; Machado, RR; Melo, ISF; Morais, MI; Moreira, NF; Oliveira, RB; Oliveira, VLS; Queiroz-Junior, CM; Rodrigues, FF; Sousa, LP; Zaidan, I | 1 |
| B Carvalho, D; Baroni, ACM; Bonfá, IS; Candeloro, L; das Neves, AR; Felipe, JL; Ferreira, GIS; Lencina, JS; Lossavaro, PKMB; Silva-Filho, SE; Souza, MIL; Toffoli-Kadri, MC | 1 |
| Correa, LB; Cunha, TM; Henriques, MG; Manchope, MF; Rosas, EC; Seito, LN; Verri, WA | 1 |
| Aguero Ito, CN; Arena, AC; Dos Santos, E; Leitão, MM; Leite Kassuya, CA; Nakamura Cuman, RK; Nazari Formagio, AS; Oliveira, RJ; Silva-Comar, FMS; Silva-Filho, SE | 1 |
| Ambrósio, SR; Andrade E Silva, ML; Arruda, C; Banderó-Filho, VC; Bastos, JK; Carneiro, LJ; Faloni de Andrade, S; Lemos, M; Mangabeira da Silva, JJ; Mariano, RL; Ribeiro, VP; Sasse, A; Schneider, AH; Sheridan, H; Símaro, GV; Wagner de Souza Wanderley, C | 1 |
| Cavalcante, ALC; de Araújo, JCB; de Castro Brito, GA; Gondim, DV; Lisboa, MRP; Vale, ML | 1 |
| Angioni, C; Geisslinger, G; Osthues, T; Pierre, SC; Scholich, K; Sisignano, M; Thomas, D; Toewe, A; Zimmer, B | 1 |
| Brüne, B; Cohnen, J; Ferreiros, N; Geisslinger, G; Hohmann, S; Kern, K; Osthues, T; Pierre, S; Schäfer, SMG; Scholich, K; Sisignano, M; Tarighi, N; Weigert, A | 1 |
| Chun, S; Kwon, YB | 1 |
| Bifulco, G; Chini, MG; De Vita, S; Di Giannuario, A; Maione, F; Mascolo, N; Minosi, P; Pieretti, S; Raucci, F | 1 |
| Bangsow, T; Geisslinger, G; Heidler, J; Kallenborn-Gerhardt, W; Lu, R; Schmidtko, A; Syhr, KM; von Melchner, H | 1 |
| Denis, CV; Geisslinger, G; Linke, B; Meyer dos Santos, S; Nieswandt, B; Pierre, S; Scholich, K; Stegner, D; Suo, J; Zhang, DD | 1 |
| Arriaga, AM; Arriaga, NC; Benevides, NM; Bezerra, MM; Brito, GA; Chaves, HV; Cristino-Filho, G; do Val, DR; Lemos, JC; Pereira, KM; Pinto, VP; Rios, LC; Santiago, GM; Silva, AA; Silva, FR; Vasconcelos, JN | 1 |
| Berg, BM; Bruckert, M; Chichlowski, M; Kannampalli, P; Miranda, A; Pochiraju, S; Rudolph, C; Sengupta, JN | 1 |
| Figueiredo, MJ; Kanashiro, A; Malvar, Ddo C; Souza, GE | 1 |
| Li, ST; Wang, F; Wang, SJ; Yang, HY | 1 |
| Beck, KF; Boosen, M; Geisslinger, G; Hohmann, SW; Kallenborn-Gerhardt, W; Köhler, Y; Longen, S; Pfeilschifter, J; Schmidtko, A; Syhr, KMJ | 1 |
| Jeong, YC; Kwon, YB; Son, JS | 1 |
| Bressan, E; Cury, Y; Fischer, MJM; Kichko, TI; Kistner, K; Lewis, RJ; Picolo, G; Reeh, PW; Teixeira, NB; Touska, F; Vetter, I; Zimmermann, K | 1 |
| Bukowska-Strakova, K; Filipek, B; Głuch-Lutwin, M; Kieć-Kononowicz, K; Kubacka, M; Mogilski, S; Tyszka-Czochara, M; Więcek, M; Łażewska, D | 1 |
| Herschman, HR; Ishikawa, TO; Jain, NK; Spigelman, I | 1 |
| Gebhart, GF; Greenwood-van Meerveld, B; Hicks, GA; Johnson, A; McLean, PG; Winchester, WJ | 1 |
| Carson, JR; Codd, EE; Colburn, RW; Dax, SL; Flores, CM; Gallantine, EL; Meert, TF; Molino, L; Pullan, S; Razler, CM; Stone, DJ; Van Besien, CR; Wade, PR; Zhang, SP | 1 |
| Feng, B; Gebhart, GF; Shinoda, M | 1 |
| Brenneis, C; Coste, O; Marian, C; Möser, C; Niederberger, E; Zulauf, L | 1 |
| Cunha, FQ; Cunha, TM; Ferreira, SH; Lemos, HP; Pinto, LG; Verri, WA; Vieira, SM | 1 |
| Betz, H; Del Turco, D; Deller, T; Gao, W; Geisslinger, G; Kallenborn-Gerhardt, W; Laube, B; Lorenz, J; Lu, R; Schmidtko, A; Weiland, J | 1 |
| Bailey, AL; Bennett, GJ; Binik, YM; Crissman, HP; Farmer, MA; MacIntyre, LC; Milagrosa, ZE; Mogil, JS; Ribeiro-da-Silva, A; Taylor, AM; Tuttle, AH | 1 |
| Austin, JS; Beggs, S; Chanda, ML; Graham, AC; LaCroix-Fralish, ML; Mogil, JS; Ritchie, J; Salter, MW; Sorge, RE; Sotocinal, SG; Topham, L; Tuttle, AH | 1 |
| Cunha, FQ; Cunha, TM; Ferreira, SH; Guerrero, AT; Pinto, LG; Verri, WA; Vieira, SM; Zaperlon, AC; Zarpelon, AC | 1 |
| Brune, K; Depner, UB; Reinscheid, RK; Takeshima, H; Zeilhofer, HU | 1 |
| Geisslinger, G; Gühring, H; Kunz, S; Michaelis, M; Niederberger, E; Ritzeler, O; Schmidt, R; Tegeder, I | 1 |
| Chacur, M; Maier, SF; Marsh, H; Martin, D; Milligan, ED; Poole, S; Sloane, EM; Twining, CM; Watkins, LR | 1 |
| Coste, O; Ehnert, C; Geisslinger, G; Kruip, J; Kunz, S; Niederberger, E; Pfenninger, A; Schmidtko, A; Tegeder, I; Wendrich, TM | 1 |
| Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML | 1 |
| Eisenach, JC; McCall, C; Romero-Sandoval, EA | 1 |
| Coste, O; Geisslinger, G; Hofacker, A; Marian, C; Nguyen, HV; Scholich, K | 1 |
| Brune, K; Budinsky, L; Hess, A; Sergejeva, M; Zeilhofer, HU | 1 |
| Bradbury, EJ; Clark, AK; Gentry, C; Malcangio, M; McMahon, SB | 1 |
| Coste, O; Ehnert, C; Geisslinger, G; Marian, C; Niederberger, E; Schmidtko, A | 1 |
| Bowen, TL; Deng, H; Li, H; Strong, JA; Xie, WR; Zhang, JM | 1 |
| Bezerra, MM; Brain, SD; Girão, VC; Greenacre, S; Keeble, J; Rocha, FA | 1 |
| Alcaraz, MJ; Bustos, G; Ferrándiz, ML; Payá, M; Sanz, MJ | 1 |
| Dykstra, CL; Gebhart, GF; Meller, ST | 1 |
| Coutinho, SV; Gebhart, GF; Meller, ST | 1 |
| Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA | 1 |
| Coutinho, VS; Gebhart, FG; Urban, OM | 1 |
| Coutinho, SV; Gebhart, GF | 1 |
| Bachvarov, DR; Bélichard, P; Bouthillier, J; Faye, P; Landry, M; Marceau, F; Pruneau, D | 1 |
| Cunha, FQ; Ferreira, SH; Ribeiro, RA; Vale, ML | 1 |
| Ates, M; Brune, K; Coste, O; Görig, M; Gühring, H; Pahl, A; Rehse, K; Zeilhofer, HU | 1 |
| Coutinho, SV; Gebhart, GF; Sengupta, JN; Su, X | 1 |
| Basbaum, AI; Roderick, RE; St Lezin, E; Taylor, BK | 1 |
| Brune, K; Geisslinger, G; Gühring, H; Lötsch, J; Pahl, A; Reeh, PW; Rehse, K; Tegeder, I; Werner, U | 1 |
| Beck, DR; Gebhart, GF; Kamp, EH | 1 |
| Coutinho, SV; Gebhart, GF; Urban, MO | 1 |
| Armstrong, C; Chacur, M; Gazda, LS; Maier, SF; Milligan, ED; Tracey, KJ; Wang, H; Watkins, LR | 1 |
| Randich, A; Turnbach, ME | 1 |
| Hara, K; Haranishi, Y; Terada, T | 1 |
| Chang, S; Chen, Z; Jing, B; Li, X; Lin, Y; Pan, Y; Qian, G; Shi, H; Zhang, D; Zhao, G; Zheng, Y | 1 |
| Chen, G; Lu, K; Wang, YT; Yao, DD; Zhang, SX | 1 |
| Gao, KX; Gong, MZ; Ren, P; Sun, HT; Yu, C; Zhang, Y; Zhao, X | 1 |
| Cheng, J; Liu, P; Ma, S; Zhou, J | 1 |
| Chen, Z; Koivisto, A; Pertovaara, A; Wei, H | 1 |
| Fan, YX; Han, Y; Hu, L; Liu, B; Liu, H; Liu, WT; Pan, X; Qian, C; Teng, P; Wang, C; Wu, XF; Yang, M; Zhang, G | 1 |
| Fan, YX; Han, Y; Hu, L; Li, QP; Liu, WT; Yang, YJ; Zhu, SH | 1 |
| Bujalska-Zadrożny, M; Czerwińska, ME; Gąsińska, E; Kiss, AK; Krawczyk, P; Leśniak, A; Naruszewicz, M | 1 |
| Cai, Y; Gu, YF; Hu, L; Jiang, CY; Kong, X; Liu, WT; Wu, D; Zhang, GQ; Zhang, S; Zhou, D | 1 |
| Cai, GJ; Chen, YF; Liu, DH; Wang, XW; Wu, Q; Yang, C; Yang, Y; Zhang, JY | 1 |
| He, ZW; Li, SP; Liao, KJ; Ling, Q; Wang, X; Wei, W | 1 |
| Chopade, AR; Sayyad, FJ | 1 |
| Amin, B; Hosseinzadeh, H; Poureshagh, E | 1 |
| Bruschetta, G; Cordaro, M; Crupi, R; Cuzzocrea, S; Esposito, E; Gugliandolo, E; Impellizzeri, D; Siracusa, R | 1 |
| Bergonzi, MC; Bilia, AR; Galeotti, N; Ghelardini, C; Iacopi, R; Isacchi, B | 1 |
| Feng, D; Li, X; Li, YJ; Shi, WL; Sun, T; Wang, J; Wang, JB; Wu, YM; Zhao, MG | 1 |
| Andoh, T; Kobayashi, N; Kuraishi, Y; Uta, D | 1 |
| Bian, ZX; Chen, HL; Li, Z; Sung, JJ; Xu, HX; Zhang, HQ; Zhang, XJ | 1 |
| Bergonzi, MC; Bilia, AR; Galeotti, N; Ghelardini, C; Iacopi, R; Isacchi, B; Norcini, M; Vincieri, FF; Vivoli, E | 1 |
| Chen, J; Mu, DG; Yin, W; Yu, HY | 1 |
| Duan, JH; Han, WJ; Hu, SJ; Luo, C; Miao, B; Sun, W; Wang, WT; Wang, XC; Ye, X | 1 |
| Cechinel Filho, V; de Campos Buzzi, F; Klein-Júnior, LC; Moreira, J | 1 |
| Cao, Y; Lv, C; Wang, HN; Zhang, J | 1 |
| Chen, J; Liu, DN; Liu, MG; Qi, C; Shang, GW; Song, ZJ; Wang, Y; Yu, HY; Zhang, KP | 1 |
| Bian, ZX; Leung, WM; Li, Z; Liu, L; Xu, HX; Zhang, XJ | 1 |
87 other study(ies) available for glucose, (beta-d)-isomer and Allodynia
| Article | Year |
|---|---|
Calceolarioside A, a Phenylpropanoid Glycoside from
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Caffeic Acids; Calceolariaceae; Carrageenan; Edema; Glucosides; Glycosides; Hyperalgesia; Mice; Pain; Plant Extracts; Zymosan | 2022 |
Potential anti-arthritic and analgesic properties of essential oil and viridiflorol obtained from Allophylus edulis leaves in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dexamethasone; Dihydroxyphenylalanine; Disease Models, Animal; Edema; Formaldehyde; Headache; Hyperalgesia; Inflammation; Mice; Morphine Derivatives; Oils, Volatile; Plant Extracts; Toothache; Tumor Necrosis Factor-alpha; Zymosan | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Edema; Ethanol; Formaldehyde; Hyperalgesia; Mice; Peritonitis; Plant Extracts; Pleurisy; Sapindaceae; Zymosan | 2023 |
A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Topics: Animals; Anti-Bacterial Agents; Arthritis; Clindamycin; Edema; Hyperalgesia; Inflammation; Lipopolysaccharides; Mice; Neutrophil Infiltration; NF-kappa B; Tumor Necrosis Factor-alpha; Zymosan | 2023 |
1,4-Diaryl-1,2,3-triazole neolignan-celecoxib hybrids inhibit experimental arthritis induced by zymosan.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Edema; Hydrogen Peroxide; Hyperalgesia; Lignans; Zymosan | 2023 |
Methyl gallate attenuates inflammation induced by Toll-like receptor ligands by inhibiting MAPK and NF-Κb signaling pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Edema; Gallic Acid; Hyperalgesia; Inflammation; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptors; Zymosan | 2020 |
Analgesic and anti-inflammatory articular effects of essential oil and camphor isolated from Ocimum kilimandscharicum Gürke leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthralgia; Camphor; Carrageenan; Disease Models, Animal; Edema; Hyperalgesia; Inflammation; Joints; Knee Injuries; Leukocyte Rolling; Leukocytes; Male; Mice; Neutrophils; Nitric Oxide; Ocimum; Oils, Volatile; Plant Leaves; Synovial Fluid; Zymosan | 2021 |
Antinociceptive and anti-inflammatory activities of Copaifera pubiflora Benth oleoresin and its major metabolite ent-hardwickiic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Behavior, Animal; Brazil; Carrageenan; Cell Line; Cytokines; Diterpenes; Edema; Fabaceae; Formaldehyde; Humans; Hyperalgesia; Locomotion; Medicine, Traditional; Mice; Mice, Inbred BALB C; NF-kappa B; Plant Extracts; Zymosan | 2021 |
Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: A comparison between two phlogistic agents.
Topics: Animals; Arthritis; Carrageenan; Disease Models, Animal; Hyperalgesia; Injections, Intra-Articular; Macrophages; Male; Microglia; Nociception; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Rats, Wistar; Temporomandibular Joint Disorders; Trigeminal Ganglion; Zymosan | 2017 |
The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Female; Freund's Adjuvant; Hot Temperature; Humans; Hyperalgesia; Inflammation; Linoleic Acid; Male; Mice; Oleic Acids; Oxidation-Reduction; Pain; Phenylurea Compounds; Piperidines; Protein Kinase C; Sensory Receptor Cells; TRPV Cation Channels; Zymosan | 2018 |
The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.
Topics: Analysis of Variance; Animals; Apoptosis; Cell Cycle Proteins; Cell Polarity; Chemotaxis; Cytokines; Hyperalgesia; Inflammation; Lactic Acid; Lipids; Macrophages; Mice; Mice, Inbred C57BL; Neutrophils; Phagocytosis; Phenotype; Receptors, G-Protein-Coupled; Zymosan | 2018 |
The CCL2 elevation in primary afferent fibers produces zymosan-induced hyperalgesia through microglia-mediated neuronal activation in the spinal dorsal horn.
Topics: Animals; Axons; Chemokine CCL2; Chemokines; Ganglia, Spinal; Hyperalgesia; Inflammation; Macrophage Activation; Male; Microglia; Neuralgia; Neurons; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Dorsal Horn; Zymosan | 2019 |
Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemokines; Edema; Formaldehyde; Glycyrrhizic Acid; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Molecular Docking Simulation; Peritoneal Cavity; Zymosan | 2019 |
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.
Topics: Activating Transcription Factor 3; Animals; Antioxidants; Female; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Nociception; Nuclear Proteins; Peripheral Nerve Injuries; Peroxidases; Reactive Oxygen Species; Sensory Receptor Cells; Up-Regulation; Zymosan | 2013 |
Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation.
Topics: Animals; CD11b Antigen; Cell Movement; Edema; Hyperalgesia; Inflammation; Membrane Glycoproteins; Mice; Mice, Mutant Strains; Neutrophils; Pain; Zymosan | 2014 |
Tephrosia toxicaria Pers. reduces temporomandibular joint inflammatory hypernociception: the involvement of the HO-1 pathway.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Heme Oxygenase-1; Hyperalgesia; Inflammation; Male; Metabolic Networks and Pathways; Mice; Phytotherapy; Plant Preparations; Protoporphyrins; Rats; Rats, Wistar; Temporomandibular Joint Disorders; Tephrosia; Zymosan | 2014 |
Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Hyperalgesia; Inflammation; Intestines; Lacticaseibacillus rhamnosus; Manometry; Neurotransmitter Agents; Prebiotics; Probiotics; Rats; Rats, Sprague-Dawley; Visceral Pain; Zymosan | 2014 |
Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats.
Topics: Animals; Arthritis; Body Temperature; Corticotropin-Releasing Hormone; Cytokines; Disease Models, Animal; Endothelin-1; Fever; Hyperalgesia; Male; Rats, Wistar; Zymosan | 2015 |
Acupoint Specificity on Colorectal Hypersensitivity Alleviated by Acupuncture and the Correlation with the Brain-Gut Axis.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Brain; Colonic Diseases; Electromyography; Gastrointestinal Diseases; Gene Expression; Genes, fos; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Physical Stimulation; Rectal Diseases; Zymosan | 2015 |
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Hydrogen Sulfide; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neuralgia; Pain Measurement; Spinal Cord; Up-Regulation; Zymosan | 2015 |
The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ethylenediamines; Hyperalgesia; Male; Microglia; Pain; Posterior Horn Cells; Rats, Sprague-Dawley; Receptors, sigma; Spinal Cord; Zymosan | 2015 |
Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.
Topics: Action Potentials; Analgesics; Animals; Bradykinin; Calcium; Cells, Cultured; Disease Models, Animal; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neurons; Peptides; Transient Receptor Potential Channels; TRPA1 Cation Channel; Zymosan | 2016 |
Aryl-1,3,5-triazine ligands of histamine H
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclic AMP; Guinea Pigs; Histamine Antagonists; Hyperalgesia; Inflammation; Interleukin-1beta; Ligands; Lipopolysaccharides; Male; Mice; Nitric Oxide; Pain; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptors, Histamine; Triazines; Tumor Necrosis Factor-alpha; Zymosan | 2017 |
COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.
Topics: Animals; Blotting, Western; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Gene Expression Regulation, Enzymologic; Hindlimb; Hyperalgesia; Inflammation; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Zymosan | 2008 |
Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Colitis; Colon; Dilatation, Pathologic; E-Selectin; Endothelial Cells; Gastrointestinal Motility; Humans; Hyperalgesia; Intercellular Adhesion Molecule-1; Leukocytes; Male; Polyethylene Glycols; Purines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological; Trinitrobenzenesulfonic Acid; Zymosan | 2009 |
JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic toler
Topics: Alfentanil; Analgesics, Opioid; Animals; Azabicyclo Compounds; Cricetinae; Drug Tolerance; Gastrointestinal Motility; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Hyperalgesia; Irritants; Male; Mice; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta; Respiratory Insufficiency; Seizures; Self Administration; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthenes; Zymosan | 2009 |
Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse.
Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Central Nervous System; Colon; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Pressure; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Zymosan | 2009 |
Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception.
Topics: Actin Depolymerizing Factors; Animals; Cells, Cultured; Cyclic GMP; Hyperalgesia; Neurites; Neurons; Nitric Oxide; Nitric Oxide Donors; Pain Measurement; Phosphorylation; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Triazenes; Zymosan | 2009 |
IL-17 mediates articular hypernociception in antigen-induced arthritis in mice.
Topics: Analysis of Variance; Animals; Antibodies, Monoclonal; Antigens; Antirheumatic Agents; Arthritis; Cell Movement; Cytokines; Dinoprostone; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Infliximab; Interleukin-17; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Pain Threshold; Polysaccharides; Receptors, Tumor Necrosis Factor, Type I; Serum Albumin; Zymosan | 2010 |
Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.
Topics: Animals; Hyperalgesia; Inflammation; Mice; Mice, Knockout; Neurons; Receptors, Glycine; Spinal Cord; Synapses; Zymosan | 2012 |
Repeated vulvovaginal fungal infections cause persistent pain in a mouse model of vulvodynia.
Topics: Animals; Candida albicans; Candidiasis, Vulvovaginal; Disease Models, Animal; Female; Hyperalgesia; Inflammation; Mice; Pain; Vagina; Vulva; Vulvodynia; Zymosan | 2011 |
Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.
Topics: Analysis of Variance; Animals; Castration; Disease Models, Animal; Female; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neuralgia; Pain Measurement; Polysaccharides; RNA, Messenger; Sex Characteristics; Spinal Cord; Testosterone Propionate; Time Factors; Toll-Like Receptor 4; Zymosan | 2011 |
The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia.
Topics: Animals; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Immune System Diseases; Inflammation; Joint Diseases; Leukocyte Disorders; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandins; Receptors, G-Protein-Coupled; Time Factors; Zymosan | 2013 |
Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor.
Topics: Animals; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Pain Measurement; Reaction Time; Receptors, Opioid; Sensory Thresholds; Time Factors; Zymosan | 2003 |
Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
Topics: Active Transport, Cell Nucleus; Analgesics; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Humans; Hyperalgesia; I-kappa B Kinase; Inflammation; Injections, Intraperitoneal; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Neuralgia; NF-kappa B; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Spinal Cord; Tumor Necrosis Factor-alpha; Up-Regulation; Zymosan | 2004 |
Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
Topics: Animals; Antibodies; Behavior, Animal; Carrier Proteins; Catalase; Complement System Proteins; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Hyperalgesia; Interleukin 1 Receptor Antagonist Protein; Interleukin-6; Male; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Complement; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sciatic Nerve; Sciatic Neuropathy; Sialoglycoproteins; Superoxide Dismutase; Tumor Necrosis Factor Decoy Receptors; Zymosan | 2004 |
The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Fluorescent Antibody Technique; Hyperalgesia; Immunoblotting; Inflammation; Male; Neurofilament Proteins; Pain Measurement; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Time Factors; Zymosan | 2004 |
Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Carrageenan; Hot Temperature; Hyperalgesia; Iloprost; Immunohistochemistry; Inflammation; Interleukin-1; Joints; Male; Mice; Pain; Pain Measurement; Pentoxifylline; Peritoneal Cavity; Phosphodiesterase Inhibitors; Physical Stimulation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Zymosan | 2004 |
Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.
Topics: Adrenergic alpha-Agonists; Animals; Antibody Formation; Clonidine; Cytokines; Hyperalgesia; Leukocyte Count; Leukocytes; Male; Neuritis; Pain; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Tumor Necrosis Factor-alpha; Zymosan | 2005 |
Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats.
Topics: Animals; Blotting, Western; Cyclooxygenase 1; Cytosol; Down-Regulation; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Intramolecular Oxidoreductases; Male; Nociceptors; Oligonucleotides, Antisense; Prostaglandin-E Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Zymosan | 2005 |
Imaging of hyperalgesia in rats by functional MRI.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Cerebrovascular Circulation; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Magnetic Resonance Imaging; Male; Neural Pathways; Nociceptors; Pain Measurement; Pain Threshold; Predictive Value of Tests; Rats; Rats, Wistar; Zymosan | 2007 |
Role of spinal microglia in rat models of peripheral nerve injury and inflammation.
Topics: Animals; Citrates; Disease Models, Animal; Functional Laterality; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Microglia; Neuritis; Pain Threshold; Posterior Horn Cells; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; Zymosan | 2007 |
The glutamate transporter GLAST is involved in spinal nociceptive processing.
Topics: Amino Acid Transport System X-AG; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Neurons; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission; Zymosan | 2006 |
Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia.
Topics: Action Potentials; Animals; Cytokines; Dose-Response Relationship, Drug; Functional Laterality; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Neurons; Pain Measurement; Protein Array Analysis; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Sympathetic Fibers, Postganglionic; Time Factors; Tyrosine 3-Monooxygenase; Zymosan | 2006 |
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.
Topics: Acute Disease; Animals; Arthritis, Experimental; Hindlimb; Hyperalgesia; Injections, Intra-Articular; Knee Joint; Male; Neutrophils; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Synovial Fluid; Tyrosine; Uric Acid; Zymosan | 2007 |
Antinociceptive activity of filenadol on inflammatory pain.
Topics: Analgesics; Animals; Benzoquinones; Codeine; Formaldehyde; Hyperalgesia; Indomethacin; Inflammation; Male; Morpholines; Pain; Rats; Rats, Sprague-Dawley; Zymosan | 1995 |
Investigations of the possible role for carbon monoxide (CO) in thermal and mechanical hyperalgesia in the rat.
Topics: Animals; Carbon Monoxide; Excitatory Amino Acid Agonists; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Physical Stimulation; Protoporphyrins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Zymosan | 1994 |
Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors.
Topics: Animals; Colon; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Inflammation; Injections, Spinal; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Zymosan | 1996 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Substance P; Zymosan | 1998 |
Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Colon; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Microinjections; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Viscera; Zymosan | 1998 |
A role for spinal nitric oxide in mediating visceral hyperalgesia in the rat.
Topics: Abdominal Muscles; Animals; Colon; Enzyme Inhibitors; Hindlimb; Hyperalgesia; Injections; Injections, Spinal; Male; Muscle Contraction; Muscle, Skeletal; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Spinal Cord; Viscera; Zymosan | 1999 |
Inflammatory hyperalgesia induced by zymosan in the plantar tissue of the rat: effect of kinin receptor antagonists.
Topics: Analgesics, Non-Narcotic; Animals; Bradykinin Receptor Antagonists; Female; Hyperalgesia; Inflammation; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; RNA, Messenger; Zymosan | 2000 |
Analgesic effect of thalidomide on inflammatory pain.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Carrageenan; Edema; Hot Temperature; Hyperalgesia; Male; Mice; Pain; Pain Measurement; Peritoneal Cavity; Physical Stimulation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thalidomide; Tumor Necrosis Factor-alpha; Zymosan | 2000 |
Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hot Temperature; Hyperalgesia; Indomethacin; Isoenzymes; Lysine; Membrane Proteins; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Prostaglandin-Endoperoxide Synthases; Spinal Cord; Sydnones; Transcription, Genetic; Zymosan | 2000 |
Role of sensitized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia.
Topics: Afferent Pathways; Animals; Colon; Disease Models, Animal; Hyperalgesia; Hypogastric Plexus; Inflammation; Male; Neurons, Afferent; Nociceptors; Pelvic Pain; Pressure; Rats; Rats, Sprague-Dawley; Zymosan | 2000 |
Hypoalgesia and hyperalgesia with inherited hypertension in the rat.
Topics: Animals; Blood Pressure; Edema; Hot Temperature; Hyperalgesia; Hypertension; Inflammation; Male; Neurons; Pain; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Spinal Cord; Zymosan | 2001 |
Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia.
Topics: Animals; Enzyme Inhibitors; Foot; Hot Temperature; Hyperalgesia; Inflammation; Kinetics; Lysine; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Sydnones; Zymosan | 2001 |
Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia.
Topics: Animals; Benzamides; Biomarkers; Colitis; Drug Interactions; Hyperalgesia; Injections, Spinal; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Zymosan | 2001 |
The role of CNS NMDA receptors and nitric oxide in visceral hyperalgesia.
Topics: Animals; Central Nervous System; Colon; Enzyme Inhibitors; Hyperalgesia; Male; Medulla Oblongata; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum; Spinal Cord; Touch; Viscera; Zymosan | 2001 |
A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.
Topics: Acute Disease; Animals; Catheterization; Disease Models, Animal; Dose-Response Relationship, Drug; HMGB1 Protein; Hyperalgesia; Lymph Nodes; Male; Organ Size; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Sciatica; Specific Pathogen-Free Organisms; Spleen; Zymosan | 2001 |
The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Dinoprostone; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Zymosan | 2002 |
Verbascoside administered intrathecally attenuates hyperalgesia via activating mu-opioid receptors in a rat chronic constriction injury model.
Topics: Analgesics; Animals; Biological Products; Constriction; Disease Models, Animal; Glucosides; Humans; Hyperalgesia; Male; Neuralgia; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 2022 |
Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis.
Topics: Animals; Apoptosis; Constriction; Glucosides; Hyperalgesia; Lipopolysaccharides; Monoterpenes; Neuralgia; NF-kappa B; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Sciatica; Toll-Like Receptor 4 | 2022 |
Anti-inflammatory and analgesic effect of Forsythiaside B on complete Freund's adjuvant-induced inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chronic Pain; Freund's Adjuvant; Glucosides; Hyperalgesia; Inflammation; Mice | 2023 |
Serotonergically dependent antihyperalgesic and antiallodynic effects of isoliquiritin in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Behavior, Animal; Brain; Chalcone; Disease Models, Animal; Glucosides; Hyperalgesia; Male; Mice, Inbred C57BL; Neuralgia; Pain Threshold; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Spinal Cord | 2020 |
Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Constriction; Glucosides; Hyperalgesia; Inflammasomes; Monoterpenes; Neuralgia; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2020 |
Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Flavonoids; Glucosides; Hyperalgesia; Isoflavones; Male; Rats; Rats, Wistar; Sphingolipids; Sphingosine; Spinal Cord | 2021 |
Induction of suppressor of cytokine signaling 3 via HSF-1-HSP70-TLR4 axis attenuates neuroinflammation and ameliorates postoperative pain.
Topics: Animals; Cytokines; Drug Tolerance; Glucosides; HSP70 Heat-Shock Proteins; Hyperalgesia; Inflammation; Mice; Microglia; Monoterpenes; Neuralgia; Neuroglia; Neuroimmunomodulation; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Toll-Like Receptor 4 | 2018 |
Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase-9/2 in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Glucosides; Hyperalgesia; Interleukin-1beta; Macrophage Activation; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Microglia; Monoterpenes; Pain, Postoperative; Phosphorylation; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes.
Topics: Aldehydes; Animals; Chromatography, High Pressure Liquid; Cyclopentane Monoterpenes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glucosides; Glycosides; Hyperalgesia; Iridoid Glucosides; Iridoids; Ligustrum; Male; Neuralgia; Phenols; Plant Extracts; Plant Leaves; Rats; Streptozocin | 2018 |
Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Disease Models, Animal; Down-Regulation; Encephalitis; Glucosides; Hydroxyquinolines; Hyperalgesia; Interleukin-1beta; Male; MAP Kinase Kinase Kinase 5; Monoterpenes; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Signal Transduction | 2019 |
Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.
Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glucosides; Heterocyclic Compounds, 2-Ring; Hyperalgesia; Mice; Mice, Inbred ICR; Morphine; Pain; Pain Measurement; Pain Threshold; Time Factors | 2014 |
Anti-allodynic effects of obtusifolin and gluco-obtusifolin against inflammatory and neuropathic pain.
Topics: Animals; Anthraquinones; Dose-Response Relationship, Drug; Glucosides; Hyperalgesia; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred ICR; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2014 |
Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan-induced Thermal and Mechanical Chronic Muscle Hyperalgesia.
Topics: Animals; Carrageenan; Dinoprostone; Disease Models, Animal; Glucosides; Hydrolyzable Tannins; Hyperalgesia; Inflammation; Lignans; Male; Muscle, Skeletal; Musculoskeletal Pain; Pain; Phyllanthus; Rats, Wistar | 2015 |
The Effect of Verbascoside in Neuropathic Pain Induced by Chronic Constriction Injury in Rats.
Topics: Analgesics; Animals; Apoptosis; bcl-2-Associated X Protein; Calcium-Binding Proteins; Constriction; Glial Fibrillary Acidic Protein; Glucosides; Glutathione; Hyperalgesia; Male; Malondialdehyde; Microfilament Proteins; Neuralgia; Neuroglia; Oxidative Stress; Phenols; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Spinal Cord | 2016 |
A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammation.
Topics: Active Transport, Cell Nucleus; Administration, Oral; Amides; Animals; Carrageenan; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Drug Compounding; Drug Interactions; Edema; Ethanolamines; Gene Expression Regulation, Enzymologic; Glucosides; Hyperalgesia; Inflammation; Male; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Palmitic Acids; Proteolysis; Rats; Rats, Sprague-Dawley; Stilbenes; Superoxide Dismutase; Transcription Factor RelA; Tyrosine | 2016 |
Liposomal Formulation to Increase Stability and Prolong Antineuropathic Activity of Verbascoside.
Topics: Analgesics; Animals; Drug Delivery Systems; Drug Stability; Glucosides; Hyperalgesia; Liposomes; Mice; Neuralgia; Phenols; Rats; Rats, Sprague-Dawley | 2017 |
Gastrodin relieved complete Freund's adjuvant-induced spontaneous pain by inhibiting inflammatory response.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Anxiety; Astrocytes; Benzyl Alcohols; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Freund's Adjuvant; Glial Fibrillary Acidic Protein; Glucosides; Gyrus Cinguli; Hot Temperature; Hyperalgesia; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Pain; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Touch; Tumor Necrosis Factor-alpha | 2016 |
Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A
Topics: Administration, Topical; Animals; Antineoplastic Agents; Benzoates; Demyelinating Diseases; Glucosides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoterpenes; Neuralgia; Paclitaxel; Paeonia; Phytotherapy; Plant Extracts; Receptor, Adenosine A1 | 2017 |
Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A(1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway.
Topics: Adenosine A1 Receptor Antagonists; Analgesics; Animals; Animals, Newborn; Benzoates; Brain; Bridged-Ring Compounds; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Glucosides; Glutamic Acid; Hyperalgesia; Male; MAP Kinase Signaling System; Maternal Deprivation; Mitogen-Activated Protein Kinase Kinases; Monoterpenes; Paeonia; Pain Threshold; Phosphorylation; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Reflex, Abdominal; Viscera | 2009 |
Antihyperalgesic activity of verbascoside in two models of neuropathic pain.
Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Glucosides; Hyperalgesia; Injections, Intraperitoneal; Iodoacetates; Lippia; Male; Neuralgia; Phenols; Phytotherapy; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Sciatic Nerve | 2011 |
Suppressive effects of intrathecal paeoniflorin on bee venom-induced pain-related behaviors and spinal neuronal activation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Behavior, Animal; Benzoates; Bridged-Ring Compounds; Glucosides; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Monoterpenes; Naloxone; Narcotic Antagonists; Pain; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Touch | 2011 |
Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons.
Topics: Animals; Benzyl Alcohols; Capsaicin; Diabetic Neuropathies; Glucosides; Hyperalgesia; Rats; Sensory Receptor Cells; Streptozocin | 2012 |
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Acid; Hot Temperature; Hydrolyzable Tannins; Hyperalgesia; Male; Mice; Motor Activity; Phyllanthus; Phytotherapy | 2013 |
Synergistic interaction between total glucosides and total flavonoids on chronic constriction injury induced neuropathic pain in rats.
Topics: Administration, Oral; Analgesics; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drugs, Chinese Herbal; Flavonoids; Ganglia, Spinal; Glucosides; Glycyrrhiza; Hyperalgesia; Immunohistochemistry; Ligation; Male; Neuralgia; Paeonia; Pain Perception; Pain Threshold; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sirtuin 1; Time Factors | 2013 |
Antinociceptive effects of systemic paeoniflorin on bee venom-induced various 'phenotypes' of nociception and hypersensitivity.
Topics: Analgesics; Animals; Bee Venoms; Benzoates; Bridged-Ring Compounds; Disease Models, Animal; Glucosides; Hyperalgesia; Male; Monoterpenes; Motor Activity; Naloxone; Pain Threshold; Rats; Rats, Sprague-Dawley | 2007 |
The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; Female; Glucosides; Hyperalgesia; Male; Maternal Deprivation; Monoterpenes; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Pregnancy; Rats; Rats, Sprague-Dawley; Yohimbine | 2008 |