serine has been researched along with Allodynia in 28 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV)." | 7.77 | Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. ( Kawamata, T; Kiya, T; Namiki, A; Yamakage, M, 2011) |
| "Spinal hydrogen peroxide is specifically and largely responsible for formalin-induced pain, and DAAO inhibitors produce analgesia by blocking spinal hydrogen peroxide production rather than interacting with spinal D-serine." | 3.78 | D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. ( Gong, N; Lu, JM; Wang, YC; Wang, YX, 2012) |
| " In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV)." | 3.77 | Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. ( Kawamata, T; Kiya, T; Namiki, A; Yamakage, M, 2011) |
| "Glycine inhibitory dysfunction provides a useful experimental model for studying the mechanism of dynamic mechanical allodynia, a widespread and intractable symptom of neuropathic pain." | 3.77 | Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. ( Dallel, R; Miraucourt, LS; Peirs, C; Voisin, DL, 2011) |
| "The NTG injection induced acute migraine-like pain including photophobia and mechanical hypersensitivity as reported previously." | 1.48 | AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain. ( Liu, S; Shu, H; Tang, Y; Tao, F; Xing, Y, 2018) |
| " Acute intrathecal administration of the NMDA receptor antagonist d-AP5 as well as chronic administration of the glia metabolism inhibitor fluoroacetate significantly reduced mechanical allodynia in neuropathic rats." | 1.42 | Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats. ( Amadio, A; Dallel, R; Descheemaeker, A; Lefèvre, Y; Oliet, SH; Vincent, P; Voisin, DL, 2015) |
| "Meanwhile, thermal hyperalgesia was observed from day 2 through day 10 and mechanical allodynia from day 4 through day 10." | 1.40 | Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. ( Gao, M; Maixner, DW; Weng, HR, 2014) |
| "Mechanical allodynia and thermal hyperalgesia were assessed before, after chronic constriction injury, and every 2 days during substance application." | 1.40 | Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats. ( Aragon, C; Barthel, F; Bauer, I; Brandenburger, T; Eulenburg, V; Hermanns, H; Schlösser, L; Urban, A; Werdehausen, R, 2014) |
| "Secondary mechanical allodynia resulting from a thermal stimulus (52." | 1.33 | Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005) |
| "SP potentiates the D-serine-induced thermal hyperalgesia." | 1.31 | Substance P potentiates thermal hyperalgesia induced by intrathecal administration of D-serine in rats. ( Shu, YS; Zhang, YH; Zhao, ZQ, 2001) |
| "Gabapentin is an anticonvulsant that may represent a novel class of drugs, which has novel spinal antihyperalgesic activity." | 1.30 | The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. ( Jun, JH; Yaksh, TL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 20 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, Y | 1 |
| Liu, S | 1 |
| Shu, H | 1 |
| Xing, Y | 1 |
| Tao, F | 1 |
| Al-Khrasani, M | 1 |
| Mohammadzadeh, A | 1 |
| Balogh, M | 1 |
| Király, K | 1 |
| Barsi, S | 1 |
| Hajnal, B | 1 |
| Köles, L | 1 |
| Zádori, ZS | 1 |
| Harsing, LG | 1 |
| Wang, Y | 2 |
| Wu, J | 1 |
| Guo, R | 1 |
| Zhao, Y | 1 |
| Zhang, M | 1 |
| Chen, Z | 1 |
| Wu, A | 1 |
| Yue, Y | 1 |
| Hopkins, SC | 1 |
| Zhao, FY | 1 |
| Bowen, CA | 1 |
| Fang, X | 1 |
| Wei, H | 1 |
| Heffernan, ML | 1 |
| Spear, KL | 1 |
| Spanswick, DC | 1 |
| Varney, MA | 1 |
| Large, TH | 1 |
| Weng, HR | 1 |
| Gao, M | 1 |
| Maixner, DW | 1 |
| Barthel, F | 1 |
| Urban, A | 1 |
| Schlösser, L | 1 |
| Eulenburg, V | 1 |
| Werdehausen, R | 1 |
| Brandenburger, T | 1 |
| Aragon, C | 1 |
| Bauer, I | 1 |
| Hermanns, H | 1 |
| Takahashi, Y | 1 |
| Hara, K | 1 |
| Haranishi, Y | 1 |
| Terada, T | 1 |
| Obara, G | 1 |
| Sata, T | 1 |
| Wang, XQ | 1 |
| Zhong, XL | 1 |
| Li, ZB | 1 |
| Wang, HT | 1 |
| Zhang, J | 1 |
| Li, F | 1 |
| Zhang, JY | 1 |
| Dai, RP | 1 |
| Xin-Fu, Z | 1 |
| Li, CQ | 1 |
| Li, ZY | 1 |
| Bi, FF | 1 |
| Lefèvre, Y | 1 |
| Amadio, A | 1 |
| Vincent, P | 1 |
| Descheemaeker, A | 1 |
| Oliet, SH | 1 |
| Dallel, R | 2 |
| Voisin, DL | 2 |
| Moon, JY | 2 |
| Choi, SR | 2 |
| Roh, DH | 2 |
| Yoon, SY | 2 |
| Kwon, SG | 2 |
| Choi, HS | 2 |
| Kang, SY | 2 |
| Han, HJ | 2 |
| Kim, HW | 1 |
| Beitz, AJ | 2 |
| Oh, SB | 1 |
| Lee, JH | 2 |
| Kronschläger, MT | 1 |
| Drdla-Schutting, R | 1 |
| Gassner, M | 1 |
| Honsek, SD | 1 |
| Teuchmann, HL | 1 |
| Sandkühler, J | 1 |
| Potvin, S | 1 |
| Larouche, A | 1 |
| Normand, E | 1 |
| de Souza, JB | 1 |
| Gaumond, I | 1 |
| Grignon, S | 1 |
| Marchand, S | 1 |
| Peng, H | 1 |
| Lewandrowski, U | 1 |
| Müller, B | 1 |
| Sickmann, A | 1 |
| Walz, G | 1 |
| Wegierski, T | 1 |
| Sunakawa, N | 1 |
| Naono, R | 1 |
| Ikeda, T | 1 |
| Matsushima, O | 1 |
| Sakoda, S | 1 |
| Nishimori, T | 1 |
| Atianjoh, FE | 1 |
| Yaster, M | 1 |
| Zhao, X | 1 |
| Takamiya, K | 1 |
| Xia, J | 1 |
| Gauda, EB | 1 |
| Huganir, RL | 1 |
| Tao, YX | 1 |
| Kiya, T | 2 |
| Kawamata, T | 2 |
| Namiki, A | 1 |
| Yamakage, M | 1 |
| Miraucourt, LS | 1 |
| Peirs, C | 1 |
| Gupta, LK | 1 |
| Gupta, R | 1 |
| Tripathi, CD | 1 |
| Lu, JM | 1 |
| Gong, N | 1 |
| Wang, YC | 1 |
| Wang, YX | 1 |
| Muth-Selbach, U | 1 |
| Dybek, E | 1 |
| Kollosche, K | 1 |
| Stegmann, JU | 1 |
| Holthusen, H | 1 |
| Lipfert, P | 1 |
| Zeilhofer, HU | 1 |
| Jones, TL | 1 |
| Sorkin, LS | 1 |
| Guo, JD | 1 |
| Wang, H | 1 |
| Zhang, YQ | 1 |
| Zhao, ZQ | 2 |
| Lu, Y | 1 |
| Sun, YN | 1 |
| Wu, X | 1 |
| Sun, Q | 1 |
| Liu, FY | 1 |
| Xing, GG | 1 |
| Wan, Y | 1 |
| Partridge, BJ | 1 |
| Chaplan, SR | 1 |
| Sakamoto, E | 1 |
| Yaksh, TL | 2 |
| Jun, JH | 1 |
| Zhang, YH | 1 |
| Shu, YS | 1 |
1 review available for serine and Allodynia
| Article | Year |
|---|---|
Glycine transporter inhibitors: A new avenue for managing neuropathic pain.
Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Hyperalgesia; Neuralgia; Neuro | 2019 |
27 other studies available for serine and Allodynia
| Article | Year |
|---|---|
AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain.
Topics: Animals; Avoidance Learning; Calcium; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Locomot | 2018 |
Surgical incision induces phosphorylation of AMPA receptor GluR1 subunits at Serine-831 sites and GluR1 trafficking in spinal cord dorsal horn via a protein kinase Cγ-dependent mechanism.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Pain Threshold; Pain, Postoperative; Phosphoryl | 2013 |
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarb | 2013 |
Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Disease Models, Animal; Drug Administration R | 2014 |
Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Constriction, Pathologic; Dose-Response Relationship, | 2014 |
Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine Plasma Membra | 2015 |
Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats.
Topics: Anhedonia; Animals; Anti-Anxiety Agents; Anxiety; Dietary Sucrose; Disease Models, Animal; Hippocamp | 2015 |
Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats.
Topics: Animals; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Racem | 2015 |
Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.
Topics: Animals; Astrocytes; Disease Models, Animal; Ethylenediamines; Hyperalgesia; Male; Mice; Mice, Inbre | 2015 |
Gliogenic LTP spreads widely in nociceptive pathways.
Topics: Animals; Cerebrospinal Fluid; Hyperalgesia; Long-Term Potentiation; Male; Memory; Neuroglia; Neurona | 2016 |
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Excitato | 2017 |
DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls.
Topics: Adult; Amino Acid Sequence; Chronic Disease; DNA Mutational Analysis; Dopamine; Female; Fibromyalgia | 2009 |
Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel.
Topics: Amino Acid Sequence; Animals; Cell Line; Dogs; HeLa Cells; Humans; Hyperalgesia; Mice; Molecular Seq | 2010 |
The amino-terminal region of hemokinin-1 regulates the induction of thermal hyperalgesia in rats.
Topics: Amino Acid Sequence; Animals; Arginine; Hyperalgesia; Male; Neurotransmitter Agents; Rats; Rats, Spr | 2010 |
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain.
Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Disease Models, Animal; Freund's Adjuvant; Gene Expr | 2010 |
Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Ganglia, Spinal; Hyperalgesia; Male; N | 2011 |
Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine.
Topics: Analysis of Variance; Animals; Astrocytes; CD11b Antigen; Citrates; Disease Models, Animal; Enzyme I | 2011 |
N-Methyl-D-aspartate receptor modulators block hyperalgesia induced by acute low-dose morphine.
Topics: Analgesics; Animals; Dextromethorphan; Drug Interactions; Drug Therapy, Combination; Hyperalgesia; M | 2011 |
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
Topics: Analgesics; Animals; Behavior, Animal; D-Amino-Acid Oxidase; Formaldehyde; Hydrogen Peroxide; Hypera | 2012 |
[Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced peripheral neuropathy].
Topics: Animals; Antineoplastic Agents, Phytogenic; Ganglia, Spinal; Humans; Hyperalgesia; Paclitaxel; Perip | 2013 |
The spinal antinociceptive effect of nocistatin in neuropathic rats is blocked by D-serine.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Animals; Dose-Response Relationship, Drug; Glycine; Hyperalg | 2004 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area | 2005 |
Distinct effects of D-serine on spinal nociceptive responses in normal and carrageenan-injected rats.
Topics: Action Potentials; Animals; Carrageenan; Evoked Potentials, Somatosensory; Hyperalgesia; Injections; | 2006 |
Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat.
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Inflammation; | 2008 |
Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response | 1998 |
The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |
Substance P potentiates thermal hyperalgesia induced by intrathecal administration of D-serine in rats.
Topics: Animals; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; N-Methylaspartate; | 2001 |