formaldehyde has been researched along with Allodynia in 312 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sprague-Dawley rats were used to test the analgesic effect of pentazocine and neostigmine using the paw formalin pain model and the incision mechanical allodynia model." | 8.12 | Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats. ( Bai, X; Guo, J; Huang, H; Ouyang, H; Wu, S; Zhang, K, 2022) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 7.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in spite of moderate gastrointestinal side effects." | 7.85 | The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain. ( Guo, XJ; Liang, JC; Sun, Y; Tang, K; Wang, HY; Wang, Y; Wang, YT; Yin, JB; Zhao, YQ, 2017) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 7.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 7.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| "Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia." | 7.74 | Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008) |
| " As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated." | 7.73 | Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone. ( Andrade, SP; Araújo, F; Beraldo, H; Bertollo, CM; Coelho, MM; Costa, KA; Nascimento, EB; Oliveira, AC; Rocha, LT; Teixeira, LR, 2006) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 7.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| " Thus, the purpose of the present studies was to evaluate whether the neuronal nicotinic receptor agonist epibatidine possesses antihyperalgesic activity in the formalin model of facial pain." | 7.71 | Antihyperalgesic activity of epibatidine in the formalin model of facial pain. ( Clark, TM; Flores, CM; Gilbert, SD, 2001) |
| "The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system." | 7.70 | Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. ( Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ, 1998) |
| " (1) The therapeutic effects of the cannabinoid anandamide and the putative CB2 agonist palmitoylethanolamide were tested in a model of persistent visceral pain (turpentine inflammation of the urinary bladder)." | 7.70 | The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. ( Hasnie, FS; Jaggar, SI; Rice, AS; Sellaturay, S, 1998) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 7.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 7.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| "Drug effects on formalin-induced mechanical allodynia were evaluated for comparison." | 5.43 | Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016) |
| "Acute pain was determined using the hot plate test (thermal nociception) and the formalin test (inflammatory pain)." | 5.40 | The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice. ( Andersen, ML; Carlini, EL; Gama, VS; Molska, GR; Paula-Freire, LI, 2014) |
| "SA daily treatment significantly reduced mechanical allodynia in KOR and cannabinoid receptor 1 (CB1R) sensitive manner." | 5.38 | Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. ( Aviello, G; Boccella, S; Capasso, R; De Chiaro, M; de Novellis, V; Gatta, L; Guida, F; Izzo, AA; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Zjawiony, JK, 2012) |
| " Chronic administration of minocycline (40 and 80 mg/kg, i." | 5.37 | Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. ( Dua, K; Kulkarni, SK; Pabreja, K; Padi, SS; Sharma, S, 2011) |
| "NA-3,4-DCM, dosed systemically (intraperitoneally or per os), was capable of interfering with the development of mechanical hypernociception induced by intraplantar injection of carrageenan and complete Freund adjuvant in mice." | 5.36 | N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system. ( Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL, 2010) |
| "It had less effect on tactile allodynia (CCI)." | 5.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 5.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| "Lacosamide is a functionalized amino acid which was initially synthesized as an antiepileptic drug." | 5.33 | Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. ( Krause, E; Selve, N; Stöhr, T, 2006) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 5.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks." | 5.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| ") were tested against the acetic acid-induced nociception, carrageenan-induced acute inflammatory paw edema/hyperalgesia, formalin-induced nociception and carrageenan-induced pleurisy in Swiss mice." | 4.31 | Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves. ( Arena, AC; Cardoso, CAL; Euclides Silva-Filho, S; Heredia-Vieira, SC; Kassuya, CAL; Matos Leitão, M, 2023) |
| "The objective of this study is to test the hypothesis that citral modulates orofacial pain using two experimental models: formalin-induced hyperalgesia in the vibrissae area and during persistent temporomandibular hypernociception using Complete Freund's Adjuvant - CFA test." | 4.31 | Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats. ( Branco, LGS; Cárnio, EC; Emilio-Silva, MT; Garcia, FS; Hiruma-Lima, CA; Jesus, AA; Nascimento, GC; Santos, BM; Santos, WS; Solon, IG, 2023) |
| "Sprague-Dawley rats were used to test the analgesic effect of pentazocine and neostigmine using the paw formalin pain model and the incision mechanical allodynia model." | 4.12 | Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats. ( Bai, X; Guo, J; Huang, H; Ouyang, H; Wu, S; Zhang, K, 2022) |
| " Nociceptive response induced by formaldehyde and mechanical allodynia induced by chronic constriction injury (CCI) of the sciatic nerve or intraplantar (ipl) injection of complete Freund's adjuvant (CFA) were used as experimental models of pain." | 3.91 | The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain. ( Alves, RJ; Araújo, DP; Batista, CRA; Brito, AMS; Canhestro, WG; Coelho, MM; Coura, GME; de Fátima, Â; Dutra, MMGB; Godin, AM; Machado, RR; Matsui, TC; Melo, ISF, 2019) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 3.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in spite of moderate gastrointestinal side effects." | 3.85 | The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain. ( Guo, XJ; Liang, JC; Sun, Y; Tang, K; Wang, HY; Wang, Y; Wang, YT; Yin, JB; Zhao, YQ, 2017) |
| "To assess the interaction between bullatine A and morphine on antinociception in acute nociception and pain hypersensitivity states, with the exogenous synthetic dynorphin A as a comparison MATERIALS AND METHODS: Spinal nerve ligation-induced neuropathic rats and naïve mice were used for assessing the acute and chronic interactions of bullatine A/dynorphin A with morphine." | 3.85 | Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors. ( Chen, Y; Huang, Q; Li, XY; Sun, ML; Wang, YX, 2017) |
| "The mixture and the individual isolated cycloartanes significantly inhibited both phases of formalin-induced pain with percentage inhibition ranging from 13 to 78%." | 3.83 | Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities. ( Achounna, AS; Greffrath, W; Ngnokam, D; Nguelefack, TB; Piegang, BN; Tigoufack, IB; Treede, RD; Watcho, P, 2016) |
| "The role of oxytocin (OXT) in pain modulation has been suggested." | 3.83 | The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception. ( Condés-Lara, M; Godínez-Chaparro, B; González-Hernández, A; Manzano-García, A; Martínez-Lorenzana, G; Rodríguez-Jiménez, J; Rojas-Piloni, G, 2016) |
| " In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A." | 3.80 | Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. ( Bach-Rojecky, L; Drinovac, V; Lacković, Z, 2014) |
| " Third, formalin-induced depression of ICSS was reversed by morphine doses that did not significantly alter ICSS in saline-treated rats, suggesting that formalin effects on ICSS can be interpreted as an example of pain-related and analgesic-reversible depression of behavior." | 3.80 | Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats. ( Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC, 2014) |
| "Development of peripheral neuropathy, which can present as painful neuropathy or loss of sensation, sometimes limit the use of paclitaxel in the treatment of solid tumors such as breast cancer." | 3.80 | Paclitaxel-induced hyposensitivity to nociceptive chemical stimulation in mice can be prevented by treatment with minocycline. ( Masocha, W, 2014) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 3.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| "Ipsilateral, but not contralateral, pre-treatment (in μg/paw) with sumatriptan (10-300), methysergide (1-30) or dihydroergotamine (1-30) significantly prevented flinching behavior (at 1h) as well as secondary allodynia and hyperalgesia (at day 6) induced by formalin." | 3.79 | Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats. ( Argüelles, CF; Godínez-Chaparro, B; Granados-Soto, V; López-Santillán, FJ; Villalón, CM, 2013) |
| "To investigate the role of heme oxygenase and carbon monoxide (HO/CO) in the development of spontaneous pain and hyperalgesia of rats induced by formalin injection." | 3.79 | [The role of HO/CO in the spinal nociception transmission and hyperalgesia of rats induced by formalin]. ( Guo, LH; Li, HN; Li, QJ; Liu, L, 2013) |
| "The topical anti-inflammatory effects of SPRE were evaluated against acute models (croton oil-induced mouse ear edema and carrageenan-induced rat paw edema) and chronic model (complete Freund's adjuvant (CFA)-induced polyarthritis)." | 3.79 | Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo. ( Kaewnopparat, N; Mo, J; Nitiruangjaras, A; Panichayupakaranant, P; Reanmongkol, W, 2013) |
| ") with EEAO before the induction of nociceptive response by formalin, capsaicin and cinnamaldehyde, thermal heat hyperalgesia (hot plate test) and mechanical allodynia (traumatic sciatic nerve injury)." | 3.79 | Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice. ( Baggio, CH; Cipriani, TR; da Silva, CF; de Souza, LM; Hamm, LA; Nascimento, AM; Nomura, EC; Rodrigues, MR; Werner, MF, 2013) |
| "Spinal hydrogen peroxide is specifically and largely responsible for formalin-induced pain, and DAAO inhibitors produce analgesia by blocking spinal hydrogen peroxide production rather than interacting with spinal D-serine." | 3.78 | D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. ( Gong, N; Lu, JM; Wang, YC; Wang, YX, 2012) |
| "The antinociceptive and antiinflammatory activities of MEA were evaluated using the writhing, formalin, and tail-flick tests, carrageenan-induced paw edema and arachidonic acid-induced ear edema." | 3.77 | Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition. ( Barros, TA; Lucchese, AM; Nogueira, TM; Nonato, FR; Oliveira, CE; Santos, RR; Soares, MB; Villarreal, CF, 2011) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 3.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| " In an inflammatory pain model, Compound 5 suppressed the capsaicin-induced flinching behavior in a dose-dependent manner." | 3.77 | Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia. ( Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M, 2011) |
| "To develop a behavioral model in mice that is capable of mimicking some distinctive symptoms of human posttraumatic trigeminal neuropathic pain such as spontaneous pain, cold allodynia, and chemical÷inflammatory hyperalgesia, and to use this model to investigate the antinociceptive effects of clomipramine and tramadol, two drugs used for the treatment of neuropathic pain." | 3.77 | Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice. ( Alvarez, P; Brun, A; Constandil, L; Correa, A; Hernández, A; Labertrandie, A; Lopez, J; Pelissier, T, 2011) |
| "Maternal methamphetamine (MA) abuse during pregnancy has been proved to induce various impacts on the development of infant and child." | 3.76 | Prenatal exposure to methamphetamine alters the mechanical withdrawal threshold and tonic hyperalgesia in the offspring. ( Chen, JY; Chen, KB; Kuo, CT; Tao, PL; Wen, YR; Yeh, GC, 2010) |
| "A profound tachyphylaxis of the acute nocifensive flinching (pain) response to subcutaneous injection of endothelin-1 (ET-1) into the hind paw footpad is shown by the reduced response to a second injection." | 3.76 | Remarkably long-lasting tachyphylaxis of pain responses to ET-1: evidence against central nervous system involvement. ( Khodorova, A; Strichartz, GR, 2010) |
| "This study assesses the effects of peripheral or intrathecal pre-treatment or post-treatment with micro, delta, kappa and nociceptin/orphanin FQ (NOP) opioid receptor agonists (morphine, U-50488 [trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride], DADLE [D-Ala2-Leu5-enkephalin] and nociceptin, respectively) on formalin-induced secondary mechanical allodynia and hyperalgesia in rats." | 3.75 | Role of opioid receptors in the reduction of formalin-induced secondary allodynia and hyperalgesia in rats. ( Ambriz-Tututi, M; Araiza-Saldaña, CI; Caram-Salas, NL; Castañeda-Corral, G; Cruz, SL; Granados-Soto, V; Rocha-González, HI, 2009) |
| "In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception." | 3.74 | Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007) |
| "Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia." | 3.74 | Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| " As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated." | 3.73 | Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone. ( Andrade, SP; Araújo, F; Beraldo, H; Bertollo, CM; Coelho, MM; Costa, KA; Nascimento, EB; Oliveira, AC; Rocha, LT; Teixeira, LR, 2006) |
| " In this study, we investigated the effects of M58373 on substance P release from sensory neurons in vitro and pain behaviors/responses in rats, compared with mexiletine." | 3.73 | Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats. ( Akada, Y; Amano, K; Fukudome, Y; Itoh, M; Ogawa, S; Yamamoto, I; Yamasaki, F, 2006) |
| "5% formalin injection into the hind paw, acetic acid administration intraperitoneally or neuropathic pain testing consisting of mechanical allodynia (von Frey filament) and thermal hyperalgesia (Plantar test)." | 3.73 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "Bilateral lesions of the RMM with ibotenic acid, a soma-selective neurotoxin, were performed to study their effects on the spontaneous pain-related behaviors and hyperalgesia, which were determined by counting the number of flinching reflex per 5 min (1 h) and by measuring paw withdrawal thermal latency (PWTL) and mechanical threshold (PWMT) to radiant heat and von-Frey filaments to both hind paws in conscious rats, respectively." | 3.72 | Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: a comparative study between formalin test and bee venom test in the rat. ( Chen, HS; Chen, J; Li, MM; Shi, J, 2003) |
| ") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)." | 3.72 | Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 3.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| ") decreased thermal hyperalgesia observed in carrageenan-induced inflammatory hypersensitivity without affecting paw edema, abolished acetic acid-induced writhing activity in mice, and was shown to reduce mechanical allodynia and thermal hyperalgesia observed in a model of post-operative hypersensitivity and formalin-induced spontaneous pain." | 3.72 | Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. ( Decker, MW; Gauvin, DM; Honore, P; Lynch, JJ; Mikusa, JP; Wade, CL; Wilson, SG; Wismer, CT; Zhu, CZ, 2004) |
| " Thus, the purpose of the present studies was to evaluate whether the neuronal nicotinic receptor agonist epibatidine possesses antihyperalgesic activity in the formalin model of facial pain." | 3.71 | Antihyperalgesic activity of epibatidine in the formalin model of facial pain. ( Clark, TM; Flores, CM; Gilbert, SD, 2001) |
| "The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system." | 3.70 | Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. ( Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ, 1998) |
| " (1) The therapeutic effects of the cannabinoid anandamide and the putative CB2 agonist palmitoylethanolamide were tested in a model of persistent visceral pain (turpentine inflammation of the urinary bladder)." | 3.70 | The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. ( Hasnie, FS; Jaggar, SI; Rice, AS; Sellaturay, S, 1998) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 3.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 3.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| "Drugs that are clinically effective (mexiletine and desipramine) or ineffective (fluoxetine) in the treatment of human neuropathic pain were evaluated for efficacy in rat models involving central sensitization (i." | 3.69 | The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization. ( Hunter, JC; Jett, MF; McGuirk, J; Waligora, D, 1997) |
| "Chronic pain is a common disease that severely disrupts the quality of life." | 1.91 | Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice. ( Cao, W; Cheng, Y; Liu, M; Qin, X; Tong, J; Wu, X, 2023) |
| "EESE significantly reduced edema, cold allodynia and mechanical hyperalgesia responses induced by CFA." | 1.91 | Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves. ( Arena, AC; Bernal, LPT; Cardoso, CAL; Fraga, TL; Kassuya, CAL; Leitão, MM; Lencina, JDS; Radai, JAS; Silva-Filho, SE, 2023) |
| "Pain is one of the most frequent causes for patients to seek medical care." | 1.91 | Pramipexole inhibits formalin-induce acute and long-lasting mechanical hypersensitivity via NF-kB pathway in rats. ( Godínez-Chaparro, B; Mendoza-Pérez, F; Pérez-Ramos, J; Santamaria-Anzures, J, 2023) |
| "Heat and mechanical hyperalgesia were evaluated by radiant heat and von Frey filament tests, respectively." | 1.91 | Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin. ( Guo, J; Song, Y; Tang, J; Tang, Z; Yang, Y; Yu, G; Zhu, C, 2023) |
| "Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms." | 1.72 | Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2022) |
| "Cervical spinal cord contusion (CSC) paradigm was employed for induction of neuropathic pain." | 1.62 | Bupleurum falcatum L. alleviates nociceptive and neuropathic pain: Potential mechanisms of action. ( Ahmadimoghaddam, D; Izadidastenaei, Z; Mohammadi, S; Salehi, I; Zarei, M, 2021) |
| "FST-induced hyperalgesia in the hindpaw was prevented by repeated SL and SLX treatments." | 1.56 | Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats. ( Kakihara, Y; Nakatani, Y; Okamoto, K; Saeki, M; Shimizu, S; Taiyoji, M; Takagi, R; Yamamura, K, 2020) |
| "Moreover, opioid-induced hyperalgesia was observed after repeated administration of morphine, but not BN-9." | 1.56 | Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia. ( Chen, D; Fang, Q; Li, N; Niu, J; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R; Zhao, G; Zhu, H, 2020) |
| "The poncirin (30 mg/kg) treatment considerably inhibited the mechanical hyperalgesia and allodynia as well as thermal hyperalgesia and cold allodynia." | 1.51 | Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice. ( Afridi, R; Khalid, S; Khan, AU; Khan, S; Kim, YS; Rasheed, H; Shal, B; Shehzad, O; Ullah, MZ, 2019) |
| "Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia." | 1.51 | Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. ( Austin, JS; Coderre, TJ; Diamond, L; George, N; Macintyre, LC; Martin, LJ; Meluban, L; Mogil, JS; Sotocinal, SG; Tansley, SN, 2019) |
| "Intrathecal AIBP reverses established allodynia in mice in which pain states were induced by the chemotherapeutic cisplatin, intraplantar formalin, or intrathecal LPS, all of which are pro-nociceptive interventions known to be regulated by TLR4 signaling." | 1.48 | Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. ( An, EJ; Bae, YS; Choi, SH; Corr, M; Kim, J; Low, H; Miller, YI; Ramachandran, R; Schneider, DA; Sviridov, D; Woller, SA; Yaksh, TL, 2018) |
| "Furthermore, long-lasting bilateral hyperalgesia could be reversed by pharmacological inhibition of over-expressed spinal PKCγ; however, pretreating with intrathecal KIG31-1 showed no antinociceptive effects on short-term spontaneous pain behaviors." | 1.48 | Contribution of Spinal PKCγ Expression to Short- and Long-lasting Pain Behaviors in Formalin-induced Inflamed Mice. ( Chen, DS; Chen, GZ; Ding, T; Guo, XJ; Liang, JC; Tang, K; Wang, Y; Wu, HH; Yin, JB; Zhao, YQ, 2018) |
| "Paw oedema was inhibited at all times, and maximal inhibition was at the dose of 100 mg/kg at 2 h after carrageenan injection with 72±2% for EOP and 74±2% for EOS." | 1.46 | Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents. ( Argandoña, EJ; Arrigo, JD; Cardoso, CA; Correia, CA; Kassuya, CA; Maldonade, IR; Zuntini Viscardi, D, 2017) |
| "Insufficient sleep and chronic pain are public health epidemics." | 1.43 | Sleep Deprivation and Recovery Sleep Prior to a Noxious Inflammatory Insult Influence Characteristics and Duration of Pain. ( Vanini, G, 2016) |
| "Drug effects on formalin-induced mechanical allodynia were evaluated for comparison." | 1.43 | Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016) |
| "In vivo, IT LPS evoked tactile allodynia to a greater degree in male than female mice." | 1.43 | Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. ( Beaton, G; Chigbrow, M; Corr, M; Eddinger, KA; Isseroff, RR; Ravula, SB; Soulika, AM; Tucci, FC; Woller, SA; Yaksh, TL, 2016) |
| "Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians." | 1.43 | CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016) |
| "WB4-24 anti-allodynia was prevented by a microglial inhibitor, β-endorphin antiserum and a μ-opioid receptor antagonist." | 1.42 | The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia. ( Fan, H; Gong, N; Li, TF; Ma, AN; Wang, MW; Wang, YX; Wu, XY, 2015) |
| "In paclitaxel-treated mice, they did not attenuate heat hyperalgesia but N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl]oxy}-N-(2-thienylmethyl) benzamide hydrochloride salt (AMTB), a TRPM8 antagonist, reduced cold hyperalgesia and tactile allodynia by 31% (P<0." | 1.42 | Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. ( Filipek, B; Sałat, K, 2015) |
| "Acute pain was determined using the hot plate test (thermal nociception) and the formalin test (inflammatory pain)." | 1.40 | The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice. ( Andersen, ML; Carlini, EL; Gama, VS; Molska, GR; Paula-Freire, LI, 2014) |
| "NRG-1 inhibits neuropathic pain after SNI in a dose-dependent manner, while NRG-1 aggravates formalin-induced neuropathic pain." | 1.40 | Distinct roles of neuregulin in different models of neuropathic pain. ( Chen, X; Dai, DW; Deng, ZF; Lu, YM; Xu, Z; Yuan, L; Zhang, AJ; Zhang, PQ, 2014) |
| "CFA-induced hind paw mechanical allodynia (P < ." | 1.40 | Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. ( Grace, PM; Maier, SF; Strand, KA; Watkins, LR, 2014) |
| "Oxaliplatin induced mechanical allodynia, cold hyperalgesia and chemical/inflammatory supersensitivity at both hindpaw and vibrissal levels in mice and rats." | 1.40 | Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents. ( Bastian, G; Bourgoin, S; Hamon, M; Kayser, V; Michot, B, 2014) |
| "Since hyperalgesia remains after cessation of paclitaxel therapy and becomes chronic, we hypothesize that alteration in memory and the cognitive process of pain underlies hyperalgesia." | 1.40 | Paclitaxel-induced hyperalgesia modulates negative affective component of pain and NR1 receptor expression in the frontal cortex in rats. ( Akita, H; Noda, K; Ogata, M; Saji, M, 2014) |
| "The thermal hyperalgesia and mechanical allodynia induced by carrageenan injection and spared-nerve injury were significantly reduced in Adv/Ano1fl/fl mice." | 1.40 | Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. ( Cho, H; Jung, J; Lee, B; Oh, U; Yang, DJ; Yang, YD, 2014) |
| "However, orofacial heat and cold hyperalgesia, induced by carrageenan injected into the upper lip (50 µg/50 μl), was abolished by previous intraganglionar RTX treatment." | 1.40 | Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia. ( Chichorro, JG; Cruz, LS; Kopruszinski, CM, 2014) |
| "OVX rats developed thermal hyperalgesia in proximal and distal tail that was established 2 weeks after OVX and lasted the 7 weeks of the experiment." | 1.40 | Ovariectomy results in variable changes in nociception, mood and depression in adult female rats. ( Li, LH; Wang, ZC; Yu, J; Zhang, YQ, 2014) |
| "Modafinil was administered in the doses of 50, 100 or 200 mg/kg once in acute study and it showed significantly increased tail-flick latency (tfl) and paw-licking latency." | 1.40 | Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole. ( Bhattacharya, SK; Gupta, LK; Gupta, R, 2014) |
| "This LPS-induced hyperalgesia was accompanied by distinct recruitment of supra-spinal regions involved in analgesia as indicated by significantly attenuated Fos-protein induction in the rostral dorsal periaqueductal grey (DPAG) as well as rostral and caudal axes of the ventrolateral PAG (VLPAG)." | 1.40 | Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure. ( Beagley, KW; Campbell, EJ; Clifton, VL; Dayas, CV; Hodgson, DM; James, MH; Zouikr, I, 2014) |
| "Moreover, it produced secondary allodynia and hyperalgesia in the ipsilateral and contralateral paws for at least 6 days." | 1.40 | Evidence for the participation of Ca(2+)-activated chloride channels in formalin-induced acute and chronic nociception. ( García, G; Granados-Soto, V; Martínez-Rojas, VA; Murbartián, J; Rocha-González, HI, 2014) |
| "Pain is a complex experience that made up of sensory, emotional and cognitive dimensions, and the emotional factors have an important influence on intensity of pain perception." | 1.40 | Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats. ( Huang, Y; Lei, W; Lu, B; Sun, J; Xiao, C; Yao, J; Zhang, H, 2014) |
| "Heat hypoalgesia, but not mechanical hyperalgesia, was markedly attenuated by this treatment (P<0." | 1.39 | Endogenous descending facilitation and inhibition differ in control of formalin intramuscularly induced persistent muscle nociception. ( Lei, J; You, HJ, 2013) |
| "Secondary mechanical allodynia was assessed with von Frey filaments applied to the rat's hindpaw, and secondary thermal hyperalgesia was evaluated with the tail-immersion test." | 1.39 | Role of glutamate receptors in the dorsal reticular nucleus in formalin-induced secondary allodynia. ( Ambriz-Tututi, M; Drucker-Colín, AR; Millán-Aldaco, D; Palomero-Rivero, M; Ramirez-López, F, 2013) |
| "Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice." | 1.39 | Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae). ( Cechinel Filho, V; de Campos Buzzi, F; Klein-Júnior, LC; Moreira, J, 2013) |
| "Mechanical hyperalgesia was measured using the Randall-Selitto apparatus after injecting 5% formalin solution into the gastrocnemius muscle in mice treated with selective antagonists for B(1) or B(2) receptors." | 1.38 | Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways. ( Calixto, JB; Campos, R; Costa, R; da Silva, K; Meotti, FC; Paszcuk, AF, 2012) |
| "Ibuprofen was used as a reference compound in each test." | 1.38 | Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu. ( Brownell, L; Hodges, M; Jia, Q; Yimam, M, 2012) |
| "SA daily treatment significantly reduced mechanical allodynia in KOR and cannabinoid receptor 1 (CB1R) sensitive manner." | 1.38 | Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. ( Aviello, G; Boccella, S; Capasso, R; De Chiaro, M; de Novellis, V; Gatta, L; Guida, F; Izzo, AA; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Zjawiony, JK, 2012) |
| " Chronic administration of minocycline (40 and 80 mg/kg, i." | 1.37 | Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. ( Dua, K; Kulkarni, SK; Pabreja, K; Padi, SS; Sharma, S, 2011) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "Once secondary allodynia was established, treatment with chromaffin cells produced a significant reduction in the nociceptive behavior in both hind paws." | 1.37 | Chromaffin cell transplant in spinal cord reduces secondary allodynia induced by formalin in the rat. Role of opioid receptors and α₂-adrenoceptors. ( Ambriz-Tututi, M; Drucker-Colín, R; Sánchez-González, V, 2011) |
| "Evaluation of pain is a critical issue in human pathologies but also in animal experimentation." | 1.37 | Poincaré plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats. ( Charlet, A; Poisbeau, P; Rodeau, JL, 2011) |
| "Experiment 1 found hyperalgesia in female and male rats tested on the hot plate immediately after exposure to the elevated plus maze." | 1.37 | Environmentally induced antinociception and hyperalgesia in rats and mice. ( Cornélio, AM; Fugimoto, JS; Mendes-Gomes, J; Morgan, MM; Nunes-de-Souza, RL, 2011) |
| "NA-3,4-DCM, dosed systemically (intraperitoneally or per os), was capable of interfering with the development of mechanical hypernociception induced by intraplantar injection of carrageenan and complete Freund adjuvant in mice." | 1.36 | N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system. ( Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL, 2010) |
| "OB rats exhibited mechanical allodynia (von Frey test) but not thermal hyperalgesia (hot plate and tail-flick tests) when compared to sham-operated counterparts." | 1.36 | Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions. ( Burke, NN; Calpin, P; Finn, DP; Hayes, E; Kerr, DM; Moriarty, O; Roche, M, 2010) |
| "It had less effect on tactile allodynia (CCI)." | 1.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
| "LPS-induced hyperalgesia was exhibited in nociceptive behaviors induced by formalin s." | 1.35 | The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models. ( Choi, HW; Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Nam, JS; Park, SH; Seo, YJ; Suh, HW, 2008) |
| "EphrinB1-Fc-induced hyperalgesia is accompanied with the NMDA receptor-mediated increase of expression in peripheral and spinal phosphorylated mitogen-activated protein kinases (phospho-MAPKs) including p-p38, pERK and pJNK, and also is prevented or reversed by the inhibition of peripheral and spinal MAPKs." | 1.35 | Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice. ( Bao, Q; Cao, JL; Guan, XH; Ling, DY; Ruan, JP; Song, XJ; Yuan, Y; Zeng, YM; Zhang, LC, 2008) |
| "Mechanical hyperalgesia induced by Freund's Complete Adjuvant (CFA) was attenuated by 3-ASP administration to mice (maximal inhibition of 42+/-11%)." | 1.35 | Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| "It also produced thermal allodynia in response to cold (paw acetone test: 200% increase of allodynia score during week 3-5) and heat (42 degrees C tail immersion test: 15% decrease of withdrawal threshold, from week 2 onward)." | 1.35 | Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies. ( Bardin, L; Depoortère, R; Malfetes, N; Newman-Tancredi, A, 2009) |
| "This produced thermal and mechanical hyperalgesia in rats and mice and augmented mechanical and thermal hyperalgesia seen in the formalin inflammatory pain test." | 1.35 | Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons. ( Alier, KA; Andrade-Gordon, P; Cellars, L; Cenac, N; Chapman, K; Endicott, JA; Smith, PA; Stemkowski, PL; Vergnolle, N, 2008) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 1.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| "Lacosamide is a functionalized amino acid which was initially synthesized as an antiepileptic drug." | 1.33 | Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. ( Krause, E; Selve, N; Stöhr, T, 2006) |
| "NPB-deficient mice also exhibit hyperalgesia in response to inflammatory pain." | 1.33 | Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain. ( Beuckmann, CT; Garry, MG; Hammer, RE; Kelly, MA; Motoike, T; Richardson, JA; Sinton, CM; Williams, SC; Yanagisawa, M, 2005) |
| "IL-1beta-induced hyperalgesia was blocked by pretreatment with IL-1 receptor antagonist." | 1.33 | Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. ( Ahn, DK; Bae, YC; Chae, JM; Choi, HS; Kwon, OW; Kyung, HM; Park, HS; Youn, DH, 2005) |
| "Thermal hyperalgesia (drop of noxious heat threshold) and mechanical hyperalgesia induced by a mild heat injury (51 degrees C, 15s) was smaller in KO mice suggesting a pronociceptive role for TRPV1 receptor in burn injury." | 1.33 | Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. ( Almási, R; Bölcskei, K; Elekes, K; Helyes, Z; Németh, J; Pethő, G; Pintér, E; Sándor, K; Szabó, Á; Szolcsányi, J, 2005) |
| "When misoprostol was perfused in combination with the peripheral injection of formalin, we observed an increase of glutamate and an increase followed by a stronger decrease in GABA release." | 1.33 | Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia. ( Berrino, L; de Novellis, V; Maione, S; Marabese, I; Mariani, L; Oliva, P; Palazzo, E; Rossi, F; Scafuro, M; Siniscalco, D, 2006) |
| "Nitroglycerin-induced hyperalgesia can be detected as an increase in the nociceptive behavior evoked by the formalin test." | 1.33 | Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D, 2006) |
| "2 for (+)-AM1241 and L768242, respectively) of the dose-response curve." | 1.33 | CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms. ( Beltramo, M; Bernardini, N; Bertorelli, R; Campanella, M; Fredduzzi, S; Nicolussi, E; Reggiani, A, 2006) |
| "However, it did not influence thermal hyperalgesia in the zymosan-induced paw inflammation model indicating that GLAST is associated with spontaneous rather than inflammatory nociception." | 1.33 | The glutamate transporter GLAST is involved in spinal nociceptive processing. ( Coste, O; Ehnert, C; Geisslinger, G; Marian, C; Niederberger, E; Schmidtko, A, 2006) |
| " Apomorphine induced a biphasic dose-response relationship, low doses producing hyperalgesia and high doses inducing antinociception." | 1.33 | Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists. ( Constandil, L; Eschalier, A; Hernandez, A; Laurido, C; Pelissier, T, 2006) |
| "Nitroglycerin is a nitric oxide (NO) donor which activates nuclei involved in nociceptive transmission following systemic administration." | 1.32 | Nitroglycerin induces hyperalgesia in rats--a time-course study. ( Greco, R; Nappi, G; Sandrini, G; Sandrini, M; Tassorelli, C; Wang, D, 2003) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 1.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "However, they attenuated hyperalgesia in several nociceptive models associated with spinal sensitization including direct spinal activation (intrathecal substance P) and peripheral tissue inflammation (intraplantar formalin or carrageenan)." | 1.32 | Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. ( Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL, 2003) |
| "Preterm infants undergoing untreated, repeated painful procedures as part of their early experience are more likely to behave differently to pain as they mature than infants who were born at term and did not experience excessive exogenous pain." | 1.32 | The effects of exposure to repeated minor pain during the neonatal period on formalin pain behaviour and thermal withdrawal latencies. ( Johnston, CC; Walker, CD, 2003) |
| " Repeated intraperitoneal injections were, therefore, chosen as the dosing regimen." | 1.32 | Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. ( Geisslinger, G; Gühring, H; Kunz, S; Michaelis, M; Niederberger, E; Ritzeler, O; Schmidt, R; Tegeder, I, 2004) |
| "In addition, formalin-induced secondary hyperalgesia was locally prevented by pre-but not post-celecoxib treatment." | 1.32 | Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats. ( Avila, MN; da Motta, PG; Duarte, ID; Francischi, JN; Tatsuo, MA; Veiga, AP, 2004) |
| "Glycine is a candidate nociception inhibitory transmitter in specific brain regions, like for example the spinal cord, the thalamic nuclei and the periaqueductal gray matter." | 1.31 | Effects of persistent nociception on periaqueductal gray glycine release. ( Berrino, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Trabace, L, 2000) |
| "In conclusion, NO and PGE2 affect the hyperalgesia induced by excitatory amino acids." | 1.31 | The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats. ( Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD, 2000) |
| "PGE2 could induce mechanical allodynia in EP1(+/+), EP3(+/+) and EP3(-/-) mice, but not in EP1(-/-) mice." | 1.31 | Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. ( Ichikawa, A; Ito, S; Kobayashi, T; Minami, T; Nakano, H; Narumiya, S; Sugimoto, Y; Ushikubi, F, 2001) |
| "ketamine was effective only when given as a pretreatment." | 1.31 | Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model. ( Lee, IH; Lee, IO, 2001) |
| "As clinical pain is characterized by hyperalgesia, we evaluated the effects of NSAIDs with similar chemical structures but different selectivities for cyclo-oxygenase (COX)-1 and COX-2 in a new behavioural model of central hyperalgesia in rats." | 1.31 | Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. ( Bianchi, M; Panerai, AE, 2002) |
| "formalin-induced hyperalgesia, like illness-induced hyperalgesia, is dependent on the nucleus raphe magnus (NRM) but independent of the nucleus reticularis paragigantocellularis (NRPgc)." | 1.30 | Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. ( Maier, SF; Roemer, B; Watkins, LR; Wiertelak, EP, 1997) |
| "There was no corresponding thermal hyperalgesia adjacent to the injured sciatic nerve." | 1.30 | Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex. ( Mansikka, H; Pertovaara, A, 1997) |
| "However, this drug was unable to block hyperalgesia when already established." | 1.30 | Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol. ( Bianchi, M; Panerai, AE, 1997) |
| "or i." | 1.30 | Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. ( Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR, 1998) |
| "However, the HE did not affect the hyperalgesia induced by carrageenan or PGE2." | 1.30 | Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). ( Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA, 1998) |
| "Gabapentin displays efficacy against abnormal sensory processing in diabetic rats and may be of benefit for treating painful diabetic neuropathy." | 1.30 | Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. ( Calcutt, NA; Ceseña, RM, 1999) |
| "Touch evoked allodynia was observed after the injection of PGE1 2." | 1.30 | [The enhancement of formalin induced agitation behavior by intrathecal administration of prostaglandin E1]. ( Kuno, Y; Sato, E; Sato, I; Takano, M; Takano, Y, 1999) |
| "Cor inhibits formalin-induced hyperalgesia by the decrease of NOS-positive neurons in the spinal dorsal horn of rats." | 1.30 | Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia. ( Li, HD; Li, XC; Ruan, HZ; Zhao, BY; Zhou, HJ, 1999) |
| "Hyperalgesia is not mediated solely by circuitry intrinsic to the spinal cord, but rather involves activation of centrifugal pathways originating within the brain and descending to the spinal cord via pathway(s) outside of the dorsolateral funiculus." | 1.29 | Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade. ( Furness, LE; Horan, R; Maier, SF; Martinez, J; Watkins, LR; Wiertelak, EP, 1994) |
| "If this is the case, then hyperalgesia might be expected to be part of the constellation of adaptations that occur during sickness." | 1.29 | Acute and conditioned hyperalgesic responses to illness. ( Furness, L; Maier, SF; Mayr, T; Mooney-Heiberger, K; Smith, KP; Watkins, LR; Wicrtelak, EP, 1994) |
| "IL-1 beta also produces hyperalgesia and that this hyperalgesia (as well as most illness responses) is mediated via activation of subdiaphragmatic vagal afferents." | 1.29 | Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia. ( Brewer, MT; Goehler, LE; Maier, SF; Relton, J; Watkins, LR, 1995) |
| "ICI 222155 also prevented hyperalgesia in diabetic rats 21-60 min after formalin, whereas tolrestat suppressed activity in diabetic rats below controls and also suppressed activity in controls when given orally or intrathecally." | 1.29 | Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. ( Calcutt, NA; Li, L; Malmberg, AB; Yaksh, TL, 1995) |
| "An injection of dilute formalin induced hyperalgesia for about 2 h." | 1.29 | Antinociceptive effects of repeated systemic injections of calcitonin in formalin-induced hyperalgesic rats. ( Kuraishi, Y; Nagasawa, T; Umeno, H; Yamazaki, N, 1996) |
| "Conditions such as hyperalgesia can occur days or months after the noxious insult." | 1.29 | Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice. ( Goettl, VM; Larson, AA, 1996) |
| "Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks." | 1.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 47 (15.06) | 18.2507 |
| 2000's | 109 (34.94) | 29.6817 |
| 2010's | 130 (41.67) | 24.3611 |
| 2020's | 26 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hossaini, M | 1 |
| Duraku, LS | 1 |
| Kohli, SK | 1 |
| Jongen, JL | 1 |
| Holstege, JC | 1 |
| Abdalla, HB | 2 |
| Napimoga, MH | 3 |
| Teixeira, JM | 1 |
| Trindade-da-Silva, CA | 1 |
| Pieroni, VL | 1 |
| Dos Santos Araújo, FSM | 1 |
| Hammock, BD | 1 |
| Clemente-Napimoga, JT | 3 |
| Huang, H | 1 |
| Bai, X | 1 |
| Zhang, K | 1 |
| Guo, J | 2 |
| Wu, S | 1 |
| Ouyang, H | 1 |
| Abed, DZ | 2 |
| Jabbari, S | 2 |
| Zakaria, ZA | 2 |
| Mohammadi, S | 3 |
| Demartini, C | 1 |
| Greco, R | 5 |
| Francavilla, M | 1 |
| Zanaboni, AM | 1 |
| Tassorelli, C | 5 |
| de Matos Balsalobre, N | 1 |
| Dos Santos, E | 1 |
| Mariano Dos Santos, S | 1 |
| Arena, AC | 5 |
| Konkiewitz, EC | 1 |
| Ziff, EB | 1 |
| Nazari Formagio, AS | 1 |
| Leite Kassuya, CA | 1 |
| Liu, M | 4 |
| Cao, W | 3 |
| Qin, X | 3 |
| Tong, J | 3 |
| Wu, X | 3 |
| Cheng, Y | 3 |
| Bernal, LPT | 2 |
| Leitão, MM | 2 |
| Radai, JAS | 2 |
| Cardoso, CAL | 4 |
| Lencina, JDS | 2 |
| Fraga, TL | 2 |
| Silva-Filho, SE | 2 |
| Kassuya, CAL | 4 |
| Matos Leitão, M | 2 |
| Euclides Silva-Filho, S | 2 |
| Heredia-Vieira, SC | 2 |
| Santamaria-Anzures, J | 1 |
| Pérez-Ramos, J | 1 |
| Mendoza-Pérez, F | 1 |
| Godínez-Chaparro, B | 6 |
| Dembogurski, DSO | 1 |
| Bonfá, IS | 1 |
| Candeloro, L | 1 |
| Parisotto, EB | 1 |
| Toffoli Kadri, MC | 1 |
| Silva, DB | 1 |
| Santos, BM | 1 |
| Santos, WS | 1 |
| Solon, IG | 1 |
| Garcia, FS | 1 |
| Emilio-Silva, MT | 1 |
| Jesus, AA | 1 |
| Hiruma-Lima, CA | 2 |
| Nascimento, GC | 1 |
| Cárnio, EC | 1 |
| Branco, LGS | 1 |
| Zhu, C | 1 |
| Yang, Y | 2 |
| Song, Y | 1 |
| Yu, G | 1 |
| Tang, J | 1 |
| Tang, Z | 1 |
| García, G | 3 |
| Noriega-Navarro, R | 1 |
| Martínez-Rojas, VA | 4 |
| Gutiérrez-Lara, EJ | 1 |
| Oviedo, N | 1 |
| Murbartián, J | 4 |
| Shimizu, S | 1 |
| Nakatani, Y | 1 |
| Kakihara, Y | 1 |
| Taiyoji, M | 1 |
| Saeki, M | 1 |
| Takagi, R | 1 |
| Yamamura, K | 1 |
| Okamoto, K | 1 |
| Afridi, R | 1 |
| Khan, AU | 1 |
| Khalid, S | 1 |
| Shal, B | 1 |
| Rasheed, H | 1 |
| Ullah, MZ | 1 |
| Shehzad, O | 1 |
| Kim, YS | 1 |
| Khan, S | 1 |
| Batista, CRA | 1 |
| Godin, AM | 1 |
| Melo, ISF | 1 |
| Coura, GME | 1 |
| Matsui, TC | 1 |
| Dutra, MMGB | 1 |
| Brito, AMS | 1 |
| Canhestro, WG | 1 |
| Alves, RJ | 1 |
| Araújo, DP | 1 |
| de Fátima, Â | 1 |
| Machado, RR | 1 |
| Coelho, MM | 3 |
| Lee, JY | 1 |
| Lee, GJ | 1 |
| Lee, PR | 1 |
| Won, CH | 1 |
| Kim, D | 1 |
| Kang, Y | 1 |
| Oh, SB | 1 |
| Maegawa, H | 2 |
| Adachi, N | 2 |
| Hanamoto, H | 2 |
| Kudo, C | 2 |
| Niwa, H | 2 |
| Kumari, P | 1 |
| Kaur, S | 1 |
| Kaur, J | 1 |
| Bhatti, R | 1 |
| Singh, P | 1 |
| Rapacz, A | 1 |
| Rybka, S | 1 |
| Obniska, J | 1 |
| Jodłowska, A | 1 |
| Góra, M | 1 |
| Koczurkiewicz, P | 1 |
| Pękala, E | 1 |
| Siwek, A | 1 |
| Filipek, B | 2 |
| Wang, ZY | 1 |
| Han, QQ | 1 |
| Deng, MY | 1 |
| Zhao, MJ | 1 |
| Apryani, E | 1 |
| Shoaib, RM | 1 |
| Wei, DQ | 1 |
| Wang, YX | 5 |
| Wang, Y | 5 |
| Li, CM | 1 |
| Han, R | 1 |
| Wang, ZZ | 1 |
| Gao, YL | 1 |
| Zhu, XY | 1 |
| Yu, X | 1 |
| Du, GY | 1 |
| Wang, HB | 1 |
| Tian, JW | 1 |
| Fu, FH | 1 |
| Okuda-Ashitaka, E | 1 |
| Kakuchi, Y | 1 |
| Kakumoto, H | 1 |
| Yamanishi, S | 1 |
| Kamada, H | 1 |
| Yoshidu, T | 1 |
| Matsukawa, S | 1 |
| Ogura, N | 1 |
| Uto, S | 1 |
| Minami, T | 2 |
| Ito, S | 2 |
| Matsumoto, KI | 1 |
| Zhang, R | 1 |
| Xu, B | 1 |
| Zhang, Q | 1 |
| Chen, D | 2 |
| Zhang, M | 1 |
| Zhao, G | 1 |
| Xu, K | 1 |
| Xiao, J | 1 |
| Zhu, H | 1 |
| Niu, J | 1 |
| Li, N | 1 |
| Fang, Q | 1 |
| Ulker, E | 1 |
| Caillaud, M | 1 |
| Patel, T | 1 |
| White, A | 1 |
| Rashid, D | 1 |
| Alqasem, M | 1 |
| Lichtman, AH | 1 |
| Bryant, CD | 1 |
| Damaj, MI | 1 |
| Símaro, GV | 1 |
| Lemos, M | 1 |
| Mangabeira da Silva, JJ | 1 |
| Ribeiro, VP | 1 |
| Arruda, C | 1 |
| Schneider, AH | 1 |
| Wagner de Souza Wanderley, C | 1 |
| Carneiro, LJ | 1 |
| Mariano, RL | 1 |
| Ambrósio, SR | 1 |
| Faloni de Andrade, S | 1 |
| Banderó-Filho, VC | 1 |
| Sasse, A | 1 |
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| Andrade E Silva, ML | 1 |
| Bastos, JK | 1 |
| Ahmadimoghaddam, D | 1 |
| Zarei, M | 1 |
| Izadidastenaei, Z | 1 |
| Salehi, I | 1 |
| Takahara-Yamauchi, R | 1 |
| Ikemoto, H | 1 |
| Okumo, T | 1 |
| Sakhri, FZ | 1 |
| Horikawa, H | 1 |
| Nakamura, A | 1 |
| Sakaue, S | 1 |
| Kato, M | 1 |
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| Ran, C | 1 |
| Kamalani, GNA | 1 |
| Chen, X | 2 |
| Zhang, C | 1 |
| Li, Y | 1 |
| Wang, X | 2 |
| Fei, Y | 1 |
| Zhang, L | 2 |
| Zhao, YQ | 2 |
| Wang, HY | 1 |
| Yin, JB | 2 |
| Sun, Y | 1 |
| Liang, JC | 2 |
| Guo, XJ | 2 |
| Tang, K | 2 |
| Wang, YT | 1 |
| Sałat, K | 2 |
| Kołaczkowski, M | 1 |
| Furgała, A | 1 |
| Rojek, A | 1 |
| Śniecikowska, J | 1 |
| Varney, MA | 1 |
| Newman-Tancredi, A | 2 |
| Cervantes-Durán, C | 3 |
| Ortega-Varela, LF | 1 |
| Godínez-Hernández, D | 1 |
| Granados-Soto, V | 12 |
| Gauthereau-Torres, MY | 1 |
| Zanfirescu, A | 1 |
| Cristea, AN | 1 |
| Nitulescu, GM | 1 |
| Velescu, BS | 1 |
| Gradinaru, D | 1 |
| Sikandar, S | 1 |
| Minett, MS | 1 |
| Millet, Q | 1 |
| Santana-Varela, S | 1 |
| Lau, J | 1 |
| Wood, JN | 1 |
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| Woller, SA | 2 |
| Choi, SH | 1 |
| An, EJ | 1 |
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| Yaksh, TL | 12 |
| Miller, YI | 1 |
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| da Rocha, JT | 1 |
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| Ambrosino, G | 1 |
| Di Marzo, V | 1 |
| Kowaluk, EA | 1 |
| Schweitzer, E | 1 |
| Jiang, M | 1 |
| Bhagwat, SS | 1 |
| McKie, J | 1 |
| Cox, BF | 1 |
| Polakowski, J | 1 |
| Reinhart, G | 1 |
| Williams, M | 1 |
| Maixner, W | 1 |
| Gilbert, SD | 1 |
| Clark, TM | 1 |
| Flores, CM | 1 |
| Saegusa, H | 1 |
| Kurihara, T | 1 |
| Zong, S | 1 |
| Kazuno , A | 1 |
| Matsuda, Y | 1 |
| Nonaka, T | 1 |
| Han, W | 1 |
| Toriyama, H | 1 |
| Tanabe, T | 1 |
| Nakano, H | 1 |
| Kobayashi, T | 1 |
| Sugimoto, Y | 1 |
| Ushikubi, F | 1 |
| Ichikawa, A | 1 |
| Sorkin, LS | 1 |
| Doom, CM | 1 |
| Lee, IH | 1 |
| Souza, AL | 1 |
| Moreira, FA | 1 |
| Almeida, KR | 1 |
| Della Seta, D | 1 |
| Rendo, C | 1 |
| Scaramuzzino, A | 1 |
| Farabollini, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oxidative Stress and Surgical Recovery[NCT04732000] | Phase 2 | 21 participants (Actual) | Interventional | 2021-07-01 | Active, not recruiting | ||
| Iontophoresis Effects on Senses[NCT02487914] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors[NCT05684367] | 24 participants (Anticipated) | Interventional | 2023-11-29 | Recruiting | |||
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| Is The Pre-Emptive Administration Of Ketamine A Significant Adjunction To Intravenous Morphine Analgesia For Controlling Post-Operative Pain? A Randomized, Double Blind, Placebo Controlled Clinical Trial.[NCT03415191] | 75 participants (Actual) | Interventional | 2012-01-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
1 trial available for formaldehyde and Allodynia
| Article | Year |
|---|---|
The effect of pentoxifiline on post-injury hyperalgesia in rats and postoperative pain in patients.
Topics: Adult; Animals; Cholecystectomy; Formaldehyde; Humans; Hyperalgesia; Injections, Intraperitoneal; In | 2000 |
311 other studies available for formaldehyde and Allodynia
| Article | Year |
|---|---|
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund' | 2014 |
Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cytokines; Epoxide Hydrolases; Formaldehyde; Hyperalg | 2022 |
Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.
Topics: Analgesics; Animals; Atropine Derivatives; Clonidine; Formaldehyde; Humans; Hyperalgesia; Naloxone; | 2022 |
Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil.
Topics: Analgesics; Animals; Cyclic GMP; Dopamine; Formaldehyde; Hyperalgesia; Oils, Volatile; Pain Measurem | 2022 |
Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin | 2022 |
Potential anti-arthritic and analgesic properties of essential oil and viridiflorol obtained from Allophylus edulis leaves in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dexamethasone; Dihydroxyphenylalanine; D | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Pramipexole inhibits formalin-induce acute and long-lasting mechanical hypersensitivity via NF-kB pathway in rats.
Topics: Animals; Formaldehyde; Hyperalgesia; NF-kappa B; Pain; Pramipexole; Quality of Life; Rats; Rats, Wis | 2023 |
Infusion from Miconia albicans (Melastomataceae) leaves exhibits anti-inflammatory and anti-hyperalgesic activities without toxicity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Formaldehyde; Hyperalgesi | 2023 |
Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats.
Topics: Analgesics; Animals; Facial Pain; Formaldehyde; Hyperalgesia; Inflammation; Rats | 2023 |
Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Chronic Pain; Formaldehyde; Ga | 2023 |
Effects of Chaerophyllum macropodum Boiss. leaves essential oil in inflammatory and neuropathic pain: uncovering the possible mechanism of action.
Topics: Analgesics; Analgesics, Opioid; Formaldehyde; Humans; Hyperalgesia; Neuralgia; Oils, Volatile; Plant | 2023 |
Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain.
Topics: Animals; Disease Models, Animal; Down-Regulation; Female; Formaldehyde; Ganglia, Spinal; Humans; Hyp | 2019 |
Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats.
Topics: Animals; Behavior, Animal; Ethanol; Fermentation; Formaldehyde; Hindlimb; Hyperalgesia; Immunohistoc | 2020 |
Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Pain; Disease Mo | 2019 |
The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inflamma | 2019 |
The analgesic effect of refeeding on acute and chronic inflammatory pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Eating; Food Deprivat | 2019 |
Bilateral Parkinson's disease model rats exhibit hyperalgesia to subcutaneous formalin administration into the vibrissa pad.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Formaldehyde; Hyperalgesia; Immunohistochemistry; | 2019 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In | 2020 |
Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain.
Topics: Acute Pain; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Formaldehyde; Hep G2 Cells | 2020 |
Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors.
Topics: Aconitine; Acrylamides; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; beta-Endorphin | 2020 |
PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala.
Topics: Amygdala; Analgesics; Animals; Behavior, Animal; Comorbidity; Disease Models, Animal; Formaldehyde; | 2020 |
Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome.
Topics: Analgesics; Animals; Ehlers-Danlos Syndrome; Formaldehyde; Hyperalgesia; Male; Mice, Inbred C57BL; P | 2020 |
Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Drug Tolerance; Fascia; Formaldehyde; Hot Temperature; Hyp | 2020 |
C57BL/6 substrain differences in formalin-induced pain-like behavioral responses.
Topics: Animals; Behavior, Animal; Disinfectants; Female; Formaldehyde; Hyperalgesia; Inflammation; Male; Mi | 2020 |
Antinociceptive and anti-inflammatory activities of Copaifera pubiflora Benth oleoresin and its major metabolite ent-hardwickiic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Behavior, Anima | 2021 |
Bupleurum falcatum L. alleviates nociceptive and neuropathic pain: Potential mechanisms of action.
Topics: Animals; Arginine; Bupleurum; Cyclic GMP; Formaldehyde; Hyperalgesia; Iran; Male; Medicine, Traditio | 2021 |
Analgesic effect of voluntary exercise in a rat model of persistent pain via suppression of microglial activation in the spinal cord.
Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Chronic Pain; Disease Mo | 2021 |
TREK-1 potassium channels participate in acute and long-lasting nociceptive hypersensitivity induced by formalin in rats.
Topics: Animals; Disease Models, Animal; Disinfectants; Female; Formaldehyde; Ganglia, Spinal; Hyperalgesia; | 2021 |
Modality-Specific Modulation of Temperature Representations in the Spinal Cord after Injury.
Topics: Animals; Antineoplastic Agents; Calcium; Formaldehyde; Hyperalgesia; Mice; Mice, Transgenic; Oxalipl | 2021 |
Involvement of neurokinin 1 receptor within the cerebrospinal fluid‑contacting nucleus in visceral pain.
Topics: Animals; Cell Nucleus; Cerebrospinal Fluid; Formaldehyde; Hyperalgesia; Male; Neurokinin-1 Receptor | 2017 |
The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain.
Topics: Analgesics; Animals; Celecoxib; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; | 2017 |
Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT
Topics: Analgesics; Animals; Antineoplastic Agents; Cyclohexanes; Diabetic Neuropathies; Disease Models, Ani | 2017 |
Toluene exposure enhances acute and chronic formalin-induced nociception in rats: Participation of 5-HT
Topics: Animals; Disease Models, Animal; Disinfectants; Dose-Response Relationship, Drug; Female; Formaldehy | 2017 |
Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Adm | 2017 |
Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carrageenan; Chronic Pain; Disease Models, Animal; Femal | 2018 |
Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States.
Topics: Animals; Carrier Proteins; Cholesterol; Cisplatin; Cytokines; Formaldehyde; Hyperalgesia; Inflammati | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehy | 2018 |
Contribution of Spinal PKCγ Expression to Short- and Long-lasting Pain Behaviors in Formalin-induced Inflamed Mice.
Topics: Animals; Behavior, Animal; China; Chronic Pain; Formaldehyde; Hyperalgesia; Male; Mice; Pain Measure | 2018 |
Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldeh | 2019 |
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cystathionine beta-Synthase; Diabetes Mellitus, Experi | 2019 |
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Anim | 2019 |
Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.
Topics: Acetic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Formald | 2019 |
Microneedles Coated with Tramadol Exhibit Antinociceptive Effect in a Rat Model of Temporomandibular Hypernociception.
Topics: Analgesics, Opioid; Animals; Cytokines; Drug Delivery Systems; Formaldehyde; Hyperalgesia; Injection | 2019 |
Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemokines; Edema; Formaldehyde; Glycyrrhizic Acid; H | 2019 |
Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.
Topics: Amides; Animals; Formaldehyde; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Kno | 2019 |
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarat | 2013 |
Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
Topics: Acute Pain; Animals; Biphenyl Compounds; Chronic Pain; Dihydroergotamine; Disease Models, Animal; Dr | 2013 |
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications; | 2013 |
Activation of microglial cells in the trigeminal subnucleus caudalis evoked by inflammatory stimulation of the oral mucosa.
Topics: Animals; Calcium-Binding Proteins; Formaldehyde; Hyperalgesia; Inflammation; Male; Microfilament Pro | 2013 |
[The role of HO/CO in the spinal nociception transmission and hyperalgesia of rats induced by formalin].
Topics: Animals; Carbon Monoxide; Formaldehyde; Heme Oxygenase (Decyclizing); Hemin; Hyperalgesia; Male; Noc | 2013 |
Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo.
Topics: Administration, Topical; Analgesics; Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis; Carr | 2013 |
Endogenous descending facilitation and inhibition differ in control of formalin intramuscularly induced persistent muscle nociception.
Topics: Animals; Formaldehyde; Hyperalgesia; Injections, Intramuscular; Male; Motor Activity; Muscle, Skelet | 2013 |
Diphenyl diselenide reduces mechanical and thermal nociceptive behavioral responses after unilateral intrastriatal administration of 6-hydroxydopamine in rats.
Topics: Administration, Oral; Animals; Benzene Derivatives; Corpus Striatum; Formaldehyde; Hot Temperature; | 2013 |
Role of glutamate receptors in the dorsal reticular nucleus in formalin-induced secondary allodynia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonist | 2013 |
Simvastatin attenuates formalin-induced nociceptive behaviors by inhibiting microglial RhoA and p38 MAPK activation.
Topics: Animals; Behavior, Animal; Formaldehyde; Hyperalgesia; Male; Microglia; Nociception; p38 Mitogen-Act | 2013 |
Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice.
Topics: Acrolein; Analgesics; Animals; Asteraceae; Capsaicin; Ethanol; Flowers; Formaldehyde; Hot Temperatur | 2013 |
The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice.
Topics: Acute Pain; Administration, Oral; Analgesics; Animals; Cannabis; Chronic Pain; Formaldehyde; Hot Tem | 2014 |
Distinct roles of neuregulin in different models of neuropathic pain.
Topics: Animals; Formaldehyde; Hyperalgesia; Male; Neuralgia; Neuregulin-1; Rats; Receptor, ErbB-2 | 2014 |
Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models.
Topics: Animals; Carrageenan; Disease Models, Animal; Formaldehyde; Hyperalgesia; Inflammation; Male; Pain; | 2014 |
Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain.
Topics: Animals; Formaldehyde; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Lumbosacral Region; | 2014 |
Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Formaldehyde; Hyperalgesia; Membrane Glycoproteins; M | 2014 |
Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.
Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Analgesics; Animals; Cold Temperature; Cyclohexaneca | 2014 |
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
Topics: Animals; Bicuculline; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Routes; | 2014 |
Paclitaxel-induced hyperalgesia modulates negative affective component of pain and NR1 receptor expression in the frontal cortex in rats.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Conditioning, Operant; Formaldehyd | 2014 |
Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity.
Topics: Animals; Anoctamin-1; Bradykinin; Chloride Channels; Formaldehyde; Gene Expression Regulation; Hyper | 2014 |
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity.
Topics: Animals; Butadienes; Cyclin-Dependent Kinase 5; Enzyme Activation; Fixatives; Formaldehyde; Hyperalg | 2014 |
Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion.
Topics: Animals; Axons; Bradykinin; Caspase 6; Caspase Inhibitors; Cells, Cultured; Formaldehyde; Hyperalges | 2014 |
Activation of peripheral KCNQ channels attenuates inflammatory pain.
Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stim | 2014 |
Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia.
Topics: Animals; Capsaicin; Carrageenan; Cold Temperature; Disease Models, Animal; Diterpenes; Facial Pain; | 2014 |
Ovariectomy results in variable changes in nociception, mood and depression in adult female rats.
Topics: Affect; Animals; Behavior, Animal; Depression; Fear; Female; Formaldehyde; Hyperalgesia; Maze Learni | 2014 |
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Form | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Aci | 2014 |
Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure.
Topics: Analgesia; Animals; Animals, Newborn; Female; Formaldehyde; Hyperalgesia; Lipopolysaccharides; Pain; | 2014 |
Evidence for the participation of Ca(2+)-activated chloride channels in formalin-induced acute and chronic nociception.
Topics: Animals; Anoctamin-1; Chloride Channels; Female; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Niflum | 2014 |
Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats.
Topics: Analgesics; Animals; Avoidance Learning; Cell-Penetrating Peptides; Conditioning, Psychological; Dis | 2014 |
Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.
Topics: Acetaldehyde; Acute Pain; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Be | 2014 |
The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; beta-Endorphin; Carrageenan; Cells, Cultured; Cyclobu | 2015 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyd | 2014 |
Epidural dexamethasone decreased inflammatory hyperalgesia and spinal cPLA₂ expression in a rat formalin test.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Formaldehyde; Group IV Phospholipases A2; Hyperalg | 2014 |
Paclitaxel-induced hyposensitivity to nociceptive chemical stimulation in mice can be prevented by treatment with minocycline.
Topics: Animals; Breast Neoplasms; Female; Formaldehyde; Humans; Hyperalgesia; Mice; Minocycline; Nociceptio | 2014 |
Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Blotting, Western; Capsaicin; Cnidarian Venoms; Disea | 2014 |
Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw.
Topics: Animals; Autoantigens; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Subcutaneous; Male; Mice; M | 2015 |
Characterization of nociceptive response to chemical, mechanical, and thermal stimuli in adolescent rats with neonatal dopamine depletion.
Topics: Animals; Animals, Newborn; Brain Stem; Dopamine; Dopamine Agents; Formaldehyde; Hot Temperature; Hyp | 2015 |
Neural mechanism underlying hyperalgesic response to orofacial pain in Parkinson's disease model rats.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Facial Pain; Formaldehyde; Hyperalgesia; Male; Oxi | 2015 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; | 2015 |
The major histocompatibility complex genes impact pain response in DA and DA.1U rats.
Topics: Animals; Animals, Congenic; Disease Models, Animal; Disinfectants; Female; Formaldehyde; Gene Expres | 2015 |
Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.
Topics: Analgesics; Animals; Anthracenes; Cisplatin; Drug Tolerance; Fentanyl; Formaldehyde; Hyperalgesia; H | 2015 |
Effects of acute and sustained pain manipulations on performance in a visual-signal detection task of attention in rats.
Topics: Animals; Attention; Behavior, Animal; Edema; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Lactic A | 2015 |
Sleep Deprivation and Recovery Sleep Prior to a Noxious Inflammatory Insult Influence Characteristics and Duration of Pain.
Topics: Animals; Chronic Pain; Formaldehyde; Hyperalgesia; Inflammation; Male; Pain Measurement; Rats; Rats, | 2016 |
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expr | 2015 |
EphrinB-EphB signaling regulates spinal pain processing via PKCγ.
Topics: Analysis of Variance; Animals; Bone Neoplasms; Disease Models, Animal; Ephrin-B2; Formaldehyde; Hype | 2015 |
Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Bupropion; Depression; Disease Models, Animal; Dose-Respons | 2016 |
Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice.
Topics: Acetic Acid; Amides; Analgesics; Anilides; Animals; Butyric Acid; Formaldehyde; Hot Temperature; Hyp | 2016 |
Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain.
Topics: Animals; Chromatography, Liquid; Chronic Pain; Disease Models, Animal; Formaldehyde; Hyperalgesia; M | 2016 |
Role of spinal 5-HT2 receptors subtypes in formalin-induced long-lasting hypersensitivity.
Topics: Animals; Female; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Ketanserin; Pain Measurement; Pyrimidi | 2016 |
Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities.
Topics: Analgesics; Animals; Antioxidants; Female; Formaldehyde; Hyperalgesia; Inflammation; Liver; Male; Ma | 2016 |
Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.
Topics: Animals; Behavior, Animal; Chronic Pain; Disease Models, Animal; Disinfectants; Female; Formaldehyde | 2016 |
Possible Involvement of the Rat Hypothalamo-Neurohypophysial/-Spinal Oxytocinergic Pathways in Acute Nociceptive Responses.
Topics: Animals; Corticotropin-Releasing Hormone; Formaldehyde; Hyperalgesia; Hypothalamus; Injections, Spin | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heter | 2016 |
The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception.
Topics: Animals; Electric Stimulation; Formaldehyde; Hyperalgesia; Male; Methiothepin; Nociception; Oxytocin | 2016 |
Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice.
Topics: Analysis of Variance; Animals; Corticosterone; Disease Models, Animal; Female; Fixatives; Formaldehy | 2016 |
Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia.
Topics: Animals; Chondroitin Sulfates; Formaldehyde; Hyperalgesia; Male; Mice; Neurons; p38 Mitogen-Activate | 2016 |
CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice.
Topics: Anemia, Sickle Cell; Anesthetics, Local; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein | 2016 |
Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor.
Topics: Analgesics; Animals; Berberine Alkaloids; Chronic Pain; Ethylenediamines; Formaldehyde; Gene Express | 2016 |
Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors.
Topics: Alkaloids; Analgesics; Animals; Behavior, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug | 2017 |
The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Face; Formaldehyde; Hindlimb; | 2017 |
Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chemotaxis, Leukocyte; Cold Temperature; | 2017 |
Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia.
Topics: Animals; Behavior, Animal; Blotting, Western; Cytosol; Down-Regulation; Formaldehyde; Hot Temperatur | 2008 |
Effects of norketamine enantiomers in rodent models of persistent pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Dr | 2008 |
The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Injecti | 2008 |
Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Estro | 2008 |
Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice.
Topics: Animals; Anthracenes; Butadienes; Dizocilpine Maleate; Ephrin-B1; Foot; Formaldehyde; Hot Temperatur | 2008 |
Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Blood-Brain Barrier; Carrageenan; Drug Evaluation, P | 2008 |
Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia.
Topics: Adrenergic Agents; Animals; Basal Ganglia; Denervation; Dopamine; Formaldehyde; Hyperalgesia; Image | 2008 |
Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test.
Topics: Acid Sensing Ion Channels; Animals; Behavior, Animal; Formaldehyde; Freund's Adjuvant; Hot Temperatu | 2009 |
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
Topics: Analysis of Variance; Anesthetics; Animals; Arginine; Diazepam; Disease Models, Animal; Dose-Respons | 2009 |
Impairment of VGLUT2 but not VGLUT1 signaling reduces neuropathy-induced hypersensitivity.
Topics: Animals; Ataxia; Behavior, Animal; Carrageenan; Constriction, Pathologic; Formaldehyde; Hot Temperat | 2009 |
Activation of NMDA receptor is associated with up-regulation of COX-2 expression in the spinal dorsal horn during nociceptive inputs in rats.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2009 |
B vitamins alleviate indices of neuropathic pain in diabetic rats.
Topics: Aldehydes; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Resp | 2009 |
Roles of endothelin ETA and ETB receptors in nociception and chemical, thermal and mechanical hyperalgesia induced by endothelin-1 in the rat hindpaw.
Topics: Animals; Dose-Response Relationship, Drug; Endothelin-1; Formaldehyde; Hindlimb; Hyperalgesia; Male; | 2009 |
Down-regulation of K+ -Cl- co-transporter 2 in mouse medullary dorsal horn contributes to the formalin-induced inflammatory orofacial pain.
Topics: Animals; Down-Regulation; Facial Pain; Formaldehyde; Hyperalgesia; K Cl- Cotransporters; Male; Mice; | 2009 |
Aqueous extract of Asiasari radix inhibits formalin-induced hyperalgesia via NMDA receptors.
Topics: Animals; Aristolochiaceae; Formaldehyde; Hyperalgesia; Male; Mice; Plant Extracts; Receptors, N-Meth | 2009 |
Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice.
Topics: Analgesics; Animals; Bradykinin; Capsaicin; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hot Temp | 2009 |
Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice.
Topics: Analysis of Variance; Animals; Arginine; Drug Tolerance; Formaldehyde; Hyperalgesia; Injections, Spi | 2009 |
Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies.
Topics: Animals; Body Weight; Chronic Disease; Cold Temperature; Disease Models, Animal; Formaldehyde; Hot T | 2009 |
Role of opioid receptors in the reduction of formalin-induced secondary allodynia and hyperalgesia in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2009 |
Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats.
Topics: Analysis of Variance; Animals; CD47 Antigen; Cells, Cultured; Disease Models, Animal; Dose-Response | 2010 |
N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.
Topics: Administration, Oral; Analgesics; Animals; Antipyrine; Behavior, Animal; Carrageenan; Chronic Diseas | 2010 |
Prenatal exposure to methamphetamine alters the mechanical withdrawal threshold and tonic hyperalgesia in the offspring.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Birth Weight; Body Temperature; Body W | 2010 |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Behavior, An | 2011 |
Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
Topics: Amygdala; Analysis of Variance; Animals; Butadienes; Enzyme Inhibitors; Excitatory Amino Acid Antago | 2010 |
Remarkably long-lasting tachyphylaxis of pain responses to ET-1: evidence against central nervous system involvement.
Topics: Anesthetics; Animals; Central Nervous System; Endothelin A Receptor Antagonists; Endothelin-1; Foot; | 2010 |
Analgesic effects of the ethanolic extract from Magnolia ovata (Magnoliaceae) trunk bark and of N-acetylxylopine, a semi-synthetic analogue of xylopine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aporphines; Carrageenan; Disease Models, | 2011 |
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Carragee | 2010 |
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
Topics: Amygdala; Animals; Behavior, Animal; Dipeptides; Disease Models, Animal; Excitatory Postsynaptic Pot | 2010 |
Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions.
Topics: Analysis of Variance; Animals; Area Under Curve; Biogenic Monoamines; Brain; Chromatography, High Pr | 2010 |
Inter-strain differences of serotonergic inhibitory pain control in inbred mice.
Topics: Animals; Chronic Disease; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Infla | 2010 |
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Fixatives; Formaldehyde; Ganglia, Spinal; Ge | 2010 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic | 2011 |
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat.
Topics: Acetanilides; Analysis of Variance; Animals; Ankyrins; Calcium Channels; Capsaicin; Cholecystokinin; | 2011 |
Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia.
Topics: Animals; Anti-Asthmatic Agents; Area Under Curve; Cromolyn Sodium; Disease Models, Animal; Dose-Resp | 2011 |
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.
Topics: Androstadienes; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2011 |
Formalin-induced long-term secondary allodynia and hyperalgesia are maintained by descending facilitation.
Topics: Animals; Dynorphins; Female; Formaldehyde; Hyperalgesia; Immune Sera; Medulla Oblongata; Rats; Rats, | 2011 |
Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Biomarkers; Blood Glucose; Body W | 2011 |
Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain.
Topics: Acute Disease; Anesthesia; Animals; Behavior, Animal; Chronic Disease; Cyclic P-Oxides; Disease Mode | 2011 |
Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep.
Topics: Aminobutyrates; Animals; Behavior, Animal; Benzhydryl Compounds; Disease Models, Animal; Dose-Respon | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antag | 2011 |
Chromaffin cell transplant in spinal cord reduces secondary allodynia induced by formalin in the rat. Role of opioid receptors and α₂-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cell Survival; Chromaffin Cells; Female; Formaldeh | 2011 |
Poincaré plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats.
Topics: Algorithms; Animals; Body Temperature; Carrageenan; Disease Models, Animal; Formaldehyde; Heart Rate | 2011 |
Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Cell Death; Cerebrovascular Circula | 2011 |
Environmentally induced antinociception and hyperalgesia in rats and mice.
Topics: Analysis of Variance; Animals; Environment; Female; Formaldehyde; Hyperalgesia; Male; Maze Learning; | 2011 |
Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Topics: Acoustic Stimulation; Animals; Conditioning, Classical; Cues; Disease Models, Animal; Fear; Formalde | 2012 |
The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic.
Topics: Alkynes; Analgesics; Animals; Behavior, Animal; Benzene; Constriction, Pathologic; Feasibility Studi | 2011 |
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
Topics: Analgesics; Animals; Behavior, Animal; D-Amino-Acid Oxidase; Formaldehyde; Hydrogen Peroxide; Hypera | 2012 |
Knockdown of the tachykinin neurokinin 1 receptor by intrathecal administration of small interfering RNA in rats.
Topics: Animals; Base Sequence; Behavior, Animal; Carrageenan; Formaldehyde; Gene Expression Regulation; Gen | 2011 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde | 2011 |
Pharmacological characteristics of endokinin C/D-derived peptides in nociceptive and inflammatory processing in rats.
Topics: Amino Acid Sequence; Amino Acids; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; C | 2011 |
Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Behavior, Animal; Drugs, Chinese Herbal; Formaldehyde; | 2011 |
Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways.
Topics: Animals; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Cytokines; Enzyme I | 2012 |
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice.
Topics: Acetone; Analgesics, Opioid; Animals; Capsaicin; Clomipramine; Disease Models, Animal; Formaldehyde; | 2011 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxet | 2012 |
Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Chronic Pain; Cold Temperature; Complex R | 2012 |
Influence of age on pain sensitivity in response to paw pressure and formalin injection in rats: a role of nitric oxide.
Topics: Aging; Animals; Brain; Foot; Formaldehyde; Hyperalgesia; Male; Nitric Oxide; Pain Threshold; Pressur | 2012 |
Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT₄, 5-HT₆ and 5-HT₇ receptors.
Topics: 5,7-Dihydroxytryptamine; Animals; Female; Formaldehyde; Hyperalgesia; Indoles; Injections, Spinal; p | 2012 |
Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechin; Edema; Flavonoids; For | 2012 |
Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
Topics: Animals; Anti-Inflammatory Agents; Diterpenes, Clerodane; Formaldehyde; Hyperalgesia; Male; Mice; Mi | 2012 |
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Diabetes Mellitus, Experimental | 2012 |
Evidence for the participation of peripheral 5-HT₂A, 5-HT₂B, and 5-HT₂C receptors in formalin-induced secondary mechanical allodynia and hyperalgesia.
Topics: Amphetamines; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Fluoxetine; Formaldehyd | 2013 |
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Ac | 2013 |
Involvement of EphB1 receptors signalling in models of inflammatory and neuropathic pain.
Topics: Animals; Carrageenan; Cell Count; Disease Models, Animal; Electrophysiological Phenomena; Female; Fo | 2013 |
Hyperalgesic response in rats fed sucrose from weaning to adulthood: role of VMH.
Topics: Animals; Diet; Eating; Electric Stimulation; Formaldehyde; Hyperalgesia; Male; Pain Measurement; Pai | 2002 |
Effects of intracisternal injection of interleukin-6 on nociceptive jaw opening reflex and orofacial formalin test in freely moving rats.
Topics: Animals; Behavior, Animal; Electromyography; Formaldehyde; Hyperalgesia; Interleukin 1 Receptor Anta | 2003 |
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosid | 2003 |
Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation.
Topics: Animals; Blotting, Western; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relation | 2003 |
Nitroglycerin induces hyperalgesia in rats--a time-course study.
Topics: Animals; Behavior, Animal; Formaldehyde; Hyperalgesia; Male; Nitroglycerin; Pain; Pain Measurement; | 2003 |
Long-term ovariectomy changes formalin-induced licking in female rats: the role of estrogens.
Topics: Animals; Brain; Corticosterone; Estradiol; Estrogens; Female; Formaldehyde; Hindlimb; Hyperalgesia; | 2003 |
Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Dose-Response Relationship, Drug; Formaldehyde; GABA-A R | 2003 |
Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: a comparative study between formalin test and bee venom test in the rat.
Topics: Animals; Bee Venoms; Brain; Formaldehyde; Functional Laterality; Hindlimb; Hyperalgesia; Ibotenic Ac | 2003 |
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain.
Topics: Animals; Binding Sites; Dependovirus; Excitatory Postsynaptic Potentials; Female; Formaldehyde; Gene | 2003 |
Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2003 |
Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain; Carrier Proteins; Dose-Response Relationsh | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyd | 2003 |
Effects of intravenous Injections Paederiae and Stauntonia on spontaneous pain, hyperalgesia and inflammation induced by cutaneous chemical tissue injury in the rat.
Topics: Analgesics; Animals; Bee Venoms; Drugs, Chinese Herbal; Female; Formaldehyde; Hyperalgesia; Inflamma | 2003 |
The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats.
Topics: Analgesics, Opioid; Animals; Arginine; Cyclic GMP; Dinoprostone; Dose-Response Relationship, Drug; F | 2003 |
The effects of exposure to repeated minor pain during the neonatal period on formalin pain behaviour and thermal withdrawal latencies.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Anim | 2003 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot | 2004 |
Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
Topics: Active Transport, Cell Nucleus; Analgesics; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cycl | 2004 |
Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.
Topics: Analgesics, Opioid; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Tolerance; Flavan | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats.
Topics: Animals; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dose-Response Relationship, D | 2004 |
Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Anima | 2004 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Dr | 2005 |
Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, A | 2004 |
Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.
Topics: Acetic Acid; Animals; Carrageenan; Central Nervous System; Constriction, Pathologic; Edema; Formalde | 2004 |
Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats.
Topics: Animals; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphopro | 2005 |
Spinal CK2 regulates nociceptive signaling in models of inflammatory pain.
Topics: Animals; Casein Kinase II; Disease Models, Animal; Formaldehyde; Hyperalgesia; Inflammation; Male; M | 2005 |
Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord.
Topics: Animals; Female; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Knockout; Neurotransmi | 2005 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relations | 2005 |
Intracisternal administration of chemokines facilitated formalin-induced behavioral responses in the orofacial area of freely moving rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chemokine CCL2; Chemokine CCL5; Chemokines; Dose-Re | 2005 |
Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain.
Topics: Acetamides; Animals; Arthritis; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Dru | 2006 |
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.
Topics: Analysis of Variance; Animals; Body Weight; Formaldehyde; Hyperalgesia; In Situ Hybridization; Infla | 2005 |
G-protein activation by neurokinin-1 receptors is dynamically regulated during persistent nociception.
Topics: Animals; Formaldehyde; Freund's Adjuvant; GTP-Binding Proteins; Hyperalgesia; Inflammation; Male; Ra | 2005 |
Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats.
Topics: Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relation | 2005 |
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice.
Topics: Animals; Behavior, Animal; Carrageenan; Cisplatin; Disease Models, Animal; Formaldehyde; Hyperalgesi | 2005 |
GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Formaldehyde; Gangliosides; Hot Tempera | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Animals; Bauhinia; Carrageenan; Constriction, Pathologic | 2005 |
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Topics: Acetates; Acrylamides; Animals; Benzyl Compounds; Dimethyl Sulfoxide; Extracellular Fluid; Formaldeh | 2006 |
Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK).
Topics: Animals; Behavior, Animal; Butadienes; Enzyme Activation; Formaldehyde; Genes, Dominant; Hot Tempera | 2006 |
Peripheral inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity. A spinal microdialysis study in freely moving rats.
Topics: Animals; Cyclooxygenase 2; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activat | 2006 |
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Aci | 2006 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid An | 2006 |
Involvement of cholecystokinin in peripheral nociceptive sensitization during diabetes in rats as revealed by the formalin response.
Topics: Animals; Diabetes Complications; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistanc | 2006 |
CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; DNA Primers; DNA, | 2006 |
Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone.
Topics: Animals; Benzaldehydes; Carrageenan; Edema; Formaldehyde; Hyperalgesia; Male; Mice; Neovascularizati | 2006 |
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Topics: Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spina | 2006 |
Antinociceptive effects of tetrodotoxin (TTX) in rodents.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relation | 2006 |
Interferential therapy produces antinociception during application in various models of inflammatory pain.
Topics: Animals; Carrageenan; Disease Models, Animal; Edema; Fixatives; Formaldehyde; Hyperalgesia; Inflamma | 2006 |
The glutamate transporter GLAST is involved in spinal nociceptive processing.
Topics: Amino Acid Transport System X-AG; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Neurons; | 2006 |
Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection.
Topics: Animals; Formaldehyde; Hyperalgesia; Inflammation; Injections; Mice; Mice, Knockout; Neuralgia; Pain | 2006 |
Pharmacological correlation between the formalin test and the neuropathic pain behavior in different species with chronic constriction injury.
Topics: Animals; Behavior, Animal; Cold Temperature; Dose-Response Relationship, Drug; Formaldehyde; Gerbill | 2006 |
Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists.
Topics: Analgesics; Animals; Apomorphine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 | 2006 |
Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha.
Topics: Analgesics; Animals; DNA, Complementary; Drug Tolerance; Fenofibrate; Formaldehyde; Hyperalgesia; Hy | 2006 |
Expression changes of cation chloride cotransporters in the rat spinal cord following intraplantar formalin.
Topics: Animals; Behavior, Animal; Foot; Formaldehyde; Hyperalgesia; Immunoblotting; Immunohistochemistry; I | 2006 |
Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice.
Topics: Anesthetics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclooxygenase 1; C | 2006 |
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates | 2007 |
Descending serotonergic facilitation of spinal ERK activation and pain behavior.
Topics: Animals; Enzyme Activation; Foot; Formaldehyde; Hyperalgesia; Male; Mitogen-Activated Protein Kinase | 2006 |
Reduced response to the formalin test and lowered spinal NMDA glutamate receptor binding in adenosine A2A receptor knockout mice.
Topics: Animals; Formaldehyde; Hyperalgesia; Male; Mice; Mice, Knockout; Pain Measurement; Pain Threshold; P | 2007 |
Estradiol replacement in ovariectomized rats is antihyperalgesic in the formalin test.
Topics: Animals; Behavior, Animal; Central Nervous System; Corticosterone; Dose-Response Relationship, Drug; | 2007 |
Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: a systematic comparative study in conscious rats.
Topics: Analgesics, Non-Narcotic; Animals; Bee Venoms; Behavior, Animal; Capsaicin; Carrageenan; Edema; Form | 2007 |
Static magnetic field-induced anti-nociceptive effect and the involvement of capsaicin-sensitive sensory nerves in this mechanism.
Topics: Analgesia; Animals; Capsaicin; Carrageenan; Chemoreceptor Cells; Diterpenes; Electromagnetic Fields; | 2007 |
Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents.
Topics: Analysis of Variance; Animals; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; | 2007 |
Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models.
Topics: Animals; Behavior, Animal; CD11b Antigen; Cell Count; Cyclooxygenase 1; Cyclooxygenase 2; Disease Mo | 2007 |
Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mem | 2008 |
15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor.
Topics: Analgesics; Animals; Carrageenan; Cytokines; Formaldehyde; Hyperalgesia; Inflammation; Macrophages; | 2008 |
Role of calcitonin gene-related peptide and substance P in different models of pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Formaldehyde; Hyperalgesia; Immuno | 2008 |
The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity.
Topics: Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2008 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
Long-lasting hyperalgesia and sympathetic dysregulation after formalin injection into the rat hind paw.
Topics: Animals; Autonomic Dysreflexia; Autonomic Nervous System Diseases; Body Temperature; Data Interpreta | 2008 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; F | 1994 |
Antinociceptive activity of filenadol on inflammatory pain.
Topics: Analgesics; Animals; Benzoquinones; Codeine; Formaldehyde; Hyperalgesia; Indomethacin; Inflammation; | 1995 |
Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Formaldehyde; Functional Laterality; | 1995 |
Enhanced nociceptive behaviour following conditioning injection of formalin in the perioral area of the rat.
Topics: Animals; Bupivacaine; Conditioning, Psychological; Formaldehyde; Functional Laterality; Hyperalgesia | 1995 |
Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats.
Topics: Aldehyde Reductase; Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Female; | 1994 |
Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cordotomy; Formaldehyde; Hot Temperature; Hyperalges | 1994 |
Acute and conditioned hyperalgesic responses to illness.
Topics: Animals; Avoidance Learning; Disease; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Intra | 1994 |
Systemic opioids do not suppress spinal sensitization after subcutaneous formalin in rats.
Topics: Alfentanil; Animals; Drug Administration Schedule; Formaldehyde; Hot Temperature; Hyperalgesia; Inje | 1994 |
Central and peripheral actions of the novel kappa-opioid receptor agonist, EMD 60400.
Topics: Analgesics; Animals; Brain; Carrageenan; Dihydroxyphenylalanine; Diuresis; Electric Stimulation; For | 1994 |
Neurocircuitry of illness-induced hyperalgesia.
Topics: Animals; Basal Ganglia; Behavior, Animal; Decerebrate State; Formaldehyde; Ganglia, Sympathetic; Gan | 1994 |
Sustained hyperalgesia can be induced in the rat by a single formalin injection and depends on the initial nociceptive inputs.
Topics: Analysis of Variance; Animals; Bupivacaine; Formaldehyde; Hyperalgesia; Lip; Male; Nociceptors; Rats | 1993 |
Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Gerbillinae; Hype | 1995 |
Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Humans; Hyperalgesia; Injections, Intraperi | 1995 |
Different effects of two aldose reductase inhibitors on nociception and prostaglandin E.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hyperalgesia; In | 1995 |
N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation.
Topics: Amides; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell De | 1996 |
Antinociceptive effects of repeated systemic injections of calcitonin in formalin-induced hyperalgesic rats.
Topics: Analgesics; Animals; Body Weight; Calcitonin; Formaldehyde; Hyperalgesia; Male; Pain Measurement; Ra | 1996 |
A nitric oxide synthesis inhibitor (L-NAME) reduces licking behavior and Fos-labeling in the spinal cord of rats during formalin-induced inflammation.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Immun | 1996 |
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Carrageenan; | 1996 |
Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice.
Topics: Analgesics; Animals; Arginine; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Injections, Intraperit | 1996 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |
Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Excitatory Amino Acid Ant | 1997 |
The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization.
Topics: Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tr | 1997 |
Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias.
Topics: Animals; Formaldehyde; Hyperalgesia; Injections, Intraperitoneal; Injections, Subcutaneous; Lipopoly | 1997 |
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
Topics: Aldehyde Reductase; Anesthetics, Local; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dia | 1996 |
Protein synthesis inhibitor cycloheximide dose-dependently decreases formalin-induced c-Fos protein and behavioral hyperalgesia in rats.
Topics: Animals; Cycloheximide; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Protein | 1997 |
Intrathecally administered c-fos antisense oligodeoxynucleotide decreases formalin-induced nociceptive behavior in adult rats.
Topics: Animals; Behavior, Animal; Formaldehyde; Genes, fos; Hyperalgesia; Injections, Spinal; Male; Neurons | 1997 |
Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
Topics: Animals; Citrates; Formaldehyde; Hydrazones; Hyperalgesia; Injections, Subcutaneous; Interleukin 1 R | 1997 |
Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex.
Topics: Animals; Capsaicin; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Ganglia, Sp | 1997 |
Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats.
Topics: Animals; Drug Tolerance; Formaldehyde; Hindlimb; Hyperalgesia; Male; Morphine; Narcotics; Pain; Plac | 1997 |
Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol.
Topics: 2-Amino-5-phosphonovalerate; Acetaminophen; Analgesics, Non-Narcotic; Animals; Excitatory Amino Acid | 1997 |
Mode of antinociceptive and toxic action of alkaloids of Aconitum spec..
Topics: Aconitine; Analgesics; Animals; Arrhythmias, Cardiac; Batrachotoxins; Calcium; Diterpenes; Drugs, Ch | 1998 |
Autotomy in rats following peripheral nerve transection is attenuated by preceding formalin injections into the same limb.
Topics: Animals; Behavior, Animal; Denervation; Edema; Formaldehyde; Hot Temperature; Hyperalgesia; Male; No | 1998 |
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.
Topics: Aggression; Analgesia; Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Female; | 1998 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Ac | 1998 |
Anti-hyperalgesic effects of tramadol in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Formaldehyde; Hyperalgesia; Male; Nociceptors; Rats; | 1998 |
Spinal serotonergic receptors mediate facilitation of a nociceptive reflex by subcutaneous formalin injection into the hindpaw in rats.
Topics: Animals; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Noci | 1998 |
The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain.
Topics: Amides; Analgesics; Animals; Arachidonic Acids; Cannabinoids; Capillary Permeability; Cystitis; Elec | 1998 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response R | 1998 |
A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Disinfectants; Dose-Response Relationship, D | 1998 |
Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity.
Topics: Acute Disease; Analgesics; Animals; Benzoxazines; Cannabinoids; Disinfectants; Formaldehyde; Hyperal | 1998 |
Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels; Carcinogens; Disinfectants; | 1999 |
Gabapentin prevents hyperalgesia during the formalin test in diabetic rats.
Topics: Acetates; Amines; Analgesics; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diab | 1999 |
[The enhancement of formalin induced agitation behavior by intrathecal administration of prostaglandin E1].
Topics: Alprostadil; Animals; Dose-Response Relationship, Drug; Formaldehyde; Glutamates; Hyperalgesia; Inje | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Anim | 1999 |
Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test.
Topics: Animals; Bee Venoms; Disease Models, Animal; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; | 1999 |
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Rec | 1999 |
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Glutamic Acid; Hyper | 2000 |
Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord.
Topics: Animals; Antibodies; Behavior, Animal; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cycli | 2000 |
Antihyperalgesic effects of intrathecally administered magnesium sulfate in rats.
Topics: Animals; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Spinal; Magnesium Sulfate; Nocicep | 2000 |
Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia.
Topics: Adrenocorticotropic Hormone; Animals; Female; Formaldehyde; Hyperalgesia; Injections, Spinal; Male; | 1999 |
Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat.
Topics: Animals; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Excitatory Amino Aci | 2000 |
A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ca | 2000 |
Effects of persistent nociception on periaqueductal gray glycine release.
Topics: Animals; Formaldehyde; Glutamine; Glycine; Hindlimb; Hyperalgesia; Kinetics; Male; Microdialysis; Pe | 2000 |
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indo | 2000 |
Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat.
Topics: Animals; Camphanes; Cannabinoid Receptor Modulators; Formaldehyde; Hyperalgesia; Male; Piperidines; | 2000 |
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.
Topics: Adenosine Kinase; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, | 2000 |
Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Chronic Disease; Dose-Response Relations | 2000 |
Antihyperalgesic activity of epibatidine in the formalin model of facial pain.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationsh | 2001 |
Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel.
Topics: Acetic Acid; Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Calcium Channel Blockers; Cal | 2001 |
Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice.
Topics: Animals; Arginine; Behavior, Animal; Dinoprostone; Formaldehyde; Gene Deletion; Hyperalgesia; Mice; | 2001 |
Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists.
Topics: Animals; Burns; Calcium; Carrageenan; Excitatory Amino Acid Antagonists; Formaldehyde; Hyperalgesia; | 2001 |
Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model.
Topics: Analgesia; Analgesics; Animals; Formaldehyde; Hyperalgesia; Injections, Intravenous; Injections, Spi | 2001 |
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.
Topics: Alkaloids; Animals; Benzophenanthridines; Bradykinin; Dose-Response Relationship, Drug; Enzyme Inhib | 2002 |
Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail.
Topics: Analgesics, Non-Narcotic; Animals; Formaldehyde; Hindlimb; Hyperalgesia; Inflammation; Male; Meloxic | 2002 |
Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats.
Topics: Animals; Benzhydryl Compounds; Corticosterone; Environmental Pollutants; Estradiol; Estrogens, Non-S | 2002 |
Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw.
Topics: Animals; Behavior, Animal; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; | 2002 |
Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Cyclooxygenase 1; Cycl | 2002 |