| Assay ID | Title | Year | Journal | Article |
|---|
| AID756384 | Apparent permeability from apical to basolateral side in human Caco2 cells at 100 uM after 2 hrs by LC/MS analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID18532 | Rate constant for the compound at a substrate concentration of 262 uM was determined | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K. |
| AID162715 | Amount of proteinase K required to release folin positive amino acids at a substrate concentration of 304 uM | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K. |
| AID1176512 | Intrinsic clearance in human microsomes | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID266247 | Activation of human PEPT1 expressed in MDCK cells relative to Gly-Sar | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. |
| AID18750 | Relativity constant at a substrate concentration of 262 uM | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K. |
| AID1176511 | Intrinsic clearance in rat microsomes | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID756386 | Drug uptake in CHO cells expressing PEPT1 at 100 uM after 15 mins measured per mg of protein by LC/MS analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID756388 | Half life in human liver microsomes at 1 uM by LC/MS analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID1176533 | Inhibition of CYP1A2 (unknown origin) | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID756387 | Drug uptake in CHOK1 cells at 100 uM after 15 mins measured per mg of protein by LC/MS analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID266246 | Activation of human PEPT1 expressed in MDCK cells | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. |
| AID462888 | Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. |
| AID266248 | Ratio of %GSmax to EC50 for human PEPT1 activation | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. |
| AID1176514 | Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID756383 | Apparent permeability from basolateral to apical side in human Caco2 cells at 100 uM after 2 hrs by LC/MS analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID1176503 | Drug recovery in human plasma at 10 uM | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID1176532 | Inhibition of CYP3A4 (unknown origin) | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID756390 | Intrinsic clearance in human liver microsomes at 1 uM by LC/MS analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID266249 | Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. |
| AID462889 | Displacement of [Sar9, Met (O2)11]-SP from human recombinant NK1 receptor at 10 uM | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. |
| AID1176535 | Binding affinity to NK1 receptor (unknown origin) | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID1498740 | Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| An imidazole based H-Phe-Phe-NH |
| AID24002 | Half-life period at a substrate concentration of 262 uM was determined | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K. |
| AID756382 | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in human Caco2 cells | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID462890 | Displacement of [MePhe7]-NKB from human recombinant NK2 receptor at 10 uM | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. |
| AID756385 | Ratio of drug uptake in CHO cells expressing PEPT1 to drug uptake in CHOK1 cells | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID1176505 | Drug recovery in rat plasma at 10 uM | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID756391 | Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. |
| AID1176534 | Inhibition of CYP2C9 (unknown origin) | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID1176531 | Inhibition of CYP2D6 (unknown origin) | 2014 | ACS medicinal chemistry letters, Dec-11, Volume: 5, Issue:12
| Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. |
| AID679004 | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | 1998 | Journal of pharmaceutical sciences, Dec, Volume: 87, Issue:12
| Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |