2-aminoadipic acid has been researched along with Allodynia in 6 studies
2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).
2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " At 4 weeks after tibia fracture and casting in rats, the cast was removed and hind paw allodynia, unweighting, warmth, and edema were measured, then the antinociceptive effects of microglia (minocycline) or astrocyte (L-2-aminoadipic acid (LAA)) inhibitors or an SP receptor antagonist (LY303870) were tested." | 3.81 | Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture. ( Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Sun, Y; Wei, T, 2015) |
| "Intrathecal ketamine (10, 100, 1000 μg/kg) or LAA (10, 50, 100 nmol) alleviated SNL-induced mechanical allodynia in a dose-dependent manner respectively." | 3.76 | Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain. ( Chen, L; Li, YQ; Mei, XP; Wang, W; Wu, SX; Xu, LX; Zhang, T; Zhu, C, 2010) |
| "The mechanical allodynia was dose-dependently attenuated by intrathecal administratration of L-α-aminoadipate (astrocytic specific inhibitor); whereas minocycline (microglial specific inhibitor) had no such effect, indicating that spinal astrocytic activation contributes to allodynia in CNP rat." | 1.39 | Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model. ( Fei, Z; Huang, G; Ji, XT; Jia, D; Li, JM; Li, XK; Niu, L; Qian, NS; Wang, P; Zhang, L; Zhang, T; Zhao, DS, 2013) |
| "In the present study, using a db/db type 2 diabetes mouse model that displayed obvious mechanical allodynia, we found that spinal astrocyte but not microglia was dramatically activated." | 1.37 | Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes. ( Cao, DY; Dou, KF; Gao, CJ; He, F; He, Y; Jia, D; Liao, YH; Qian, NS; Tao, KS; Wang, DS; Wang, P; Yang, YL; Zeng, XT; Zhang, GH; Zhang, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, XT | 1 |
| Qian, NS | 2 |
| Zhang, T | 2 |
| Li, JM | 1 |
| Li, XK | 1 |
| Wang, P | 2 |
| Zhao, DS | 1 |
| Huang, G | 1 |
| Zhang, L | 1 |
| Fei, Z | 1 |
| Jia, D | 2 |
| Niu, L | 1 |
| Ohmichi, M | 1 |
| Ohmichi, Y | 1 |
| Ohishi, H | 1 |
| Yoshimoto, T | 1 |
| Morimoto, A | 1 |
| Li, Y | 1 |
| Sakurai, H | 1 |
| Nakano, T | 1 |
| Sato, J | 1 |
| Li, WW | 1 |
| Guo, TZ | 1 |
| Shi, X | 1 |
| Sun, Y | 1 |
| Wei, T | 1 |
| Clark, DJ | 1 |
| Kingery, WS | 1 |
| Gao, YJ | 1 |
| Ji, RR | 1 |
| Mei, XP | 1 |
| Wang, W | 2 |
| Zhu, C | 1 |
| Chen, L | 1 |
| Xu, LX | 1 |
| Wu, SX | 1 |
| Li, YQ | 1 |
| Liao, YH | 1 |
| Zhang, GH | 1 |
| He, F | 1 |
| Zeng, XT | 1 |
| He, Y | 1 |
| Yang, YL | 1 |
| Cao, DY | 1 |
| Zhang, Y | 1 |
| Wang, DS | 1 |
| Tao, KS | 1 |
| Gao, CJ | 1 |
| Dou, KF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy[NCT04920097] | 240 participants (Anticipated) | Interventional | 2021-07-08 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for 2-aminoadipic acid and Allodynia
| Article | Year |
|---|---|
Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Gene Expression; Hyperalgesia; Injections, Spinal; Interleu | 2013 |
Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization.
Topics: 2-Aminoadipic Acid; Activating Transcription Factor 3; Animals; Astrocytes; Casts, Surgical; CD11b A | 2014 |
Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture.
Topics: 2-Aminoadipic Acid; Animals; Anti-Inflammatory Agents; Complex Regional Pain Syndromes; Disease Mode | 2015 |
Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia.
Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Astrocytes; Citrates; Disease Models, Animal; Ede | 2010 |
Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain.
Topics: 2-Aminoadipic Acid; Analgesics; Animals; Astrocytes; Dose-Response Relationship, Drug; Drug Therapy, | 2010 |
Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease M | 2011 |