Compounds > jnj 10191584
Page last updated: 2024-11-12

jnj 10191584

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

JNJ 10191584: histamine H4 receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10446295
CHEMBL ID185951
CHEBI ID92272
SCHEMBL ID602043
SCHEMBL ID16939347
MeSH IDM0493745

Synonyms (32)

Synonym
BRD-K15086322-103-01-0
vuf 6002
gtpl1277
(6-chloro-1h-benzimidazol-2-yl)-(4-methylpiperazin-1-yl)methanone
jnj 10191584
CHEMBL185951 ,
jnj-10191584
(5-chloro-1h-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
(5-chloro-1h-benzoimidazol-2-yl)(4-methylpiperazin-1-yl)methanone
bdbm50179335
AKOS015994569
(6-chloro-1h-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
piperazine, 1-[(5-chloro-1h-benzimidazol-2-yl)carbonyl]-4-methyl-
73903-17-0
SCHEMBL602043
7ee5t3wl8p ,
piperazine, 1-((5-chloro-1h-benzimidazol-2-yl)carbonyl)-4-methyl-
unii-7ee5t3wl8p
(5-chloro-1h-benzimidazol-2-yl)(4-methylpiperazin-1-yl)methanone
vuf-6002
methanone, (6-chloro-1h-benzimidazol-2-yl)(4-methyl-1-piperazinyl)-
ES-0014
SCHEMBL16939347
CHEBI:92272
jnj10191584
Q7907646
jnj 10191584 (maleate)
6-chloro-2-(4-methylpiperazine-1-carbonyl)-1h-1,3-benzodiazole
CS-0082926
HY-123532
DTXSID801170826
E98838

Research Excerpts

Treatment

ExcerptReferenceRelevance
"Treatment with JNJ 10191584 (10-100 mg/kg p.o., b.i.d.) caused a dose-dependent reduction in macroscopic damage, inhibition of the TNBS-provoked elevation of both colonic myeloperoxidase and tumour necrosis factor-alpha (TNF-alpha), and a reduction in the histologically assessed increase in mucosal and submucosal thickness and neutrophil infiltration."( Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.
Berko, A; Dunford, PJ; Horvath, K; Thurmond, RL; Varga, C; Whittle, BJ, 2005)		0.67
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzimidazolesAn organic heterocyclic compound containing a benzene ring fused to an imidazole ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Histamine H4 receptorHomo sapiens (human)IC50 (µMol)0.33400.00070.630510.0000AID256876; AID256877
Histamine H4 receptorHomo sapiens (human)Ki0.03910.00060.478710.0000AID1127886; AID239984; AID256865; AID594143; AID630911; AID630917; AID638337; AID640808; AID640809
Histamine H3 receptorHomo sapiens (human)Ki12.67800.00010.33998.5110AID239983; AID256878; AID640810
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Histamine H4 receptorHomo sapiens (human)Kd0.02000.00400.01940.0702AID256866
Histamine H3 receptorHomo sapiens (human)EC50 (µMol)3.16230.00000.09473.1623AID243150
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Processvia Protein(s)Taxonomy
inflammatory responseHistamine H4 receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationHistamine H4 receptorHomo sapiens (human)
biological_processHistamine H4 receptorHomo sapiens (human)
regulation of MAPK cascadeHistamine H4 receptorHomo sapiens (human)
G protein-coupled serotonin receptor signaling pathwayHistamine H4 receptorHomo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayHistamine H4 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerHistamine H4 receptorHomo sapiens (human)
chemical synaptic transmissionHistamine H4 receptorHomo sapiens (human)
neurotransmitter secretionHistamine H3 receptorHomo sapiens (human)
G protein-coupled serotonin receptor signaling pathwayHistamine H3 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerHistamine H3 receptorHomo sapiens (human)
chemical synaptic transmissionHistamine H3 receptorHomo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayHistamine H3 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
histamine receptor activityHistamine H4 receptorHomo sapiens (human)
G protein-coupled serotonin receptor activityHistamine H4 receptorHomo sapiens (human)
G protein-coupled acetylcholine receptor activityHistamine H4 receptorHomo sapiens (human)
histamine receptor activityHistamine H3 receptorHomo sapiens (human)
G protein-coupled acetylcholine receptor activityHistamine H3 receptorHomo sapiens (human)
G protein-coupled serotonin receptor activityHistamine H3 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
plasma membraneHistamine H4 receptorHomo sapiens (human)
plasma membraneHistamine H4 receptorHomo sapiens (human)
dendriteHistamine H4 receptorHomo sapiens (human)
synapseHistamine H4 receptorHomo sapiens (human)
plasma membraneHistamine H3 receptorHomo sapiens (human)
presynapseHistamine H3 receptorHomo sapiens (human)
plasma membraneHistamine H3 receptorHomo sapiens (human)
synapseHistamine H3 receptorHomo sapiens (human)
dendriteHistamine H3 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID244406Intrinsic activity against human histamine H3 receptor2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
AID640808Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID630911Antagonist activity at human histamine H4 receptor by functional assay2011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
AID256874Oral bioavailability in rat administered with 10 mg/kg, po2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID256877Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptor2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID256871Maximum concentration in rat administered with 10 mg/kg, po2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID1127886Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis2014Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6
Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
AID640814Clearance in rat at 10 mg/kg, sc2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID256878Binding affinity to histamine H3 receptor2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID640817Half life in rat at 10 mg/kg, sc2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID256869In vitro half life in rat liver microsomes2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID256868In vitro half life in human S9 fraction2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID256876Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID640811Metabolic stability in human liver microsomes2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID243150Effective concentration required against human histamine H3 receptor was determined by the inhibition of the cAMP stimulated beta-galactosidase transcription in SK-N-MC cells2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
AID256873Area under curve in rat administered with 10 mg/kg, po2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID256870In vitro half life in rat S9 fraction2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID256866Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID256867In vitro half life in human liver microsomes2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID594143Displacement of [3H]histamine from human histamine H4 receptor2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.
AID256865Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID640820Volume of distribution in rat at 10 mg/kg, sc2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID239984Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
AID1693533Antagonist activity at human histamine 4 receptor transfected in human HEK293T cells assessed as reduction in histamine-induced activity at 10 uM incubated for 30 mins followed by histamine stimulation and measured immediately by BRET assay
AID630917Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique2011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
AID239983Binding affinity towards human histamine H3 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
AID638590Displacement of [3H]histamine from human H4R assessed as binding half life2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
AID638337Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
AID256872Half life in rat administered with 10 mg/kg, po2005Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
AID640812Metabolic stability in rat liver microsomes2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID640810Binding affinity to human histamine H3 receptor2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID640809Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay2012Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
Synthesis of novel histamine H4 receptor antagonists.
AID1346055Human H4 receptor (Histamine receptors)2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (33.33)29.6817
2010's12 (57.14)24.3611
2020's2 (9.52)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.61 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		3.1850aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
betahistine
Betahistine: A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.. betahistine : An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.		2.0710aminoalkylpyridine;
secondary amino compound		H1-receptor agonist;
vasodilator agent
chlorpheniramine
Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.. chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.		2.1310monochlorobenzenes;
pyridines;
tertiary amino compound		anti-allergic agent;
antidepressant;
antipruritic drug;
H1-receptor antagonist;
histamine antagonist;
serotonin uptake inhibitor
clonidine
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.		2.2510clonidine;
imidazoline
dimaprit
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.		2.110imidothiocarbamic ester
trinitrobenzenesulfonic acid
Trinitrobenzenesulfonic Acid: A reagent that is used to neutralize peptide terminal amino groups.. 2,4,6-trinitrobenzenesulfonic acid : The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.		2.0210arenesulfonic acid;
C-nitro compound		epitope;
explosive;
reagent
4-methylhistamine
4-methylhistamine: RN given refers to parent cpd. 4-methylhistamine : An aralkylamino compound that is histamine bearing a methyl substituent at the 5 position on the ring.		2.110aralkylamino compound;
imidazoles		histamine agonist;
metabolite
thiourea
Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.		2.8130one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
ranitidine
Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.. ranitidine : A member of the class of furans used to treat peptic ulcer disease (PUD) and gastroesophageal reflux disease.		2.1310C-nitro compound;
furans;
organic sulfide;
tertiary amino compound		anti-ulcer drug;
drug allergen;
environmental contaminant;
H2-receptor antagonist;
xenobiotic
thioperamide
thioperamide: structure given in first source; histamine H3 receptor antagonist		2.7730primary aliphatic amine
vuf 8430
S-(2-guanidylethyl)isothiourea: a histamine H4 receptor agonist; structure in first source		2.8130
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		2.0310
jnj 7777120
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine: an H4 receptor antagonist; structure in first source		5.23150
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		2.0210aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
6,7-dichloro 3-(4-methylpiperazin-1-yl)quinoxalin-2(1h)-one
6,7-dichloro 3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one: an NSAID; structure in first source		2.0710
piperidines
Piperidines: A family of hexahydropyridines.		2.4820
leptin
Leptin: A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Allergic Reaction
[description not available]		02.0710
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.		02.0710
Polyarthritis
[description not available]		02.110
Itching
[description not available]		02.110
Arthritis
Acute or chronic inflammation of JOINTS.		02.110
Pruritus
An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.		02.110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.7630
Anasarca
[description not available]		02.0310
Allodynia
[description not available]		02.4720
Innate Inflammatory Response
[description not available]		03.6430
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0310
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		03.6430
Nerve Pain
[description not available]		02.5720
Neuralgia
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.		02.5720
Choroid Neovascularization
[description not available]		02.110
Age-Related Macular Degeneration
[description not available]		02.110
Macular Degeneration
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.		02.110
Hemorrhagic Shock
[description not available]		02.1310
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0210
Acute Disease
Disease having a short and relatively severe course.		02.0210
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		02.0210
Airway Hyper-Responsiveness
[description not available]		02.0310
Diseases of Immune System
[description not available]		02.9510
Immune System Diseases
Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.		02.9510