bupivacaine has been researched along with Allodynia in 50 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats." | 7.76 | Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010) |
| " Preincisional subcutaneous bupivacaine selectively suppresses and shortens allodynia for times far outlasting its local anesthesia, an effect largely from systemic actions." | 7.73 | Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. ( Duarte, AM; Hamaya, Y; Mujenda, F; Pospisilova, E; Reilly, E; Strichartz, GR, 2005) |
| "Rats exhibited both mechanical and cold allodynia, but not thermal hyperalgesia, within 3 days and up to 21 days post-SNL." | 5.42 | Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model. ( Averitt, DL; Clifford, JL; Hansen, J; Mares, A, 2015) |
| "Acute postoperative pain causes physiological deficits and slows recovery." | 5.39 | Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. ( Blaskovich, PD; Costa, DS; Herman, CJ; Hildebrand, WP; Nichols, GA; Ohri, R; Pham, LN; Scarborough, NL; Strichartz, GR; Wang, JC, 2013) |
| "We report the case of a 60 year old patient on chronic Intrathecal combined fentanyl and Bupivacaine who had worsening pain with increasing doses and improved after weaning off intrathecal opioids." | 3.91 | Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl. ( Acquadro, MA; Cheng, Y; Farah, F; Gerges, FJ; Kalaydjian, A, 2019) |
| "Microsphere bupivacaine released near the incision reduced the chronic tactile allodynia after thoracotomy." | 3.81 | Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres. ( Blaskovich, P; Ohri, R; Strichartz, GR; Wang, JC, 2015) |
| "Our studies showed that subcutaneous duloxetine (2 mg) reduced hyperalgesia and allodynia for several days after skin incision, whereas subcutaneous bupivacaine (2 mg) did not." | 3.81 | The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model. ( Russell, G; Strichartz, GR; Wang, CF; Wang, GK, 2015) |
| " The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats." | 3.76 | Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010) |
| " In this study, we evaluated the effect of bupivacaine administered via a nerve block or via a systemic route on the spinal expression of PGE2 and COX in a model of peripheral inflammation in rats." | 3.75 | The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. ( Beloeil, H; Benhamou, D; Gentili, M; Mazoit, JX, 2009) |
| " Following the unilateral intraplantar injection of BmK venom into rat hind paw, it was found: 1) BmK venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von Frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress BmK venom-induced pain responses with different intensity and time courses." | 3.73 | Rat pain-related responses induced by experimental scorpion BmK sting. ( Bai, ZT; Chai, ZF; Ji, YH; Liu, T; Pang, XY, 2006) |
| " Preincisional subcutaneous bupivacaine selectively suppresses and shortens allodynia for times far outlasting its local anesthesia, an effect largely from systemic actions." | 3.73 | Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. ( Duarte, AM; Hamaya, Y; Mujenda, F; Pospisilova, E; Reilly, E; Strichartz, GR, 2005) |
| "Different mechanisms underlie hyperalgesia localized at areas surrounding the site of pain and hyperalgesia generalized to distant body areas." | 2.71 | Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. ( Arendt-Nielsen, L; Curatolo, M; Di Stefano, G; Herren-Gerber, R; Petersen-Felix, S; Radanov, BP; Weiss, S, 2004) |
| "Mechanical hyperalgesia was measured by von Frey filaments." | 2.71 | The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. ( De Kock, M; Lavand'homme, P; Waterloos, H, 2005) |
| "Mechanical allodynia was assessed by withdrawal from application of von Frey filaments, and local tolerance was evaluated by histology." | 1.91 | Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain. ( Glass, CM; Heffernan, JM; McLaren, AC; Overstreet, DJ, 2023) |
| "At Day 1, partial reversal of mechanical allodynia in aboBoNT-A groups was followed by a full reversal from Day 3." | 1.72 | Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model. ( Carré, D; Castel, D; Cornet, S; Evans, S; Horne, R; Kalinichev, M; Lezmi, S; Limana, L; Meilin, S; Pons, L, 2022) |
| "The mechanical allodynia, thermal hyperalgesia and thermal allodynia was assessed by pain behavioral tests." | 1.62 | Low concentration of Bupivacaine ameliorates painful diabetic neuropathy by mediating miR-23a/PDE4B axis in microglia. ( Ju, F; Liao, O; Xia, L; Xie, A; Zhang, X; Zhou, Y, 2021) |
| "Chronic neuropathic pain following traumatic brachial plexus injury could be successfully managed by chemical neurolysis and oral gabapentin." | 1.51 | Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report. ( Aaron, OI; Adetoye, AO; Orimolade, EA; P Adetifa, KA, 2019) |
| "Bupivacaine was steadily released as measured in vitro over 35 days." | 1.48 | Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. ( Dai, F; Hurwitz, O; LaMotte, RH; Ma, C; Shimada, SG; Tian, D; Wang, T; Zhou, J, 2018) |
| " Formulations of Gelfoam® and BP-PLGA microparticles (GelBP), with three targeted dosing profiles (0." | 1.48 | A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. ( Haines, LG; Harrington, JM; Johnson, LM; Nackley, AG; O'Buckley, SC; Rothrock, GD; Shepherd, SD, 2018) |
| "The opioid-induced hyperalgesia may occur in early postoperative period." | 1.43 | [THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD]. ( Dmytriyev, DV, 2016) |
| "Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia." | 1.42 | Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats. ( Brennan, TJ; Dalm, BD; Howard, MA; Kang, S; Reddy, CG, 2015) |
| "Subsequently, sufentanil induced hyperalgesia in diabetic and non-diabetic mice." | 1.42 | Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice. ( Blaes, N; Fourcade, O; Francès, B; Girolami, JP; Gomez-Brouchet, A; Minville, V; Mouledous, L; Tack, I, 2015) |
| "There was "rebound hyperalgesia" to thermal stimulus after the resolution of plain bupivacaine sciatic nerve block." | 1.42 | Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. ( An, K; Elkassabany, NM; Liu, J, 2015) |
| "Levobupivacaine was more potent than lidocaine in all tests employed on diabetic rats." | 1.39 | Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. ( Gunay, I; Gunes, Y; Mert, T, 2013) |
| "Acute postoperative pain causes physiological deficits and slows recovery." | 1.39 | Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. ( Blaskovich, PD; Costa, DS; Herman, CJ; Hildebrand, WP; Nichols, GA; Ohri, R; Pham, LN; Scarborough, NL; Strichartz, GR; Wang, JC, 2013) |
| "Tricyclic antidepressants (TCA) have potent local anesthetic properties and may produce a long-lasting pain blockade that could be of interest in relieving chronic pain states such as neuropathic pain, but there are only few data comparing their dose-response curves of analgesic activity under the same experimental conditions." | 1.36 | Analgesic and antiallodynic effects of antidepressants after infiltration into the rat. ( del Valle, J; Domenech, J; Escribano, E; Garcia, X; Queralt, J, 2010) |
| "Thermal hyperalgesia was assessed daily from day 1 to day 10 after UVA-light exposure by measuring response latency to noxious heat (tail immersion in 49 degrees C water)." | 1.34 | Pre-emptive ring-block with bupivacaine prevents the development of thermal hyperalgesia, but not sustained mechanical hyperalgesia, in rat tails exposed to ultraviolet A light. ( Kamerman, P; Mitchell, D; Themistocleous, A, 2007) |
| "The incisional allodynia and the carrageenan-induced hyperalgesia were intensified by the microinjection of 2% lidocaine into the contralateral, but not ipsilateral APtN, the effect being significantly stronger when a large incision or a higher carrageenan concentration was utilized." | 1.32 | Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat. ( Del Bel, EA; Prado, WA; Villarreal, CF, 2003) |
| "Bupivacaine microspheres treatment produced conduction blockade with a complete lack of sensory responsiveness in the sural territory for 6 to 10 days." | 1.32 | Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. ( Berde, CB; Decosterd, I; Gilliard, N; Papaloïzos, M; Spahn, DR; Suter, MR; Woolf, CJ, 2003) |
| "Bupivacaine (1." | 1.32 | Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation. ( Ecoffey, C; Estebe, JP; Gentili, ME; Le Corre, P; Leduc, C; Moulinoux, JP, 2004) |
| "Secondary hyperalgesia, an exaggerated response to stimuli applied to undamaged tissue surrounding an injury, is a common consequence of tissue injury and inflammation." | 1.31 | Persistent secondary hyperalgesia after gastrocnemius incision in the rat. ( Brennan, TJ; Niemeier, JS; Pogatzki, EM, 2002) |
| "Inflammatory hyperalgesia was completely prevented by the precarrageenan injection of RTX." | 1.31 | Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity. ( Bradley, EL; Bright, CA; Kissin, I, 2002) |
| "Hyperalgesia was persistent through 2 days after surgery and then gradually returned toward preincision values over the next 4 days." | 1.30 | Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain. ( Brennan, TJ; Umali, EF; Zahn, PK, 1997) |
| "The resulting hyperalgesia to radiant heat and spontaneous nociceptive behaviors was assessed by using a foot-withdrawal test and a spontaneous pain behavior rating method, respectively." | 1.28 | Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (16.00) | 18.2507 |
| 2000's | 21 (42.00) | 29.6817 |
| 2010's | 17 (34.00) | 24.3611 |
| 2020's | 4 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, CC | 1 |
| Chang, CY | 1 |
| Tzeng, CY | 1 |
| Huang, JH | 1 |
| Hung, CJ | 1 |
| Chen, WY | 1 |
| Liao, SL | 1 |
| Kuan, YH | 1 |
| Chen, CJ | 1 |
| Heffernan, JM | 1 |
| McLaren, AC | 1 |
| Glass, CM | 1 |
| Overstreet, DJ | 1 |
| Cornet, S | 2 |
| Carré, D | 2 |
| Limana, L | 2 |
| Castel, D | 2 |
| Meilin, S | 2 |
| Horne, R | 2 |
| Pons, L | 2 |
| Evans, S | 2 |
| Lezmi, S | 2 |
| Kalinichev, M | 2 |
| Adetoye, AO | 1 |
| Aaron, OI | 1 |
| Orimolade, EA | 1 |
| P Adetifa, KA | 1 |
| Zhang, X | 1 |
| Xia, L | 1 |
| Xie, A | 1 |
| Liao, O | 1 |
| Ju, F | 1 |
| Zhou, Y | 1 |
| Ji, ZH | 1 |
| Liu, ZJ | 1 |
| Liu, ZT | 1 |
| Zhao, W | 1 |
| Williams, BA | 1 |
| Zhang, HF | 1 |
| Li, L | 1 |
| Xu, SY | 1 |
| Wang, T | 1 |
| Hurwitz, O | 1 |
| Shimada, SG | 1 |
| Tian, D | 1 |
| Dai, F | 1 |
| Zhou, J | 1 |
| Ma, C | 1 |
| LaMotte, RH | 1 |
| Shepherd, SD | 1 |
| O'Buckley, SC | 1 |
| Harrington, JM | 1 |
| Haines, LG | 1 |
| Rothrock, GD | 1 |
| Johnson, LM | 1 |
| Nackley, AG | 1 |
| Kalaydjian, A | 1 |
| Farah, F | 1 |
| Cheng, Y | 1 |
| Acquadro, MA | 1 |
| Gerges, FJ | 1 |
| Ohri, R | 2 |
| Wang, JC | 2 |
| Blaskovich, PD | 1 |
| Pham, LN | 1 |
| Costa, DS | 1 |
| Nichols, GA | 1 |
| Hildebrand, WP | 1 |
| Scarborough, NL | 1 |
| Herman, CJ | 1 |
| Strichartz, GR | 4 |
| An, K | 1 |
| Elkassabany, NM | 1 |
| Liu, J | 1 |
| Blaskovich, P | 1 |
| Wang, CF | 1 |
| Russell, G | 1 |
| Wang, GK | 1 |
| Gomez-Brouchet, A | 1 |
| Blaes, N | 1 |
| Mouledous, L | 1 |
| Fourcade, O | 1 |
| Tack, I | 1 |
| Francès, B | 1 |
| Girolami, JP | 1 |
| Minville, V | 1 |
| Clifford, JL | 1 |
| Mares, A | 1 |
| Hansen, J | 1 |
| Averitt, DL | 1 |
| Dalm, BD | 1 |
| Reddy, CG | 1 |
| Howard, MA | 1 |
| Kang, S | 1 |
| Brennan, TJ | 5 |
| Dmytriyev, DV | 1 |
| Campos, CR | 1 |
| Ocheltree, SM | 1 |
| Hom, S | 1 |
| Egleton, RD | 1 |
| Davis, TP | 1 |
| Xu, J | 1 |
| Rodriguez-Navarro, AJ | 1 |
| Lagos, M | 1 |
| Figueroa, C | 1 |
| Garcia, C | 1 |
| Recabal, P | 1 |
| Silva, P | 1 |
| Iglesias, V | 1 |
| Lagos, N | 1 |
| Beloeil, H | 2 |
| Gentili, M | 1 |
| Benhamou, D | 2 |
| Mazoit, JX | 2 |
| Combettes, E | 1 |
| Garcia, X | 1 |
| del Valle, J | 1 |
| Escribano, E | 1 |
| Domenech, J | 1 |
| Queralt, J | 1 |
| Mert, T | 1 |
| Gunes, Y | 1 |
| Gunay, I | 1 |
| Birkelund, T | 1 |
| Revenfeld, TS | 1 |
| Møller, JF | 1 |
| Pogatzki, EM | 2 |
| Niemeier, JS | 1 |
| Villarreal, CF | 1 |
| Del Bel, EA | 1 |
| Prado, WA | 1 |
| Jasmin, L | 1 |
| Rabkin, SD | 1 |
| Granato, A | 1 |
| Boudah, A | 1 |
| Ohara, PT | 1 |
| Hasirci, V | 1 |
| Bonney, I | 1 |
| Goudas, LC | 1 |
| Shuster, L | 1 |
| Carr, DB | 1 |
| Wise, DL | 1 |
| Suter, MR | 1 |
| Papaloïzos, M | 1 |
| Berde, CB | 1 |
| Woolf, CJ | 1 |
| Gilliard, N | 1 |
| Spahn, DR | 1 |
| Decosterd, I | 1 |
| Estebe, JP | 1 |
| Gentili, ME | 1 |
| Le Corre, P | 1 |
| Leduc, C | 1 |
| Moulinoux, JP | 1 |
| Ecoffey, C | 1 |
| Herren-Gerber, R | 1 |
| Weiss, S | 1 |
| Arendt-Nielsen, L | 1 |
| Petersen-Felix, S | 1 |
| Di Stefano, G | 1 |
| Radanov, BP | 1 |
| Curatolo, M | 1 |
| Xie, W | 1 |
| Strong, JA | 1 |
| Meij, JTA | 1 |
| Zhang, JM | 2 |
| Yu, L | 1 |
| Duarte, AM | 1 |
| Pospisilova, E | 1 |
| Reilly, E | 1 |
| Mujenda, F | 1 |
| Hamaya, Y | 1 |
| De Kock, M | 1 |
| Lavand'homme, P | 1 |
| Waterloos, H | 1 |
| Bai, ZT | 1 |
| Liu, T | 1 |
| Chai, ZF | 1 |
| Pang, XY | 1 |
| Ji, YH | 1 |
| Themistocleous, A | 1 |
| Kamerman, P | 1 |
| Mitchell, D | 1 |
| Ayesh, EE | 1 |
| Ernberg, M | 1 |
| Svensson, P | 1 |
| Cadet, R | 2 |
| Aigouy, L | 2 |
| Woda, A | 2 |
| Christie, JM | 1 |
| Chen, GW | 1 |
| Brennum, J | 1 |
| Umali, EF | 1 |
| Zahn, PK | 1 |
| De Lima, J | 1 |
| Alvares, D | 1 |
| Hatch, DJ | 1 |
| Fitzgerald, M | 1 |
| Fu, KY | 1 |
| Light, AR | 1 |
| Maixner, W | 1 |
| Homma, Y | 1 |
| Ackerman, WE | 1 |
| Brull, SJ | 1 |
| Kissin, I | 1 |
| Bright, CA | 1 |
| Bradley, EL | 1 |
| Vandermeulen, EP | 1 |
| Mao, J | 1 |
| Price, DD | 1 |
| Mayer, DJ | 1 |
| Lu, J | 1 |
| Hayes, RL | 1 |
| Raja, SN | 1 |
| Treede, RD | 1 |
| Davis, KD | 1 |
| Campbell, JN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Study Between Dexamethasone, and Dexmedetomidine as Additives to Bupivacaine in Ultrasound Guided Adductor Canal Block in Knee Arthroscopy[NCT04631822] | 42 participants (Anticipated) | Interventional | 2021-01-01 | Not yet recruiting | |||
| Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty: A Double Blind Randomized Study[NCT03025594] | Phase 3 | 64 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| The Evaluation Of The Efficacy Of Auriculotemporal Nerve Block In Temporomandibular Disorders[NCT04827784] | 22 participants (Actual) | Interventional | 2020-01-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for bupivacaine and Allodynia
| Article | Year |
|---|---|
Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: development of a long-acting pain blocker.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug | 2009 |
Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury.
Topics: Adult; Bupivacaine; Chronic Disease; Female; Humans; Hyperalgesia; Male; Middle Aged; Neck Muscles; | 2004 |
The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery.
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Anest | 2005 |
Effects of local anesthetics on somatosensory function in the temporomandibular joint area.
Topics: Adult; Anesthetics, Local; Arthralgia; Bupivacaine; Double-Blind Method; Female; Humans; Hyperalgesi | 2007 |
Secondary hyperalgesia is not affected by wound infiltration with bupivacaine.
Topics: Adult; Analgesia, Obstetrical; Bupivacaine; Cesarean Section; Double-Blind Method; Female; Humans; H | 1993 |
Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain.
Topics: Adult; Bupivacaine; Chronic Disease; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Hemodyn | 1991 |
44 other studies available for bupivacaine and Allodynia
| Article | Year |
|---|---|
Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury.
Topics: Animals; Bupivacaine; Constriction; Crush Injuries; Cytokines; HMGB1 Protein; Hyperalgesia; Injectio | 2022 |
Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain.
Topics: Acrylamides; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Hydrogels; Hyperalgesia; Meloxicam | 2023 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report.
Topics: Adult; Aged; Analgesics; Brachial Plexus; Brachial Plexus Neuropathies; Bupivacaine; Gabapentin; Hum | 2019 |
Low concentration of Bupivacaine ameliorates painful diabetic neuropathy by mediating miR-23a/PDE4B axis in microglia.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Blood Glucose; Bupivacaine; Cerebral Cortex; Cyclic N | 2021 |
Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress.
Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetic Neuropathies; Electrophysiology; Enzyme Inhibitor | 2017 |
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Lac | 2018 |
A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain.
Topics: Analgesics; Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Drug Compounding; | 2018 |
Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl.
Topics: Analgesics, Opioid; Bupivacaine; Female; Fentanyl; Humans; Hyperalgesia; Infusion Pumps, Implantable | 2019 |
Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Data Interpretation, | 2013 |
Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model.
Topics: Anesthetics, Local; Animals; Axons; Bupivacaine; Chemotherapy, Adjuvant; Dexamethasone; Disease Mode | 2015 |
Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres.
Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Drug Administration Schedule; | 2015 |
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Cells, Cultured; De | 2015 |
Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Animals; Bupivacaine; Diabetes Mellitus, Experimental; H | 2015 |
Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cold Temperature; Hyperalgesia; Ligation; Male; Rats; Rats | 2015 |
Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Conditioning, Psychological; Disease Mod | 2015 |
[THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD].
Topics: Abdominal Neoplasms; Adolescent; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Spinal; Anest | 2016 |
Nociceptive inhibition prevents inflammatory pain induced changes in the blood-brain barrier.
Topics: Anesthetics, Local; Animals; Blood-Brain Barrier; Brain Edema; Bupivacaine; Carrageenan; Claudin-5; | 2008 |
Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Dermatologic Surgical | 2009 |
The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats.
Topics: Animals; Bupivacaine; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Edema; Gene Expression Regul | 2009 |
Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Dinoprostone; Dis | 2010 |
Analgesic and antiallodynic effects of antidepressants after infiltration into the rat.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Anesthetics, Local; Animals; Antidepressive Agents, Tricyc | 2010 |
Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy.
Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Disease Models, Animal; F | 2013 |
[Transient segmental hyperalgesia following epidural analgesia].
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Di | 2012 |
Persistent secondary hyperalgesia after gastrocnemius incision in the rat.
Topics: Anesthetics, Local; Animals; Bupivacaine; Hindlimb; Hot Temperature; Hyperalgesia; Lidocaine; Male; | 2002 |
Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat.
Topics: Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Dose-Response Relatio | 2003 |
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge | 2003 |
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block.
Topics: Animals; Bupivacaine; Hyperalgesia; Male; Nerve Block; Pain Management; Peripheral Nerve Injuries; R | 2003 |
Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.
Topics: Amitriptyline; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Hypera | 2004 |
Neuropathic pain: early spontaneous afferent activity is the trigger.
Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Axotomy; Behavior, Animal; Bup | 2005 |
Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat.
Topics: Animals; Bupivacaine; Hair Follicle; Hyperalgesia; Injections, Subcutaneous; Male; Pain Measurement; | 2005 |
Rat pain-related responses induced by experimental scorpion BmK sting.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain | 2006 |
Pre-emptive ring-block with bupivacaine prevents the development of thermal hyperalgesia, but not sustained mechanical hyperalgesia, in rat tails exposed to ultraviolet A light.
Topics: Analysis of Variance; Animals; Bupivacaine; Hyperalgesia; Male; Nerve Block; Nerve Fibers, Unmyelina | 2007 |
Enhanced nociceptive behaviour following conditioning injection of formalin in the perioral area of the rat.
Topics: Animals; Bupivacaine; Conditioning, Psychological; Formaldehyde; Functional Laterality; Hyperalgesia | 1995 |
Sustained hyperalgesia can be induced in the rat by a single formalin injection and depends on the initial nociceptive inputs.
Topics: Analysis of Variance; Animals; Bupivacaine; Formaldehyde; Hyperalgesia; Lip; Male; Nociceptors; Rats | 1993 |
Quantitative sensory examination of epidural anaesthesia and analgesia in man.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Evok | 1996 |
Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Bupivacaine; Hyperalgesia; Injections, Spinal; Male | 1997 |
Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Bupivacaine; Hyperalgesia; Nerve Block; Rats; Rats, S | 1999 |
Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Chronic Disease; Dose-Response Relations | 2000 |
Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat.
Topics: Administration, Topical; Animals; Bupivacaine; Ganglia, Spinal; Hydrogen-Ion Concentration; Hyperalg | 2001 |
Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity.
Topics: Animals; Bupivacaine; Capsaicin; Carrageenan; Diterpenes; Hyperalgesia; Male; Nerve Block; Periphera | 2002 |
Effect of plantar local anesthetic injection on dorsal horn neuron activity and pain behaviors caused by incision.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Electrophysiology; Hindlimb; Hyperalgesi | 2002 |
Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.
Topics: Anesthesia, Local; Animals; Bupivacaine; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism | 1992 |