Page last updated: 2024-10-24

bupivacaine and Allodynia

bupivacaine has been researched along with Allodynia in 50 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

ExcerptRelevanceReference
" The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats."7.76Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010)
" Preincisional subcutaneous bupivacaine selectively suppresses and shortens allodynia for times far outlasting its local anesthesia, an effect largely from systemic actions."7.73Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. ( Duarte, AM; Hamaya, Y; Mujenda, F; Pospisilova, E; Reilly, E; Strichartz, GR, 2005)
"Rats exhibited both mechanical and cold allodynia, but not thermal hyperalgesia, within 3 days and up to 21 days post-SNL."5.42Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model. ( Averitt, DL; Clifford, JL; Hansen, J; Mares, A, 2015)
"Acute postoperative pain causes physiological deficits and slows recovery."5.39Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. ( Blaskovich, PD; Costa, DS; Herman, CJ; Hildebrand, WP; Nichols, GA; Ohri, R; Pham, LN; Scarborough, NL; Strichartz, GR; Wang, JC, 2013)
"We report the case of a 60 year old patient on chronic Intrathecal combined fentanyl and Bupivacaine who had worsening pain with increasing doses and improved after weaning off intrathecal opioids."3.91Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl. ( Acquadro, MA; Cheng, Y; Farah, F; Gerges, FJ; Kalaydjian, A, 2019)
"Microsphere bupivacaine released near the incision reduced the chronic tactile allodynia after thoracotomy."3.81Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres. ( Blaskovich, P; Ohri, R; Strichartz, GR; Wang, JC, 2015)
"Our studies showed that subcutaneous duloxetine (2 mg) reduced hyperalgesia and allodynia for several days after skin incision, whereas subcutaneous bupivacaine (2 mg) did not."3.81The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model. ( Russell, G; Strichartz, GR; Wang, CF; Wang, GK, 2015)
" The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats."3.76Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010)
" In this study, we evaluated the effect of bupivacaine administered via a nerve block or via a systemic route on the spinal expression of PGE2 and COX in a model of peripheral inflammation in rats."3.75The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. ( Beloeil, H; Benhamou, D; Gentili, M; Mazoit, JX, 2009)
" Following the unilateral intraplantar injection of BmK venom into rat hind paw, it was found: 1) BmK venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von Frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress BmK venom-induced pain responses with different intensity and time courses."3.73Rat pain-related responses induced by experimental scorpion BmK sting. ( Bai, ZT; Chai, ZF; Ji, YH; Liu, T; Pang, XY, 2006)
" Preincisional subcutaneous bupivacaine selectively suppresses and shortens allodynia for times far outlasting its local anesthesia, an effect largely from systemic actions."3.73Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. ( Duarte, AM; Hamaya, Y; Mujenda, F; Pospisilova, E; Reilly, E; Strichartz, GR, 2005)
"Different mechanisms underlie hyperalgesia localized at areas surrounding the site of pain and hyperalgesia generalized to distant body areas."2.71Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. ( Arendt-Nielsen, L; Curatolo, M; Di Stefano, G; Herren-Gerber, R; Petersen-Felix, S; Radanov, BP; Weiss, S, 2004)
"Mechanical hyperalgesia was measured by von Frey filaments."2.71The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. ( De Kock, M; Lavand'homme, P; Waterloos, H, 2005)
"Mechanical allodynia was assessed by withdrawal from application of von Frey filaments, and local tolerance was evaluated by histology."1.91Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain. ( Glass, CM; Heffernan, JM; McLaren, AC; Overstreet, DJ, 2023)
"At Day 1, partial reversal of mechanical allodynia in aboBoNT-A groups was followed by a full reversal from Day 3."1.72Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model. ( Carré, D; Castel, D; Cornet, S; Evans, S; Horne, R; Kalinichev, M; Lezmi, S; Limana, L; Meilin, S; Pons, L, 2022)
"The mechanical allodynia, thermal hyperalgesia and thermal allodynia was assessed by pain behavioral tests."1.62Low concentration of Bupivacaine ameliorates painful diabetic neuropathy by mediating miR-23a/PDE4B axis in microglia. ( Ju, F; Liao, O; Xia, L; Xie, A; Zhang, X; Zhou, Y, 2021)
"Chronic neuropathic pain following traumatic brachial plexus injury could be successfully managed by chemical neurolysis and oral gabapentin."1.51Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report. ( Aaron, OI; Adetoye, AO; Orimolade, EA; P Adetifa, KA, 2019)
"Bupivacaine was steadily released as measured in vitro over 35 days."1.48Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. ( Dai, F; Hurwitz, O; LaMotte, RH; Ma, C; Shimada, SG; Tian, D; Wang, T; Zhou, J, 2018)
" Formulations of Gelfoam® and BP-PLGA microparticles (GelBP), with three targeted dosing profiles (0."1.48A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. ( Haines, LG; Harrington, JM; Johnson, LM; Nackley, AG; O'Buckley, SC; Rothrock, GD; Shepherd, SD, 2018)
"The opioid-induced hyperalgesia may occur in early postoperative period."1.43[THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD]. ( Dmytriyev, DV, 2016)
"Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia."1.42Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats. ( Brennan, TJ; Dalm, BD; Howard, MA; Kang, S; Reddy, CG, 2015)
"Subsequently, sufentanil induced hyperalgesia in diabetic and non-diabetic mice."1.42Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice. ( Blaes, N; Fourcade, O; Francès, B; Girolami, JP; Gomez-Brouchet, A; Minville, V; Mouledous, L; Tack, I, 2015)
"There was "rebound hyperalgesia" to thermal stimulus after the resolution of plain bupivacaine sciatic nerve block."1.42Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. ( An, K; Elkassabany, NM; Liu, J, 2015)
"Levobupivacaine was more potent than lidocaine in all tests employed on diabetic rats."1.39Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. ( Gunay, I; Gunes, Y; Mert, T, 2013)
"Acute postoperative pain causes physiological deficits and slows recovery."1.39Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. ( Blaskovich, PD; Costa, DS; Herman, CJ; Hildebrand, WP; Nichols, GA; Ohri, R; Pham, LN; Scarborough, NL; Strichartz, GR; Wang, JC, 2013)
"Tricyclic antidepressants (TCA) have potent local anesthetic properties and may produce a long-lasting pain blockade that could be of interest in relieving chronic pain states such as neuropathic pain, but there are only few data comparing their dose-response curves of analgesic activity under the same experimental conditions."1.36Analgesic and antiallodynic effects of antidepressants after infiltration into the rat. ( del Valle, J; Domenech, J; Escribano, E; Garcia, X; Queralt, J, 2010)
"Thermal hyperalgesia was assessed daily from day 1 to day 10 after UVA-light exposure by measuring response latency to noxious heat (tail immersion in 49 degrees C water)."1.34Pre-emptive ring-block with bupivacaine prevents the development of thermal hyperalgesia, but not sustained mechanical hyperalgesia, in rat tails exposed to ultraviolet A light. ( Kamerman, P; Mitchell, D; Themistocleous, A, 2007)
"The incisional allodynia and the carrageenan-induced hyperalgesia were intensified by the microinjection of 2% lidocaine into the contralateral, but not ipsilateral APtN, the effect being significantly stronger when a large incision or a higher carrageenan concentration was utilized."1.32Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat. ( Del Bel, EA; Prado, WA; Villarreal, CF, 2003)
"Bupivacaine microspheres treatment produced conduction blockade with a complete lack of sensory responsiveness in the sural territory for 6 to 10 days."1.32Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. ( Berde, CB; Decosterd, I; Gilliard, N; Papaloïzos, M; Spahn, DR; Suter, MR; Woolf, CJ, 2003)
"Bupivacaine (1."1.32Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation. ( Ecoffey, C; Estebe, JP; Gentili, ME; Le Corre, P; Leduc, C; Moulinoux, JP, 2004)
"Secondary hyperalgesia, an exaggerated response to stimuli applied to undamaged tissue surrounding an injury, is a common consequence of tissue injury and inflammation."1.31Persistent secondary hyperalgesia after gastrocnemius incision in the rat. ( Brennan, TJ; Niemeier, JS; Pogatzki, EM, 2002)
"Inflammatory hyperalgesia was completely prevented by the precarrageenan injection of RTX."1.31Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity. ( Bradley, EL; Bright, CA; Kissin, I, 2002)
"Hyperalgesia was persistent through 2 days after surgery and then gradually returned toward preincision values over the next 4 days."1.30Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain. ( Brennan, TJ; Umali, EF; Zahn, PK, 1997)
"The resulting hyperalgesia to radiant heat and spontaneous nociceptive behaviors was assessed by using a foot-withdrawal test and a spontaneous pain behavior rating method, respectively."1.28Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (16.00)18.2507
2000's21 (42.00)29.6817
2010's17 (34.00)24.3611
2020's4 (8.00)2.80

Authors

AuthorsStudies
Wu, CC1
Chang, CY1
Tzeng, CY1
Huang, JH1
Hung, CJ1
Chen, WY1
Liao, SL1
Kuan, YH1
Chen, CJ1
Heffernan, JM1
McLaren, AC1
Glass, CM1
Overstreet, DJ1
Cornet, S2
Carré, D2
Limana, L2
Castel, D2
Meilin, S2
Horne, R2
Pons, L2
Evans, S2
Lezmi, S2
Kalinichev, M2
Adetoye, AO1
Aaron, OI1
Orimolade, EA1
P Adetifa, KA1
Zhang, X1
Xia, L1
Xie, A1
Liao, O1
Ju, F1
Zhou, Y1
Ji, ZH1
Liu, ZJ1
Liu, ZT1
Zhao, W1
Williams, BA1
Zhang, HF1
Li, L1
Xu, SY1
Wang, T1
Hurwitz, O1
Shimada, SG1
Tian, D1
Dai, F1
Zhou, J1
Ma, C1
LaMotte, RH1
Shepherd, SD1
O'Buckley, SC1
Harrington, JM1
Haines, LG1
Rothrock, GD1
Johnson, LM1
Nackley, AG1
Kalaydjian, A1
Farah, F1
Cheng, Y1
Acquadro, MA1
Gerges, FJ1
Ohri, R2
Wang, JC2
Blaskovich, PD1
Pham, LN1
Costa, DS1
Nichols, GA1
Hildebrand, WP1
Scarborough, NL1
Herman, CJ1
Strichartz, GR4
An, K1
Elkassabany, NM1
Liu, J1
Blaskovich, P1
Wang, CF1
Russell, G1
Wang, GK1
Gomez-Brouchet, A1
Blaes, N1
Mouledous, L1
Fourcade, O1
Tack, I1
Francès, B1
Girolami, JP1
Minville, V1
Clifford, JL1
Mares, A1
Hansen, J1
Averitt, DL1
Dalm, BD1
Reddy, CG1
Howard, MA1
Kang, S1
Brennan, TJ5
Dmytriyev, DV1
Campos, CR1
Ocheltree, SM1
Hom, S1
Egleton, RD1
Davis, TP1
Xu, J1
Rodriguez-Navarro, AJ1
Lagos, M1
Figueroa, C1
Garcia, C1
Recabal, P1
Silva, P1
Iglesias, V1
Lagos, N1
Beloeil, H2
Gentili, M1
Benhamou, D2
Mazoit, JX2
Combettes, E1
Garcia, X1
del Valle, J1
Escribano, E1
Domenech, J1
Queralt, J1
Mert, T1
Gunes, Y1
Gunay, I1
Birkelund, T1
Revenfeld, TS1
Møller, JF1
Pogatzki, EM2
Niemeier, JS1
Villarreal, CF1
Del Bel, EA1
Prado, WA1
Jasmin, L1
Rabkin, SD1
Granato, A1
Boudah, A1
Ohara, PT1
Hasirci, V1
Bonney, I1
Goudas, LC1
Shuster, L1
Carr, DB1
Wise, DL1
Suter, MR1
Papaloïzos, M1
Berde, CB1
Woolf, CJ1
Gilliard, N1
Spahn, DR1
Decosterd, I1
Estebe, JP1
Gentili, ME1
Le Corre, P1
Leduc, C1
Moulinoux, JP1
Ecoffey, C1
Herren-Gerber, R1
Weiss, S1
Arendt-Nielsen, L1
Petersen-Felix, S1
Di Stefano, G1
Radanov, BP1
Curatolo, M1
Xie, W1
Strong, JA1
Meij, JTA1
Zhang, JM2
Yu, L1
Duarte, AM1
Pospisilova, E1
Reilly, E1
Mujenda, F1
Hamaya, Y1
De Kock, M1
Lavand'homme, P1
Waterloos, H1
Bai, ZT1
Liu, T1
Chai, ZF1
Pang, XY1
Ji, YH1
Themistocleous, A1
Kamerman, P1
Mitchell, D1
Ayesh, EE1
Ernberg, M1
Svensson, P1
Cadet, R2
Aigouy, L2
Woda, A2
Christie, JM1
Chen, GW1
Brennum, J1
Umali, EF1
Zahn, PK1
De Lima, J1
Alvares, D1
Hatch, DJ1
Fitzgerald, M1
Fu, KY1
Light, AR1
Maixner, W1
Homma, Y1
Ackerman, WE1
Brull, SJ1
Kissin, I1
Bright, CA1
Bradley, EL1
Vandermeulen, EP1
Mao, J1
Price, DD1
Mayer, DJ1
Lu, J1
Hayes, RL1
Raja, SN1
Treede, RD1
Davis, KD1
Campbell, JN1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparative Study Between Dexamethasone, and Dexmedetomidine as Additives to Bupivacaine in Ultrasound Guided Adductor Canal Block in Knee Arthroscopy[NCT04631822]42 participants (Anticipated)Interventional2021-01-01Not yet recruiting
Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty: A Double Blind Randomized Study[NCT03025594]Phase 364 participants (Anticipated)Interventional2017-01-31Recruiting
The Evaluation Of The Efficacy Of Auriculotemporal Nerve Block In Temporomandibular Disorders[NCT04827784]22 participants (Actual)Interventional2020-01-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

6 trials available for bupivacaine and Allodynia

ArticleYear
Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: development of a long-acting pain blocker.
    Neurotoxicity research, 2009, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug

2009
Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury.
    Pain medicine (Malden, Mass.), 2004, Volume: 5, Issue:4

    Topics: Adult; Bupivacaine; Chronic Disease; Female; Humans; Hyperalgesia; Male; Middle Aged; Neck Muscles;

2004
The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:2

    Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Anest

2005
Effects of local anesthetics on somatosensory function in the temporomandibular joint area.
    Experimental brain research, 2007, Volume: 180, Issue:4

    Topics: Adult; Anesthetics, Local; Arthralgia; Bupivacaine; Double-Blind Method; Female; Humans; Hyperalgesi

2007
Secondary hyperalgesia is not affected by wound infiltration with bupivacaine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:11

    Topics: Adult; Analgesia, Obstetrical; Bupivacaine; Cesarean Section; Double-Blind Method; Female; Humans; H

1993
Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain.
    Anesthesiology, 1991, Volume: 74, Issue:4

    Topics: Adult; Bupivacaine; Chronic Disease; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Hemodyn

1991

Other Studies

44 other studies available for bupivacaine and Allodynia

ArticleYear
Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury.
    International journal of molecular sciences, 2022, Jun-28, Volume: 23, Issue:13

    Topics: Animals; Bupivacaine; Constriction; Crush Injuries; Cytokines; HMGB1 Protein; Hyperalgesia; Injectio

2022
Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain.
    Pain medicine (Malden, Mass.), 2023, 02-01, Volume: 24, Issue:2

    Topics: Acrylamides; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Hydrogels; Hyperalgesia; Meloxicam

2023
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
    Scientific reports, 2022, 12-13, Volume: 12, Issue:1

    Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia,

2022
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
    Scientific reports, 2022, 12-13, Volume: 12, Issue:1

    Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia,

2022
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
    Scientific reports, 2022, 12-13, Volume: 12, Issue:1

    Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia,

2022
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
    Scientific reports, 2022, 12-13, Volume: 12, Issue:1

    Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia,

2022
Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report.
    Nigerian journal of clinical practice, 2019, Volume: 22, Issue:9

    Topics: Adult; Aged; Analgesics; Brachial Plexus; Brachial Plexus Neuropathies; Bupivacaine; Gabapentin; Hum

2019
Low concentration of Bupivacaine ameliorates painful diabetic neuropathy by mediating miR-23a/PDE4B axis in microglia.
    European journal of pharmacology, 2021, Jan-15, Volume: 891

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Blood Glucose; Bupivacaine; Cerebral Cortex; Cyclic N

2021
Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:2

    Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetic Neuropathies; Electrophysiology; Enzyme Inhibitor

2017
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.
    Neuroscience letters, 2018, 03-06, Volume: 668

    Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Lac

2018
A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain.
    Scientific reports, 2018, 08-15, Volume: 8, Issue:1

    Topics: Analgesics; Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Drug Compounding;

2018
Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl.
    Pain practice : the official journal of World Institute of Pain, 2019, Volume: 19, Issue:2

    Topics: Analgesics, Opioid; Bupivacaine; Female; Fentanyl; Humans; Hyperalgesia; Infusion Pumps, Implantable

2019
Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision.
    Anesthesia and analgesia, 2013, Volume: 117, Issue:3

    Topics: Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Data Interpretation,

2013
Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Anesthetics, Local; Animals; Axons; Bupivacaine; Chemotherapy, Adjuvant; Dexamethasone; Disease Mode

2015
Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres.
    Anesthesia and analgesia, 2015, Volume: 120, Issue:6

    Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Drug Administration Schedule;

2015
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
    Anesthesia and analgesia, 2015, Volume: 121, Issue:2

    Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Cells, Cultured; De

2015
Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice.
    Journal of translational medicine, 2015, Jul-02, Volume: 13

    Topics: Analgesics, Opioid; Anesthesia, Conduction; Animals; Bupivacaine; Diabetes Mellitus, Experimental; H

2015
Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model.
    BMC anesthesiology, 2015, Oct-06, Volume: 15

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cold Temperature; Hyperalgesia; Ligation; Male; Rats; Rats

2015
Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Conditioning, Psychological; Disease Mod

2015
[THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD].
    Klinichna khirurhiia, 2016, Issue:1

    Topics: Abdominal Neoplasms; Adolescent; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Spinal; Anest

2016
Nociceptive inhibition prevents inflammatory pain induced changes in the blood-brain barrier.
    Brain research, 2008, Jul-24, Volume: 1221

    Topics: Anesthetics, Local; Animals; Blood-Brain Barrier; Brain Edema; Bupivacaine; Carrageenan; Claudin-5;

2008
Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neurons.
    Pain, 2009, Volume: 144, Issue:3

    Topics: Action Potentials; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Dermatologic Surgical

2009
The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:3

    Topics: Animals; Bupivacaine; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Edema; Gene Expression Regul

2009
Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:7

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Dinoprostone; Dis

2010
Analgesic and antiallodynic effects of antidepressants after infiltration into the rat.
    Pharmacology, 2010, Volume: 86, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Analgesics; Anesthetics, Local; Animals; Antidepressive Agents, Tricyc

2010
Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:2

    Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Disease Models, Animal; F

2013
[Transient segmental hyperalgesia following epidural analgesia].
    Ugeskrift for laeger, 2012, May-21, Volume: 174, Issue:21

    Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Di

2012
Persistent secondary hyperalgesia after gastrocnemius incision in the rat.
    European journal of pain (London, England), 2002, Volume: 6, Issue:4

    Topics: Anesthetics, Local; Animals; Bupivacaine; Hindlimb; Hot Temperature; Hyperalgesia; Lidocaine; Male;

2002
Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat.
    Pain, 2003, Volume: 103, Issue:1-2

    Topics: Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Dose-Response Relatio

2003
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
    Nature, 2003, Jul-17, Volume: 424, Issue:6946

    Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge

2003
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
    Life sciences, 2003, Nov-14, Volume: 73, Issue:26

    Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug;

2003
Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block.
    Anesthesiology, 2003, Volume: 99, Issue:6

    Topics: Animals; Bupivacaine; Hyperalgesia; Male; Nerve Block; Pain Management; Peripheral Nerve Injuries; R

2003
Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.
    British journal of anaesthesia, 2004, Volume: 93, Issue:5

    Topics: Amitriptyline; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Hypera

2004
Neuropathic pain: early spontaneous afferent activity is the trigger.
    Pain, 2005, Volume: 116, Issue:3

    Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Axotomy; Behavior, Animal; Bup

2005
Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Animals; Bupivacaine; Hair Follicle; Hyperalgesia; Injections, Subcutaneous; Male; Pain Measurement;

2005
Rat pain-related responses induced by experimental scorpion BmK sting.
    European journal of pharmacology, 2006, Dec-15, Volume: 552, Issue:1-3

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain

2006
Pre-emptive ring-block with bupivacaine prevents the development of thermal hyperalgesia, but not sustained mechanical hyperalgesia, in rat tails exposed to ultraviolet A light.
    The journal of pain, 2007, Volume: 8, Issue:3

    Topics: Analysis of Variance; Animals; Bupivacaine; Hyperalgesia; Male; Nerve Block; Nerve Fibers, Unmyelina

2007
Enhanced nociceptive behaviour following conditioning injection of formalin in the perioral area of the rat.
    Brain research, 1995, Apr-03, Volume: 676, Issue:1

    Topics: Animals; Bupivacaine; Conditioning, Psychological; Formaldehyde; Functional Laterality; Hyperalgesia

1995
Sustained hyperalgesia can be induced in the rat by a single formalin injection and depends on the initial nociceptive inputs.
    Neuroscience letters, 1993, Jun-25, Volume: 156, Issue:1-2

    Topics: Analysis of Variance; Animals; Bupivacaine; Formaldehyde; Hyperalgesia; Lip; Male; Nociceptors; Rats

1993
Quantitative sensory examination of epidural anaesthesia and analgesia in man.
    Acta physiologica Scandinavica. Supplementum, 1996, Volume: 634

    Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Evok

1996
Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain.
    Anesthesiology, 1997, Volume: 87, Issue:6

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Bupivacaine; Hyperalgesia; Injections, Spinal; Male

1997
Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block.
    British journal of anaesthesia, 1999, Volume: 83, Issue:4

    Topics: Anesthetics, Local; Animals; Animals, Newborn; Bupivacaine; Hyperalgesia; Nerve Block; Rats; Rats, S

1999
Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin.
    Neuroscience, 2000, Volume: 101, Issue:4

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Chronic Disease; Dose-Response Relations

2000
Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:2

    Topics: Administration, Topical; Animals; Bupivacaine; Ganglia, Spinal; Hydrogen-Ion Concentration; Hyperalg

2001
Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:5

    Topics: Animals; Bupivacaine; Capsaicin; Carrageenan; Diterpenes; Hyperalgesia; Male; Nerve Block; Periphera

2002
Effect of plantar local anesthetic injection on dorsal horn neuron activity and pain behaviors caused by incision.
    Pain, 2002, Volume: 97, Issue:1-2

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Electrophysiology; Hindlimb; Hyperalgesi

2002
Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.
    Brain research, 1992, Apr-03, Volume: 576, Issue:2

    Topics: Anesthesia, Local; Animals; Bupivacaine; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism

1992