bupivacaine has been researched along with Allodynia in 50 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Excerpt | Relevance | Reference |
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" The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats." | 7.76 | Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010) |
" Preincisional subcutaneous bupivacaine selectively suppresses and shortens allodynia for times far outlasting its local anesthesia, an effect largely from systemic actions." | 7.73 | Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. ( Duarte, AM; Hamaya, Y; Mujenda, F; Pospisilova, E; Reilly, E; Strichartz, GR, 2005) |
"Rats exhibited both mechanical and cold allodynia, but not thermal hyperalgesia, within 3 days and up to 21 days post-SNL." | 5.42 | Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model. ( Averitt, DL; Clifford, JL; Hansen, J; Mares, A, 2015) |
"Acute postoperative pain causes physiological deficits and slows recovery." | 5.39 | Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. ( Blaskovich, PD; Costa, DS; Herman, CJ; Hildebrand, WP; Nichols, GA; Ohri, R; Pham, LN; Scarborough, NL; Strichartz, GR; Wang, JC, 2013) |
"We report the case of a 60 year old patient on chronic Intrathecal combined fentanyl and Bupivacaine who had worsening pain with increasing doses and improved after weaning off intrathecal opioids." | 3.91 | Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl. ( Acquadro, MA; Cheng, Y; Farah, F; Gerges, FJ; Kalaydjian, A, 2019) |
"Microsphere bupivacaine released near the incision reduced the chronic tactile allodynia after thoracotomy." | 3.81 | Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres. ( Blaskovich, P; Ohri, R; Strichartz, GR; Wang, JC, 2015) |
"Our studies showed that subcutaneous duloxetine (2 mg) reduced hyperalgesia and allodynia for several days after skin incision, whereas subcutaneous bupivacaine (2 mg) did not." | 3.81 | The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model. ( Russell, G; Strichartz, GR; Wang, CF; Wang, GK, 2015) |
" The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats." | 3.76 | Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010) |
" In this study, we evaluated the effect of bupivacaine administered via a nerve block or via a systemic route on the spinal expression of PGE2 and COX in a model of peripheral inflammation in rats." | 3.75 | The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. ( Beloeil, H; Benhamou, D; Gentili, M; Mazoit, JX, 2009) |
" Following the unilateral intraplantar injection of BmK venom into rat hind paw, it was found: 1) BmK venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von Frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress BmK venom-induced pain responses with different intensity and time courses." | 3.73 | Rat pain-related responses induced by experimental scorpion BmK sting. ( Bai, ZT; Chai, ZF; Ji, YH; Liu, T; Pang, XY, 2006) |
" Preincisional subcutaneous bupivacaine selectively suppresses and shortens allodynia for times far outlasting its local anesthesia, an effect largely from systemic actions." | 3.73 | Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. ( Duarte, AM; Hamaya, Y; Mujenda, F; Pospisilova, E; Reilly, E; Strichartz, GR, 2005) |
"Different mechanisms underlie hyperalgesia localized at areas surrounding the site of pain and hyperalgesia generalized to distant body areas." | 2.71 | Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. ( Arendt-Nielsen, L; Curatolo, M; Di Stefano, G; Herren-Gerber, R; Petersen-Felix, S; Radanov, BP; Weiss, S, 2004) |
"Mechanical hyperalgesia was measured by von Frey filaments." | 2.71 | The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. ( De Kock, M; Lavand'homme, P; Waterloos, H, 2005) |
"Mechanical allodynia was assessed by withdrawal from application of von Frey filaments, and local tolerance was evaluated by histology." | 1.91 | Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain. ( Glass, CM; Heffernan, JM; McLaren, AC; Overstreet, DJ, 2023) |
"At Day 1, partial reversal of mechanical allodynia in aboBoNT-A groups was followed by a full reversal from Day 3." | 1.72 | Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model. ( Carré, D; Castel, D; Cornet, S; Evans, S; Horne, R; Kalinichev, M; Lezmi, S; Limana, L; Meilin, S; Pons, L, 2022) |
"The mechanical allodynia, thermal hyperalgesia and thermal allodynia was assessed by pain behavioral tests." | 1.62 | Low concentration of Bupivacaine ameliorates painful diabetic neuropathy by mediating miR-23a/PDE4B axis in microglia. ( Ju, F; Liao, O; Xia, L; Xie, A; Zhang, X; Zhou, Y, 2021) |
"Chronic neuropathic pain following traumatic brachial plexus injury could be successfully managed by chemical neurolysis and oral gabapentin." | 1.51 | Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report. ( Aaron, OI; Adetoye, AO; Orimolade, EA; P Adetifa, KA, 2019) |
"Bupivacaine was steadily released as measured in vitro over 35 days." | 1.48 | Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. ( Dai, F; Hurwitz, O; LaMotte, RH; Ma, C; Shimada, SG; Tian, D; Wang, T; Zhou, J, 2018) |
" Formulations of Gelfoam® and BP-PLGA microparticles (GelBP), with three targeted dosing profiles (0." | 1.48 | A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. ( Haines, LG; Harrington, JM; Johnson, LM; Nackley, AG; O'Buckley, SC; Rothrock, GD; Shepherd, SD, 2018) |
"The opioid-induced hyperalgesia may occur in early postoperative period." | 1.43 | [THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD]. ( Dmytriyev, DV, 2016) |
"Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia." | 1.42 | Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats. ( Brennan, TJ; Dalm, BD; Howard, MA; Kang, S; Reddy, CG, 2015) |
"Subsequently, sufentanil induced hyperalgesia in diabetic and non-diabetic mice." | 1.42 | Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice. ( Blaes, N; Fourcade, O; Francès, B; Girolami, JP; Gomez-Brouchet, A; Minville, V; Mouledous, L; Tack, I, 2015) |
"There was "rebound hyperalgesia" to thermal stimulus after the resolution of plain bupivacaine sciatic nerve block." | 1.42 | Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. ( An, K; Elkassabany, NM; Liu, J, 2015) |
"Levobupivacaine was more potent than lidocaine in all tests employed on diabetic rats." | 1.39 | Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. ( Gunay, I; Gunes, Y; Mert, T, 2013) |
"Acute postoperative pain causes physiological deficits and slows recovery." | 1.39 | Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. ( Blaskovich, PD; Costa, DS; Herman, CJ; Hildebrand, WP; Nichols, GA; Ohri, R; Pham, LN; Scarborough, NL; Strichartz, GR; Wang, JC, 2013) |
"Tricyclic antidepressants (TCA) have potent local anesthetic properties and may produce a long-lasting pain blockade that could be of interest in relieving chronic pain states such as neuropathic pain, but there are only few data comparing their dose-response curves of analgesic activity under the same experimental conditions." | 1.36 | Analgesic and antiallodynic effects of antidepressants after infiltration into the rat. ( del Valle, J; Domenech, J; Escribano, E; Garcia, X; Queralt, J, 2010) |
"Thermal hyperalgesia was assessed daily from day 1 to day 10 after UVA-light exposure by measuring response latency to noxious heat (tail immersion in 49 degrees C water)." | 1.34 | Pre-emptive ring-block with bupivacaine prevents the development of thermal hyperalgesia, but not sustained mechanical hyperalgesia, in rat tails exposed to ultraviolet A light. ( Kamerman, P; Mitchell, D; Themistocleous, A, 2007) |
"The incisional allodynia and the carrageenan-induced hyperalgesia were intensified by the microinjection of 2% lidocaine into the contralateral, but not ipsilateral APtN, the effect being significantly stronger when a large incision or a higher carrageenan concentration was utilized." | 1.32 | Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat. ( Del Bel, EA; Prado, WA; Villarreal, CF, 2003) |
"Bupivacaine microspheres treatment produced conduction blockade with a complete lack of sensory responsiveness in the sural territory for 6 to 10 days." | 1.32 | Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. ( Berde, CB; Decosterd, I; Gilliard, N; Papaloïzos, M; Spahn, DR; Suter, MR; Woolf, CJ, 2003) |
"Bupivacaine (1." | 1.32 | Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation. ( Ecoffey, C; Estebe, JP; Gentili, ME; Le Corre, P; Leduc, C; Moulinoux, JP, 2004) |
"Secondary hyperalgesia, an exaggerated response to stimuli applied to undamaged tissue surrounding an injury, is a common consequence of tissue injury and inflammation." | 1.31 | Persistent secondary hyperalgesia after gastrocnemius incision in the rat. ( Brennan, TJ; Niemeier, JS; Pogatzki, EM, 2002) |
"Inflammatory hyperalgesia was completely prevented by the precarrageenan injection of RTX." | 1.31 | Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity. ( Bradley, EL; Bright, CA; Kissin, I, 2002) |
"Hyperalgesia was persistent through 2 days after surgery and then gradually returned toward preincision values over the next 4 days." | 1.30 | Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain. ( Brennan, TJ; Umali, EF; Zahn, PK, 1997) |
"The resulting hyperalgesia to radiant heat and spontaneous nociceptive behaviors was assessed by using a foot-withdrawal test and a spontaneous pain behavior rating method, respectively." | 1.28 | Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 8 (16.00) | 18.2507 |
2000's | 21 (42.00) | 29.6817 |
2010's | 17 (34.00) | 24.3611 |
2020's | 4 (8.00) | 2.80 |
Authors | Studies |
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Wu, CC | 1 |
Chang, CY | 1 |
Tzeng, CY | 1 |
Huang, JH | 1 |
Hung, CJ | 1 |
Chen, WY | 1 |
Liao, SL | 1 |
Kuan, YH | 1 |
Chen, CJ | 1 |
Heffernan, JM | 1 |
McLaren, AC | 1 |
Glass, CM | 1 |
Overstreet, DJ | 1 |
Cornet, S | 2 |
Carré, D | 2 |
Limana, L | 2 |
Castel, D | 2 |
Meilin, S | 2 |
Horne, R | 2 |
Pons, L | 2 |
Evans, S | 2 |
Lezmi, S | 2 |
Kalinichev, M | 2 |
Adetoye, AO | 1 |
Aaron, OI | 1 |
Orimolade, EA | 1 |
P Adetifa, KA | 1 |
Zhang, X | 1 |
Xia, L | 1 |
Xie, A | 1 |
Liao, O | 1 |
Ju, F | 1 |
Zhou, Y | 1 |
Ji, ZH | 1 |
Liu, ZJ | 1 |
Liu, ZT | 1 |
Zhao, W | 1 |
Williams, BA | 1 |
Zhang, HF | 1 |
Li, L | 1 |
Xu, SY | 1 |
Wang, T | 1 |
Hurwitz, O | 1 |
Shimada, SG | 1 |
Tian, D | 1 |
Dai, F | 1 |
Zhou, J | 1 |
Ma, C | 1 |
LaMotte, RH | 1 |
Shepherd, SD | 1 |
O'Buckley, SC | 1 |
Harrington, JM | 1 |
Haines, LG | 1 |
Rothrock, GD | 1 |
Johnson, LM | 1 |
Nackley, AG | 1 |
Kalaydjian, A | 1 |
Farah, F | 1 |
Cheng, Y | 1 |
Acquadro, MA | 1 |
Gerges, FJ | 1 |
Ohri, R | 2 |
Wang, JC | 2 |
Blaskovich, PD | 1 |
Pham, LN | 1 |
Costa, DS | 1 |
Nichols, GA | 1 |
Hildebrand, WP | 1 |
Scarborough, NL | 1 |
Herman, CJ | 1 |
Strichartz, GR | 4 |
An, K | 1 |
Elkassabany, NM | 1 |
Liu, J | 1 |
Blaskovich, P | 1 |
Wang, CF | 1 |
Russell, G | 1 |
Wang, GK | 1 |
Gomez-Brouchet, A | 1 |
Blaes, N | 1 |
Mouledous, L | 1 |
Fourcade, O | 1 |
Tack, I | 1 |
Francès, B | 1 |
Girolami, JP | 1 |
Minville, V | 1 |
Clifford, JL | 1 |
Mares, A | 1 |
Hansen, J | 1 |
Averitt, DL | 1 |
Dalm, BD | 1 |
Reddy, CG | 1 |
Howard, MA | 1 |
Kang, S | 1 |
Brennan, TJ | 5 |
Dmytriyev, DV | 1 |
Campos, CR | 1 |
Ocheltree, SM | 1 |
Hom, S | 1 |
Egleton, RD | 1 |
Davis, TP | 1 |
Xu, J | 1 |
Rodriguez-Navarro, AJ | 1 |
Lagos, M | 1 |
Figueroa, C | 1 |
Garcia, C | 1 |
Recabal, P | 1 |
Silva, P | 1 |
Iglesias, V | 1 |
Lagos, N | 1 |
Beloeil, H | 2 |
Gentili, M | 1 |
Benhamou, D | 2 |
Mazoit, JX | 2 |
Combettes, E | 1 |
Garcia, X | 1 |
del Valle, J | 1 |
Escribano, E | 1 |
Domenech, J | 1 |
Queralt, J | 1 |
Mert, T | 1 |
Gunes, Y | 1 |
Gunay, I | 1 |
Birkelund, T | 1 |
Revenfeld, TS | 1 |
Møller, JF | 1 |
Pogatzki, EM | 2 |
Niemeier, JS | 1 |
Villarreal, CF | 1 |
Del Bel, EA | 1 |
Prado, WA | 1 |
Jasmin, L | 1 |
Rabkin, SD | 1 |
Granato, A | 1 |
Boudah, A | 1 |
Ohara, PT | 1 |
Hasirci, V | 1 |
Bonney, I | 1 |
Goudas, LC | 1 |
Shuster, L | 1 |
Carr, DB | 1 |
Wise, DL | 1 |
Suter, MR | 1 |
Papaloïzos, M | 1 |
Berde, CB | 1 |
Woolf, CJ | 1 |
Gilliard, N | 1 |
Spahn, DR | 1 |
Decosterd, I | 1 |
Estebe, JP | 1 |
Gentili, ME | 1 |
Le Corre, P | 1 |
Leduc, C | 1 |
Moulinoux, JP | 1 |
Ecoffey, C | 1 |
Herren-Gerber, R | 1 |
Weiss, S | 1 |
Arendt-Nielsen, L | 1 |
Petersen-Felix, S | 1 |
Di Stefano, G | 1 |
Radanov, BP | 1 |
Curatolo, M | 1 |
Xie, W | 1 |
Strong, JA | 1 |
Meij, JTA | 1 |
Zhang, JM | 2 |
Yu, L | 1 |
Duarte, AM | 1 |
Pospisilova, E | 1 |
Reilly, E | 1 |
Mujenda, F | 1 |
Hamaya, Y | 1 |
De Kock, M | 1 |
Lavand'homme, P | 1 |
Waterloos, H | 1 |
Bai, ZT | 1 |
Liu, T | 1 |
Chai, ZF | 1 |
Pang, XY | 1 |
Ji, YH | 1 |
Themistocleous, A | 1 |
Kamerman, P | 1 |
Mitchell, D | 1 |
Ayesh, EE | 1 |
Ernberg, M | 1 |
Svensson, P | 1 |
Cadet, R | 2 |
Aigouy, L | 2 |
Woda, A | 2 |
Christie, JM | 1 |
Chen, GW | 1 |
Brennum, J | 1 |
Umali, EF | 1 |
Zahn, PK | 1 |
De Lima, J | 1 |
Alvares, D | 1 |
Hatch, DJ | 1 |
Fitzgerald, M | 1 |
Fu, KY | 1 |
Light, AR | 1 |
Maixner, W | 1 |
Homma, Y | 1 |
Ackerman, WE | 1 |
Brull, SJ | 1 |
Kissin, I | 1 |
Bright, CA | 1 |
Bradley, EL | 1 |
Vandermeulen, EP | 1 |
Mao, J | 1 |
Price, DD | 1 |
Mayer, DJ | 1 |
Lu, J | 1 |
Hayes, RL | 1 |
Raja, SN | 1 |
Treede, RD | 1 |
Davis, KD | 1 |
Campbell, JN | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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Comparative Study Between Dexamethasone, and Dexmedetomidine as Additives to Bupivacaine in Ultrasound Guided Adductor Canal Block in Knee Arthroscopy[NCT04631822] | 42 participants (Anticipated) | Interventional | 2021-01-01 | Not yet recruiting | |||
Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty: A Double Blind Randomized Study[NCT03025594] | Phase 3 | 64 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
The Evaluation Of The Efficacy Of Auriculotemporal Nerve Block In Temporomandibular Disorders[NCT04827784] | 22 participants (Actual) | Interventional | 2020-01-15 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
6 trials available for bupivacaine and Allodynia
Article | Year |
---|---|
Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: development of a long-acting pain blocker.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug | 2009 |
Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury.
Topics: Adult; Bupivacaine; Chronic Disease; Female; Humans; Hyperalgesia; Male; Middle Aged; Neck Muscles; | 2004 |
The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery.
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Anest | 2005 |
Effects of local anesthetics on somatosensory function in the temporomandibular joint area.
Topics: Adult; Anesthetics, Local; Arthralgia; Bupivacaine; Double-Blind Method; Female; Humans; Hyperalgesi | 2007 |
Secondary hyperalgesia is not affected by wound infiltration with bupivacaine.
Topics: Adult; Analgesia, Obstetrical; Bupivacaine; Cesarean Section; Double-Blind Method; Female; Humans; H | 1993 |
Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain.
Topics: Adult; Bupivacaine; Chronic Disease; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Hemodyn | 1991 |
44 other studies available for bupivacaine and Allodynia
Article | Year |
---|---|
Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury.
Topics: Animals; Bupivacaine; Constriction; Crush Injuries; Cytokines; HMGB1 Protein; Hyperalgesia; Injectio | 2022 |
Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain.
Topics: Acrylamides; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Hydrogels; Hyperalgesia; Meloxicam | 2023 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.
Topics: Analgesics; Animals; Bupivacaine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, | 2022 |
Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report.
Topics: Adult; Aged; Analgesics; Brachial Plexus; Brachial Plexus Neuropathies; Bupivacaine; Gabapentin; Hum | 2019 |
Low concentration of Bupivacaine ameliorates painful diabetic neuropathy by mediating miR-23a/PDE4B axis in microglia.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Blood Glucose; Bupivacaine; Cerebral Cortex; Cyclic N | 2021 |
Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress.
Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetic Neuropathies; Electrophysiology; Enzyme Inhibitor | 2017 |
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Lac | 2018 |
A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain.
Topics: Analgesics; Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Drug Compounding; | 2018 |
Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl.
Topics: Analgesics, Opioid; Bupivacaine; Female; Fentanyl; Humans; Hyperalgesia; Infusion Pumps, Implantable | 2019 |
Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Data Interpretation, | 2013 |
Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model.
Topics: Anesthetics, Local; Animals; Axons; Bupivacaine; Chemotherapy, Adjuvant; Dexamethasone; Disease Mode | 2015 |
Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres.
Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Drug Administration Schedule; | 2015 |
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Cells, Cultured; De | 2015 |
Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Animals; Bupivacaine; Diabetes Mellitus, Experimental; H | 2015 |
Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cold Temperature; Hyperalgesia; Ligation; Male; Rats; Rats | 2015 |
Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Conditioning, Psychological; Disease Mod | 2015 |
[THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD].
Topics: Abdominal Neoplasms; Adolescent; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Spinal; Anest | 2016 |
Nociceptive inhibition prevents inflammatory pain induced changes in the blood-brain barrier.
Topics: Anesthetics, Local; Animals; Blood-Brain Barrier; Brain Edema; Bupivacaine; Carrageenan; Claudin-5; | 2008 |
Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Dermatologic Surgical | 2009 |
The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats.
Topics: Animals; Bupivacaine; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Edema; Gene Expression Regul | 2009 |
Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Dinoprostone; Dis | 2010 |
Analgesic and antiallodynic effects of antidepressants after infiltration into the rat.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Anesthetics, Local; Animals; Antidepressive Agents, Tricyc | 2010 |
Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy.
Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Disease Models, Animal; F | 2013 |
[Transient segmental hyperalgesia following epidural analgesia].
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Di | 2012 |
Persistent secondary hyperalgesia after gastrocnemius incision in the rat.
Topics: Anesthetics, Local; Animals; Bupivacaine; Hindlimb; Hot Temperature; Hyperalgesia; Lidocaine; Male; | 2002 |
Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat.
Topics: Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Dose-Response Relatio | 2003 |
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge | 2003 |
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block.
Topics: Animals; Bupivacaine; Hyperalgesia; Male; Nerve Block; Pain Management; Peripheral Nerve Injuries; R | 2003 |
Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.
Topics: Amitriptyline; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Hypera | 2004 |
Neuropathic pain: early spontaneous afferent activity is the trigger.
Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Axotomy; Behavior, Animal; Bup | 2005 |
Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat.
Topics: Animals; Bupivacaine; Hair Follicle; Hyperalgesia; Injections, Subcutaneous; Male; Pain Measurement; | 2005 |
Rat pain-related responses induced by experimental scorpion BmK sting.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain | 2006 |
Pre-emptive ring-block with bupivacaine prevents the development of thermal hyperalgesia, but not sustained mechanical hyperalgesia, in rat tails exposed to ultraviolet A light.
Topics: Analysis of Variance; Animals; Bupivacaine; Hyperalgesia; Male; Nerve Block; Nerve Fibers, Unmyelina | 2007 |
Enhanced nociceptive behaviour following conditioning injection of formalin in the perioral area of the rat.
Topics: Animals; Bupivacaine; Conditioning, Psychological; Formaldehyde; Functional Laterality; Hyperalgesia | 1995 |
Sustained hyperalgesia can be induced in the rat by a single formalin injection and depends on the initial nociceptive inputs.
Topics: Analysis of Variance; Animals; Bupivacaine; Formaldehyde; Hyperalgesia; Lip; Male; Nociceptors; Rats | 1993 |
Quantitative sensory examination of epidural anaesthesia and analgesia in man.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Evok | 1996 |
Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Bupivacaine; Hyperalgesia; Injections, Spinal; Male | 1997 |
Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Bupivacaine; Hyperalgesia; Nerve Block; Rats; Rats, S | 1999 |
Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Chronic Disease; Dose-Response Relations | 2000 |
Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat.
Topics: Administration, Topical; Animals; Bupivacaine; Ganglia, Spinal; Hydrogen-Ion Concentration; Hyperalg | 2001 |
Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity.
Topics: Animals; Bupivacaine; Capsaicin; Carrageenan; Diterpenes; Hyperalgesia; Male; Nerve Block; Periphera | 2002 |
Effect of plantar local anesthetic injection on dorsal horn neuron activity and pain behaviors caused by incision.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Electrophysiology; Hindlimb; Hyperalgesi | 2002 |
Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.
Topics: Anesthesia, Local; Animals; Bupivacaine; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism | 1992 |