Page last updated: 2024-12-05

myrtenol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Myrtenol is a monoterpene alcohol found in numerous plants, including rosemary, myrtle, and eucalyptus. It is a colorless liquid with a characteristic camphoraceous odor. Its synthesis can be achieved through various methods, including the dehydration of borneol and the reduction of myrtenal. Myrtenol has demonstrated biological activities such as antimicrobial, antioxidant, and anti-inflammatory effects. Research suggests that it may exhibit potential benefits for skin health, wound healing, and neurological disorders. Its unique structure and biological activities make it a subject of ongoing research, particularly in the fields of medicine, cosmetics, and flavoring. '

myrtenol: fragrance ingredient; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10582
CHEMBL ID443408
SCHEMBL ID155709
MeSH IDM0528485

Synonyms (45)

Synonym
bicyclo[3.1.1]hept-2-ene-2-methanol, 6,6-dimethyl-
bicyclo[3.1.1]hept-2-ene-2-methanol, 6,6-dimethyl-, (1s)-
6,6-dimethyl-2-oxymethylbicyclo[3.1.1]hept-2-ene
(+/-)-myrtenol
alpha-pinene-10-ol
6,6-dimethyl-2-(hydroxymethyl)bicyclo[3.1.1]hept-2-ene
6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
nsc-408846
pinen-10-ol, l-2-
nsc408846
myrtenol
2-pinen-10-ol
515-00-4
6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol
LMPR0102120022
( )-myrtenol
bicyclo(3.1.1)hept-2-ene-2-methanol, 6,6-dimethyl-, (1s)-
bicyclo(3.1.1)hept-2-ene-2-methanol, 6,6-dimethyl-
BMSE000555
2-hydroxymethyl-6,6-dimethylbicyclo(3.1.1)hept-2-ene
(-)-pin-2-ene-10-ol
6,6-dimethyl-2-hydroxymethylbicyclo(3.1.1)hept-2-ene
CHEMBL443408
AKOS000120271
nsc 408846
fema no. 3439
einecs 208-193-5
(1r)-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
(1r)-2-pinen-10-ol
(1r)-(-)-myrtenol
SCHEMBL155709
rac-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methanol
(-)-myrtenol, 97
(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methanol #
myrtenol (.alpha.-pinene-10-ol)
6,6-dimethyl-bicyclo[3,1,1]hept-2-ene-2-methanol
6,6-dimethyl-2-oxymethlybicyclo[1.1.3]-hept-2-ene (myrtenol)
J-012851
FT-0774002
DTXSID00862089
(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methanol
6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol
1056567-07-7
(6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl)methanol
Q15425810

Research Excerpts

Overview

Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. Myrtenol has multiple pharmacological activities.

ExcerptReferenceRelevance
"Myrtenol is a monoterpene with multiple pharmacological activities. "( Myrtenol protects against myocardial ischemia-reperfusion injury through antioxidant and anti-apoptotic dependent mechanisms.
Albuquerque-Júnior, RLC; Britto, RM; de Almeida, GKM; de Sá, LA; Dos Santos, FSM; Guatimosim, S; Jesus, ICG; Lauton-Santos, S; Mesquita, TRR; Miguel-Dos-Santos, R; Pereira-Filho, RN; Quintans-Júnior, LJ; Santos, PHD; Silva-Neto, JAD; Souza, DS; Vasconcelos, CML, 2018
)
3.37
"(-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. "( Gastroprotective effect of (-)-myrtenol against ethanol-induced acute gastric lesions: possible mechanisms.
Almeida Santos, F; Braga, MA; da Silva, FV; de Sousa, DP; Fernandes, Hde B; Nunes, PI; Oliveira, IS; Oliveira, Rde C; Rao, VS; Viana, AF; Viana, Dde A, 2016
)
1.28

Effects

Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects.

ExcerptReferenceRelevance
"Myrtenol has gained wide interest because of its pharmacological profiles, mainly for treatment of chronic diseases. "( Characterization of β-cyclodextrin/myrtenol complex and its protective effect against nociceptive behavior and cognitive impairment in a chronic musculoskeletal pain model.
Beserra Filho, JIA; Bezerra, DP; da Silva, SP; de Carvalho Neto, AG; de Carvalho, YMBG; de Souza Araújo, AA; de Souza Siqueira Quintans, J; Dos Anjos, KS; Dos Santos, BL; Heimfarth, L; Marreto, RN; Melo Coutinho, HD; Nunes, PS; Quintans-Júnior, LJ; Ribeiro, AM; Scotti, L; Scotti, MT; Serafini, MR, 2020
)
2.28
"Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects."( Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Cai, J; Huang, S; Tan, Z; Tian, Y; Wang, Z, 2021
)
2.79

Treatment

ExcerptReferenceRelevance
"Myrtenol treatment notably decreased the status of blood glucose and lipid profile and improved the HDL in the GDM rats."( Myrtenol alleviates oxidative stress and inflammation in diabetic pregnant rats via TLR4/MyD88/NF-κB signaling pathway.
Chen, G; Liu, M; Qiu, S; Xuemei, L, 2021
)
2.79
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (1)

PathwayProteinsCompounds
Limonene and Pinene Degradation210

Bioassays (5)

Assay IDTitleYearJournalArticle
AID344008Antiproliferative activity against human PC3 cells assessed as reduction of cell viability at 400 uM after 72 hrs by WST-1 assay2008Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells.
AID344010Antiproliferative activity against human HL60 cells at 400 uM by WST-1 assay2008Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells.
AID344009Antiproliferative activity against human HL60 cells by WST-1 assay2008Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells.
AID1066527Antiinflammatory activity against human primary chondrocytes assessed as inhibition of IL-1beta-induced NO production at 10 to 25 ug/ml after 30 mins by Griess method2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Anti-inflammatory and chondroprotective activity of (+)-α-pinene: structural and enantiomeric selectivity.
AID344007Antiproliferative activity against human PC3 cells assessed as reduction of cell viability after 72 hrs by WST-1 assay relative to control2008Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (34)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (11.76)29.6817
2010's18 (52.94)24.3611
2020's12 (35.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.50 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index5.31 (4.65)
Search Engine Demand Index47.56 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (8.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (91.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]