Myrtenol is a monoterpene alcohol found in numerous plants, including rosemary, myrtle, and eucalyptus. It is a colorless liquid with a characteristic camphoraceous odor. Its synthesis can be achieved through various methods, including the dehydration of borneol and the reduction of myrtenal. Myrtenol has demonstrated biological activities such as antimicrobial, antioxidant, and anti-inflammatory effects. Research suggests that it may exhibit potential benefits for skin health, wound healing, and neurological disorders. Its unique structure and biological activities make it a subject of ongoing research, particularly in the fields of medicine, cosmetics, and flavoring. '
myrtenol: fragrance ingredient; structure in first source
ID Source | ID |
---|---|
PubMed CID | 10582 |
CHEMBL ID | 443408 |
SCHEMBL ID | 155709 |
MeSH ID | M0528485 |
Synonym |
---|
bicyclo[3.1.1]hept-2-ene-2-methanol, 6,6-dimethyl- |
bicyclo[3.1.1]hept-2-ene-2-methanol, 6,6-dimethyl-, (1s)- |
6,6-dimethyl-2-oxymethylbicyclo[3.1.1]hept-2-ene |
(+/-)-myrtenol |
alpha-pinene-10-ol |
6,6-dimethyl-2-(hydroxymethyl)bicyclo[3.1.1]hept-2-ene |
6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol |
nsc-408846 |
pinen-10-ol, l-2- |
nsc408846 |
myrtenol |
2-pinen-10-ol |
515-00-4 |
6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol |
LMPR0102120022 |
( )-myrtenol |
bicyclo(3.1.1)hept-2-ene-2-methanol, 6,6-dimethyl-, (1s)- |
bicyclo(3.1.1)hept-2-ene-2-methanol, 6,6-dimethyl- |
BMSE000555 |
2-hydroxymethyl-6,6-dimethylbicyclo(3.1.1)hept-2-ene |
(-)-pin-2-ene-10-ol |
6,6-dimethyl-2-hydroxymethylbicyclo(3.1.1)hept-2-ene |
CHEMBL443408 |
AKOS000120271 |
nsc 408846 |
fema no. 3439 |
einecs 208-193-5 |
(1r)-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol |
(1r)-2-pinen-10-ol |
(1r)-(-)-myrtenol |
SCHEMBL155709 |
rac-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methanol |
(-)-myrtenol, 97 |
(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methanol # |
myrtenol (.alpha.-pinene-10-ol) |
6,6-dimethyl-bicyclo[3,1,1]hept-2-ene-2-methanol |
6,6-dimethyl-2-oxymethlybicyclo[1.1.3]-hept-2-ene (myrtenol) |
J-012851 |
FT-0774002 |
DTXSID00862089 |
(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methanol |
6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol |
1056567-07-7 |
(6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl)methanol |
Q15425810 |
Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. Myrtenol has multiple pharmacological activities.
Excerpt | Reference | Relevance |
---|---|---|
"Myrtenol is a monoterpene with multiple pharmacological activities. " | ( Myrtenol protects against myocardial ischemia-reperfusion injury through antioxidant and anti-apoptotic dependent mechanisms. Albuquerque-Júnior, RLC; Britto, RM; de Almeida, GKM; de Sá, LA; Dos Santos, FSM; Guatimosim, S; Jesus, ICG; Lauton-Santos, S; Mesquita, TRR; Miguel-Dos-Santos, R; Pereira-Filho, RN; Quintans-Júnior, LJ; Santos, PHD; Silva-Neto, JAD; Souza, DS; Vasconcelos, CML, 2018) | 3.37 |
"(-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. " | ( Gastroprotective effect of (-)-myrtenol against ethanol-induced acute gastric lesions: possible mechanisms. Almeida Santos, F; Braga, MA; da Silva, FV; de Sousa, DP; Fernandes, Hde B; Nunes, PI; Oliveira, IS; Oliveira, Rde C; Rao, VS; Viana, AF; Viana, Dde A, 2016) | 1.28 |
Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects.
Excerpt | Reference | Relevance |
---|---|---|
"Myrtenol has gained wide interest because of its pharmacological profiles, mainly for treatment of chronic diseases. " | ( Characterization of β-cyclodextrin/myrtenol complex and its protective effect against nociceptive behavior and cognitive impairment in a chronic musculoskeletal pain model. Beserra Filho, JIA; Bezerra, DP; da Silva, SP; de Carvalho Neto, AG; de Carvalho, YMBG; de Souza Araújo, AA; de Souza Siqueira Quintans, J; Dos Anjos, KS; Dos Santos, BL; Heimfarth, L; Marreto, RN; Melo Coutinho, HD; Nunes, PS; Quintans-Júnior, LJ; Ribeiro, AM; Scotti, L; Scotti, MT; Serafini, MR, 2020) | 2.28 |
"Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects." | ( Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway. Cai, J; Huang, S; Tan, Z; Tian, Y; Wang, Z, 2021) | 2.79 |
Excerpt | Reference | Relevance |
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"Myrtenol treatment notably decreased the status of blood glucose and lipid profile and improved the HDL in the GDM rats." | ( Myrtenol alleviates oxidative stress and inflammation in diabetic pregnant rats via TLR4/MyD88/NF-κB signaling pathway. Chen, G; Liu, M; Qiu, S; Xuemei, L, 2021) | 2.79 |
Pathway | Proteins | Compounds |
---|---|---|
Limonene and Pinene Degradation | 2 | 10 |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID344008 | Antiproliferative activity against human PC3 cells assessed as reduction of cell viability at 400 uM after 72 hrs by WST-1 assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14 | Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. |
AID344010 | Antiproliferative activity against human HL60 cells at 400 uM by WST-1 assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14 | Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. |
AID344009 | Antiproliferative activity against human HL60 cells by WST-1 assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14 | Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. |
AID1066527 | Antiinflammatory activity against human primary chondrocytes assessed as inhibition of IL-1beta-induced NO production at 10 to 25 ug/ml after 30 mins by Griess method | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Anti-inflammatory and chondroprotective activity of (+)-α-pinene: structural and enantiomeric selectivity. |
AID344007 | Antiproliferative activity against human PC3 cells assessed as reduction of cell viability after 72 hrs by WST-1 assay relative to control | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14 | Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (11.76) | 29.6817 |
2010's | 18 (52.94) | 24.3611 |
2020's | 12 (35.29) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (35.50) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 3 (8.57%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 32 (91.43%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |