| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347157 | Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347172 | Secondary qRT-PCR qHTS assay for selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347164 | 384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347171 | Orthogonal mCherry assay for qRT-PCR qHTS of selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347156 | DAPI mCherry counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347163 | 384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347158 | ZIKV-mCherry secondary qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347170 | Vero cells viability counterscreen for qRT-PCR qHTS assay of selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID6709 | In vitro potency against human 5-Lipoxygenase | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids. |
| AID205160 | Tested for inhibition of Ascaris antigen induced bronchoconstriction in the conscious squirrel monkey at 0.3 mg/kg dose (changes in dynamic compliance) | 1994 | Journal of medicinal chemistry, Apr-15, Volume: 37, Issue:8
| Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. |
| AID176948 | Dose-dependent inhibition of LTB4 by the compound after 2 hr of oral pretreatment in rat pleural | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids. |
| AID730632 | Inhibition of 5LOX (unknown origin) using arachidonic acid as substrate after 5 mins by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5
| N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations. |
| AID92720 | Compound was evaluated for production of leukotriene B4 in human whole blood (HWB) activated with ionophore A-23187. | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID205161 | Tested for inhibition of Ascaris antigen induced bronchoconstriction in the conscious squirrel monkey at 0.3 mg/kg dose (changes in the airway resistance() | 1994 | Journal of medicinal chemistry, Apr-15, Volume: 37, Issue:8
| Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. |
| AID432016 | Inhibition of CYP1A2 | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID216286 | In vitro inhibition of LTB4 formation in human whole blood(HWB) | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids. |
| AID204564 | Compound was tested for inhibition of Ascaris -induced bronchoconstriction in sheep at 2.5 ug/kg intravenous administration | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID1230145 | Inhibition of LTB4 production in human whole blood | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
| Recent advances for FLAP inhibitors. |
| AID1067164 | Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate after 5 mins by EIA | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors. |
| AID432014 | Inhibition of CYP2C9 | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID455271 | Inhibition of CYP2C9 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor. |
| AID60544 | Inhibition of ex vivo urinary leukotriene E4 (LTE4) excretion from A-23,187-challenged dog after intravenous infusion of 2.5 ug/kg/min | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID155820 | Effect on production of LTB4 in human polymorphonuclear (HPMN) leukocytes | 1994 | Journal of medicinal chemistry, Apr-15, Volume: 37, Issue:8
| Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. |
| AID92881 | The drug dependent inhibition of LTB4 biosynthesis in human whole blood (HWB) activated with the ionophore A-23187 | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID177877 | Inhibition of LTB4 levels in rat pleural exudates | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID59833 | Ex Vivo generation of LTB4 by whole blood stimulated with calcium ionophore A-23187 in anesthetized dogs | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID160520 | Effect on production of LTB4 in human polymorphonuclear (HPMN) leukocytes | 1994 | Journal of medicinal chemistry, Apr-15, Volume: 37, Issue:8
| Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. |
| AID92731 | Compound was tested for the inhibition of LTB4 production in human whole blood (HWB) | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability. |
| AID7208 | Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]L-691831 as radioligand. | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID177527 | In vivo inhibitory activity against LTB4 biosynthesis by rat pleurisy model (6 pre treatment time periods) | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID314667 | Displacement of [125I]L-691831 from FLAP | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
| Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. |
| AID431372 | Inhibition of CYP2C19 | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID432015 | Inhibition of CYP2D6 | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID12085 | Plasma level at 2 hr after administration of the compound | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID60529 | Inhibition of ex vivo leukotriene B4 (LTB4) in whole blood of A-23,187-challenged dog after intravenous infusion of 2.5 ug/kg/min | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID6731 | Inhibition of Human 5-lipoxygenase | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase. |
| AID125047 | Changes in airway resistance after administration of 0.3 mg/kg in squirrel monkey | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. |
| AID7206 | Inhibition of 5-lipoxygenase activating protein using human leukocyte membrane preparations | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase. |
| AID160521 | In vitro inhibition of LTB4 biosynthesis in Ca++ ionophore activated human polymorphonuclear (HPMN) leukocytes. | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID314670 | Inhibition of calcium ionophore-stimulated LTB4 production in human whole blood | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
| Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. |
| AID432010 | Displacement of [3H]3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzyl-indol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear cell membrane | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID1226813 | Inhibition of soyabean 5-LOX using arachidonic acid as substrate by microplate scanning spectrophotometer analysis | 2015 | European journal of medicinal chemistry, Jun-05, Volume: 97 | Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes. |
| AID1230144 | Binding affinity to FLAP (unknown origin) | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
| Recent advances for FLAP inhibitors. |
| AID12970 | Bioavailability in rat | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID6694 | Inhibition of oxidation of arachidonic acid by human 5-Lipoxygenase using spectrophotometric assay | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID455270 | Inhibition of CYP3A4 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor. |
| AID160511 | Compound was evaluated for production of leukotriene B4 in Ca+2 -ionophore -activated human polymorphonuclear (HPMN) leukocytes. | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID160515 | Test inhibition of LTB4 production in human peripheral blood polymorphonuclear leukocytes (HPMN) | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability. |
| AID177530 | In vivo inhibitory activity against LTB4 biosynthesis by rat pleurisy model (2h pre treatment time period) | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID155822 | In vitro inhibition of LTB4 formation in human peripheral blood polymorphonuclear leukocytes (HPMN) | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids. |
| AID127289 | Changes in dynamic compliance after administration of 0.3 mg/kg in squirrel monkey (not significant) | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. |
| AID432008 | Inhibition of CYP3A4 assessed as inhibition rate | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID6725 | Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenase | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability. |
| AID432011 | Inhibition of calcium ionophore A-23187-stimulated LTB4 production in human leukocytes by ELISA | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID176824 | Tested for antigen-induced dyspnea in hyperreactive rat model (2 hr pretreatment) | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. |
| AID181175 | Compound was evaluated in vivo for its functional activity(in percent) in a hyperreactive rat model of dyspnea | 1999 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 9, Issue:16
| Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. |
| AID432012 | Inhibition of calcium ionophore A-23187-stimulated LTB4 production in human whole blood by ELISA | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID60005 | Inhibition of urinary LTE4 levels in dogs | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID205156 | Compound was tested for inhibition of Ascaris -induced bronchoconstriction in squirrel monkeys | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID177357 | In vivo inhibition of LTB4 biosynthesis in a rat pleurisy model with an 6 hr pretreatment time | 1994 | Journal of medicinal chemistry, Apr-15, Volume: 37, Issue:8
| Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. |
| AID314668 | Inhibition of calcium ionophore-stimulated LTB4 production in human PMN cells | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
| Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. |
| AID432013 | Inhibition of CYP3A4 | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
| AID185614 | compound was tested for inhibition of ovalbumin- induced dyspnea in inbred hyperreactive rats at 0.5 mg/kg | 1997 | Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18
| Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
| Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |