indomethacin has been researched along with Allodynia in 133 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 7.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 7.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| "Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin, have anti-inflammatory activities and are both used in the management of rheumatoid arthritis." | 7.76 | Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. ( Abu-Ghefreh, AA; Masocha, W, 2010) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 7.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| "Neither N/OFQ nor PGE(2) induced allodynia in NOP(-/-) mice." | 5.33 | The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury. ( Civelli, O; Ito, S; Matsumura, S; Minami, T; Okuda-Ashitaka, E; Reinscheid, RK; Takeshima, H, 2006) |
| "Hind-paw hyperalgesia was detected in arthritic rats from the 10th to the 16th day of observation." | 5.29 | Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. ( Carvalho, WM; Ferreira, SH; Francischi, JN; Miranda, AE; Silva, CV; Tatsuo, MA, 1994) |
| "Norepinephrine did enhance spontaneous pain and mechanical and thermal hyperalgesia in capsaicin treated skin." | 5.12 | Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia. ( Baron, R; Binder, A; Hedderich, J; Schattschneider, J; Wasner, G; Zum Buttel, I, 2007) |
| "In the present study, milnacipran showed anti-nociceptive and anti-inflammatory effects on carrageenan-induced hyperalgesia and inflammation in a dose-dependent manner." | 3.96 | Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress. ( Haddadi, R; Rashtiani, R, 2020) |
| "Group containing indomethacin-loaded nanocapsules (NC) presented lower edema in the right hind paw at 24h after formalin injection than those of the control group (CT) (P<0." | 3.85 | Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules. ( Cioato, SG; Collares, FCM; da Silva Torres, IL; de Freitas, JS; Ferreira, MBC; Genari, B; Guterres, SS; Leitune, VCB; Medeiros, LF; Pohlmann, AR; Samuel, SMW, 2017) |
| " The cyclo-oxygenase inhibitor indomethacin partially inhibited knee oedema and allodynia but did not affect the leukocyte influx, myeloperoxidase activity or impaired motion in the kaolin-injected rat." | 3.81 | Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats. ( Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM, 2015) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 3.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 3.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| " As cold allodynia is frequently observed in individuals experiencing toothache pain, we tested whether mice with DPI demonstrate an aversion to drinking cold liquids using a cold-sucrose consumption test." | 3.79 | Paradoxical surrogate markers of dental injury-induced pain in the mouse. ( Basbaum, AI; Gibbs, JL; Urban, R, 2013) |
| "The NO donors nitroglycerin and sodium nitroprusside (SNP) induced allodynia (cold plate test) and hyperalgesia (hot plate test)." | 3.79 | St. John's wort relieves pain in an animal model of migraine. ( Galeotti, N; Ghelardini, C, 2013) |
| " Systemic injection of an NK1 receptor antagonist, WIN 51708, significantly inhibited the joint swelling, but not the mechanical allodynia, on day 7 in CAIA mice." | 3.78 | Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice. ( Ito, H; Makino, A; Sakai, A; Suzuki, H, 2012) |
| "Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia." | 3.78 | Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs. ( Kato, A; Ogawa, K; Shinohara, S; Takasu, K; Yoneda, Y, 2012) |
| " In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner." | 3.78 | Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012) |
| "Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin, have anti-inflammatory activities and are both used in the management of rheumatoid arthritis." | 3.76 | Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. ( Abu-Ghefreh, AA; Masocha, W, 2010) |
| " Following the unilateral intraplantar injection of BmK venom into rat hind paw, it was found: 1) BmK venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von Frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress BmK venom-induced pain responses with different intensity and time courses." | 3.73 | Rat pain-related responses induced by experimental scorpion BmK sting. ( Bai, ZT; Chai, ZF; Ji, YH; Liu, T; Pang, XY, 2006) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 3.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| " This work led to the identification of 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis." | 3.69 | Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). ( Bertenshaw, SR; Burton, EG; Carter, JS; Cogburn, JN; Collins, PW; Docter, S; Graneto, MJ; Gregory, SA; Isakson, PC; Koboldt, CM; Lee, LF; Malecha, JW; Miyashiro, JM; Penning, TD; Perkins, WE; Rogers, RS; Rogier, DJ; Seibert, K; Talley, JJ; Veenhuizen, AW; Yu, SS; Zhang, YY, 1997) |
| "Indomethacin, a typical cyclo-oxygenase inhibitor, acts as an analgesic by preventing the hyperalgesia induced by prostaglandins during inflammation." | 3.69 | Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. ( Ferreira, SH; Tonussi, CR, 1994) |
| "Oxaceprol, an established therapeutic agent for osteoarthritis, had no effect on macrophage prostaglandin E2 release in vitro and inhibited carrageenan paw oedema at high doses (18-150 mg/kg p." | 3.69 | Oxaceprol, an atypical inhibitor of inflammation and joint damage. ( Brune, K; Ionac, M; Parnham, MJ; Plauchithiu, M, 1996) |
| "Dipyrone blocked carrageenin-induced oedema and hyperalgesia in a dose-dependent manner." | 3.67 | Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia. ( Ferreira, SH; Lorenzetti, BB, 1985) |
| "5 per cent indomethacin (IM) solution to the sunburned skin of humans and guinea pigs resulted in a marked decrease in ultraviolet light (UVL) -induced erythema." | 3.65 | Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on UV-damaged skin. ( Snyder, DS, 1975) |
| " The mechanism underpinning pain relief induced by the GlyT2 inhibitor at 10 mg/kg is likely due to increased glycinergic inhibition in the lumbar spinal cord, although the bell-shaped dose-response curve warrants further translational considerations." | 1.62 | Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy. ( Corradini, L; Kuo, A; Nicholson, JR; Smith, MT, 2021) |
| "The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "In addition, PLSN-induced mechanical and thermal hyperalgesia was prevented by systemic (i." | 1.40 | The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice. ( Calixto, JB; Costa, R; Manjavachi, MN; Quintão, NL, 2014) |
| "Pain is the most common reason a patient sees a physician." | 1.40 | Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| "The same procedure suppressed allodynia and hyperalgesia in the cancer model, but the suppression was weak when compared with that in the inflammation model." | 1.36 | Differences between orofacial inflammation and cancer pain. ( Harano, N; Hidaka, K; Inenaga, K; Kai, A; Nakanishi, O; Ono, K, 2010) |
| "Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2)." | 1.36 | Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats. ( Bakhle, YS; Camêlo, VM; de Francischi, JN; Dos Reis, WG; Paiva-Lima, P; Rezende, RM, 2010) |
| " For these studies, animals were dosed with CP-154,526 (3, 10, 30 mg/kg) and NBI 27914 (1-30 mg/kg) 1 h prior to the assessment of tactile, thermal or mechanical hypersensitivity, respectively." | 1.36 | Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. ( Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT, 2010) |
| "The development of hyperalgesia was dose dependently prevented by the NSAID indomethacin (ED50=2." | 1.35 | Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw. ( Chen, JJ; Ding, X; Dong, H; Johnson, EJ; Kumar, GN; Magal, E; Manning, BH; Sun, H, 2008) |
| "Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "Hyperalgesia was detected 2 h after nerve transection and persisted for 64 days." | 1.35 | The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators. ( Amorim, RL; Brigatte, P; Conceição, IM; Cury, Y; Della-Casa, MS; Ferreira, WA; Gutierrez, VP; Nicoletti, JL; Nogueira-Neto, Fde S; Picolo, G; Takahira, RK, 2008) |
| "Its role as a mediator of hyperalgesia (clinically defined as an augmented sensitivity to painful stimuli) is not known." | 1.35 | Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. ( Cuzzocrea, S; Di Paola, R; Esposito, E; Matuschak, GM; Mazzon, E; Ndengele, MM; Salvemini, D, 2008) |
| " Recently, we described a novel series of potent, selective, and orally bioavailable delta opioid receptor agonists." | 1.35 | Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). ( Ajello, CW; Barker, WM; Belanger, S; Brogdon, BL; Cassel, JA; Chu, GH; DeHaven, RN; DeHaven-Hudkins, DL; Derelanko, MJ; Dolle, RE; Feschenko, MS; Graczyk, TM; Gu, M; Koblish, M; Kutz, S; Le Bourdonnec, B; Leister, LK; Little, PJ; Smith, SA; Tuthill, PA; Wiant, DD; Windh, RT; Zhou, QJ, 2009) |
| "Bradykinin-induced hyperalgesia was abolished by co-administration with the B(2) receptor antagonist Hoe 140 (5 pmol/site), the NMDA antagonist MK-801 (5 nmol/site), the cyclooxygenase inhibitor indomethacin (10 nmol/site) and the glial metabolic inhibitor fluorocitrate (1 nmol/site)." | 1.34 | Bradykinin into amygdala induces thermal hyperalgesia in rats. ( Bellé, NA; Calixto, JB; Dalmolin, GD; Ferreira, J; Mello, CF; Rubin, MA; Silva, CR, 2007) |
| "CION caused ipsilateral cold hyperalgesia between Days 2 and 12, which peaked on Days 4 (sham 15." | 1.33 | Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. ( Chichorro, JG; Rae, GA; Souza, GE; Zampronio, AR, 2006) |
| "Mechanical hyperalgesia induced in rat paws by carrageenan (250microg) was modified by pre-treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib and SC236." | 1.33 | Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan. ( Bakhle, YS; Duarte, ID; Ferreira-Alves, DL; França, DS; Francischi, JN; Rezende, RM; Ribeiro, MC, 2006) |
| "Pretreatment with indomethacin (4 mg/kg, i." | 1.33 | A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics. ( Cordeiro, RS; Lavich, TR; Martins, MA; Silva, PM, 2005) |
| "NDGA significantly inhibited edema, hyperalgesia, and arthritis score in TRPV1+/+, but not in TRPV1-/- mice." | 1.33 | Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice. ( Bánvölgyi, A; Bite, A; Bölcskei, K; Elekes, K; Helyes, Z; Németh, J; Pintér, E; Sándor, K; Szabó, A; Szolcsányi, J, 2005) |
| "Pain and cachexia are two of the most debilitating aspects of rheumatoid arthritis." | 1.33 | Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis. ( Ho, WH; Pons, J; Rosenthal, A; Shelton, DL; Zeller, J, 2005) |
| "Nitroglycerin-induced hyperalgesia can be detected as an increase in the nociceptive behavior evoked by the formalin test." | 1.33 | Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D, 2006) |
| "Neither N/OFQ nor PGE(2) induced allodynia in NOP(-/-) mice." | 1.33 | The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury. ( Civelli, O; Ito, S; Matsumura, S; Minami, T; Okuda-Ashitaka, E; Reinscheid, RK; Takeshima, H, 2006) |
| "3." | 1.32 | Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004) |
| "This blockade of PGE2 mechanical hyperalgesia induced by diclofenac (100 microg/paw) was antagonized in a dose-dependent manner by intraplantar administration of the sulphonylureas glibenclamide (40, 80 and 160 microg) and tolbutamide (80, 160 and 320 microg), specific blockers of ATP-sensitive K+ channels, and it was observed even when the hyperalgesic agent used was carrageenin, while the antinociceptive action of indomethacin (200 microg/paw), a typical cyclo-oxygenase inhibitor, over carrageenin-induced hyperalgesia was not affected by this treatment." | 1.32 | Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation. ( Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA, 2004) |
| " Both low- and high-frequency EA combined with INDO enhanced antihyperalgesia compared to each component alone, and 10 Hz but not 100 Hz EA significantly reduced CFA-induced hind paw edema." | 1.32 | Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats. ( Berman, BB; Lao, L; Ren, K; Wang, X; Zhang, RX, 2004) |
| "Pretreatment with PAT prevented the hyperalgesia and maintained the body temperature within the normal range and was accompanied by a down-regulation of the levels of pro-inflammatory cytokines and PGE(2) in the liver." | 1.31 | Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat. ( Dardenne, M; Pléau, JM; Saadé, NE; Safieh-Garabedian, B, 2002) |
| "2." | 1.31 | Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation. ( Bakhle, YS; Chaves, CT; Ferreira-Alves, DL; Francischi, JN; Lima, AS; Moura, AC; Rocha, OA, 2002) |
| "Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i." | 1.31 | Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum. ( Domont, GB; Frutuoso, VS; Martins, MA; Moussatché, H; Perales, J; Rocha, SL, 2000) |
| "In conclusion, NO and PGE2 affect the hyperalgesia induced by excitatory amino acids." | 1.31 | The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats. ( Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD, 2000) |
| "iNOS-/- mice exhibited reduced thermal hyperalgesia after zymosan injection." | 1.31 | Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. ( Ates, M; Brune, K; Coste, O; Görig, M; Gühring, H; Pahl, A; Rehse, K; Zeilhofer, HU, 2000) |
| "In these studies, carrageenan-induced thermal hyperalgesia was evaluated in the mouse and the role of NGF and the MAPK pathway investigated." | 1.31 | Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway. ( Bingham, S; Davey, PT; Parsons, AA; Raval, P; Rogers, D; Sammons, MJ, 2000) |
| "Bothrops asper venom-induced hyperalgesia was blocked by the bradykinin B(2) receptor antagonist HOE 140 and attenuated by dexamethasone, an inhibitor of phospholipase A(2)." | 1.31 | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom. ( Chacur, M; Cury, Y; Gutiérrez, JM; Picolo, G; Teixeira, CF, 2001) |
| "Indomethacin treatment reversed all the measured parameters, although the reversal of mechanical allodynia was only partial." | 1.31 | Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis. ( Fuseler, J; Grisham, M; Roerig, SC; Tedesco, LS; Wolf, R, 2002) |
| "In a second model, hyperalgesia was induced by the i." | 1.31 | Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2002) |
| "Indomethacin was a potent inhibitor of both COX-1 (IC50 = 18 +/- 3 nM) and COX-2 (IC50 = 26 +/- 6 nM) under the same assay conditions." | 1.30 | Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. ( Boyce, S; Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, J; Falgueyret, JP; Ford-Hutchinson, AW; Gordon, R; Greig, G; Gresser, M; Guay, J; Kargman, S; Léger, S; Mancini, JA; O'Neill, G; Ouellet, M; Percival, MD; Riendeau, D; Rodger, IW; Thérien, M; Wang, Z; Webb, JK; Wong, E, 1997) |
| "A new model of endotoxin (ET)-induced hyperalgesia has been used to test the effects of four classes of drugs in rats and mice." | 1.30 | Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. ( Abdelnoor, AM; Atweh, SF; Haddad, JJ; Jabbur, SJ; Kanaan, SA; Saadé, NE; Safieh-Garabedian, B, 1997) |
| " They were found fairly potent in rat tail flick and mouse phenylquinone writhing assays but the dose-response curves were rather shallow as compared to that of morphine." | 1.30 | Apparent antinociceptive and anti-inflammatory effects of GYKI 52466. ( Kedves, R; Máté, I; Székely, JI; Tarnawa, I; Török, K, 1997) |
| "In rats with yeast-induced hyperalgesia, JTE-522 showed a dose-dependent antinociceptive effect (ED50: 4." | 1.30 | Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats. ( Masaki, M; Matsushita, M; Tanaka, T; Wakitani, K; Yagi, Y, 1997) |
| "The thermal hyperalgesia was evident 20 min after injection and lasted less than 4 h." | 1.30 | Effect of colchicine on nerve growth factor-induced leukocyte accumulation and thermal hyperalgesia in the rat. ( Schuligoi, R, 1998) |
| "Mechanical hyperalgesia produced by prostaglandin E2, a direct-acting hyperalgesic agent, was not significantly affected by vagotomy." | 1.30 | Modulation of bradykinin-induced mechanical hyperalgesia in the rat by activity in abdominal vagal afferents. ( Jänig, W; Khasar, SG; Levine, JD; Miao, JP, 1998) |
| "The BjV-induced hyperalgesia was markedly attenuated by dexamethasone." | 1.29 | Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF). ( Cury, Y; Jancar, S; Oga, S; Teixeira, CF, 1994) |
| "Bradykinin-induced hyperalgesia was abolished by HOE 140 and by treatment of the paws with anti-TNF-alpha antisera." | 1.29 | Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia. ( Cunha, FQ; Ferreira, SH; Lorenzetti, BB; Poole, S, 1993) |
| "In another group, the hyperalgesia was removed almost completely for at least 24 hours by one dose of laser irradiation, which was given 3 hours after the carrageenin injection, whereas the edema was not inhibited." | 1.29 | Analgesic effect of Ga-Al-As diode laser irradiation on hyperalgesia in carrageenin-induced inflammation. ( Haruki, E; Honmura, A; Ishii, A; Obata, J; Yanase, M, 1993) |
| "LPS induced thermal and mechanical hyperalgesia which was reversed by i." | 1.29 | Development of hyperthermia and hyperalgesia following intracerebroventricular administration of endotoxin in the rat: effect of kinin B1 and B2 receptor antagonists. ( Dray, A; Perkins, M; Walker, K, 1996) |
| "1." | 1.29 | Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. ( Allchorne, A; Poole, S; Safieh-Garabedian, B; Winter, J; Woolf, CJ, 1995) |
| "Pain was induced by intraplantar injection of carrageenan (3 mg) into the hind paw of rats." | 1.29 | Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats. ( Pichler, L; Schramm, W; Schwarz, HP; Ulrich, W; Varadi, K, 1995) |
| "Hind-paw hyperalgesia was detected in arthritic rats from the 10th to the 16th day of observation." | 1.29 | Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. ( Carvalho, WM; Ferreira, SH; Francischi, JN; Miranda, AE; Silva, CV; Tatsuo, MA, 1994) |
| "We conclude that serotonin produces hyperalgesia by a direct action on the primary afferent neuron via the 5-HT1A subset of serotonin receptors." | 1.28 | Serotonin is a directly-acting hyperalgesic agent in the rat. ( Levine, JD; Taiwo, YO, 1992) |
| "Hyperalgesia was assessed by a decrease in response latency to a 3." | 1.28 | New analgesic assay utilizing trypsin-induced hyperalgesia in the hind limb of the rat. ( Johnston, PR; Selph, JL; Truax, JF; Vinegar, R, 1990) |
| "This hyperalgesia can be inhibited by prior administration of either indomethacin or delta 1-THC-7-oic acid, presumably because of their ability to inhibit eicosanoid synthesis." | 1.27 | Cannabinoids and pain responses: a possible role for prostaglandins. ( Burstein, SH; Hull, K; Hunter, SA; Latham, V, 1988) |
| "Preliminary characterization of the hyperalgesia-inducing activity released by stimulated PMNLs indicated that it is lipid in nature." | 1.27 | The role of the polymorphonuclear leukocyte in hyperalgesia. ( Borden, L; Donatoni, P; Goetzl, EJ; Gooding, J; Levine, JD, 1985) |
| "Bilateral hyperalgesia was observed when this factor, denoted macrophage hyperalgesic factor (MHF), was injected into one hind paw or into the peritoneal cavity of the rat." | 1.27 | Interleukin-1 mimics the hyperalgesia induced by a factor obtained by macrophage lysis. ( Ferreira, SH; Francischi, JN; Lorenzetti, BB, 1988) |
| "A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described." | 1.27 | A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. ( Brown, F; Dubner, R; Flores, C; Hargreaves, K; Joris, J, 1988) |
| "4." | 1.26 | Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors. ( Ferreira, SH; Vargaftig, BB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (7.52) | 18.7374 |
| 1990's | 38 (28.57) | 18.2507 |
| 2000's | 48 (36.09) | 29.6817 |
| 2010's | 33 (24.81) | 24.3611 |
| 2020's | 4 (3.01) | 2.80 |
| Authors | Studies |
|---|---|
| Penning, TD | 1 |
| Talley, JJ | 2 |
| Bertenshaw, SR | 1 |
| Carter, JS | 1 |
| Collins, PW | 2 |
| Docter, S | 1 |
| Graneto, MJ | 1 |
| Lee, LF | 1 |
| Malecha, JW | 1 |
| Miyashiro, JM | 1 |
| Rogers, RS | 1 |
| Rogier, DJ | 1 |
| Yu, SS | 1 |
| Burton, EG | 1 |
| Cogburn, JN | 2 |
| Gregory, SA | 2 |
| Koboldt, CM | 3 |
| Perkins, WE | 2 |
| Seibert, K | 4 |
| Veenhuizen, AW | 2 |
| Zhang, YY | 2 |
| Isakson, PC | 4 |
| Song, Y | 2 |
| Connor, DT | 2 |
| Doubleday, R | 2 |
| Sorenson, RJ | 2 |
| Sercel, AD | 2 |
| Unangst, PC | 2 |
| Roth, BD | 2 |
| Gilbertsen, RB | 2 |
| Chan, K | 2 |
| Schrier, DJ | 2 |
| Guglietta, A | 2 |
| Bornemeier, DA | 2 |
| Dyer, RD | 2 |
| Beylin, VG | 1 |
| Khanna, IK | 1 |
| Yu, Y | 1 |
| Huff, RM | 1 |
| Weier, RM | 1 |
| Xu, X | 1 |
| Koszyk, FJ | 1 |
| Masferrer, JL | 3 |
| Yuan, J | 1 |
| Yang, DC | 1 |
| Szabó, G | 1 |
| Fischer, J | 1 |
| Kis-Varga, A | 1 |
| Gyires, K | 1 |
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Le Bourdonnec, B | 1 |
| Windh, RT | 1 |
| Leister, LK | 1 |
| Zhou, QJ | 1 |
| Ajello, CW | 1 |
| Gu, M | 1 |
| Chu, GH | 1 |
| Tuthill, PA | 1 |
| Barker, WM | 1 |
| Koblish, M | 1 |
| Wiant, DD | 1 |
| Graczyk, TM | 1 |
| Belanger, S | 1 |
| Cassel, JA | 1 |
| Feschenko, MS | 1 |
| Brogdon, BL | 1 |
| Smith, SA | 1 |
| Derelanko, MJ | 1 |
| Kutz, S | 1 |
| Little, PJ | 1 |
| DeHaven, RN | 1 |
| DeHaven-Hudkins, DL | 1 |
| Dolle, RE | 1 |
| Uramaru, N | 1 |
| Shigematsu, H | 1 |
| Toda, A | 1 |
| Eyanagi, R | 1 |
| Kitamura, S | 1 |
| Ohta, S | 1 |
| Borghi, SM | 1 |
| Carvalho, TT | 2 |
| Staurengo-Ferrari, L | 2 |
| Hohmann, MS | 2 |
| Pinge-Filho, P | 1 |
| Casagrande, R | 4 |
| Verri, WA | 6 |
| Yogeeswari, P | 1 |
| Sharma, M | 1 |
| Samala, G | 1 |
| Gangadhar, M | 1 |
| Karthick, S | 1 |
| Mallipeddi, S | 1 |
| Semwal, A | 1 |
| Sriram, D | 1 |
| Possebon, MI | 1 |
| Mizokami, SS | 2 |
| Zarpelon, AC | 3 |
| Ferraz, CR | 1 |
| Hayashida, TH | 1 |
| de Souza, AR | 1 |
| Ambrosio, SR | 1 |
| Arakawa, NS | 1 |
| Lima, Mda S | 1 |
| Evangelista, AF | 1 |
| Santos, GG | 1 |
| Ribeiro, IM | 1 |
| Tomassini, TC | 1 |
| Pereira Soares, MB | 1 |
| Villarreal, CF | 2 |
| Singh, P | 3 |
| Prasher, P | 1 |
| Dhillon, P | 1 |
| Bhatti, R | 3 |
| Kaur, S | 2 |
| Kumari, P | 2 |
| Kaur, B | 1 |
| Kaur, M | 1 |
| Singh, G | 1 |
| Bhatti, M | 1 |
| Kaur, J | 1 |
| Haddadi, R | 1 |
| Rashtiani, R | 1 |
| Kuo, A | 1 |
| Corradini, L | 1 |
| Nicholson, JR | 1 |
| Smith, MT | 1 |
| Lima, LM | 1 |
| da Silva, TF | 1 |
| da Silva Monteiro, CE | 1 |
| Aparecida-Silva, C | 1 |
| Bispo Júnior, W | 1 |
| de Queiroz, AC | 1 |
| Alexandre-Moreira, MS | 1 |
| Zapata-Sudo, G | 1 |
| Barreiro, EJ | 1 |
| Genari, B | 1 |
| Ferreira, MBC | 1 |
| Medeiros, LF | 1 |
| de Freitas, JS | 1 |
| Cioato, SG | 1 |
| da Silva Torres, IL | 1 |
| Pohlmann, AR | 1 |
| Guterres, SS | 1 |
| Leitune, VCB | 1 |
| Collares, FCM | 1 |
| Samuel, SMW | 1 |
| Tsubota, M | 1 |
| Ozaki, T | 1 |
| Hayashi, Y | 1 |
| Okawa, Y | 1 |
| Fujimura, A | 1 |
| Sekiguchi, F | 1 |
| Nishikawa, H | 1 |
| Kawabata, A | 1 |
| Buonvicino, D | 1 |
| Urru, M | 1 |
| Muzzi, M | 1 |
| Ranieri, G | 1 |
| Luceri, C | 1 |
| Oteri, C | 1 |
| Lapucci, A | 1 |
| Chiarugi, A | 1 |
| Gibbs, JL | 1 |
| Urban, R | 1 |
| Basbaum, AI | 1 |
| Calixto-Campos, C | 1 |
| Corrêa, M | 1 |
| Cardoso, RD | 1 |
| Pinho-Ribeiro, FA | 2 |
| Cecchini, R | 1 |
| Moreira, EG | 1 |
| Crespigio, J | 1 |
| Bernardy, CC | 1 |
| Manjavachi, MN | 1 |
| Costa, R | 1 |
| Quintão, NL | 2 |
| Calixto, JB | 2 |
| Parvathy, SS | 1 |
| Masocha, W | 2 |
| Camargo, LL | 1 |
| Denadai-Souza, A | 1 |
| Yshii, LM | 1 |
| Mesquita, FP | 1 |
| Soares, AG | 1 |
| Lima, C | 1 |
| Schenka, A | 1 |
| Grant, A | 1 |
| Fernandes, E | 1 |
| Muscará, MN | 1 |
| Costa, SK | 1 |
| Bellei, E | 1 |
| Monari, E | 1 |
| Bergamini, S | 1 |
| Cuoghi, A | 1 |
| Tomasi, A | 1 |
| Guerzoni, S | 1 |
| Ciccarese, M | 1 |
| Pini, LA | 1 |
| Fattori, V | 1 |
| Manchope, MF | 1 |
| Matsuura, W | 1 |
| Harada, S | 1 |
| Tokuyama, S | 1 |
| Guzmán-Priego, CG | 1 |
| Méndez-Mena, R | 1 |
| Baños-González, MA | 1 |
| Araiza-Saldaña, CI | 1 |
| Castañeda-Corral, G | 1 |
| Torres-López, JE | 1 |
| Nogueira-Neto, Fde S | 1 |
| Amorim, RL | 1 |
| Brigatte, P | 1 |
| Picolo, G | 2 |
| Ferreira, WA | 1 |
| Gutierrez, VP | 1 |
| Conceição, IM | 1 |
| Della-Casa, MS | 1 |
| Takahira, RK | 1 |
| Nicoletti, JL | 1 |
| Cury, Y | 3 |
| Bujalska, M | 1 |
| Pelegrini-da-Silva, A | 1 |
| Oliveira, MC | 1 |
| Parada, CA | 4 |
| Tambeli, CH | 2 |
| Bastos, LC | 1 |
| Tonussi, CR | 3 |
| Piesla, MJ | 1 |
| Leventhal, L | 1 |
| Strassle, BW | 1 |
| Harrison, JE | 2 |
| Cummons, TA | 1 |
| Lu, P | 2 |
| Whiteside, GT | 3 |
| da Silva, GF | 1 |
| Antonialli, CS | 1 |
| Rocha, LW | 1 |
| Cechinel Filho, V | 1 |
| Cicció, JF | 1 |
| Harano, N | 1 |
| Ono, K | 1 |
| Hidaka, K | 1 |
| Kai, A | 1 |
| Nakanishi, O | 1 |
| Inenaga, K | 1 |
| Hummel, M | 1 |
| Cummons, T | 1 |
| Mark, L | 2 |
| Kennedy, JD | 1 |
| Rezende, RM | 2 |
| Paiva-Lima, P | 1 |
| Dos Reis, WG | 2 |
| Camêlo, VM | 1 |
| Bakhle, YS | 3 |
| de Francischi, JN | 1 |
| Abu-Ghefreh, AA | 1 |
| Mohy El-Din, MM | 1 |
| Senbel, AM | 1 |
| Bistawroos, AA | 1 |
| El-Mallah, A | 1 |
| Nour El-Din, NA | 1 |
| Bekhit, AA | 1 |
| Abd El Razik, HA | 1 |
| Uematsu, T | 1 |
| Sakai, A | 2 |
| Ito, H | 2 |
| Suzuki, H | 2 |
| Ogawa, K | 1 |
| Takasu, K | 1 |
| Shinohara, S | 1 |
| Yoneda, Y | 1 |
| Kato, A | 1 |
| Sasso, O | 1 |
| Bertorelli, R | 1 |
| Bandiera, T | 1 |
| Scarpelli, R | 1 |
| Colombano, G | 1 |
| Armirotti, A | 1 |
| Moreno-Sanz, G | 1 |
| Reggiani, A | 1 |
| Piomelli, D | 1 |
| Makino, A | 1 |
| Galeotti, N | 2 |
| Ghelardini, C | 2 |
| Funez, MI | 1 |
| Cunha, Fde Q | 1 |
| Ferreira, SH | 18 |
| Araldi, D | 1 |
| Ferrari, LF | 1 |
| Lotufo, CM | 1 |
| Vieira, AS | 1 |
| Athié, MC | 1 |
| Figueiredo, JG | 1 |
| Duarte, DB | 1 |
| Safieh-Garabedian, B | 4 |
| Dardenne, M | 1 |
| Pléau, JM | 1 |
| Saadé, NE | 3 |
| Pintér, E | 2 |
| Helyes, Z | 2 |
| Németh, J | 2 |
| Pórszász, R | 1 |
| Pethö, G | 1 |
| Thán, M | 1 |
| Kéri, G | 1 |
| Horváth, A | 1 |
| Jakab, B | 1 |
| Szolcsányi, J | 2 |
| Grazioli, I | 1 |
| Uslenghi, C | 1 |
| Liu, J | 1 |
| Zhang, QJ | 1 |
| Guo, BC | 1 |
| Cao, DY | 1 |
| Wang, KM | 1 |
| Francischi, JN | 5 |
| Chaves, CT | 1 |
| Moura, AC | 1 |
| Lima, AS | 1 |
| Rocha, OA | 1 |
| Ferreira-Alves, DL | 3 |
| Pereira, LS | 1 |
| de Resende, MA | 1 |
| Romualdo, VA | 1 |
| Lopes, MT | 1 |
| Santoro, MM | 1 |
| Harrison, J | 1 |
| Boulet, J | 1 |
| Pearson, M | 1 |
| Gottshall, S | 1 |
| Walker, K | 2 |
| Alves, DP | 1 |
| Tatsuo, MA | 2 |
| Leite, R | 1 |
| Duarte, ID | 2 |
| Waldron, JB | 1 |
| Sawynok, J | 1 |
| Zhang, RX | 1 |
| Lao, L | 1 |
| Wang, X | 1 |
| Ren, K | 1 |
| Berman, BB | 1 |
| Lavich, TR | 1 |
| Cordeiro, RS | 1 |
| Silva, PM | 1 |
| Martins, MA | 2 |
| Szabó, A | 1 |
| Sándor, K | 1 |
| Bite, A | 1 |
| Bánvölgyi, A | 1 |
| Bölcskei, K | 1 |
| Elekes, K | 1 |
| Shelton, DL | 1 |
| Zeller, J | 1 |
| Ho, WH | 1 |
| Pons, J | 1 |
| Rosenthal, A | 1 |
| Fulgenzi, A | 1 |
| Dell'Antonio, G | 1 |
| Foglieni, C | 1 |
| Dal Cin, E | 1 |
| Ticozzi, P | 1 |
| Franzone, JS | 1 |
| Ferrero, ME | 1 |
| Singh, VP | 1 |
| Patil, CS | 1 |
| Kulkarni, SK | 1 |
| Tassorelli, C | 1 |
| Greco, R | 1 |
| Wang, D | 1 |
| Sandrini, G | 1 |
| Nappi, G | 1 |
| Okuda-Ashitaka, E | 1 |
| Minami, T | 1 |
| Matsumura, S | 1 |
| Takeshima, H | 1 |
| Reinscheid, RK | 1 |
| Civelli, O | 1 |
| Ito, S | 1 |
| Chichorro, JG | 1 |
| Zampronio, AR | 1 |
| Souza, GE | 1 |
| Rae, GA | 1 |
| França, DS | 1 |
| Ribeiro, MC | 1 |
| Bai, ZT | 1 |
| Liu, T | 1 |
| Chai, ZF | 1 |
| Pang, XY | 1 |
| Ji, YH | 1 |
| Schattschneider, J | 1 |
| Zum Buttel, I | 1 |
| Binder, A | 1 |
| Wasner, G | 1 |
| Hedderich, J | 1 |
| Baron, R | 1 |
| Ramos, KM | 1 |
| Jiang, Y | 1 |
| Svensson, CI | 2 |
| Calcutt, NA | 2 |
| Sam, TS | 1 |
| Ngan, MP | 1 |
| Riendeau, D | 2 |
| Robichaud, A | 1 |
| Rudd, JA | 1 |
| Dalmolin, GD | 1 |
| Silva, CR | 1 |
| Bellé, NA | 1 |
| Rubin, MA | 1 |
| Mello, CF | 1 |
| Ferreira, J | 1 |
| Cunha, TM | 2 |
| Fukada, SY | 1 |
| Guerrero, AT | 2 |
| Santodomingo-Garzón, T | 1 |
| Poole, S | 7 |
| Cunha, FQ | 6 |
| Ortiz, MI | 1 |
| Ponce-Monter, H | 1 |
| Fernández-Martínez, E | 1 |
| Pérez-Hernández, N | 1 |
| Macías, A | 1 |
| Rangel-Flores, E | 1 |
| Castañeda-Hernández, G | 1 |
| Dong, H | 1 |
| Sun, H | 1 |
| Magal, E | 1 |
| Ding, X | 1 |
| Kumar, GN | 1 |
| Chen, JJ | 1 |
| Johnson, EJ | 1 |
| Manning, BH | 1 |
| Morgan, JR | 1 |
| Gebhart, GF | 1 |
| Barsante, MM | 1 |
| Coelho, FM | 1 |
| Bertini, R | 1 |
| Di Giacinto, C | 1 |
| Allegretti, M | 1 |
| Teixeira, MM | 1 |
| Ndengele, MM | 1 |
| Cuzzocrea, S | 1 |
| Esposito, E | 1 |
| Mazzon, E | 1 |
| Di Paola, R | 1 |
| Matuschak, GM | 1 |
| Salvemini, D | 1 |
| Winter, CA | 1 |
| Kling, PJ | 1 |
| Vargaftig, BB | 1 |
| Bustos, G | 1 |
| Ferrándiz, ML | 1 |
| Sanz, MJ | 1 |
| Payá, M | 1 |
| Alcaraz, MJ | 1 |
| Allchorne, A | 1 |
| Winter, J | 1 |
| Woolf, CJ | 1 |
| Pichler, L | 1 |
| Schramm, W | 1 |
| Ulrich, W | 1 |
| Varadi, K | 1 |
| Schwarz, HP | 1 |
| Davis, AJ | 1 |
| Perkins, MN | 1 |
| Lorenzetti, BB | 8 |
| Devissaguet, M | 1 |
| Lesieur, D | 1 |
| Tsouderos, Y | 1 |
| Carvalho, WM | 1 |
| Silva, CV | 1 |
| Miranda, AE | 1 |
| Teixeira, CF | 2 |
| Oga, S | 1 |
| Jancar, S | 1 |
| Honmura, A | 1 |
| Ishii, A | 1 |
| Yanase, M | 1 |
| Obata, J | 1 |
| Haruki, E | 1 |
| Ahlgren, SC | 1 |
| Levine, JD | 4 |
| Dray, A | 1 |
| Perkins, M | 1 |
| Ionac, M | 1 |
| Parnham, MJ | 1 |
| Plauchithiu, M | 1 |
| Brune, K | 2 |
| Portanova, JP | 1 |
| Zhang, Y | 2 |
| Anderson, GD | 1 |
| Hauser, SD | 1 |
| Percival, MD | 1 |
| Boyce, S | 1 |
| Brideau, C | 1 |
| Charleson, S | 1 |
| Cromlish, W | 1 |
| Ethier, D | 1 |
| Evans, J | 1 |
| Falgueyret, JP | 1 |
| Ford-Hutchinson, AW | 1 |
| Gordon, R | 1 |
| Greig, G | 1 |
| Gresser, M | 1 |
| Guay, J | 1 |
| Kargman, S | 1 |
| Léger, S | 1 |
| Mancini, JA | 1 |
| O'Neill, G | 1 |
| Ouellet, M | 1 |
| Rodger, IW | 1 |
| Thérien, M | 1 |
| Wang, Z | 1 |
| Webb, JK | 1 |
| Wong, E | 1 |
| Chan, CC | 1 |
| Hay, CH | 1 |
| Trevethick, MA | 1 |
| Wheeldon, A | 1 |
| Bowers, JS | 1 |
| de Belleroche, JS | 1 |
| Kanaan, SA | 2 |
| Haddad, JJ | 1 |
| Atweh, SF | 1 |
| Abdelnoor, AM | 1 |
| Jabbur, SJ | 2 |
| Székely, JI | 1 |
| Kedves, R | 1 |
| Máté, I | 1 |
| Török, K | 1 |
| Tarnawa, I | 1 |
| Jalakhian, RH | 1 |
| Matsushita, M | 1 |
| Masaki, M | 1 |
| Yagi, Y | 1 |
| Tanaka, T | 1 |
| Wakitani, K | 1 |
| Aloe, L | 1 |
| Moroni, R | 1 |
| Angelucci, F | 1 |
| Fiore, M | 1 |
| Kido, H | 1 |
| Murakami, N | 1 |
| Ito, A | 1 |
| Kimura, K | 1 |
| Kodera, N | 1 |
| Doi, T | 1 |
| Naruse, T | 1 |
| Lopez-Garcia, JA | 1 |
| Laird, JM | 1 |
| Khasar, SG | 1 |
| Miao, JP | 1 |
| Jänig, W | 1 |
| Schuligoi, R | 1 |
| Smith, CJ | 1 |
| Muhammad, J | 1 |
| Zweifel, BS | 1 |
| Shaffer, A | 1 |
| Yamamoto, T | 1 |
| Sakashita, Y | 1 |
| Yasuda, T | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Cunha, JM | 1 |
| Syriatowicz, JP | 1 |
| Hu, D | 1 |
| Walker, JS | 1 |
| Tracey, DJ | 1 |
| Ochi, T | 1 |
| Fujii, T | 1 |
| Motoyama, Y | 1 |
| Goto, T | 1 |
| Rocha, SL | 1 |
| Frutuoso, VS | 1 |
| Domont, GB | 1 |
| Moussatché, H | 1 |
| Perales, J | 1 |
| Park, YH | 1 |
| Shin, CY | 1 |
| Lee, TS | 1 |
| Huh, IH | 1 |
| Sohn, UD | 1 |
| Almeida, FR | 1 |
| Schivo, IR | 1 |
| Gühring, H | 1 |
| Görig, M | 1 |
| Ates, M | 1 |
| Coste, O | 1 |
| Zeilhofer, HU | 1 |
| Pahl, A | 1 |
| Rehse, K | 1 |
| Sammons, MJ | 1 |
| Raval, P | 1 |
| Davey, PT | 1 |
| Rogers, D | 1 |
| Parsons, AA | 1 |
| Bingham, S | 1 |
| Chacur, M | 1 |
| Gutiérrez, JM | 1 |
| Conti, S | 1 |
| Costa, B | 1 |
| Colleoni, M | 1 |
| Parolaro, D | 1 |
| Giagnoni, G | 1 |
| Tedesco, LS | 1 |
| Fuseler, J | 1 |
| Grisham, M | 1 |
| Wolf, R | 1 |
| Roerig, SC | 1 |
| Sachs, D | 1 |
| Freshwater, JD | 1 |
| Malmberg, AB | 1 |
| Snyder, DS | 1 |
| Taiwo, YO | 1 |
| Vinegar, R | 1 |
| Truax, JF | 1 |
| Selph, JL | 1 |
| Johnston, PR | 1 |
| Burstein, SH | 1 |
| Hull, K | 1 |
| Hunter, SA | 1 |
| Latham, V | 1 |
| Gooding, J | 1 |
| Donatoni, P | 1 |
| Borden, L | 1 |
| Goetzl, EJ | 1 |
| de Campos, DI | 1 |
| Bristow, AF | 1 |
| Hargreaves, K | 1 |
| Dubner, R | 1 |
| Brown, F | 1 |
| Flores, C | 1 |
| Joris, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| In Vivo Selectivity of Cyclooxygenase Inhibitors in the Oral Surgery Model[NCT00006299] | Phase 2 | 120 participants | Interventional | 1999-12-31 | Completed | ||
| Cytokine Responses to Acute Inflammation in the Oral Surgery Model[NCT00006175] | 160 participants | Observational | 2000-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for indomethacin and Allodynia
| Article | Year |
|---|---|
Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, | 2007 |
132 other studies available for indomethacin and Allodynia
| Article | Year |
|---|---|
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Carrageenan; Celecoxib; Cyclooxygenase 1; C | 1997 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cycl | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan | 1999 |
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyc | 2000 |
New celecoxib derivatives as anti-inflammatory agents.
Topics: Acetic Acid; Animals; Carrageenan; Celecoxib; Chronic Disease; Crystallization; Cyclooxygenase 1; Cy | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
Topics: Analgesics; Animals; Benzamides; Benzopyrans; CHO Cells; Clinical Trials as Topic; Cricetinae; Crice | 2009 |
Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics.
Topics: Allergens; Analgesics; Animals; Antipyretics; Body Temperature; Drug Design; Fever; Guinea Pigs; Hyp | 2010 |
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Benzoquinones; Capsaicin; Carrageenan; Cyto | 2013 |
Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: synthesis and neuropharmacology.
Topics: Animals; Chemistry Techniques, Synthetic; Drug Discovery; Female; Hyperalgesia; Male; Mice; Neuralgi | 2013 |
Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Analgesics; Anti-Inflammatory Agents; Carrageenan; Cyclic GMP; Diterpenes; Edema; Freun | 2014 |
Antinociceptive properties of physalins from Physalis angulata.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp | 2014 |
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Crystallography, X-Ray; Cyclooxygenase 2 Inhibi | 2015 |
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.
Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Drug D | 2018 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In | 2020 |
Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Disease Models, Animal; Edema | 2020 |
Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy.
Topics: Analgesics; Animals; Benzamides; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug | 2021 |
Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Caco-2 Cells; Computer Simulation; Drug Desi | 2021 |
Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Hyperalgesia; Indomethacin; Interl | 2017 |
Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cells, Cultured; Cyclooxygenase 2; Dino | 2018 |
Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Disease Models, A | 2018 |
Paradoxical surrogate markers of dental injury-induced pain in the mouse.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cold Temperature; Dental Pulp; Diseas | 2013 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode | 2013 |
The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.
Topics: Amines; Analgesics; Animals; Antibodies; Chemokines; Cyclohexanecarboxylic Acids; Cyclooxygenase Inh | 2014 |
Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
Topics: Animals; Female; Hyperalgesia; Indomethacin; Male; Mice; Mice, Inbred BALB C; Minocycline; Paclitaxe | 2015 |
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; | 2015 |
Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chronic Disea | 2015 |
Naringenin reduces inflammatory pain in mice.
Topics: Analgesics; Animals; Cytokines; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; | 2016 |
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2016 |
Antihyperalgesic Effects of Indomethacin, Ketorolac, and Metamizole in Rats: Effects of Metformin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dipyrone; Dose-Response Relationship, | 2017 |
The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygen | 2008 |
Effect of cannabinoid receptor agonists on streptozotocin-induced hyperalgesia in diabetic neuropathy.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclooxygenase Inhibitors; Diabe | 2008 |
Nerve growth factor acts with the beta2-adrenoceptor to induce spontaneous nociceptive behavior during temporomandibular joint inflammatory hyperalgesia.
Topics: Adrenergic beta-2 Receptor Antagonists; Animals; Behavior, Animal; Carbazoles; Enzyme Inhibitors; Ep | 2008 |
PGE(2)-induced lasting nociception to heat: evidences for a selective involvement of A-delta fibres in the hyperpathic component of hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dimethyl Sulfoxide; Dinoprostone; Hot T | 2010 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; | 2009 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Differences between orofacial inflammation and cancer pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Carcinoma 256, Wa | 2010 |
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Rele | 2010 |
Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats.
Topics: Analgesics; Analysis of Variance; Animals; Celecoxib; Dinoprostone; Hyperalgesia; Indomethacin; Infl | 2010 |
Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Disease Models, Animal; Dos | 2010 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic | 2011 |
Intra-articular administration of tachykinin NK₁ receptor antagonists reduces hyperalgesia and cartilage destruction in the inflammatory joint in rats with adjuvant-induced arthritis.
Topics: Analgesics; Androstanes; Animals; Ankle Joint; Arthritis, Experimental; Benzimidazoles; Cartilage; F | 2011 |
Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2012 |
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment | 2012 |
Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice.
Topics: Androstanes; Animals; Antibodies, Monoclonal; Arthritis, Experimental; Benzimidazoles; Collagen Type | 2012 |
St. John's wort relieves pain in an animal model of migraine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Blotting, Western; Cold Temperat | 2013 |
The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Central Nervous S | 2013 |
Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activati | 2013 |
Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; D | 2002 |
Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dose-Respons | 2002 |
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug | 2002 |
[Prostaglandin inhibitor indomethacin inhibits afferent activities of Adelta and C units in the saphenous nerve of diabetic hyperalgesic rats].
Topics: Afferent Pathways; Animals; Diabetes Mellitus, Experimental; Femoral Nerve; Hyperalgesia; Indomethac | 2002 |
Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation.
Topics: Animals; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib | 2002 |
Reduced production of hyperalgesic substances by mononuclear cells from aged rats incubated with carrageenan: role of interleukin 2 and prostaglandins.
Topics: Aging; Animals; Carrageenan; Cell Separation; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme-Lin | 2003 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Model | 2004 |
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response | 2004 |
Peripheral P2X receptors and nociception: interactions with biogenic amine systems.
Topics: Adenosine Triphosphate; Adrenergic Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2004 |
Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Electroacupuncture; Freund's Adjuvant; Hot | 2004 |
A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Female; Hot Temperature | 2005 |
Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice.
Topics: Animals; Arthritis, Experimental; Bradykinin; Cyclooxygenase Inhibitors; Edema; Enzyme Inhibitors; H | 2005 |
Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Experimental; C | 2005 |
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP.
Topics: Adenosine Triphosphate; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; A | 2005 |
Anti-inflammatory effect of licofelone against various inflammatory challenges.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response R | 2006 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid An | 2006 |
The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzamides; Din | 2006 |
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrasentan; Bosentan; Carrageenan; Celecoxib; Cold | 2006 |
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; | 2006 |
Rat pain-related responses induced by experimental scorpion BmK sting.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain | 2006 |
Pathogenesis of spinally mediated hyperalgesia in diabetes.
Topics: Aldehyde Reductase; Animals; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Disease Models, Anim | 2007 |
Action of cyclooxygenase inhibitors and a leukotriene biosynthesis inhibitor on cisplatin-induced acute and delayed emesis in the ferret.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; D | 2007 |
Bradykinin into amygdala induces thermal hyperalgesia in rats.
Topics: Amygdala; Animals; Behavior, Animal; Bradykinin; Bradykinin Receptor Antagonists; Citrates; Cyclooxy | 2007 |
TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor.
Topics: Animals; Antibodies; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagoni | 2007 |
Evaluation of the interaction between acemetacin and opioids on the hargreaves model of thermal hyperalgesia.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Codeine; Dat | 2007 |
Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Dos | 2008 |
Characterization of a model of chronic orofacial hyperalgesia in the rat: contribution of NA(V) 1.8.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-R | 2008 |
Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice.
Topics: Analgesics; Animals; Arthritis, Experimental; Benzeneacetamides; Cells, Cultured; Chemokine CXCL1; C | 2008 |
Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Synergism; | 2008 |
Analgesic action of indomethacin in rats with trypsin-induced hyperalgesia.
Topics: Analgesics; Animals; Female; Hyperalgesia; Hyperesthesia; Indomethacin; Rats; Trypsin | 1980 |
Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.
Topics: Animals; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Edema; Hyperalgesia; Indomethacin; Lysopho | 1981 |
Antinociceptive activity of filenadol on inflammatory pain.
Topics: Analgesics; Animals; Benzoquinones; Codeine; Formaldehyde; Hyperalgesia; Indomethacin; Inflammation; | 1995 |
Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcit | 1995 |
Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats.
Topics: Animals; Antibodies, Monoclonal; Basal Metabolism; Carrageenan; Disease Models, Animal; Female; Hype | 1995 |
The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine-induced mechanical hyperalgesia in the rat.
Topics: Animals; Bradykinin; Cytokines; Female; Hyperalgesia; Indomethacin; Injections, Intra-Articular; Int | 1994 |
S14080, a peripheral analgesic acting by release of an endogenous circulating opioid-like substance.
Topics: Adrenalectomy; Analgesics; Animals; Arginine; Dipyrone; Drug Tolerance; Edema; Endorphins; Fever; Hy | 1995 |
Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization.
Topics: Analgesia; Animals; Arginine; Carrageenan; Diclofenac; Dinoprostone; Drug Interactions; Enzyme Activ | 1994 |
Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disea | 1994 |
Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF).
Topics: Animals; Azepines; Bothrops; Crotalid Venoms; Dexamethasone; Diterpenes; Dose-Response Relationship, | 1994 |
Bradykinin initiates cytokine-mediated inflammatory hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atenolol; Bradykinin; Carrageenan; Cytokines; Dise | 1993 |
Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia.
Topics: Animals; Bradykinin; Dose-Response Relationship, Drug; Hindlimb; Hyperalgesia; Indomethacin; Inflamm | 1993 |
Analgesic effect of Ga-Al-As diode laser irradiation on hyperalgesia in carrageenin-induced inflammation.
Topics: Analgesia; Animals; Carrageenan; Hyperalgesia; Indomethacin; Inflammation; Laser Therapy; Male; Nalo | 1993 |
Mechanical hyperalgesia in streptozotocin-diabetic rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylate Cyclase Toxin; Animals; Diabetes Mellit | 1993 |
Development of hyperthermia and hyperalgesia following intracerebroventricular administration of endotoxin in the rat: effect of kinin B1 and B2 receptor antagonists.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Fever; Hyperalgesia; Indomethacin; Inflammatio | 1996 |
Oxaceprol, an atypical inhibitor of inflammation and joint damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dinoprostone | 1996 |
Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Experimental; C | 1996 |
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclo | 1997 |
The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia.
Topics: Animals; Cyclooxygenase Inhibitors; Edema; Foot; Freund's Adjuvant; Hyperalgesia; Indomethacin; Isoe | 1997 |
Bradykinin-induced knee joint incapacitation involves bradykinin B2 receptor mediated hyperalgesia and bradykinin B1 receptor-mediated nociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Behavior, Animal; Bradykinin; Bradykini | 1997 |
Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Dexamethasone; Endotoxins; Hyperalgesi | 1997 |
Apparent antinociceptive and anti-inflammatory effects of GYKI 52466.
Topics: Acetaminophen; Analgesics; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Arthritis, Experi | 1997 |
Involvement of interleukin-1 beta, nerve growth factor, and prostaglandin-E2 in the hyperalgesia induced by intraplantar injections of low doses of thymulin.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dexame | 1997 |
Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ben | 1997 |
Role of TNF-alpha but not NGF in murine hyperalgesia induced by parasitic infection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Female; Hyperalgesia; Indometh | 1997 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
Central antinociceptive effects of meloxicam on rat spinal cord in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; E | 1998 |
Modulation of bradykinin-induced mechanical hyperalgesia in the rat by activity in abdominal vagal afferents.
Topics: Animals; Bradykinin; Cyclooxygenase Inhibitors; Dinoprostone; Hyperalgesia; Indomethacin; Male; Neur | 1998 |
Effect of colchicine on nerve growth factor-induced leukocyte accumulation and thermal hyperalgesia in the rat.
Topics: Animals; Colchicine; Edema; Gout Suppressants; Hot Temperature; Hyperalgesia; Indomethacin; Leukocyt | 1998 |
Pharmacological analysis of cyclooxygenase-1 in inflammation.
Topics: Animals; Arthritis, Experimental; Blood Platelets; Carrageenan; Celecoxib; Cyclooxygenase 1; Cycloox | 1998 |
COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Cyclooxygen | 1998 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Bradykinin; Bradykinin Receptor Antagonists; Carrage | 1999 |
Hyperalgesia due to nerve injury: role of prostaglandins.
Topics: Animals; Cyclooxygenase Inhibitors; Functional Laterality; Hindlimb; Hyperalgesia; Indomethacin; Mal | 1999 |
The profile of FR140423, a novel anti-inflammatory compound, in yeast-induced rat hyperalgesia.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dose-Respons | 1999 |
Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antivenins; Azepines; Bo | 2000 |
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indo | 2000 |
Chronic intrathecal cannulation enhances nociceptive responses in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Catheterization | 2000 |
Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression Regula | 2000 |
Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway.
Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; | 2000 |
Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom.
Topics: Animals; Bradykinin; Crotalid Venoms; Cytokines; Edema; Hyperalgesia; Indomethacin; Male; Rats; Rats | 2001 |
Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat.
Topics: Acute Disease; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Cannabinoid Rece | 2002 |
Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis.
Topics: Animals; Arthritis; Body Weight; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitor | 2002 |
Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antineopl | 2002 |
Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Cyclooxygenase 1; Cycl | 2002 |
Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on UV-damaged skin.
Topics: Administration, Topical; Animals; Cell Survival; Depression, Chemical; DNA; Erythema; Female; Guinea | 1975 |
Serotonin is a directly-acting hyperalgesic agent in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hydroxyurea; Hype | 1992 |
New analgesic assay utilizing trypsin-induced hyperalgesia in the hind limb of the rat.
Topics: Animals; Hindlimb; Hyperalgesia; Hyperesthesia; Indomethacin; Male; Methysergide; Pain Measurement; | 1990 |
Cannabinoids and pain responses: a possible role for prostaglandins.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dronabinol; Female; Hot Temperature; Hyperalge | 1988 |
The role of the polymorphonuclear leukocyte in hyperalgesia.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Complement C5; Complement C5a; Humans; Hyperalgesia; H | 1985 |
Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Bucladesine; Carrageenan; Dinoprostone; Di | 1985 |
A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages.
Topics: Aminopyrine; Animals; Dipyrone; Escherichia coli; Hyperalgesia; Indomethacin; Macrophages; Mice; Noc | 1988 |
Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue.
Topics: Amino Acid Sequence; Analgesia; Animals; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Hyper | 1988 |
Interleukin-1 mimics the hyperalgesia induced by a factor obtained by macrophage lysis.
Topics: Animals; Carrageenan; Guinea Pigs; Hyperalgesia; Hyperesthesia; Indomethacin; Interleukin-1; Macroph | 1988 |
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
Topics: Animals; Carrageenan; Hot Temperature; Hyperalgesia; Hyperesthesia; Indomethacin; Male; Morphine; Pa | 1988 |