hydrogen sulfide has been researched along with Allodynia in 27 studies
Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intracolonic administration of NaHS, an H(2)S donor, evoked visceral pain-like nociceptive behavior and referred hyperalgesia in mice, an effect abolished by NNC 55-0396, a selective T-type Ca(2+)-channel blocker, or by knockdown of Ca(v)3." | 7.78 | Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice. ( Kawabata, A; Noguchi, Y; Okawa, Y; Sekiguchi, F; Tsubota-Matsunami, M, 2012) |
| "In the mice with cerulein-induced acute pancreatitis, the referred hyperalgesia was suppressed by NNC 55-0396 (NNC), a selective T-channel inhibitor; zinc chloride; or ascorbic acid, known to inhibit Ca(v)3." | 5.42 | Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. ( Fujimura, M; Kawabata, A; Nishimura, S; Sekiguchi, F; Terada, Y; Tsubota, M, 2015) |
| "Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)." | 5.39 | Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013) |
| "Mechanical hyperalgesia and allodynia were evaluated by the von Frey test in mice." | 5.38 | Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice. ( Aoki, Y; Kawabata, A; Kawaishi, Y; Matsumura, M; Matsunami, M; Okawa, Y; Okubo, K; Sekiguchi, F, 2012) |
| "Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be involved in a wide variety of processes including inflammation and nociception." | 3.80 | Upregulation of cystathionine-β-synthetase expression contributes to inflammatory pain in rat temporomandibular joint. ( Hu, S; Ju, Z; Meng, X; Miao, X; Wu, G; Xu, GY; Zhang, HH, 2014) |
| " Intracolonic administration of NaHS, an H(2)S donor, evoked visceral pain-like nociceptive behavior and referred hyperalgesia in mice, an effect abolished by NNC 55-0396, a selective T-type Ca(2+)-channel blocker, or by knockdown of Ca(v)3." | 3.78 | Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice. ( Kawabata, A; Noguchi, Y; Okawa, Y; Sekiguchi, F; Tsubota-Matsunami, M, 2012) |
| "Hydrogen sulfide (H₂S) functions as a neuromodulator, but whether it modulates visceral pain is not well known." | 3.78 | Upregulation of cystathionine β-synthetase expression contributes to visceral hyperalgesia induced by heterotypic intermittent stress in rats. ( Hu, S; Jiang, X; Qu, R; Wang, Y; Xiao, Y; Xu, GY, 2012) |
| "The development of neuropathic pain was assessed using von Frey hair (mechanical allodynia), pinprick (mechanical hyperalgesia) and cold acetone drop tests (cold allodynia)." | 1.62 | Beneficial effects of octreotide in alcohol-induced neuropathic pain. Role of H 2S, BDNF, TNF-α and Nrf2. ( Jiang, R; Wei, H, 2021) |
| "Hydrogen sulfide plays important regulatory roles in different physiological and pathological conditions." | 1.51 | Nrf2/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats. ( Chen, H; Chen, Y; Lian, N; Wang, Y; Xie, K; Yu, Y; Zhang, K, 2019) |
| "Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome." | 1.48 | Endogenous H ( Bo, Q; Cui, J; Du, J; Shi, B; Wang, W; Wang, Y; Yu, X; Zhao, H; Zhu, K; Zhu, Y, 2018) |
| "Hydrogen sulfide (H2S) is an endogenous neurotransmitter that importantly regulates various physiological and pathological events including pain signal transduction." | 1.43 | Upregulation of spinal NMDA receptors mediates hydrogen sulfide-induced hyperalgesia. ( Guo, YX; Jiang, YQ; Liu, FF; Wang, XL; Wu, YM; Zhao, S, 2016) |
| "In the mice with cerulein-induced acute pancreatitis, the referred hyperalgesia was suppressed by NNC 55-0396 (NNC), a selective T-channel inhibitor; zinc chloride; or ascorbic acid, known to inhibit Ca(v)3." | 1.42 | Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. ( Fujimura, M; Kawabata, A; Nishimura, S; Sekiguchi, F; Terada, Y; Tsubota, M, 2015) |
| "Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)." | 1.39 | Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013) |
| "Mechanical hyperalgesia and allodynia were evaluated by the von Frey test in mice." | 1.38 | Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice. ( Aoki, Y; Kawabata, A; Kawaishi, Y; Matsumura, M; Matsunami, M; Okawa, Y; Okubo, K; Sekiguchi, F, 2012) |
| "The H(2)S-evoked hyperalgesia was blocked by 5,5'-dithio-bis-(2-nitrobenzoic acid) (DTNB), an oxidizing agent, or ethosuximide and mibefradil, T-type Ca(2+) channel inhibitors." | 1.34 | Hydrogen sulfide as a novel nociceptive messenger. ( Ichida, S; Ishiki, T; Kawabata, A; Maeda, Y; Nagasawa, K; Nishikawa, H; Sekiguchi, F; Takahashi, T; Wada, T; Yoshida, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 22 (81.48) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Garattini, EG | 1 |
| Santos, BM | 1 |
| Ferrari, DP | 1 |
| Capel, CP | 1 |
| Francescato, HDC | 1 |
| Coimbra, TM | 1 |
| Leite-Panissi, CRA | 1 |
| Branco, LGS | 1 |
| Nascimento, GC | 1 |
| Jiang, R | 1 |
| Wei, H | 1 |
| Wang, W | 1 |
| Bo, Q | 1 |
| Du, J | 1 |
| Yu, X | 1 |
| Zhu, K | 1 |
| Cui, J | 1 |
| Zhao, H | 1 |
| Wang, Y | 5 |
| Shi, B | 1 |
| Zhu, Y | 1 |
| Roa-Coria, JE | 2 |
| Pineda-Farias, JB | 1 |
| Barragán-Iglesias, P | 2 |
| Quiñonez-Bastidas, GN | 1 |
| Zúñiga-Romero, Á | 1 |
| Huerta-Cruz, JC | 1 |
| Reyes-García, JG | 1 |
| Flores-Murrieta, FJ | 2 |
| Granados-Soto, V | 1 |
| Rocha-González, HI | 2 |
| Chen, H | 1 |
| Xie, K | 1 |
| Chen, Y | 1 |
| Lian, N | 1 |
| Zhang, K | 1 |
| Yu, Y | 1 |
| Feng, X | 1 |
| Zhou, YL | 1 |
| Meng, X | 2 |
| Qi, FH | 1 |
| Chen, W | 1 |
| Jiang, X | 3 |
| Xu, GY | 5 |
| Velasco-Xolalpa, ME | 1 |
| Godínez-Chaparro, B | 1 |
| Torres-López, JE | 1 |
| Araiza-Saldaña, CI | 1 |
| Navarrete, A | 1 |
| Miao, X | 1 |
| Wu, G | 1 |
| Ju, Z | 1 |
| Zhang, HH | 1 |
| Hu, S | 3 |
| Yang, HY | 1 |
| Wu, ZY | 1 |
| Bian, JS | 1 |
| Terada, Y | 1 |
| Fujimura, M | 1 |
| Nishimura, S | 2 |
| Tsubota, M | 2 |
| Sekiguchi, F | 9 |
| Kawabata, A | 9 |
| Kida, K | 1 |
| Marutani, E | 1 |
| Nguyen, RK | 1 |
| Ichinose, F | 1 |
| Syhr, KMJ | 1 |
| Boosen, M | 1 |
| Hohmann, SW | 1 |
| Longen, S | 1 |
| Köhler, Y | 1 |
| Pfeilschifter, J | 1 |
| Beck, KF | 1 |
| Geisslinger, G | 1 |
| Schmidtko, A | 1 |
| Kallenborn-Gerhardt, W | 1 |
| Kashfi, K | 1 |
| Chattopadhyay, M | 1 |
| Kodela, R | 1 |
| Tian, R | 1 |
| Yang, W | 1 |
| Xue, Q | 1 |
| Gao, L | 1 |
| Huo, J | 1 |
| Ren, D | 1 |
| Chen, X | 1 |
| Aoki, Y | 4 |
| Nishimoto, Y | 1 |
| Maeda, Y | 4 |
| Zhao, S | 1 |
| Liu, FF | 1 |
| Wu, YM | 1 |
| Jiang, YQ | 1 |
| Guo, YX | 1 |
| Wang, XL | 1 |
| Matsunami, M | 4 |
| Takahashi, T | 5 |
| Nishikawa, H | 3 |
| Fukushima, O | 1 |
| Ishikura, H | 1 |
| Tsujiuchi, T | 1 |
| Naruse, M | 1 |
| Kamanaka, Y | 1 |
| Winston, JH | 1 |
| Shenoy, M | 1 |
| Zhou, S | 1 |
| Chen, JD | 1 |
| Pasricha, PJ | 1 |
| Okubo, K | 3 |
| Mitani, K | 1 |
| Kanaoka, D | 1 |
| Ohkubo, T | 1 |
| Yamazaki, J | 1 |
| Fukushima, N | 1 |
| Yoshida, S | 2 |
| Matsumura, M | 1 |
| Kawaishi, Y | 1 |
| Okawa, Y | 2 |
| Tsubota-Matsunami, M | 1 |
| Noguchi, Y | 1 |
| Andersson, DA | 1 |
| Gentry, C | 1 |
| Bevan, S | 1 |
| Li, L | 1 |
| Xie, R | 1 |
| Yu, T | 1 |
| Xiao, Y | 2 |
| Gu, J | 1 |
| Hu, CY | 1 |
| Qu, R | 1 |
| Ishiki, T | 1 |
| Nagasawa, K | 1 |
| Wada, T | 1 |
| Ichida, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Perioperative Hydrogen Inhalation on Post-operative Pain and Inflammation Cytokines[NCT05476575] | 32 participants (Anticipated) | Interventional | 2021-10-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
27 other studies available for hydrogen sulfide and Allodynia
| Article | Year |
|---|---|
Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model.
Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Hyperalge | 2019 |
Beneficial effects of octreotide in alcohol-induced neuropathic pain. Role of H 2S, BDNF, TNF-α and Nrf2.
Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Cystathionine beta-Synthase; Cystathionine g | 2021 |
Endogenous H
Topics: Alkynes; Aminooxyacetic Acid; Analgesics; Animals; Cell Line; Cystathionine gamma-Lyase; Cystitis, I | 2018 |
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cystathionine beta-Synthase; Diabetes Mellitus, Experi | 2019 |
Nrf2/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats.
Topics: Animals; Cytokines; Heme Oxygenase (Decyclizing); Hydrogen Sulfide; Hyperalgesia; Male; Microglia; N | 2019 |
Hydrogen sulfide increases excitability through suppression of sustained potassium channel currents of rat trigeminal ganglion neurons.
Topics: Action Potentials; Animals; Cystathionine beta-Synthase; Hydrogen Sulfide; Hyperalgesia; Ion Channel | 2013 |
Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats.
Topics: Algorithms; Alkynes; Animals; Blood Glucose; Cystathionine gamma-Lyase; Cysteine; Data Interpretatio | 2013 |
Upregulation of cystathionine-β-synthetase expression contributes to inflammatory pain in rat temporomandibular joint.
Topics: Action Potentials; Animals; Cystathionine beta-Synthase; Electric Stimulation; Enzyme Inhibitors; Fr | 2014 |
Hydrogen sulfide inhibits opioid withdrawal-induced pain sensitization in rats by down-regulation of spinal calcitonin gene-related peptide expression in the spine.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Cell Line, Tumor; C | 2014 |
Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis.
Topics: Analysis of Variance; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; C | 2015 |
Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice.
Topics: Administration, Inhalation; Analgesics; Animals; Behavior, Animal; Hydrogen Sulfide; Hyperalgesia; I | 2015 |
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expr | 2015 |
NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic A | 2015 |
Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats.
Topics: Animals; Blood Glucose; Caspase 3; Diabetic Neuropathies; Heme Oxygenase-1; Hydrogen Sulfide; Hypera | 2016 |
Selective sensitization of C-fiber nociceptors by hydrogen sulfide.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Electric Stimulation; Extracellular Sig | 2016 |
Upregulation of spinal NMDA receptors mediates hydrogen sulfide-induced hyperalgesia.
Topics: Animals; Hydrogen Sulfide; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Asp | 2016 |
Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cerebellum; Disea | 2009 |
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.
Topics: Alkynes; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; | 2009 |
The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome.
Topics: Acetic Acid; Animals; Blotting, Western; Colon; Cystathionine beta-Synthase; Fluorescent Antibody Te | 2009 |
Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, T-Type; Hydrogen Sulfide; Hy | 2010 |
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Blotting, Western; Calcium Channels, T-Type; Cyclopr | 2011 |
Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Gene Silencing; Hydrogen Sulfide; Hyper | 2012 |
Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice.
Topics: Animals; Benzimidazoles; Calcium Channels, T-Type; Cyclopropanes; Female; Hydrogen Sulfide; Hyperalg | 2012 |
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide.
Topics: Alkynes; Animals; Calcium; Cells, Cultured; CHO Cells; Cold Temperature; Cricetinae; Cricetulus; Cys | 2012 |
Upregulation of cystathionine beta-synthetase expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation.
Topics: Animals; Cystathionine beta-Synthase; Female; Ganglia, Spinal; Hydrogen Sulfide; Hyperalgesia; Irrit | 2012 |
Upregulation of cystathionine β-synthetase expression contributes to visceral hyperalgesia induced by heterotypic intermittent stress in rats.
Topics: Animals; Cystathionine beta-Synthase; Enzyme Inhibitors; Hydrogen Sulfide; Hyperalgesia; Intestinal | 2012 |
Hydrogen sulfide as a novel nociceptive messenger.
Topics: Animals; Calcium Channels, T-Type; Hydrogen Sulfide; Hyperalgesia; Male; Nociceptors; Posterior Horn | 2007 |