capsaicin and Allodynia

capsaicin has been researched along with Allodynia in 714 studies

Research

Studies (714)

TimeframeStudies, this research(%)All Research%
pre-19904 (0.56)18.7374
1990's95 (13.31)18.2507
2000's304 (42.58)29.6817
2010's259 (36.27)24.3611
2020's52 (7.28)2.80

Authors

AuthorsStudies
Ann, J; Blumberg, PM; Choi, K; Esch, TE; Ha, HJ; Hwang, SW; Kim, H; Kim, HS; Kim, M; Kim, YH; Lee, J; Pearce, LV; Thorat, SA; Turcios, NA1
Gao, J; Guo, Y; Hu, X; Huang, H; Jin, Z; Li, Z; Liu, Z; Wang, K; Wang, Y; Zhang, L; Zhong, Y; Zong, X1
Blockeel, AJ; Caspani, O; Cosentino, C; Di Lionardo, A; Di Pietro, G; Di Stefano, G; Garcia-Larrea, L; Leone, C; Malara, E; Mollica, C; Mouraux, A; Phillips, KG; Sgro, E; Treede, RD; Truini, A; Valeriani, M1
Bang, SK; Cho, SJ; Choi, KH; Kang, SY; Ryu, Y; Seo, SY1
Blockeel, AJ; Caspani, O; Di Lionardo, A; Di Pietro, G; Di Stefano, G; Falco, P; Garcia-Larrea, L; Leone, C; Mouraux, A; Phillips, KG; Treede, RD; Truini, A1
Arora, V; Asgar, J; Chung, MK; Kumari, S; Li, T; Wang, S1
Gao, L; Gao, Y; Li, D; Liu, Q; Mo, X; Pang, P; Tian, Q; Wang, Y; Wei, X; Xie, C; Xiong, T; Yao, J; Zhang, Y; Zhong, B1
Andersen, OK; Arendt-Nielsen, L; Hugosdottir, R; Kasting, M; Mørch, CD1
Fischer, MJM; Reeh, PW1
Borghi, SM; Brasil-Silva, L; Casagrande, R; Chichorro, JG; Cunha, JM; Fattori, V; Ferraz, CR; Verri, WA; Zaninelli, TH1
Berg, KA; Chavera, TS; Clarke, WP; Jamshidi, RJ; Jennings, EM; LoCoco, PM; Smith, HR; Sullivan, LC1
Mickle, AD; Mohapatra, DP; Robilotto, GL; Shepherd, AJ1
Basedau, H; Jürgens, T; May, A; Ortlieb, L; Peng, KP1
Chen, H; Hachisuka, J; Ibinson, J; Koerber, HR; Ross, SE; Salsovic, J; Sheahan, TD; Smith, KM; Warwick, C1
Cobos, EJ; Egea, J; Entrena, JM; García, AG; López, MG; Maroto, M; Montell, E; Padín, JF; Vergés, J1
Fuseya, S; Ishida, K; Ishida, T; Ito, M; Kawamata, M; Sakamoto, A; Tanaka, S1
Garcia-Larrea, L; Hagiwara, K; Perchet, C; Salameh, C1
Jo, HJ; Kim, YH; Park, CK; Rahman, MM1
Kringel, D; Lötsch, J; Mayer, B1
Ishida, S; Kikuchi, K; Murata, M; Tagawa, Y1
Arendt-Nielsen, L; Curatolo, M; Graven-Nielsen, T; Schliessbach, J; Siegenthaler, A1
Guo, J; Song, Y; Tang, J; Tang, Z; Yang, Y; Yu, G; Zhu, C1
Bourojeni, FB; Davidova, A; Kania, A; Mogil, JS; Petitjean, H; Sharif-Naeini, R; Sotocinal, SG; Tsao, D1
da Silva, JT; Ro, JY; Tricou, C; Yang, D; Zhang, R; Zhang, Y1
Aguiar, DA; Chichorro, JG; Dos Reis, RC; Kopruszinski, CM; Nones, CFM1
Ferreiros, N; Geisslinger, G; Lötsch, J; Oertel, BG; Rossmanith, T; Walter, C; Wolters, M; Zinn, S; Zunftmeister, M1
Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS1
Andersen, EOL; Fischer, L; Gaspar, JC; Guilhen, VA; Lazzarim, MK; Polato, JJ; Sardi, NF; Tobaldini, G1
Artico, M; Giacomoni, C; Lattanzi, R; Maftei, D; Severini, C; Vellani, V1
Burton, EF; Campbell, CM; Fulton, BA; Letzen, JE; Nance, S1
Kawabata, A; Matsui, K; Sekiguchi, F; Terada, Y; Tsubota, M1
Hughes, SW; Strutton, PH; Ward, G1
Banik, RK; Johns, ME; Kabadi, RA; McAdams, B; Simone, DA; Uhelski, ML1
Acampora, G; Arout, CA; DeNegre, D; Koretski, J; Newcomb, J; Perrino, AC; Petrakis, IL; Ralevski, E1
Basra, M; Chan, C; Gomes, S; Hughes, SW; Parr, C; Strutton, PH; Wong, F1
Antunes, FTT; Caminski, ES; Dallegrave, E; de Freitas, LM; de Souza, AH; Gomez, MV; Junior, CADS; Pereira, EMR1
Aldossary, SA; Alsalem, M; Altarifi, A; Azab, B; El-Salem, K; Haddad, M; Jaffal, SM; Kalbouneh, H; Mustafa, AG1
Baumgärtner, U; C Rosenberger, D; Greffrath, W; Henrich, F; Magerl, W; Shabes, P; Treede, RD1
Cabeça, LF; Costa, JSR; Couto, VM; Franco, MKKD; Franz-Montan, M; Geraldes, DC; Oliveira-Nascimento, L; Paula, E; Riske, KA; Yokaychiya, F1
Curt, A; Hubli, M; Rosner, J; Scheuren, PS1
González-Anduaga, GM; López-Ortíz, M; Navarrete, A; Palomino-Hernández, O; Quiñonez-Bastidas, GN; Regla, I; Rocha-González, HI1
Bach, H; Carranza, A; Gorzalczany, SB; Rodríguez Basso, A; Zainutti, VM1
Anderson, T; Dodick, DW; Kopruszinski, CM; Navratilova, E; Porreca, F; Schwedt, TJ; Swiokla, J; Turnes, JM; Weinstein, TJ1
Lin, CL; Lu, CC; Lu, YY; Tsai, HP; Wu, CH; Wu, MK1
Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A1
Ferreira, J; Ferreira, MA; Lückemeyer, DD; Macedo-Júnior, SJ; Prudente, AS; Schran, RG; Silva, AM; Tonello, R1
Brix Finnerup, N; Caspani, O; Garcia-Larrea, L; Ho, I; Kostenko, A; Leone, C; Mouraux, A; Nochi, Z; Pickering, G; Quesada, C; Stouffs, A; Tracey, I; Treede, RD; Truini, A; Wittayer, M1
Hara, K; Haranishi, Y; Terada, T1
Allison, C; John Z, S; Korey, L1
Dorsey, SG; Greenspan, JD; Keaser, ML; Liu, Y; Meeker, TJ; Schmid, AC; Seminowicz, DA1
Chung, JM; Hankerd, K; La, JH; McDonough, KE; Tang, SJ; Wang, J1
Wallace, MS1
Casals-Diaz, L; Dolly, O; Edupuganti, OP; Meng, J; Moriarty, O; Nealon, J; Wang, J; Zurawski, T1
Birklein, F; Breimhorst, M; Diener, SA; Drummond, PD; Geber, C; Krämer, HH; Vogt, T1
Borbély, É; Dénes, Á; Gaszner, B; Helyes, Z; Hunyady, Á; Környei, Z; Scheich, B; Szőke, É; Szolcsányi, J; Vincze, P1
Araya, EI; Chichorro, JG; Cunha, JMD; Ferreira, LEN; Kopruszinski, CM; Nones, CFM1
Artacho-Cordón, A; Cendán, CM; Entrena, JM; González-Cano, R; Nieto, FR; Tejada, MÁ; Wood, JN1
Albuquerque, TR; Alcantara, IS; Araújo, AAS; Araújo-Filho, HG; Barreto, RSS; Coutinho, HDM; Martins, AOBPB; Menezes, IRA; Menezes, PP; Pereira, EWM; Quintans, JSS; Quintans-Júnior, LJ; Rezende, MM; Silva, BAF1
Geisslinger, G; Heinemann, S; Lerch, F; Lötsch, J; Oertel, BG; Ultsch, A1
Giesler, GJ; Khasabov, SG; Malecha, P; Noack, J; Simone, DA; Tabakov, J1
Attal, N; Ernault, E; Gálvez, R; Maihöfner, C; Moyle, G; Navez, ML; Nurmikko, TJ; Stoker, M1
Duff, EP; Löken, LS; Tracey, I1
Fahey, E; Gandhi, W; Nadeau, C; Price, RC; Qu, A; Schweinhardt, P; Stone, L; Tarnavskiy, R1
Albu, S; Haney, R; Meagher, MW; You, DS1
Gurtskaia, G; Nozadze, I; Tsagareli, MG; Tsiklauri, N1
Furman, AJ; Goodman, RN; Keaser, ML; Mazaheri, A; Meeker, TJ; Muthulingam, J; Prokhorenko, M; Rietschel, JC; Seminowicz, DA; Yoo, S1
Beitz, AJ; Kim, SJ; Kwon, SG; Lee, JH; Roh, DH; Yeo, JH; Yoon, SY1
Cruccu, G; Ernault, E; Haanpää, M; McBride, WT; Nurmikko, TJ; Riaz, FK1
Aloisi, AM; Bachiocco, V; Bennett, DLH; Bogdanov, YD; Bras, JT; Cox, JJ; Emery, EC; Follenfant, M; Gossage, SJ; Gras, M; Habib, AM; Houlden, H; Humphrey, J; Kolesnikov, A; Komine, Y; Le Cann, K; Li, S; Maniatis, N; Marsili, L; Matsuyama, A; Minett, MS; Okorokov, AL; Panov, KI; Pereira, V; Ponsolles, C; Ramirez, JD; Santana-Varela, S; Sikandar, S; Torres, JM; Wood, JN; Yamamori, T; Yamaoka, K; Zhao, J1
Chang, KC; Chao, CC; Chiang, H; Hsieh, ST; Hsueh, HW; Kan, HW; Lin, YH; Tseng, MT; Wu, SW1
Béjar, J; Chávez, D; Contreras-Hernández, E; Cortés, U; Glusman, S; Hernández, E; Martín, M; Reyes, P; Rudomin, P; Velázquez, E1
Baron, R; Binder, A; Enax-Krumova, EK; Geisslinger, G; Gierthmühlen, J; Henrich, F; Hüllemann, P; Klein, T; Lötsch, J; Magerl, W; Maier, C; Oertel, B; Schuh-Hofer, S; Tölle, TR; Treede, RD; Vollert, J1
Drewes, AM; Larsen, IM; Olesen, AE1
Christoph, T; Kögel, B; Peters, T; Schiene, K; Schröder, W1
Blum, R; Brack, A; Kloka, J; Martin, C; Mohammadi, M; Oehler, B; Rittner, HL1
Klumpp, DJ; Miller, RJ; Rosen, JM; Schaeffer, AJ; Woida, PJ; Yaggie, RE1
Davidova, A; Lesperance, LS; Macpherson, A; Mouchbahani-Constance, S; Petitjean, H; Prescott, SA; Sharif-Naeini, R1
Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM1
Gu, Y; Huang, LM; Li, G1
Aboud, M; Comai, S; De Gregorio, D; Enns, J; Gobbi, G; Lopez-Canul, M; Maione, S; McLaughlin, RJ; Ochoa-Sanchez, R; Posa, L1
Fischer, L; Lamana, MS; Miranda, J; Tambeli, CH; Tobaldini, G1
Barik, A; Bharucha-Goebel, D; Bönnemann, CG; Bushnell, MC; Case, L; Chesler, AT; Donkervoort, S; Foley, AR; Ghitani, N; Gordon, T; Lam, R; Liljencrantz, J; Necaise, A; Saade, D; Szczot, M; Thompson, JH1
Daou, I; Dubin, AE; Francisco, AG; Keenan, WT; Kühnemund, J; Lewin, GR; Loud, MC; Marshall, KL; Murthy, SE; Patapoutian, A; Schwaller, F1
Abdelaziz, R; Barry, AM; Gomez-Varela, D; Jahn, O; Kügler, S; Michel, N; Schmidt, M; Sondermann, JR1
Bjurstrom, MF; Finan, PH; Gonzalez, K; Irwin, MR; Remeniuk, B; Robinson, M; Smith, MT; Speed, TJ; Tompkins, DA1
Borbély, É; Botz, B; Helyes, Z; Kiss, T; Pintér, E; Szabadfi, K; Szolcsányi, J1
Baudouin, C; Ben-Dhaou, C; Melik Parsadaniantz, S; Ouimet, T; Poras, H; Reaux-Le Goazigo, A; Wurm, M1
Adamek, P; Heles, M; Palecek, J1
Curry, RS; Eisenach, JC; Harris, L; Street, LM1
Barragán-Iglesias, P; Flores-Murrieta, FJ; Granados-Soto, V; Huerta-Cruz, JC; Pineda-Farias, JB; Quiñonez-Bastidas, GN; Reyes-García, JG; Roa-Coria, JE; Rocha-González, HI; Zúñiga-Romero, Á1
Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E1
Lötsch, J; Weyer-Menkhoff, I1
Bereiter, DA; Iinuma, T; Iwata, K; Katagiri, A; Lee, J; Ohara, K; Okada, S; Saito, H1
Chong, J; Eilers, H; Guan, Z; Kawamata, T; Lee, J; Maruyama, T; Philipsen, S; Schumacher, M; Sharma, M; Sheehan, K; Xu, Z; Zavala, K1
Baycu, C; Bektur, E; Can, OD; Canbek, M; Ceyhan, E; Donmez, DB; Şahin, E1
Agelopoulos, K; Conrad, H; Hatt, H; Hidding, J; Lotts, T; Osada, N; Pereira, MP; Pogatzki-Zahn, E; Schmelz, M; Ständer, S1
Andersen, OK; Frahm, KS; Mørch, CD1
Boligon, AA; da Silva Brum, E; Dalenogare, DP; Damiani, AP; de Almeida, AS; de Andrade, VM; de David Antoniazzi, CT; de Oliveira Sardinha, TT; De Prá, SDT; Ferro, PR; Galvani, NC; Oliveira, SM; Rigo, FK; Strapazzon, G; Trevisan, G1
Duan, W; Fang, Y; Ma, C; Xie, Y; Zhu, J1
Linde, LD; Srbely, JZ1
Barr, GA; Kuburas, A; Luu, AKS; Marquez de Prado, B; Raj, NR; Recober, A; Rossi, HL1
Chen, W; Fu, W; Marvizon, JC; Taylor, BK1
Buijs, M; Gentgall, M; Hutchinson, MR; Kwok, YH; Rolan, P; Tuke, J; Williams, D1
Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A1
Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM1
Boucher, Y; Carstens, E; Carstens, MI; Merrill, AW; Sawyer, CM; Zanotto, KL1
Chen, HS; Li, FP; Li, XQ; Lin, Q; Liu, BJ; Qu, F; Wang, Y; Wen, WW1
Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE1
Bhattacharyya, MH; Bollag, WB; Clark, SP; Falls, G; Isales, CM; Johnson, M; Ma, F; Westlund, KN; Xie, D1
Dahl, JB; Petersen, KL; Rowbotham, MC; Werner, MU1
Btesh, J; Fischer, MJM; McNaughton, PA; Stott, K1
Bae, YC; Cho, YS; Chung, MK; Lee, J; Ro, JY; Zhang, X1
Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA1
Gu, JG; Ling, JX; Xu, GY; Zuo, X1
Akazawa, C; Ebine, T; Funakubo, M; Iwashita, T; Kayama, Y; Kuroi, T; Nakagawa, T; Okano, H; Sato, H; Shibata, M; Shibata, S; Shimizu, T; Suzuki, N; Toriumi, H; Wajima, K1
Khasabov, SG; Simone, DA1
Dolan, S; Goldie, M1
Córdova, MM; Montrucchio, DP; Santos, AR1
Alpizar, YA; Boonen, B; Gees, M; Nilius, B; Sanchez, A; Talavera, K; Voets, T1
Büchel, C; Geuter, S1
Baggio, CH; Cipriani, TR; da Silva, CF; de Souza, LM; Hamm, LA; Nascimento, AM; Nomura, EC; Rodrigues, MR; Werner, MF1
Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JL; Kohli, SK1
Wallace, MS; Wong, W1
Aschenbrenner, CA; Eisenach, JC; Houle, TT; Peters, CM; Ririe, D1
Andreev, YA; Bondarenko, DA; Dyachenko, IA; Grishin, EV; Kabanova, NV; Kolesnikov, SS; Korolkova, YV; Kotova, PD; Kozlov, SA; Murashev, AN; Rogachevskaja, OA; Skobtsov, DI1
Alleyne, RT; LeBlanc, BW; Lii, TR; Saab, CY; Silverman, AE1
Adamek, P; Kalynovska, N; Mrozkova, P; Palecek, J; Spicarova, D1
Akiyama, T; Carstens, E; Carstens, MI; Nagamine, M1
Chichorro, JG; Cruz, LS; Kopruszinski, CM1
Finnerup, NB; Gierthmühlen, J; Højlund, AP; Jensen, TS; Terkelsen, AJ1
Birklein, F; Schlereth, T1
Beasley, S; Mark, I; Smith, S; Smith, T; Sweitzer, SM1
Andresen, T; Arendt-Nielsen, L; Drewes, AM; Lassen, D; Nielsen, AK; Nilsson, M1
Baker, DG; Moeller-Bertram, T; Patel, P; Schilling, JM; Simmons, AN; Strigo, IA1
Di Giminiani, P; Herskin, MS; Petersen, LJ1
Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR1
Chen, CC; Chen, WN1
Creech, SK; Meagher, MW; Smith, JS; Vichaya, EG; You, DS; Young, EE1
Amaral, LS; Barreiro, EJ; Fraga, CA; Guimaraes, MZ; Lacerda, RB; Lima, CK; Miranda, AL; Quintas, LE; Santos, BL; Silva, RM; Silva, RV1
Bonin, RP; De Koninck, Y1
Cui, YY; Li, YQ; Qi, J; Shi, J; Wu, HH; Xu, H1
Doyle, AP; Gomez, R; Henry, MA; Jeske, NA; Rowan, MP; Szteyn, K1
Barrot, M; Barthas, F; Bohren, Y; Hugel, S; Petitjean, H; Schlichter, R; Yalcin, I1
Nurmikko, T; Poole, H; Prior, M; Sacco, P1
Iida, S; Maruhama, K; Mizutani, M; Sugimoto, T; Terayama, R; Tsuchiya, H1
Fan, H; Haines, D; Higgins, T; Howard, OM; Li, J; Lin, H; Oppenheim, JJ; Qi, J; Trivett, A; Wei, H; Zhao, Z1
Chichorro, JG; Hummig, W; Kopruszinski, CM1
Furukawa, A; Honda, K; Iwata, K; Kita, K; Noma, N; Shinoda, M1
Baron, R; Gierthmühlen, J; Jansen, O; Rempe, T; Riedel, C; Stroman, PW; Wolff, S1
Iida, S; Maruhama, K; Mizutani, M; Omura, S; Sugimoto, T; Terayama, R; Tsuchiya, H1
Barragán-Iglesias, P; Granados-Soto, V; Martínez-Rojas, VA; Murbartián, J; Rocha-González, HI1
Harano, N; Hitomi, S; Inenaga, K; Kuramitsu, S; Matoba, M; Matsuo, K; Miyano, K; Ono, K; Ota, Y; Seta, Y; Uezono, Y; Yamaguchi, K1
Babić, A; Bach-Rojecky, L; Drinovac, V; Lacković, Z1
Athie, M; Dias, EV; Lamana, SM; Miranda, J; Parada, CA; Tambeli, CH1
Bölcskei, K; Borbély, É; Botz, B; Csepregi, JZ; Helyes, Z; Kenyér, T; Kereskai, L; Kiss, T; Mócsai, A; Pintér, E; Szolcsányi, J1
Moeller-Bertram, T; Silberberg, A; Wallace, MS1
Kumamoto, N; Shibata, Y; Ueda, T; Ugawa, S; Watanabe, M1
Ando, T; Baad-Hansen, L; Naganawa, T; Svensson, P1
Donahue, RR; Grace, PM; Griggs, RB; Morgenweck, J; Sutton, A; Taylor, BK; Watkins, LR1
Akopian, AN; Bierbower, SM; Dong, X; Geng, Y; Guan, Y; Jeske, NA; Mo, GC; Patel, KN; Tang, Z; Tiwari, V; Wang, Y; Weng, HJ; Zhang, J; Zheng, Q; Zou, W1
Andersen, HH; Arendt-Nielsen, L; Gazerani, P; Nikbakht, A; Poulsen, JN; Uchida, Y1
Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K1
Filipek, B; Sałat, K1
Finnerup, NB; Horjales-Araujo, E; Schaldemose, EL; Svensson, P1
Dang, D; Ono, K; Schmidt, BL; Viet, CT; Ye, Y1
Allen, KD; Caudle, RM; Jacobs, BY; Kloefkorn, HE; Lakes, EH; Neubert, JK; Rohrs, EL1
Baron, R; Enax-Krumova, EK; Maier, C; Mainka, T; Malewicz, NM; Treede, RD1
Curt, A; Jutzeler, CR; Kramer, JL1
Bogdanov, Y; Crow, M; Denk, F; Grant, AD; Kelleher, JH; Khovanov, N; McMahon, SB; Sharma, S; Wood, JN1
Greffrath, W; Henrich, F; Klein, T; Magerl, W; Treede, RD1
Loo, L; Mickle, AD; Mohapatra, DP; Shepherd, AJ1
Trbovich, M; Yang, H1
Chen, PB; Eskander, MA; Flores, ER; Gao, X; Green, DP; Hargreaves, KM; Jeske, NA; Por, ED; Ruparel, S1
Bressan, E; Chichorro, JG; Kopruszinski, CM; Reeh, PW; Reis, RC1
Geis, C; Lemmer, S; Schießer, P; Sommer, C; Üçeyler, N; Vanegas, H1
Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM1
Gan, YH; Hao, T; Kou, XX; Ma, XC; Wu, YW1
Aoki, S; Dai, Y; Iwaoka, E; Kogure, Y; Matsuyoshi, N; Noguchi, K; Wang, S; Yamamoto, S1
Groneberg, AH; Klein, T; Mouraux, A; Pfau, DB; Treede, RD; van den Broeke, EN1
Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y1
Baron, R; Binder, A; Hüllemann, P; Nerdal, A; Shao, YQ; Watfeh, R1
Andersson, J; Kong, Y; Mezue, M; Tracey, I; Wanigasekera, V1
Artola, A; Bourgois, N; Dallel, R; Peirs, C1
Davletov, B; Ferrari, E; Geranton, SM; Hunt, SP; Leese, C; Maiarú, M; Mangione, AS; Obara, I; Tassorelli, C1
Andoh, T; Kuraishi, Y; Sakamoto, A1
Li, X; Ma, Y; Sun, L; Wang, T; Wang, X; Zhang, Y1
Hall, BE; Jendryke, T; Kulkarni, AB; Milenkovic, VM; Nordmann, GC; Prochazkova, M; Schladt, M; Wetzel, CH1
Hoffmann, T; Lattanzi, R; Maftei, D; Negri, L; Reeh, PW1
Creech, SK; Meagher, MW; You, DS1
Abaei, M; Auer, DP; Chapman, V; Prior, M; Sagar, DR; Spicer, CH; Stockley, EG1
Chen, HS; Li, W; Li, XQ; Liu, BJ; Lu, Y; Wang, JX; Zhou, ZH1
Dickenson, AH; Iannetti, GD; Lee, MC; Liang, M; O'Neill, J1
Egbuniwe, O; Renton, T; Yilmaz, Z1
Buitenweg, JR; Doll, RJ; Groeneveld, GJ; Hay, JL; van Amerongen, G; Veltink, PH1
Bradshaw, H; Carey, LM; Cornett, B; Hohmann, AG; Leishman, E; Mackie, K; Slivicki, RA1
Itomi, Y; Kawamura, T; Tsukimi, Y1
Acampora, G; Arout, CA; Koretski, J; Limoncelli, D; Newcomb, J; Perrino, AC; Petrakis, IL; Ralevski, E1
Borbély, É; Helyes, Z; Kemény, Á; Markovics, A; McDougall, JJ; Pintér, E; Quinn, JP; Sándor, K; Szolcsányi, J1
Baron, R; Binder, A; Dierschke, R; Förster, M; Großkopf, M; Helfert, S; Hüllemann, P; Keller, T1
Asad, AB; Baumgartner, R; Chin, CL; Derbyshire, SW; Evelhoch, JL; Feng, D; Henry, B; Houghton, A; Jensen, A; Manigbas, E; Seah, S1
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Bach, FW; Brown, J; Chizh, BA; Gottrup, H; Jensen, TS; Juhl, G; Kristensen, AD; Lai, R1
Beswick, PJ; Bingham, S; Bountra, C; Brown, T; Campbell, IB; Chessell, IP; Clayton, N; Collins, SD; Davey, PT; Goodland, H; Gray, N; Haslam, C; Hatcher, JP; Hunter, AJ; Lucas, F; Murkitt, G; Naylor, A; Pickup, E; Sargent, B; Stevens, A; Stratton, SC; Summerfield, SG; Wiseman, J1
Cadiou, H; Jones, NG; McMahon, SB; McNaughton, P; Slater, R1
Bannon, AW; Doherty, EM; Gavva, NR; Immke, D; Klionsky, L; Louis, JC; Norman, MH; Porreca, F; Qu, Y; Tamir, R; Treanor, JJ; Vanderah, TW; Wang, J; Wild, KD; Zhang, TJ; Zhu, D1
Dai, Y; Fukuoka, T; Mashimo, T; Mizushima, T; Noguchi, K; Obata, K; Tokunaga, A; Yamanaka, H1
Dahl, JB; Dirks, J; Duedahl, TH; Larsen, NE; Petersen, KB; Romsing, J1
Casey, KL; Lorenz, J1
Caterina, M; Cowan, A; Inan, S; Oppenheim, JJ; Rogers, TJ; Sun, R; Wang, JM; Zhang, N1
Andersen, OK; Arendt-Nielsen, L; Eisenberg, E; Pud, D; Yarnitsky, D2
Brooks, JCW; Iannetti, GD; Tracey, I; Wise, RG; Zambreanu, L1
Iadarola, M; Karai, L; Lonser, RR; Olah, Z; Oldfield, EH; Tender, GC; Walbridge, S1
Breese, NM; George, AC; Pauers, LE; Stucky, CL1
Dougherty, PM; Weng, HR1
El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ1
Bach-Rojecky, L; Lacković, Z1
Cervero, F; Galan, A1
Dolan, RJ; Driver, J; Kalisch, R; Koltzenburg, M; Seymour, B; Stephan, KE; Wiech, K1
Eggenreich, U; Gschanes, A; Reitmeir, P; Schaffler, K1
Borrelli, E; Erbs, E; Mansikka, H; Pertovaara, A1
Asai, H; Nagamine, K; Ozaki, N; Shinoda, M; Sugiura, Y; Tohnai, I; Ueda, M1
Chapman, V; Kelly, S; Kendall, DA; Millns, PJ; O'Shaughnessey, CT; Sagar, DR1
Arendt-Nielsen, L; Gazerani, P1
Handwerker, HO; Maihöfner, C1
Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G1
Joshi, PG; Lakshmi, S1
Jones, TL; Sorkin, LS1
Baamonde, A; Hidalgo, A; Juarez, L; Lastra, A; Menéndez, L1
Laurito, CE; Lu, Y; Pappas, GD; Peters, MC; Vota-Vellis, G; Wilson, SP; Yeomans, DC1
Clapp, DW; Hingtgen, CM; Roy, SL1
Hohmann, AG; Nackley, AG; Neely, MH; Piña, J1
Buchanan, TJ; Huggins, JP; Iannetti, GD; Smart, TS; Tracey, I; Vennart, W; Wise, RG; Zambreanu, L1
Andersen, OK; Arendt-Nielsen, L; Miyazawa, A; Sumikura, H; Yucel, A1
Pöyhiä, R; Vainio, A1
Sun, RQ; Tu, YJ; Willis, WD; Yan, JY1
Chen, M; Gu, JG; Ling, J; Xing, H1
Hammer, J1
Jensen, MT; Petersen, KL1
Beltramo, M; Bernardini, N; Bertorelli, R; Campanella, M; Fredduzzi, S; Nicolussi, E; Reggiani, A1
Arendt-Nielsen, L; Chen, HS; Graven-Nielsen, T; He, X; Lei, J; Wang, Y; Wei, XZ; Wen, WW; You, HJ1
Ishiki, T; Kanke, T; Kawabata, A; Kawao, N; Kitano, T; Masuko, T; Matsunami, M; Saito, N; Satoh, R1
Caudle, RM; Malphurs, W; Neubert, JK; Rossi, HL; Vierck, CJ1
Arendt-Nielsen, L; Drewes, AM; Gazerani, P; Staahl, C1
Beneforti, P; Lazzeri, M; Malagutti, S; Spinelli, M; Turini, D1
Baad-Hansen, L; Jensen, TS; List, T; Svensson, P1
Castañeda-Hernandez, G; Lawand, NB; Lin, Q; Valencia-de Ita, S; Willis, WD1
Balan, C; Bannon, AW; Bo, Y; Dominguez, C; Fotsch, C; Gavva, NR; Gore, VK; Klionsky, L; Ma, VV; Norman, MH; Ognyanov, VI; Qian, YX; Tamir, R; Treanor, JJ; Wang, X; Xi, N; Xu, S; Zhu, D1
Bowles, WR; Harding-Rose, C; Hargreaves, KM; Sabino, M1
Colucci, M; De Felice, M; Giannini, E; Lattanzi, R; Margheriti, F; Melchiorri, P; Negri, L; Porreca, F; Tian, H; Vellani, V1
Amadesi, S; Barajas-Lopez, C; Bautista, F; Bunnett, NW; Chapman, K; Cottrell, GS; Divino, L; Grady, EF; Karanjia, R; Vanner, S; Vergnolle, N1
Kuramasu, A; Mobarakeh, JI; Sakurada, S; Takahashi, K; Yanai, K1
Alt, A; Bleakman, D; Dominguez, E; Iyengar, S; Jones, CK; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM1
Chapman, V; Marsden, CA; Morris, PG; Moylan Governo, RJ; Prior, MJ1
Imamura, Y; Iwata, K; Meng, ID; Ogawa, A; Ren, K1
Capra, NF; Ro, JY1
Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O1
Ikemi, Y; Imagawa, T; Ito, S; Murakami, M; Ohta, T; Otsuguro, K1
Albers, KM; Cornuet, P; Davis, BM; Frye, R; Koerber, HR; Malin, SA; Molliver, DC1
Cichewicz, DL; Haller, VL; Welch, SP1
Kumar, K; Polston, GR; Wallace, MS1
Amaya, F; Barrett, L; Lin, CR; Samad, TA; Takada, J; Wang, H; Woolf, CJ1
Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C1
Ispirescu, JS; Scanlon, GC; Schulteis, G; Wallace, MS1
Baad-Hansen, L; Brandsborg, B; Jensen, TS; Juhl, GI; Svensson, P1
Frymoyer, AR; Petersen, KL; Rowbotham, MC1
Baron, R; Chung, JM; Chung, K; Kim, HK; Lee, I; Schattschneider, J1
Colleoni, M; Comelli, F; Costa, B; Giagnoni, G; Trovato, AE1
Bradesi, S; Hicks, GA; Lao, L; Lee, K; Mayer, EA; McLean, PG; Winchester, WJ1
Jang, JH; Kim, DW; Kim, KH; Lee, WT; Leem, JW; Nam, TS; Park, KA1
Arendt-Nielsen, L; Chen, HS; He, X; Wang, Y; Wen, WW; You, HJ1
Barrett, AC; Lomas, LM; Lysle, DT; Picker, MJ; Terner, JM1
Baron, R; Binder, A; Hedderich, J; Schattschneider, J; Wasner, G; Zum Buttel, I1
Dai, Y; Fukuoka, T; Katsura, H; Kobayashi, K; Mashimo, T; Mizushima, T; Noguchi, K; Obata, K; Sakurai, J; Yamanaka, H1
Medley, D; Naniwadekar, A; Pasricha, PJ; Shenoy, M; Winston, J1
Chung, K; Gao, X; Kim, HK; Mo Chung, J1
Finnerup, NB; Jensen, TS; Johannesen, IL; Pedersen, LH; Terkelsen, AJ1
Chung, JM; Chung, K; Kim, HK; Kim, JH; Lee, I1
Aiello-Lammens, M; Becerra, L; Borsook, D; Morris, S; Moulton, EA; Pendse, G; Strassman, A1
Birklein, F; Fondel, R; Geber, C; Krämer, HH; Rolke, R; Sommer, C; Treede, RD1
Althaus, M; Hanschmann, A; Klein, T; Magerl, W; Treede, RD1
Bigalke, H; Blersch, W; May, A; Opatz, O; Schulte-Mattler, WJ; Wohlfahrt, K1
Baron, R; Naleschinski, D; Wasner, G1
Benedek, G; Horvath, G; Kekesi, G; Nagy, E1
Gyires, K; Helyes, Z; László, J; Sándor, K; Szolcsányi, J1
Fuchs, A; Hogan, QH; Rigaud, M1
Amadesi, S; Bunnett, NW; Chapman, K; Cottrell, GS; Gedda, K; Hollenberg, MD; Knecht, W; Mohlin, J; Peterson, A; Skåregärde, A; Vergnolle, N1
Pasricha, PJ; Pendyala, S; Shenoy, M; Winston, JH; Xu, GY; Yin, H1
Banerjee, B; Mannem, A; Miranda, A; Nordstrom, E; Sengupta, JN; Smith, C1
Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY1
Capra, NF; Lee, J; Ro, JY; Zhang, Y1
Birchmeier, C; Erdmann, B; Frahm, C; Garratt, AN; Gassmann, M; Griffel, C; Lewin, GR; Milenkovic, N1
Abramson, I; Atkinson, JH; Bentley, H; Gouaux, B; Lazzaretto, D; Schulteis, G; Wallace, M; Wolfson, T1
Chen, M; Gu, JG; Ling, J; Tan, W; Xing, H1
Chen, HS; Hou, S; Tang, JG; Wang, X; Yuan, W; Zhou, X1
Abu-Asab, M; Iadarola, MJ; Jenkins, AC; Karai, LJ; Mannes, AJ; Neubert, JK; Zawatski, L1
Knotkova, H; Pappagallo, M; Szallasi, A1
Chiang, H; Hsieh, ST; Hsieh, YL; Tseng, TJ1
Lomas, LM; Picker, MJ; Terner, JM1
Brand, A; Erdmann, B; Heppenstall, PA; Hu, J; Jüttner, R; Laurito, CE; Lewin, GR; Lu, Y; Milenkovic, N; Park, TJ; Smith, ES; Wetzel, C; Wilson, SP1
Hwang, SJ; Kim, E; Kim, J; Kim, SM; Lee, SE; Shin, HK1
Engert, S; Petersen, M; Schwab, A; Wendland, JR1
Helmchen, C; Leyendecker, S; Mohr, C1
Chung, K; Lee, I; Mo Chung, J; Schwartz, ES1
Beitz, AJ; Khasabov, SG; Pacharinsak, C; Simone, DA1
Bautista, D; Julius, D1
Hironaka, K; Ogino, A; Ozaki, N; Shinoda, M; Sugiura, Y; Urano, H; Yasui, M1
Andratsch, M; Bluethmann, H; Blumer, MJ; Constantin, CE; Davis, JB; Ji, RR; Kress, M; Mair, N; Sailer, CA; Scherbakov, N; Xu, ZZ1
Furuse, S; Ji, W; Kawamata, T; Namiki, A; Niiyama, Y; Yamamoto, J1
Brennan, TJ; Gavva, NR; Wu, C1
Bevan, S; Campbell, EA; Winter, J1
Drummond, PD7
Kinnman, E; Levine, JD1
Handwerker, HO; Ringkamp, M; Schmelz, M; Schmidt, R; Torebjörk, HE1
Dubner, R; Ren, K; Ruda, MA; Williams, GM1
Campbell, JN; Cervero, F; Meyer, RA1
Handwerker, HO; Kilo, S; Koltzenburg, M; Schmelz, M1
Andreev, N; Dray, A; Urban, L1
Davis, A; Perkins, MN1
Risberg, T; Wist, E1
Cole, JD; Treede, RD1
Brune, K; Forster, C; Geisslinger, G; Handwerker, HO; Kilo, S1
Andersen, OK; Arendt-Nielsen, L; Gracely, RH1
Gold, MS; Levine, JD; Reichling, DB; Shuster, MJ1
Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E1
Campbell, JN; Davis, KD; Filloon, TG; Meyer, RA; Pappagallo, M; Turnquist, JL1
Andersen, OK; Arendt-Nielsen, L; Jensen, TS1
Cervero, F; Laird, JM1
Bennett, GJ; Gracely, RH; Max, MB; Sang, CN1
Andersen, OK; Arendt-Nielsen, L; Bjerring, P; Felsby, S; Jensen, TS; Nicolaisen, L1
Davis, AJ; Perkins, MN1
Kress, M; Schmelz, M1
Allard, BL; Gilchrist, HD; Simone, DA1
Bennett, GJ; Liu, M; Max, MB; Parada, S; Rowan, JS1
Ali, Z; Campbell, JN; Meyer, RA1
Laitin, S; Licht, D; Wallace, MS; Yaksh, TL1
Curry, R; Eisenach, JC; Hood, DD; Tong, C1
Sluka, KA2
Cruwys, SC; Kidd, BL; Morris, VH1
Bushnell, MC; Chen, CC; Kupers, RC1
Vandam, LD1
Allen, BJ; Daughters, RS; Ghilardi, JR; Honore, P; Lappi, DA; Li, J; Mantyh, PW; Rogers, SD; Simone, DA; Wiley, RG1
Mansikka, H; Pertovaara, A1
Bunnett, NW; Grady, EF; Martínez, V; Marvizón, JC; Mayer, EA1
Cruwys, S; Garrett, NE; Malcangio, M; Tomlinson, DR1
Ishikawa, T; Menniti, FS; Mizutani, M; Nagahisa, A; Shimada, K; Shinjo, K; Taniguchi, K1
Alleva, E; Aloe, L; Cirulli, F; De Acetis, L; Padoa Schioppa, C1
Magerl, W; Treede, RD; Wilk, SH1
Hargreaves, KM; Kilo, S; Richardson, JD1
Lin, Q; McAdoo, DJ; Willis, WD; Wu, J1
Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR1
Andersen, OK; Arendt-Nielsen, L; Mohammadian, P1
Bennett, GJ; Gracely, R; Liu, M; Max, MB; Sethna, NF1
Andersen, OK; Arendt-Nielsen, L; Kauppila, T; Mohammadian, P; Nielsen, J1
D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Tonussi, CR1
Bennett, GJ; Gracely, RH; Liu, M; Max, MB; Robinovitz, E1
Cruwys, S; Kidd, B; Morris, V1
Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA1
Arendt-Nielsen, L; Jensen, TS; Svensson, P; Witting, N2
Dougherty, MP; Lenz, AF; Willis, DW1
Caruso, R; Chappell, AS; Gracely, RH; Hostetter, MP; Lee, G; Max, MB; Sang, CN; Schoepp, DD; Whitcup, S1
Michael, LR; Southall, DM; Vasko, RM1
Kuraishi, Y; Sasaki, M; Tohda, C1
Atweh, SF; Jabbur, SJ; Kanaan, SA; Major, SC; Saadé, NE; Safieh-Garabedian, B1
Campero, M; Ochoa, J; Serra, J1
Kemper, RHA; Meijler, WJ; Spoelstra, MB; Ter Horst, GJ1
Hwang, SW; Jung, JY; Kwak, JY; Lee, WT; Oh, U1
Hamilton, SG; McMahon, SB; Wade, A1
Bian, D; Lai, J; Malan, TP; Ossipov, MH; Porreca, F1
Cui, M; Lin, Q; Palecek, J; Palecková, V; Peng, YB; Willis, WD; Wu, J1
Baron, R; Binder, A; Borgstedt, R; Fields, HL; Hastedt, E; Kopper, F; Levine, JD; Rowbotham, M; Schulte, H; Wasner, G1
Maibach, HI; Rowbotham, MC; Yosipovitch, G1
Andrews, K; Baranowski, A; Kinnman, E1
Bengiamin, R; Brennan, J; Bullis, C; Daughters, RS; Li, J; Simone, DA; Stucky, MW1
Mansikka, H; Raja, SN; Shiotani, M; Winchurch, R1
Kamei, J; Ohsawa, M2
Petersen, KL; Rowbotham, MC1
Cesare, P; McNaughton, PA; Moriondo, A; Vellani, V1
Mendell, LM; Shu, XQ1
Baron, R; Baron, Y; Disbrow, E; Roberts, TP2
Bennett, GJ; Byas-Smith, MG; Dubner, R; Gracely, RH; Max, MB; Robinovitz, E1
Calixto, JB; Ferreira, J; Santos, AR1
Bramwell, S; Field, MJ; Hughes, J; Singh, L1
Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ1
Magerl, W; Meyer, RA; Treede, RD; Ziegler, EA1
Blunk, JA; Koppert, W; Likar, R; Schmelz, M; Sittl, R; Zeck, S1
Calixto, JB; Filho, VC; Malheiros, A; Mendes, GL; Santos, AR; Yunes, RA1
Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J1
Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH1
Campbell, JN; Fuchs, PN; Meyer, RA1
Baron, R; Binder, A; Kopper, F; Wasner, G1
Handwerker, HO; Schmelz, M; Schmid, R; Torebjörk, HE1
Gibson, SJ; Helme, RD; Khalil, Z; McMeeken, JM; Zheng, Z1
Koppert, W; Ostermeier, N; Schmelz, M; Sittl, R; Weidner, C1
D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Souza, GE1
Arendt-Nielsen, L; Gottrup, H; Hansen, PO; Jensen, TS1
Ali, Z; Campbell, JN; Huang, JH; Meyer, RA; Travison, TG1
Hargreaves, KM; Kehl, LJ; Trempe, TM1
Atkinson, K; Bingham, S; Clapham, C; Davey, PT; Davis, JB; Grau, E; Gray, J; Gunthorpe, MJ; Harper, AJ; Harries, MH; Hatcher, JP; Hughes, SA; Latcham, J; Overend, P; Pugh, PL; Rance, K; Randall, A; Rogers, DC; Sheardown, SA1
Bhattacharjee, A; Hamilton, SG; McMahon, SB; Warburton, J; Ward, J1
Southall, MD; Vasko, MR1
Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C1
Inoue, K; Kita, A; Koizumi, S; Shigemoto, Y; Tsuda, M; Ueno, S1
Dahl, JB; Dirks, J; Fabricius, P; Petersen, KL; Rowbotham, MC1
Baron, R1
Kamei, J; Zushida, K2
Cirillo, R; Evangelista, S; Lippi, A; Maggi, CA; Manzini, S; Terracciano, R; Vieira, C1
Arendt-Nielsen, L; Bach, FW; Gottrup, H; Jensen, TS1
Buchheit, KH; Campbell, EA; Chaudhry, N; James, IF; Kane, S; Panesar, M; Patel, S; Sandells, B; Urban, L1
Dahl, JB; Jones, B; Petersen, KL; Rowbotham, MC; Segredo, V1
Arnold, MA; Patterson, SL; Sluka, KA1
Jaggar, SI; James, IF; Rice, AS; Scott, HC1
Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Roza, C1
Brandt, MR; Furness, MS; Mello, NK; Negus, SS; Rice, KC1
Inoue, K; Koizumi, S; Tsuda, M1
Itoh, M; Konemura, T; Kuraishi, Y; Sasaki, M; Sasamura, T; Tohda, C1
Chen, HS; Chen, J1
Masu, M; Tominaga, M; Wada, M1
Cervero, F; Garcia-Nicas, E; Laird, JMA; Martinez-Caro, L1
Sluka, KA; Wright, A1
Gillard, SE; Hammond, DL; Hurley, RW; Miller, RJ; Oh, SB; Tran, PB1
Benrath, J; Gillardon, F; Zimmermann, M1
Heitmiller, DR; Hodges, J; Johanek, LM; Nader, N; Simone, DA; Turner, M1
Yonehara, N; Yoshimura, M1
Fuchs, PN; Magerl, W; Meyer, RA; Treede, RD1
Elde, R; Fairbanks, CA; Guo, A; Simone, DA; Stone, LS; Wang, J1
Drummond, PD; Lipnicki, DM1
Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH1
Blockey, P; Drummond, PD; Finch, PM; Skipworth, S1
Chung, JM; Kim, HT; Lee, DH; Lee, SE; Park, SK1
Ma, QP1
Cervero, F; Garcia-Nicas, E; Laird, JMA1
Baranowski, AP; Harding, LM; Kinnman, E; Murphy, A1
Agashe, GS; Clark, JD; Davies, MF; Guo, TZ; Kingery, WS; Maze, M1
Leung, A; Ridgeway, B; Schulteis, G; Wallace, MS; Yaksh, TL1
Belmonte, C; Caprini, M; Carbonell, T; De Felipe, C; De La Pena, E; Ferrer-Montiel, A; García-Martinez, C; Gomis, A; Humet, M; Messeguer, A; Pérez-Paya, E; Planells-Cases, R; Sanchez-Baeza, F; Viana, F1
Doom, CM; Junger, H; Sorkin, LS; Yu, AL1
Hama, AT1
Baumgärtner, U; Hopf, HC; Klein, T; Magerl, W; Treede, RD1
Bradley, EL; Bright, CA; Kissin, I1
Fang, L; Lin, Q; Willis, WD; Wu, J1
Adhikari, SM; Kokayeff, A; Lariviere, WR; Laughlin, TM; Mogil, JS; Wan, Y; West, EE; Wilson, SG1
Al-Hayani, A; Bisogno, T; Chu, CJ; Davies, SN; De Petrocellis, L; Di Marzo, V; Fezza, F; Geppetti, P; Huang, SM; Krey, JF; Miller, JD; Petros, TJ; Tognetto, M; Trevisani, M; Walker, JM1
Hylden, JL; Noguchi, K; Ruda, MA1
Campbell, EA; Perkins, MN1
Campbell, JN; Meyer, RA; Raja, SN; Treede, RD1
LaMotte, RH; Lundberg, LE; Torebjörk, HE2
Brenton, W; Carr, RW; Delaney, CA; Kiln, JC; Pano, I; Rabavilas, A; Roberts, RG; Westerman, RA1
LaMotte, RH; Shain, CN; Simone, DA; Tsai, EF1
Baumann, TK; LaMotte, RH; Shain, CN; Simone, DA1
Chung, JM; LaMotte, RH; Oh, U; Owens, C; Simone, DA; Sorkin, LS; Willis, WD1
Barthó, L; Herz, A; Stein, C1
Seltzer, Z; Shir, Y1
Baumann, TK; LaMotte, RH; Simone, DA1
Cline, M; Culp, WJ; Dotson, R; Ochoa, J1
Nagy, JI; van der Kooy, D1
Coderre, TJ; Melzack, R1

Reviews

18 review(s) available for capsaicin and Allodynia

ArticleYear
Nobel somatosensations and pain.
    Pflugers Archiv : European journal of physiology, 2022, Volume: 474, Issue:4

    Topics: Capsaicin; Humans; Hyperalgesia; Ion Channels; Nobel Prize; Pain; Temperature; TRPA1 Cation Channel; TRPV Cation Channels

2022
Human surrogate models of central sensitization: A critical review and practical guide.
    European journal of pain (London, England), 2021, Volume: 25, Issue:7

    Topics: Animals; Capsaicin; Central Nervous System Sensitization; Humans; Hyperalgesia; Neuralgia; Pain Measurement

2021
Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:1

    Topics: Analgesia; Analgesics; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Nerve Fibers; Neural Conduction; Pain, Postoperative; Rats; TRPV Cation Channels

2008
TRPV1 in migraine pathophysiology.
    Trends in molecular medicine, 2010, Volume: 16, Issue:4

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Female; Humans; Hyperalgesia; Male; Mice; Migraine Disorders; Nociceptors; Rats; Trigeminal Ganglion; TRPV Cation Channels; United States

2010
Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch.
    British journal of anaesthesia, 2011, Volume: 107, Issue:4

    Topics: Administration, Topical; Analgesics; Animals; Capsaicin; Humans; Hyperalgesia; Nociceptors; Pain

2011
Intestinal gas: has diet anything to do in the absence of a demonstrable malabsorption state?
    Current opinion in clinical nutrition and metabolic care, 2012, Volume: 15, Issue:5

    Topics: Capsaicin; Diet; Dietary Carbohydrates; Dietary Fiber; Enterobacteriaceae; Gases; Humans; Hyperalgesia; Intestinal Diseases; Intestines; Irritable Bowel Syndrome; Malabsorption Syndromes; Prebiotics; Probiotics

2012
Long-term potentiation in spinothalamic neurons.
    Brain research. Brain research reviews, 2002, Volume: 40, Issue:1-3

    Topics: Animals; Capsaicin; Excitatory Amino Acids; Humans; Hyperalgesia; Long-Term Potentiation; Nerve Net; Neurotransmitter Agents; Phosphorylation; Receptors, Glutamate; Receptors, Neurotransmitter; Second Messenger Systems; Spinal Cord; Thalamus

2002
A comparison of the pharmacological modulation of hyperalgesia and bronchial hyperresponsiveness.
    Pulmonary pharmacology & therapeutics, 2003, Volume: 16, Issue:1

    Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Capsaicin; Humans; Hyperalgesia; Narcotics; Receptors, N-Methyl-D-Aspartate

2003
Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain.
    Expert opinion on therapeutic targets, 2003, Volume: 7, Issue:4

    Topics: Acute Disease; Adenosine Triphosphate; Afferent Pathways; Analgesics; Animals; Biopolymers; Capsaicin; Chronic Disease; Ganglia, Spinal; Gene Targeting; Humans; Hyperalgesia; Mice; Mice, Knockout; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Neurons; Nociceptors; Pain; Phenotype; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X3

2003
TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia.
    European journal of pharmacology, 2004, Oct-01, Volume: 500, Issue:1-3

    Topics: Animals; Capsaicin; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Hyperalgesia; Ion Channel Gating; Receptors, Drug

2004
Imaging of acute versus pathological pain in humans.
    European journal of pain (London, England), 2005, Volume: 9, Issue:2

    Topics: Acute Disease; Adult; Brain; Capsaicin; Humans; Hyperalgesia; Male; Pain; Physical Stimulation; Positron-Emission Tomography; Reference Values

2005
Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival?
    The Clinical journal of pain, 2008, Volume: 24, Issue:2

    Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Drug Administration Routes; Humans; Hyperalgesia; Molecular Structure; Pain, Intractable; Sensory System Agents; TRPV Cation Channels

2008
Capsaicin and pain mechanisms.
    British journal of anaesthesia, 1995, Volume: 75, Issue:2

    Topics: Analgesia; Animals; Capsaicin; Drug Resistance; Humans; Hyperalgesia; Nerve Degeneration; Nociceptors; Pain; Receptors, Drug

1995
Ion channels gated by heat.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Jul-06, Volume: 96, Issue:14

    Topics: Animals; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ion Channel Gating; Ion Channels; Nociceptors; Pain

1999
Neurotrophins and hyperalgesia.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Jul-06, Volume: 96, Issue:14

    Topics: Adult; Animals; Capsaicin; Ganglia, Spinal; Humans; Hyperalgesia; Nerve Growth Factors; Neurons; Nociceptors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Receptors, Drug; Receptors, Nerve Growth Factor

1999
[ATP receptors in pain].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 116, Issue:6

    Topics: Adenosine Triphosphate; Animals; Capsaicin; Electrophysiology; Ganglia, Spinal; Humans; Hyperalgesia; Nociceptors; Pain; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Signal Transduction

2000
Role of neurotransmitters in sensitization of pain responses.
    Annals of the New York Academy of Sciences, 2001, Volume: 933

    Topics: Animals; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Agonists; Haplorhini; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Long-Term Potentiation; Mechanoreceptors; Microdialysis; Models, Animal; Models, Neurological; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Processing, Post-Translational; Rats; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Signal Transduction; Spinothalamic Tracts; Substance P

2001
Peripheral and central mechanisms of cutaneous hyperalgesia.
    Progress in neurobiology, 1992, Volume: 38, Issue:4

    Topics: Animals; Capsaicin; Humans; Hyperalgesia; Mustard Plant; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Nociceptors; Physical Stimulation; Plant Extracts; Plant Oils; Rats; Skin; Skin Diseases; Skin Temperature; Spinothalamic Tracts

1992

Trials

126 trial(s) available for capsaicin and Allodynia

ArticleYear
Sumatriptan prevents central sensitization specifically in the trigeminal dermatome in humans.
    European journal of pain (London, England), 2022, Volume: 26, Issue:10

    Topics: Capsaicin; Central Nervous System Sensitization; Headache; Humans; Hyperalgesia; Migraine Disorders; Pain; Sumatriptan; Tryptamines

2022
A randomized, double-blinded, placebo-controlled, crossover study of the HCN channel blocker ivabradine in a capsaicin-induced pain model in healthy volunteers.
    Scientific reports, 2022, 10-14, Volume: 12, Issue:1

    Topics: Adult; Analgesics; Calcium Channel Blockers; Capsaicin; Cross-Over Studies; Female; Healthy Volunteers; Humans; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ivabradine; Male; Neuralgia; Nucleotides, Cyclic

2022
A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects.
    Basic & clinical pharmacology & toxicology, 2020, Volume: 126, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Analgesics; Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pregabalin; Young Adult

2020
Anodal transcranial direct current stimulation over the primary motor cortex attenuates capsaicin-induced dynamic mechanical allodynia and mechanical pain sensitivity in humans.
    European journal of pain (London, England), 2020, Volume: 24, Issue:6

    Topics: Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Motor Cortex; Transcranial Direct Current Stimulation

2020
A novel computational technique for the quantification of temporal summation in healthy individuals.
    Musculoskeletal science & practice, 2021, Volume: 54

    Topics: Capsaicin; Central Nervous System Sensitization; Chronic Pain; Humans; Hyperalgesia; Pain Measurement

2021
Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain.
    Pain medicine (Malden, Mass.), 2021, Dec-11, Volume: 22, Issue:12

    Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Male; Pain; Pregabalin

2021
Capsaicin 8% Patch Repeat Treatment in Nondiabetic Peripheral Neuropathic Pain: A 52-Week, Open-Label, Single-Arm, Safety Study.
    The Clinical journal of pain, 2017, Volume: 33, Issue:10

    Topics: Aged; Analgesics, Non-Narcotic; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Prospective Studies; Reflex; Sensation; Transdermal Patch; Treatment Outcome

2017
Superiority of capsaicin 8% patch versus oral pregabalin on dynamic mechanical allodynia in patients with peripheral neuropathic pain.
    European journal of pain (London, England), 2018, Volume: 22, Issue:4

    Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Pregabalin; Treatment Outcome; Young Adult

2018
The Effect of a Combination of Diclofenac and Methadone Applied as Gel in a Human Experimental Pain Model - A Randomized, Placebo-controlled Trial.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:2

    Topics: Administration, Cutaneous; Adult; Capsaicin; Chronic Pain; Cross-Over Studies; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Gels; Healthy Volunteers; Humans; Hyperalgesia; Injections, Intradermal; Male; Methadone; Middle Aged; Nerve Growth Factor; Pain Measurement; Placebos; Treatment Outcome; Young Adult

2018
PIEZO2 mediates injury-induced tactile pain in mice and humans.
    Science translational medicine, 2018, 10-10, Volume: 10, Issue:462

    Topics: Animals; Capsaicin; Chronic Disease; Disease Models, Animal; Humans; Hyperalgesia; Imaging, Three-Dimensional; Inflammation; Ion Channels; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neurons; Pain; Recombination, Genetic; Touch

2018
TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.
    The Clinical journal of pain, 2019, Volume: 35, Issue:4

    Topics: Acrolein; Adult; Capsaicin; Cold Temperature; Cross-Over Studies; Female; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Male; Menthol; Neuralgia; Pain Threshold; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels; Young Adult

2019
Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection.
    Brain, behavior, and immunity, 2013, Volume: 30

    Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Endotoxins; Humans; Hyperalgesia; Male; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Toll-Like Receptor 4

2013
Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats.
    Behavioural pharmacology, 2013, Volume: 24, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Edema; Furans; Ginkgolides; Hindlimb; Hyperalgesia; Inflammation; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sensory System Agents; Vocalization, Animal

2013
Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method.
    The journal of pain, 2014, Volume: 15, Issue:1

    Topics: Adult; Analgesics; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Threshold; Pregabalin; Young Adult

2014
Bilateral hypersensitivity to capsaicin, thermal, and mechanical stimuli in unilateral complex regional pain syndrome.
    Anesthesiology, 2014, Volume: 120, Issue:5

    Topics: Administration, Topical; Adolescent; Adult; Aged; Capsaicin; Complex Regional Pain Syndromes; Female; Hot Temperature; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Middle Aged; Pain Measurement; Young Adult

2014
Effect of written emotional disclosure on secondary hyperalgesia in women with trauma history.
    Psychosomatic medicine, 2014, Volume: 76, Issue:5

    Topics: Adolescent; Adult Survivors of Child Abuse; Bereavement; Capsaicin; Central Nervous System Sensitization; Depression; Disasters; Emotions; Female; Humans; Hyperalgesia; Irritants; Pain; Self Disclosure; Social Problems; Stress, Psychological; Survivors; Wounds and Injuries; Writing; Young Adult

2014
Repetitive transcranial magnetic stimulation over primary motor vs non-motor cortical targets; effects on experimental hyperalgesia in healthy subjects.
    BMC neurology, 2014, Sep-04, Volume: 14

    Topics: Adolescent; Adult; Brain; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Motor Cortex; Pain Threshold; Sensory System Agents; Transcranial Magnetic Stimulation; Young Adult

2014
Spinal fMRI reveals decreased descending inhibition during secondary mechanical hyperalgesia.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Neuralgia; Pontine Tegmentum; Radiography; Spinal Cord

2014
A randomized, double-blind, crossover study to evaluate the depth response relationship of intradermal capsaicin-induced pain and hyperalgesia in healthy adult volunteers.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:4

    Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Sensory System Agents; Young Adult

2015
Altered thermal grill response and paradoxical heat sensations after topical capsaicin application.
    Pain, 2015, Volume: 156, Issue:6

    Topics: Adolescent; Adult; Anxiety; Capsaicin; Female; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Sensory System Agents; Statistics, Nonparametric; Surveys and Questionnaires; Thermosensing; Young Adult

2015
Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development.
    Anesthesiology, 2016, Volume: 124, Issue:1

    Topics: Adult; Amines; Analgesics; Analgesics, Non-Narcotic; Brain; Capsaicin; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Ibuprofen; Magnetic Resonance Imaging; Male; Neuroimaging; Reproducibility of Results; Treatment Outcome; Young Adult

2016
Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.
    Experimental brain research, 2016, Volume: 234, Issue:9

    Topics: Adolescent; Adult; Aged; Capsaicin; Electric Stimulation; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Psychophysics; Skin; Young Adult

2016
Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:7

    Topics: Administration, Intravenous; Adult; Affect; Breath Tests; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Ethanol; Female; Humans; Hyperalgesia; Male; Young Adult

2016
Evaluation of the antihyperalgesic effect of tapentadol in two human evoked pain models - the TapCapMentho pilot trial.
    Expert opinion on pharmacotherapy, 2016, Volume: 17, Issue:13

    Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Neuralgia; Pain; Pain Measurement; Pain Threshold; Phenols; Pilot Projects; Tapentadol; Young Adult

2016
Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study.
    Pain, 2016, Volume: 157, Issue:10

    Topics: Adolescent; Adult; Analgesics; Capsaicin; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Pentoxifylline; Sensory System Agents; Tourniquets; Young Adult

2016
Agreement between quantitative and qualitative sensory testing of changes in oro-facial somatosensory sensitivity.
    Journal of oral rehabilitation, 2017, Volume: 44, Issue:1

    Topics: Adult; Capsaicin; Cross-Over Studies; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Mouth; Pain Measurement; Pain Threshold; Physical Stimulation; Sensory System Agents

2017
Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects.
    The journal of pain, 2008, Volume: 9, Issue:12

    Topics: Adolescent; Adult; Alkaloids; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Drug Administration Routes; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Hypnotics and Sedatives; Injections, Intradermal; Injections, Intravenous; Male; Middle Aged; Morphine; Pain; Pain Measurement; Placebos; Pregabalin; Treatment Outcome; Young Adult

2008
Capsaicin or menthol sensitization induces quantitative but no qualitative changes to thermal and mechanical pain thresholds.
    The Clinical journal of pain, 2009, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Antipruritics; Capsaicin; Female; Humans; Hyperalgesia; Male; Menthol; Middle Aged; Pain Measurement; Pain Threshold; Physical Stimulation; Young Adult

2009
Evoked human oesophageal hyperalgesia: a potential tool for analgesic evaluation?
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:2

    Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Esophagus; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Reproducibility of Results

2009
The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study.
    Pain, 2009, Volume: 144, Issue:1-2

    Topics: Adult; Aged; Aging; Analysis of Variance; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesia; Lidocaine; Male; Pain Measurement; Personality; Procaine; Psychophysics; Sex Factors; Time Factors; Young Adult

2009
Late sensory function after intraoperative capsaicin wound instillation.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Analgesics; Capsaicin; Double-Blind Method; Follow-Up Studies; Hernia, Inguinal; Humans; Hyperalgesia; Instillation, Drug; Intraoperative Care; Male; Middle Aged; Nerve Fibers; Pain Measurement; Pain Threshold; Pain, Postoperative; Placebos; Pressure; Sensation; Sensory System Agents; Sensory Thresholds; Surgical Mesh; Thermosensing; Touch; Treatment Outcome; Young Adult

2010
A comparison of two formulations of intradermal capsaicin as models of neuropathic pain in healthy volunteers.
    British journal of clinical pharmacology, 2009, Volume: 68, Issue:4

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adult; beta-Cyclodextrins; Capsaicin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Excipients; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Sensory System Agents; Sex Factors; Single-Blind Method; Skin; Time Factors; Young Adult

2009
Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans.
    The journal of pain, 2010, Volume: 11, Issue:7

    Topics: Administration, Topical; Adult; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Muscle, Skeletal; Myofascial Pain Syndromes; Pain Measurement; Pain Threshold; Physical Stimulation; Placebo Effect; Sensory Receptor Cells; Sensory System Agents; Young Adult

2010
Ethnic variations in facial skin neurosensitivity assessed by capsaicin detection thresholds.
    Contact dermatitis, 2009, Volume: 61, Issue:6

    Topics: Administration, Cutaneous; Adolescent; Adult; Asian People; Black People; Capsaicin; Dose-Response Relationship, Drug; Face; Female; Humans; Hyperalgesia; Irritants; Nociceptors; Sensory Thresholds; Single-Blind Method; Skin; Statistics, Nonparametric; White People

2009
A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:9

    Topics: Adult; Capsaicin; Dermatitis, Contact; Humans; Hyperalgesia; Irritants; Male; Pain; Skin; Sodium Dodecyl Sulfate

2010
A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia.
    Clinical pharmacokinetics, 2010, Volume: 49, Issue:12

    Topics: Acids; Administration, Oral; Adult; Analgesics, Opioid; Capsaicin; Cross-Over Studies; Double-Blind Method; Esophagus; Female; Humans; Hyperalgesia; Male; Middle Aged; Models, Biological; Oxycodone; Pain Measurement; Time Factors; Young Adult

2010
Effects of lidocaine patch on intradermal capsaicin-induced pain: a double-blind, controlled trial.
    The journal of pain, 2011, Volume: 12, Issue:3

    Topics: Anesthetics, Local; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Lidocaine; Pain; Pain Measurement; Pain Threshold; Time Factors; Transdermal Patch

2011
Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 108, Issue:4

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Capsaicin; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fentanyl; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Pain; Pain Measurement; Time Factors; Transdermal Patch; Young Adult

2011
Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain.
    British journal of pharmacology, 2011, Volume: 164, Issue:3

    Topics: Administration, Cutaneous; Analgesics; Analgesics, Opioid; Buprenorphine; Capsaicin; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fentanyl; Humans; Hyperalgesia; Male; Nerve Growth Factor; Pain; Pain Measurement; Skin; Young Adult

2011
Self-reported sleep duration associated with distraction analgesia, hyperemia, and secondary hyperalgesia in the heat-capsaicin nociceptive model.
    European journal of pain (London, England), 2011, Volume: 15, Issue:6

    Topics: Analgesia; Attention; Capsaicin; Humans; Hyperalgesia; Hyperemia; Pain Measurement; Pain Threshold; Self Report; Sleep; Video Games

2011
Antihyperalgesic efficacy of 5% lidocaine medicated plaster in capsaicin and sunburn pain models--two randomized, double-blinded, placebo-controlled crossover trials in healthy volunteers.
    Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:18

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Capsaicin; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Lidocaine; Neuralgia; Pain Measurement; Physical Stimulation; Sunburn; Treatment Outcome; Young Adult

2011
Sensory responses to injection and punctate application of capsaicin and histamine to the skin.
    Pain, 2011, Volume: 152, Issue:11

    Topics: Acute Pain; Capsaicin; Female; Histamine; Histamine Agonists; Humans; Hyperalgesia; Injections, Intradermal; Male; Nociceptors; Sensory System Agents; Skin

2011
Biomarkers for visceral hypersensitivity identified by classification of electroencephalographic frequency alterations.
    Journal of neural engineering, 2011, Volume: 8, Issue:5

    Topics: Acids; Adult; Biomarkers; Capsaicin; Colon, Sigmoid; Cross-Over Studies; Data Interpretation, Statistical; Electric Stimulation; Electroencephalography; Esophagus; Female; Humans; Hyperalgesia; Linear Models; Male; Middle Aged; Pain Perception; Pain Threshold; Regression Analysis; Reproducibility of Results; User-Computer Interface; Wavelet Analysis; Young Adult

2011
Increased contact heat pain and shortened latencies of contact heat evoked potentials following capsaicin-induced heat hyperalgesia.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2012, Volume: 123, Issue:7

    Topics: Adult; Capsaicin; Evoked Potentials, Somatosensory; Female; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Reaction Time; Sensory System Agents; Skin; Skin Temperature

2012
The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Minocycline; Pain; Pregabalin; Sciatica; Time Factors; Treatment Outcome

2012
NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia.
    Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:12

    Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Isoquinolines; Male; Pain; Pain Measurement; Prodrugs; Receptors, AMPA; Receptors, Kainic Acid; Sensory System Agents; Tetrazoles; Young Adult

2012
Amygdala activity contributes to the dissociative effect of cannabis on pain perception.
    Pain, 2013, Volume: 154, Issue:1

    Topics: Adult; Amygdala; Analgesics, Non-Narcotic; Antigens, Viral; Capsaicin; Cross-Over Studies; Dissociative Disorders; Double-Blind Method; Dronabinol; Heart Rate; Humans; Hyperalgesia; Male; Pain Perception; Placebos; Psychomotor Performance; Sensory System Agents; Young Adult

2013
Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:3

    Topics: Adult; Analgesics; Benzimidazoles; Cannabinoid Receptor Agonists; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Psychotropic Drugs; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulfonamides; Treatment Outcome; Young Adult

2013
Naloxone increases pain induced by topical capsaicin in healthy human volunteers.
    Pain, 2002, Volume: 99, Issue:1-2

    Topics: Administration, Topical; Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Synergism; Female; Humans; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Pain; Psychophysics; Receptors, Opioid

2002
Assessment of the reproducibility of intradermal administration of capsaicin as a model for inducing human pain.
    Pain, 2002, Volume: 99, Issue:1-2

    Topics: Analysis of Variance; Arm; Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Reproducibility of Results

2002
The effect of chronic oral desipramine on capsaicin-induced allodynia and hyperalgesia: a double-blinded, placebo-controlled, crossover study.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Adult; Antidepressive Agents, Tricyclic; Capsaicin; Cross-Over Studies; Desipramine; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Touch

2002
Dose response of intrathecal adenosine in experimental pain and allodynia.
    Anesthesiology, 2002, Volume: 97, Issue:4

    Topics: Adenosine; Administration, Topical; Adult; Aminophylline; Analgesics, Non-Narcotic; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Infusions, Intravenous; Injections, Spinal; Male; Middle Aged; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists

2002
Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation.
    Brain : a journal of neurology, 2003, Volume: 126, Issue:Pt 5

    Topics: Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Irritants; Male; Nociceptors; Pain; Prefrontal Cortex; Principal Component Analysis; Psychophysics; Regional Blood Flow; Regression Analysis; Skin; Tomography, Emission-Computed

2003
Chili pepper and rectal hyperalgesia in irritable bowel syndrome.
    The American journal of gastroenterology, 2003, Volume: 98, Issue:5

    Topics: Capsaicin; Capsicum; Colonic Diseases, Functional; Cross-Over Studies; Diet; Dilatation; Humans; Hyperalgesia; Pain Threshold; Rectal Diseases; Visceral Afferents

2003
Gut pain and hyperalgesia induced by capsaicin: a human experimental model.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Ileostomy; Ileum; Intestinal Mucosa; Male; Middle Aged; Pain; Pain Measurement; Statistics, Nonparametric

2003
Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:3

    Topics: Adult; Analgesics, Opioid; Capsaicin; Female; Humans; Hyperalgesia; Male; Nausea; Oxyhemoglobins; Pain Measurement; Piperidines; Remifentanil

2003
A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A.
    Neurology, 2003, Oct-14, Volume: 61, Issue:7

    Topics: Adult; Analgesics; Botulinum Toxins, Type A; Capsaicin; Double-Blind Method; Electric Stimulation; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Pain Threshold; Placebos; Reference Values; Skin; Treatment Outcome

2003
A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
    The journal of pain, 2003, Volume: 4, Issue:7

    Topics: Adult; Analgesics, Opioid; Anticonvulsants; Capsaicin; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Hot Temperature; Humans; Hydromorphone; Hyperalgesia; Lamotrigine; Pain; Pain Measurement; Piperidines; Remifentanil; Triazines

2003
The heat/capsaicin sensitization model: a methodologic study.
    The journal of pain, 2003, Volume: 4, Issue:3

    Topics: Adolescent; Adult; Capsaicin; Cross-Over Studies; Hot Temperature; Humans; Hyperalgesia; Male; Models, Neurological; Pain Measurement; Physical Stimulation; Reference Values; Reproducibility of Results; Skin; Time Factors

2003
A human model of intraoral pain and heat hyperalgesia.
    Journal of orofacial pain, 2003,Fall, Volume: 17, Issue:4

    Topics: Administration, Topical; Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Facial Pain; Female; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Mouth Mucosa; Pain Measurement; Sensory Thresholds; Statistics, Nonparametric; Surveys and Questionnaires

2003
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans.
    Clinical physiology and functional imaging, 2004, Volume: 24, Issue:2

    Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Injections, Subcutaneous; Ketamine; Lidocaine; Male; Pain; Skin

2004
Effect of the new H1-antagonist ReN1869 on capsaicin-induced hyperalgesia in human skin/Human phase-I trial using somatosensory evoked potentials induced by a CO2 laser.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:3

    Topics: Adult; Arousal; Capsaicin; Cross-Over Studies; Double-Blind Method; Electroencephalography; Evoked Potentials, Somatosensory; Histamine H1 Antagonists; Humans; Hyperalgesia; Lasers; Male; Pain Measurement; Piperidines; Skin

2004
[Differentiation of peripheral and central hyperalgesic effects of systemic procaine].
    Schmerz (Berlin, Germany), 2004, Volume: 18, Issue:3

    Topics: Anesthetics, Local; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Infusions, Parenteral; Injections, Subcutaneous; Nociceptors; Pain Measurement; Procaine; Time Factors

2004
Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 78, Issue:2

    Topics: Administration, Oral; Adult; Analysis of Variance; Capsaicin; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Lamotrigine; Male; Middle Aged; Pain Measurement; Pyrimidines; Sodium Channel Blockers; Sodium Channels; Triazines

2004
Analgesic effects of low-dose intravenous orphenadrine in the state of capsaicin hyperalgesia. A randomised, placebo-controlled, double-blind cross-over study using laser somatosensory evoked potentials obtained from capsaicin-irritated skin in healthy vo
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:10

    Topics: Adolescent; Adult; Analgesics; Antiparkinson Agents; Capsaicin; Double-Blind Method; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Injections, Intravenous; Irritants; Lasers; Male; Middle Aged; Orphenadrine; Pain Measurement; Peripheral Nervous System; Skin

2004
Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia.
    Anesthesiology, 2004, Volume: 101, Issue:6

    Topics: Adult; Amines; Analgesics; Capsaicin; Central Nervous System; Cyclohexanecarboxylic Acids; Double-Blind Method; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation

2004
Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect.
    Pain, 2005, Volume: 113, Issue:3

    Topics: Adolescent; Adult; Area Under Curve; Capsaicin; Cross-Over Studies; Dextromethorphan; Dextrorphan; Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Infusions, Intravenous; Male; Pain; Pain Measurement; Pain Threshold; Reaction Time; Time Factors; Treatment Outcome

2005
Modulation of pain processing in hyperalgesia by cognitive demand.
    NeuroImage, 2005, Aug-01, Volume: 27, Issue:1

    Topics: Adult; Attention; Capsaicin; Cognition; Female; Hot Temperature; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Pain; Psychomotor Performance; Reaction Time

2005
Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials fro
    Drugs in R&D, 2005, Volume: 6, Issue:4

    Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Diclofenac; Double-Blind Method; Drug Combinations; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Infusions, Intravenous; Lasers; Male; Middle Aged; Orphenadrine; Pain

2005
The impact of ethnic differences in response to capsaicin-induced trigeminal sensitization.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Adult; Asian People; Capsaicin; Humans; Hyperalgesia; Male; Outcome Assessment, Health Care; Pain Measurement; Pain Threshold; Trigeminal Nerve; White People

2005
Differential coding of hyperalgesia in the human brain: a functional MRI study.
    NeuroImage, 2005, Volume: 28, Issue:4

    Topics: Adult; Brain; Capsaicin; Cerebral Cortex; Echo-Planar Imaging; Female; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Pain Measurement; Physical Stimulation; Prefrontal Cortex; Psychophysics

2005
Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Dec-13, Volume: 102, Issue:50

    Topics: Adult; Amines; Analgesics; Analysis of Variance; Capsaicin; Central Nervous System; Cross-Over Studies; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Pain; Psychophysics

2005
Secondary heat hyperalgesia detected by radiant heat stimuli in humans: evaluation of stimulus intensity and duration.
    Somatosensory & motor research, 2005, Volume: 22, Issue:3

    Topics: Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Time Factors

2005
Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia.
    The Clinical journal of pain, 2006, Volume: 22, Issue:1

    Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Dissociative; Area Under Curve; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain Measurement; Time Factors

2006
Hyperalgesia against capsaicin in persons with un-investigated dyspepsia: potential as a new diagnostic test.
    Wiener klinische Wochenschrift, 2006, Volume: 118, Issue:1-2

    Topics: Adult; Capsaicin; Dyspepsia; Female; Humans; Hyperalgesia; Jejunum; Male; Pain Threshold; Reproducibility of Results; Sensitivity and Specificity

2006
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
    The journal of pain, 2006, Volume: 7, Issue:8

    Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Method; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glycine; Humans; Hyperalgesia; Indans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate

2006
The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Ketorolac; Male; Pain; Pain Measurement; Pain Threshold; Placebos

2006
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
    Pain, 2007, Volume: 129, Issue:1-2

    Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-Blind Method; Drug Administration Routes; Drug Administration Schedule; Female; Fentanyl; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain; Pain Measurement; Toothache

2007
Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers.
    The journal of pain, 2007, Volume: 8, Issue:1

    Topics: Adult; Analgesics, Opioid; Capsaicin; Dextromethorphan; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Morphine; Pain; Thigh

2007
Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia.
    European journal of pain (London, England), 2007, Volume: 11, Issue:7

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capsaicin; Cholinergic Agents; Cross-Over Studies; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Hyperalgesia; Indomethacin; Iontophoresis; Male; Neurons, Afferent; Nociceptors; Norepinephrine; Pain; Prostaglandins; Sodium Chloride; Vasodilation

2007
Reaction to topical capsaicin in spinal cord injury patients with and without central pain.
    Experimental neurology, 2007, Volume: 205, Issue:1

    Topics: Administration, Topical; Adult; Aged; Analgesics, Non-Narcotic; Autonomic Nervous System; Capsaicin; Cold Temperature; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Physical Stimulation; Spinal Cord Injuries; Thoracic Vertebrae

2007
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia.
    European journal of pain (London, England), 2008, Volume: 12, Issue:1

    Topics: Aminopyridines; Analgesics; Capsaicin; Cross-Over Studies; Cyclopentanes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Nervous System Diseases; Pain; Physical Stimulation; Receptors, N-Methyl-D-Aspartate; Treatment Outcome

2008
Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.
    Journal of the neurological sciences, 2007, Sep-15, Volume: 260, Issue:1-2

    Topics: Adult; Analgesics, Non-Narcotic; Botulinum Toxins, Type A; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Middle Aged; Neurotoxins; Nociceptors; Pain; Pain Measurement; Pain Threshold; Placebos; Prospective Studies; Sensory Receptor Cells; Skin

2007
Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.
    Anesthesiology, 2007, Volume: 107, Issue:5

    Topics: Adult; Analgesics, Non-Narcotic; Cannabinoids; Cannabis; Capsaicin; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Female; Humans; Hyperalgesia; Male; Marijuana Smoking; Neuropsychological Tests; Pain; Pain Measurement; Reference Values; Sensory System Agents; Sensory Thresholds; Time Factors

2007
A psychophysical study of secondary hyperalgesia: evidence for increased pain to input from nociceptors.
    Pain, 1994, Volume: 58, Issue:1

    Topics: Adult; Animals; Capsaicin; Cold Temperature; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Male; Mechanoreceptors; Nociceptors; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Wool

1994
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man.
    Pain, 1995, Volume: 62, Issue:2

    Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Dermatitis; Double-Blind Method; Female; Freezing; Humans; Hyperalgesia; Ibuprofen; Male; Skin; Stress, Mechanical; Treatment Outcome

1995
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
    Pain, 1995, Volume: 63, Issue:2

    Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intradermal; Ketamine; Male; Midazolam; Pain; Pain Threshold; Palliative Care; Placebos; Receptors, N-Methyl-D-Aspartate; Skin

1995
Mechanisms of allodynia: interactions between sensitive mechanoreceptors and nociceptors.
    Neuroreport, 1996, Jan-31, Volume: 7, Issue:2

    Topics: Adult; Axons; Capsaicin; Female; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Mechanoreceptors; Middle Aged; Mustard Plant; Nociceptors; Physical Stimulation; Plant Extracts; Plant Oils; Regional Blood Flow; Skin; Skin Physiological Phenomena; Vasodilation

1996
The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study.
    Pain, 1996, Volume: 66, Issue:1

    Topics: Adult; Anesthetics, Dissociative; Capsaicin; Double-Blind Method; Electric Stimulation; Electrophysiology; H-Reflex; Hot Temperature; Humans; Hyperalgesia; Ketamine; Lasers; Nociceptors; Pain Measurement; Pain Threshold; Placebos; Psychophysics; Reaction Time

1996
Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia.
    Neuroscience letters, 1996, Aug-16, Volume: 214, Issue:1

    Topics: Administration, Topical; Aspirin; Capsaicin; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Pain; Palliative Care; Sensation Disorders

1996
Independent effects of ischaemia and noradrenaline on thermal hyperalgesia in capsaicin-treated skin.
    Pain, 1996, Volume: 67, Issue:1

    Topics: Adult; Capsaicin; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Ischemia; Male; Norepinephrine; Pain Threshold; Skin

1996
The sympathetic nervous system contributes to capsaicin-evoked mechanical allodynia but not pinprick hyperalgesia in humans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Nov-15, Volume: 16, Issue:22

    Topics: Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Pain; Phentolamine; Placebos; Sympathetic Nervous System; Sympatholytics; Touch

1996
Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin.
    Pain, 1996, Volume: 68, Issue:2-3

    Topics: Analysis of Variance; Capsaicin; Hair; Hot Temperature; Humans; Hyperalgesia; Injections, Subcutaneous; Pain Threshold; Psychophysics; Skin; Stress, Mechanical

1996
Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia.
    Anesthesiology, 1997, Volume: 86, Issue:6

    Topics: Adolescent; Adult; Anesthetics, Local; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Infusion Pumps; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Pain Measurement; Pain Threshold; Placebos; Sensory Thresholds; Skin Temperature

1997
Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans.
    Anesthesiology, 1997, Volume: 86, Issue:6

    Topics: Adult; Alfentanil; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Capsaicin; Drug Interactions; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Reproducibility of Results

1997
Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis.
    Pain, 1997, Volume: 71, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hyperalgesia; Ibuprofen; Male; Nociceptors; Pain Measurement; Pain Threshold; Skin Temperature

1997
A model of transient hyperalgesia in the behaving monkey induced by topical application of capsaicin.
    Pain, 1997, Volume: 72, Issue:1-2

    Topics: Acute Disease; Administration, Cutaneous; Adult; Analysis of Variance; Animals; Capsaicin; Conditioning, Operant; Escape Reaction; Hot Temperature; Humans; Hyperalgesia; Macaca mulatta; Male; Middle Aged; Photic Stimulation; Stress, Mechanical

1997
Correlation between local vascular and sensory changes following tissue inflammation induced by repetitive application of topical capsaicin.
    Brain research, 1998, May-04, Volume: 792, Issue:1

    Topics: Administration, Topical; Adult; Capsaicin; Dermatitis, Contact; Humans; Hyperalgesia; Male; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Skin Temperature

1998
Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:6

    Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Capsaicin; Cognition; Cross-Over Studies; Double-Blind Method; Drug Combinations; Excitatory Amino Acid Antagonists; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intradermal; Irritants; Ketamine; Male; Pain; Psychomotor Performance; Treatment Outcome

1998
Capsaicin-induced impairment of tactile spatial discrimination ability in man: indirect evidence for increased receptive fields in human nervous system.
    Brain research, 1998, Jun-29, Volume: 797, Issue:2

    Topics: Adult; Capsaicin; Discrimination Learning; Humans; Hyperalgesia; Male; Pain; Sensory Thresholds; Somatosensory Cortex; Touch; Vibration

1998
The human capsaicin model of allodynia and hyperalgesia: sources of variability and methods for reduction.
    Journal of pain and symptom management, 1998, Volume: 16, Issue:1

    Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Pain Measurement

1998
Intrathecal, but not intravenous, clonidine reduces experimental thermal or capsaicin-induced pain and hyperalgesia in normal volunteers.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Blood Pressure; Capsaicin; Clonidine; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Injections, Intravenous; Injections, Spinal; Male; Pain

1998
AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans.
    Anesthesiology, 1998, Volume: 89, Issue:5

    Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Isoquinolines; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Receptors, AMPA; Receptors, Kainic Acid; Skin; Tetrazoles

1998
Flare and hyperalgesia after intradermal capsaicin injection in human skin.
    Journal of neurophysiology, 1998, Volume: 80, Issue:6

    Topics: Adult; Anesthetics, Local; Capsaicin; Color; Dermatitis, Irritant; Female; Heart; Humans; Hyperalgesia; Hyperemia; Injections, Intradermal; Male; Middle Aged; Pain Threshold; Physical Stimulation; Skin Temperature

1998
Nitroprusside inhibits thermal hyperalgesia induced by noradrenaline in capsaicin-treated skin.
    Pain, 1999, Volume: 80, Issue:1-2

    Topics: Adolescent; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Middle Aged; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Pain Threshold; Regional Blood Flow; Skin; Vasoconstrictor Agents; Vasodilator Agents

1999
Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia.
    Acta dermato-venereologica, 1999, Volume: 79, Issue:2

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesia; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Pain Threshold; Paresthesia; Premedication; Prilocaine; Reference Values; Severity of Illness Index; Single-Blind Method; Treatment Outcome

1999
Sensory threshold changes without initial pain or alterations in cutaneous blood flow, in the area of secondary hyperalgesia caused by topical application of capsaicin in humans.
    Neuroscience letters, 1999, Apr-30, Volume: 266, Issue:1

    Topics: Administration, Topical; Adult; Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Nerve Fibers; Pain; Physical Stimulation; Regional Blood Flow; Sensory Thresholds; Skin; Vibration

1999
A new human experimental pain model: the heat/capsaicin sensitization model.
    Neuroreport, 1999, May-14, Volume: 10, Issue:7

    Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Pain; Reference Values

1999
The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:6

    Topics: Adult; Analgesics; Analgesics, Opioid; Axons; Capsaicin; Erythema; Female; Fentanyl; Humans; Hyperalgesia; Injections, Intradermal; Ketamine; Male; Middle Aged; Nociceptors; Reflex

1999
Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia.
    Pain, 2000, Volume: 84, Issue:1

    Topics: Adult; Analgesics; Blood Pressure; Capsaicin; Clonidine; Dose-Response Relationship, Drug; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Male; Pain

2000
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.
    Somatosensory & motor research, 1999, Volume: 16, Issue:4

    Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Paresthesia; Physical Stimulation; Pruritus; Skin; Skin Physiological Phenomena; Skin Tests; Time Factors

1999
Secondary hyperalgesia persists in capsaicin desensitized skin.
    Pain, 2000, Volume: 84, Issue:2-3

    Topics: Administration, Topical; Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Nociceptors; Pain Threshold; Physical Stimulation; Skin

2000
Age-related differences in the time course of capsaicin-induced hyperalgesia.
    Pain, 2000, Volume: 85, Issue:1-2

    Topics: Administration, Topical; Adult; Aged; Aging; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Time Factors

2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action.
    Pain, 2000, Volume: 85, Issue:1-2

    Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Intravenous; Laser-Doppler Flowmetry; Lidocaine; Male; Middle Aged; Pain Measurement

2000
Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans.
    British journal of anaesthesia, 2000, Volume: 84, Issue:2

    Topics: Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Ketamine; Lidocaine; Male; Pain Measurement; Pain Threshold; Touch

2000
Spatial mapping of the zone of secondary hyperalgesia reveals a gradual decline of pain with distance but sharp borders.
    Pain, 2000, Volume: 86, Issue:1-2

    Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Injections, Subcutaneous; Male; Middle Aged; Pain Measurement; Physical Stimulation; Reference Values

2000
The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adult; Anesthetics, Local; Capsaicin; Cross-Over Studies; Dizziness; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Male; Nociceptors; Pain; Pain Measurement; Pain Threshold; Placebos; Skin; Sleep Stages; Vision Disorders; Xerostomia

2000
Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans.
    British journal of anaesthesia, 2000, Volume: 85, Issue:4

    Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Lidocaine; Male; Pain Measurement; Touch

2000
Effect of remifentanil on pain and secondary hyperalgesia associated with the heat--capsaicin sensitization model in healthy volunteers.
    Anesthesiology, 2001, Volume: 94, Issue:1

    Topics: Adult; Analgesics, Opioid; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Piperidines; Remifentanil

2001
The effect of sympathetic activity on thermal hyperalgesia in capsaicin-treated skin during body cooling and warming.
    European journal of pain (London, England), 2001, Volume: 5, Issue:1

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Capsaicin; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Phenoxybenzamine; Receptors, Adrenergic, alpha; Skin; Sympathetic Nervous System

2001
Differential time courses of skin blood flow and hyperalgesia in the human sunburn reaction following ultraviolet irradiation of the skin.
    European journal of pain (London, England), 2001, Volume: 5, Issue:2

    Topics: Adult; Capsaicin; Dose-Response Relationship, Radiation; Erythema; Female; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Middle Aged; Pain Threshold; Regional Blood Flow; Skin; Sunburn; Ultraviolet Rays

2001
Repeated local administration of noradrenaline or saline inhibits thermal hyperalgesia in pain-sensitized human skin.
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Capsaicin; Female; Humans; Hyperalgesia; Male; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Regional Blood Flow; Skin; Sodium Chloride; Vasoconstrictor Agents

2001
Characterization of secondary hyperalgesia produced by topical capsaicin jelly--a new experimental tool for pain research.
    European journal of pain (London, England), 2001, Volume: 5, Issue:4

    Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Female; Gels; Humans; Hyperalgesia; Male; Nociceptors; Pain; Reproducibility of Results

2001
Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
    Anesthesiology, 2002, Volume: 96, Issue:1

    Topics: Adenosine; Adult; Analgesics; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Spinal; Male; Middle Aged; Pain; Pain Threshold

2002
The effect of heat conditioning of the primary area before and after induction of hyperalgesia by topical/intradermal capsaicin or by controlled heat injury.
    Somatosensory & motor research, 2001, Volume: 18, Issue:4

    Topics: Administration, Topical; Adult; Burns; Capsaicin; Conditioning, Psychological; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Skin Temperature

2001
Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia.
    Journal of clinical pharmacology, 2002, Volume: 42, Issue:1

    Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Middle Aged; Pain Threshold; Touch

2002

Other Studies

570 other study(ies) available for capsaicin and Allodynia

ArticleYear
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
    Journal of medicinal chemistry, 2020, 01-09, Volume: 63, Issue:1

    Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetulus; Drug Discovery; Hyperalgesia; Mice, Inbred ICR; Neuralgia; Phenylurea Compounds; Swine; Thiazoles; TRPV Cation Channels

2020
Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Analgesics; Animals; Anoctamin-1; Carboxylic Acids; HEK293 Cells; Humans; Hyperalgesia; Mice; Neoplasm Proteins; Pain

2022
Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans.
    Scientific reports, 2021, 10-21, Volume: 11, Issue:1

    Topics: Adult; Capsaicin; Central Nervous System Sensitization; Double-Blind Method; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Sensory System Agents; Young Adult

2021
Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
    International journal of molecular sciences, 2021, Oct-16, Volume: 22, Issue:20

    Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred ICR; Pain; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; TRPV Cation Channels

2021
How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021, Volume: 132, Issue:12

    Topics: Adult; Capsaicin; Central Nervous System Sensitization; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Models, Theoretical; Nociception; Pain Threshold; Physical Stimulation; Reflex; Sensory System Agents; Sural Nerve

2021
Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain.
    Pain, 2022, 08-01, Volume: 163, Issue:8

    Topics: Animals; Capsaicin; Chronic Pain; Hyperalgesia; Mice; Microtubules; Neuralgia; Paclitaxel; Trigeminal Neuralgia; TRPV Cation Channels; Tubulin

2022
The industrial solvent 1,4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1.
    BMC biology, 2022, 01-07, Volume: 20, Issue:1

    Topics: Animals; Capsaicin; Dioxanes; Hyperalgesia; Mice; Solvents; TRPV Cation Channels

2022
Priming of central and peripheral mechanisms with heat and cutaneous capsaicin facilitates secondary hyperalgesia to high-frequency electrical stimulation.
    Journal of neurophysiology, 2022, 03-01, Volume: 127, Issue:3

    Topics: Capsaicin; Electric Stimulation; Hot Temperature; Humans; Hyperalgesia; Pain; Pain Threshold

2022
Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 activation, and CGRP release.
    Neuropharmacology, 2022, 09-15, Volume: 216

    Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Docosahexaenoic Acids; Hyperalgesia; Lipopolysaccharides; Mice; Monocytes; Neurons; Neutrophils; Nociceptors; Pain; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2022
Age-related changes in peripheral nociceptor function.
    Neuropharmacology, 2022, 09-15, Volume: 216

    Topics: Aged; Analgesics, Opioid; Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Hyperalgesia; Nociceptors; Pain; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensory Receptor Cells

2022
Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1.
    European journal of pain (London, England), 2022, Volume: 26, Issue:9

    Topics: Animals; Calcium; Capsaicin; Chronic Pain; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Mice; Phosphorylation; Protein Kinase C; src-Family Kinases; TRPV Cation Channels

2022
Cell type-specific calcium imaging of central sensitization in mouse dorsal horn.
    Nature communications, 2022, 09-03, Volume: 13, Issue:1

    Topics: Animals; Calcium; Capsaicin; Central Nervous System Sensitization; Hyperalgesia; Mice; Posterior Horn Cells; Spinal Cord Dorsal Horn

2022
Small Synthetic Hyaluronan Disaccharide BIS014 Mitigates Neuropathic Pain in Mice.
    The journal of pain, 2023, Volume: 24, Issue:1

    Topics: Animals; Capsaicin; Gabapentin; Hyaluronic Acid; Hyperalgesia; Mice; Neuralgia; TRPV Cation Channels

2023
Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia.
    Neurophysiologie clinique = Clinical neurophysiology, 2022, Volume: 52, Issue:6

    Topics: Arousal; Capsaicin; Humans; Hyperalgesia; Pain; Pain Measurement; Skin

2022
Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain.
    International journal of molecular sciences, 2022, Dec-13, Volume: 23, Issue:24

    Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Diosgenin; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Mice; Neuralgia; TRPV Cation Channels

2022
Machine learning analysis predicts a person's sex based on mechanical but not thermal pain thresholds.
    Scientific reports, 2023, 05-05, Volume: 13, Issue:1

    Topics: Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Machine Learning; Male; Pain; Pain Measurement; Pain Threshold

2023
Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats.
    Investigative ophthalmology & visual science, 2023, 05-01, Volume: 64, Issue:5

    Topics: Animals; Capsaicin; Chronic Pain; Dry Eye Syndromes; Eye Pain; Female; Hyperalgesia; Neuralgia; Rats; Rats, Sprague-Dawley; Tears

2023
Effects of conditioned pain modulation on Capsaicin-induced spreading muscle hyperalgesia in humans.
    Scandinavian journal of pain, 2023, 10-26, Volume: 23, Issue:4

    Topics: Capsaicin; Humans; Hyperalgesia; Male; Myalgia; Pain Measurement; Rotator Cuff

2023
Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin.
    The European journal of neuroscience, 2023, Volume: 58, Issue:7

    Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Chronic Pain; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Inflammation; Methoxsalen; Mice

2023
Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons.
    Cell reports, 2019, 08-06, Volume: 28, Issue:6

    Topics: Animals; Calbindin 2; Capsaicin; Hyperalgesia; Interneurons; Male; Memory; Mice, Inbred C57BL; Neural Pathways; Nociception; Optogenetics; Parabrachial Nucleus; Posterior Horn Cells; Recruitment, Neurophysiological; Spinal Cord Dorsal Horn

2019
Age and Sex Differences in Acute and Osteoarthritis-Like Pain Responses in Rats.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 07-13, Volume: 75, Issue:8

    Topics: Aging; Animals; Arthritis, Experimental; Behavior, Animal; Capsaicin; Enzyme Inhibitors; Female; Hyperalgesia; Iodoacetic Acid; Male; Pain Measurement; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats, Inbred F344; Sex Factors; Spinal Cord; Weight-Bearing

2020
The opposing contribution of neurotrophin-3 and nerve growth factor to orofacial heat hyperalgesia in rats.
    Behavioural pharmacology, 2020, Volume: 31, Issue:1

    Topics: Animals; Capsaicin; Facial Pain; Hot Temperature; Hyperalgesia; Male; Nerve Growth Factor; Neurotrophin 3; Rats; Rats, Wistar; Receptor, trkA; Trigeminal Neuralgia

2020
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
    Neuropharmacology, 2020, Volume: 163

    Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins

2020
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
    Behavioural pharmacology, 2020, Volume: 31, Issue:2&3

    Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Nociception; Nucleus Accumbens; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Stress, Psychological

2020
Abnormal Pain Sensation in Mice Lacking the Prokineticin Receptor PKR2: Interaction of PKR2 with Transient Receptor Potential TRPV1 and TRPA1.
    Neuroscience, 2020, 02-10, Volume: 427

    Topics: Amphibian Proteins; Animals; Capsaicin; Ganglia, Spinal; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Neuropeptides; Nociception; Pain; Plant Oils; Receptors, G-Protein-Coupled; TRPA1 Cation Channel; TRPV Cation Channels

2020
Experimenter- and Infrared Thermography-Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults.
    Pain medicine (Malden, Mass.), 2020, 10-01, Volume: 21, Issue:10

    Topics: Adult; Black or African American; Capsaicin; Ethnicity; Humans; Hyperalgesia; Minority Groups; Thermography

2020
Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice.
    Journal of pharmacological sciences, 2020, Volume: 143, Issue:1

    Topics: Animals; Calcineurin Inhibitors; Capsaicin; Colon; Hyperalgesia; Immunosuppressive Agents; Irritable Bowel Syndrome; Mice; Tacrolimus; TRPV Cation Channels

2020
Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats.
    European journal of pain (London, England), 2020, Volume: 24, Issue:6

    Topics: Animals; Capsaicin; Denervation; Humans; Hyperalgesia; Microscopy, Confocal; Pain, Postoperative; Rats

2020
Thiopental Does Not Produce Hyperalgesia: A Laboratory Study Using Two Human Experimental Pain Models.
    Pain medicine (Malden, Mass.), 2020, 11-01, Volume: 21, Issue:11

    Topics: Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Laboratories; Pain; Thiopental

2020
Capsaicin-Induced Changes in Electrical Pain Perception Threshold Can Be Used to Assess the Magnitude of Secondary Hyperalgesia in Humans.
    Pain medicine (Malden, Mass.), 2020, 11-01, Volume: 21, Issue:11

    Topics: Capsaicin; Hot Temperature; Humans; Hyperalgesia; Pain; Pain Perception; Pain Threshold

2020
Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats.
    Pharmacological reports : PR, 2020, Volume: 72, Issue:3

    Topics: Analgesics; Animals; Calcium Channels, N-Type; Capsaicin; Disease Models, Animal; Facial Pain; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Neuralgia; omega-Conotoxins; Pain Measurement; Rats; Rats, Wistar; TRPA1 Cation Channel

2020
The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin.
    Neuroreport, 2020, 08-05, Volume: 31, Issue:11

    Topics: Animals; Bradykinin; Capsaicin; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Nociception; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sensory System Agents; TRPV Cation Channels

2020
Modality-specific facilitation of noninjurious sharp mechanical pain by topical capsaicin.
    Pain, 2021, Volume: 162, Issue:1

    Topics: Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold

2021
Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues.
    International journal of molecular sciences, 2020, Aug-10, Volume: 21, Issue:16

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anesthesia, Local; Anesthetics, Local; Animals; Calorimetry, Differential Scanning; Capsaicin; Carrageenan; Disease Models, Animal; Drug Compounding; Drug Stability; Drug Therapy, Combination; Excipients; Hyperalgesia; Inflammation; Magnetic Resonance Spectroscopy; Male; Mepivacaine; Mice; Microscopy, Electron, Scanning; Pain; Pain Management; Solubility; X-Ray Diffraction

2020
Pain-autonomic interaction: A surrogate marker of central sensitization.
    European journal of pain (London, England), 2020, Volume: 24, Issue:10

    Topics: Biomarkers; Capsaicin; Central Nervous System Sensitization; Humans; Hyperalgesia; Pain; Pain Measurement

2020
Antiallodynic effect of PhAR-DBH-Me involves cannabinoid and TRPV1 receptors.
    Pharmacology research & perspectives, 2020, Volume: 8, Issue:5

    Topics: Animals; Antineoplastic Agents; Arachidonic Acids; Azabicyclo Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Cisplatin; Endocannabinoids; Female; Hyperalgesia; Injections, Intraperitoneal; Ligation; Models, Animal; Neuralgia; Oleic Acids; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spinal Nerves; TRPV Cation Channels; Vagus Nerve Stimulation

2020
Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract.
    Journal of ethnopharmacology, 2021, Apr-06, Volume: 269

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capsaicin; Castor Oil; Colitis, Ulcerative; Colon; Diarrhea; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Hyperalgesia; Inflammation; Lamiaceae; Male; Mice; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Visceral Pain

2021
CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache.
    Cephalalgia : an international journal of headache, 2021, Volume: 41, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Brain Concussion; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Pain; Diffuse Noxious Inhibitory Control; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Post-Traumatic Headache

2021
Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy.
    Neural plasticity, 2021, Volume: 2021

    Topics: Animals; Astrocytes; Capsaicin; Diterpenes; Ganglia, Spinal; Hyperalgesia; Intercellular Signaling Peptides and Proteins; Male; Neuralgia; Neurons; Rats, Sprague-Dawley; Spinal Cord

2021
Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:4

    Topics: Animals; Biomarkers; Capsaicin; Carrageenan; Endocannabinoids; Flurbiprofen; Gene Expression Regulation; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Pain

2021
Sex-dependent Cav2.3 channel contribution to the secondary hyperalgesia in a mice model of central sensitization.
    Brain research, 2021, 08-01, Volume: 1764

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, R-Type; Capsaicin; Cation Transport Proteins; Central Nervous System Sensitization; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Gene Knockdown Techniques; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Oligonucleotides, Antisense; Sex Characteristics; Spider Venoms; Spinal Cord

2021
Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model.
    Pharmacological reports : PR, 2021, Volume: 73, Issue:3

    Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Spinal Cord; TRPV Cation Channels

2021
During capsaicin-induced central sensitization, brush allodynia is associated with baseline warmth sensitivity, whereas mechanical hyperalgesia is associated with painful mechanical sensibility, anxiety and somatization.
    European journal of pain (London, England), 2021, Volume: 25, Issue:9

    Topics: Anxiety; Capsaicin; Central Nervous System Sensitization; Humans; Hyperalgesia; Male; Neuralgia; Pain Threshold; Reproducibility of Results

2021
Postinjury stimulation triggers a transition to nociplastic pain in mice.
    Pain, 2022, 03-01, Volume: 163, Issue:3

    Topics: Animals; Capsaicin; Chronic Pain; Female; Humans; Hyperalgesia; Male; Mice; Morphine; Pain Measurement

2022
A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain.
    Neuropharmacology, 2017, 05-15, Volume: 118

    Topics: Animals; Botulinum Toxins; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Male; Models, Molecular; Motor Activity; Neuralgia; Peptide Hydrolases; Pregabalin; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Sensory Receptor Cells; Synaptosomal-Associated Protein 25; Time Factors; Trigeminal Ganglion

2017
Differential effect of Incobotulinumtoxin A on pain, neurogenic flare and hyperalgesia in human surrogate models of neurogenic pain.
    European journal of pain (London, England), 2017, Volume: 21, Issue:8

    Topics: Adult; Botulinum Toxins, Type A; Capsaicin; Electric Stimulation; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Nerve Fibers, Unmyelinated; Neuralgia; Neuromuscular Agents; Pain Measurement; Pain Threshold; Sensory System Agents; Young Adult

2017
Chronic stress-induced mechanical hyperalgesia is controlled by capsaicin-sensitive neurones in the mouse.
    European journal of pain (London, England), 2017, Volume: 21, Issue:8

    Topics: Animals; Capsaicin; Cold Temperature; Disease Models, Animal; Diterpenes; Hot Temperature; Hyperalgesia; Male; Mice; Nociception; Nociceptive Pain; Nociceptors; Restraint, Physical; Stress, Psychological

2017
Role of peripheral and central TRPV1 receptors in facial heat hyperalgesia in streptozotocin-induced diabetic rats.
    Brain research, 2017, Sep-01, Volume: 1670

    Topics: Animals; Capsaicin; Diabetes Mellitus, Experimental; Diterpenes; Face; Facial Pain; Hot Temperature; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Trigeminal Ganglion; TRPV Cation Channels

2017
Effects of Tetrodotoxin in Mouse Models of Visceral Pain.
    Marine drugs, 2017, Jun-21, Volume: 15, Issue:6

    Topics: Analgesics; Animals; Capsaicin; Colon; Cystitis; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Knockout; Morphine; Mustard Plant; Nociceptors; Pain Measurement; Plant Oils; Sodium Channels; Tetrodotoxin; Visceral Pain

2017
D-limonene exhibits superior antihyperalgesic effects in a β-cyclodextrin-complexed form in chronic musculoskeletal pain reducing Fos protein expression on spinal cord in mice.
    Neuroscience, 2017, 09-01, Volume: 358

    Topics: Analgesics; Animals; beta-Cyclodextrins; Capsaicin; Cyclohexenes; Disease Models, Animal; Drug Combinations; Drug Interactions; GABA Agents; Hyperalgesia; Limonene; Male; Mice; Muscle Strength; Musculoskeletal Pain; Nociception; Pain Measurement; Pain Threshold; Proto-Oncogene Proteins c-fos; Spinal Cord; Statistics, Nonparametric; Terpenes

2017
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis.
    Pain, 2018, Volume: 159, Issue:1

    Topics: Adult; Capsaicin; Female; Healthy Volunteers; Humans; Hyperalgesia; Machine Learning; Male; Pain Measurement; Pain Threshold; Skin; Ultraviolet Rays; Young Adult

2018
Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla.
    Journal of neurophysiology, 2017, 11-01, Volume: 118, Issue:5

    Topics: Animals; Capsaicin; Catheters, Indwelling; Central Nervous System Sensitization; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Microelectrodes; Neurokinin-1 Receptor Antagonists; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Touch

2017
Low-threshold mechanoreceptors play a frequency-dependent dual role in subjective ratings of mechanical allodynia.
    Journal of neurophysiology, 2017, 12-01, Volume: 118, Issue:6

    Topics: Adult; Brain; Brain Mapping; Capsaicin; Female; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Mechanoreceptors; Neurons, Afferent; Pain Perception; Physical Stimulation

2017
Characterization of a novel capsaicin/heat ongoing pain model.
    European journal of pain (London, England), 2018, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Capsaicin; Female; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Sensation; Skin; Young Adult

2018
Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross-Sectional Study.
    Headache, 2018, Volume: 58, Issue:1

    Topics: Adolescent; Capsaicin; Cross-Sectional Studies; Female; Humans; Hyperalgesia; Male; Migraine Disorders; Oxytocin; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Sensory System Agents; Statistics, Nonparametric; Surveys and Questionnaires; Time Factors; Young Adult

2018
Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Disease Models, Animal; Hyperalgesia; Ketorolac; Male; Piroxicam; Rats; Rats, Wistar; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2018
Cerebral peak alpha frequency predicts individual differences in pain sensitivity.
    NeuroImage, 2018, 02-15, Volume: 167

    Topics: Adult; Alpha Rhythm; Biomarkers; Capsaicin; Central Nervous System Sensitization; Electroencephalography; Female; Humans; Hyperalgesia; Individuality; Male; Pain Measurement; Pain Perception; Pain Threshold; Sensorimotor Cortex; Sensory System Agents; Young Adult

2018
Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents.
    Biological & pharmaceutical bulletin, 2018, Feb-01, Volume: 41, Issue:2

    Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Drug Resistance; Facial Nerve Diseases; Hindlimb; Hot Temperature; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Migraine Disorders; Nerve Tissue Proteins; Neurons, Afferent; Neurotoxins; Nitric Oxide Donors; Nitroglycerin; Organ Specificity; Peripheral Nervous System Diseases; Sensory System Agents; TRPV Cation Channels

2018
A novel human pain insensitivity disorder caused by a point mutation in ZFHX2.
    Brain : a journal of neurology, 2018, 02-01, Volume: 141, Issue:2

    Topics: Action Potentials; Adolescent; Adult; Aged; Animals; Calcium; Capsaicin; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Pain; Pain Insensitivity, Congenital; Pain Threshold; Point Mutation; Sensory Receptor Cells; Skin; Young Adult; Zinc Finger E-box Binding Homeobox 2

2018
Physiological and pathological characterization of capsaicin-induced reversible nerve degeneration and hyperalgesia.
    European journal of pain (London, England), 2018, Volume: 22, Issue:6

    Topics: Adult; Capsaicin; Evoked Potentials; Female; Humans; Hyperalgesia; Male; Nerve Degeneration; Nerve Fibers; Pain Threshold; Skin; Young Adult

2018
Supraspinal modulation of neuronal synchronization by nociceptive stimulation induces an enduring reorganization of dorsal horn neuronal connectivity.
    The Journal of physiology, 2018, 05-01, Volume: 596, Issue:9

    Topics: Anesthetics, Local; Animals; Capsaicin; Cats; Female; Hyperalgesia; Lidocaine; Male; Nerve Net; Nociception; Physical Stimulation; Posterior Horn Cells; Sensory System Agents

2018
Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models.
    Pain, 2018, Volume: 159, Issue:6

    Topics: Adult; Aged; Algorithms; Capsaicin; Female; Healthy Volunteers; Humans; Hyperalgesia; Lidocaine; Male; Middle Aged; Models, Biological; Nerve Block; Neuralgia; Pain Measurement; Pain Perception; Pain Threshold; Phenotype; Sensation; Sensory System Agents; Young Adult

2018
Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis.
    Biochemical and biophysical research communications, 2018, 06-02, Volume: 500, Issue:2

    Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Ethylnitrosourea; Ganglia, Spinal; Hyperalgesia; Ligation; Loss of Function Mutation; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Neurons; Phenotype; Potassium; Spinal Nerves; TRPV Cation Channels

2018
Antinociception by the anti-oxidized phospholipid antibody E06.
    British journal of pharmacology, 2018, Volume: 175, Issue:14

    Topics: Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Autoantibodies; Capsaicin; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Irritants; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidation-Reduction; Pain; Phosphatidylcholines; Rats, Wistar; TRPA1 Cation Channel; TRPV Cation Channels

2018
TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain.
    Scientific reports, 2018, 05-08, Volume: 8, Issue:1

    Topics: Animals; Capsaicin; Chemokine CCL2; Chronic Pain; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pelvic Pain; Receptors, CCR2; Signal Transduction; Toll-Like Receptor 4; TRPV Cation Channels; Urinary Tract Infections; Uropathogenic Escherichia coli

2018
Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors.
    Pain, 2018, Volume: 159, Issue:11

    Topics: Acrylamides; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Binding Proteins; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fish Venoms; Ganglia, Spinal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Hyperalgesia; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurogenic Inflammation; Oncogene Proteins v-fos; Pain; Pain Measurement; Sensory Receptor Cells; Time Factors; Touch; TRPV Cation Channels

2018
New
    Scientific reports, 2018, 07-03, Volume: 8, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin

2018
Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia.
    Pain, 2018, Volume: 159, Issue:11

    Topics: Acetylcysteine; Action Potentials; Animals; Biotinylation; Capsaicin; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Erythromycin; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Neurons; Patch-Clamp Techniques; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X4; Signal Transduction; TRPV Cation Channels

2018
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; Ganglia, Spinal; Hyperalgesia; Lysergic Acid Diethylamide; Male; Maze Learning; Neuralgia; Piperazines; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Swimming

2019
Pain chronification and chronic pain impair a defensive behavior, but not the ability of acute pain to facilitate it, through the activation of an endogenous analgesia circuit.
    Behavioral neuroscience, 2018, Volume: 132, Issue:6

    Topics: Acute Pain; Animals; Capsaicin; Chronic Pain; Freezing Reaction, Cataleptic; Hydroxy Acids; Hyperalgesia; Male; Neural Pathways; Nociceptive Pain; Nucleus Accumbens; Oleic Acids; Pain Perception; Random Allocation; Rats, Wistar; Receptors, Opioid, mu

2018
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
    Science translational medicine, 2018, 10-10, Volume: 10, Issue:462

    Topics: Action Potentials; Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Ion Channels; Mechanotransduction, Cellular; Mice, Knockout; Neurons; Nociception; Nociceptors; Pain

2018
Vti1b promotes TRPV1 sensitization during inflammatory pain.
    Pain, 2019, Volume: 160, Issue:2

    Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Humans; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pain; Qb-SNARE Proteins; RNA Interference; Sensory Receptor Cells; Signal Transduction; TRPV Cation Channels

2019
Sex differences in measures of central sensitization and pain sensitivity to experimental sleep disruption: implications for sex differences in chronic pain.
    Sleep, 2019, 02-01, Volume: 42, Issue:2

    Topics: Adult; Antipruritics; Attention; Capsaicin; Central Nervous System Sensitization; Chronic Pain; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Polysomnography; Sex Characteristics; Sleep; Sleep Deprivation

2019
Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse.
    Scientific reports, 2018, 10-29, Volume: 8, Issue:1

    Topics: Animals; Ankle Joint; Antibodies; Arthritis, Experimental; Body Weight; Capsaicin; Disease Models, Animal; Diterpenes; Edema; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Severity of Illness Index; X-Ray Microtomography

2018
Dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation.
    Pain, 2019, Volume: 160, Issue:2

    Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Benzalkonium Compounds; Capsaicin; Cornea; Corneal Injuries; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Propionates; Sensory System Agents; Trigeminal Ganglion

2019
Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy.
    Neuropharmacology, 2019, 03-01, Volume: 146

    Topics: Animals; Capsaicin; Excitatory Postsynaptic Potentials; Hyperalgesia; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oncogene Protein v-akt; Paclitaxel; Peptide Fragments; Phosphatidylinositol 3-Kinases; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Spinal Cord; Toll-Like Receptor 4; Transient Receptor Potential Channels; TRPV Cation Channels

2019
Capsaicin-induced pain and sensitisation in the postpartum period.
    British journal of anaesthesia, 2019, Volume: 122, Issue:1

    Topics: Adolescent; Adult; Animals; Capsaicin; Case-Control Studies; Cesarean Section; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Postoperative Period; Postpartum Period; Pregnancy; Rats, Sprague-Dawley; Stress, Psychological; Young Adult

2019
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
    BMC neuroscience, 2019, Jan-03, Volume: 20, Issue:1

    Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cystathionine beta-Synthase; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hydrogen Sulfide; Hydroxylamine; Hyperalgesia; Imidazoles; Nociception; Purines; Rats, Wistar; Skin; Spinal Nerve Roots; Sulfites; Transient Receptor Potential Channels

2019
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:5

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Lidocaine; Male; Pain; Rats, Wistar

2019
Differential activation of ascending noxious pathways associated with trigeminal nerve injury.
    Pain, 2019, Volume: 160, Issue:6

    Topics: Animals; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Facial Pain; Hyperalgesia; Male; Nociceptors; Parabrachial Nucleus; Rats, Sprague-Dawley; Spinal Cord; Trigeminal Nerve Injuries

2019
Transcription factor Sp4 is required for hyperalgesic state persistence.
    PloS one, 2019, Volume: 14, Issue:2

    Topics: Animals; Calcium; Capsaicin; Cold Temperature; Down-Regulation; Ganglia, Spinal; Heterozygote; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Growth Factor; Nociceptors; Oxaliplatin; Sp4 Transcription Factor; Stress, Mechanical; TRPV Cation Channels

2019
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.
    Neurological research, 2019, Volume: 41, Issue:6

    Topics: Acid Sensing Ion Channels; Animals; Capsaicin; Diabetes Mellitus, Experimental; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Mirtazapine; Rats; Streptozocin; TRPV Cation Channels

2019
Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study.
    Acta dermato-venereologica, 2019, Jun-01, Volume: 99, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antipruritics; Capsaicin; Case-Control Studies; Chronic Disease; Female; Histamine; Histamine Agonists; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Peripheral Nerves; Physical Stimulation; Pruritus; Reaction Time; Skin; TRPV Cation Channels

2019
Cutaneous nociceptive sensitization affects the directional discrimination - but not the 2-point discrimination.
    Scandinavian journal of pain, 2019, 07-26, Volume: 19, Issue:3

    Topics: Administration, Cutaneous; Adult; Antipruritics; Capsaicin; Discrimination, Psychological; Female; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Touch

2019
Antinociceptive activity of Copaifera officinalis Jacq. L oil and kaurenoic acid in mice.
    Inflammopharmacology, 2019, Volume: 27, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Diterpenes; Fabaceae; Female; Freund's Adjuvant; Hyperalgesia; Male; Mice; Nociception; Oils, Volatile; Pain Measurement; Plant Extracts

2019
Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain.
    Neuroscience bulletin, 2020, Volume: 36, Issue:1

    Topics: Animals; Capsaicin; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Irritants; Mentha piperita; Models, Animal; Mustard Plant; Myalgia; Neurons, Afferent; Nociceptive Pain; Nociceptors; Physical Stimulation; Plant Oils; Rats; Rats, Sprague-Dawley; Skin

2020
The Acute Effect of Skin Preheating on Capsaicin-Induced Central Sensitization in Humans.
    Pain practice : the official journal of World Institute of Pain, 2019, Volume: 19, Issue:8

    Topics: Adult; Capsaicin; Central Nervous System Sensitization; Cross-Over Studies; Female; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Skin; Young Adult

2019
Trigeminal Pain Responses in Obese ob/ob Mice Are Modality-Specific.
    Neuroscience, 2019, 09-01, Volume: 415

    Topics: Animals; Behavior; Capsaicin; Diet; Eating; Hyperalgesia; Leptin; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Models, Animal; Nociception; Obesity; Pain; Pain Measurement; Quinine; Trigeminal Ganglion; TRPV Cation Channels

2019
Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury.
    Neuropharmacology, 2019, 11-01, Volume: 158

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Calcium Channel Blockers; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Interneurons; Lidocaine; Male; Microscopy, Confocal; Neuropeptide Y; Nociception; omega-Conotoxins; Peripheral Nerve Injuries; Posterior Horn Cells; Potassium Chloride; Protein Transport; Protein Tyrosine Phosphatases; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide Y; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; TRPV Cation Channels; Voltage-Gated Sodium Channel Blockers

2019
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
    Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4

    Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular Structure; Olea; Pain; Pain Measurement; Pregabalin; Rotarod Performance Test; Time Factors; Triterpenes

2013
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
    European journal of pharmacology, 2013, May-15, Volume: 708, Issue:1-3

    Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarates; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Rats; Rats, Sprague-Dawley

2013
Capsaicin avoidance as a measure of chemical hyperalgesia in orofacial nerve injury models.
    Neuroscience letters, 2013, May-24, Volume: 543

    Topics: Animals; Avoidance Learning; Capsaicin; Constriction, Pathologic; Facial Pain; Hot Temperature; Hyperalgesia; Ligation; Lingual Nerve Injuries; Male; Neurons; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Touch; Trigeminal Nerve Injuries; Trigeminal Nuclei

2013
Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms.
    Stress (Amsterdam, Netherlands), 2013, Volume: 16, Issue:5

    Topics: Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Edema; Hindlimb; Hyperalgesia; Inflammation; Male; Naloxone; Nociception; Oxidopamine; Pain; Rats; Rats, Sprague-Dawley; Restraint, Physical; Sciatic Nerve; Stress, Psychological; Sympathetic Nervous System

2013
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
    The journal of pain, 2013, Volume: 14, Issue:6

    Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histamine; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofibromatosis 1; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Pain Threshold; Pruritus

2013
Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons.
    Phytotherapy research : PTR, 2014, Volume: 28, Issue:2

    Topics: Adenosine Triphosphate; Animals; Burns; Capsaicin; Cells, Cultured; Dermatitis; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neurons; Pain; Pinus; Plant Oils; Resins, Plant; Skin

2014
Healthy volunteers can be phenotyped using cutaneous sensitization pain models.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Antipruritics; Burns; Capsaicin; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Models, Biological; Pain; Pain Measurement; Reproducibility of Results; Skin

2013
Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, May-22, Volume: 33, Issue:21

    Topics: A Kinase Anchor Proteins; Animals; Bacterial Proteins; Binding Sites; Calcium; Capsaicin; Carrageenan; Cell Line, Transformed; Chlorocebus aethiops; Female; Ganglia, Spinal; Humans; Hyperalgesia; Immunoprecipitation; Luminescent Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mutation; Neurons; Pain Threshold; Patch-Clamp Techniques; Peptides; Transfection; TRPV Cation Channels

2013
Peripheral G protein-coupled inwardly rectifying potassium channels are involved in δ-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle.
    European journal of pain (London, England), 2014, Volume: 18, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Brain Stem; Capsaicin; Enkephalin, D-Penicillamine (2,5)-; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genes, fos; Hyperalgesia; Immunohistochemistry; Male; Masseter Muscle; Physical Stimulation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Opioid, delta; RNA, Messenger; Sensory System Agents; Trigeminal Ganglion

2014
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
    Journal of natural products, 2013, Jun-28, Volume: 76, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Benzoquinones; Capsaicin; Carrageenan; Cytokines; Disease Models, Animal; Freund's Adjuvant; Glycosides; Hyperalgesia; Inflammation; Male; Mice; Molecular Structure; Oxidative Stress; Pain; Plant Extracts; TRPV Cation Channels

2013
Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine.
    Molecular pain, 2013, Jun-14, Volume: 9

    Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Conditioning, Operant; Facial Nerve; Facial Pain; Hyperalgesia; Male; Menthol; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Trigeminal Nerve; Trigeminal Nerve Injuries; TRPM Cation Channels

2013
Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.
    Neuroscience, 2013, Sep-17, Volume: 248

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Capsaicin; Catalase; Deoxyguanosine; Fluorescent Dyes; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hyperalgesia; Immunohistochemistry; Mice; Mice, Transgenic; Neurons; Oxidative Stress; Promoter Regions, Genetic; Satellite Cells, Perineuronal; SOXE Transcription Factors; Thioredoxins; Trigeminal Ganglion; TRPV Cation Channels

2013
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia.
    Neuroscience, 2013, Oct-10, Volume: 250

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Catheterization; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Synaptic Transmission

2013
Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Acetone; Acrolein; Acrylamides; Acute Disease; Alkaloids; Analgesics; Animals; Aporphines; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Chronic Pain; Cold Temperature; Freund's Adjuvant; Gene Expression; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Transient Receptor Potential Channels; TRPA1 Cation Channel

2013
Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.
    Pflugers Archiv : European journal of physiology, 2014, Volume: 466, Issue:3

    Topics: Action Potentials; Animals; Calcium; Capsaicin; Cells, Cultured; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Isothiocyanates; Mice; Mice, Inbred C57BL; Sensory Receptor Cells; Thermosensing; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2014
Facilitation of pain in the human spinal cord by nocebo treatment.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Aug-21, Volume: 33, Issue:34

    Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Oxygen; Pain; Pain Measurement; Pain Perception; Pain Threshold; Spinal Cord; Surveys and Questionnaires; Time Factors; Young Adult

2013
Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice.
    Journal of ethnopharmacology, 2013, Nov-25, Volume: 150, Issue:2

    Topics: Acrolein; Analgesics; Animals; Asteraceae; Capsaicin; Ethanol; Flowers; Formaldehyde; Hot Temperature; Hyperalgesia; Ligation; Male; Mice; Pain; Phytotherapy; Plant Extracts; Sciatic Nerve; Solvents; Touch

2013
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
    Brain research, 2014, Jan-16, Volume: 1543

    Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Polymers; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Time Factors

2014
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
    Anesthesiology, 2014, Volume: 120, Issue:4

    Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Hyperalgesia; Hypersensitivity, Delayed; Lidocaine; Male; Nerve Block; Nerve Fibers; Neural Conduction; Neurotoxicity Syndromes; Nociceptors; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels

2014
Polypeptide modulators of TRPV1 produce analgesia without hyperthermia.
    Marine drugs, 2013, Dec-16, Volume: 11, Issue:12

    Topics: Analgesia; Analgesics; Animals; Body Temperature; Capsaicin; Cell Line; Disease Models, Animal; Fever; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Male; Mice; Pain; Peptides; TRPV Cation Channels

2013
Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain.
    Pain, 2014, Volume: 155, Issue:4

    Topics: Acute Pain; Analysis of Variance; Animals; Capsaicin; Cerebral Cortex; Chronic Pain; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Hyperalgesia; Male; Neural Pathways; Rats; Rats, Sprague-Dawley; Thalamus; Theta Rhythm; Time Factors

2014
TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia.
    Neuropharmacology, 2014, Volume: 81

    Topics: Anilides; Animals; Animals, Newborn; Capsaicin; Chemokine CCL2; Cinnamates; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Hyperalgesia; In Vitro Techniques; Male; MAP Kinase Kinase Kinase 3; Pain Threshold; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Wistar; Sensory System Agents; Spinal Cord; Time Factors; TRPV Cation Channels

2014
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
    Neuroscience, 2014, Apr-25, Volume: 266

    Topics: Action Potentials; Animals; Capsaicin; Disease Models, Animal; Electrophysiology; Hindlimb; Histamine; Hyperalgesia; Injections, Intradermal; Mice; Mice, Inbred C57BL; Pain; Posterior Horn Cells; Pruritus; Sensory System Agents; Spinal Cord

2014
Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia.
    Behavioural pharmacology, 2014, Volume: 25, Issue:2

    Topics: Animals; Capsaicin; Carrageenan; Cold Temperature; Disease Models, Animal; Diterpenes; Facial Pain; Formaldehyde; Hot Temperature; Hyperalgesia; Male; Neuralgia; Neurons; Nociception; Rats; Rats, Wistar; Sensory System Agents; Trigeminal Ganglion; TRPV Cation Channels

2014
Complex generalized instead of complex regional?
    Anesthesiology, 2014, Volume: 120, Issue:5

    Topics: Capsaicin; Complex Regional Pain Syndromes; Female; Hot Temperature; Humans; Hyperalgesia; Male

2014
Endothelin-1-induced priming to capsaicin in young animals.
    Neuroscience letters, 2014, May-01, Volume: 567

    Topics: Animals; Animals, Newborn; Capsaicin; Endothelin-1; Female; Functional Laterality; Hyperalgesia; Male; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Sex Factors; Touch

2014
Intradermal glutamate and capsaicin injections: intra- and interindividual variability of provoked hyperalgesia and allodynia.
    Clinical and experimental pharmacology & physiology, 2014, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Capsaicin; Glutamic Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation; Reproducibility of Results; Sensory System Agents; Touch; Young Adult

2014
Evidence for acute central sensitization to prolonged experimental pain in posttraumatic stress disorder.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:5

    Topics: Acute Pain; Adult; Anxiety; Capsaicin; Catastrophization; Central Nervous System Sensitization; Chronic Pain; Comorbidity; Depression; Evidence-Based Medicine; Humans; Hyperalgesia; Male; Pain Threshold; Pressure; Quality of Life; Sensory System Agents; Stress Disorders, Post-Traumatic; Surveys and Questionnaires; Young Adult

2014
Capsaicin-induced neurogenic inflammation in pig skin: a behavioural study.
    Research in veterinary science, 2014, Volume: 96, Issue:3

    Topics: Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Male; Neurogenic Inflammation; Random Allocation; Skin; Statistics, Nonparametric; Swine; Video Recording

2014
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2014
Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain.
    Molecular pain, 2014, May-21, Volume: 10

    Topics: Acid Sensing Ion Channels; Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Pain Measurement; Signal Transduction; Substance P; TRPV Cation Channels

2014
LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Administration, Oral; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Enzyme Activation; Female; Hydrogen-Ion Concentration; Hyperalgesia; Imidazoles; Inflammation; Macrophages, Peritoneal; MAP Kinase Signaling System; Mice, Inbred BALB C; Neuralgia; Neutrophil Infiltration; Oocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Time Factors; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Xenopus laevis

2014
A spinal analog of memory reconsolidation enables reversal of hyperalgesia.
    Nature neuroscience, 2014, Volume: 17, Issue:8

    Topics: Animals; Anisomycin; Capsaicin; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Male; Memory; Mice; Mice, Inbred C57BL; Pain; Posterior Horn Cells; Protein Synthesis Inhibitors; Sensory System Agents; Spinal Cord

2014
Spatio-temporal expression and functional involvement of transient receptor potential vanilloid 1 in diabetic mechanical allodynia in rats.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Analysis of Variance; Animals; Blotting, Western; Capsaicin; Diabetic Neuropathies; Fluorescent Antibody Technique; Ganglia, Spinal; Gene Expression Profiling; Gene Expression Regulation; Hyperalgesia; Image Processing, Computer-Assisted; Immunohistochemistry; Rats; Real-Time Polymerase Chain Reaction; Ruthenium Red; Spinal Cord; Streptozocin; Time Factors; TRPV Cation Channels

2014
β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons.
    Molecular pain, 2014, Aug-01, Volume: 10

    Topics: Animals; Arrestins; Benzamides; beta-Arrestin 2; beta-Arrestins; Capsaicin; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Lectins; Male; Mice; Mice, Inbred C57BL; Pain Threshold; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sensory Receptor Cells; Sensory System Agents; Species Specificity; Time Factors; Trigeminal Ganglion; TRPV Cation Channels

2014
Activation of transient receptor potential vanilloid 2-expressing primary afferents stimulates synaptic transmission in the deep dorsal horn of the rat spinal cord and elicits mechanical hyperalgesia.
    The European journal of neuroscience, 2014, Volume: 40, Issue:8

    Topics: Afferent Pathways; Animals; Capsaicin; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Male; Neurons; Nociception; Probenecid; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Synaptic Transmission; TRPV Cation Channels

2014
Assessment of intraoral mucosal pain induced by the application of capsaicin.
    Archives of oral biology, 2014, Volume: 59, Issue:12

    Topics: Animals; Capsaicin; Disease Models, Animal; Hyperalgesia; Male; Nociceptors; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Trigeminal Nerve Injuries

2014
Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways.
    Cancer letters, 2014, Dec-28, Volume: 355, Issue:2

    Topics: Animals; Capsaicin; Cell Line, Tumor; Cytokines; Drugs, Chinese Herbal; Female; Hyperalgesia; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Phosphorylation; Proto-Oncogene Proteins c-akt; Sarcoma; TRPV Cation Channels

2014
Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
    Journal of oral & facial pain and headache, 2014,Fall, Volume: 28, Issue:4

    Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Chronic Pain; Disease Models, Animal; Facial Neoplasms; Facial Pain; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Irritants; Lip Diseases; Male; Neoplasm Transplantation; Orbit; Pain Measurement; Pregabalin; Random Allocation; Rats, Wistar; Sensory System Agents; Trigeminal Neuralgia

2014
TRPA1 contributes to capsaicin-induced facial cold hyperalgesia in rats.
    European journal of oral sciences, 2014, Volume: 122, Issue:6

    Topics: Acetanilides; Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Cold Temperature; Electromyography; Face; Facial Pain; Hot Temperature; Hyperalgesia; Injections, Intradermal; Male; Neural Conduction; Neurons; Physical Stimulation; Purines; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents; Synaptic Transmission; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels

2014
Possible involvement of convergent nociceptive input to medullary dorsal horn neurons in intraoral hyperalgesia following peripheral nerve injury.
    Cellular and molecular neurobiology, 2015, Volume: 35, Issue:3

    Topics: Animals; Capsaicin; Hyperalgesia; Male; Medulla Oblongata; Mouth; Nociceptors; Pain Measurement; Peripheral Nerve Injuries; Posterior Horn Cells; Rats; Rats, Sprague-Dawley

2015
Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:6

    Topics: Acid Sensing Ion Channels; Amiloride; Animals; Blotting, Western; Capsaicin; Cnidarian Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Pyridines; Rats; Sulfones; Time Factors; TRPV Cation Channels

2014
Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats.
    Journal of neuroscience methods, 2015, Jan-15, Volume: 239

    Topics: Animals; Capsaicin; Consciousness; Grooming; Hyperalgesia; Isothiocyanates; Male; Mouth Mucosa; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Stimulation, Chemical; Time Factors

2015
Antinociceptive effect of botulinum toxin type A on experimental abdominal pain.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Botulinum Toxins, Type A; Capsaicin; Colitis; Disease Models, Animal; Hyperalgesia; Male; Pain Measurement; Pain, Referred; Peritonitis; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord; Visceral Pain

2014
Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats.
    Neuroscience, 2015, Feb-12, Volume: 286

    Topics: Analgesics; Animals; Capsaicin; Chronic Pain; Dinoprostone; Hyperalgesia; Male; Nociception; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, mu; Rotarod Performance Test; Somatostatin

2015
Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis.
    Brain, behavior, and immunity, 2015, Volume: 45

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Capsaicin; Disease Models, Animal; Diterpenes; Edema; Hindlimb; Hyperalgesia; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Nociceptors; Pain Threshold; Peroxidase; Reactive Oxygen Species; Sensory System Agents; Somatostatin; Tarsus, Animal; TRPV Cation Channels; X-Ray Microtomography

2015
The role of TRPV1 channels in carrageenan-induced mechanical hyperalgesia in mice.
    Neuroreport, 2015, Feb-11, Volume: 26, Issue:3

    Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Functional Laterality; Hyperalgesia; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Sensory System Agents; Touch; TRPV Cation Channels

2015
Influence of topical application of capsaicin, menthol and local anesthetics on intraoral somatosensory sensitivity in healthy subjects: temporal and spatial aspects.
    Experimental brain research, 2015, Volume: 233, Issue:4

    Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Local; Antipruritics; Capsaicin; Dose-Response Relationship, Drug; Facial Pain; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Menthol; Pain Threshold; Sensory System Agents; Time Factors; Visual Analog Scale; Young Adult

2015
Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms.
    Pain, 2015, Volume: 156, Issue:3

    Topics: Analysis of Variance; Animal Diseases; Animals; Area Under Curve; Astrocytes; Capsaicin; Glial Fibrillary Acidic Protein; Hyperalgesia; Hypoglycemic Agents; Injections, Intraventricular; Male; Neuralgia; Nociception; Oncogene Proteins v-fos; Pain Threshold; Pioglitazone; PPAR gamma; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Thiazolidinediones

2015
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.
    Neuron, 2015, Feb-18, Volume: 85, Issue:4

    Topics: Action Potentials; Animals; Biophysical Phenomena; Capsaicin; Cells, Cultured; CHO Cells; Cricetulus; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pain; Pain Measurement; Physical Stimulation; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2015
Cold and L-menthol-induced sensitization in healthy volunteers--a cold hypersensitivity analogue to the heat/capsaicin model.
    Pain, 2015, Volume: 156, Issue:5

    Topics: Administration, Topical; Adult; Capsaicin; Cold Temperature; Female; Hand; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Male; Menthol; Pain; Pain Measurement; Pain Threshold; Skin; Skin Temperature; Time Factors

2015
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
    Pain, 2015, Volume: 156, Issue:5

    Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels

2015
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
    Journal of Zhejiang University. Science. B, 2015, Volume: 16, Issue:3

    Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels

2015
TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity.
    Journal of neurophysiology, 2015, May-01, Volume: 113, Issue:9

    Topics: Aminopyridines; Animals; Biophysical Phenomena; Capsaicin; Female; Gene Expression Regulation; Glycoproteins; Hyperalgesia; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nociception; Pain Measurement; Pain Threshold; Piperazines; Sensory Receptor Cells; Skin; Species Specificity; Trigeminal Ganglion; TRPV Cation Channels

2015
A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats.
    Journal of neuroscience methods, 2015, Jun-15, Volume: 248

    Topics: Analgesics, Opioid; Animals; Capsaicin; Conditioning, Operant; Equipment Design; Facial Pain; Female; Hyperalgesia; Morphine; Pain Measurement; Pressure; Rats, Sprague-Dawley; Touch

2015
Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain.
    European journal of pain (London, England), 2016, Volume: 20, Issue:1

    Topics: Adult; Aged; Antipruritics; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Unmyelinated; Neuralgia; Outcome Assessment, Health Care; Prognosis

2016
Effectiveness of High-Frequency Electrical Stimulation Following Sensitization With Capsaicin.
    The journal of pain, 2015, Volume: 16, Issue:7

    Topics: Adult; Biophysical Phenomena; Capsaicin; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Reaction Time; Sensory System Agents; Time Factors; Transcutaneous Electric Nerve Stimulation; Young Adult

2015
HDAC4 is required for inflammation-associated thermal hypersensitivity.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:8

    Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Down-Regulation; Freund's Adjuvant; Histone Deacetylases; Hyperalgesia; Hypersensitivity; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Protein Precursors; Sensory Receptor Cells; Transcription, Genetic; TRPV Cation Channels

2015
Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans.
    Brain : a journal of neurology, 2015, Volume: 138, Issue:Pt 9

    Topics: Adult; Biophysics; Capsaicin; Electric Stimulation; Healthy Volunteers; Humans; Hyperalgesia; Long-Term Potentiation; Male; Nerve Fibers; Neural Conduction; Nociceptors; Pain; Pain Threshold; Physical Stimulation; Sensory System Agents; Skin; TRPV Cation Channels; Young Adult

2015
Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.
    Pain, 2015, Volume: 156, Issue:9

    Topics: Animals; Capsaicin; Cells, Cultured; Cyclic AMP; Female; Ganglia, Spinal; Humans; Hyperalgesia; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Parathyroid Hormone-Related Protein; Protein Kinase C-epsilon; Protein Transport; Receptor, Parathyroid Hormone, Type 1; TRPV Cation Channels; Up-Regulation

2015
Capsaicin 8% Patch for Central and Peripheral Neuropathic Pain of Persons with Incomplete Spinal Cord Injury: Two Case Reports.
    American journal of physical medicine & rehabilitation, 2015, Volume: 94, Issue:8

    Topics: Adult; Aged; Capsaicin; Humans; Hyperalgesia; Male; Neuralgia; Pain Measurement; Sensory System Agents; Spinal Cord Injuries; Transdermal Patch

2015
Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Jun-03, Volume: 35, Issue:22

    Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Male; Nerve Growth Factor; Nociception; Oxidative Stress; Pain Measurement; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Skin; TRPV Cation Channels

2015
Vitamin B complex attenuated heat hyperalgesia following infraorbital nerve constriction in rats and reduced capsaicin in vivo and in vitro effects.
    European journal of pharmacology, 2015, Sep-05, Volume: 762

    Topics: Animals; Calcium; Capsaicin; Carbamazepine; Constriction; Dose-Response Relationship, Drug; Drug Synergism; HEK293 Cells; Humans; Hyperalgesia; Male; Orbit; Rats; Rats, Wistar; TRPV Cation Channels; Vitamin B Complex

2015
Enhanced spinal neuronal responses as a mechanism for the increased nociceptive sensitivity of interleukin-4 deficient mice.
    Experimental neurology, 2015, Volume: 271

    Topics: Action Potentials; Age Factors; Animals; Capsaicin; Hyperalgesia; Interleukin-4; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pain Measurement; Pain Threshold; Physical Stimulation; Pupil Disorders; Reaction Time; Spinal Cord; Statistics, Nonparametric; Time Factors

2015
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
    Neuroimmunomodulation, 2015, Volume: 22, Issue:6

    Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Kaolin; Knee Joint; Male; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Synovial Fluid

2015
Synovial TRPV1 is upregulated by 17-β-estradiol and involved in allodynia of inflamed temporomandibular joints in female rats.
    Archives of oral biology, 2015, Volume: 60, Issue:9

    Topics: Animals; Blotting, Western; Capsaicin; Cyclooxygenase 2; Estradiol; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Nerve Growth Factor; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Temporomandibular Joint; Temporomandibular Joint Disorders; Transcriptional Activation; TRPV Cation Channels; Up-Regulation

2015
Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.
    Journal of natural medicines, 2016, Volume: 70, Issue:1

    Topics: Alkaloids; Analgesics; Animals; Calcium; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Evodia; Ganglia, Spinal; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Male; Medicine, Chinese Traditional; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Plant Extracts; Quinazolines; Quinolines; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2016
Characterizing pinprick-evoked brain potentials before and after experimentally induced secondary hyperalgesia.
    Journal of neurophysiology, 2015, Volume: 114, Issue:5

    Topics: Adult; Capsaicin; Cerebral Cortex; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Nociception; Pain; Pain Measurement; Physical Stimulation; Young Adult

2015
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
    Nature medicine, 2015, Volume: 21, Issue:11

    Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; Female; Flagellin; Ganglia, Spinal; Humans; Hyperalgesia; Lidocaine; Male; Mice; Mice, Knockout; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuralgia; Neurofilament Proteins; Neurons; Paclitaxel; Peripheral Nerve Injuries; Sensory System Agents; Toll-Like Receptor 5

2015
Peripheral sensitization reduces laser-evoked potential habituation.
    Neurophysiologie clinique = Clinical neurophysiology, 2015, Volume: 45, Issue:6

    Topics: Capsaicin; Central Nervous System; Electroencephalography; Evoked Potentials; Female; Habituation, Psychophysiologic; Hand; Humans; Hyperalgesia; Lasers; Male; Pain; Peripheral Nerves; Reaction Time; Reference Standards; Sensation; Young Adult

2015
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
    Anesthesiology, 2016, Volume: 124, Issue:5

    Topics: Animals; Bicuculline; Capsaicin; Excitatory Amino Acid Antagonists; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Nerve Fibers, Unmyelinated; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, GABA-B

2016
Nonparalytic botulinum molecules for the control of pain.
    Pain, 2016, Volume: 157, Issue:5

    Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Cell Count; Cell Proliferation; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Keratinocytes; Male; Motor Activity; Nerve Fibers, Unmyelinated; Neuralgia; Neuromuscular Agents; Pain Measurement; Pain Threshold; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn

2016
Involvement of mast cells and proteinase-activated receptor 2 in oxaliplatin-induced mechanical allodynia in mice.
    Pharmacological research, 2016, Volume: 105

    Topics: Animals; Antineoplastic Agents; Capsaicin; Cell Degranulation; Hyperalgesia; Male; Mast Cells; Mice, Inbred C57BL; Organoplatinum Compounds; Oxaliplatin; Receptor, PAR-2; Sensory System Agents

2016
The evaluation of neural and vascular hyper-reactivity for sensitive skin.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2016, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Capsaicin; Female; Genetic Predisposition to Disease; Humans; Hyperalgesia; Lactic Acid; Male; Middle Aged; Neurovascular Coupling; Pain Perception; Sensory System Agents; Skin; Skin Tests; TRPV Cation Channels; Young Adult

2016
TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception.
    Scientific reports, 2016, Feb-23, Volume: 6

    Topics: Animals; Calcium; Capsaicin; CHO Cells; Conditioning, Operant; Cricetulus; Cyclin-Dependent Kinase 5; Drinking; Gene Expression; HEK293 Cells; Hot Temperature; Humans; Hydrogen-Ion Concentration; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nociception; Pain Threshold; Patch-Clamp Techniques; Phosphorylation; Rats; Trigeminal Ganglion; TRPV Cation Channels

2016
The prokineticin Bv8 sensitizes cutaneous terminals of female mice to heat.
    European journal of pain (London, England), 2016, Volume: 20, Issue:8

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Female; Gastrointestinal Hormones; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Nerve Fibers; Neuropeptides; Nociceptors; Peripheral Nerves; Skin

2016
Enhanced Area of Secondary Hyperalgesia in Women with Multiple Stressful Life Events: A Pilot Study.
    Pain medicine (Malden, Mass.), 2016, Volume: 17, Issue:10

    Topics: Adolescent; Capsaicin; Female; Humans; Hyperalgesia; Life Change Events; Pain Measurement; Pilot Projects; Stress, Psychological; Young Adult

2016
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.
    Molecular pain, 2016, Volume: 12

    Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Capsaicin; Disease Models, Animal; Electric Stimulation; Hyperalgesia; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; Magnetic Resonance Imaging; Nociception; Osteoarthritis, Knee; Pain; Rats, Sprague-Dawley

2016
Contribution of capsaicin-sensitive primary afferents to mechanical hyperalgesia induced by ventral root transection in rats: the possible role of BDNF.
    Neurological research, 2016, Volume: 38, Issue:1

    Topics: Animals; Brain-Derived Neurotrophic Factor; Capsaicin; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pain Threshold; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory System Agents; Spinal Nerve Roots; Statistics, Nonparametric; Transfection

2016
Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways.
    Journal of neurophysiology, 2016, 08-01, Volume: 116, Issue:2

    Topics: Adult; Afferent Pathways; Brain; Capsaicin; Central Nervous System Sensitization; Electric Stimulation; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Nociceptors; Pain; Pain Measurement; Reaction Time; ROC Curve; Signal-To-Noise Ratio; Skin; Young Adult

2016
The Detection of Small-Fiber Neuropathies in Burning Mouth Syndrome and Iatrogenic Lingual Nerve Injuries: Use of Quantitative Sensory Testing.
    Journal of oral & facial pain and headache, 2016,Spring, Volume: 30, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Burning Mouth Syndrome; Capsaicin; Cold Temperature; Ethyl Chloride; Female; Hot Temperature; Humans; Hyperalgesia; Hypesthesia; Iatrogenic Disease; Lingual Nerve Injuries; Male; Middle Aged; Nerve Fibers; Pain Measurement; Pain Perception; Paresthesia; Sensory System Agents; Thermosensing; Tongue

2016
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
    Molecular pain, 2016, Volume: 12

    Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels

2016
Impaired diffuse noxious inhibitory controls in specific alternation of rhythm in temperature-stressed rats.
    European journal of pharmacology, 2016, Aug-05, Volume: 784

    Topics: Animals; Capsaicin; Diffuse Noxious Inhibitory Control; Heat-Shock Response; Hyperalgesia; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley

2016
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016, Volume: 65, Issue:9

    Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Edema; Hyperalgesia; Knee Joint; Male; Mice, Inbred C57BL; Mice, Knockout; Neurogenic Inflammation; Pain; Protein Precursors; Receptor, PAR-2; Receptors, Neurokinin-1; Substance P; Tachykinins; Touch; TRPV Cation Channels; Tryptases

2016
Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Animals; Capsaicin; Cerebellum; Female; Frontal Lobe; Gyrus Cinguli; Hot Temperature; Humans; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis; Magnetic Resonance Imaging; Male; Pain; Somatosensory Cortex; Tail; Thermosensing

2016
Multiple impairments of cutaneous nociceptor function induced by cardiotoxic doses of Adriamycin in the rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 2016, Volume: 389, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Biomarkers; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Cardiotoxicity; Carrageenan; Disease Models, Animal; Doxorubicin; Hyperalgesia; Male; Motor Activity; Mustard Plant; Nociception; Plant Oils; Rats, Wistar; Regional Blood Flow; Sensory Receptor Cells; Skin; Time Factors; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Vasodilation

2016
Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat.
    BMC pharmacology & toxicology, 2016, 07-21, Volume: 17, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Pain Measurement; Rats; Rats, Sprague-Dawley

2016
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
    Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:12

    Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25

2016
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
    Experimental neurology, 2016, Volume: 285, Issue:Pt A

    Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Hyperalgesia; Indenes; K Cl- Cotransporters; Lipopolysaccharides; Male; MAP Kinase Signaling System; Muscimol; Nociception; Pain Measurement; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Potassium Chloride Symporter Inhibitors; Spinal Cord Injuries; Symporters; Time Factors

2016
Stimulating TRPV1 externalization and synthesis in dorsal root ganglion neurons contributes to PGE2 potentiation of TRPV1 activity and nociceptor sensitization.
    European journal of pain (London, England), 2017, Volume: 21, Issue:4

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Male; Neurons; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; TRPV Cation Channels

2017
Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization.
    Experimental neurology, 2017, Volume: 288

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cadherins; Capsaicin; Disease Models, Animal; Electroshock; Extracellular Signal-Regulated MAP Kinases; GABA Agonists; Hyperalgesia; Immunoglobulin G; K Cl- Cotransporters; Male; MAP Kinase Signaling System; Muscimol; Nociception; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, trkB; Spinal Cord Injuries; Symporters

2017
Neurogenic hyperalgesia: illuminating its mechanisms with an infrared laser.
    The Journal of physiology, 2016, 11-15, Volume: 594, Issue:22

    Topics: Capsaicin; Hyperalgesia; Neurogenesis; Skin

2016
Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.
    Scientific reports, 2016, 11-25, Volume: 6

    Topics: Animals; Capsaicin; Cyclopentanes; Disease Models, Animal; Hyperalgesia; Liver; Male; Mice; Morpholines; Nociception; Pain Measurement; Pain Threshold; Pentazocine; Receptors, sigma; Sigma-1 Receptor

2016
SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
    Neuron, 2016, Dec-21, Volume: 92, Issue:6

    Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Ganglia, Spinal; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Mice; Mice, Knockout; Microfilament Proteins; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neuralgia; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Sensory System Agents; Spinal Cord; TRPV Cation Channels

2016
Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:7

    Topics: Administration, Oral; Adult; Analgesics; Capsaicin; Cross-Over Studies; Dermatitis, Contact; Electroencephalography; Evoked Potentials, Somatosensory; Female; Healthy Volunteers; Humans; Hyperalgesia; Lasers; Male; Middle Aged; Pain; Pain Measurement; Placebos; Single-Blind Method; Skin; Treatment Outcome; Ultraviolet Rays; Young Adult

2017
Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study.
    European journal of pain (London, England), 2017, Volume: 21, Issue:6

    Topics: Adult; Capsaicin; Female; Healthy Volunteers; Histamine; Humans; Hyperalgesia; Male; Nociceptors; Pain Measurement; Paresthesia; Pruritus; Skin; Young Adult

2017
Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1'-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model.
    Bioorganic & medicinal chemistry letters, 2017, 04-01, Volume: 27, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Capsaicin; Heterocyclic Compounds, 3-Ring; Hyperalgesia; Ketoprofen; Mice; Nociception; Pain; Pyrimidines; Spiro Compounds

2017
Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats.
    Neuropeptides, 2017, Volume: 62

    Topics: Animals; Antipruritics; Capsaicin; Consciousness; Female; Hyperalgesia; Nerve Fibers; Neurotransmitter Agents; Nociceptors; Pain; Peptides; Rats, Wistar; Sciatic Nerve; Sensory Receptor Cells; Somatostatin

2017
Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats.
    Neurochemical research, 2008, Volume: 33, Issue:10

    Topics: Animals; Capsaicin; Chronic Disease; Electric Stimulation; Evoked Potentials; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Male; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; TRPV Cation Channels

2008
Morphine inhibits herpetic allodynia through mu-opioid receptors induced in Abeta-fiber neurons.
    Neuroreport, 2008, Jun-11, Volume: 19, Issue:9

    Topics: Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Mice; Mice, Inbred C57BL; Morphine; Narcotics; Neurons, Afferent; Pain Measurement; Pain Threshold; Receptors, Opioid, mu; Sensory System Agents; Simplexvirus

2008
Central representation of cold-evoked pain relief in capsaicin induced pain: an event-related fMRI study.
    Pain, 2008, Oct-15, Volume: 139, Issue:2

    Topics: Adult; Capsaicin; Cold Temperature; Evoked Potentials, Somatosensory; Humans; Hyperalgesia; Hypothermia, Induced; Magnetic Resonance Imaging; Male; Middle Aged; Somatosensory Cortex; Young Adult

2008
Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion Buthus martensi Karch.
    Neuroscience research, 2008, Volume: 62, Issue:2

    Topics: Animals; Capsaicin; Diterpenes; Edema; Hindlimb; Hyperalgesia; Immunohistochemistry; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Spinal Cord

2008
Contralateral hyperalgesia and allodynia following intradermal capsaicin injection in man.
    Rheumatology (Oxford, England), 2008, Volume: 47, Issue:9

    Topics: Adult; Aged; Arthritis, Rheumatoid; Capsaicin; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Neural Pathways; Pain Measurement; Pain, Referred

2008
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
    Brain, behavior, and immunity, 2009, Volume: 23, Issue:1

    Topics: Analysis of Variance; Animals; Blotting, Western; Capsaicin; Cell Line; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; G-Protein-Coupled Receptor Kinases; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Pain Threshold; Peroxidase; Proto-Oncogene Proteins c-fos; Visceral Afferents

2009
Ultraviolet-B induced inflammation of human skin: characterisation and comparison with traditional models of hyperalgesia.
    European journal of pain (London, England), 2009, Volume: 13, Issue:5

    Topics: Adult; Burns; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Inflammation; Male; Models, Neurological; Nociceptors; Pain Threshold; Radiation Dosage; Sensory Receptor Cells; Sensory System Agents; Skin; Sunburn; Time Factors; Ultraviolet Rays; Young Adult

2009
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
    Bioorganic & medicinal chemistry, 2008, Sep-15, Volume: 16, Issue:18

    Topics: Administration, Oral; Analgesics; Animals; Arachidonic Acids; Calcium; Capsaicin; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hyperalgesia; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; TRPV Cation Channels

2008
Surgical incision can alter capsaicin-induced central sensitization in rat brainstem nociceptive neurons.
    Neuroscience, 2008, Oct-15, Volume: 156, Issue:3

    Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Capsaicin; Hyperalgesia; Lidocaine; Male; Mechanoreceptors; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Temporomandibular Joint; Trigeminal Nucleus, Spinal

2008
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
    The European journal of neuroscience, 2008, Volume: 28, Issue:6

    Topics: Alcoholic Neuropathy; Animals; Behavior, Animal; Capsaicin; Catecholamines; Clorgyline; Desipramine; Enzyme Inhibitors; Ethanol; Ganglia, Spinal; Hyperalgesia; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; Nociceptors; Norepinephrine Plasma Membrane Transport Proteins; Oligonucleotides, Antisense; Pargyline; Rats; Rats, Sprague-Dawley; Sensory System Agents

2008
Change of AMPA receptors in spinal nociceptive synapses during inflammatory hyperalgesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Oct-08, Volume: 28, Issue:41

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Humans; Hyperalgesia; Inflammation; Long-Term Potentiation; Nociceptors; Receptors, AMPA; Sensory System Agents; Spinal Cord; Synapses; Synaptic Transmission

2008
Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat.
    Gut, 2009, Volume: 58, Issue:2

    Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Corticosterone; Defecation; Electromyography; Endocannabinoids; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Microscopy, Fluorescence; Models, Animal; Morpholines; Naphthalenes; Pain Threshold; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Spectrum Analysis; Stress, Psychological; TRPV Cation Channels

2009
Postherpetic neuralgia--fighting pain with fire.
    The Lancet. Neurology, 2008, Volume: 7, Issue:12

    Topics: Administration, Cutaneous; Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Neuralgia, Postherpetic; Nociceptors; Pain Measurement; Randomized Controlled Trials as Topic; Sensory Receptor Cells; Sensory System Agents

2008
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
    Brain research, 2009, Jan-12, Volume: 1248

    Topics: Amino Acids; Animals; Capsaicin; Colforsin; Electrophysiological Phenomena; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Nociceptors; Pain; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; TRPV Cation Channels; Xanthenes

2009
Involvement of neuronal, inducible and endothelial nitric oxide synthases in capsaicin-induced muscle hypersensitivity.
    European journal of pain (London, England), 2009, Volume: 13, Issue:9

    Topics: Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Immunohistochemistry; Male; Masseter Muscle; Myositis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Time Factors; Trigeminal Caudal Nucleus; Up-Regulation

2009
Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents.
    Pharmacology, 2009, Volume: 83, Issue:2

    Topics: Analgesics, Non-Narcotic; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Intracellular Fluid; Mice; Nefopam; Potassium Chloride; Rats; Sensory Receptor Cells; Sensory System Agents; TRPV Cation Channels

2009
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.
    Pain, 2009, Volume: 141, Issue:3

    Topics: Animals; Capsaicin; Cell Line, Transformed; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hyperalgesia; Male; Mice; Pain Measurement; Pain Threshold; Protein Binding; Pyrazoles; Reaction Time; Receptors, Serotonin; Serotonin Agents

2009
Persistent pain is dependent on spinal mitochondrial antioxidant levels.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-07, Volume: 29, Issue:1

    Topics: Analysis of Variance; Animals; Antioxidants; Capsaicin; Ditiocarb; Dose-Response Relationship, Drug; Foot; Free Radical Scavengers; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Knockout; Mitochondria; Pain; Pain Measurement; Pain Threshold; Reactive Oxygen Species; Spinal Cord; Stilbamidines; Superoxide Dismutase

2009
Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue.
    Experimental brain research, 2009, Volume: 194, Issue:2

    Topics: Adult; Analysis of Variance; Capsaicin; Drug Interactions; Glutamic Acid; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Tendons; Young Adult

2009
TPRV1 expression defines functionally distinct pelvic colon afferents.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-21, Volume: 29, Issue:3

    Topics: Action Potentials; Animals; Biophysics; Capsaicin; Colon; Female; Ganglia, Spinal; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mustard Plant; Pain Threshold; Pelvis; Physical Stimulation; Plant Oils; Sensory Receptor Cells; Sensory System Agents; Statistics, Nonparametric; TRPV Cation Channels; Visceral Afferents

2009
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.
    Gut, 2009, Volume: 58, Issue:6

    Topics: Alkynes; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Ceruletide; Cystathionine gamma-Lyase; Ganglia, Spinal; Glycine; Hydrogen Sulfide; Hyperalgesia; Immunohistochemistry; Male; Mibefradil; Mice; Nociceptors; Oncogene Proteins v-fos; Pancreas; Pancreatitis, Acute Necrotizing; Rats; Rats, Wistar; Sulfides

2009
Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers.
    Journal of pharmacological sciences, 2009, Volume: 109, Issue:2

    Topics: Animals; Capsaicin; Glutamic Acid; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sensory System Agents; Time Factors; TRPV Cation Channels

2009
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Feb-25, Volume: 29, Issue:8

    Topics: Analgesics, Opioid; Animals; Bicuculline; Blood Pressure; Capsaicin; Disease Models, Animal; Drug Resistance; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Glycine; Hyperalgesia; Male; Morphine; Nonlinear Dynamics; Oncogene Proteins v-fos; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Strychnine

2009
Independent psychophysical measurement of experimental modulations in the somatotopy of cutaneous heat-pain stimuli.
    Somatosensory & motor research, 2009, Volume: 26, Issue:1

    Topics: Adult; Brain Mapping; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Lasers; Male; Neuropsychological Tests; Nociceptors; Pain; Perception; Physical Stimulation; Psychophysics; Sensory System Agents; Somatosensory Cortex; Young Adult

2009
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
    Journal of neurophysiology, 2009, Volume: 101, Issue:5

    Topics: Action Potentials; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glutamic Acid; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Naloxone; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; TRPV Cation Channels

2009
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
    Psychopharmacology, 2009, Volume: 205, Issue:1

    Topics: Analysis of Variance; Animals; Brain; Capsaicin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Hyperalgesia; Mice; Morpholines; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pentazocine; Physical Stimulation; Protein Binding; Radioligand Assay; Reaction Time; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Tritium

2009
Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.
    Neuroscience letters, 2009, Jul-17, Volume: 458, Issue:2

    Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Pain Threshold; Physical Stimulation; RNA, Messenger; Time Factors; TRPM Cation Channels; Up-Regulation

2009
Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice.
    Pain, 2009, Volume: 143, Issue:3

    Topics: Animals; Anisoles; Capsaicin; DNA; Ethylenediamines; Female; Hyperalgesia; Mice; Mice, Knockout; Morpholines; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Piperazines; Polymerase Chain Reaction; Propylamines; Reaction Time; Receptors, sigma; Sensory Receptor Cells; Sensory System Agents; Sigma-1 Receptor; Spinal Cord

2009
Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system.
    Pain, 2009, Volume: 144, Issue:1-2

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Eugenol; Gene Expression Regulation; Hyperalgesia; Jaw; Lectins; Male; Masticatory Muscles; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reflex; Sodium Channels; Tetrodotoxin; Tooth; Trigeminal Ganglion; Trigeminal Nerve; TRPV Cation Channels

2009
Differential effect of capsaicin treatment on pain-related behaviors after plantar incision.
    The journal of pain, 2009, Volume: 10, Issue:6

    Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Foot; Hindlimb; Hot Temperature; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Wound Healing

2009
Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia.
    Experimental brain research, 2009, Volume: 195, Issue:3

    Topics: Adult; Analysis of Variance; Attention; Capsaicin; Female; Humans; Hyperalgesia; Male; Neuropsychological Tests; Pain; Pain Measurement; Perception; Photic Stimulation; Physical Stimulation; Sensory System Agents; Task Performance and Analysis; Young Adult

2009
Differentiating thermal allodynia and hyperalgesia using dynamic hot and cold plate in rodents.
    The journal of pain, 2009, Volume: 10, Issue:7

    Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Cold Temperature; Dimethyl Sulfoxide; Escape Reaction; Hindlimb; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Time Factors

2009
Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates.
    Pain, 2009, Volume: 144, Issue:1-2

    Topics: Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biophysics; Calcium-Binding Proteins; Capsaicin; Electric Stimulation; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Interleukin-6; Macrophage Colony-Stimulating Factor; Male; Matrix Metalloproteinase 3; Microfilament Proteins; Microglia; Minocycline; Nerve Fibers, Unmyelinated; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Sciatic Nerve; Time Factors

2009
PGE(2)-induced lasting nociception to heat: evidences for a selective involvement of A-delta fibres in the hyperpathic component of hyperalgesia.
    European journal of pain (London, England), 2010, Volume: 14, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dimethyl Sulfoxide; Dinoprostone; Hot Temperature; Hyperalgesia; Indomethacin; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar

2010
Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.
    Neuroscience letters, 2009, Jul-03, Volume: 457, Issue:3

    Topics: Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hindlimb; Hyperalgesia; Male; Oligopeptides; Pain Measurement; Peptides, Cyclic; Physical Stimulation; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sensory System Agents; Temperature; TRPV Cation Channels

2009
Role of RVM neurons in capsaicin-evoked visceral nociception and referred hyperalgesia.
    European journal of pain (London, England), 2010, Volume: 14, Issue:2

    Topics: Abdomen; Animals; Behavior, Animal; Blood Pressure; Capsaicin; Colon; Electrophysiology; Hyperalgesia; Male; Medulla Oblongata; Microelectrodes; Microinjections; Neurons; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2010
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.
    Pain, 2009, Volume: 144, Issue:3

    Topics: Acrylamides; Afferent Pathways; Animals; Ankyrins; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Hyperalgesia; Injections, Intramuscular; Male; Masticatory Muscles; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels

2009
Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:4

    Topics: Analgesics; Animals; Bradykinin; Capsaicin; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hot Temperature; Hyperalgesia; Immersion; Inflammation; Male; Mice; Motor Activity; Organoselenium Compounds; Pain Measurement; Reaction Time; Tetradecanoylphorbol Acetate

2009
Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus.
    European journal of pain (London, England), 2010, Volume: 14, Issue:3

    Topics: Adult; Analysis of Variance; Body Temperature; Capsaicin; Cerebral Cortex; Electric Stimulation; Electroencephalography; Esophagus; Evoked Potentials, Somatosensory; Female; Humans; Hydrochloric Acid; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Rectum

2010
Axotomy depletes intracellular calcium stores in primary sensory neurons.
    Anesthesiology, 2009, Volume: 111, Issue:2

    Topics: Animals; Axons; Axotomy; Caffeine; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Central Nervous System Stimulants; Endoplasmic Reticulum; Hyperalgesia; Ionomycin; Ligation; Male; Nerve Degeneration; Pain Measurement; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Sciatic Nerve; Sensory Receptor Cells; Spinal Nerves; Thapsigargin

2009
Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice.
    The journal of pain, 2009, Volume: 10, Issue:9

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Hyperalgesia; Intermediate Filament Proteins; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nestin; Pain Measurement; Pain Threshold; Peptide Fragments; Physical Stimulation; Receptor Activity-Modifying Protein 1; Receptor Activity-Modifying Proteins; Sensory System Agents

2009
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.
    Gastroenterology, 2009, Volume: 137, Issue:6

    Topics: Action Potentials; Afferent Pathways; Animals; Bradykinin; Capsaicin; Colitis; Colon; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroanatomical Tract-Tracing Techniques; Nodose Ganglion; Pain Measurement; Pelvis; Pressure; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Nerves; Stimulation, Chemical; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel

2009
Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism.
    Pain, 2009, Volume: 145, Issue:3

    Topics: Acupuncture Points; Adrenergic alpha-Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Electroacupuncture; Functional Laterality; Hyperalgesia; Male; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phentolamine; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Touch

2009
Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.
    Brain research, 2009, Oct-27, Volume: 1295

    Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Male; Mice; Motor Activity; Neurons; Oleanolic Acid; Opioid Peptides; Pain; Pain Measurement; Physical Stimulation; Protein Kinase C; Psychomotor Performance; Rats; Rats, Wistar; Serotonin; Signal Transduction; TRPV Cation Channels

2009
[The role of capsaicin-sensitive primary afferents in experimental sciatic pain].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2009, Jul-15, Volume: 47, Issue:14

    Topics: Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Hyperalgesia; Intervertebral Disc Displacement; Male; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sciatica; Spinal Nerve Roots

2009
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
    Pain, 2010, Volume: 148, Issue:1

    Topics: Analgesics; Animals; Benzimidazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Piperidines

2010
Effect of capsaicin treatment on nociceptors in rat glabrous skin one day after plantar incision.
    Pain, 2010, Volume: 148, Issue:1

    Topics: Action Potentials; Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Hyperalgesia; Lectins; Male; Nerve Fibers; Neural Conduction; Neurofilament Proteins; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Sensory System Agents; Skin; Statistics, Nonparametric; Stimulation, Chemical; Ubiquitin Thiolesterase

2010
Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation.
    The British journal of dermatology, 2010, Volume: 162, Issue:5

    Topics: Adult; Asian People; Black or African American; Capsaicin; Female; Hispanic or Latino; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Neurogenic Inflammation; Pain; Pain Measurement; Pain Threshold; Pruritus; Regional Blood Flow; Sensory Thresholds; Skin; White People; Young Adult

2010
Nociceptive sensitization by complement C5a and C3a in mouse.
    Pain, 2010, Volume: 148, Issue:2

    Topics: Action Potentials; Analysis of Variance; Animals; Calcineurin; Calcium; Capsaicin; Complement C3a; Complement C5a; Dose-Response Relationship, Drug; Exploratory Behavior; Ganglia, Spinal; Humans; Hyperalgesia; Immunologic Factors; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Nerve Fibers; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; RNA, Messenger; Sensory Receptor Cells; Skin

2010
Curcumin produces an antihyperalgesic effect via antagonism of TRPV1.
    Journal of dental research, 2010, Volume: 89, Issue:2

    Topics: Animals; Capsaicin; Cell Line; Curcumin; Facial Pain; Hot Temperature; Humans; Hyperalgesia; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney; Male; Nociceptors; Nose; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; TRPV Cation Channels

2010
Topically applied capsaicin inhibits sensitivity to touch but not to warmth or heat-pain in the region of secondary mechanical hyperalgesia.
    Somatosensory & motor research, 2009, Volume: 26, Issue:4

    Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Female; Functional Laterality; Humans; Hyperalgesia; Male; Middle Aged; Sensory System Agents; Sensory Thresholds; Touch; Young Adult

2009
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
    Pharmacological research, 2010, Volume: 61, Issue:6

    Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Carrageenan; Hyperalgesia; Inflammation; Mice; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels

2010
Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray.
    Brain research, 2010, Apr-30, Volume: 1328

    Topics: Analgesia; Analgesics; Animals; Benzoxazines; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Nociceptors; Periaqueductal Gray; Rats; Receptor, Cannabinoid, CB1; RNA, Messenger; TRPV Cation Channels; Up-Regulation

2010
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
    Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8

    Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels

2010
Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Ketamine; Pain; Pain Measurement; Sensory System Agents; Skin

2010
Trigeminal antihyperalgesic effect of intranasal carbon dioxide.
    Life sciences, 2010, Jul-03, Volume: 87, Issue:1-2

    Topics: Acid Sensing Ion Channels; Administration, Intranasal; Animals; Behavior, Animal; Capsaicin; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hyperalgesia; Male; Nasal Mucosa; Nerve Tissue Proteins; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channels; Trigeminal Nerve; TRPV Cation Channels

2010
Luminal serotonin time-dependently modulates vagal afferent driven antinociception in response to colorectal distention in rats.
    Neurogastroenterology and motility, 2011, Volume: 23, Issue:1

    Topics: Afferent Pathways; Analgesics; Animals; Capsaicin; Colon; Dilatation, Pathologic; Food Hypersensitivity; Granisetron; Hyperalgesia; Intestinal Mucosa; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Time Factors; Vagotomy; Vagus Nerve

2011
Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon.
    European journal of pharmacology, 2010, Nov-25, Volume: 647, Issue:1-3

    Topics: Animals; Capsaicin; Colon; Fenclonine; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Male; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin; TRPV Cation Channels; Viscera

2010
Sensitized peripheral nociception in experimental diabetes of the rat.
    Pain, 2010, Volume: 151, Issue:2

    Topics: Action Potentials; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Diabetes Mellitus, Experimental; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; In Vitro Techniques; Male; Nerve Fibers; Nociceptors; Pain Measurement; Pain Threshold; Rats; Reaction Time; Sciatic Nerve; Skin; Streptozocin; Substance P

2010
Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception.
    The Journal of physiology, 2010, Nov-01, Volume: 588, Issue:Pt 21

    Topics: Animals; Capsaicin; Dihydroxytryptamines; Hot Temperature; Hyperalgesia; Male; Models, Animal; Muscle, Skeletal; Naloxone; Nerve Fibers, Unmyelinated; Nociceptors; Rats; Rats, Sprague-Dawley; Reflex; Saline Solution, Hypertonic; Sciatic Nerve; Time Factors

2010
The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.
    Life sciences, 2010, Nov-20, Volume: 87, Issue:19-22

    Topics: Acute Disease; Animals; Benzamidines; Capsaicin; Ceruletide; Disease Models, Animal; Gene Expression Regulation; Guanidines; Hyperalgesia; Male; Mice; Oligopeptides; Pain; Pancreatitis; Proto-Oncogene Proteins c-fos; Receptor, PAR-2; Spinal Cord; TRPV Cation Channels

2010
Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain.
    Behavioural brain research, 2011, Mar-01, Volume: 217, Issue:2

    Topics: Adaptation, Physiological; Analysis of Variance; Animals; Capsaicin; Conditioning, Operant; Disease Models, Animal; Facial Pain; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley

2011
Eriodictyol: a flavonoid antagonist of the TRPV1 receptor with antioxidant activity.
    Biochemical pharmacology, 2011, Feb-15, Volume: 81, Issue:4

    Topics: Analgesics; Animals; Antioxidants; Capsaicin; Flavanones; Flavonoids; Hyperalgesia; Mice; Pain; Rats; TRPV Cation Channels

2011
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Dec-21, Volume: 107, Issue:51

    Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Fixatives; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Mice; Mice, Knockout; Nociceptors; Pain; Sensory System Agents; Vesicular Glutamate Transport Protein 2

2010
Cutaneous limb inflammation produces analgesia to pressure pain in the ipsilateral forehead of healthy volunteers.
    The journal of pain, 2011, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Analgesia; Capsaicin; Complex Regional Pain Syndromes; Female; Forearm; Forehead; Functional Laterality; Humans; Hyperalgesia; Inflammation; Irritants; Pain; Pain Perception; Pain Threshold; Pressure; Skin; Young Adult

2011
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat.
    Pain, 2011, Volume: 152, Issue:3

    Topics: Acetanilides; Analysis of Variance; Animals; Ankyrins; Calcium Channels; Capsaicin; Cholecystokinin; Cinnamomum zeylanicum; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; N-Methylaspartate; Pain Measurement; Peripheral Nervous System Diseases; Purines; Rats; Rats, Wistar; Sleep Deprivation; Spinal Cord; TRPA1 Cation Channel; TRPC Cation Channels

2011
Nociceptive cortical responses during capsaicin-induced tactile allodynia in mice with spinal dorsal column lesioning.
    Neuroscience research, 2011, Volume: 69, Issue:4

    Topics: Animals; Capsaicin; Functional Laterality; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Sensory System Agents; Somatosensory Cortex; Spinal Cord

2011
Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity.
    The Clinical journal of pain, 2011, Volume: 27, Issue:2

    Topics: Capsaicin; Drug Synergism; Female; Humans; Hyperalgesia; Male; Middle Aged; Multiple Chemical Sensitivity; Pain Measurement

2011
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation.
    Pain, 2011, Volume: 152, Issue:7

    Topics: Animals; Antineoplastic Agents; Atropine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chromatography, High Pressure Liquid; Cisplatin; Cricetinae; Cricetulus; Dipeptides; Disease Models, Animal; Drug Interactions; Ganglia, Spinal; Gene Expression Regulation; Guinea Pigs; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Piperazines; Pulmonary Artery; Quinazolines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensory Receptor Cells; Spectrometry, Mass, Electrospray Ionization; Superoxides; Tissue Culture Techniques; Transient Receptor Potential Channels; TRPA1 Cation Channel

2011
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
    Neuron, 2011, May-12, Volume: 70, Issue:3

    Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Capsaicin; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Humans; Hyperalgesia; Inflammation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nifedipine; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Plant Oils; Pregnenolone; Sensory Receptor Cells; Telemetry; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPM Cation Channels

2011
Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats.
    Journal of neuroscience methods, 2011, Jul-15, Volume: 199, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Genetic Therapy; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Morphine; Narcotics; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Second Messenger Systems; Spinal Cord; Stress, Mechanical

2011
Synthesis and pharmacological evaluation of a potent and selective σ1 receptor antagonist with high antiallodynic activity.
    Archiv der Pharmazie, 2011, Volume: 344, Issue:7

    Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Dioxanes; Disease Models, Animal; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Hyperalgesia; Male; Mice; Rats; Receptors, sigma; Sigma-1 Receptor

2011
Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
    The journal of headache and pain, 2011, Volume: 12, Issue:4

    Topics: Animals; Capsaicin; Cyclic AMP Response Element-Binding Protein; Hyperalgesia; Immunohistochemistry; Male; Pain; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sumatriptan; Trigeminal Caudal Nucleus; Tryptamines

2011
Central nervous system mast cells in peripheral inflammatory nociception.
    Molecular pain, 2011, Jun-03, Volume: 7

    Topics: Animals; Capsaicin; Carrageenan; Cell Count; Cell Degranulation; Central Nervous System; Female; Hyperalgesia; Long-Term Potentiation; Lumbar Vertebrae; Male; Mast Cells; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Nociceptors; Rats; Rats, Sprague-Dawley; Synapses; Thalamus; Time Factors

2011
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.
    American journal of physiology. Cell physiology, 2011, Volume: 301, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Allyl Compounds; Animals; Ankyrins; Behavior, Animal; Calcium; Calcium Channels; Capsaicin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Hydrogen-Ion Concentration; Hyperalgesia; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isocyanates; Maleimides; Membrane Potentials; Mice; Mice, Inbred Strains; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Nociception; Nociceptive Pain; Oocytes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spermine; Synaptic Transmission; Tachyphylaxis; Transient Receptor Potential Channels; Trigeminal Caudal Nucleus; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Xenopus laevis

2011
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.
    Blood, 2011, Sep-22, Volume: 118, Issue:12

    Topics: Action Potentials; Anemia, Sickle Cell; Animals; Capsaicin; Disease Models, Animal; Female; Humans; Hyperalgesia; Hypoxia; Isoquinolines; Male; Mice; Mice, Inbred Strains; Microelectrodes; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; TRPV Cation Channels; Urea

2011
Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:7

    Topics: Animals; Benzamides; Capsaicin; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Mice; Neuralgia; Quinolones; Tissue Distribution; TRPV Cation Channels

2011
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
    Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

    Topics: Administration, Oral; Amides; Animals; Capsaicin; Cyclohexanols; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Isoxazoles; Microsomes, Liver; Rats; Structure-Activity Relationship; TRPV Cation Channels

2011
Intradermal capsaicin as a neuropathic pain model in patients with unilateral sciatica.
    British journal of clinical pharmacology, 2012, Volume: 73, Issue:1

    Topics: Adult; Capsaicin; Case-Control Studies; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Models, Theoretical; Pain; Pain Measurement; Sciatica; Sensory System Agents

2012
Capsaicin prevents the hyperalgesia induced by peripheral group I mGluRs activation.
    Neuroscience letters, 2011, Aug-18, Volume: 500, Issue:3

    Topics: Afferent Pathways; Animals; Capsaicin; Hyperalgesia; Male; Nerve Fibers; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sciatic Nerve; Touch

2011
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
    Neuroscience, 2011, Oct-13, Volume: 193

    Topics: Analysis of Variance; Anilides; Animals; Ankyrins; Antineoplastic Agents, Phytogenic; Capsaicin; Carbazoles; Central Nervous System; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Oligopeptides; Paclitaxel; Pain Measurement; Physical Stimulation; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, PAR-2; Sulfonamides; Time Factors; TRPV Cation Channels; Tryptases; Type C Phospholipases

2011
Sex differences in neuropeptide content and release from rat dental pulp.
    Journal of endodontics, 2011, Volume: 37, Issue:8

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dental Pulp; Female; Hyperalgesia; Male; Mice; Nerve Growth Factor; Neurogenic Inflammation; Proestrus; Rats; Sex Characteristics

2011
Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1(TRPV1) and inflammatory mediators.
    Molecular pain, 2011, Jul-27, Volume: 7

    Topics: Animals; Blood Glucose; Body Weight; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Diterpenes; Glucose Tolerance Test; Hyperalgesia; Hyperglycemia; Inflammation Mediators; Injections, Intraperitoneal; Injections, Spinal; Insulin; Microglia; Pain; Posterior Horn Cells; Rats; Streptozocin; TRPV Cation Channels

2011
Dissecting itch and pain sensations in human skin.
    Pain, 2011, Volume: 152, Issue:11

    Topics: Acute Pain; Capsaicin; Female; Histamine; Humans; Hyperalgesia; Male; Skin

2011
Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice.
    Molecular pain, 2011, Oct-26, Volume: 7

    Topics: Animals; Anthracenes; Capsaicin; Carbamates; Hyperalgesia; KCNQ2 Potassium Channel; Magnesium Sulfate; Mice; Mice, Transgenic; Phenylenediamines; Prosencephalon; Proto-Oncogene Proteins c-fos; Somatosensory Cortex; Visceral Pain

2011
Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors.
    Journal of neurophysiology, 2012, Volume: 107, Issue:4

    Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Capsaicin; Hyperalgesia; Male; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Neurons; Nociception; Pain Threshold; Patch-Clamp Techniques; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sensory System Agents

2012
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
    Journal of pharmacological sciences, 2011, Volume: 117, Issue:3

    Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P

2011
The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.
    Anesthesia and analgesia, 2012, Volume: 114, Issue:1

    Topics: Ambroxol; Aniline Compounds; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Hot Temperature; Hyperalgesia; Injections, Spinal; Ischemia; Male; NAV1.8 Voltage-Gated Sodium Channel; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Time Factors

2012
Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat.
    Neuroscience, 2012, Feb-17, Volume: 203

    Topics: Animals; Capsaicin; Female; Hyperalgesia; Ketanserin; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan

2012
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice.
    Journal of orofacial pain, 2011,Fall, Volume: 25, Issue:4

    Topics: Acetone; Analgesics, Opioid; Animals; Capsaicin; Clomipramine; Disease Models, Animal; Formaldehyde; Hyperalgesia; Irritants; Male; Mice; Nociceptors; Orbit; Pruritus; Selective Serotonin Reuptake Inhibitors; Sensory System Agents; Tramadol; Transient Receptor Potential Channels; Trigeminal Nerve Injuries; Trigeminal Neuralgia; TRPA1 Cation Channel; TRPV Cation Channels; Vibrissae

2011
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism.
    Pflugers Archiv : European journal of physiology, 2012, Volume: 463, Issue:4

    Topics: Acetanilides; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Drug Hypersensitivity; Glutathione; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Paclitaxel; Peripheral Nervous System Diseases; Purines; Pyrroles; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2012
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3

    Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

2012
Absence of mechanical hyperalgesia after exercise (delayed onset muscle soreness) in neonatally capsaicin-treated rats.
    Neuroscience research, 2012, Volume: 73, Issue:1

    Topics: Animals; Animals, Newborn; Capsaicin; Hyperalgesia; Male; Muscle Contraction; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Time Factors

2012
Discovery of novel 5,5-diarylpentadienamides as orally available transient receptor potential vanilloid 1 (TRPV1) antagonists.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: Alkadienes; Amides; Analgesics; Animals; Blood-Brain Barrier; Calcium; Capsaicin; Dogs; Epstein-Barr Virus Nuclear Antigens; Haplorhini; HEK293 Cells; Humans; Hyperalgesia; Male; Microsomes, Liver; Neuralgia; Quinolones; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; TRPV Cation Channels

2012
Effects of perceived and exerted pain control on neural activity during pain relief in experimental heat hyperalgesia: a fMRI study.
    European journal of pain (London, England), 2012, Volume: 16, Issue:4

    Topics: Adult; Brain; Capsaicin; Cerebral Cortex; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Pain; Pain Management; Pain Measurement; Perception; Prefrontal Cortex; Young Adult

2012
Multiple chemical sensitivity: on the scent of central sensitization.
    International journal of hygiene and environmental health, 2013, Volume: 216, Issue:2

    Topics: Adult; Capsaicin; Central Nervous System Sensitization; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Multiple Chemical Sensitivity; Pain Measurement; Surveys and Questionnaires

2013
Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity.
    Experimental physiology, 2012, Volume: 97, Issue:11

    Topics: Adiponectin; Animals; Capsaicin; Carrageenan; Down-Regulation; Edema; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Morphine; Nitric Oxide Synthase Type II; Nociception; Obesity; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Zucker; Receptors, Leptin; RNA, Messenger; Spinal Cord; Tumor Necrosis Factor-alpha; Up-Regulation

2012
Alterations in microglia and astrocytes in the trigeminal nucleus caudalis by repetitive TRPV1 stimulation on the trigeminal nociceptors.
    Neuroreport, 2012, Jun-20, Volume: 23, Issue:9

    Topics: Animals; Astrocytes; Behavior, Animal; Calcium-Binding Proteins; Capsaicin; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Microfilament Proteins; Microglia; Nociceptors; Rats; Rats, Sprague-Dawley; Sensory System Agents; Trigeminal Caudal Nucleus; TRPV Cation Channels

2012
7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersen
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2

    Topics: Analgesics; Animals; Benzothiazoles; Body Temperature; Body Temperature Regulation; Capsaicin; CHO Cells; Cricetinae; Fever; Humans; Hyperalgesia; Hypersensitivity; Male; Mice; Mice, Inbred C57BL; Pyrimidines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiones; Transient Receptor Potential Channels; TRPV Cation Channels

2012
Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel transient receptor potential vanilloid 1 antagonist.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2

    Topics: Animals; Benzoxazines; Body Temperature; Capsaicin; Carrageenan; Central Nervous System Stimulants; HEK293 Cells; Humans; Hyperalgesia; Male; Pyridines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels

2012
Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.
    Pharmacological research, 2012, Volume: 66, Issue:3

    Topics: Analgesics; Animals; Body Temperature; Bronchoconstriction; Capsaicin; Edema; Female; Hyperalgesia; Hypothermia; Inflammation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neuralgia; Pain Measurement; Respiratory System; Sciatic Nerve; TRPV Cation Channels

2012
Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.
    Journal of neurophysiology, 2012, Volume: 108, Issue:5

    Topics: Action Potentials; Analysis of Variance; Anilides; Animals; Capsaicin; Cell Line, Tumor; Cell Movement; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Guanosine Diphosphate; Hyperalgesia; Lysophospholipids; Male; Melanoma; Mice; Organophosphonates; Pain Threshold; Patch-Clamp Techniques; Pertussis Toxin; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sensory Receptor Cells; Sensory System Agents; Sphingosine; Thionucleotides; Time Factors; Wound Healing

2012
Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects.
    Pain, 2012, Volume: 153, Issue:8

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Capsaicin; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Humans; Hyperalgesia; Lasers; Male; Middle Aged; Morphine; Oxycodone; Skin; Treatment Outcome; Ultraviolet Rays

2012
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.
    Anesthesiology, 2012, Volume: 117, Issue:2

    Topics: Anesthetics, Local; Animals; Antipruritics; Capsaicin; Disease Models, Animal; Drug Administration Routes; Drug Therapy, Combination; Hyperalgesia; Lidocaine; Male; Neuralgia; Peripheral Nerves; Rats; Rats, Sprague-Dawley

2012
Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Animals; Benzyl Alcohols; Capsaicin; Diabetic Neuropathies; Glucosides; Hyperalgesia; Rats; Sensory Receptor Cells; Streptozocin

2012
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
    Neuroscience, 2012, Sep-27, Volume: 221

    Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal

2012
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice.
    Molecular pain, 2012, Jul-28, Volume: 8

    Topics: Animals; Behavior, Animal; Calcium Channels; Capsaicin; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Ganglia, Spinal; Hyperalgesia; Isothiocyanates; Male; Menthol; Mice; Mice, Inbred C57BL; Nociception; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Transient Receptor Potential Channels; TRPA1 Cation Channel

2012
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats.
    Neuropharmacology, 2012, Volume: 63, Issue:8

    Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endocannabinoids; Formaldehyde; Hyperalgesia; Indoles; Male; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid

2012
Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Anesthetics, Local; Animals; Capsaicin; Gene Expression; Hyperalgesia; Lidocaine; Male; Mandibular Nerve; Myelin Sheath; Nerve Regeneration; Neuralgia; Nociceptors; Pain Management; Pain Threshold; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Trigeminal Nerve Injuries; TRPV Cation Channels

2012
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
    Neuropharmacology, 2012, Volume: 63, Issue:8

    Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxylic Acids; Diazepam; Endpoint Determination; GABA Antagonists; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Pain; Physical Stimulation; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles

2012
Temporal regularity determines the impact of electrical stimulation on tactile reactivity and response to capsaicin in spinally transected rats.
    Neuroscience, 2012, Dec-27, Volume: 227

    Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Electric Stimulation; Electroshock; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinal Cord Injuries; Time Factors; Touch

2012
De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion.
    The Journal of comparative neurology, 2013, Jun-01, Volume: 521, Issue:8

    Topics: Animals; Brachial Plexus; Brain Stem; Capsaicin; Cholera Toxin; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Microscopy, Confocal; Neural Pathways; Peripheral Nerve Injuries; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P

2013
Stimulation of cutaneous low threshold mechanoreceptors in mice after intracolonic capsaicin increases spinal c-Fos labeling in an NKCC1-dependent fashion.
    The journal of pain, 2013, Volume: 14, Issue:1

    Topics: Abdomen; Animals; Behavior, Animal; Bumetanide; Capsaicin; Colon; Diuretics; Dose-Response Relationship, Drug; Heart; Hyperalgesia; Immunohistochemistry; Injections; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Perfusion; Physical Stimulation; Proto-Oncogene Proteins c-fos; Skin; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Cord

2013
P2X₃ and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons.
    Neuroscience, 2013, Mar-01, Volume: 232

    Topics: Acrylamides; Anesthetics, Local; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Cells, Cultured; Hyperalgesia; Male; Masseter Muscle; Phosphorylation; Purinergic P2X Receptor Agonists; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Sensory Receptor Cells; Sensory System Agents; Skin; Touch; Trigeminal Ganglion; TRPV Cation Channels

2013
Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.
    The Journal of biological chemistry, 2013, Feb-08, Volume: 288, Issue:6

    Topics: A Kinase Anchor Proteins; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Capsaicin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Mice; Multiprotein Complexes; Nerve Tissue Proteins; Protein Kinase C; Sensory System Agents; TRPV Cation Channels

2013
Contribution of sensory C-fiber neuron injury to mechanical dynamic allodynia in a murine model of postherpetic neuralgia.
    Neuroreport, 2013, Feb-13, Volume: 24, Issue:3

    Topics: Animals; Antigens, Surface; Calcitonin Gene-Related Peptide; Capsaicin; Escape Reaction; Female; Functional Laterality; Hyperalgesia; Lectins, C-Type; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Nerve Fibers, Unmyelinated; Neuralgia, Postherpetic; Neurofilament Proteins; Pain Threshold; Reaction Time; Sensory Receptor Cells

2013
Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-16, Volume: 33, Issue:3

    Topics: Amino Acid Transport Systems, Acidic; Animals; Behavior, Animal; Capsaicin; Core Binding Factor Alpha 2 Subunit; Hyperalgesia; Ion Channels; Mechanoreceptors; Mice; Mice, Knockout; Nerve Endings; Neuralgia; Physical Stimulation; Skin; Tyrosine 3-Monooxygenase

2013
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
    Journal of ethnopharmacology, 2013, Mar-07, Volume: 146, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Acid; Hot Temperature; Hydrolyzable Tannins; Hyperalgesia; Male; Mice; Motor Activity; Phyllanthus; Phytotherapy

2013
Specific functioning of Cav3.2 T-type calcium and TRPV1 channels under different types of STZ-diabetic neuropathy.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:5

    Topics: Animals; Calcium; Calcium Channels, T-Type; Capsaicin; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Ganglia, Spinal; Hyperalgesia; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Sensory System Agents; TRPV Cation Channels

2013
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
    Pain, 2013, Volume: 154, Issue:4

    Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Fentanyl; Ganglia, Spinal; Humans; Hyperalgesia; Male; Membrane Potentials; Morphine; Mutagenesis, Site-Directed; Protein Binding; Rats; Receptors, Opioid, mu; Sensory Receptor Cells; Substance Withdrawal Syndrome; Tritium; TRPV Cation Channels

2013
Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats.
    Japanese journal of pharmacology, 2002, Volume: 89, Issue:2

    Topics: Amino Acid Sequence; Animals; Capsaicin; Hot Temperature; Hyperalgesia; Male; Pain; Peptide Fragments; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Thrombin

2002
Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization.
    Anesthesiology, 2002, Volume: 97, Issue:1

    Topics: Acetates; Adult; Amines; Analgesics; Capsaicin; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Humans; Hyperalgesia; Male

2002
Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Aug-01, Volume: 22, Issue:15

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Capsaicin; Colforsin; Dinoprostone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GTP-Binding Protein alpha Subunits, Gi-Go; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neurons, Afferent; Pain Measurement; Pertussis Toxin; Phosphorylation; Proline; Receptors, Drug; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella

2002
Effects of peripheral nerve injury on functional spinal VR1 receptors.
    Neuroreport, 2002, Jul-02, Volume: 13, Issue:9

    Topics: Action Potentials; Animals; Capsaicin; Denervation; Dose-Response Relationship, Drug; Down-Regulation; Hyperalgesia; Ligation; Nerve Fibers; Nerve Fibers, Myelinated; Neuralgia; Neuronal Plasticity; Nociceptors; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Physical Stimulation; Posterior Horn Cells; Rats; Receptors, Drug

2002
Heat hyperalgesia in humans: assessed by different stimulus temperature profiles.
    European journal of pain (London, England), 2002, Volume: 6, Issue:5

    Topics: Adult; Afferent Pathways; Body Temperature; Capsaicin; Female; Humans; Hyperalgesia; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain Measurement; Skin

2002
A unique representation of heat allodynia in the human brain.
    Neuron, 2002, Jul-18, Volume: 35, Issue:2

    Topics: Adult; Afferent Pathways; Brain; Brain Mapping; Capsaicin; Cerebrovascular Circulation; Functional Laterality; Humans; Hyperalgesia; Inflammation; Male; Nerve Fibers; Nerve Fibers, Myelinated; Nociceptors; Pain Measurement; Pain Threshold; Skin; Tomography, Emission-Computed

2002
Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteers.
    Experimental brain research, 2002, Volume: 146, Issue:2

    Topics: Adult; Afferent Pathways; Analgesics, Opioid; Capsaicin; Female; Humans; Hyperalgesia; Hypesthesia; Male; Mechanoreceptors; Muscle, Skeletal; Myofascial Pain Syndromes; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain Measurement; Physical Stimulation

2002
Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Sep-01, Volume: 22, Issue:17

    Topics: Animals; Behavior, Animal; Capsaicin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Dinoprostone; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hyperalgesia; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Phospholipids; Prostaglandins; Protein Kinase C; Receptor, Metabotropic Glutamate 5; Receptors, Drug; Receptors, Metabotropic Glutamate; Signal Transduction; Type C Phospholipases

2002
Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents.
    Neuroscience, 2002, Volume: 114, Issue:2

    Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Nerve Crush; Nerve Fibers, Unmyelinated; Neuralgia; Neurons, Afferent; Nociceptors; Oxidopamine; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Skin; Spinal Nerves; Sympathetic Fibers, Postganglionic

2002
Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Oct-01, Volume: 22, Issue:19

    Topics: Acetylcholine; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Capsaicin; Colitis; Colon; Cyclophosphamide; Cystitis; Disease Models, Animal; Drug Administration Routes; Homozygote; Hyperalgesia; Male; Mice; Mice, Knockout; Mustard Plant; NAV1.8 Voltage-Gated Sodium Channel; Neuropeptides; Pain; Pain Measurement; Plant Extracts; Plant Oils; Sodium Channels; Stimulation, Chemical; Urinary Bladder; Viscera

2002
Spinal neurons that possess the substance P receptor are required for the development of central sensitization.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Oct-15, Volume: 22, Issue:20

    Topics: Animals; Capsaicin; Cytotoxins; Hyperalgesia; Immunotoxins; Injections, Spinal; Male; N-Glycosyl Hydrolases; Neurons; Nociceptors; Pain Measurement; Physical Stimulation; Plant Proteins; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Stimulation, Chemical; Substance P

2002
The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1

    Topics: Algorithms; Animals; Anticonvulsants; Capsaicin; Carbamazepine; Dose-Response Relationship, Drug; Guinea Pigs; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptors, Drug; Sciatic Nerve

2003
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
    Brain research, 2003, Jan-31, Volume: 961, Issue:2

    Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosides; GTP-Binding Proteins; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels; Steroids; Tetraethylammonium

2003
A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans.
    Neuroscience letters, 2003, Feb-13, Volume: 337, Issue:3

    Topics: Analysis of Variance; Bee Venoms; Capsaicin; Humans; Hyperalgesia; Injections, Intradermal; Melitten; Neurogenic Inflammation; Pain; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Time Factors

2003
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
    The Journal of biological chemistry, 2003, Apr-18, Volume: 278, Issue:16

    Topics: Animals; Arachidonic Acids; Brain; Calcium; Calcium Channel Blockers; Capsaicin; Cattle; Cell Line; Cell Membrane; Cytosol; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Hyperalgesia; Inhibitory Concentration 50; Ions; Lipids; Male; Mass Spectrometry; Models, Chemical; Polyunsaturated Alkamides; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug; Temperature; Time Factors; TRPV Cation Channels

2003
Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:3

    Topics: Analgesia; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Gene Expression; Hot Temperature; Hyperalgesia; Male; Mice; Nerve Fibers; Pain; Pain Measurement; Receptors, Drug; TRPV Cation Channels

2003
Low-threshold heat receptor in chick sensory neurons is upregulated independently of nerve growth factor after nerve injury.
    Neuroscience, 2003, Volume: 117, Issue:3

    Topics: Animals; Capsaicin; Cells, Cultured; Chick Embryo; Chickens; Cobalt; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Nerve Growth Factor; Neurons; Neurons, Afferent; Patch-Clamp Techniques; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sciatic Nerve; Sodium Channels; Thermosensing; Time Factors; TRPV Cation Channels; Up-Regulation

2003
Cannabinoid agonists attenuate capsaicin-induced responses in human skin.
    Pain, 2003, Volume: 102, Issue:3

    Topics: Adult; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dronabinol; Female; Humans; Hyperalgesia; Male; Pain Measurement; Skin

2003
State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.
    Journal of neurochemistry, 2003, Volume: 85, Issue:3

    Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Disease Models, Animal; Diterpenes; Freund's Adjuvant; Ganglia, Spinal; Hindlimb; Hyperalgesia; Inflammation; Ligation; Male; Neurons; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System Diseases; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Drug

2003
Peripheral tackykinin and excitatory amino acid receptors mediate hyperalgesia induced by Phoneutria nigriventer venom.
    European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3

    Topics: Animals; Capsaicin; Edema; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hindlimb; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Spider Venoms

2003
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:1

    Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug

2003
Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2

    Topics: Afferent Pathways; Animals; Capsaicin; Diabetic Neuropathies; Disease Models, Animal; Hot Temperature; Hyperalgesia; Injections, Intravenous; Mice; Nerve Fibers, Myelinated; Neurons, Afferent; Pain; Phenotype; Receptors, Drug; Streptozocin

2003
SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia.
    Brain research, 2003, May-30, Volume: 973, Issue:2

    Topics: Animals; Capsaicin; Carrageenan; Dose-Response Relationship, Drug; Drug Administration Routes; Glutamates; Hyperalgesia; Inflammation; Lower Extremity; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Kainic Acid

2003
Aftersensations in experimental and clinical hypersensitivity.
    Pain, 2003, Volume: 103, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Pain; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Physical Stimulation; Time Factors; Wounds and Injuries

2003
A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin.
    Neuroscience, 2003, Volume: 119, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Hyperalgesia; Ligation; Male; Meloxicam; Morphine; Pain; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazines; Thiazoles; Thymic Factor, Circulating; Time Factors

2003
Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli.
    Neuroscience, 2003, Volume: 119, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Conditioning, Operant; Dose-Response Relationship, Drug; Escape Reaction; Female; Hot Temperature; Hyperalgesia; Immunotoxins; Injections, Spinal; Morphine; Pain Measurement; Rats; Rats, Long-Evans; Reaction Time; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P

2003
The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Hyperalgesia; Injections, Intradermal; Male; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide

2003
Functional MRI of the rat lumbar spinal cord involving painful stimulation and the effect of peripheral joint mobilization.
    Journal of magnetic resonance imaging : JMRI, 2003, Volume: 18, Issue:2

    Topics: Animals; Ankle Joint; Blood Gas Analysis; Blood Pressure; Capsaicin; Disease Models, Animal; Forelimb; Hyperalgesia; Injections, Intra-Articular; Injections, Subcutaneous; Lumbosacral Region; Magnetic Resonance Imaging; Pain; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Spinal Cord; Stimulation, Chemical

2003
Capsaicin-induced hyperalgesia and mu-opioid-induced antihyperalgesia in male and female Fischer 344 rats.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Buprenorphine; Capsaicin; Clinical Trials as Topic; Cycloparaffins; Disease Models, Animal; Female; Humans; Hyperalgesia; Male; Morphine; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Tetrahydronaphthalenes

2003
Spatial and temporal profiles of flare and hyperalgesia after intradermal capsaicin.
    Pain, 2003, Volume: 105, Issue:1-2

    Topics: Capsaicin; Hot Temperature; Humans; Hyperalgesia; Infrared Rays; Injections, Intradermal; Laser-Doppler Flowmetry; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Skin Temperature; Thermography; Time Factors; Urticaria; Vasodilation

2003
Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2003, Volume: 114, Issue:10

    Topics: Adult; Brain Mapping; Capsaicin; Cerebral Cortex; Evoked Potentials; Female; Functional Laterality; Hand; Humans; Hyperalgesia; Injections, Intradermal; Low-Level Light Therapy; Male; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Psychophysics; Reaction Time; Skin; Time Factors

2003
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:2

    Topics: Analgesics; Animals; Cannabinoids; Capsaicin; Disease Models, Animal; Hyperalgesia; Injections, Intradermal; Male; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2

2004
Capsaicin treatment inhibits osteopenia and heat hyperalgesia induced by chronic constriction injury to the sciatic nerve in rats.
    Hiroshima journal of medical sciences, 2003, Volume: 52, Issue:3

    Topics: Animals; Bone Density; Bone Diseases, Metabolic; Capsaicin; Hot Temperature; Hyperalgesia; Male; Nerve Endings; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P

2003
A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia.
    Anesthesiology, 2003, Volume: 99, Issue:6

    Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Cell Movement; Endocannabinoids; Hyperalgesia; Male; Nerve Growth Factor; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant

2003
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
    Journal of neurophysiology, 2004, Volume: 91, Issue:1

    Topics: Action Potentials; Analysis of Variance; Animals; Capsaicin; Electrophysiology; Evoked Potentials; Histamine; Hot Temperature; Hyperalgesia; Injections, Intradermal; Laminectomy; Macaca fascicularis; Physical Stimulation; Posterior Horn Cells; Pruritus; Reaction Time; Skin; Spinothalamic Tracts; Stimulation, Chemical; Thalamus; Time Factors

2004
Two types of C nociceptors in human skin and their behavior in areas of capsaicin-induced secondary hyperalgesia.
    Journal of neurophysiology, 2004, Volume: 91, Issue:6

    Topics: Action Potentials; Adolescent; Adult; Capsaicin; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Pain Measurement; Reaction Time; Skin

2004
Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2.
    Journal of pharmacological sciences, 2004, Volume: 94, Issue:3

    Topics: Administration, Rectal; Animals; Behavior, Animal; Capsaicin; Colon; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Oligopeptides; Pain; Pain Measurement; Peptides; Receptor, PAR-1; Receptor, PAR-2; Time Factors; Up-Regulation; Viscera

2004
The analgesic effect induced by capsaicin is enhanced in inflammatory states.
    Life sciences, 2004, May-14, Volume: 74, Issue:26

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Disease Models, Animal; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Receptors, Drug; Time Factors

2004
Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors.
    Life sciences, 2004, May-28, Volume: 75, Issue:2

    Topics: Animals; Blotting, Western; Calcium; Capsaicin; Hyperalgesia; Immunohistochemistry; Microscopy, Fluorescence; Nerve Growth Factors; Nociceptors; Rats; Receptors, Drug; Recombinant Proteins; Transfection; TRPV Cation Channels; Tumor Cells, Cultured

2004
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, May-05, Volume: 24, Issue:18

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Enzyme Activators; Enzyme Inhibitors; Humans; Hyperalgesia; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, Drug; RNA, Messenger; Spinal Cord; Substance P; Type C Phospholipases

2004
Presynaptic inhibition and spinal pain processing in mice: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia.
    Neuroscience letters, 2004, May-06, Volume: 361, Issue:1-3

    Topics: Afferent Pathways; Animals; Capsaicin; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Presynaptic Terminals; Reaction Time; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Nerve Roots; Synaptic Transmission

2004
"Nocifensor" system re-revisited. Focus on "Two types of C nociceptor in human skin and their behavior in areas of capaicin-induced secondary hyperalgesia".
    Journal of neurophysiology, 2004, Volume: 91, Issue:6

    Topics: Capsaicin; Humans; Hyperalgesia; Nerve Fibers, Unmyelinated; Nociceptors; Skin

2004
Opioid receptor desensitization contributes to thermal hyperalgesia in infant rats.
    European journal of pharmacology, 2004, May-03, Volume: 491, Issue:2-3

    Topics: Animals; Animals, Newborn; Capsaicin; Dose-Response Relationship, Drug; Female; Hyperalgesia; Morphine; Narcotic Antagonists; Pain Measurement; Pregnancy; Rats; Rats, Long-Evans; Receptors, Opioid; Touch

2004
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interactions; Hyperalgesia; Injections, Intramuscular; Injections, Spinal; Male; Melatonin; Neural Inhibition; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Cord; Spinal Cord Injuries; Tetrahydronaphthalenes; Tryptamines

2004
Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice.
    Cellular and molecular neurobiology, 2004, Volume: 24, Issue:2

    Topics: Animals; Avian Sarcoma Viruses; Capsaicin; Cell Line, Transformed; Cell Line, Tumor; Chronic Disease; Endothelin Receptor Antagonists; Endothelins; Fibroblasts; Genetic Vectors; Hindlimb; Hyperalgesia; Inflammation; Male; Mice; Morphine; Neoplasm Regression, Spontaneous; Neoplasm Transplantation; Nociceptors; Oligopeptides; Pain Measurement; Peptides, Cyclic; Piperidines; Rats; Reaction Time; Receptors, Endothelin

2004
Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin.
    Neuroscience, 2004, Volume: 126, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Capsaicin; Hyperalgesia; Membrane Potentials; Organ Culture Techniques; Rats; Reflex; Spinal Cord; Spinal Nerve Roots

2004
Comparison of hyperalgesia induced by capsaicin injection and controlled heat injury: effect on temporal summation.
    Somatosensory & motor research, 2004, Volume: 21, Issue:1

    Topics: Adult; Capsaicin; Electric Stimulation; Female; Hot Temperature; Humans; Hyperalgesia; Male; Physical Stimulation; Skin

2004
Neural activation during experimental allodynia: a functional magnetic resonance imaging study.
    The European journal of neuroscience, 2004, Volume: 19, Issue:12

    Topics: Adult; Brain Mapping; Capsaicin; Cerebral Cortex; Female; Functional Laterality; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Neurons; Pain; Pain Measurement; Physical Stimulation

2004
Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia.
    Anesthesiology, 2004, Volume: 101, Issue:1

    Topics: Administration, Rectal; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Capsaicin; Colon; Feedback; Foot; Glutamic Acid; Hyperalgesia; Injections; Mice; Mice, Knockout; Pain Measurement; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptosomes

2004
Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.
    Journal of neuroimmunology, 2004, Volume: 153, Issue:1-2

    Topics: Analgesics; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Histamine; Histamine Antagonists; Hyperalgesia; Injections, Spinal; Nerve Growth Factor; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Time Factors; Up-Regulation

2004
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.
    British journal of pharmacology, 2004, Volume: 143, Issue:2

    Topics: Administration, Oral; Animals; Camphanes; Cannabidiol; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hyperalgesia; Inflammation; Italy; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Drug; Rimonabant; Time Factors

2004
Inhibitory effect of capsaicin evoked trigeminal pain on warmth sensation and warmth evoked potentials.
    Experimental brain research, 2005, Volume: 160, Issue:1

    Topics: Adult; Afferent Pathways; Brain; Capsaicin; Electroencephalography; Evoked Potentials, Somatosensory; Female; Functional Laterality; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Nociceptors; Pain; Reaction Time; Thermosensing; Trigeminal Nerve

2005
Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia.
    Pain, 2004, Volume: 111, Issue:3

    Topics: Animals; Capsaicin; Hyperalgesia; Male; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley

2004
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-22, Volume: 24, Issue:38

    Topics: Androstadienes; Animals; Capsaicin; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Ion Channels; Male; Morpholines; Nerve Growth Factor; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Skin; TRPV Cation Channels; Wortmannin

2004
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-22, Volume: 24, Issue:38

    Topics: Animals; Brain-Derived Neurotrophic Factor; Capsaicin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Male; N-Methylaspartate; Nerve Fibers, Unmyelinated; Organ Culture Techniques; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; src-Family Kinases; Stimulation, Chemical; Substance P

2004
Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves.
    Journal of neurochemistry, 2004, Volume: 91, Issue:3

    Topics: Animals; Aspartic Acid; Benzoates; Capsaicin; Dental Pulp; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Imidazoles; Injections, Subcutaneous; Ligation; Lip; Male; Mandibular Nerve; Microdialysis; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Trigeminal Nuclei

2004
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes

2005
In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons.
    Pain, 2004, Volume: 112, Issue:3

    Topics: Animals; Behavior, Animal; Benzylamines; Blotting, Western; Brefeldin A; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Cell Membrane; Cytosol; Drug Interactions; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurons; Physical Stimulation; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Receptors, AMPA; Spinal Cord; Sulfonamides; Time Factors

2004
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3

    Topics: Animals; Brain; Capsaicin; COS Cells; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hydrocarbons, Aromatic; Hyperalgesia; Male; Mice; Nitrogen; Pain; Pyrazoles; Pyridazines; Rats

2005
Acid-induced pain and its modulation in humans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Dec-01, Volume: 24, Issue:48

    Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Female; Forearm; Hot Temperature; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Hyperalgesia; Ibuprofen; Injections, Subcutaneous; Ion Channels; Iontophoresis; Male; Membrane Proteins; Middle Aged; Nerve Tissue Proteins; Pain; Pain Measurement; Pain Threshold; Refractory Period, Electrophysiological; Single-Blind Method; Sodium Channels; TRPV Cation Channels

2004
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Acrylamides; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Humans; Hyperalgesia; Inflammation; Motor Activity; Neurons; Pain Measurement; Patch-Clamp Techniques; Protons; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Transfection

2005
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia.
    Pain, 2005, Volume: 113, Issue:1-2

    Topics: Animals; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Enzyme Activation; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Ion Channels; Male; Mitogen-Activated Protein Kinase 6; Neurofilament Proteins; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; TRPV Cation Channels

2005
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Mar-22, Volume: 102, Issue:12

    Topics: Animals; Arachidonic Acids; Calcium Signaling; Capsaicin; Cell Line; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Endocannabinoids; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; Inflammation Mediators; Ion Channel Gating; Ion Channels; Macrophage Inflammatory Proteins; Mice; Mice, Inbred BALB C; Neurons; Polyunsaturated Alkamides; Rats; Receptors, CCR1; Receptors, Chemokine; Transfection; TRPV Cation Channels

2005
Vasomotor response to cold stimulation in human capsaicin-induced hyperalgesic area.
    Experimental brain research, 2005, Volume: 164, Issue:3

    Topics: Adult; Analysis of Variance; Capsaicin; Cold Temperature; Female; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Pain Measurement; Skin; Skin Temperature; Time Factors; Vasoconstriction; Vasodilation

2005
A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging.
    Pain, 2005, Volume: 114, Issue:3

    Topics: Acute Disease; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Medulla Oblongata; Psychophysics; Reticular Formation

2005
Selective ablation of nociceptive neurons for elimination of hyperalgesia and neurogenic inflammation.
    Journal of neurosurgery, 2005, Volume: 102, Issue:3

    Topics: Animals; Capsaicin; Diterpenes; Hyperalgesia; Immunohistochemistry; Macaca mulatta; Neurogenic Inflammation; Neurons, Afferent; Nociceptors; Trigeminal Ganglion

2005
Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse.
    Pain, 2005, Volume: 115, Issue:1-2

    Topics: Animals; Capsaicin; Cells, Cultured; Freund's Adjuvant; Glycoproteins; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Ion Channels; Men; Mice; Mice, Inbred C57BL; Nociceptors; TRPV Cation Channels

2005
Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats.
    Neuroscience, 2005, Volume: 132, Issue:3

    Topics: Action Potentials; Alanine; Animals; Capsaicin; Drug Interactions; Edema; Extremities; GABA Plasma Membrane Transport Proteins; Hyperalgesia; Injections, Intradermal; Laminectomy; Male; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Fibers, Unmyelinated; Neural Conduction; Neural Inhibition; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Nerve Roots; Time Factors

2005
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relationship, Drug; Edema; Formaldehyde; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Isoquinolines; Ligation; Male; Motor Activity; Osteoarthritis; Pain; Pain Measurement; Pain, Postoperative; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sciatic Nerve; Spinal Nerves; Urea

2005
Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.
    Croatian medical journal, 2005, Volume: 46, Issue:2

    Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Carrageenan; Hindlimb; Hyperalgesia; Male; Models, Animal; Nociceptors; Pain; Rats; Rats, Wistar

2005
Painful stimuli induce in vivo phosphorylation and membrane mobilization of mouse spinal cord NKCC1 co-transporter.
    Neuroscience, 2005, Volume: 133, Issue:1

    Topics: Animals; Blotting, Western; Capsaicin; Cell Membrane; Cytosol; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Neural Pathways; Pain; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Cord; Subcellular Fractions

2005
Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse.
    Brain research, 2005, Aug-02, Volume: 1052, Issue:1

    Topics: Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain Measurement; Physical Stimulation; Reaction Time; Receptors, Dopamine D2

2005
Heat and mechanical hyperalgesia in mice model of cancer pain.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Animals; Body Temperature; Capsaicin; Cell Count; Cell Line, Tumor; Cell Size; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Humans; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Pain; Pain Measurement; Pain Threshold; Reaction Time; Staining and Labeling; Time Factors; TRPV Cation Channels

2005
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats.
    The European journal of neuroscience, 2005, Volume: 22, Issue:2

    Topics: Action Potentials; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Camphanes; Cannabinoids; Capsaicin; Cells, Cultured; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Neural Inhibition; Neurons; Pain Measurement; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord Diseases; Touch

2005
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
    European journal of pharmacology, 2005, Sep-20, Volume: 519, Issue:3

    Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glycine; Hindlimb; Hyperalgesia; Indans; Male; Pain; Rats; Rats, Sprague-Dawley

2005
Co-activation of P2Y2 receptor and TRPV channel by ATP: implications for ATP induced pain.
    Cellular and molecular neurobiology, 2005, Volume: 25, Issue:5

    Topics: Adenosine Triphosphate; Animals; Calcium; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Hyperalgesia; Ion Channels; Mice; Neurons; Pain; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; TRPV Cation Channels

2005
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
    Pain, 2005, Volume: 117, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area Under Curve; Blotting, Western; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Pain; Pain Measurement; Phosphorylation; Physical Stimulation; Protein Kinase C; Rats; Receptors, AMPA; Serine; Spider Venoms; Spinal Cord

2005
TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues.
    Brain research bulletin, 2005, Nov-30, Volume: 67, Issue:6

    Topics: Adjuvants, Immunologic; Analgesics; Animals; Capsaicin; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Pain; Pain Measurement; TRPV Cation Channels

2005
Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2006, Volume: 13, Issue:3

    Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Enkephalins; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Hyperalgesia; Macaca; Morphine; Nociceptors; Reaction Time; Simplexvirus; Skin

2006
Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene.
    Neuroscience, 2006, Volume: 137, Issue:2

    Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Ganglia, Spinal; Heterozygote; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factor; Neuralgia; Neurofibromatosis 1; Neurons, Afferent; Neuropeptides; Organ Culture Techniques; Pain Threshold; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins p21(ras); Substance P; Synaptic Transmission

2006
Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study.
    The journal of pain, 2005, Volume: 6, Issue:12

    Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Capsaicin; Chronic Disease; Complex Regional Pain Syndromes; Critical Period, Psychological; Disease Models, Animal; Foot; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Nerve Fibers, Unmyelinated; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Up-Regulation

2005
Effects of cold stimulation on secondary hyperalgesia (HA) induced by capsaicin in healthy volunteers.
    Experimental brain research, 2006, Volume: 170, Issue:1

    Topics: Adult; Capsaicin; Cold Temperature; Elbow; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Nerve Fibers, Myelinated; Pain Measurement; Photic Stimulation; Physical Stimulation; Pilot Projects; Wrist

2006
Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin.
    Pain, 2006, Volume: 120, Issue:1-2

    Topics: Animals; Capsaicin; Cells, Cultured; Enzyme Activation; Hyperalgesia; Male; Posterior Horn Cells; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Touch

2006
Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons.
    Journal of neurophysiology, 2006, Volume: 95, Issue:2

    Topics: Animals; Capsaicin; Cells, Cultured; Cold Temperature; Dose-Response Relationship, Drug; Hyperalgesia; Menthol; Neurons, Afferent; Nociceptors; Pain Threshold; Posterior Horn Cells; Rats; Sensitivity and Specificity; Tissue Distribution; TRPM Cation Channels

2006
Gender differences in pain and secondary hyperalgesia after heat/capsaicin sensitization in healthy volunteers.
    The journal of pain, 2006, Volume: 7, Issue:3

    Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Reference Values; Sex Factors

2006
CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms.
    The European journal of neuroscience, 2006, Volume: 23, Issue:6

    Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; DNA Primers; DNA, Complementary; Formaldehyde; Hyperalgesia; Ligation; Male; Mice; Microglia; Nervous System Physiological Phenomena; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sciatic Nerve; Spinal Cord; Spinal Nerves; Transcription, Genetic

2006
Pivotal involvement of neurogenic mechanism in subcutaneous bee venom-induced inflammation and allodynia in unanesthetized conscious rats.
    Experimental neurology, 2006, Volume: 200, Issue:2

    Topics: Analysis of Variance; Animals; Bee Venoms; Behavior, Animal; Capsaicin; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Rhizotomy; Sciatic Nerve; Touch; Wakefulness

2006
Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin.
    Neuroscience letters, 2006, Jul-10, Volume: 402, Issue:1-2

    Topics: Animals; Bradykinin; Capsaicin; Colon; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Pain Measurement; Receptor, PAR-2; Time Factors; Trypsin

2006
Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay.
    Behavioural brain research, 2006, Jun-30, Volume: 170, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Conditioning, Operant; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley

2006
The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization.
    Pain, 2006, Volume: 122, Issue:3

    Topics: Adult; Botulinum Toxins, Type A; Capsaicin; Face; Forehead; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Pressure; Regional Blood Flow; Skin Temperature; Trigeminal Nerve; Urticaria

2006
Heat/burning sensation induced by topical application of capsaicin on perineal cutaneous area: new approach in diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome?
    Urology, 2006, Volume: 67, Issue:5

    Topics: Administration, Topical; Adult; Analgesics, Non-Narcotic; Capsaicin; Chronic Disease; Feasibility Studies; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Unmyelinated; Nociceptors; Pain Measurement; Pelvic Pain; Perineum; Prostatitis; Treatment Outcome

2006
Increased pain sensitivity to intraoral capsaicin in patients with atypical odontalgia.
    Journal of orofacial pain, 2006,Spring, Volume: 20, Issue:2

    Topics: Analysis of Variance; Capsaicin; Case-Control Studies; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Pain Threshold; Sensitivity and Specificity; Toothache; Trigeminal Nerve

2006
Role of the Na+-K+-2Cl- cotransporter in the development of capsaicin-induced neurogenic inflammation.
    Journal of neurophysiology, 2006, Volume: 95, Issue:6

    Topics: Animals; Bumetanide; Capsaicin; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Rats; Rats, Sprague-Dawley; Reflex; Sodium-Potassium-Chloride Symporters; Vasodilation

2006
Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.
    Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12

    Topics: Administration, Oral; Analgesics; Animals; Benzimidazoles; Biological Availability; Calcium; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Freund's Adjuvant; Hot Temperature; Hydrogen-Ion Concentration; Hyperalgesia; Male; Pain Measurement; Piperazines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; TRPV Cation Channels

2006
Chronic nerve growth factor administration increases the peripheral exocytotic activity of capsaicin-sensitive cutaneous neurons.
    Neuroscience letters, 2006, Aug-07, Volume: 403, Issue:3

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Exocytosis; Hot Temperature; Hyperalgesia; In Vitro Techniques; Injections, Subcutaneous; Male; Nerve Endings; Nerve Growth Factor; Neurogenic Inflammation; Neurons; Rats; Rats, Sprague-Dawley; Skin

2006
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jun-21, Volume: 26, Issue:25

    Topics: Animals; Behavior, Animal; Body Temperature; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Gastrointestinal Hormones; Gene Expression Regulation; Hyperalgesia; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; TRPV Cation Channels

2006
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
    The Journal of physiology, 2006, Sep-01, Volume: 575, Issue:Pt 2

    Topics: Animals; Calcium Signaling; Capsaicin; Cell Line; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Ganglia, Spinal; Gene Expression Regulation, Enzymologic; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; TRPV Cation Channels

2006
Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.
    Neuropharmacology, 2006, Volume: 51, Issue:3

    Topics: Analysis of Variance; Animals; Benzothiazoles; Brain; Capsaicin; Drug Synergism; Ganglia, Spinal; Histamine H2 Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Pain Measurement; Phenoxypropanolamines; Piperidines; Reaction Time; Receptors, Histamine H2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Touch

2006
Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:1

    Topics: Analgesics; Animals; Capsaicin; Carrageenan; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid

2006
Capsaicin-evoked brain activation and central sensitization in anaesthetised rats: a functional magnetic resonance imaging study.
    Pain, 2006, Dec-15, Volume: 126, Issue:1-3

    Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Capsaicin; Hyperalgesia; Injections, Intradermal; Magnetic Resonance Imaging; Mesencephalon; Ointments; Oxygen; Pain; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Superior Colliculi; Thalamus; Time Factors

2006
Differential responses of rostral subnucleus caudalis and upper cervical dorsal horn neurons to mechanical and chemical stimulation of the parotid gland in rats.
    Brain research, 2006, Aug-23, Volume: 1106, Issue:1

    Topics: Action Potentials; Afferent Pathways; Animals; Capsaicin; Cervical Vertebrae; Cold Temperature; Hyperalgesia; Inflammation Mediators; Male; Nociceptors; Pain; Pain Measurement; Pain Threshold; Parotid Gland; Parotitis; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Skin; Trigeminal Caudal Nucleus

2006
Assessing mechanical sensitivity of masseter muscle in lightly anesthetized rats: a model for craniofacial muscle hyperalgesia.
    Neuroscience research, 2006, Volume: 56, Issue:1

    Topics: Analgesics, Non-Narcotic; Anesthesia; Animals; Behavior; Bradykinin; Capsaicin; Facial Pain; Glutamic Acid; Humans; Hyperalgesia; Male; Masseter Muscle; Models, Biological; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley

2006
Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons.
    The Journal of physiology, 2006, Nov-01, Volume: 576, Issue:Pt 3

    Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Cells, Cultured; Female; Gene Expression Regulation; Hyperalgesia; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Protein Kinases; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; RNA, Messenger; Second Messenger Systems; Serotonin; Serotonin Agents; Synapses; TRPV Cation Channels

2006
Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Aug-16, Volume: 26, Issue:33

    Topics: Animals; Capsaicin; Cells, Cultured; Drug Synergism; Ganglia, Spinal; Glial Cell Line-Derived Neurotrophic Factor; Growth Substances; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Multigene Family; Nerve Growth Factor; Nerve Tissue Proteins; Neurons, Afferent; Neurturin; Nociceptors; Receptors, Cell Surface; Skin; Time Factors; Tissue Distribution; TRPV Cation Channels

2006
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels

2006
Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:3

    Topics: Animals; Biphenyl Compounds; Blotting, Western; Capsaicin; Cells, Cultured; Dinoprostone; Electrophysiology; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Hybridization; Inflammation; Injections, Spinal; Male; Neurons; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Small Interfering

2006
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Sep-13, Volume: 26, Issue:37

    Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Cultured; Central Nervous System; Disease Models, Animal; Humans; Hyperalgesia; Indazoles; Inflammation Mediators; Injections, Spinal; Male; Nociceptors; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Sulfones; Treatment Outcome; TRPV Cation Channels; Urea

2006
Intradermal capsaicin causes dose-dependent pain, allodynia, and hyperalgesia in humans.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2006, Volume: 54, Issue:5

    Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain

2006
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli.
    Pain, 2007, Volume: 129, Issue:1-2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Drug Interactions; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Time Factors; Vibration

2007
The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.
    European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3

    Topics: Administration, Oral; Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabis; Capsaicin; Chronic Disease; Dinoprostone; Freund's Adjuvant; Hyperalgesia; Inflammation; Lipid Peroxides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Sciatic Neuropathy; Tumor Necrosis Factor-alpha

2007
Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia.
    Pain, 2007, Volume: 130, Issue:1-2

    Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; Avoidance Learning; Capsaicin; Carbolines; Catheterization; Colon; Electromyography; Gastrointestinal Agents; Hyperalgesia; Irritable Bowel Syndrome; Male; Nociceptors; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Rectum; Stress, Psychological; Vagotomy; Vagus Nerve; Visceral Afferents

2007
The role of uninjured C-afferents and injured afferents in the generation of mechanical hypersensitivity after partial peripheral nerve injury in the rat.
    Experimental neurology, 2007, Volume: 204, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Ganglia, Spinal; Hyperalgesia; Ligation; Lumbosacral Region; Male; Nerve Fibers, Unmyelinated; Nervous System Diseases; Neural Conduction; Neurons, Afferent; Nociceptors; Rats; Rats, Sprague-Dawley; Rhizotomy; Sciatic Nerve; Spinal Nerves; Time Factors

2007
Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: a systematic comparative study in conscious rats.
    Experimental neurology, 2007, Volume: 204, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Bee Venoms; Behavior, Animal; Capsaicin; Carrageenan; Edema; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Irritants; Male; Neuralgia; Neuritis; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time

2007
Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats.
    Psychopharmacology, 2007, Volume: 191, Issue:2

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Inflammation; Injections, Intraventricular; Injections, Subcutaneous; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid; Sex Factors

2007
Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:1

    Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Cold Temperature; Enzyme Activation; Hot Temperature; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Male; Mitogen-Activated Protein Kinase 6; Neurons, Afferent; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; RNA, Antisense; Signal Transduction; TRPV Cation Channels

2007
The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
    Gastroenterology, 2007, Volume: 132, Issue:2

    Topics: Acetic Acid; Age Factors; Anilides; Animals; Animals, Newborn; Capsaicin; Catheterization; Cinnamates; Colon; Disease Models, Animal; Diterpenes; Electromyography; Ganglia, Spinal; Hyperalgesia; Irritable Bowel Syndrome; Male; Pain; Rats; Rats, Sprague-Dawley; Reflex, Abdominal; TRPV Cation Channels; Visceral Afferents

2007
Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain.
    Pain, 2007, Volume: 131, Issue:3

    Topics: Animals; Capsaicin; Disease Models, Animal; Hyperalgesia; Male; Pain; Pain Threshold; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate

2007
The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons.
    Pain, 2007, Dec-15, Volume: 133, Issue:1-3

    Topics: Action Potentials; Analysis of Variance; Animals; Antioxidants; Behavior, Animal; Capsaicin; Cyclic N-Oxides; Disease Models, Animal; Drug Interactions; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spin Labels; Time Factors

2007
Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study.
    NeuroImage, 2007, May-01, Volume: 35, Issue:4

    Topics: Administration, Topical; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Individuality; Logistic Models; Magnetic Resonance Imaging; Male; Neural Pathways; Nociceptors; Pain Measurement; Physical Stimulation; Positron-Emission Tomography; Psychophysics; Synaptic Transmission; Trigeminal Nerve

2007
Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked pain.
    The journal of pain, 2007, Volume: 8, Issue:6

    Topics: Adult; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Humans; Hyperalgesia; Inflammation Mediators; Laser-Doppler Flowmetry; Male; Middle Aged; Models, Neurological; Nerve Fibers, Unmyelinated; Neuronal Plasticity; Neurosecretory Systems; Nociceptors; Pain; Pain Measurement; Psychophysics; Regional Blood Flow; Sensory Receptor Cells; Skin; Time Factors

2007
A role for peripheral afferents in the pathophysiology and treatment of at-level neuropathic pain in spinal cord injury? A case report.
    Pain, 2007, Volume: 131, Issue:1-2

    Topics: Administration, Topical; Afferent Pathways; Capsaicin; Humans; Hyperalgesia; Lidocaine; Male; Middle Aged; Spinal Fractures; Thoracic Vertebrae

2007
The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level.
    Pain, 2008, Volume: 134, Issue:3

    Topics: Analgesics; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Hyperalgesia; Injections, Spinal; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spinal Cord; TRPV Cation Channels

2008
Static magnetic field-induced anti-nociceptive effect and the involvement of capsaicin-sensitive sensory nerves in this mechanism.
    Life sciences, 2007, Jun-20, Volume: 81, Issue:2

    Topics: Analgesia; Animals; Capsaicin; Carrageenan; Chemoreceptor Cells; Diterpenes; Electromagnetic Fields; Formaldehyde; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Nerve Fibers; Neurons, Afferent; Pain Measurement; Postural Balance

2007
Painful nerve injury shortens the intracellular Ca2+ signal in axotomized sensory neurons of rats.
    Anesthesiology, 2007, Volume: 107, Issue:1

    Topics: Animals; Axotomy; Calcium Signaling; Capsaicin; Cell Size; Cytophotometry; Electric Stimulation; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Nerve Fibers; Neurons, Afferent; Nociceptors; Peripheral Nerve Injuries; Potassium; Rats; Rats, Sprague-Dawley; Spinal Nerves; Stimulation, Chemical; Wallerian Degeneration

2007
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
    The Journal of biological chemistry, 2007, Sep-07, Volume: 282, Issue:36

    Topics: Animals; Aprotinin; Calcium Signaling; Capsaicin; Edema; Enteropeptidase; Ganglia, Spinal; Granulocytes; Humans; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptor, PAR-2; Receptors, Proteinase-Activated; Receptors, Thrombin; Recombinant Proteins; Trypsin; Trypsin Inhibitors

2007
Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:4

    Topics: Animals; Behavior, Animal; Capsaicin; Colitis; Colon; Dextran Sulfate; Female; Hyperalgesia; Mice; Mice, Inbred C57BL; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Spinal Cord; TRPV Cation Channels

2007
Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis.
    Gastroenterology, 2007, Volume: 133, Issue:4

    Topics: Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; Hyperalgesia; Male; Membrane Potentials; Pain Measurement; Pain Threshold; Pancreas; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Up-Regulation

2007
The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis.
    Neuroscience, 2007, Sep-21, Volume: 148, Issue:4

    Topics: Animals; Capsaicin; Colitis; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Electromyography; Ganglia, Spinal; Gastrointestinal Motility; Hyperalgesia; Male; Neurons; Rats; Rats, Sprague-Dawley; Reflex, Abdominal; Sulfonamides; Thiourea; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Visceral Afferents

2007
Depletion of capsaicin-sensitive afferents prevents lamina-dependent increases in spinal N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats.
    European journal of pain (London, England), 2008, Volume: 12, Issue:5

    Topics: Afferent Pathways; Animals; Capsaicin; Diterpenes; Hot Temperature; Hyperalgesia; Ligation; Male; Perception; Phosphorylation; Posterior Horn Cells; Pressure; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy; Spinal Cord; Time Factors; TRPV Cation Channels; Up-Regulation

2008
Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity.
    Brain research, 2007, Dec-12, Volume: 1184

    Topics: Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hyperalgesia; Male; Masseter Muscle; Methylene Blue; Mice; Nerve Tissue Proteins; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sensory Thresholds; Soluble Guanylyl Cyclase; Time Factors; Trigeminal Caudal Nucleus

2007
Nociceptive tuning by stem cell factor/c-Kit signaling.
    Neuron, 2007, Dec-06, Volume: 56, Issue:5

    Topics: Animals; Calcium; Capsaicin; Cell Count; Electrophysiology; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Mechanoreceptors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron; Mutation; Neurons, Afferent; Nociceptors; Pain Measurement; Patch-Clamp Techniques; Proto-Oncogene Proteins c-kit; Signal Transduction; Skin; Stem Cell Factor; TRPV Cation Channels

2007
TRPM8 mechanism of cold allodynia after chronic nerve injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Dec-12, Volume: 27, Issue:50

    Topics: Animals; Capsaicin; Cells, Cultured; Chronic Disease; Cold Temperature; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Menthol; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Skin; TRPM Cation Channels

2007
The role of capsaicin-sensitive primary afferents in experimental sciatica induced by disc herniation in rats.
    Spine, 2008, Jan-15, Volume: 33, Issue:2

    Topics: Administration, Topical; Animals; Capsaicin; Cell Count; Disease Models, Animal; Hot Temperature; Hyperalgesia; Immunoenzyme Techniques; Intervertebral Disc Displacement; Nerve Compression Syndromes; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sciatica; Sensory System Agents; Spinal Cord

2008
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia.
    Molecular pain, 2008, Jan-16, Volume: 4

    Topics: Administration, Cutaneous; Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Edema; Electric Stimulation; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurogenic Inflammation; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Sciatic Nerve; Time Factors; TRPV Cation Channels

2008
Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy.
    Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:2

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Catechols; Disease Models, Animal; Diterpenes; Drug Interactions; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nerve Fibers, Unmyelinated; Nerve Regeneration; Neural Conduction; Neuroprotective Agents; Peripheral Nervous System Diseases; Reaction Time; Skin; Substance P; Ubiquitin Thiolesterase

2008
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:2

    Topics: Acute Disease; Analgesics, Opioid; Animals; Capsaicin; Data Interpretation, Statistical; Dextromethorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hot Temperature; Hyperalgesia; Male; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Inbred F344; Sex Characteristics

2008
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
    PLoS biology, 2008, Volume: 6, Issue:1

    Topics: Acids; Animals; Capsaicin; Hyperalgesia; Inflammation; Mole Rats; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells

2008
Local application of capsaicin alleviates mechanical hyperalgesia after spinal nerve transection.
    Neuroscience letters, 2008, Mar-15, Volume: 433, Issue:3

    Topics: Analgesics; Animals; Biomarkers; Calcitonin Gene-Related Peptide; Capsaicin; Cell Count; Denervation; Ganglia, Spinal; Hyperalgesia; Male; Nerve Degeneration; Neuralgia; Neurons, Afferent; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels

2008
Leukemia inhibitory factor differentially regulates capsaicin and heat sensitivity in cultured rat dorsal root ganglion neurons.
    Neuropeptides, 2008, Volume: 42, Issue:2

    Topics: Animals; Capsaicin; Cells, Cultured; Galanin; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Leukemia Inhibitory Factor; Male; Nerve Growth Factor; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels

2008
Dissociable neural activity to self- vs. externally administered thermal hyperalgesia: a parametric fMRI study.
    The European journal of neuroscience, 2008, Volume: 27, Issue:3

    Topics: Adaptation, Psychological; Adult; Brain; Brain Mapping; Capsaicin; Cerebral Cortex; Chronic Disease; Cognition; Data Interpretation, Statistical; Functional Laterality; Gyrus Cinguli; Hot Temperature; Humans; Hyperalgesia; Limbic System; Magnetic Resonance Imaging; Male; Neurons; Neuropsychological Tests; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Self Administration; Somatosensory Cortex

2008
Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice.
    Pain, 2008, Sep-15, Volume: 138, Issue:3

    Topics: Animals; Capsaicin; Free Radical Scavengers; Hyperalgesia; Male; Mice; Oxidative Stress; Pain Measurement; Physical Stimulation; Spinal Cord; Touch

2008
NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin.
    Pain, 2008, Sep-30, Volume: 139, Issue:1

    Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Lidocaine; Male; Medulla Oblongata; Microinjections; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pilot Projects; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1

2008
Fire in the hole: pore dilation of the capsaicin receptor TRPV1.
    Nature neuroscience, 2008, Volume: 11, Issue:5

    Topics: Animals; Capsaicin; Cell Membrane Permeability; Humans; Hyperalgesia; Inflammation Mediators; Ion Channel Gating; Ions; Models, Molecular; Neurogenic Inflammation; Nociceptors; Pain; Sensory Receptor Cells; Sensory System Agents; Signal Transduction; TRPV Cation Channels

2008
Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain.
    The journal of pain, 2008, Volume: 9, Issue:8

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Foot Diseases; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Neoplasms, Experimental; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Inbred F344; Ruthenium Red; TRPV Cation Channels

2008
Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, May-07, Volume: 28, Issue:19

    Topics: Animals; Capsaicin; Carcinoma; Cells, Cultured; Etanercept; Gene Deletion; Hindlimb; Hot Temperature; Hyperalgesia; Immunoglobulin G; Mice; Neoplasm Transplantation; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation

2008
Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia.
    Neuroscience, 2008, Jun-26, Volume: 154, Issue:3

    Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Cell Line; Electrophysiology; Endothelin-1; Hot Temperature; Humans; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Reaction Time; Receptor, Endothelin A; TRPV Cation Channels

2008
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision.
    Anesthesiology, 2008, Volume: 108, Issue:6

    Topics: Acrylamides; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Male; Morphine; Pain, Postoperative; Physical Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels

2008
Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin.
    Pain, 1995, Volume: 60, Issue:3

    Topics: Adolescent; Adult; Capsaicin; Drug Eruptions; Female; Hot Temperature; Humans; Hyperalgesia; Male; Norepinephrine; Pain Threshold; Regional Blood Flow; Skin; Sympathetic Nervous System; Vasomotor System

1995
Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat.
    Neuroscience, 1995, Volume: 65, Issue:1

    Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Male; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley; Sympathetic Fibers, Postganglionic

1995
Sensitization of insensitive branches of C nociceptors in human skin.
    The Journal of physiology, 1994, Oct-15, Volume: 480 ( Pt 2)

    Topics: Adult; Capsaicin; Electric Stimulation; Electrophysiology; Humans; Hyperalgesia; Inflammation; Male; Mechanoreceptors; Mustard Plant; Nociceptors; Plant Extracts; Plant Oils; Skin

1994
Inflammation and hyperalgesia in rats neonatally treated with capsaicin: effects on two classes of nociceptive neurons in the superficial dorsal horn.
    Pain, 1994, Volume: 59, Issue:2

    Topics: Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Electric Stimulation; Female; Freund's Adjuvant; Hyperalgesia; Immunohistochemistry; Inflammation; Microscopy, Electron; Nerve Fibers; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord

1994
Different patterns of hyperalgesia induced by experimental inflammation in human skin.
    Brain : a journal of neurology, 1994, Volume: 117 ( Pt 2)

    Topics: Adult; Capsaicin; Dermatitis; Female; Freezing; Humans; Hyperalgesia; Male; Middle Aged; Pain; Physical Stimulation; Sensation; Sensory Thresholds; Skin

1994
Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation.
    Neuroscience, 1994, Volume: 58, Issue:4

    Topics: Amino Acid Sequence; Animals; Capsaicin; Depression, Chemical; Electric Stimulation; Foot; Hyperalgesia; Male; Molecular Sequence Data; Naloxone; Narcotics; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Skin; Ultraviolet Rays

1994
The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat.
    Agents and actions, 1993, Volume: 38 Spec No

    Topics: Animals; Arthritis, Experimental; Capsaicin; Disease Models, Animal; Enflurane; Female; Freund's Adjuvant; Hyperalgesia; Rats; Rats, Sprague-Dawley; Uric Acid

1993
Topical capsaicin in treatment of hyperalgesia, allodynia and dysesthetic pain caused by malignant tumour infiltration of the skin.
    Acta oncologica (Stockholm, Sweden), 1993, Volume: 32, Issue:3

    Topics: Administration, Topical; Adult; Capsaicin; Humans; Hyperalgesia; Male; Pain; Skin Neoplasms

1993
Dissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy.
    Pain, 1993, Volume: 53, Issue:2

    Topics: Adult; Capsaicin; Evoked Potentials; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Mechanoreceptors; Nerve Fibers; Neurons, Afferent; Nociceptors; Peripheral Nervous System Diseases

1993
Facilitation of the human nociceptive reflex by stimulation of A beta-fibres in a secondary hyperalgesic area sustained by nociceptive input from the primary hyperalgesic area.
    Acta physiologica Scandinavica, 1995, Volume: 155, Issue:1

    Topics: Adrenergic Fibers; Adult; Analysis of Variance; Capsaicin; Foot; Humans; Hyperalgesia; Pain Measurement; Pain Threshold; Reflex

1995
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Feb-06, Volume: 93, Issue:3

    Topics: Adenosine; Animals; Capsaicin; Cells, Cultured; Dinoprostone; Ganglia, Spinal; Hyperalgesia; Kinetics; Male; Membrane Potentials; Neurons; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Serotonin; Sodium Channels; Tetrodotoxin; Thromboxane B2

1996
Cutaneous pretreatment with the capsaicin analog NE-21610 prevents the pain to a burn and subsequent hyperalgesia.
    Pain, 1995, Volume: 62, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Burns; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Pain; Pain Measurement; Physical Stimulation; Skin

1995
Brief, prolonged and repeated stimuli applied to hyperalgesic skin areas: a psychophysical study.
    Brain research, 1996, Mar-11, Volume: 712, Issue:1

    Topics: Capsaicin; Electric Stimulation; Hot Temperature; Humans; Hyperalgesia; Lasers; Pain; Pain Threshold; Psychophysics; Skin

1996
Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism.
    Anesthesiology, 1996, Volume: 85, Issue:3

    Topics: Adult; Capsaicin; Humans; Hyperalgesia; Middle Aged; Nerve Block; Nerve Fibers; Pain; Spinal Cord

1996
Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors.
    British journal of pharmacology, 1996, Volume: 118, Issue:8

    Topics: Animals; Capsaicin; Female; Hyperalgesia; Knee Joint; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Substance P

1996
Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats.
    Pain, 1996, Volume: 67, Issue:1

    Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Foot; Hot Temperature; Hyperalgesia; Injections; Male; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex

1996
Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats.
    Pain, 1997, Volume: 71, Issue:2

    Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Capsaicin; Hyperalgesia; Injections, Intradermal; Male; Microdialysis; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Pain; Pain Threshold; Peptides; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spider Venoms

1997
Capsaicin-evoked mechanical allodynia and hyperalgesia cross-nerve territories.
    Anesthesiology, 1997, Volume: 87, Issue:2

    Topics: Capsaicin; Humans; Hyperalgesia; Pain; Pharmaceutical Vehicles

1997
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
    Science (New York, N.Y.), 1997, Oct-10, Volume: 278, Issue:5336

    Topics: Animals; Capsaicin; Cell Membrane; Cells, Cultured; Fluorescent Antibody Technique; Hyperalgesia; Immunotoxins; Injections, Spinal; N-Glycosyl Hydrolases; Neurons; Pain; Pain Management; Pain Measurement; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P

1997
Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex.
    Brain research bulletin, 1997, Volume: 44, Issue:3

    Topics: Animals; Capsaicin; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Ganglia, Spinal; Hindlimb; Hot Temperature; Hyperalgesia; Immersion; Male; Mechanoreceptors; Nerve Fibers; Nerve Regeneration; Neuralgia; Neurites; Neurons, Afferent; Nociceptors; Physical Stimulation; Plasma; Rats; Rats, Wistar; Reflex; Sciatic Nerve

1997
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Capsaicin; Electric Stimulation; Endocytosis; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Long-Term Potentiation; Male; Microscopy, Confocal; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P

1997
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21

    Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Hypesthesia; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Nerve Growth Factors; Neurotrophin 3; Organophosphorus Compounds; Pain; Pain Threshold; Perfusion; Pressure; Rats; Rats, Wistar; Secretory Rate; Single-Blind Method; Spinal Cord; Substance P

1997
Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist.
    British journal of pharmacology, 1997, Volume: 122, Issue:5

    Topics: Analgesics, Non-Narcotic; Animals; Brain; Capsaicin; Carrageenan; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Subcutaneous; Male; Motor Activity; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetradecanoylphorbol Acetate

1997
Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin.
    British journal of pharmacology, 1997, Volume: 122, Issue:6

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Animals; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hyperalgesia; Injections, Intradermal; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord

1997
Postnatal NGF administration causes adult hyperalgesia and overreactivity to social stimuli but does not reverse capsaicin induced hypoalgesia.
    Psychoneuroendocrinology, 1997, Volume: 22, Issue:8

    Topics: Aggression; Animals; Animals, Newborn; Capsaicin; Female; Hot Temperature; Hyperalgesia; Male; Mice; Nerve Growth Factors; Pain Measurement; Social Behavior

1997
Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans.
    Pain, 1998, Volume: 74, Issue:2-3

    Topics: Adolescent; Adult; Capsaicin; Conditioning, Psychological; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Nociceptors; Pain Threshold; Perception; Synapses; Touch

1998
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors.
    Pain, 1998, Volume: 75, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Carrageenan; Edema; Endocannabinoids; Hindlimb; Hyperalgesia; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Skin

1998
Nitric oxide contributes to central sensitization following intradermal injection of capsaicin.
    Neuroreport, 1998, Mar-09, Volume: 9, Issue:4

    Topics: Analysis of Variance; Animals; Capsaicin; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Spinal Cord

1998
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
    European journal of pharmacology, 1998, Mar-26, Volume: 345, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord

1998
The effect of noradrenaline, angiotensin II and vasopressin on blood flow and sensitivity to heat in capsaicin-treated skin.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1998, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Angiotensin II; Capsaicin; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Norepinephrine; Regional Blood Flow; Skin; Vasoconstrictor Agents; Vasopressins

1998
Enhancement of thermal hyperalgesia by alpha-adrenoceptors in capsaicin-treated skin.
    Journal of the autonomic nervous system, 1998, Apr-30, Volume: 69, Issue:2-3

    Topics: Administration, Topical; Adolescent; Adrenergic alpha-Antagonists; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Norepinephrine; Pain Threshold; Phenoxybenzamine; Receptors, Adrenergic, alpha; Skin; Sympathomimetics; Tyramine

1998
Effects of endothelin-1 on capsaicin-induced nociception in mice.
    European journal of pharmacology, 1998, Jun-12, Volume: 351, Issue:1

    Topics: Analgesia; Animals; Bosentan; Capsaicin; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hindlimb; Hyperalgesia; Male; Mice; Oligopeptides; Peptide Fragments; Peptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Serotonin; Sulfonamides; Viper Venoms

1998
Increased capsaicin-induced secondary hyperalgesia as a marker of abnormal sensory activity in patients with fibromyalgia.
    Neuroscience letters, 1998, Jul-10, Volume: 250, Issue:3

    Topics: Biomarkers; Capsaicin; Female; Fibromyalgia; Ganglia, Sensory; Humans; Hyperalgesia; Male; Middle Aged

1998
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
    Life sciences, 1998, Volume: 63, Issue:5

    Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Substance P; Zymosan

1998
Differential effect of painful heterotopic stimulation on capsaicin-induced pain and allodynia.
    Brain research, 1998, Aug-10, Volume: 801, Issue:1-2

    Topics: Adult; Capsaicin; Cold Temperature; Differential Threshold; Humans; Hyperalgesia; Injections, Subcutaneous; Male; Models, Neurological; Pain; Pain Measurement; Physical Stimulation; Spinal Cord; Time Factors

1998
Transient inhibition of responses to thermal stimuli of spinal sensory tract neurons in monkeys during sensitization by intradermal capsaicin.
    Pain, 1998, Volume: 77, Issue:2

    Topics: Animals; Capsaicin; Female; Hot Temperature; Hyperalgesia; Injections, Intradermal; Macaca fascicularis; Male; Neurons, Afferent; Physical Stimulation; Spinothalamic Tracts

1998
Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.
    Pain, 1998, Volume: 78, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclooxygenase Inhibitors; Freund's Adjuvant; Hyperalgesia; Ibuprofen; In Vitro Techniques; Injections, Spinal; Ketorolac; Male; Myelitis; Neuropeptides; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tolmetin

1998
Region-specific increase in glutamate release from dorsal horn of rats with adjuvant inflammation.
    Neuroreport, 1998, Oct-05, Volume: 9, Issue:14

    Topics: Animals; Capsaicin; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Mycobacterium; Myelitis; Nociceptors; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord

1998
Involvement of capsaicin sensitive primary afferents in thymulin-induced hyperalgesia.
    Journal of neuroimmunology, 1998, Nov-02, Volume: 91, Issue:1-2

    Topics: Animals; Capsaicin; Hyperalgesia; Injections, Intraperitoneal; Interleukin-1; Nerve Growth Factors; Neurons, Afferent; Pain Threshold; Rats; Rats, Sprague-Dawley; Thymic Factor, Circulating; Vagotomy; Vagus Nerve

1998
Lipopolysaccharide-induced hyperalgesia of intracranial capsaicin sensitive afferents in conscious rats.
    Pain, 1998, Volume: 78, Issue:3

    Topics: Animals; Behavior, Animal; Brain; Capsaicin; Cerebral Ventricles; Escape Reaction; Exploratory Behavior; Grooming; Hyperalgesia; Injections, Intraventricular; Lipopolysaccharides; Male; Neurons, Afferent; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Solitary Nucleus; Trigeminal Caudal Nucleus

1998
A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance.
    Neuroscience, 1998, Volume: 86, Issue:2

    Topics: Animals; Capsaicin; Carrageenan; Functional Laterality; Hindlimb; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; Spinal Cord

1998
The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat.
    British journal of pharmacology, 1999, Volume: 126, Issue:1

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Capsaicin; Carrageenan; Dinoprostone; Dose-Response Relationship, Drug; Excipients; Hindlimb; Hyperalgesia; Inflammation; Inflammation Mediators; Male; Nociceptors; Oxytocics; Pain; Pain Threshold; Rats; Rats, Wistar; Thionucleotides; Ultraviolet Rays

1999
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.
    Pain, 1999, Volume: 79, Issue:2-3

    Topics: Animals; Capsaicin; Diterpenes; Hyperalgesia; Ligation; Male; Neurons, Afferent; Pain; Pain Measurement; Peripheral Nervous System; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Time Factors

1999
Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons.
    Journal of neurophysiology, 1999, Volume: 81, Issue:3

    Topics: Animals; Capsaicin; Enzyme Inhibitors; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis; Male; Microdialysis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Spinal Cord; Spinothalamic Tracts

1999
Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation.
    Neurology, 1999, Mar-23, Volume: 52, Issue:5

    Topics: Adult; Body Temperature; Capsaicin; Female; Humans; Hyperalgesia; Male; Pain; Regional Blood Flow; Skin; Sympathetic Nervous System; Vasodilation

1999
The cannabinoid receptor agonist WIN 55,212-2 mesylate blocks the development of hyperalgesia produced by capsaicin in rats.
    Pain, 1999, Volume: 81, Issue:1-2

    Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Capsaicin; Hot Temperature; Hyperalgesia; Male; Morpholines; Motor Activity; Naphthalenes; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug

1999
Neurokinin-1 receptors are involved in behavioral responses to high-intensity heat stimuli and capsaicin-induced hyperalgesia in mice.
    Anesthesiology, 1999, Volume: 90, Issue:6

    Topics: Animals; Capsaicin; Hot Temperature; Hyperalgesia; Mice; Mice, Inbred BALB C; Mice, Knockout; Pain; Reaction Time; Receptors, Neurokinin-1

1999
Role of intracellular calcium in thermal allodynia and hyperalgesia in diabetic mice.
    Brain research, 1999, Jul-03, Volume: 833, Issue:2

    Topics: Animals; Calcium; Capsaicin; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain Threshold; Reaction Time; Reflex; Ryanodine; Spinal Cord; Thapsigargin

1999
Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice.
    European journal of pharmacology, 1999, May-21, Volume: 372, Issue:3

    Topics: Analysis of Variance; Animals; Capsaicin; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred ICR; Naphthalenes; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Spinal Cord

1999
Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study.
    Neurology, 1999, Aug-11, Volume: 53, Issue:3

    Topics: Adult; Brain; Capsaicin; Female; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Pain; Pain Measurement

1999
Tourniquet constriction exacerbates hyperalgesia-related pain induced by intradermal capsaicin injection.
    Anesthesiology, 1999, Volume: 91, Issue:3

    Topics: Administration, Cutaneous; Adult; Capillaries; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Regional Blood Flow; Skin; Tourniquets

1999
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
    Life sciences, 1999, Volume: 65, Issue:10

    Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Postural Balance

1999
Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?
    Pain, 1999, Volume: 83, Issue:2

    Topics: Animals; Capsaicin; Disease Models, Animal; Functional Laterality; Hot Temperature; Hyperalgesia; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatica

1999
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:3

    Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Carrageenan; Dinoprostone; Dipeptides; Dose-Response Relationship, Drug; Edema; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Pain; Rats; Rats, Wistar; Receptor, Bradykinin B2; Time Factors

1999
Secondary hyperalgesia to punctate mechanical stimuli. Central sensitization to A-fibre nociceptor input.
    Brain : a journal of neurology, 1999, Volume: 122 ( Pt 12)

    Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Nerve Block; Neural Conduction; Nociceptors; Pain Measurement; Radial Nerve; Touch

1999
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1

    Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Pain Measurement; Sesquiterpenes

2000
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
    Psychopharmacology, 2000, Volume: 148, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Local; Animals; Azocines; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Fentanyl; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu

2000
No effect of sympathetic sudomotor activity on capsaicin-evoked ongoing pain and hyperalgesia.
    Pain, 2000, Volume: 84, Issue:2-3

    Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Physical Stimulation; Skin; Skin Temperature; Sweat Glands; Sympathetic Nervous System

2000
Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres.
    Brain : a journal of neurology, 2000, Volume: 123 Pt 3

    Topics: Adult; Capsaicin; Electric Stimulation; Electrophysiology; Female; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Pain; Reaction Time; Skin; Stimulation, Chemical

2000
Endothelin-1-induced ET(A) receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ET(B) receptor activation.
    British journal of pharmacology, 2000, Volume: 129, Issue:5

    Topics: Animals; Atrasentan; Capsaicin; Edema; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hyperalgesia; Male; Mice; Nociceptors; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Viper Venoms

2000
The effect of peripheral opioid block and body cooling on sensitivity to heat in capsaicin-treated skin.
    Anesthesia and analgesia, 2000, Volume: 90, Issue:4

    Topics: Adolescent; Adult; Capsaicin; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Naloxone; Receptors, Opioid

2000
A new animal model for assessing mechanisms and management of muscle hyperalgesia.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Hand Strength; Hyperalgesia; Male; Muscle, Skeletal; Muscular Diseases; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley

2000
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
    Nature, 2000, May-11, Volume: 405, Issue:6783

    Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Carrageenan; Cells, Cultured; Electrophysiology; Endocannabinoids; Female; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Targeting; Hot Temperature; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Pain; Polyunsaturated Alkamides; Receptors, Drug; Stem Cells; TRPV Cation Channels

2000
ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia.
    Brain : a journal of neurology, 2000, Volume: 123 ( Pt 6)

    Topics: Adenosine Triphosphate; Adult; Capsaicin; Drug Synergism; Female; Humans; Hyperalgesia; Iontophoresis; Male; Neurons, Afferent; Nociceptors; Pain; Regional Blood Flow; Skin; Touch; Ultraviolet Rays

2000
Repetitive intradermal capsaicin: differential effect on pain and areas of allodynia and punctate hyperalgesia.
    Somatosensory & motor research, 2000, Volume: 17, Issue:1

    Topics: Adult; Afferent Pathways; Capsaicin; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Nociceptors; Pain Measurement; Pain Threshold; Spinal Cord; Synaptic Transmission

2000
Prostaglandin E(2)-mediated sensitization of rat sensory neurons is not altered by nerve growth factor.
    Neuroscience letters, 2000, Jun-16, Volume: 287, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cyclic AMP; Dinoprostone; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Nerve Growth Factor; Neurons, Afferent; Nociceptors; Rats; Rats, Sprague-Dawley

2000
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
    Neuroscience, 2000, Volume: 98, Issue:2

    Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Physical Stimulation; Plant Extracts; Plant Oils; Receptors, Neurokinin-1; Substance P; Urinary Bladder; Visceral Afferents

2000
Activation of the somatosensory cortex during Abeta-fiber mediated hyperalgesia. A MSI study.
    Brain research, 2000, Jul-14, Volume: 871, Issue:1

    Topics: Adult; Afferent Pathways; Capsaicin; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Forearm; Humans; Hyperalgesia; Magnetics; Male; Nerve Fibers; Neurons; Somatosensory Cortex

2000
Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-01, Volume: 20, Issue:15

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Cell Separation; Drug Resistance; Foot; Hyperalgesia; Injections, Subcutaneous; Male; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Phenotype; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Signal Transduction; Skin

2000
Capsaicin and nociception: from basic mechanisms to novel drugs.
    Lancet (London, England), 2000, Sep-02, Volume: 356, Issue:9232

    Topics: Capsaicin; Hot Temperature; Humans; Hyperalgesia; Models, Biological; Nociceptors; Receptors, Drug; TRPV Cation Channels

2000
Effect of mexiletine on thermal allodynia and hyperalgesia in diabetic mice.
    Japanese journal of pharmacology, 2000, Volume: 84, Issue:1

    Topics: Analgesics; Animals; Capsaicin; Diabetes Complications; Drug Interactions; Hot Temperature; Hyperalgesia; Male; Mexiletine; Mice; Mice, Inbred ICR; Pain Measurement

2000
Antinociceptive activity of ricinoleic acid, a capsaicin-like compound devoid of pungent properties.
    European journal of pharmacology, 2000, Oct-27, Volume: 407, Issue:1-2

    Topics: Administration, Topical; Animals; Capsaicin; Carrageenan; Conjunctiva; Guinea Pigs; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Ricinoleic Acids

2000
In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue.
    Pain, 2000, Dec-15, Volume: 89, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Blinking; Blood Pressure; Bronchoconstriction; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Eye; Female; Ganglia, Spinal; Guinea Pigs; Hindlimb; Hyperalgesia; Irritants; Male; Mice; Mice, Inbred Strains; Nociceptors; Nose; Odorants; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Turpentine; Urea

2000
A novel transverse push-pull microprobe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn.
    Journal of neurochemistry, 2001, Volume: 76, Issue:1

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Animals; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Male; Microdialysis; Nitrophenols; Physical Stimulation; Posterior Horn Cells; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Spinal Cord; Theophylline

2001
The capsaicin analogue SDZ249-665 attenuates the hyper-reflexia and referred hyperalgesia associated with inflammation of the rat urinary bladder.
    Pain, 2001, Volume: 89, Issue:2-3

    Topics: Algorithms; Analgesics; Animals; Capsaicin; Cystitis; Dose-Response Relationship, Drug; Hyperalgesia; Male; Rats; Rats, Wistar; Reflex; Time Factors; Turpentine; Urea; Urination

2001
Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice.
    Pain, 2001, Feb-01, Volume: 90, Issue:1-2

    Topics: Animals; Capsaicin; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Reaction Time; Receptors, Neurokinin-1

2001
The role of spinal cholecystokinin B receptors in thermal allodynia and hyperalgesia in diabetic mice.
    Brain research, 2001, Feb-23, Volume: 892, Issue:2

    Topics: Animals; Capsaicin; Cholecystokinin; Diabetes Mellitus, Experimental; Enzyme Activators; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Male; Meglumine; Mice; Mice, Inbred ICR; Nerve Fibers; Nociceptors; Pain; Protein Kinase C; Reaction Time; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Spinal Cord

2001
Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Freund's Adjuvant; Hyperalgesia; Ketorolac; Macaca mulatta; Male; Morphine; Pain; Pain Measurement; Piperazines; Receptors, Opioid, delta

2001
Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity.
    Journal of neurochemistry, 2001, Volume: 76, Issue:6

    Topics: Afferent Pathways; Animals; Axonal Transport; Capsaicin; Colchicine; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Nerve Endings; Oligodeoxyribonucleotides, Antisense; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Nerve; Transcription, Genetic

2001
Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection.
    Pain, 2001, Volume: 91, Issue:3

    Topics: Administration, Topical; Animals; Bee Venoms; Capsaicin; Hot Temperature; Hyperalgesia; Male; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve

2001
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jun-05, Volume: 98, Issue:12

    Topics: Adenosine Triphosphate; Capsaicin; Cells, Cultured; Drug Synergism; Humans; Hyperalgesia; Pain; Protein Kinase C; Receptors, Drug; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate

2001
A new model of visceral pain and referred hyperalgesia in the mouse.
    Pain, 2001, Volume: 92, Issue:3

    Topics: Abdomen; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Extravasation of Diagnostic and Therapeutic Materials; Female; Hindlimb; Hyperalgesia; Male; Mice; Morphine; Mustard Plant; Pain; Plant Extracts; Plant Oils; Touch

2001
Knee joint mobilization reduces secondary mechanical hyperalgesia induced by capsaicin injection into the ankle joint.
    European journal of pain (London, England), 2001, Volume: 5, Issue:1

    Topics: Animals; Ankle Joint; Arthritis; Capsaicin; Disease Models, Animal; Hyperalgesia; Injections, Intra-Articular; Knee Joint; Male; Movement; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley

2001
Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jul-15, Volume: 21, Issue:14

    Topics: Adenosine Triphosphate; Animals; Bradykinin; Calcium; Capsaicin; Cells, Cultured; Chemokines; Fluorescent Dyes; Ganglia, Spinal; HIV Envelope Protein gp120; Hyperalgesia; Inflammation; Intracellular Fluid; Male; Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, CCR4; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Substance P

2001
Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms.
    Pain, 2001, Volume: 93, Issue:3

    Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Capsaicin; Hyperalgesia; Male; Morpholines; Naphthalenes; Neurons, Afferent; Pain Measurement; Peripheral Nerves; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord

2001
Influence of capsaicin cream in rats with peripheral neuropathy.
    Pharmacological research, 2001, Volume: 44, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Benzamides; Capsaicin; Carrageenan; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Isoindoles; Male; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Piperidines; Postoperative Period; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance Withdrawal Syndrome; Time Factors

2001
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia.
    Brain : a journal of neurology, 2001, Volume: 124, Issue:Pt 9

    Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Myelinated; Nociceptors; Pain; Radial Nerve; Somatosensory Disorders

2001
Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons.
    The European journal of neuroscience, 2001, Volume: 14, Issue:2

    Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Binding Sites; Capsaicin; Drosophila Proteins; Fluorescent Antibody Technique; Ganglia, Spinal; Hyperalgesia; Lectins; Microscopy, Confocal; Pain Measurement; Pain Threshold; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Drug; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Skin; Substance P

2001
Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens.
    Neuroscience, 2001, Volume: 106, Issue:1

    Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Male; Mecamylamine; Morphine; Narcotics; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tobacco Use Disorder

2001
Pain increases during sympathetic arousal in patients with complex regional pain syndrome.
    Neurology, 2001, Oct-09, Volume: 57, Issue:7

    Topics: Adolescent; Adult; Arousal; Capsaicin; Cold Temperature; Complex Regional Pain Syndromes; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Norepinephrine; Reflex, Startle; Sympathetic Nervous System

2001
Non-noxious A fiber afferent input enhances capsaicin-induced mechanical hyperalgesia in the rat.
    Pain, 2001, Volume: 94, Issue:2

    Topics: Animals; Behavior, Animal; Capsaicin; Electric Stimulation; Hyperalgesia; Male; Nerve Fibers, Myelinated; Neuralgia; Physical Stimulation; Rats; Rats, Sprague-Dawley

2001
Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons.
    Neuroreport, 2001, Dec-04, Volume: 12, Issue:17

    Topics: Animals; Capsaicin; Cell Count; Cell Size; Fluorescent Antibody Technique; Fluorescent Dyes; Ganglia, Spinal; Hyperalgesia; Nerve Fibers; Nerve Fibers, Myelinated; Neurofilament Proteins; Neurons, Afferent; Nociceptors; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Drug; Synaptic Transmission; TRPV Cation Channels

2001
Vasodilatation in hyperalgesic rat skin evoked by stimulation of afferent A beta-fibers: further evidence for a role of dorsal root reflexes in allodynia.
    Pain, 2001, Volume: 94, Issue:3

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Electric Stimulation; Female; Hyperalgesia; Miotics; Mustard Plant; Nerve Fibers, Myelinated; Peptide Fragments; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Reflex; Regional Blood Flow; Rhizotomy; Skin; Spinal Nerve Roots; Sural Nerve; Vasodilation

2001
Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats.
    Neuroscience letters, 2002, Jan-18, Volume: 318, Issue:1

    Topics: Animals; Animals, Newborn; Capsaicin; Coloring Agents; Complex Regional Pain Syndromes; Denervation; Disease Models, Animal; Edema; Electric Stimulation; Hindlimb; Hyperalgesia; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sciatic Nerve

2002
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-19, Volume: 99, Issue:4

    Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Temperature; Hyperalgesia; Inflammation; Knee; Male; Mice; Mice, Inbred ICR; Mustard Plant; Neurons; Pain; Pain Threshold; Peptoids; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Receptors, Drug; Recombinant Proteins; Stress, Mechanical; Time Factors; Xenopus

2002
Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents.
    Brain research, 2002, Mar-15, Volume: 930, Issue:1-2

    Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Behavior, Animal; Capsaicin; Gangliosides; Hyperalgesia; Infusions, Intravenous; Injections, Spinal; Male; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley

2002
Capsaicin-sensitive primary afferents mediate responses to cold in rats with a peripheral mononeuropathy.
    Neuroreport, 2002, Mar-25, Volume: 13, Issue:4

    Topics: Animals; Cannabinoids; Capsaicin; Cold Temperature; Diterpenes; Hindlimb; Hyperalgesia; Ligation; Male; Mononeuropathies; Neurons, Afferent; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Nerve

2002
Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain.
    Pain, 2002, Volume: 96, Issue:1-2

    Topics: Adult; Aged; Capsaicin; Central Nervous System Diseases; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Neurons, Afferent; Pain Threshold; Peripheral Nervous System Diseases; Touch

2002
Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:5

    Topics: Animals; Bupivacaine; Capsaicin; Carrageenan; Diterpenes; Hyperalgesia; Male; Nerve Block; Peripheral Nerves; Rats; Rats, Sprague-Dawley

2002
Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-15, Volume: 22, Issue:10

    Topics: Animals; Behavior, Animal; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Enzyme Inhibitors; Exploratory Behavior; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; Microdialysis; Pain Measurement; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spinal Cord; Sulfonamides

2002
Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity.
    Pain, 2002, Volume: 97, Issue:1-2

    Topics: Animals; Bee Venoms; Capsaicin; Carrageenan; Dynorphins; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Multivariate Analysis; Neurogenic Inflammation; Nociceptors; Pain; Pain Measurement; Species Specificity; Tail

2002
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Jun-11, Volume: 99, Issue:12

    Topics: Animals; Capsaicin; Cell Line; Humans; Hyperalgesia; Rats; Receptors, Drug; Recombinant Proteins; Transfection

2002
Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:5

    Topics: Animals; Animals, Newborn; Capsaicin; Dynorphins; Enkephalins; Female; Foot Diseases; Gene Expression; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Substance P

1992
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
    British journal of pharmacology, 1992, Volume: 107, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Female; Freund's Adjuvant; Hyperalgesia; Irritants; Mice; Morphine; Naloxone; Pain Measurement; Rats; Rats, Wistar; Uric Acid

1992
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
    The Journal of physiology, 1992, Volume: 448

    Topics: Capsaicin; Cold Temperature; Evoked Potentials; Female; Humans; Hyperalgesia; Male; Nociceptors; Pain Measurement; Physical Stimulation; Sensory Thresholds; Time Factors

1992
Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans.
    The Journal of physiology, 1992, Volume: 448

    Topics: Adult; Capsaicin; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Mechanoreceptors; Middle Aged; Nerve Block; Nerve Fibers, Myelinated; Neural Conduction; Pain Measurement; Sensory Thresholds; Time Factors

1992
Noxious heat hyperalgesia test instrument.
    Clinical and experimental neurology, 1991, Volume: 28

    Topics: Capsaicin; Diabetic Neuropathies; Hot Temperature; Humans; Hyperalgesia; Least-Squares Analysis; Sensory Thresholds; Skin

1991
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms.
    Journal of neurophysiology, 1991, Volume: 66, Issue:1

    Topics: Adult; Aged; Anesthesia, Local; Capsaicin; Central Nervous System; Female; Humans; Hyperalgesia; Lymph; Male; Middle Aged; Nerve Fibers; Nervous System Physiological Phenomena; Neurons; Pain; Peripheral Nerves; Physical Stimulation; Psychophysics; Regional Blood Flow; Skin

1991
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia.
    Journal of neurophysiology, 1991, Volume: 66, Issue:1

    Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Intradermal; Macaca fascicularis; Nerve Fibers; Nervous System Physiological Phenomena; Nociceptors; Pain; Physical Stimulation; Skin

1991
Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.
    Journal of neurophysiology, 1991, Volume: 66, Issue:1

    Topics: Animals; Brain; Capsaicin; Electrophysiology; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Macaca fascicularis; Nervous System Physiological Phenomena; Neurons; Spinothalamic Tracts

1991
Involvement of capsaicin-sensitive neurones in hyperalgesia and enhanced opioid antinociception in inflammation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:6

    Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Freund's Adjuvant; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Morphine; Narcotics; Neurons; Nociceptors; Pressure; Rats; Rats, Inbred Strains; Time Factors; Vasodilation

1990
A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats.
    Neuroscience letters, 1990, Jul-17, Volume: 115, Issue:1

    Topics: Afferent Pathways; Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Hot Temperature; Hyperalgesia; Hyperesthesia; Lasers; Male; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Reference Values; Sensory Thresholds; Skin; Touch

1990
Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin.
    Pain, 1989, Volume: 38, Issue:1

    Topics: Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Hyperesthesia; Pain; Pain Measurement; Physical Stimulation; Time Factors

1989
Heat and mechanical hyperalgesia induced by capsaicin. Cross modality threshold modulation in human C nociceptors.
    Brain : a journal of neurology, 1989, Volume: 112 ( Pt 5)

    Topics: Biomechanical Phenomena; Body Temperature; Capsaicin; Constriction; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Hyperesthesia; Nerve Block; Nociceptors; Pain; Physical Stimulation; Sensory Thresholds; Skin

1989
Hyperalgesia mediated by peripheral opiate receptors in the rat.
    Behavioural brain research, 1985, Volume: 17, Issue:3

    Topics: Administration, Topical; Animals; Behavior, Animal; Capsaicin; Etorphine; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Opioid

1985
Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury.
    Brain research, 1987, Feb-24, Volume: 404, Issue:1-2

    Topics: Animals; Burns; Capsaicin; Central Nervous System; Guanethidine; Hyperalgesia; Hyperesthesia; Male; Nerve Block; Nerve Fibers; Pain; Peripheral Nerves; Procaine; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Skin

1987