capsaicin has been researched along with Allodynia in 714 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (0.56) | 18.7374 |
| 1990's | 95 (13.31) | 18.2507 |
| 2000's | 304 (42.58) | 29.6817 |
| 2010's | 259 (36.27) | 24.3611 |
| 2020's | 52 (7.28) | 2.80 |
| Authors | Studies |
|---|---|
| Ann, J; Blumberg, PM; Choi, K; Esch, TE; Ha, HJ; Hwang, SW; Kim, H; Kim, HS; Kim, M; Kim, YH; Lee, J; Pearce, LV; Thorat, SA; Turcios, NA | 1 |
| Gao, J; Guo, Y; Hu, X; Huang, H; Jin, Z; Li, Z; Liu, Z; Wang, K; Wang, Y; Zhang, L; Zhong, Y; Zong, X | 1 |
| Blockeel, AJ; Caspani, O; Cosentino, C; Di Lionardo, A; Di Pietro, G; Di Stefano, G; Garcia-Larrea, L; Leone, C; Malara, E; Mollica, C; Mouraux, A; Phillips, KG; Sgro, E; Treede, RD; Truini, A; Valeriani, M | 1 |
| Bang, SK; Cho, SJ; Choi, KH; Kang, SY; Ryu, Y; Seo, SY | 1 |
| Blockeel, AJ; Caspani, O; Di Lionardo, A; Di Pietro, G; Di Stefano, G; Falco, P; Garcia-Larrea, L; Leone, C; Mouraux, A; Phillips, KG; Treede, RD; Truini, A | 1 |
| Arora, V; Asgar, J; Chung, MK; Kumari, S; Li, T; Wang, S | 1 |
| Gao, L; Gao, Y; Li, D; Liu, Q; Mo, X; Pang, P; Tian, Q; Wang, Y; Wei, X; Xie, C; Xiong, T; Yao, J; Zhang, Y; Zhong, B | 1 |
| Andersen, OK; Arendt-Nielsen, L; Hugosdottir, R; Kasting, M; Mørch, CD | 1 |
| Fischer, MJM; Reeh, PW | 1 |
| Borghi, SM; Brasil-Silva, L; Casagrande, R; Chichorro, JG; Cunha, JM; Fattori, V; Ferraz, CR; Verri, WA; Zaninelli, TH | 1 |
| Berg, KA; Chavera, TS; Clarke, WP; Jamshidi, RJ; Jennings, EM; LoCoco, PM; Smith, HR; Sullivan, LC | 1 |
| Mickle, AD; Mohapatra, DP; Robilotto, GL; Shepherd, AJ | 1 |
| Basedau, H; Jürgens, T; May, A; Ortlieb, L; Peng, KP | 1 |
| Chen, H; Hachisuka, J; Ibinson, J; Koerber, HR; Ross, SE; Salsovic, J; Sheahan, TD; Smith, KM; Warwick, C | 1 |
| Cobos, EJ; Egea, J; Entrena, JM; García, AG; López, MG; Maroto, M; Montell, E; Padín, JF; Vergés, J | 1 |
| Fuseya, S; Ishida, K; Ishida, T; Ito, M; Kawamata, M; Sakamoto, A; Tanaka, S | 1 |
| Garcia-Larrea, L; Hagiwara, K; Perchet, C; Salameh, C | 1 |
| Jo, HJ; Kim, YH; Park, CK; Rahman, MM | 1 |
| Kringel, D; Lötsch, J; Mayer, B | 1 |
| Ishida, S; Kikuchi, K; Murata, M; Tagawa, Y | 1 |
| Arendt-Nielsen, L; Curatolo, M; Graven-Nielsen, T; Schliessbach, J; Siegenthaler, A | 1 |
| Guo, J; Song, Y; Tang, J; Tang, Z; Yang, Y; Yu, G; Zhu, C | 1 |
| Bourojeni, FB; Davidova, A; Kania, A; Mogil, JS; Petitjean, H; Sharif-Naeini, R; Sotocinal, SG; Tsao, D | 1 |
| da Silva, JT; Ro, JY; Tricou, C; Yang, D; Zhang, R; Zhang, Y | 1 |
| Aguiar, DA; Chichorro, JG; Dos Reis, RC; Kopruszinski, CM; Nones, CFM | 1 |
| Ferreiros, N; Geisslinger, G; Lötsch, J; Oertel, BG; Rossmanith, T; Walter, C; Wolters, M; Zinn, S; Zunftmeister, M | 1 |
| Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS | 1 |
| Andersen, EOL; Fischer, L; Gaspar, JC; Guilhen, VA; Lazzarim, MK; Polato, JJ; Sardi, NF; Tobaldini, G | 1 |
| Artico, M; Giacomoni, C; Lattanzi, R; Maftei, D; Severini, C; Vellani, V | 1 |
| Burton, EF; Campbell, CM; Fulton, BA; Letzen, JE; Nance, S | 1 |
| Kawabata, A; Matsui, K; Sekiguchi, F; Terada, Y; Tsubota, M | 1 |
| Hughes, SW; Strutton, PH; Ward, G | 1 |
| Banik, RK; Johns, ME; Kabadi, RA; McAdams, B; Simone, DA; Uhelski, ML | 1 |
| Acampora, G; Arout, CA; DeNegre, D; Koretski, J; Newcomb, J; Perrino, AC; Petrakis, IL; Ralevski, E | 1 |
| Basra, M; Chan, C; Gomes, S; Hughes, SW; Parr, C; Strutton, PH; Wong, F | 1 |
| Antunes, FTT; Caminski, ES; Dallegrave, E; de Freitas, LM; de Souza, AH; Gomez, MV; Junior, CADS; Pereira, EMR | 1 |
| Aldossary, SA; Alsalem, M; Altarifi, A; Azab, B; El-Salem, K; Haddad, M; Jaffal, SM; Kalbouneh, H; Mustafa, AG | 1 |
| Baumgärtner, U; C Rosenberger, D; Greffrath, W; Henrich, F; Magerl, W; Shabes, P; Treede, RD | 1 |
| Cabeça, LF; Costa, JSR; Couto, VM; Franco, MKKD; Franz-Montan, M; Geraldes, DC; Oliveira-Nascimento, L; Paula, E; Riske, KA; Yokaychiya, F | 1 |
| Curt, A; Hubli, M; Rosner, J; Scheuren, PS | 1 |
| González-Anduaga, GM; López-Ortíz, M; Navarrete, A; Palomino-Hernández, O; Quiñonez-Bastidas, GN; Regla, I; Rocha-González, HI | 1 |
| Bach, H; Carranza, A; Gorzalczany, SB; Rodríguez Basso, A; Zainutti, VM | 1 |
| Anderson, T; Dodick, DW; Kopruszinski, CM; Navratilova, E; Porreca, F; Schwedt, TJ; Swiokla, J; Turnes, JM; Weinstein, TJ | 1 |
| Lin, CL; Lu, CC; Lu, YY; Tsai, HP; Wu, CH; Wu, MK | 1 |
| Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A | 1 |
| Ferreira, J; Ferreira, MA; Lückemeyer, DD; Macedo-Júnior, SJ; Prudente, AS; Schran, RG; Silva, AM; Tonello, R | 1 |
| Brix Finnerup, N; Caspani, O; Garcia-Larrea, L; Ho, I; Kostenko, A; Leone, C; Mouraux, A; Nochi, Z; Pickering, G; Quesada, C; Stouffs, A; Tracey, I; Treede, RD; Truini, A; Wittayer, M | 1 |
| Hara, K; Haranishi, Y; Terada, T | 1 |
| Allison, C; John Z, S; Korey, L | 1 |
| Dorsey, SG; Greenspan, JD; Keaser, ML; Liu, Y; Meeker, TJ; Schmid, AC; Seminowicz, DA | 1 |
| Chung, JM; Hankerd, K; La, JH; McDonough, KE; Tang, SJ; Wang, J | 1 |
| Wallace, MS | 1 |
| Casals-Diaz, L; Dolly, O; Edupuganti, OP; Meng, J; Moriarty, O; Nealon, J; Wang, J; Zurawski, T | 1 |
| Birklein, F; Breimhorst, M; Diener, SA; Drummond, PD; Geber, C; Krämer, HH; Vogt, T | 1 |
| Borbély, É; Dénes, Á; Gaszner, B; Helyes, Z; Hunyady, Á; Környei, Z; Scheich, B; Szőke, É; Szolcsányi, J; Vincze, P | 1 |
| Araya, EI; Chichorro, JG; Cunha, JMD; Ferreira, LEN; Kopruszinski, CM; Nones, CFM | 1 |
| Artacho-Cordón, A; Cendán, CM; Entrena, JM; González-Cano, R; Nieto, FR; Tejada, MÁ; Wood, JN | 1 |
| Albuquerque, TR; Alcantara, IS; Araújo, AAS; Araújo-Filho, HG; Barreto, RSS; Coutinho, HDM; Martins, AOBPB; Menezes, IRA; Menezes, PP; Pereira, EWM; Quintans, JSS; Quintans-Júnior, LJ; Rezende, MM; Silva, BAF | 1 |
| Geisslinger, G; Heinemann, S; Lerch, F; Lötsch, J; Oertel, BG; Ultsch, A | 1 |
| Giesler, GJ; Khasabov, SG; Malecha, P; Noack, J; Simone, DA; Tabakov, J | 1 |
| Attal, N; Ernault, E; Gálvez, R; Maihöfner, C; Moyle, G; Navez, ML; Nurmikko, TJ; Stoker, M | 1 |
| Duff, EP; Löken, LS; Tracey, I | 1 |
| Fahey, E; Gandhi, W; Nadeau, C; Price, RC; Qu, A; Schweinhardt, P; Stone, L; Tarnavskiy, R | 1 |
| Albu, S; Haney, R; Meagher, MW; You, DS | 1 |
| Gurtskaia, G; Nozadze, I; Tsagareli, MG; Tsiklauri, N | 1 |
| Furman, AJ; Goodman, RN; Keaser, ML; Mazaheri, A; Meeker, TJ; Muthulingam, J; Prokhorenko, M; Rietschel, JC; Seminowicz, DA; Yoo, S | 1 |
| Beitz, AJ; Kim, SJ; Kwon, SG; Lee, JH; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Cruccu, G; Ernault, E; Haanpää, M; McBride, WT; Nurmikko, TJ; Riaz, FK | 1 |
| Aloisi, AM; Bachiocco, V; Bennett, DLH; Bogdanov, YD; Bras, JT; Cox, JJ; Emery, EC; Follenfant, M; Gossage, SJ; Gras, M; Habib, AM; Houlden, H; Humphrey, J; Kolesnikov, A; Komine, Y; Le Cann, K; Li, S; Maniatis, N; Marsili, L; Matsuyama, A; Minett, MS; Okorokov, AL; Panov, KI; Pereira, V; Ponsolles, C; Ramirez, JD; Santana-Varela, S; Sikandar, S; Torres, JM; Wood, JN; Yamamori, T; Yamaoka, K; Zhao, J | 1 |
| Chang, KC; Chao, CC; Chiang, H; Hsieh, ST; Hsueh, HW; Kan, HW; Lin, YH; Tseng, MT; Wu, SW | 1 |
| Béjar, J; Chávez, D; Contreras-Hernández, E; Cortés, U; Glusman, S; Hernández, E; Martín, M; Reyes, P; Rudomin, P; Velázquez, E | 1 |
| Baron, R; Binder, A; Enax-Krumova, EK; Geisslinger, G; Gierthmühlen, J; Henrich, F; Hüllemann, P; Klein, T; Lötsch, J; Magerl, W; Maier, C; Oertel, B; Schuh-Hofer, S; Tölle, TR; Treede, RD; Vollert, J | 1 |
| Drewes, AM; Larsen, IM; Olesen, AE | 1 |
| Christoph, T; Kögel, B; Peters, T; Schiene, K; Schröder, W | 1 |
| Blum, R; Brack, A; Kloka, J; Martin, C; Mohammadi, M; Oehler, B; Rittner, HL | 1 |
| Klumpp, DJ; Miller, RJ; Rosen, JM; Schaeffer, AJ; Woida, PJ; Yaggie, RE | 1 |
| Davidova, A; Lesperance, LS; Macpherson, A; Mouchbahani-Constance, S; Petitjean, H; Prescott, SA; Sharif-Naeini, R | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Gu, Y; Huang, LM; Li, G | 1 |
| Aboud, M; Comai, S; De Gregorio, D; Enns, J; Gobbi, G; Lopez-Canul, M; Maione, S; McLaughlin, RJ; Ochoa-Sanchez, R; Posa, L | 1 |
| Fischer, L; Lamana, MS; Miranda, J; Tambeli, CH; Tobaldini, G | 1 |
| Barik, A; Bharucha-Goebel, D; Bönnemann, CG; Bushnell, MC; Case, L; Chesler, AT; Donkervoort, S; Foley, AR; Ghitani, N; Gordon, T; Lam, R; Liljencrantz, J; Necaise, A; Saade, D; Szczot, M; Thompson, JH | 1 |
| Daou, I; Dubin, AE; Francisco, AG; Keenan, WT; Kühnemund, J; Lewin, GR; Loud, MC; Marshall, KL; Murthy, SE; Patapoutian, A; Schwaller, F | 1 |
| Abdelaziz, R; Barry, AM; Gomez-Varela, D; Jahn, O; Kügler, S; Michel, N; Schmidt, M; Sondermann, JR | 1 |
| Bjurstrom, MF; Finan, PH; Gonzalez, K; Irwin, MR; Remeniuk, B; Robinson, M; Smith, MT; Speed, TJ; Tompkins, DA | 1 |
| Borbély, É; Botz, B; Helyes, Z; Kiss, T; Pintér, E; Szabadfi, K; Szolcsányi, J | 1 |
| Baudouin, C; Ben-Dhaou, C; Melik Parsadaniantz, S; Ouimet, T; Poras, H; Reaux-Le Goazigo, A; Wurm, M | 1 |
| Adamek, P; Heles, M; Palecek, J | 1 |
| Curry, RS; Eisenach, JC; Harris, L; Street, LM | 1 |
| Barragán-Iglesias, P; Flores-Murrieta, FJ; Granados-Soto, V; Huerta-Cruz, JC; Pineda-Farias, JB; Quiñonez-Bastidas, GN; Reyes-García, JG; Roa-Coria, JE; Rocha-González, HI; Zúñiga-Romero, Á | 1 |
| Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E | 1 |
| Lötsch, J; Weyer-Menkhoff, I | 1 |
| Bereiter, DA; Iinuma, T; Iwata, K; Katagiri, A; Lee, J; Ohara, K; Okada, S; Saito, H | 1 |
| Chong, J; Eilers, H; Guan, Z; Kawamata, T; Lee, J; Maruyama, T; Philipsen, S; Schumacher, M; Sharma, M; Sheehan, K; Xu, Z; Zavala, K | 1 |
| Baycu, C; Bektur, E; Can, OD; Canbek, M; Ceyhan, E; Donmez, DB; Şahin, E | 1 |
| Agelopoulos, K; Conrad, H; Hatt, H; Hidding, J; Lotts, T; Osada, N; Pereira, MP; Pogatzki-Zahn, E; Schmelz, M; Ständer, S | 1 |
| Andersen, OK; Frahm, KS; Mørch, CD | 1 |
| Boligon, AA; da Silva Brum, E; Dalenogare, DP; Damiani, AP; de Almeida, AS; de Andrade, VM; de David Antoniazzi, CT; de Oliveira Sardinha, TT; De Prá, SDT; Ferro, PR; Galvani, NC; Oliveira, SM; Rigo, FK; Strapazzon, G; Trevisan, G | 1 |
| Duan, W; Fang, Y; Ma, C; Xie, Y; Zhu, J | 1 |
| Linde, LD; Srbely, JZ | 1 |
| Barr, GA; Kuburas, A; Luu, AKS; Marquez de Prado, B; Raj, NR; Recober, A; Rossi, HL | 1 |
| Chen, W; Fu, W; Marvizon, JC; Taylor, BK | 1 |
| Buijs, M; Gentgall, M; Hutchinson, MR; Kwok, YH; Rolan, P; Tuke, J; Williams, D | 1 |
| Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A | 1 |
| Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM | 1 |
| Boucher, Y; Carstens, E; Carstens, MI; Merrill, AW; Sawyer, CM; Zanotto, KL | 1 |
| Chen, HS; Li, FP; Li, XQ; Lin, Q; Liu, BJ; Qu, F; Wang, Y; Wen, WW | 1 |
| Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE | 1 |
| Bhattacharyya, MH; Bollag, WB; Clark, SP; Falls, G; Isales, CM; Johnson, M; Ma, F; Westlund, KN; Xie, D | 1 |
| Dahl, JB; Petersen, KL; Rowbotham, MC; Werner, MU | 1 |
| Btesh, J; Fischer, MJM; McNaughton, PA; Stott, K | 1 |
| Bae, YC; Cho, YS; Chung, MK; Lee, J; Ro, JY; Zhang, X | 1 |
| Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA | 1 |
| Gu, JG; Ling, JX; Xu, GY; Zuo, X | 1 |
| Akazawa, C; Ebine, T; Funakubo, M; Iwashita, T; Kayama, Y; Kuroi, T; Nakagawa, T; Okano, H; Sato, H; Shibata, M; Shibata, S; Shimizu, T; Suzuki, N; Toriumi, H; Wajima, K | 1 |
| Khasabov, SG; Simone, DA | 1 |
| Dolan, S; Goldie, M | 1 |
| Córdova, MM; Montrucchio, DP; Santos, AR | 1 |
| Alpizar, YA; Boonen, B; Gees, M; Nilius, B; Sanchez, A; Talavera, K; Voets, T | 1 |
| Büchel, C; Geuter, S | 1 |
| Baggio, CH; Cipriani, TR; da Silva, CF; de Souza, LM; Hamm, LA; Nascimento, AM; Nomura, EC; Rodrigues, MR; Werner, MF | 1 |
| Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JL; Kohli, SK | 1 |
| Wallace, MS; Wong, W | 1 |
| Aschenbrenner, CA; Eisenach, JC; Houle, TT; Peters, CM; Ririe, D | 1 |
| Andreev, YA; Bondarenko, DA; Dyachenko, IA; Grishin, EV; Kabanova, NV; Kolesnikov, SS; Korolkova, YV; Kotova, PD; Kozlov, SA; Murashev, AN; Rogachevskaja, OA; Skobtsov, DI | 1 |
| Alleyne, RT; LeBlanc, BW; Lii, TR; Saab, CY; Silverman, AE | 1 |
| Adamek, P; Kalynovska, N; Mrozkova, P; Palecek, J; Spicarova, D | 1 |
| Akiyama, T; Carstens, E; Carstens, MI; Nagamine, M | 1 |
| Chichorro, JG; Cruz, LS; Kopruszinski, CM | 1 |
| Finnerup, NB; Gierthmühlen, J; Højlund, AP; Jensen, TS; Terkelsen, AJ | 1 |
| Birklein, F; Schlereth, T | 1 |
| Beasley, S; Mark, I; Smith, S; Smith, T; Sweitzer, SM | 1 |
| Andresen, T; Arendt-Nielsen, L; Drewes, AM; Lassen, D; Nielsen, AK; Nilsson, M | 1 |
| Baker, DG; Moeller-Bertram, T; Patel, P; Schilling, JM; Simmons, AN; Strigo, IA | 1 |
| Di Giminiani, P; Herskin, MS; Petersen, LJ | 1 |
| Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
| Chen, CC; Chen, WN | 1 |
| Creech, SK; Meagher, MW; Smith, JS; Vichaya, EG; You, DS; Young, EE | 1 |
| Amaral, LS; Barreiro, EJ; Fraga, CA; Guimaraes, MZ; Lacerda, RB; Lima, CK; Miranda, AL; Quintas, LE; Santos, BL; Silva, RM; Silva, RV | 1 |
| Bonin, RP; De Koninck, Y | 1 |
| Cui, YY; Li, YQ; Qi, J; Shi, J; Wu, HH; Xu, H | 1 |
| Doyle, AP; Gomez, R; Henry, MA; Jeske, NA; Rowan, MP; Szteyn, K | 1 |
| Barrot, M; Barthas, F; Bohren, Y; Hugel, S; Petitjean, H; Schlichter, R; Yalcin, I | 1 |
| Nurmikko, T; Poole, H; Prior, M; Sacco, P | 1 |
| Iida, S; Maruhama, K; Mizutani, M; Sugimoto, T; Terayama, R; Tsuchiya, H | 1 |
| Fan, H; Haines, D; Higgins, T; Howard, OM; Li, J; Lin, H; Oppenheim, JJ; Qi, J; Trivett, A; Wei, H; Zhao, Z | 1 |
| Chichorro, JG; Hummig, W; Kopruszinski, CM | 1 |
| Furukawa, A; Honda, K; Iwata, K; Kita, K; Noma, N; Shinoda, M | 1 |
| Baron, R; Gierthmühlen, J; Jansen, O; Rempe, T; Riedel, C; Stroman, PW; Wolff, S | 1 |
| Iida, S; Maruhama, K; Mizutani, M; Omura, S; Sugimoto, T; Terayama, R; Tsuchiya, H | 1 |
| Barragán-Iglesias, P; Granados-Soto, V; Martínez-Rojas, VA; Murbartián, J; Rocha-González, HI | 1 |
| Harano, N; Hitomi, S; Inenaga, K; Kuramitsu, S; Matoba, M; Matsuo, K; Miyano, K; Ono, K; Ota, Y; Seta, Y; Uezono, Y; Yamaguchi, K | 1 |
| Babić, A; Bach-Rojecky, L; Drinovac, V; Lacković, Z | 1 |
| Athie, M; Dias, EV; Lamana, SM; Miranda, J; Parada, CA; Tambeli, CH | 1 |
| Bölcskei, K; Borbély, É; Botz, B; Csepregi, JZ; Helyes, Z; Kenyér, T; Kereskai, L; Kiss, T; Mócsai, A; Pintér, E; Szolcsányi, J | 1 |
| Moeller-Bertram, T; Silberberg, A; Wallace, MS | 1 |
| Kumamoto, N; Shibata, Y; Ueda, T; Ugawa, S; Watanabe, M | 1 |
| Ando, T; Baad-Hansen, L; Naganawa, T; Svensson, P | 1 |
| Donahue, RR; Grace, PM; Griggs, RB; Morgenweck, J; Sutton, A; Taylor, BK; Watkins, LR | 1 |
| Akopian, AN; Bierbower, SM; Dong, X; Geng, Y; Guan, Y; Jeske, NA; Mo, GC; Patel, KN; Tang, Z; Tiwari, V; Wang, Y; Weng, HJ; Zhang, J; Zheng, Q; Zou, W | 1 |
| Andersen, HH; Arendt-Nielsen, L; Gazerani, P; Nikbakht, A; Poulsen, JN; Uchida, Y | 1 |
| Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K | 1 |
| Filipek, B; Sałat, K | 1 |
| Finnerup, NB; Horjales-Araujo, E; Schaldemose, EL; Svensson, P | 1 |
| Dang, D; Ono, K; Schmidt, BL; Viet, CT; Ye, Y | 1 |
| Allen, KD; Caudle, RM; Jacobs, BY; Kloefkorn, HE; Lakes, EH; Neubert, JK; Rohrs, EL | 1 |
| Baron, R; Enax-Krumova, EK; Maier, C; Mainka, T; Malewicz, NM; Treede, RD | 1 |
| Curt, A; Jutzeler, CR; Kramer, JL | 1 |
| Bogdanov, Y; Crow, M; Denk, F; Grant, AD; Kelleher, JH; Khovanov, N; McMahon, SB; Sharma, S; Wood, JN | 1 |
| Greffrath, W; Henrich, F; Klein, T; Magerl, W; Treede, RD | 1 |
| Loo, L; Mickle, AD; Mohapatra, DP; Shepherd, AJ | 1 |
| Trbovich, M; Yang, H | 1 |
| Chen, PB; Eskander, MA; Flores, ER; Gao, X; Green, DP; Hargreaves, KM; Jeske, NA; Por, ED; Ruparel, S | 1 |
| Bressan, E; Chichorro, JG; Kopruszinski, CM; Reeh, PW; Reis, RC | 1 |
| Geis, C; Lemmer, S; Schießer, P; Sommer, C; Üçeyler, N; Vanegas, H | 1 |
| Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM | 1 |
| Gan, YH; Hao, T; Kou, XX; Ma, XC; Wu, YW | 1 |
| Aoki, S; Dai, Y; Iwaoka, E; Kogure, Y; Matsuyoshi, N; Noguchi, K; Wang, S; Yamamoto, S | 1 |
| Groneberg, AH; Klein, T; Mouraux, A; Pfau, DB; Treede, RD; van den Broeke, EN | 1 |
| Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y | 1 |
| Baron, R; Binder, A; Hüllemann, P; Nerdal, A; Shao, YQ; Watfeh, R | 1 |
| Andersson, J; Kong, Y; Mezue, M; Tracey, I; Wanigasekera, V | 1 |
| Artola, A; Bourgois, N; Dallel, R; Peirs, C | 1 |
| Davletov, B; Ferrari, E; Geranton, SM; Hunt, SP; Leese, C; Maiarú, M; Mangione, AS; Obara, I; Tassorelli, C | 1 |
| Andoh, T; Kuraishi, Y; Sakamoto, A | 1 |
| Li, X; Ma, Y; Sun, L; Wang, T; Wang, X; Zhang, Y | 1 |
| Hall, BE; Jendryke, T; Kulkarni, AB; Milenkovic, VM; Nordmann, GC; Prochazkova, M; Schladt, M; Wetzel, CH | 1 |
| Hoffmann, T; Lattanzi, R; Maftei, D; Negri, L; Reeh, PW | 1 |
| Creech, SK; Meagher, MW; You, DS | 1 |
| Abaei, M; Auer, DP; Chapman, V; Prior, M; Sagar, DR; Spicer, CH; Stockley, EG | 1 |
| Chen, HS; Li, W; Li, XQ; Liu, BJ; Lu, Y; Wang, JX; Zhou, ZH | 1 |
| Dickenson, AH; Iannetti, GD; Lee, MC; Liang, M; O'Neill, J | 1 |
| Egbuniwe, O; Renton, T; Yilmaz, Z | 1 |
| Buitenweg, JR; Doll, RJ; Groeneveld, GJ; Hay, JL; van Amerongen, G; Veltink, PH | 1 |
| Bradshaw, H; Carey, LM; Cornett, B; Hohmann, AG; Leishman, E; Mackie, K; Slivicki, RA | 1 |
| Itomi, Y; Kawamura, T; Tsukimi, Y | 1 |
| Acampora, G; Arout, CA; Koretski, J; Limoncelli, D; Newcomb, J; Perrino, AC; Petrakis, IL; Ralevski, E | 1 |
| Borbély, É; Helyes, Z; Kemény, Á; Markovics, A; McDougall, JJ; Pintér, E; Quinn, JP; Sándor, K; Szolcsányi, J | 1 |
| Baron, R; Binder, A; Dierschke, R; Förster, M; Großkopf, M; Helfert, S; Hüllemann, P; Keller, T | 1 |
| Asad, AB; Baumgartner, R; Chin, CL; Derbyshire, SW; Evelhoch, JL; Feng, D; Henry, B; Houghton, A; Jensen, A; Manigbas, E; Seah, S | 1 |
| Bencsik, P; Boros, K; Dux, M; Fekécs, Z; Ferdinandy, P; Jancsó, G; Katona, M; Nógrádi, A; Oszlács, O; Sántha, P | 1 |
| Bennett, GJ; Bley, K; Coderre, TJ; Gandhi, W; Laferrière, A; Ragavendran, JV; Schweinhardt, P; Ware, MA | 1 |
| Alsalem, M; Altarifi, A; Chapman, V; El-Salem, K; Kendall, DA; Millns, P | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Lacković, Z | 1 |
| Garraway, SM; Grau, JW; Huang, YJ; Lee, KH; Murphy, L | 1 |
| Kim, YN; Ma, W; Rudakou, U; St-Jacques, B | 1 |
| Agbaje, J; Baad-Hansen, L; Constantinus, P; De Laat, A; Svensson, P | 1 |
| Grau, JW; Huang, YJ; Lee, KH | 1 |
| Treede, RD | 1 |
| Baeyens, JM; Cobos, EJ; Entrena, JM; González-Cano, R; Nieto, FR; Sánchez-Fernández, C; Yeste, S | 1 |
| Berta, T; Bey, AL; Chang, W; Han, Q; Ji, RR; Jiang, YH; Kim, YH; Lay, M; Liu, D; Wang, X; Zhang, Y; Zhang, ZJ | 1 |
| Borta, A; Brand, T; Nicolas, LB; Reitmeir, P; Roebling, R; Schaffler, K; Scholpp, J | 1 |
| Andersen, HH; Arendt-Nielsen, L; Elberling, J; Gazerani, P; Hauberg, LE; Sharma, N | 1 |
| Bonacorso, HG; Brum, ES; Brusco, I; Frizzo, CP; Oliveira, SM; Rodrigues, MB; Rosa, WC; Zanatta, N | 1 |
| Bagoly, T; Bölcskei, K; Botz, B; Füredi, R; Pethő, G; Pintér, E; Szolcsányi, J | 1 |
| Chen, Y; Han, JS; Li, GX; Li, T; Liu, FY; Luo, H; Shi, YS; Wan, Y; Xing, GG; Xu, IS; Yang, F; Yu, L | 1 |
| Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I | 1 |
| Helmchen, C; Leyendecker, S; Machner, B; Mangels, I; Mohr, C; Sander, T | 1 |
| Bai, ZT; Cheng, M; Ji, YH; Jiang, F; Liu, T; Pang, XY | 1 |
| Blake, DR; Haigh, RC; Harris, N; Mapp, PI; Shenker, NG | 1 |
| Kissin, I | 1 |
| Eijkelkamp, N; Elsenbruch, S; Heijnen, CJ; Holtmann, G; Kavelaars, A; Schedlowski, M | 2 |
| Ballard, A; Bishop, T; Holmes, H; McMahon, SB; Young, AR | 1 |
| Bianchi, BR; Brown, BS; Faltynek, CR; Honore, P; Jarvis, MF; Keddy, R; Koenig, JR; Lee, CH; Marsh, KC; McDonald, HA; Polakowski, JS; Schmidt, RG; Surowy, CS; Zheng, GZ | 1 |
| Hu, JW; Lam, DK; Sessle, BJ | 1 |
| Alessandri-Haber, N; Bogen, O; Chen, X; Dina, OA; Green, PG; Khasar, SG; Levine, JD; Messing, RO; Reichling, DB | 1 |
| Huang, J; Wang, W | 1 |
| Evans, S; Fan, J; Hong, S; Kemmerer, ES; Li, Y; Wiley, JW | 1 |
| Baron, R; Binder, A | 1 |
| Carlton, SM; Du, J; Zhou, S | 1 |
| Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H | 1 |
| Lee, JS; Ro, JY; Zhang, Y | 2 |
| Gillardin, JM; Verleye, M | 1 |
| Baeyens, JM; Brenchat, A; Burgueño, J; Buschmann, H; García, M; Hamon, M; Pujol, M; Romero, L; Torrens, A; Vela, JM; Zamanillo, D | 1 |
| Chung, JM; Chung, K; Kim, HY; Klann, E; Lee, I; Schwartz, ES; Wang, J | 1 |
| Arendt-Nielsen, L; Gibson, W; Graven-Nielsen, T; Sessle, BJ | 1 |
| Bielefeldt, K; Christianson, JA; Davis, BM; Malin, SA | 1 |
| Fukushima, O; Ishikura, H; Kamanaka, Y; Kawabata, A; Matsunami, M; Naruse, M; Nishimura, S; Sekiguchi, F; Takahashi, T; Tsujiuchi, T | 1 |
| Furuyama, A; Jin, YH; Koike, Y; Takemura, M; Yamaki, F; Yonehara, N | 1 |
| Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL | 1 |
| Andersen, OK; Arendt-Nielsen, L; Hölzl, R; Kleinböhl, D; Stolle, AM; Trojan, J | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K | 1 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Del Pozo, E; Entrena, JM; Nieto, FR | 1 |
| Flühr, K; Lötsch, J; Neddermeyer, TJ | 1 |
| Andoh, T; Gauchan, P; Kato, A; Kuraishi, Y | 1 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Del Pozo, E; Entrena, JM; Gris, G; Nieto, FR; Zamanillo, D | 1 |
| Ahn, DK; Hong, SD; Jung, SJ; Kim, JS; Kim, K; Kim, MJ; Oh, SB; Park, CK | 1 |
| Arpey, C; Brennan, TJ; Hamalainen, MM; Subieta, A | 1 |
| Gál, V; Kóbor, I; Vidnyánszky, Z | 1 |
| Barrot, M; Charlet, A; Freund-Mercier, MJ; Poisbeau, P; Yalcin, I | 1 |
| Fitzgerald, M; Hathway, GJ; Ingram, R; Moss, A; Vega-Avelaira, D | 1 |
| Arendt-Nielsen, L; Brock, C; Drewes, AM; Olesen, AE; Staahl, C | 1 |
| Bastos, LC; Tonussi, CR | 1 |
| Gibson, SJ; Helme, RD; McMeeken, JM; Zheng, Z | 1 |
| Chichorro, JG; Motta, EM; Rae, GA | 1 |
| Cervero, F; Fernandez, C; Price, TJ; Sanoja, R; Tortorici, V | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Andresen, T; Arendt-Nielsen, L; Brock, C; Drewes, AM; Frøkjaer, JB; Gale, J; Olesen, AE | 1 |
| Cruikshank, JM; Gemes, G; Hogan, QH; Kawano, T; Rigaud, M; Weyker, PD; Wu, HE | 1 |
| Hammond, DL; Marquez de Prado, B; Russo, AF | 1 |
| Adam, B; Blackshaw, LA; Brierley, SM; Cooper, NJ; Corey, DP; Harrington, AM; Holtmann, G; Hughes, PA; Kwan, KY; Liebregts, T; Martin, CM; O'Donnell, TA; Page, AJ; Rychkov, GY | 1 |
| Chung, JM; Chung, K; Kim, HK; Kim, HY; Lee, I; Wang, J | 1 |
| Baggio, CH; Freitas, CS; Luiz, AP; Marcon, R; Nascimento, FP; Pizzolatti, MG; Santos, AR; Soldi, C; Werner, MF | 1 |
| Aasvang, EK; Hansen, JB; Kehlet, H | 1 |
| Hou, SX; Shang, WL; Tang, JG; Wu, WW | 1 |
| Akesson, J; Gustafsson, H; Lau, CL; Miller, L; Rolan, P; Williams, D; Yap, S | 1 |
| Calò, G; Guerrini, R; Hu, E; Ko, MC | 1 |
| Banik, RK; Brennan, TJ; Kang, S; Wu, C | 1 |
| Bent, LR; Dickey, JP; Lee, D; Lowerison, M; Srbely, JZ | 1 |
| Coghill, RC; Papoiu, AD; Patel, T; Wang, H; Wang, N; Yosipovitch, G | 1 |
| Brennan, TJ; Clark, DJ; Jang, JH; Li, X; Usachev, YM; Yorek, MS | 1 |
| Ahn, DK; Jung, SJ; Kim, HJ; Kim, JS; Kim, SA; Kim, YH; Lee, MK; Oh, SB; Yeon, KY | 1 |
| Blockey, P; Drummond, PD | 1 |
| Bastien, P; Breton, L; De Lacharrière, O; Jourdain, R; Maibach, HI | 1 |
| Bettoni, I; Comelli, F; Costa, B; Di Marzo, V; Giagnoni, G; Petrosino, S | 1 |
| Ghazi-Khansari, M; Jaberi, E; Mohammadi-Farani, A; Sahebgharani, M; Sepehrizadeh, Z | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X | 1 |
| Modir, JG; Wallace, MS | 1 |
| Meents, JE; Neeb, L; Reuter, U | 1 |
| Arendt-Nielsen, L; Lyngholm, AM; Petersen, LJ | 1 |
| Bhatnagar, A; Cuellar, JM; Klyukinov, M; Manering, NA; Niv, SH; Tzabazis, AZ; Yeomans, DC | 1 |
| Chen, SL; Dong, X; Fang, JY; Li, Y; Liu, ZL; Mo, JZ; Xiao, SD; Zhang, LY | 1 |
| Bian, ZX; Luo, JL; Qi, SD; Qin, HY; Sung, JJ; Xu, HX | 1 |
| Birklein, F; Fuchs, D; Reeh, PW; Sauer, SK | 1 |
| Arendt-Nielsen, L; Huang, L; Lei, J; Sui, MY; Tan, YX; Tjølsen, A; You, HJ | 1 |
| Arendt-Nielsen, L; Christrup, LL; Drewes, AM; Foster, DJ; Olesen, AE; Staahl, C; Upton, R | 1 |
| Lam, VY; Schulteis, G; Wallace, M | 1 |
| Akashi, R; Ishikura, H; Kawabata, A; Kitamura, T; Matsumura, K; Matsunami, M; Naruse, M; Nishimura, S; Sekiguchi, F; Shinozaki, Y | 1 |
| Bokrand-Donatelli, Y; Caudle, RM; Hester, J; Neubert, JK; Nolan, TA | 1 |
| Athayde, ML; de Oliveira, AP; Ferreira, J; Gomez, MV; Klafke, JZ; Rossato, MF; Royes, LF; Trevisan, G; Villarinho, JG; Walker, CI; Zanon, RB | 1 |
| Basbaum, AI; Edwards, RH; Harper, B; Hnasko, TS; Low, SA; Scherrer, G; Solorzano, C; Urban, R; Wang, X; Yamanaka, H; Zhang, J | 1 |
| Andresen, T; Arendt-Nielsen, L; Christrup, LL; Drewes, AM; Foster, DJ; Upton, RN | 1 |
| Drummond, PD; Knudsen, L | 1 |
| Andresen, T; Arendt-Nielsen, L; Drewes, AM; Mansikka, H; Oksche, A; Staahl, C | 1 |
| Bounds, SC; Campbell, CM; Campbell, JN; Edwards, RR; Haythornthwaite, JA; Simango, MB; Smith, MT; Witmer, KR | 1 |
| Chapman, H; Hao, B; Huang, JL; Koivisto, A; Kuokkanen, K; Pertovaara, A; Saarnilehto, M; Wang, YX; Wei, H | 1 |
| Hishida, R; Komagata, S; Shibuki, K; Takeshita, N; Tamaki, K | 1 |
| Arendt-Nielsen, L; Elberling, J; Holst, H; Mosbech, H | 1 |
| Cavazzini, A; De Siena, G; Failli, P; Gees, M; Geppetti, P; Harrison, S; Mancini, F; Marchetti, N; Materazzi, S; Moretto, N; Nassini, R; Nilius, B; Patacchini, R; Pedretti, P; Preti, D | 1 |
| Benoit, M; Chen, X; Gudermann, T; Hofmann, T; Janssens, A; Kerselaers, S; Nilius, B; Oberwinkler, J; Owsianik, G; Philipp, SE; Stab, J; Vennekens, R; Voets, T; Vriens, J; Xue, F | 1 |
| Largent-Milnes, TM; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV | 1 |
| Buschmann, H; Holenz, J; Köhler, J; Utech, T; Vela, JM; Wünsch, B | 1 |
| Goadsby, PJ; Kavantzas, N; Knight, YE; Lasalandra, M; Mitsikostas, DD | 1 |
| Abramova, A; Drdla, R; Ellmeier, W; Gaderer, S; Nuro, E; Sandkühler, J; Xanthos, DN | 1 |
| Bishnoi, M; Cao, DS; Evans, MS; Jeffry, JA; Pabbidi, RM; Pimentel, F; Premkumar, LS; Raisinghani, M; Zhong, L | 1 |
| Barabas, ME; Brandow, AM; Hillery, CA; Kerstein, PC; Retherford, D; Stucky, CL; Vilceanu, D; Wandersee, NJ | 1 |
| Aoki, T; Kiso, T; Matsuoka, N; Tsukamoto, M; Watabiki, T | 1 |
| Abernethy, L; Ansari, N; Cameron, K; Clarkson, T; Dempster, M; Dunn, D; Easson, AM; Edwards, D; Everett, K; Feilden, H; Ho, KK; Kultgen, S; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Neagu, I; Nimz, O; Nisbet, LA; Ohlmeyer, M; Palin, R; Pham, Q; Ratcliffe, P; Rong, Y; Roughton, A; Sammons, M; Swanson, R; Tracey, H; Walker, G | 1 |
| Aykanat, V; Briggs, N; Gentgall, M; Rolan, P; Williams, D; Yap, S | 1 |
| Jung, SS; Lee, SE; Shin, HK; Sung, KW | 1 |
| Chen, Y; Wang, ZJ; Yang, C | 1 |
| Bowles, WR; Burke, R; Harding-Rose, C; Hargreaves, KM; Lunos, S; Sabino, M | 1 |
| Draxler, J; Gustorff, B; Hauer, D; Seis, A; Thaler, J | 1 |
| Abooj, M; Bishnoi, M; Bosgraaf, CA; Premkumar, LS; Zhong, L | 1 |
| Green, BG; LaMotte, RH; Shimada, SG; Sikand, P | 1 |
| Ikoma, A; Steinhoff, M | 1 |
| Anand, P; Bley, K | 1 |
| Brock, C; Drewes, AM; Farina, D; Graversen, C | 1 |
| Bi, Y; Bian, X; Cao, X; Chen, H; Su, J; Wang, K | 1 |
| Beitz, AJ; Brink, TS; Khasabov, SG; Pacharinsak, C; Simone, DA | 1 |
| Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
| Beitz, AJ; Kang, SY; Lee, JH; Moon, JY; Park, JH; Roh, DH; Song, S; Yoon, SY | 1 |
| Finnerup, NB; Fuglsang-Frederiksen, A; Jensen, TS; Johnsen, B; Madsen, CS | 1 |
| Chen, PB; Hargreaves, KM; Loyd, DR | 1 |
| Alvarez, P; Brun, A; Constandil, L; Correa, A; Hernández, A; Labertrandie, A; Lopez, J; Pelissier, T | 1 |
| Benemei, S; Creminon, C; Fusi, C; Geppetti, P; Materazzi, S; Nassini, R; Nilius, B; Patacchini, R; Pedretti, P; Prenen, J | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Koyama, M; Kubo, A; Mizumura, K; Murase, S; Takagishi, Y; Tamura, R | 1 |
| Atsumi, E; Ishida, H; Kato, Y; Kodaira, H; Nakasato, Y; Saku, O; Shirakura, S; Sugimoto, Y | 1 |
| Helmchen, C; Leyendecker, S; Mohr, C; Petersen, D | 1 |
| Arendt-Nielsen, L; Elberling, J; Kupers, R; Tran, MT | 1 |
| Dolan, S; Graham, A; Iannitti, T | 1 |
| Funakubo, M; Iwashita, T; Koizumi, K; Kuroi, T; Sato, H; Shibata, M; Shimizu, T; Suzuki, N; Toriumi, H | 1 |
| Bevan, S; Culshaw, A; Fox, A; Groarke, A; Hallett, A; Lilley, E; McIntyre, P; Nash, MS; Panesar, M | 1 |
| Deai, K; Hamada, Y; Hayashi, M; Kitagawa, Y; Koga, Y; Matsushita, M; Miyai, A; Sakata, M; Tominaga, M; Usui, K; Wada, M | 1 |
| Comelli, F; Costa, B; D'Agostino, B; de Novellis, V; De Petrocellis, L; Di Marzo, V; Gatta, L; Guida, F; Luongo, L; Maione, S; Matteis, M; Sullo, N | 1 |
| Chi, XX; Li, C; Nicol, GD; Strong, JA; Xie, W; Zhang, JM | 1 |
| Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB | 1 |
| Hoeben, E; Mangold, B; Reitmeir, P; Rusch, S; Schaffler, K; Smit, JW; Upmalis, D | 1 |
| Cheng, J; Fox, LE; Shen, J | 1 |
| Duan, JH; Han, WJ; Hu, SJ; Luo, C; Miao, B; Sun, W; Wang, WT; Wang, XC; Ye, X | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Serra, J | 1 |
| Isami, K; Kaneko, S; Nakagawa, T; Nakamura, S; Shirakawa, H; Zhao, M | 1 |
| Cunha, JM; Jesus, CH; Neufeld, M; Schreiber, AK | 1 |
| Binshtok, AM; Hitomi, S; Iwata, K; Kitagawa, J; Lev, S; Maeda, T; Mostafeezur, RM; Seo, K; Suzuki, A; Suzuki, I; Yamada, Y; Yamamura, K; Zakir, HM | 1 |
| Brown, DT; Erichsen, HK; Hansen, RR; Mirza, NR; Munro, G | 1 |
| Baumbauer, KM; Grau, JW; Hughes, AJ; Lee, KH; Puga, DA; Woller, SA | 1 |
| Lam, V; Schettler, J; Wallace, MS | 1 |
| Ribeiro-da-Silva, A; Saeed, AW | 1 |
| Cervero, F; Nieto, FR; Pitcher, MH | 1 |
| Chung, MK; Ro, JY; Saloman, JL | 1 |
| Bavencoffe, A; Dessauer, CW; Efendiev, R; Hu, H; Zhu, MX | 1 |
| Bingel, U; Brooks, J; Lee, MC; Menon, DK; Ploner, M; Tracey, I; Wanigasekera, V; Wiech, K | 1 |
| Annas, P; Clarke, C; Huizar, K; Kalliomäki, J; Karlsten, R; Segerdahl, M; Zettergren, A | 1 |
| Andoh, T; Inomata, Y; Kuraishi, Y; Sasaki, A; Serizawa, K | 1 |
| Duan, B; Lou, S; Lowell, BB; Ma, Q; Vong, L | 1 |
| Cechinel Filho, V; de Campos Buzzi, F; Klein-Júnior, LC; Moreira, J | 1 |
| Belan, PV; Borisyuk, AL; Duzhyy, DE; Khomula, EV; Viatchenko-Karpinski, VY; Voitenko, NV | 1 |
| Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C | 1 |
| Itoh, H; Kawabata, A; Kawao, N; Kuroda, R; Shimada, C | 1 |
| Dahl, JB; Dirks, J; Petersen, KL; Rowbotham, MC | 1 |
| Gereau, RW; Yang, D | 1 |
| Chapman, V; Kelly, S | 1 |
| Andersen, OK; Arendt-Nielsen, L; Nielsen, J; Yucel, A | 1 |
| Casey, KL; Cross, DJ; Lorenz, J; Minoshima, S; Morrow, TJ; Paulson, PE | 1 |
| Arendt-Nielsen, L; Gibson, SJ; Graven-Nielsen, T; Laursen, RJ; Svensson, P | 1 |
| Bhave, G; Gereau, RW; Hu, HJ | 1 |
| Liu, XJ; Sawynok, J; White, TD | 1 |
| Anderson, WS; Bencherif, B; Campbell, JN; Frost, JJ; Sheth, RN | 1 |
| Growcott, J; Hughes, A; Macleod, A; Thomas, I | 1 |
| Barger, D; Schulteis, G; Wallace, MS | 1 |
| Cervero, F; Laird, JM; Souslova, V; Wood, JN | 1 |
| Curry, R; Eisenach, JC; Hood, DD | 5 |
| Ghilardi, JR; Khasabov, SG; Mantyh, PW; Peters, CM; Rogers, SD; Simone, DA | 1 |
| Fox, AJ; McIntyre, P; Medhurst, SJ; Panesar, M; Patel, S; Urban, L; Walker, KM | 1 |
| Calixto, JB; Ferreira, J; Santos, AR; Trentin, AP; Yunes, RA | 1 |
| Andersen, OK; Arendt-Nielsen, L; Drewes, AM; Sumikura, H | 2 |
| Appendino, G; Bisogno, T; Chu, CJ; Daddario, N; De Petrocellis, L; Di Marzo, V; Ewing, SA; Huang, SM; Miller, JD; Walker, JM; Zipkin, RE | 1 |
| Willis, WD | 2 |
| Bakoshi, S; Inoue, M; Kawashima, T; Kondo, S; Rashid, MH; Ueda, H | 1 |
| Engert, S; Forster, C; Klusch, A; Marín-Burgin, A; Petersen, M; Schwab, A; Wach, J | 1 |
| Spina, D | 1 |
| Dvorak, M; McGlone, F; Rukwied, R; Watkinson, A | 1 |
| Casey, KL; Lorenz, J; Minoshima, S | 1 |
| Li, GD; Zhao, ZQ; Zhou, Y | 1 |
| Cury, Y; Zanchet, EM | 1 |
| Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K | 1 |
| Bakoshi, S; Inoue, M; Rashid, MH; Ueda, H | 1 |
| Hamamoto, DT; Hodges, JS; Maccecchini, ML; Simone, DA; Turner, MS | 1 |
| Bach, FW; Gottrup, H; Jensen, TS; Kristensen, AD | 1 |
| Atweh, SF; Bach, JF; Dardenne, M; Jabbur, SJ; Saadé, NE; Safieth-Garabedian, B | 1 |
| Kline, RH; Vierck, CJ; Wiley, RG | 1 |
| Milke, P; Schmulson, MJ; Valdovinos, MA | 1 |
| Lawand, NB; Sun, RQ; Willis, WD | 1 |
| Arendt-Nielsen, L; Dimcevski, G; Drewes, AM; Funch-Jensen, P; Gregersen, H; Petersen, P; Schipper, KP | 1 |
| Foniok, T; Gregorash, L; Malisza, KL; Stroman, PW; Turner, A; Wright, A | 1 |
| Jarvis, MF | 1 |
| Barrett, AC; Picker, MJ; Smith, ES | 1 |
| Arendt-Nielsen, L; De Armas, L; Fiaschi, A; Le Pera, D; Maiese, T; Restuccia, D; Rosso, T; Tinazzi, M; Tonali, P; Valeriani, M | 1 |
| Auff, E; Eichler, HG; Gustorff, B; Lehr, S; Schmetterer, L; Schnider, P; Sycha, T; Voller, B | 1 |
| Farthing, JN; Hohmann, AG; Makriyannis, A; Zvonok, AM | 1 |
| Gaus, S; Kawamoto, M; Moriwaki, K; Suyama, H; Yuge, O | 1 |
| Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC | 1 |
| Dahl, JB; Dirks, J; Petersen, KL | 1 |
| Farquhar-Smith, WP; Rice, AS | 1 |
| Giesler, GJ; Honda, CN; LaMotte, RH; Li, J; Simone, DA; Zhang, JM; Zhang, X | 1 |
| Baad-Hansen, L; Jensen, TS; Svensson, P | 1 |
| Bostock, H; Campero, M; Ochoa, J; Serra, J | 1 |
| Ikeda, H; Kamanaka, Y; Kataoka, K; Kawabata, A; Kawao, N; Kitano, T; Kuroda, R; Sekiguchi, F | 1 |
| Bach, FW; Gottrup, H; Jensen, TS | 1 |
| Baamonde, A; Hidalgo, A; Lastra, A; Menéndez, L | 1 |
| Edwards, M; Schaffler, K; Seibel, K; Thomsen, M | 1 |
| Bíró, T; Blumberg, PM; Kovács, L; Lázár, J; Marincsák, R; Szabó, T | 1 |
| Amadesi, S; Bunnett, NW; Cottrell, GS; Davis, JB; Ennes, H; Geppetti, P; Grady, EF; Manni, C; Mayer, EA; McRoberts, JA; Nie, J; Trevisani, M; Vergnolle, N | 1 |
| Cervero, F; Delpire, EJ; García-Nicas, E; Laird, JM | 1 |
| Light, AR | 1 |
| Anand, KJ; Garg, S; Liu, JG; Rovnaghi, CR | 1 |
| Sun, RQ; Tu, Y; Willis, WD | 1 |
| Baamonde, A; Fresno, MF; Hidalgo, A; Lastra, A; Llames, S; Meana, A; Menéndez, L | 1 |
| Chen, JH; Dougherty, PM; Weng, HR | 1 |
| Andersen, OK; Arendt-Nielsen, L; Miyazawa, A; Yucel, A | 2 |
| Brückl, V; Gerdemann, U; Koppert, W; Märkert, D; Nassr, NA; Sittl, R | 1 |
| Forster, C; Handwerker, HO; Maihöfner, C; Neundörfer, B; Schmelz, M | 1 |
| Quessy, S; Schulteis, G; Wallace, MS | 1 |
| Lähdesmäki, J; Mansikka, H; Pertovaara, A; Scheinin, M | 1 |
| Atweh, SF; Jabbur, SJ; Massaad, CA; Poole, S; Saadé, NE; Safieh-Garabedian, B | 1 |
| Colleoni, M; Costa, B; Franke, C; Giagnoni, G; Trovato, AE | 1 |
| Arendt-Nielsen, L; De Armas, L; Le Pera, D; Maiese, T; Restuccia, D; Tinazzi, M; Tonali, P; Valeriani, M | 1 |
| Chakravarty, S; Dugar, S; Kerr, I; Ma, JY; Mangadu, R; Medicherla, S; Peters, MC; Protter, AA; Sweitzer, SM; Yeomans, DC | 1 |
| Clapham, DE; Ji, RR; Xu, H; Zhuang, ZY | 1 |
| Befort, K; Brenner, GJ; Ji, RR; Kawasaki, Y; Kohno, T; Van Der Meer, C; Wang, H; Woolf, CJ; Zhuang, ZY | 1 |
| Holzer, P | 1 |
| Fujita, T; Kamisaki, Y; Yonehara, N | 1 |
| Jones, CK; Peters, SC; Shannon, HE | 1 |
| Reitmeir, P; Schaffler, K | 1 |
| Cervero, F; Galan, A; Laird, JMA | 1 |
| Bach, FW; Brown, J; Chizh, BA; Gottrup, H; Jensen, TS; Juhl, G; Kristensen, AD; Lai, R | 1 |
| Beswick, PJ; Bingham, S; Bountra, C; Brown, T; Campbell, IB; Chessell, IP; Clayton, N; Collins, SD; Davey, PT; Goodland, H; Gray, N; Haslam, C; Hatcher, JP; Hunter, AJ; Lucas, F; Murkitt, G; Naylor, A; Pickup, E; Sargent, B; Stevens, A; Stratton, SC; Summerfield, SG; Wiseman, J | 1 |
| Cadiou, H; Jones, NG; McMahon, SB; McNaughton, P; Slater, R | 1 |
| Bannon, AW; Doherty, EM; Gavva, NR; Immke, D; Klionsky, L; Louis, JC; Norman, MH; Porreca, F; Qu, Y; Tamir, R; Treanor, JJ; Vanderah, TW; Wang, J; Wild, KD; Zhang, TJ; Zhu, D | 1 |
| Dai, Y; Fukuoka, T; Mashimo, T; Mizushima, T; Noguchi, K; Obata, K; Tokunaga, A; Yamanaka, H | 1 |
| Dahl, JB; Dirks, J; Duedahl, TH; Larsen, NE; Petersen, KB; Romsing, J | 1 |
| Casey, KL; Lorenz, J | 1 |
| Caterina, M; Cowan, A; Inan, S; Oppenheim, JJ; Rogers, TJ; Sun, R; Wang, JM; Zhang, N | 1 |
| Andersen, OK; Arendt-Nielsen, L; Eisenberg, E; Pud, D; Yarnitsky, D | 2 |
| Brooks, JCW; Iannetti, GD; Tracey, I; Wise, RG; Zambreanu, L | 1 |
| Iadarola, M; Karai, L; Lonser, RR; Olah, Z; Oldfield, EH; Tender, GC; Walbridge, S | 1 |
| Breese, NM; George, AC; Pauers, LE; Stucky, CL | 1 |
| Dougherty, PM; Weng, HR | 1 |
| El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ | 1 |
| Bach-Rojecky, L; Lacković, Z | 1 |
| Cervero, F; Galan, A | 1 |
| Dolan, RJ; Driver, J; Kalisch, R; Koltzenburg, M; Seymour, B; Stephan, KE; Wiech, K | 1 |
| Eggenreich, U; Gschanes, A; Reitmeir, P; Schaffler, K | 1 |
| Borrelli, E; Erbs, E; Mansikka, H; Pertovaara, A | 1 |
| Asai, H; Nagamine, K; Ozaki, N; Shinoda, M; Sugiura, Y; Tohnai, I; Ueda, M | 1 |
| Chapman, V; Kelly, S; Kendall, DA; Millns, PJ; O'Shaughnessey, CT; Sagar, DR | 1 |
| Arendt-Nielsen, L; Gazerani, P | 1 |
| Handwerker, HO; Maihöfner, C | 1 |
| Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G | 1 |
| Joshi, PG; Lakshmi, S | 1 |
| Jones, TL; Sorkin, LS | 1 |
| Baamonde, A; Hidalgo, A; Juarez, L; Lastra, A; Menéndez, L | 1 |
| Laurito, CE; Lu, Y; Pappas, GD; Peters, MC; Vota-Vellis, G; Wilson, SP; Yeomans, DC | 1 |
| Clapp, DW; Hingtgen, CM; Roy, SL | 1 |
| Hohmann, AG; Nackley, AG; Neely, MH; Piña, J | 1 |
| Buchanan, TJ; Huggins, JP; Iannetti, GD; Smart, TS; Tracey, I; Vennart, W; Wise, RG; Zambreanu, L | 1 |
| Andersen, OK; Arendt-Nielsen, L; Miyazawa, A; Sumikura, H; Yucel, A | 1 |
| Pöyhiä, R; Vainio, A | 1 |
| Sun, RQ; Tu, YJ; Willis, WD; Yan, JY | 1 |
| Chen, M; Gu, JG; Ling, J; Xing, H | 1 |
| Hammer, J | 1 |
| Jensen, MT; Petersen, KL | 1 |
| Beltramo, M; Bernardini, N; Bertorelli, R; Campanella, M; Fredduzzi, S; Nicolussi, E; Reggiani, A | 1 |
| Arendt-Nielsen, L; Chen, HS; Graven-Nielsen, T; He, X; Lei, J; Wang, Y; Wei, XZ; Wen, WW; You, HJ | 1 |
| Ishiki, T; Kanke, T; Kawabata, A; Kawao, N; Kitano, T; Masuko, T; Matsunami, M; Saito, N; Satoh, R | 1 |
| Caudle, RM; Malphurs, W; Neubert, JK; Rossi, HL; Vierck, CJ | 1 |
| Arendt-Nielsen, L; Drewes, AM; Gazerani, P; Staahl, C | 1 |
| Beneforti, P; Lazzeri, M; Malagutti, S; Spinelli, M; Turini, D | 1 |
| Baad-Hansen, L; Jensen, TS; List, T; Svensson, P | 1 |
| Castañeda-Hernandez, G; Lawand, NB; Lin, Q; Valencia-de Ita, S; Willis, WD | 1 |
| Balan, C; Bannon, AW; Bo, Y; Dominguez, C; Fotsch, C; Gavva, NR; Gore, VK; Klionsky, L; Ma, VV; Norman, MH; Ognyanov, VI; Qian, YX; Tamir, R; Treanor, JJ; Wang, X; Xi, N; Xu, S; Zhu, D | 1 |
| Bowles, WR; Harding-Rose, C; Hargreaves, KM; Sabino, M | 1 |
| Colucci, M; De Felice, M; Giannini, E; Lattanzi, R; Margheriti, F; Melchiorri, P; Negri, L; Porreca, F; Tian, H; Vellani, V | 1 |
| Amadesi, S; Barajas-Lopez, C; Bautista, F; Bunnett, NW; Chapman, K; Cottrell, GS; Divino, L; Grady, EF; Karanjia, R; Vanner, S; Vergnolle, N | 1 |
| Kuramasu, A; Mobarakeh, JI; Sakurada, S; Takahashi, K; Yanai, K | 1 |
| Alt, A; Bleakman, D; Dominguez, E; Iyengar, S; Jones, CK; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM | 1 |
| Chapman, V; Marsden, CA; Morris, PG; Moylan Governo, RJ; Prior, MJ | 1 |
| Imamura, Y; Iwata, K; Meng, ID; Ogawa, A; Ren, K | 1 |
| Capra, NF; Ro, JY | 1 |
| Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O | 1 |
| Ikemi, Y; Imagawa, T; Ito, S; Murakami, M; Ohta, T; Otsuguro, K | 1 |
| Albers, KM; Cornuet, P; Davis, BM; Frye, R; Koerber, HR; Malin, SA; Molliver, DC | 1 |
| Cichewicz, DL; Haller, VL; Welch, SP | 1 |
| Kumar, K; Polston, GR; Wallace, MS | 1 |
| Amaya, F; Barrett, L; Lin, CR; Samad, TA; Takada, J; Wang, H; Woolf, CJ | 1 |
| Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C | 1 |
| Ispirescu, JS; Scanlon, GC; Schulteis, G; Wallace, MS | 1 |
| Baad-Hansen, L; Brandsborg, B; Jensen, TS; Juhl, GI; Svensson, P | 1 |
| Frymoyer, AR; Petersen, KL; Rowbotham, MC | 1 |
| Baron, R; Chung, JM; Chung, K; Kim, HK; Lee, I; Schattschneider, J | 1 |
| Colleoni, M; Comelli, F; Costa, B; Giagnoni, G; Trovato, AE | 1 |
| Bradesi, S; Hicks, GA; Lao, L; Lee, K; Mayer, EA; McLean, PG; Winchester, WJ | 1 |
| Jang, JH; Kim, DW; Kim, KH; Lee, WT; Leem, JW; Nam, TS; Park, KA | 1 |
| Arendt-Nielsen, L; Chen, HS; He, X; Wang, Y; Wen, WW; You, HJ | 1 |
| Barrett, AC; Lomas, LM; Lysle, DT; Picker, MJ; Terner, JM | 1 |
| Baron, R; Binder, A; Hedderich, J; Schattschneider, J; Wasner, G; Zum Buttel, I | 1 |
| Dai, Y; Fukuoka, T; Katsura, H; Kobayashi, K; Mashimo, T; Mizushima, T; Noguchi, K; Obata, K; Sakurai, J; Yamanaka, H | 1 |
| Medley, D; Naniwadekar, A; Pasricha, PJ; Shenoy, M; Winston, J | 1 |
| Chung, K; Gao, X; Kim, HK; Mo Chung, J | 1 |
| Finnerup, NB; Jensen, TS; Johannesen, IL; Pedersen, LH; Terkelsen, AJ | 1 |
| Chung, JM; Chung, K; Kim, HK; Kim, JH; Lee, I | 1 |
| Aiello-Lammens, M; Becerra, L; Borsook, D; Morris, S; Moulton, EA; Pendse, G; Strassman, A | 1 |
| Birklein, F; Fondel, R; Geber, C; Krämer, HH; Rolke, R; Sommer, C; Treede, RD | 1 |
| Althaus, M; Hanschmann, A; Klein, T; Magerl, W; Treede, RD | 1 |
| Bigalke, H; Blersch, W; May, A; Opatz, O; Schulte-Mattler, WJ; Wohlfahrt, K | 1 |
| Baron, R; Naleschinski, D; Wasner, G | 1 |
| Benedek, G; Horvath, G; Kekesi, G; Nagy, E | 1 |
| Gyires, K; Helyes, Z; László, J; Sándor, K; Szolcsányi, J | 1 |
| Fuchs, A; Hogan, QH; Rigaud, M | 1 |
| Amadesi, S; Bunnett, NW; Chapman, K; Cottrell, GS; Gedda, K; Hollenberg, MD; Knecht, W; Mohlin, J; Peterson, A; Skåregärde, A; Vergnolle, N | 1 |
| Pasricha, PJ; Pendyala, S; Shenoy, M; Winston, JH; Xu, GY; Yin, H | 1 |
| Banerjee, B; Mannem, A; Miranda, A; Nordstrom, E; Sengupta, JN; Smith, C | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
| Capra, NF; Lee, J; Ro, JY; Zhang, Y | 1 |
| Birchmeier, C; Erdmann, B; Frahm, C; Garratt, AN; Gassmann, M; Griffel, C; Lewin, GR; Milenkovic, N | 1 |
| Abramson, I; Atkinson, JH; Bentley, H; Gouaux, B; Lazzaretto, D; Schulteis, G; Wallace, M; Wolfson, T | 1 |
| Chen, M; Gu, JG; Ling, J; Tan, W; Xing, H | 1 |
| Chen, HS; Hou, S; Tang, JG; Wang, X; Yuan, W; Zhou, X | 1 |
| Abu-Asab, M; Iadarola, MJ; Jenkins, AC; Karai, LJ; Mannes, AJ; Neubert, JK; Zawatski, L | 1 |
| Knotkova, H; Pappagallo, M; Szallasi, A | 1 |
| Chiang, H; Hsieh, ST; Hsieh, YL; Tseng, TJ | 1 |
| Lomas, LM; Picker, MJ; Terner, JM | 1 |
| Brand, A; Erdmann, B; Heppenstall, PA; Hu, J; Jüttner, R; Laurito, CE; Lewin, GR; Lu, Y; Milenkovic, N; Park, TJ; Smith, ES; Wetzel, C; Wilson, SP | 1 |
| Hwang, SJ; Kim, E; Kim, J; Kim, SM; Lee, SE; Shin, HK | 1 |
| Engert, S; Petersen, M; Schwab, A; Wendland, JR | 1 |
| Helmchen, C; Leyendecker, S; Mohr, C | 1 |
| Chung, K; Lee, I; Mo Chung, J; Schwartz, ES | 1 |
| Beitz, AJ; Khasabov, SG; Pacharinsak, C; Simone, DA | 1 |
| Bautista, D; Julius, D | 1 |
| Hironaka, K; Ogino, A; Ozaki, N; Shinoda, M; Sugiura, Y; Urano, H; Yasui, M | 1 |
| Andratsch, M; Bluethmann, H; Blumer, MJ; Constantin, CE; Davis, JB; Ji, RR; Kress, M; Mair, N; Sailer, CA; Scherbakov, N; Xu, ZZ | 1 |
| Furuse, S; Ji, W; Kawamata, T; Namiki, A; Niiyama, Y; Yamamoto, J | 1 |
| Brennan, TJ; Gavva, NR; Wu, C | 1 |
| Bevan, S; Campbell, EA; Winter, J | 1 |
| Drummond, PD | 7 |
| Kinnman, E; Levine, JD | 1 |
| Handwerker, HO; Ringkamp, M; Schmelz, M; Schmidt, R; Torebjörk, HE | 1 |
| Dubner, R; Ren, K; Ruda, MA; Williams, GM | 1 |
| Campbell, JN; Cervero, F; Meyer, RA | 1 |
| Handwerker, HO; Kilo, S; Koltzenburg, M; Schmelz, M | 1 |
| Andreev, N; Dray, A; Urban, L | 1 |
| Davis, A; Perkins, MN | 1 |
| Risberg, T; Wist, E | 1 |
| Cole, JD; Treede, RD | 1 |
| Brune, K; Forster, C; Geisslinger, G; Handwerker, HO; Kilo, S | 1 |
| Andersen, OK; Arendt-Nielsen, L; Gracely, RH | 1 |
| Gold, MS; Levine, JD; Reichling, DB; Shuster, MJ | 1 |
| Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E | 1 |
| Campbell, JN; Davis, KD; Filloon, TG; Meyer, RA; Pappagallo, M; Turnquist, JL | 1 |
| Andersen, OK; Arendt-Nielsen, L; Jensen, TS | 1 |
| Cervero, F; Laird, JM | 1 |
| Bennett, GJ; Gracely, RH; Max, MB; Sang, CN | 1 |
| Andersen, OK; Arendt-Nielsen, L; Bjerring, P; Felsby, S; Jensen, TS; Nicolaisen, L | 1 |
| Davis, AJ; Perkins, MN | 1 |
| Kress, M; Schmelz, M | 1 |
| Allard, BL; Gilchrist, HD; Simone, DA | 1 |
| Bennett, GJ; Liu, M; Max, MB; Parada, S; Rowan, JS | 1 |
| Ali, Z; Campbell, JN; Meyer, RA | 1 |
| Laitin, S; Licht, D; Wallace, MS; Yaksh, TL | 1 |
| Curry, R; Eisenach, JC; Hood, DD; Tong, C | 1 |
| Sluka, KA | 2 |
| Cruwys, SC; Kidd, BL; Morris, VH | 1 |
| Bushnell, MC; Chen, CC; Kupers, RC | 1 |
| Vandam, LD | 1 |
| Allen, BJ; Daughters, RS; Ghilardi, JR; Honore, P; Lappi, DA; Li, J; Mantyh, PW; Rogers, SD; Simone, DA; Wiley, RG | 1 |
| Mansikka, H; Pertovaara, A | 1 |
| Bunnett, NW; Grady, EF; Martínez, V; Marvizón, JC; Mayer, EA | 1 |
| Cruwys, S; Garrett, NE; Malcangio, M; Tomlinson, DR | 1 |
| Ishikawa, T; Menniti, FS; Mizutani, M; Nagahisa, A; Shimada, K; Shinjo, K; Taniguchi, K | 1 |
| Alleva, E; Aloe, L; Cirulli, F; De Acetis, L; Padoa Schioppa, C | 1 |
| Magerl, W; Treede, RD; Wilk, SH | 1 |
| Hargreaves, KM; Kilo, S; Richardson, JD | 1 |
| Lin, Q; McAdoo, DJ; Willis, WD; Wu, J | 1 |
| Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR | 1 |
| Andersen, OK; Arendt-Nielsen, L; Mohammadian, P | 1 |
| Bennett, GJ; Gracely, R; Liu, M; Max, MB; Sethna, NF | 1 |
| Andersen, OK; Arendt-Nielsen, L; Kauppila, T; Mohammadian, P; Nielsen, J | 1 |
| D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Tonussi, CR | 1 |
| Bennett, GJ; Gracely, RH; Liu, M; Max, MB; Robinovitz, E | 1 |
| Cruwys, S; Kidd, B; Morris, V | 1 |
| Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA | 1 |
| Arendt-Nielsen, L; Jensen, TS; Svensson, P; Witting, N | 2 |
| Dougherty, MP; Lenz, AF; Willis, DW | 1 |
| Caruso, R; Chappell, AS; Gracely, RH; Hostetter, MP; Lee, G; Max, MB; Sang, CN; Schoepp, DD; Whitcup, S | 1 |
| Michael, LR; Southall, DM; Vasko, RM | 1 |
| Kuraishi, Y; Sasaki, M; Tohda, C | 1 |
| Atweh, SF; Jabbur, SJ; Kanaan, SA; Major, SC; Saadé, NE; Safieh-Garabedian, B | 1 |
| Campero, M; Ochoa, J; Serra, J | 1 |
| Kemper, RHA; Meijler, WJ; Spoelstra, MB; Ter Horst, GJ | 1 |
| Hwang, SW; Jung, JY; Kwak, JY; Lee, WT; Oh, U | 1 |
| Hamilton, SG; McMahon, SB; Wade, A | 1 |
| Bian, D; Lai, J; Malan, TP; Ossipov, MH; Porreca, F | 1 |
| Cui, M; Lin, Q; Palecek, J; Palecková, V; Peng, YB; Willis, WD; Wu, J | 1 |
| Baron, R; Binder, A; Borgstedt, R; Fields, HL; Hastedt, E; Kopper, F; Levine, JD; Rowbotham, M; Schulte, H; Wasner, G | 1 |
| Maibach, HI; Rowbotham, MC; Yosipovitch, G | 1 |
| Andrews, K; Baranowski, A; Kinnman, E | 1 |
| Bengiamin, R; Brennan, J; Bullis, C; Daughters, RS; Li, J; Simone, DA; Stucky, MW | 1 |
| Mansikka, H; Raja, SN; Shiotani, M; Winchurch, R | 1 |
| Kamei, J; Ohsawa, M | 2 |
| Petersen, KL; Rowbotham, MC | 1 |
| Cesare, P; McNaughton, PA; Moriondo, A; Vellani, V | 1 |
| Mendell, LM; Shu, XQ | 1 |
| Baron, R; Baron, Y; Disbrow, E; Roberts, TP | 2 |
| Bennett, GJ; Byas-Smith, MG; Dubner, R; Gracely, RH; Max, MB; Robinovitz, E | 1 |
| Calixto, JB; Ferreira, J; Santos, AR | 1 |
| Bramwell, S; Field, MJ; Hughes, J; Singh, L | 1 |
| Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ | 1 |
| Magerl, W; Meyer, RA; Treede, RD; Ziegler, EA | 1 |
| Blunk, JA; Koppert, W; Likar, R; Schmelz, M; Sittl, R; Zeck, S | 1 |
| Calixto, JB; Filho, VC; Malheiros, A; Mendes, GL; Santos, AR; Yunes, RA | 1 |
| Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J | 1 |
| Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH | 1 |
| Campbell, JN; Fuchs, PN; Meyer, RA | 1 |
| Baron, R; Binder, A; Kopper, F; Wasner, G | 1 |
| Handwerker, HO; Schmelz, M; Schmid, R; Torebjörk, HE | 1 |
| Gibson, SJ; Helme, RD; Khalil, Z; McMeeken, JM; Zheng, Z | 1 |
| Koppert, W; Ostermeier, N; Schmelz, M; Sittl, R; Weidner, C | 1 |
| D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Souza, GE | 1 |
| Arendt-Nielsen, L; Gottrup, H; Hansen, PO; Jensen, TS | 1 |
| Ali, Z; Campbell, JN; Huang, JH; Meyer, RA; Travison, TG | 1 |
| Hargreaves, KM; Kehl, LJ; Trempe, TM | 1 |
| Atkinson, K; Bingham, S; Clapham, C; Davey, PT; Davis, JB; Grau, E; Gray, J; Gunthorpe, MJ; Harper, AJ; Harries, MH; Hatcher, JP; Hughes, SA; Latcham, J; Overend, P; Pugh, PL; Rance, K; Randall, A; Rogers, DC; Sheardown, SA | 1 |
| Bhattacharjee, A; Hamilton, SG; McMahon, SB; Warburton, J; Ward, J | 1 |
| Southall, MD; Vasko, MR | 1 |
| Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C | 1 |
| Inoue, K; Kita, A; Koizumi, S; Shigemoto, Y; Tsuda, M; Ueno, S | 1 |
| Dahl, JB; Dirks, J; Fabricius, P; Petersen, KL; Rowbotham, MC | 1 |
| Baron, R | 1 |
| Kamei, J; Zushida, K | 2 |
| Cirillo, R; Evangelista, S; Lippi, A; Maggi, CA; Manzini, S; Terracciano, R; Vieira, C | 1 |
| Arendt-Nielsen, L; Bach, FW; Gottrup, H; Jensen, TS | 1 |
| Buchheit, KH; Campbell, EA; Chaudhry, N; James, IF; Kane, S; Panesar, M; Patel, S; Sandells, B; Urban, L | 1 |
| Dahl, JB; Jones, B; Petersen, KL; Rowbotham, MC; Segredo, V | 1 |
| Arnold, MA; Patterson, SL; Sluka, KA | 1 |
| Jaggar, SI; James, IF; Rice, AS; Scott, HC | 1 |
| Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Roza, C | 1 |
| Brandt, MR; Furness, MS; Mello, NK; Negus, SS; Rice, KC | 1 |
| Inoue, K; Koizumi, S; Tsuda, M | 1 |
| Itoh, M; Konemura, T; Kuraishi, Y; Sasaki, M; Sasamura, T; Tohda, C | 1 |
| Chen, HS; Chen, J | 1 |
| Masu, M; Tominaga, M; Wada, M | 1 |
| Cervero, F; Garcia-Nicas, E; Laird, JMA; Martinez-Caro, L | 1 |
| Sluka, KA; Wright, A | 1 |
| Gillard, SE; Hammond, DL; Hurley, RW; Miller, RJ; Oh, SB; Tran, PB | 1 |
| Benrath, J; Gillardon, F; Zimmermann, M | 1 |
| Heitmiller, DR; Hodges, J; Johanek, LM; Nader, N; Simone, DA; Turner, M | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Fuchs, PN; Magerl, W; Meyer, RA; Treede, RD | 1 |
| Elde, R; Fairbanks, CA; Guo, A; Simone, DA; Stone, LS; Wang, J | 1 |
| Drummond, PD; Lipnicki, DM | 1 |
| Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH | 1 |
| Blockey, P; Drummond, PD; Finch, PM; Skipworth, S | 1 |
| Chung, JM; Kim, HT; Lee, DH; Lee, SE; Park, SK | 1 |
| Ma, QP | 1 |
| Cervero, F; Garcia-Nicas, E; Laird, JMA | 1 |
| Baranowski, AP; Harding, LM; Kinnman, E; Murphy, A | 1 |
| Agashe, GS; Clark, JD; Davies, MF; Guo, TZ; Kingery, WS; Maze, M | 1 |
| Leung, A; Ridgeway, B; Schulteis, G; Wallace, MS; Yaksh, TL | 1 |
| Belmonte, C; Caprini, M; Carbonell, T; De Felipe, C; De La Pena, E; Ferrer-Montiel, A; García-Martinez, C; Gomis, A; Humet, M; Messeguer, A; Pérez-Paya, E; Planells-Cases, R; Sanchez-Baeza, F; Viana, F | 1 |
| Doom, CM; Junger, H; Sorkin, LS; Yu, AL | 1 |
| Hama, AT | 1 |
| Baumgärtner, U; Hopf, HC; Klein, T; Magerl, W; Treede, RD | 1 |
| Bradley, EL; Bright, CA; Kissin, I | 1 |
| Fang, L; Lin, Q; Willis, WD; Wu, J | 1 |
| Adhikari, SM; Kokayeff, A; Lariviere, WR; Laughlin, TM; Mogil, JS; Wan, Y; West, EE; Wilson, SG | 1 |
| Al-Hayani, A; Bisogno, T; Chu, CJ; Davies, SN; De Petrocellis, L; Di Marzo, V; Fezza, F; Geppetti, P; Huang, SM; Krey, JF; Miller, JD; Petros, TJ; Tognetto, M; Trevisani, M; Walker, JM | 1 |
| Hylden, JL; Noguchi, K; Ruda, MA | 1 |
| Campbell, EA; Perkins, MN | 1 |
| Campbell, JN; Meyer, RA; Raja, SN; Treede, RD | 1 |
| LaMotte, RH; Lundberg, LE; Torebjörk, HE | 2 |
| Brenton, W; Carr, RW; Delaney, CA; Kiln, JC; Pano, I; Rabavilas, A; Roberts, RG; Westerman, RA | 1 |
| LaMotte, RH; Shain, CN; Simone, DA; Tsai, EF | 1 |
| Baumann, TK; LaMotte, RH; Shain, CN; Simone, DA | 1 |
| Chung, JM; LaMotte, RH; Oh, U; Owens, C; Simone, DA; Sorkin, LS; Willis, WD | 1 |
| Barthó, L; Herz, A; Stein, C | 1 |
| Seltzer, Z; Shir, Y | 1 |
| Baumann, TK; LaMotte, RH; Simone, DA | 1 |
| Cline, M; Culp, WJ; Dotson, R; Ochoa, J | 1 |
| Nagy, JI; van der Kooy, D | 1 |
| Coderre, TJ; Melzack, R | 1 |
18 review(s) available for capsaicin and Allodynia
| Article | Year |
|---|---|
Nobel somatosensations and pain.
Topics: Capsaicin; Humans; Hyperalgesia; Ion Channels; Nobel Prize; Pain; Temperature; TRPA1 Cation Channel; TRPV Cation Channels | 2022 |
Human surrogate models of central sensitization: A critical review and practical guide.
Topics: Animals; Capsaicin; Central Nervous System Sensitization; Humans; Hyperalgesia; Neuralgia; Pain Measurement | 2021 |
Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity.
Topics: Analgesia; Analgesics; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Nerve Fibers; Neural Conduction; Pain, Postoperative; Rats; TRPV Cation Channels | 2008 |
TRPV1 in migraine pathophysiology.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Female; Humans; Hyperalgesia; Male; Mice; Migraine Disorders; Nociceptors; Rats; Trigeminal Ganglion; TRPV Cation Channels; United States | 2010 |
Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch.
Topics: Administration, Topical; Analgesics; Animals; Capsaicin; Humans; Hyperalgesia; Nociceptors; Pain | 2011 |
Intestinal gas: has diet anything to do in the absence of a demonstrable malabsorption state?
Topics: Capsaicin; Diet; Dietary Carbohydrates; Dietary Fiber; Enterobacteriaceae; Gases; Humans; Hyperalgesia; Intestinal Diseases; Intestines; Irritable Bowel Syndrome; Malabsorption Syndromes; Prebiotics; Probiotics | 2012 |
Long-term potentiation in spinothalamic neurons.
Topics: Animals; Capsaicin; Excitatory Amino Acids; Humans; Hyperalgesia; Long-Term Potentiation; Nerve Net; Neurotransmitter Agents; Phosphorylation; Receptors, Glutamate; Receptors, Neurotransmitter; Second Messenger Systems; Spinal Cord; Thalamus | 2002 |
A comparison of the pharmacological modulation of hyperalgesia and bronchial hyperresponsiveness.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Capsaicin; Humans; Hyperalgesia; Narcotics; Receptors, N-Methyl-D-Aspartate | 2003 |
Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain.
Topics: Acute Disease; Adenosine Triphosphate; Afferent Pathways; Analgesics; Animals; Biopolymers; Capsaicin; Chronic Disease; Ganglia, Spinal; Gene Targeting; Humans; Hyperalgesia; Mice; Mice, Knockout; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Neurons; Nociceptors; Pain; Phenotype; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X3 | 2003 |
TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia.
Topics: Animals; Capsaicin; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Hyperalgesia; Ion Channel Gating; Receptors, Drug | 2004 |
Imaging of acute versus pathological pain in humans.
Topics: Acute Disease; Adult; Brain; Capsaicin; Humans; Hyperalgesia; Male; Pain; Physical Stimulation; Positron-Emission Tomography; Reference Values | 2005 |
Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival?
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Drug Administration Routes; Humans; Hyperalgesia; Molecular Structure; Pain, Intractable; Sensory System Agents; TRPV Cation Channels | 2008 |
Capsaicin and pain mechanisms.
Topics: Analgesia; Animals; Capsaicin; Drug Resistance; Humans; Hyperalgesia; Nerve Degeneration; Nociceptors; Pain; Receptors, Drug | 1995 |
Ion channels gated by heat.
Topics: Animals; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ion Channel Gating; Ion Channels; Nociceptors; Pain | 1999 |
Neurotrophins and hyperalgesia.
Topics: Adult; Animals; Capsaicin; Ganglia, Spinal; Humans; Hyperalgesia; Nerve Growth Factors; Neurons; Nociceptors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Receptors, Drug; Receptors, Nerve Growth Factor | 1999 |
[ATP receptors in pain].
Topics: Adenosine Triphosphate; Animals; Capsaicin; Electrophysiology; Ganglia, Spinal; Humans; Hyperalgesia; Nociceptors; Pain; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Signal Transduction | 2000 |
Role of neurotransmitters in sensitization of pain responses.
Topics: Animals; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Agonists; Haplorhini; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Long-Term Potentiation; Mechanoreceptors; Microdialysis; Models, Animal; Models, Neurological; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Processing, Post-Translational; Rats; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Signal Transduction; Spinothalamic Tracts; Substance P | 2001 |
Peripheral and central mechanisms of cutaneous hyperalgesia.
Topics: Animals; Capsaicin; Humans; Hyperalgesia; Mustard Plant; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Nociceptors; Physical Stimulation; Plant Extracts; Plant Oils; Rats; Skin; Skin Diseases; Skin Temperature; Spinothalamic Tracts | 1992 |
126 trial(s) available for capsaicin and Allodynia
| Article | Year |
|---|---|
Sumatriptan prevents central sensitization specifically in the trigeminal dermatome in humans.
Topics: Capsaicin; Central Nervous System Sensitization; Headache; Humans; Hyperalgesia; Migraine Disorders; Pain; Sumatriptan; Tryptamines | 2022 |
A randomized, double-blinded, placebo-controlled, crossover study of the HCN channel blocker ivabradine in a capsaicin-induced pain model in healthy volunteers.
Topics: Adult; Analgesics; Calcium Channel Blockers; Capsaicin; Cross-Over Studies; Female; Healthy Volunteers; Humans; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ivabradine; Male; Neuralgia; Nucleotides, Cyclic | 2022 |
A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pregabalin; Young Adult | 2020 |
Anodal transcranial direct current stimulation over the primary motor cortex attenuates capsaicin-induced dynamic mechanical allodynia and mechanical pain sensitivity in humans.
Topics: Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Motor Cortex; Transcranial Direct Current Stimulation | 2020 |
A novel computational technique for the quantification of temporal summation in healthy individuals.
Topics: Capsaicin; Central Nervous System Sensitization; Chronic Pain; Humans; Hyperalgesia; Pain Measurement | 2021 |
Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain.
Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Male; Pain; Pregabalin | 2021 |
Capsaicin 8% Patch Repeat Treatment in Nondiabetic Peripheral Neuropathic Pain: A 52-Week, Open-Label, Single-Arm, Safety Study.
Topics: Aged; Analgesics, Non-Narcotic; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Prospective Studies; Reflex; Sensation; Transdermal Patch; Treatment Outcome | 2017 |
Superiority of capsaicin 8% patch versus oral pregabalin on dynamic mechanical allodynia in patients with peripheral neuropathic pain.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Pregabalin; Treatment Outcome; Young Adult | 2018 |
The Effect of a Combination of Diclofenac and Methadone Applied as Gel in a Human Experimental Pain Model - A Randomized, Placebo-controlled Trial.
Topics: Administration, Cutaneous; Adult; Capsaicin; Chronic Pain; Cross-Over Studies; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Gels; Healthy Volunteers; Humans; Hyperalgesia; Injections, Intradermal; Male; Methadone; Middle Aged; Nerve Growth Factor; Pain Measurement; Placebos; Treatment Outcome; Young Adult | 2018 |
PIEZO2 mediates injury-induced tactile pain in mice and humans.
Topics: Animals; Capsaicin; Chronic Disease; Disease Models, Animal; Humans; Hyperalgesia; Imaging, Three-Dimensional; Inflammation; Ion Channels; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neurons; Pain; Recombination, Genetic; Touch | 2018 |
TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.
Topics: Acrolein; Adult; Capsaicin; Cold Temperature; Cross-Over Studies; Female; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Male; Menthol; Neuralgia; Pain Threshold; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels; Young Adult | 2019 |
Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Endotoxins; Humans; Hyperalgesia; Male; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Toll-Like Receptor 4 | 2013 |
Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Edema; Furans; Ginkgolides; Hindlimb; Hyperalgesia; Inflammation; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sensory System Agents; Vocalization, Animal | 2013 |
Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method.
Topics: Adult; Analgesics; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Threshold; Pregabalin; Young Adult | 2014 |
Bilateral hypersensitivity to capsaicin, thermal, and mechanical stimuli in unilateral complex regional pain syndrome.
Topics: Administration, Topical; Adolescent; Adult; Aged; Capsaicin; Complex Regional Pain Syndromes; Female; Hot Temperature; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Middle Aged; Pain Measurement; Young Adult | 2014 |
Effect of written emotional disclosure on secondary hyperalgesia in women with trauma history.
Topics: Adolescent; Adult Survivors of Child Abuse; Bereavement; Capsaicin; Central Nervous System Sensitization; Depression; Disasters; Emotions; Female; Humans; Hyperalgesia; Irritants; Pain; Self Disclosure; Social Problems; Stress, Psychological; Survivors; Wounds and Injuries; Writing; Young Adult | 2014 |
Repetitive transcranial magnetic stimulation over primary motor vs non-motor cortical targets; effects on experimental hyperalgesia in healthy subjects.
Topics: Adolescent; Adult; Brain; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Motor Cortex; Pain Threshold; Sensory System Agents; Transcranial Magnetic Stimulation; Young Adult | 2014 |
Spinal fMRI reveals decreased descending inhibition during secondary mechanical hyperalgesia.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Neuralgia; Pontine Tegmentum; Radiography; Spinal Cord | 2014 |
A randomized, double-blind, crossover study to evaluate the depth response relationship of intradermal capsaicin-induced pain and hyperalgesia in healthy adult volunteers.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Sensory System Agents; Young Adult | 2015 |
Altered thermal grill response and paradoxical heat sensations after topical capsaicin application.
Topics: Adolescent; Adult; Anxiety; Capsaicin; Female; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Sensory System Agents; Statistics, Nonparametric; Surveys and Questionnaires; Thermosensing; Young Adult | 2015 |
Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development.
Topics: Adult; Amines; Analgesics; Analgesics, Non-Narcotic; Brain; Capsaicin; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Ibuprofen; Magnetic Resonance Imaging; Male; Neuroimaging; Reproducibility of Results; Treatment Outcome; Young Adult | 2016 |
Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.
Topics: Adolescent; Adult; Aged; Capsaicin; Electric Stimulation; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Psychophysics; Skin; Young Adult | 2016 |
Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects.
Topics: Administration, Intravenous; Adult; Affect; Breath Tests; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Ethanol; Female; Humans; Hyperalgesia; Male; Young Adult | 2016 |
Evaluation of the antihyperalgesic effect of tapentadol in two human evoked pain models - the TapCapMentho pilot trial.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Neuralgia; Pain; Pain Measurement; Pain Threshold; Phenols; Pilot Projects; Tapentadol; Young Adult | 2016 |
Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study.
Topics: Adolescent; Adult; Analgesics; Capsaicin; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Pentoxifylline; Sensory System Agents; Tourniquets; Young Adult | 2016 |
Agreement between quantitative and qualitative sensory testing of changes in oro-facial somatosensory sensitivity.
Topics: Adult; Capsaicin; Cross-Over Studies; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Mouth; Pain Measurement; Pain Threshold; Physical Stimulation; Sensory System Agents | 2017 |
Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects.
Topics: Adolescent; Adult; Alkaloids; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Drug Administration Routes; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Hypnotics and Sedatives; Injections, Intradermal; Injections, Intravenous; Male; Middle Aged; Morphine; Pain; Pain Measurement; Placebos; Pregabalin; Treatment Outcome; Young Adult | 2008 |
Capsaicin or menthol sensitization induces quantitative but no qualitative changes to thermal and mechanical pain thresholds.
Topics: Adolescent; Adult; Antipruritics; Capsaicin; Female; Humans; Hyperalgesia; Male; Menthol; Middle Aged; Pain Measurement; Pain Threshold; Physical Stimulation; Young Adult | 2009 |
Evoked human oesophageal hyperalgesia: a potential tool for analgesic evaluation?
Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Esophagus; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Reproducibility of Results | 2009 |
The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study.
Topics: Adult; Aged; Aging; Analysis of Variance; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesia; Lidocaine; Male; Pain Measurement; Personality; Procaine; Psychophysics; Sex Factors; Time Factors; Young Adult | 2009 |
Late sensory function after intraoperative capsaicin wound instillation.
Topics: Adolescent; Adult; Aged; Analgesics; Capsaicin; Double-Blind Method; Follow-Up Studies; Hernia, Inguinal; Humans; Hyperalgesia; Instillation, Drug; Intraoperative Care; Male; Middle Aged; Nerve Fibers; Pain Measurement; Pain Threshold; Pain, Postoperative; Placebos; Pressure; Sensation; Sensory System Agents; Sensory Thresholds; Surgical Mesh; Thermosensing; Touch; Treatment Outcome; Young Adult | 2010 |
A comparison of two formulations of intradermal capsaicin as models of neuropathic pain in healthy volunteers.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adult; beta-Cyclodextrins; Capsaicin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Excipients; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Sensory System Agents; Sex Factors; Single-Blind Method; Skin; Time Factors; Young Adult | 2009 |
Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans.
Topics: Administration, Topical; Adult; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Muscle, Skeletal; Myofascial Pain Syndromes; Pain Measurement; Pain Threshold; Physical Stimulation; Placebo Effect; Sensory Receptor Cells; Sensory System Agents; Young Adult | 2010 |
Ethnic variations in facial skin neurosensitivity assessed by capsaicin detection thresholds.
Topics: Administration, Cutaneous; Adolescent; Adult; Asian People; Black People; Capsaicin; Dose-Response Relationship, Drug; Face; Female; Humans; Hyperalgesia; Irritants; Nociceptors; Sensory Thresholds; Single-Blind Method; Skin; Statistics, Nonparametric; White People | 2009 |
A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate.
Topics: Adult; Capsaicin; Dermatitis, Contact; Humans; Hyperalgesia; Irritants; Male; Pain; Skin; Sodium Dodecyl Sulfate | 2010 |
A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia.
Topics: Acids; Administration, Oral; Adult; Analgesics, Opioid; Capsaicin; Cross-Over Studies; Double-Blind Method; Esophagus; Female; Humans; Hyperalgesia; Male; Middle Aged; Models, Biological; Oxycodone; Pain Measurement; Time Factors; Young Adult | 2010 |
Effects of lidocaine patch on intradermal capsaicin-induced pain: a double-blind, controlled trial.
Topics: Anesthetics, Local; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Lidocaine; Pain; Pain Measurement; Pain Threshold; Time Factors; Transdermal Patch | 2011 |
Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Capsaicin; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fentanyl; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Pain; Pain Measurement; Time Factors; Transdermal Patch; Young Adult | 2011 |
Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain.
Topics: Administration, Cutaneous; Analgesics; Analgesics, Opioid; Buprenorphine; Capsaicin; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fentanyl; Humans; Hyperalgesia; Male; Nerve Growth Factor; Pain; Pain Measurement; Skin; Young Adult | 2011 |
Self-reported sleep duration associated with distraction analgesia, hyperemia, and secondary hyperalgesia in the heat-capsaicin nociceptive model.
Topics: Analgesia; Attention; Capsaicin; Humans; Hyperalgesia; Hyperemia; Pain Measurement; Pain Threshold; Self Report; Sleep; Video Games | 2011 |
Antihyperalgesic efficacy of 5% lidocaine medicated plaster in capsaicin and sunburn pain models--two randomized, double-blinded, placebo-controlled crossover trials in healthy volunteers.
Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Capsaicin; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Lidocaine; Neuralgia; Pain Measurement; Physical Stimulation; Sunburn; Treatment Outcome; Young Adult | 2011 |
Sensory responses to injection and punctate application of capsaicin and histamine to the skin.
Topics: Acute Pain; Capsaicin; Female; Histamine; Histamine Agonists; Humans; Hyperalgesia; Injections, Intradermal; Male; Nociceptors; Sensory System Agents; Skin | 2011 |
Biomarkers for visceral hypersensitivity identified by classification of electroencephalographic frequency alterations.
Topics: Acids; Adult; Biomarkers; Capsaicin; Colon, Sigmoid; Cross-Over Studies; Data Interpretation, Statistical; Electric Stimulation; Electroencephalography; Esophagus; Female; Humans; Hyperalgesia; Linear Models; Male; Middle Aged; Pain Perception; Pain Threshold; Regression Analysis; Reproducibility of Results; User-Computer Interface; Wavelet Analysis; Young Adult | 2011 |
Increased contact heat pain and shortened latencies of contact heat evoked potentials following capsaicin-induced heat hyperalgesia.
Topics: Adult; Capsaicin; Evoked Potentials, Somatosensory; Female; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Reaction Time; Sensory System Agents; Skin; Skin Temperature | 2012 |
The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica.
Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Minocycline; Pain; Pregabalin; Sciatica; Time Factors; Treatment Outcome | 2012 |
NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Isoquinolines; Male; Pain; Pain Measurement; Prodrugs; Receptors, AMPA; Receptors, Kainic Acid; Sensory System Agents; Tetrazoles; Young Adult | 2012 |
Amygdala activity contributes to the dissociative effect of cannabis on pain perception.
Topics: Adult; Amygdala; Analgesics, Non-Narcotic; Antigens, Viral; Capsaicin; Cross-Over Studies; Dissociative Disorders; Double-Blind Method; Dronabinol; Heart Rate; Humans; Hyperalgesia; Male; Pain Perception; Placebos; Psychomotor Performance; Sensory System Agents; Young Adult | 2013 |
Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia.
Topics: Adult; Analgesics; Benzimidazoles; Cannabinoid Receptor Agonists; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Psychotropic Drugs; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulfonamides; Treatment Outcome; Young Adult | 2013 |
Naloxone increases pain induced by topical capsaicin in healthy human volunteers.
Topics: Administration, Topical; Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Synergism; Female; Humans; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Pain; Psychophysics; Receptors, Opioid | 2002 |
Assessment of the reproducibility of intradermal administration of capsaicin as a model for inducing human pain.
Topics: Analysis of Variance; Arm; Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Reproducibility of Results | 2002 |
The effect of chronic oral desipramine on capsaicin-induced allodynia and hyperalgesia: a double-blinded, placebo-controlled, crossover study.
Topics: Adult; Antidepressive Agents, Tricyclic; Capsaicin; Cross-Over Studies; Desipramine; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Touch | 2002 |
Dose response of intrathecal adenosine in experimental pain and allodynia.
Topics: Adenosine; Administration, Topical; Adult; Aminophylline; Analgesics, Non-Narcotic; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Infusions, Intravenous; Injections, Spinal; Male; Middle Aged; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists | 2002 |
Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation.
Topics: Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Irritants; Male; Nociceptors; Pain; Prefrontal Cortex; Principal Component Analysis; Psychophysics; Regional Blood Flow; Regression Analysis; Skin; Tomography, Emission-Computed | 2003 |
Chili pepper and rectal hyperalgesia in irritable bowel syndrome.
Topics: Capsaicin; Capsicum; Colonic Diseases, Functional; Cross-Over Studies; Diet; Dilatation; Humans; Hyperalgesia; Pain Threshold; Rectal Diseases; Visceral Afferents | 2003 |
Gut pain and hyperalgesia induced by capsaicin: a human experimental model.
Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Ileostomy; Ileum; Intestinal Mucosa; Male; Middle Aged; Pain; Pain Measurement; Statistics, Nonparametric | 2003 |
Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia.
Topics: Adult; Analgesics, Opioid; Capsaicin; Female; Humans; Hyperalgesia; Male; Nausea; Oxyhemoglobins; Pain Measurement; Piperidines; Remifentanil | 2003 |
A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A.
Topics: Adult; Analgesics; Botulinum Toxins, Type A; Capsaicin; Double-Blind Method; Electric Stimulation; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Pain Threshold; Placebos; Reference Values; Skin; Treatment Outcome | 2003 |
A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
Topics: Adult; Analgesics, Opioid; Anticonvulsants; Capsaicin; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Hot Temperature; Humans; Hydromorphone; Hyperalgesia; Lamotrigine; Pain; Pain Measurement; Piperidines; Remifentanil; Triazines | 2003 |
The heat/capsaicin sensitization model: a methodologic study.
Topics: Adolescent; Adult; Capsaicin; Cross-Over Studies; Hot Temperature; Humans; Hyperalgesia; Male; Models, Neurological; Pain Measurement; Physical Stimulation; Reference Values; Reproducibility of Results; Skin; Time Factors | 2003 |
A human model of intraoral pain and heat hyperalgesia.
Topics: Administration, Topical; Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Facial Pain; Female; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Mouth Mucosa; Pain Measurement; Sensory Thresholds; Statistics, Nonparametric; Surveys and Questionnaires | 2003 |
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Injections, Subcutaneous; Ketamine; Lidocaine; Male; Pain; Skin | 2004 |
Effect of the new H1-antagonist ReN1869 on capsaicin-induced hyperalgesia in human skin/Human phase-I trial using somatosensory evoked potentials induced by a CO2 laser.
Topics: Adult; Arousal; Capsaicin; Cross-Over Studies; Double-Blind Method; Electroencephalography; Evoked Potentials, Somatosensory; Histamine H1 Antagonists; Humans; Hyperalgesia; Lasers; Male; Pain Measurement; Piperidines; Skin | 2004 |
[Differentiation of peripheral and central hyperalgesic effects of systemic procaine].
Topics: Anesthetics, Local; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Infusions, Parenteral; Injections, Subcutaneous; Nociceptors; Pain Measurement; Procaine; Time Factors | 2004 |
Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model.
Topics: Administration, Oral; Adult; Analysis of Variance; Capsaicin; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Lamotrigine; Male; Middle Aged; Pain Measurement; Pyrimidines; Sodium Channel Blockers; Sodium Channels; Triazines | 2004 |
Analgesic effects of low-dose intravenous orphenadrine in the state of capsaicin hyperalgesia. A randomised, placebo-controlled, double-blind cross-over study using laser somatosensory evoked potentials obtained from capsaicin-irritated skin in healthy vo
Topics: Adolescent; Adult; Analgesics; Antiparkinson Agents; Capsaicin; Double-Blind Method; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Injections, Intravenous; Irritants; Lasers; Male; Middle Aged; Orphenadrine; Pain Measurement; Peripheral Nervous System; Skin | 2004 |
Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia.
Topics: Adult; Amines; Analgesics; Capsaicin; Central Nervous System; Cyclohexanecarboxylic Acids; Double-Blind Method; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation | 2004 |
Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect.
Topics: Adolescent; Adult; Area Under Curve; Capsaicin; Cross-Over Studies; Dextromethorphan; Dextrorphan; Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Infusions, Intravenous; Male; Pain; Pain Measurement; Pain Threshold; Reaction Time; Time Factors; Treatment Outcome | 2005 |
Modulation of pain processing in hyperalgesia by cognitive demand.
Topics: Adult; Attention; Capsaicin; Cognition; Female; Hot Temperature; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Pain; Psychomotor Performance; Reaction Time | 2005 |
Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials fro
Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Diclofenac; Double-Blind Method; Drug Combinations; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Infusions, Intravenous; Lasers; Male; Middle Aged; Orphenadrine; Pain | 2005 |
The impact of ethnic differences in response to capsaicin-induced trigeminal sensitization.
Topics: Adult; Asian People; Capsaicin; Humans; Hyperalgesia; Male; Outcome Assessment, Health Care; Pain Measurement; Pain Threshold; Trigeminal Nerve; White People | 2005 |
Differential coding of hyperalgesia in the human brain: a functional MRI study.
Topics: Adult; Brain; Capsaicin; Cerebral Cortex; Echo-Planar Imaging; Female; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Pain Measurement; Physical Stimulation; Prefrontal Cortex; Psychophysics | 2005 |
Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.
Topics: Adult; Amines; Analgesics; Analysis of Variance; Capsaicin; Central Nervous System; Cross-Over Studies; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Pain; Psychophysics | 2005 |
Secondary heat hyperalgesia detected by radiant heat stimuli in humans: evaluation of stimulus intensity and duration.
Topics: Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Time Factors | 2005 |
Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia.
Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Dissociative; Area Under Curve; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain Measurement; Time Factors | 2006 |
Hyperalgesia against capsaicin in persons with un-investigated dyspepsia: potential as a new diagnostic test.
Topics: Adult; Capsaicin; Dyspepsia; Female; Humans; Hyperalgesia; Jejunum; Male; Pain Threshold; Reproducibility of Results; Sensitivity and Specificity | 2006 |
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Method; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glycine; Humans; Hyperalgesia; Indans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate | 2006 |
The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Ketorolac; Male; Pain; Pain Measurement; Pain Threshold; Placebos | 2006 |
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-Blind Method; Drug Administration Routes; Drug Administration Schedule; Female; Fentanyl; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain; Pain Measurement; Toothache | 2007 |
Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Capsaicin; Dextromethorphan; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Morphine; Pain; Thigh | 2007 |
Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capsaicin; Cholinergic Agents; Cross-Over Studies; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Hyperalgesia; Indomethacin; Iontophoresis; Male; Neurons, Afferent; Nociceptors; Norepinephrine; Pain; Prostaglandins; Sodium Chloride; Vasodilation | 2007 |
Reaction to topical capsaicin in spinal cord injury patients with and without central pain.
Topics: Administration, Topical; Adult; Aged; Analgesics, Non-Narcotic; Autonomic Nervous System; Capsaicin; Cold Temperature; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Physical Stimulation; Spinal Cord Injuries; Thoracic Vertebrae | 2007 |
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia.
Topics: Aminopyridines; Analgesics; Capsaicin; Cross-Over Studies; Cyclopentanes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Nervous System Diseases; Pain; Physical Stimulation; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2008 |
Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.
Topics: Adult; Analgesics, Non-Narcotic; Botulinum Toxins, Type A; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Middle Aged; Neurotoxins; Nociceptors; Pain; Pain Measurement; Pain Threshold; Placebos; Prospective Studies; Sensory Receptor Cells; Skin | 2007 |
Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.
Topics: Adult; Analgesics, Non-Narcotic; Cannabinoids; Cannabis; Capsaicin; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Female; Humans; Hyperalgesia; Male; Marijuana Smoking; Neuropsychological Tests; Pain; Pain Measurement; Reference Values; Sensory System Agents; Sensory Thresholds; Time Factors | 2007 |
A psychophysical study of secondary hyperalgesia: evidence for increased pain to input from nociceptors.
Topics: Adult; Animals; Capsaicin; Cold Temperature; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Male; Mechanoreceptors; Nociceptors; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Wool | 1994 |
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man.
Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Dermatitis; Double-Blind Method; Female; Freezing; Humans; Hyperalgesia; Ibuprofen; Male; Skin; Stress, Mechanical; Treatment Outcome | 1995 |
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intradermal; Ketamine; Male; Midazolam; Pain; Pain Threshold; Palliative Care; Placebos; Receptors, N-Methyl-D-Aspartate; Skin | 1995 |
Mechanisms of allodynia: interactions between sensitive mechanoreceptors and nociceptors.
Topics: Adult; Axons; Capsaicin; Female; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Mechanoreceptors; Middle Aged; Mustard Plant; Nociceptors; Physical Stimulation; Plant Extracts; Plant Oils; Regional Blood Flow; Skin; Skin Physiological Phenomena; Vasodilation | 1996 |
The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study.
Topics: Adult; Anesthetics, Dissociative; Capsaicin; Double-Blind Method; Electric Stimulation; Electrophysiology; H-Reflex; Hot Temperature; Humans; Hyperalgesia; Ketamine; Lasers; Nociceptors; Pain Measurement; Pain Threshold; Placebos; Psychophysics; Reaction Time | 1996 |
Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia.
Topics: Administration, Topical; Aspirin; Capsaicin; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Pain; Palliative Care; Sensation Disorders | 1996 |
Independent effects of ischaemia and noradrenaline on thermal hyperalgesia in capsaicin-treated skin.
Topics: Adult; Capsaicin; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Ischemia; Male; Norepinephrine; Pain Threshold; Skin | 1996 |
The sympathetic nervous system contributes to capsaicin-evoked mechanical allodynia but not pinprick hyperalgesia in humans.
Topics: Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Pain; Phentolamine; Placebos; Sympathetic Nervous System; Sympatholytics; Touch | 1996 |
Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin.
Topics: Analysis of Variance; Capsaicin; Hair; Hot Temperature; Humans; Hyperalgesia; Injections, Subcutaneous; Pain Threshold; Psychophysics; Skin; Stress, Mechanical | 1996 |
Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia.
Topics: Adolescent; Adult; Anesthetics, Local; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Infusion Pumps; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Pain Measurement; Pain Threshold; Placebos; Sensory Thresholds; Skin Temperature | 1997 |
Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans.
Topics: Adult; Alfentanil; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Capsaicin; Drug Interactions; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Reproducibility of Results | 1997 |
Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hyperalgesia; Ibuprofen; Male; Nociceptors; Pain Measurement; Pain Threshold; Skin Temperature | 1997 |
A model of transient hyperalgesia in the behaving monkey induced by topical application of capsaicin.
Topics: Acute Disease; Administration, Cutaneous; Adult; Analysis of Variance; Animals; Capsaicin; Conditioning, Operant; Escape Reaction; Hot Temperature; Humans; Hyperalgesia; Macaca mulatta; Male; Middle Aged; Photic Stimulation; Stress, Mechanical | 1997 |
Correlation between local vascular and sensory changes following tissue inflammation induced by repetitive application of topical capsaicin.
Topics: Administration, Topical; Adult; Capsaicin; Dermatitis, Contact; Humans; Hyperalgesia; Male; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Skin Temperature | 1998 |
Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Capsaicin; Cognition; Cross-Over Studies; Double-Blind Method; Drug Combinations; Excitatory Amino Acid Antagonists; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intradermal; Irritants; Ketamine; Male; Pain; Psychomotor Performance; Treatment Outcome | 1998 |
Capsaicin-induced impairment of tactile spatial discrimination ability in man: indirect evidence for increased receptive fields in human nervous system.
Topics: Adult; Capsaicin; Discrimination Learning; Humans; Hyperalgesia; Male; Pain; Sensory Thresholds; Somatosensory Cortex; Touch; Vibration | 1998 |
The human capsaicin model of allodynia and hyperalgesia: sources of variability and methods for reduction.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Pain Measurement | 1998 |
Intrathecal, but not intravenous, clonidine reduces experimental thermal or capsaicin-induced pain and hyperalgesia in normal volunteers.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Blood Pressure; Capsaicin; Clonidine; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Injections, Intravenous; Injections, Spinal; Male; Pain | 1998 |
AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans.
Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Isoquinolines; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Receptors, AMPA; Receptors, Kainic Acid; Skin; Tetrazoles | 1998 |
Flare and hyperalgesia after intradermal capsaicin injection in human skin.
Topics: Adult; Anesthetics, Local; Capsaicin; Color; Dermatitis, Irritant; Female; Heart; Humans; Hyperalgesia; Hyperemia; Injections, Intradermal; Male; Middle Aged; Pain Threshold; Physical Stimulation; Skin Temperature | 1998 |
Nitroprusside inhibits thermal hyperalgesia induced by noradrenaline in capsaicin-treated skin.
Topics: Adolescent; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Middle Aged; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Pain Threshold; Regional Blood Flow; Skin; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia.
Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesia; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Pain Threshold; Paresthesia; Premedication; Prilocaine; Reference Values; Severity of Illness Index; Single-Blind Method; Treatment Outcome | 1999 |
Sensory threshold changes without initial pain or alterations in cutaneous blood flow, in the area of secondary hyperalgesia caused by topical application of capsaicin in humans.
Topics: Administration, Topical; Adult; Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Nerve Fibers; Pain; Physical Stimulation; Regional Blood Flow; Sensory Thresholds; Skin; Vibration | 1999 |
A new human experimental pain model: the heat/capsaicin sensitization model.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Pain; Reference Values | 1999 |
The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction.
Topics: Adult; Analgesics; Analgesics, Opioid; Axons; Capsaicin; Erythema; Female; Fentanyl; Humans; Hyperalgesia; Injections, Intradermal; Ketamine; Male; Middle Aged; Nociceptors; Reflex | 1999 |
Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia.
Topics: Adult; Analgesics; Blood Pressure; Capsaicin; Clonidine; Dose-Response Relationship, Drug; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Male; Pain | 2000 |
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.
Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Paresthesia; Physical Stimulation; Pruritus; Skin; Skin Physiological Phenomena; Skin Tests; Time Factors | 1999 |
Secondary hyperalgesia persists in capsaicin desensitized skin.
Topics: Administration, Topical; Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Nociceptors; Pain Threshold; Physical Stimulation; Skin | 2000 |
Age-related differences in the time course of capsaicin-induced hyperalgesia.
Topics: Administration, Topical; Adult; Aged; Aging; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Time Factors | 2000 |
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action.
Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Intravenous; Laser-Doppler Flowmetry; Lidocaine; Male; Middle Aged; Pain Measurement | 2000 |
Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans.
Topics: Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Ketamine; Lidocaine; Male; Pain Measurement; Pain Threshold; Touch | 2000 |
Spatial mapping of the zone of secondary hyperalgesia reveals a gradual decline of pain with distance but sharp borders.
Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Injections, Subcutaneous; Male; Middle Aged; Pain Measurement; Physical Stimulation; Reference Values | 2000 |
The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers.
Topics: Adult; Anesthetics, Local; Capsaicin; Cross-Over Studies; Dizziness; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Male; Nociceptors; Pain; Pain Measurement; Pain Threshold; Placebos; Skin; Sleep Stages; Vision Disorders; Xerostomia | 2000 |
Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans.
Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Lidocaine; Male; Pain Measurement; Touch | 2000 |
Effect of remifentanil on pain and secondary hyperalgesia associated with the heat--capsaicin sensitization model in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Piperidines; Remifentanil | 2001 |
The effect of sympathetic activity on thermal hyperalgesia in capsaicin-treated skin during body cooling and warming.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Capsaicin; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Phenoxybenzamine; Receptors, Adrenergic, alpha; Skin; Sympathetic Nervous System | 2001 |
Differential time courses of skin blood flow and hyperalgesia in the human sunburn reaction following ultraviolet irradiation of the skin.
Topics: Adult; Capsaicin; Dose-Response Relationship, Radiation; Erythema; Female; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Middle Aged; Pain Threshold; Regional Blood Flow; Skin; Sunburn; Ultraviolet Rays | 2001 |
Repeated local administration of noradrenaline or saline inhibits thermal hyperalgesia in pain-sensitized human skin.
Topics: Administration, Cutaneous; Adolescent; Adult; Capsaicin; Female; Humans; Hyperalgesia; Male; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Regional Blood Flow; Skin; Sodium Chloride; Vasoconstrictor Agents | 2001 |
Characterization of secondary hyperalgesia produced by topical capsaicin jelly--a new experimental tool for pain research.
Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Female; Gels; Humans; Hyperalgesia; Male; Nociceptors; Pain; Reproducibility of Results | 2001 |
Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
Topics: Adenosine; Adult; Analgesics; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Spinal; Male; Middle Aged; Pain; Pain Threshold | 2002 |
The effect of heat conditioning of the primary area before and after induction of hyperalgesia by topical/intradermal capsaicin or by controlled heat injury.
Topics: Administration, Topical; Adult; Burns; Capsaicin; Conditioning, Psychological; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Skin Temperature | 2001 |
Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Middle Aged; Pain Threshold; Touch | 2002 |
570 other study(ies) available for capsaicin and Allodynia
| Article | Year |
|---|---|
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetulus; Drug Discovery; Hyperalgesia; Mice, Inbred ICR; Neuralgia; Phenylurea Compounds; Swine; Thiazoles; TRPV Cation Channels | 2020 |
Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
Topics: Analgesics; Animals; Anoctamin-1; Carboxylic Acids; HEK293 Cells; Humans; Hyperalgesia; Mice; Neoplasm Proteins; Pain | 2022 |
Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans.
Topics: Adult; Capsaicin; Central Nervous System Sensitization; Double-Blind Method; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Sensory System Agents; Young Adult | 2021 |
Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred ICR; Pain; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; TRPV Cation Channels | 2021 |
How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex.
Topics: Adult; Capsaicin; Central Nervous System Sensitization; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Models, Theoretical; Nociception; Pain Threshold; Physical Stimulation; Reflex; Sensory System Agents; Sural Nerve | 2021 |
Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain.
Topics: Animals; Capsaicin; Chronic Pain; Hyperalgesia; Mice; Microtubules; Neuralgia; Paclitaxel; Trigeminal Neuralgia; TRPV Cation Channels; Tubulin | 2022 |
The industrial solvent 1,4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1.
Topics: Animals; Capsaicin; Dioxanes; Hyperalgesia; Mice; Solvents; TRPV Cation Channels | 2022 |
Priming of central and peripheral mechanisms with heat and cutaneous capsaicin facilitates secondary hyperalgesia to high-frequency electrical stimulation.
Topics: Capsaicin; Electric Stimulation; Hot Temperature; Humans; Hyperalgesia; Pain; Pain Threshold | 2022 |
Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 activation, and CGRP release.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Docosahexaenoic Acids; Hyperalgesia; Lipopolysaccharides; Mice; Monocytes; Neurons; Neutrophils; Nociceptors; Pain; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2022 |
Age-related changes in peripheral nociceptor function.
Topics: Aged; Analgesics, Opioid; Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Hyperalgesia; Nociceptors; Pain; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensory Receptor Cells | 2022 |
Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1.
Topics: Animals; Calcium; Capsaicin; Chronic Pain; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Mice; Phosphorylation; Protein Kinase C; src-Family Kinases; TRPV Cation Channels | 2022 |
Cell type-specific calcium imaging of central sensitization in mouse dorsal horn.
Topics: Animals; Calcium; Capsaicin; Central Nervous System Sensitization; Hyperalgesia; Mice; Posterior Horn Cells; Spinal Cord Dorsal Horn | 2022 |
Small Synthetic Hyaluronan Disaccharide BIS014 Mitigates Neuropathic Pain in Mice.
Topics: Animals; Capsaicin; Gabapentin; Hyaluronic Acid; Hyperalgesia; Mice; Neuralgia; TRPV Cation Channels | 2023 |
Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia.
Topics: Arousal; Capsaicin; Humans; Hyperalgesia; Pain; Pain Measurement; Skin | 2022 |
Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain.
Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Diosgenin; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Mice; Neuralgia; TRPV Cation Channels | 2022 |
Machine learning analysis predicts a person's sex based on mechanical but not thermal pain thresholds.
Topics: Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Machine Learning; Male; Pain; Pain Measurement; Pain Threshold | 2023 |
Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats.
Topics: Animals; Capsaicin; Chronic Pain; Dry Eye Syndromes; Eye Pain; Female; Hyperalgesia; Neuralgia; Rats; Rats, Sprague-Dawley; Tears | 2023 |
Effects of conditioned pain modulation on Capsaicin-induced spreading muscle hyperalgesia in humans.
Topics: Capsaicin; Humans; Hyperalgesia; Male; Myalgia; Pain Measurement; Rotator Cuff | 2023 |
Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Chronic Pain; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Inflammation; Methoxsalen; Mice | 2023 |
Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons.
Topics: Animals; Calbindin 2; Capsaicin; Hyperalgesia; Interneurons; Male; Memory; Mice, Inbred C57BL; Neural Pathways; Nociception; Optogenetics; Parabrachial Nucleus; Posterior Horn Cells; Recruitment, Neurophysiological; Spinal Cord Dorsal Horn | 2019 |
Age and Sex Differences in Acute and Osteoarthritis-Like Pain Responses in Rats.
Topics: Aging; Animals; Arthritis, Experimental; Behavior, Animal; Capsaicin; Enzyme Inhibitors; Female; Hyperalgesia; Iodoacetic Acid; Male; Pain Measurement; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats, Inbred F344; Sex Factors; Spinal Cord; Weight-Bearing | 2020 |
The opposing contribution of neurotrophin-3 and nerve growth factor to orofacial heat hyperalgesia in rats.
Topics: Animals; Capsaicin; Facial Pain; Hot Temperature; Hyperalgesia; Male; Nerve Growth Factor; Neurotrophin 3; Rats; Rats, Wistar; Receptor, trkA; Trigeminal Neuralgia | 2020 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Nociception; Nucleus Accumbens; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Stress, Psychological | 2020 |
Abnormal Pain Sensation in Mice Lacking the Prokineticin Receptor PKR2: Interaction of PKR2 with Transient Receptor Potential TRPV1 and TRPA1.
Topics: Amphibian Proteins; Animals; Capsaicin; Ganglia, Spinal; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Neuropeptides; Nociception; Pain; Plant Oils; Receptors, G-Protein-Coupled; TRPA1 Cation Channel; TRPV Cation Channels | 2020 |
Experimenter- and Infrared Thermography-Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults.
Topics: Adult; Black or African American; Capsaicin; Ethnicity; Humans; Hyperalgesia; Minority Groups; Thermography | 2020 |
Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice.
Topics: Animals; Calcineurin Inhibitors; Capsaicin; Colon; Hyperalgesia; Immunosuppressive Agents; Irritable Bowel Syndrome; Mice; Tacrolimus; TRPV Cation Channels | 2020 |
Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats.
Topics: Animals; Capsaicin; Denervation; Humans; Hyperalgesia; Microscopy, Confocal; Pain, Postoperative; Rats | 2020 |
Thiopental Does Not Produce Hyperalgesia: A Laboratory Study Using Two Human Experimental Pain Models.
Topics: Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Laboratories; Pain; Thiopental | 2020 |
Capsaicin-Induced Changes in Electrical Pain Perception Threshold Can Be Used to Assess the Magnitude of Secondary Hyperalgesia in Humans.
Topics: Capsaicin; Hot Temperature; Humans; Hyperalgesia; Pain; Pain Perception; Pain Threshold | 2020 |
Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats.
Topics: Analgesics; Animals; Calcium Channels, N-Type; Capsaicin; Disease Models, Animal; Facial Pain; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Neuralgia; omega-Conotoxins; Pain Measurement; Rats; Rats, Wistar; TRPA1 Cation Channel | 2020 |
The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin.
Topics: Animals; Bradykinin; Capsaicin; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Nociception; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sensory System Agents; TRPV Cation Channels | 2020 |
Modality-specific facilitation of noninjurious sharp mechanical pain by topical capsaicin.
Topics: Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold | 2021 |
Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anesthesia, Local; Anesthetics, Local; Animals; Calorimetry, Differential Scanning; Capsaicin; Carrageenan; Disease Models, Animal; Drug Compounding; Drug Stability; Drug Therapy, Combination; Excipients; Hyperalgesia; Inflammation; Magnetic Resonance Spectroscopy; Male; Mepivacaine; Mice; Microscopy, Electron, Scanning; Pain; Pain Management; Solubility; X-Ray Diffraction | 2020 |
Pain-autonomic interaction: A surrogate marker of central sensitization.
Topics: Biomarkers; Capsaicin; Central Nervous System Sensitization; Humans; Hyperalgesia; Pain; Pain Measurement | 2020 |
Antiallodynic effect of PhAR-DBH-Me involves cannabinoid and TRPV1 receptors.
Topics: Animals; Antineoplastic Agents; Arachidonic Acids; Azabicyclo Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Cisplatin; Endocannabinoids; Female; Hyperalgesia; Injections, Intraperitoneal; Ligation; Models, Animal; Neuralgia; Oleic Acids; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spinal Nerves; TRPV Cation Channels; Vagus Nerve Stimulation | 2020 |
Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capsaicin; Castor Oil; Colitis, Ulcerative; Colon; Diarrhea; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Hyperalgesia; Inflammation; Lamiaceae; Male; Mice; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Visceral Pain | 2021 |
CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache.
Topics: Animals; Antibodies, Monoclonal; Brain Concussion; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Pain; Diffuse Noxious Inhibitory Control; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Post-Traumatic Headache | 2021 |
Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy.
Topics: Animals; Astrocytes; Capsaicin; Diterpenes; Ganglia, Spinal; Hyperalgesia; Intercellular Signaling Peptides and Proteins; Male; Neuralgia; Neurons; Rats, Sprague-Dawley; Spinal Cord | 2021 |
Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models.
Topics: Animals; Biomarkers; Capsaicin; Carrageenan; Endocannabinoids; Flurbiprofen; Gene Expression Regulation; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Pain | 2021 |
Sex-dependent Cav2.3 channel contribution to the secondary hyperalgesia in a mice model of central sensitization.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, R-Type; Capsaicin; Cation Transport Proteins; Central Nervous System Sensitization; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Gene Knockdown Techniques; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Oligonucleotides, Antisense; Sex Characteristics; Spider Venoms; Spinal Cord | 2021 |
Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model.
Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Spinal Cord; TRPV Cation Channels | 2021 |
During capsaicin-induced central sensitization, brush allodynia is associated with baseline warmth sensitivity, whereas mechanical hyperalgesia is associated with painful mechanical sensibility, anxiety and somatization.
Topics: Anxiety; Capsaicin; Central Nervous System Sensitization; Humans; Hyperalgesia; Male; Neuralgia; Pain Threshold; Reproducibility of Results | 2021 |
Postinjury stimulation triggers a transition to nociplastic pain in mice.
Topics: Animals; Capsaicin; Chronic Pain; Female; Humans; Hyperalgesia; Male; Mice; Morphine; Pain Measurement | 2022 |
A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain.
Topics: Animals; Botulinum Toxins; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Male; Models, Molecular; Motor Activity; Neuralgia; Peptide Hydrolases; Pregabalin; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Sensory Receptor Cells; Synaptosomal-Associated Protein 25; Time Factors; Trigeminal Ganglion | 2017 |
Differential effect of Incobotulinumtoxin A on pain, neurogenic flare and hyperalgesia in human surrogate models of neurogenic pain.
Topics: Adult; Botulinum Toxins, Type A; Capsaicin; Electric Stimulation; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Nerve Fibers, Unmyelinated; Neuralgia; Neuromuscular Agents; Pain Measurement; Pain Threshold; Sensory System Agents; Young Adult | 2017 |
Chronic stress-induced mechanical hyperalgesia is controlled by capsaicin-sensitive neurones in the mouse.
Topics: Animals; Capsaicin; Cold Temperature; Disease Models, Animal; Diterpenes; Hot Temperature; Hyperalgesia; Male; Mice; Nociception; Nociceptive Pain; Nociceptors; Restraint, Physical; Stress, Psychological | 2017 |
Role of peripheral and central TRPV1 receptors in facial heat hyperalgesia in streptozotocin-induced diabetic rats.
Topics: Animals; Capsaicin; Diabetes Mellitus, Experimental; Diterpenes; Face; Facial Pain; Hot Temperature; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Trigeminal Ganglion; TRPV Cation Channels | 2017 |
Effects of Tetrodotoxin in Mouse Models of Visceral Pain.
Topics: Analgesics; Animals; Capsaicin; Colon; Cystitis; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Knockout; Morphine; Mustard Plant; Nociceptors; Pain Measurement; Plant Oils; Sodium Channels; Tetrodotoxin; Visceral Pain | 2017 |
D-limonene exhibits superior antihyperalgesic effects in a β-cyclodextrin-complexed form in chronic musculoskeletal pain reducing Fos protein expression on spinal cord in mice.
Topics: Analgesics; Animals; beta-Cyclodextrins; Capsaicin; Cyclohexenes; Disease Models, Animal; Drug Combinations; Drug Interactions; GABA Agents; Hyperalgesia; Limonene; Male; Mice; Muscle Strength; Musculoskeletal Pain; Nociception; Pain Measurement; Pain Threshold; Proto-Oncogene Proteins c-fos; Spinal Cord; Statistics, Nonparametric; Terpenes | 2017 |
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis.
Topics: Adult; Capsaicin; Female; Healthy Volunteers; Humans; Hyperalgesia; Machine Learning; Male; Pain Measurement; Pain Threshold; Skin; Ultraviolet Rays; Young Adult | 2018 |
Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla.
Topics: Animals; Capsaicin; Catheters, Indwelling; Central Nervous System Sensitization; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Microelectrodes; Neurokinin-1 Receptor Antagonists; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Touch | 2017 |
Low-threshold mechanoreceptors play a frequency-dependent dual role in subjective ratings of mechanical allodynia.
Topics: Adult; Brain; Brain Mapping; Capsaicin; Female; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Mechanoreceptors; Neurons, Afferent; Pain Perception; Physical Stimulation | 2017 |
Characterization of a novel capsaicin/heat ongoing pain model.
Topics: Adolescent; Adult; Capsaicin; Female; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Sensation; Skin; Young Adult | 2018 |
Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross-Sectional Study.
Topics: Adolescent; Capsaicin; Cross-Sectional Studies; Female; Humans; Hyperalgesia; Male; Migraine Disorders; Oxytocin; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Sensory System Agents; Statistics, Nonparametric; Surveys and Questionnaires; Time Factors; Young Adult | 2018 |
Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Disease Models, Animal; Hyperalgesia; Ketorolac; Male; Piroxicam; Rats; Rats, Wistar; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
Cerebral peak alpha frequency predicts individual differences in pain sensitivity.
Topics: Adult; Alpha Rhythm; Biomarkers; Capsaicin; Central Nervous System Sensitization; Electroencephalography; Female; Humans; Hyperalgesia; Individuality; Male; Pain Measurement; Pain Perception; Pain Threshold; Sensorimotor Cortex; Sensory System Agents; Young Adult | 2018 |
Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents.
Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Drug Resistance; Facial Nerve Diseases; Hindlimb; Hot Temperature; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Migraine Disorders; Nerve Tissue Proteins; Neurons, Afferent; Neurotoxins; Nitric Oxide Donors; Nitroglycerin; Organ Specificity; Peripheral Nervous System Diseases; Sensory System Agents; TRPV Cation Channels | 2018 |
A novel human pain insensitivity disorder caused by a point mutation in ZFHX2.
Topics: Action Potentials; Adolescent; Adult; Aged; Animals; Calcium; Capsaicin; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Pain; Pain Insensitivity, Congenital; Pain Threshold; Point Mutation; Sensory Receptor Cells; Skin; Young Adult; Zinc Finger E-box Binding Homeobox 2 | 2018 |
Physiological and pathological characterization of capsaicin-induced reversible nerve degeneration and hyperalgesia.
Topics: Adult; Capsaicin; Evoked Potentials; Female; Humans; Hyperalgesia; Male; Nerve Degeneration; Nerve Fibers; Pain Threshold; Skin; Young Adult | 2018 |
Supraspinal modulation of neuronal synchronization by nociceptive stimulation induces an enduring reorganization of dorsal horn neuronal connectivity.
Topics: Anesthetics, Local; Animals; Capsaicin; Cats; Female; Hyperalgesia; Lidocaine; Male; Nerve Net; Nociception; Physical Stimulation; Posterior Horn Cells; Sensory System Agents | 2018 |
Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models.
Topics: Adult; Aged; Algorithms; Capsaicin; Female; Healthy Volunteers; Humans; Hyperalgesia; Lidocaine; Male; Middle Aged; Models, Biological; Nerve Block; Neuralgia; Pain Measurement; Pain Perception; Pain Threshold; Phenotype; Sensation; Sensory System Agents; Young Adult | 2018 |
Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Ethylnitrosourea; Ganglia, Spinal; Hyperalgesia; Ligation; Loss of Function Mutation; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Neurons; Phenotype; Potassium; Spinal Nerves; TRPV Cation Channels | 2018 |
Antinociception by the anti-oxidized phospholipid antibody E06.
Topics: Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Autoantibodies; Capsaicin; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Irritants; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidation-Reduction; Pain; Phosphatidylcholines; Rats, Wistar; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain.
Topics: Animals; Capsaicin; Chemokine CCL2; Chronic Pain; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pelvic Pain; Receptors, CCR2; Signal Transduction; Toll-Like Receptor 4; TRPV Cation Channels; Urinary Tract Infections; Uropathogenic Escherichia coli | 2018 |
Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors.
Topics: Acrylamides; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Binding Proteins; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fish Venoms; Ganglia, Spinal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Hyperalgesia; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurogenic Inflammation; Oncogene Proteins v-fos; Pain; Pain Measurement; Sensory Receptor Cells; Time Factors; Touch; TRPV Cation Channels | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia.
Topics: Acetylcysteine; Action Potentials; Animals; Biotinylation; Capsaicin; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Erythromycin; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Neurons; Patch-Clamp Techniques; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X4; Signal Transduction; TRPV Cation Channels | 2018 |
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; Ganglia, Spinal; Hyperalgesia; Lysergic Acid Diethylamide; Male; Maze Learning; Neuralgia; Piperazines; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Swimming | 2019 |
Pain chronification and chronic pain impair a defensive behavior, but not the ability of acute pain to facilitate it, through the activation of an endogenous analgesia circuit.
Topics: Acute Pain; Animals; Capsaicin; Chronic Pain; Freezing Reaction, Cataleptic; Hydroxy Acids; Hyperalgesia; Male; Neural Pathways; Nociceptive Pain; Nucleus Accumbens; Oleic Acids; Pain Perception; Random Allocation; Rats, Wistar; Receptors, Opioid, mu | 2018 |
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Topics: Action Potentials; Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Ion Channels; Mechanotransduction, Cellular; Mice, Knockout; Neurons; Nociception; Nociceptors; Pain | 2018 |
Vti1b promotes TRPV1 sensitization during inflammatory pain.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Humans; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pain; Qb-SNARE Proteins; RNA Interference; Sensory Receptor Cells; Signal Transduction; TRPV Cation Channels | 2019 |
Sex differences in measures of central sensitization and pain sensitivity to experimental sleep disruption: implications for sex differences in chronic pain.
Topics: Adult; Antipruritics; Attention; Capsaicin; Central Nervous System Sensitization; Chronic Pain; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Polysomnography; Sex Characteristics; Sleep; Sleep Deprivation | 2019 |
Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse.
Topics: Animals; Ankle Joint; Antibodies; Arthritis, Experimental; Body Weight; Capsaicin; Disease Models, Animal; Diterpenes; Edema; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Severity of Illness Index; X-Ray Microtomography | 2018 |
Dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Benzalkonium Compounds; Capsaicin; Cornea; Corneal Injuries; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Propionates; Sensory System Agents; Trigeminal Ganglion | 2019 |
Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy.
Topics: Animals; Capsaicin; Excitatory Postsynaptic Potentials; Hyperalgesia; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oncogene Protein v-akt; Paclitaxel; Peptide Fragments; Phosphatidylinositol 3-Kinases; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Spinal Cord; Toll-Like Receptor 4; Transient Receptor Potential Channels; TRPV Cation Channels | 2019 |
Capsaicin-induced pain and sensitisation in the postpartum period.
Topics: Adolescent; Adult; Animals; Capsaicin; Case-Control Studies; Cesarean Section; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Postoperative Period; Postpartum Period; Pregnancy; Rats, Sprague-Dawley; Stress, Psychological; Young Adult | 2019 |
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cystathionine beta-Synthase; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hydrogen Sulfide; Hydroxylamine; Hyperalgesia; Imidazoles; Nociception; Purines; Rats, Wistar; Skin; Spinal Nerve Roots; Sulfites; Transient Receptor Potential Channels | 2019 |
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Lidocaine; Male; Pain; Rats, Wistar | 2019 |
Differential activation of ascending noxious pathways associated with trigeminal nerve injury.
Topics: Animals; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Facial Pain; Hyperalgesia; Male; Nociceptors; Parabrachial Nucleus; Rats, Sprague-Dawley; Spinal Cord; Trigeminal Nerve Injuries | 2019 |
Transcription factor Sp4 is required for hyperalgesic state persistence.
Topics: Animals; Calcium; Capsaicin; Cold Temperature; Down-Regulation; Ganglia, Spinal; Heterozygote; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Growth Factor; Nociceptors; Oxaliplatin; Sp4 Transcription Factor; Stress, Mechanical; TRPV Cation Channels | 2019 |
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.
Topics: Acid Sensing Ion Channels; Animals; Capsaicin; Diabetes Mellitus, Experimental; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Mirtazapine; Rats; Streptozocin; TRPV Cation Channels | 2019 |
Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study.
Topics: Adult; Aged; Aged, 80 and over; Antipruritics; Capsaicin; Case-Control Studies; Chronic Disease; Female; Histamine; Histamine Agonists; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Peripheral Nerves; Physical Stimulation; Pruritus; Reaction Time; Skin; TRPV Cation Channels | 2019 |
Cutaneous nociceptive sensitization affects the directional discrimination - but not the 2-point discrimination.
Topics: Administration, Cutaneous; Adult; Antipruritics; Capsaicin; Discrimination, Psychological; Female; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Touch | 2019 |
Antinociceptive activity of Copaifera officinalis Jacq. L oil and kaurenoic acid in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Diterpenes; Fabaceae; Female; Freund's Adjuvant; Hyperalgesia; Male; Mice; Nociception; Oils, Volatile; Pain Measurement; Plant Extracts | 2019 |
Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain.
Topics: Animals; Capsaicin; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Irritants; Mentha piperita; Models, Animal; Mustard Plant; Myalgia; Neurons, Afferent; Nociceptive Pain; Nociceptors; Physical Stimulation; Plant Oils; Rats; Rats, Sprague-Dawley; Skin | 2020 |
The Acute Effect of Skin Preheating on Capsaicin-Induced Central Sensitization in Humans.
Topics: Adult; Capsaicin; Central Nervous System Sensitization; Cross-Over Studies; Female; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Male; Pain Measurement; Skin; Young Adult | 2019 |
Trigeminal Pain Responses in Obese ob/ob Mice Are Modality-Specific.
Topics: Animals; Behavior; Capsaicin; Diet; Eating; Hyperalgesia; Leptin; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Models, Animal; Nociception; Obesity; Pain; Pain Measurement; Quinine; Trigeminal Ganglion; TRPV Cation Channels | 2019 |
Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Calcium Channel Blockers; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Interneurons; Lidocaine; Male; Microscopy, Confocal; Neuropeptide Y; Nociception; omega-Conotoxins; Peripheral Nerve Injuries; Posterior Horn Cells; Potassium Chloride; Protein Transport; Protein Tyrosine Phosphatases; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide Y; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; TRPV Cation Channels; Voltage-Gated Sodium Channel Blockers | 2019 |
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular Structure; Olea; Pain; Pain Measurement; Pregabalin; Rotarod Performance Test; Time Factors; Triterpenes | 2013 |
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarates; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Rats; Rats, Sprague-Dawley | 2013 |
Capsaicin avoidance as a measure of chemical hyperalgesia in orofacial nerve injury models.
Topics: Animals; Avoidance Learning; Capsaicin; Constriction, Pathologic; Facial Pain; Hot Temperature; Hyperalgesia; Ligation; Lingual Nerve Injuries; Male; Neurons; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Touch; Trigeminal Nerve Injuries; Trigeminal Nuclei | 2013 |
Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms.
Topics: Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Edema; Hindlimb; Hyperalgesia; Inflammation; Male; Naloxone; Nociception; Oxidopamine; Pain; Rats; Rats, Sprague-Dawley; Restraint, Physical; Sciatic Nerve; Stress, Psychological; Sympathetic Nervous System | 2013 |
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histamine; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofibromatosis 1; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Pain Threshold; Pruritus | 2013 |
Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons.
Topics: Adenosine Triphosphate; Animals; Burns; Capsaicin; Cells, Cultured; Dermatitis; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neurons; Pain; Pinus; Plant Oils; Resins, Plant; Skin | 2014 |
Healthy volunteers can be phenotyped using cutaneous sensitization pain models.
Topics: Antipruritics; Burns; Capsaicin; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Models, Biological; Pain; Pain Measurement; Reproducibility of Results; Skin | 2013 |
Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.
Topics: A Kinase Anchor Proteins; Animals; Bacterial Proteins; Binding Sites; Calcium; Capsaicin; Carrageenan; Cell Line, Transformed; Chlorocebus aethiops; Female; Ganglia, Spinal; Humans; Hyperalgesia; Immunoprecipitation; Luminescent Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mutation; Neurons; Pain Threshold; Patch-Clamp Techniques; Peptides; Transfection; TRPV Cation Channels | 2013 |
Peripheral G protein-coupled inwardly rectifying potassium channels are involved in δ-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Brain Stem; Capsaicin; Enkephalin, D-Penicillamine (2,5)-; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genes, fos; Hyperalgesia; Immunohistochemistry; Male; Masseter Muscle; Physical Stimulation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Opioid, delta; RNA, Messenger; Sensory System Agents; Trigeminal Ganglion | 2014 |
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Benzoquinones; Capsaicin; Carrageenan; Cytokines; Disease Models, Animal; Freund's Adjuvant; Glycosides; Hyperalgesia; Inflammation; Male; Mice; Molecular Structure; Oxidative Stress; Pain; Plant Extracts; TRPV Cation Channels | 2013 |
Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Conditioning, Operant; Facial Nerve; Facial Pain; Hyperalgesia; Male; Menthol; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Trigeminal Nerve; Trigeminal Nerve Injuries; TRPM Cation Channels | 2013 |
Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Capsaicin; Catalase; Deoxyguanosine; Fluorescent Dyes; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hyperalgesia; Immunohistochemistry; Mice; Mice, Transgenic; Neurons; Oxidative Stress; Promoter Regions, Genetic; Satellite Cells, Perineuronal; SOXE Transcription Factors; Thioredoxins; Trigeminal Ganglion; TRPV Cation Channels | 2013 |
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Catheterization; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Synaptic Transmission | 2013 |
Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels.
Topics: Acetone; Acrolein; Acrylamides; Acute Disease; Alkaloids; Analgesics; Animals; Aporphines; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Chronic Pain; Cold Temperature; Freund's Adjuvant; Gene Expression; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2013 |
Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.
Topics: Action Potentials; Animals; Calcium; Capsaicin; Cells, Cultured; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Isothiocyanates; Mice; Mice, Inbred C57BL; Sensory Receptor Cells; Thermosensing; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2014 |
Facilitation of pain in the human spinal cord by nocebo treatment.
Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Oxygen; Pain; Pain Measurement; Pain Perception; Pain Threshold; Spinal Cord; Surveys and Questionnaires; Time Factors; Young Adult | 2013 |
Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice.
Topics: Acrolein; Analgesics; Animals; Asteraceae; Capsaicin; Ethanol; Flowers; Formaldehyde; Hot Temperature; Hyperalgesia; Ligation; Male; Mice; Pain; Phytotherapy; Plant Extracts; Sciatic Nerve; Solvents; Touch | 2013 |
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Polymers; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Time Factors | 2014 |
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Hyperalgesia; Hypersensitivity, Delayed; Lidocaine; Male; Nerve Block; Nerve Fibers; Neural Conduction; Neurotoxicity Syndromes; Nociceptors; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels | 2014 |
Polypeptide modulators of TRPV1 produce analgesia without hyperthermia.
Topics: Analgesia; Analgesics; Animals; Body Temperature; Capsaicin; Cell Line; Disease Models, Animal; Fever; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Male; Mice; Pain; Peptides; TRPV Cation Channels | 2013 |
Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain.
Topics: Acute Pain; Analysis of Variance; Animals; Capsaicin; Cerebral Cortex; Chronic Pain; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Hyperalgesia; Male; Neural Pathways; Rats; Rats, Sprague-Dawley; Thalamus; Theta Rhythm; Time Factors | 2014 |
TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia.
Topics: Anilides; Animals; Animals, Newborn; Capsaicin; Chemokine CCL2; Cinnamates; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Hyperalgesia; In Vitro Techniques; Male; MAP Kinase Kinase Kinase 3; Pain Threshold; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Wistar; Sensory System Agents; Spinal Cord; Time Factors; TRPV Cation Channels | 2014 |
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
Topics: Action Potentials; Animals; Capsaicin; Disease Models, Animal; Electrophysiology; Hindlimb; Histamine; Hyperalgesia; Injections, Intradermal; Mice; Mice, Inbred C57BL; Pain; Posterior Horn Cells; Pruritus; Sensory System Agents; Spinal Cord | 2014 |
Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia.
Topics: Animals; Capsaicin; Carrageenan; Cold Temperature; Disease Models, Animal; Diterpenes; Facial Pain; Formaldehyde; Hot Temperature; Hyperalgesia; Male; Neuralgia; Neurons; Nociception; Rats; Rats, Wistar; Sensory System Agents; Trigeminal Ganglion; TRPV Cation Channels | 2014 |
Complex generalized instead of complex regional?
Topics: Capsaicin; Complex Regional Pain Syndromes; Female; Hot Temperature; Humans; Hyperalgesia; Male | 2014 |
Endothelin-1-induced priming to capsaicin in young animals.
Topics: Animals; Animals, Newborn; Capsaicin; Endothelin-1; Female; Functional Laterality; Hyperalgesia; Male; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Sex Factors; Touch | 2014 |
Intradermal glutamate and capsaicin injections: intra- and interindividual variability of provoked hyperalgesia and allodynia.
Topics: Adolescent; Adult; Capsaicin; Glutamic Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation; Reproducibility of Results; Sensory System Agents; Touch; Young Adult | 2014 |
Evidence for acute central sensitization to prolonged experimental pain in posttraumatic stress disorder.
Topics: Acute Pain; Adult; Anxiety; Capsaicin; Catastrophization; Central Nervous System Sensitization; Chronic Pain; Comorbidity; Depression; Evidence-Based Medicine; Humans; Hyperalgesia; Male; Pain Threshold; Pressure; Quality of Life; Sensory System Agents; Stress Disorders, Post-Traumatic; Surveys and Questionnaires; Young Adult | 2014 |
Capsaicin-induced neurogenic inflammation in pig skin: a behavioural study.
Topics: Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Male; Neurogenic Inflammation; Random Allocation; Skin; Statistics, Nonparametric; Swine; Video Recording | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain.
Topics: Acid Sensing Ion Channels; Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Pain Measurement; Signal Transduction; Substance P; TRPV Cation Channels | 2014 |
LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain.
Topics: Administration, Oral; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Enzyme Activation; Female; Hydrogen-Ion Concentration; Hyperalgesia; Imidazoles; Inflammation; Macrophages, Peritoneal; MAP Kinase Signaling System; Mice, Inbred BALB C; Neuralgia; Neutrophil Infiltration; Oocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Time Factors; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Xenopus laevis | 2014 |
A spinal analog of memory reconsolidation enables reversal of hyperalgesia.
Topics: Animals; Anisomycin; Capsaicin; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Male; Memory; Mice; Mice, Inbred C57BL; Pain; Posterior Horn Cells; Protein Synthesis Inhibitors; Sensory System Agents; Spinal Cord | 2014 |
Spatio-temporal expression and functional involvement of transient receptor potential vanilloid 1 in diabetic mechanical allodynia in rats.
Topics: Analysis of Variance; Animals; Blotting, Western; Capsaicin; Diabetic Neuropathies; Fluorescent Antibody Technique; Ganglia, Spinal; Gene Expression Profiling; Gene Expression Regulation; Hyperalgesia; Image Processing, Computer-Assisted; Immunohistochemistry; Rats; Real-Time Polymerase Chain Reaction; Ruthenium Red; Spinal Cord; Streptozocin; Time Factors; TRPV Cation Channels | 2014 |
β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons.
Topics: Animals; Arrestins; Benzamides; beta-Arrestin 2; beta-Arrestins; Capsaicin; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Lectins; Male; Mice; Mice, Inbred C57BL; Pain Threshold; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sensory Receptor Cells; Sensory System Agents; Species Specificity; Time Factors; Trigeminal Ganglion; TRPV Cation Channels | 2014 |
Activation of transient receptor potential vanilloid 2-expressing primary afferents stimulates synaptic transmission in the deep dorsal horn of the rat spinal cord and elicits mechanical hyperalgesia.
Topics: Afferent Pathways; Animals; Capsaicin; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Male; Neurons; Nociception; Probenecid; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Synaptic Transmission; TRPV Cation Channels | 2014 |
Assessment of intraoral mucosal pain induced by the application of capsaicin.
Topics: Animals; Capsaicin; Disease Models, Animal; Hyperalgesia; Male; Nociceptors; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Trigeminal Nerve Injuries | 2014 |
Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways.
Topics: Animals; Capsaicin; Cell Line, Tumor; Cytokines; Drugs, Chinese Herbal; Female; Hyperalgesia; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Phosphorylation; Proto-Oncogene Proteins c-akt; Sarcoma; TRPV Cation Channels | 2014 |
Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Chronic Pain; Disease Models, Animal; Facial Neoplasms; Facial Pain; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Irritants; Lip Diseases; Male; Neoplasm Transplantation; Orbit; Pain Measurement; Pregabalin; Random Allocation; Rats, Wistar; Sensory System Agents; Trigeminal Neuralgia | 2014 |
TRPA1 contributes to capsaicin-induced facial cold hyperalgesia in rats.
Topics: Acetanilides; Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Cold Temperature; Electromyography; Face; Facial Pain; Hot Temperature; Hyperalgesia; Injections, Intradermal; Male; Neural Conduction; Neurons; Physical Stimulation; Purines; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents; Synaptic Transmission; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2014 |
Possible involvement of convergent nociceptive input to medullary dorsal horn neurons in intraoral hyperalgesia following peripheral nerve injury.
Topics: Animals; Capsaicin; Hyperalgesia; Male; Medulla Oblongata; Mouth; Nociceptors; Pain Measurement; Peripheral Nerve Injuries; Posterior Horn Cells; Rats; Rats, Sprague-Dawley | 2015 |
Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Blotting, Western; Capsaicin; Cnidarian Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Pyridines; Rats; Sulfones; Time Factors; TRPV Cation Channels | 2014 |
Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats.
Topics: Animals; Capsaicin; Consciousness; Grooming; Hyperalgesia; Isothiocyanates; Male; Mouth Mucosa; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Stimulation, Chemical; Time Factors | 2015 |
Antinociceptive effect of botulinum toxin type A on experimental abdominal pain.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Botulinum Toxins, Type A; Capsaicin; Colitis; Disease Models, Animal; Hyperalgesia; Male; Pain Measurement; Pain, Referred; Peritonitis; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord; Visceral Pain | 2014 |
Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats.
Topics: Analgesics; Animals; Capsaicin; Chronic Pain; Dinoprostone; Hyperalgesia; Male; Nociception; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, mu; Rotarod Performance Test; Somatostatin | 2015 |
Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Capsaicin; Disease Models, Animal; Diterpenes; Edema; Hindlimb; Hyperalgesia; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Nociceptors; Pain Threshold; Peroxidase; Reactive Oxygen Species; Sensory System Agents; Somatostatin; Tarsus, Animal; TRPV Cation Channels; X-Ray Microtomography | 2015 |
The role of TRPV1 channels in carrageenan-induced mechanical hyperalgesia in mice.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Functional Laterality; Hyperalgesia; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Sensory System Agents; Touch; TRPV Cation Channels | 2015 |
Influence of topical application of capsaicin, menthol and local anesthetics on intraoral somatosensory sensitivity in healthy subjects: temporal and spatial aspects.
Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Local; Antipruritics; Capsaicin; Dose-Response Relationship, Drug; Facial Pain; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Menthol; Pain Threshold; Sensory System Agents; Time Factors; Visual Analog Scale; Young Adult | 2015 |
Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms.
Topics: Analysis of Variance; Animal Diseases; Animals; Area Under Curve; Astrocytes; Capsaicin; Glial Fibrillary Acidic Protein; Hyperalgesia; Hypoglycemic Agents; Injections, Intraventricular; Male; Neuralgia; Nociception; Oncogene Proteins v-fos; Pain Threshold; Pioglitazone; PPAR gamma; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Thiazolidinediones | 2015 |
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.
Topics: Action Potentials; Animals; Biophysical Phenomena; Capsaicin; Cells, Cultured; CHO Cells; Cricetulus; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pain; Pain Measurement; Physical Stimulation; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2015 |
Cold and L-menthol-induced sensitization in healthy volunteers--a cold hypersensitivity analogue to the heat/capsaicin model.
Topics: Administration, Topical; Adult; Capsaicin; Cold Temperature; Female; Hand; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Male; Menthol; Pain; Pain Measurement; Pain Threshold; Skin; Skin Temperature; Time Factors | 2015 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2015 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2015 |
TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity.
Topics: Aminopyridines; Animals; Biophysical Phenomena; Capsaicin; Female; Gene Expression Regulation; Glycoproteins; Hyperalgesia; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nociception; Pain Measurement; Pain Threshold; Piperazines; Sensory Receptor Cells; Skin; Species Specificity; Trigeminal Ganglion; TRPV Cation Channels | 2015 |
A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats.
Topics: Analgesics, Opioid; Animals; Capsaicin; Conditioning, Operant; Equipment Design; Facial Pain; Female; Hyperalgesia; Morphine; Pain Measurement; Pressure; Rats, Sprague-Dawley; Touch | 2015 |
Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain.
Topics: Adult; Aged; Antipruritics; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Unmyelinated; Neuralgia; Outcome Assessment, Health Care; Prognosis | 2016 |
Effectiveness of High-Frequency Electrical Stimulation Following Sensitization With Capsaicin.
Topics: Adult; Biophysical Phenomena; Capsaicin; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Reaction Time; Sensory System Agents; Time Factors; Transcutaneous Electric Nerve Stimulation; Young Adult | 2015 |
HDAC4 is required for inflammation-associated thermal hypersensitivity.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Down-Regulation; Freund's Adjuvant; Histone Deacetylases; Hyperalgesia; Hypersensitivity; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Protein Precursors; Sensory Receptor Cells; Transcription, Genetic; TRPV Cation Channels | 2015 |
Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans.
Topics: Adult; Biophysics; Capsaicin; Electric Stimulation; Healthy Volunteers; Humans; Hyperalgesia; Long-Term Potentiation; Male; Nerve Fibers; Neural Conduction; Nociceptors; Pain; Pain Threshold; Physical Stimulation; Sensory System Agents; Skin; TRPV Cation Channels; Young Adult | 2015 |
Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.
Topics: Animals; Capsaicin; Cells, Cultured; Cyclic AMP; Female; Ganglia, Spinal; Humans; Hyperalgesia; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Parathyroid Hormone-Related Protein; Protein Kinase C-epsilon; Protein Transport; Receptor, Parathyroid Hormone, Type 1; TRPV Cation Channels; Up-Regulation | 2015 |
Capsaicin 8% Patch for Central and Peripheral Neuropathic Pain of Persons with Incomplete Spinal Cord Injury: Two Case Reports.
Topics: Adult; Aged; Capsaicin; Humans; Hyperalgesia; Male; Neuralgia; Pain Measurement; Sensory System Agents; Spinal Cord Injuries; Transdermal Patch | 2015 |
Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.
Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Male; Nerve Growth Factor; Nociception; Oxidative Stress; Pain Measurement; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Skin; TRPV Cation Channels | 2015 |
Vitamin B complex attenuated heat hyperalgesia following infraorbital nerve constriction in rats and reduced capsaicin in vivo and in vitro effects.
Topics: Animals; Calcium; Capsaicin; Carbamazepine; Constriction; Dose-Response Relationship, Drug; Drug Synergism; HEK293 Cells; Humans; Hyperalgesia; Male; Orbit; Rats; Rats, Wistar; TRPV Cation Channels; Vitamin B Complex | 2015 |
Enhanced spinal neuronal responses as a mechanism for the increased nociceptive sensitivity of interleukin-4 deficient mice.
Topics: Action Potentials; Age Factors; Animals; Capsaicin; Hyperalgesia; Interleukin-4; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pain Measurement; Pain Threshold; Physical Stimulation; Pupil Disorders; Reaction Time; Spinal Cord; Statistics, Nonparametric; Time Factors | 2015 |
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Kaolin; Knee Joint; Male; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Synovial Fluid | 2015 |
Synovial TRPV1 is upregulated by 17-β-estradiol and involved in allodynia of inflamed temporomandibular joints in female rats.
Topics: Animals; Blotting, Western; Capsaicin; Cyclooxygenase 2; Estradiol; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Nerve Growth Factor; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Temporomandibular Joint; Temporomandibular Joint Disorders; Transcriptional Activation; TRPV Cation Channels; Up-Regulation | 2015 |
Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.
Topics: Alkaloids; Analgesics; Animals; Calcium; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Evodia; Ganglia, Spinal; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Male; Medicine, Chinese Traditional; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Plant Extracts; Quinazolines; Quinolines; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2016 |
Characterizing pinprick-evoked brain potentials before and after experimentally induced secondary hyperalgesia.
Topics: Adult; Capsaicin; Cerebral Cortex; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Nociception; Pain; Pain Measurement; Physical Stimulation; Young Adult | 2015 |
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; Female; Flagellin; Ganglia, Spinal; Humans; Hyperalgesia; Lidocaine; Male; Mice; Mice, Knockout; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuralgia; Neurofilament Proteins; Neurons; Paclitaxel; Peripheral Nerve Injuries; Sensory System Agents; Toll-Like Receptor 5 | 2015 |
Peripheral sensitization reduces laser-evoked potential habituation.
Topics: Capsaicin; Central Nervous System; Electroencephalography; Evoked Potentials; Female; Habituation, Psychophysiologic; Hand; Humans; Hyperalgesia; Lasers; Male; Pain; Peripheral Nerves; Reaction Time; Reference Standards; Sensation; Young Adult | 2015 |
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
Topics: Animals; Bicuculline; Capsaicin; Excitatory Amino Acid Antagonists; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Nerve Fibers, Unmyelinated; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, GABA-B | 2016 |
Nonparalytic botulinum molecules for the control of pain.
Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Cell Count; Cell Proliferation; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Keratinocytes; Male; Motor Activity; Nerve Fibers, Unmyelinated; Neuralgia; Neuromuscular Agents; Pain Measurement; Pain Threshold; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn | 2016 |
Involvement of mast cells and proteinase-activated receptor 2 in oxaliplatin-induced mechanical allodynia in mice.
Topics: Animals; Antineoplastic Agents; Capsaicin; Cell Degranulation; Hyperalgesia; Male; Mast Cells; Mice, Inbred C57BL; Organoplatinum Compounds; Oxaliplatin; Receptor, PAR-2; Sensory System Agents | 2016 |
The evaluation of neural and vascular hyper-reactivity for sensitive skin.
Topics: Adolescent; Adult; Capsaicin; Female; Genetic Predisposition to Disease; Humans; Hyperalgesia; Lactic Acid; Male; Middle Aged; Neurovascular Coupling; Pain Perception; Sensory System Agents; Skin; Skin Tests; TRPV Cation Channels; Young Adult | 2016 |
TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception.
Topics: Animals; Calcium; Capsaicin; CHO Cells; Conditioning, Operant; Cricetulus; Cyclin-Dependent Kinase 5; Drinking; Gene Expression; HEK293 Cells; Hot Temperature; Humans; Hydrogen-Ion Concentration; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nociception; Pain Threshold; Patch-Clamp Techniques; Phosphorylation; Rats; Trigeminal Ganglion; TRPV Cation Channels | 2016 |
The prokineticin Bv8 sensitizes cutaneous terminals of female mice to heat.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Female; Gastrointestinal Hormones; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Nerve Fibers; Neuropeptides; Nociceptors; Peripheral Nerves; Skin | 2016 |
Enhanced Area of Secondary Hyperalgesia in Women with Multiple Stressful Life Events: A Pilot Study.
Topics: Adolescent; Capsaicin; Female; Humans; Hyperalgesia; Life Change Events; Pain Measurement; Pilot Projects; Stress, Psychological; Young Adult | 2016 |
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.
Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Capsaicin; Disease Models, Animal; Electric Stimulation; Hyperalgesia; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; Magnetic Resonance Imaging; Nociception; Osteoarthritis, Knee; Pain; Rats, Sprague-Dawley | 2016 |
Contribution of capsaicin-sensitive primary afferents to mechanical hyperalgesia induced by ventral root transection in rats: the possible role of BDNF.
Topics: Animals; Brain-Derived Neurotrophic Factor; Capsaicin; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pain Threshold; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory System Agents; Spinal Nerve Roots; Statistics, Nonparametric; Transfection | 2016 |
Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways.
Topics: Adult; Afferent Pathways; Brain; Capsaicin; Central Nervous System Sensitization; Electric Stimulation; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Nociceptors; Pain; Pain Measurement; Reaction Time; ROC Curve; Signal-To-Noise Ratio; Skin; Young Adult | 2016 |
The Detection of Small-Fiber Neuropathies in Burning Mouth Syndrome and Iatrogenic Lingual Nerve Injuries: Use of Quantitative Sensory Testing.
Topics: Adult; Aged; Aged, 80 and over; Burning Mouth Syndrome; Capsaicin; Cold Temperature; Ethyl Chloride; Female; Hot Temperature; Humans; Hyperalgesia; Hypesthesia; Iatrogenic Disease; Lingual Nerve Injuries; Male; Middle Aged; Nerve Fibers; Pain Measurement; Pain Perception; Paresthesia; Sensory System Agents; Thermosensing; Tongue | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels | 2016 |
Impaired diffuse noxious inhibitory controls in specific alternation of rhythm in temperature-stressed rats.
Topics: Animals; Capsaicin; Diffuse Noxious Inhibitory Control; Heat-Shock Response; Hyperalgesia; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley | 2016 |
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.
Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Edema; Hyperalgesia; Knee Joint; Male; Mice, Inbred C57BL; Mice, Knockout; Neurogenic Inflammation; Pain; Protein Precursors; Receptor, PAR-2; Receptors, Neurokinin-1; Substance P; Tachykinins; Touch; TRPV Cation Channels; Tryptases | 2016 |
Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates.
Topics: Animals; Capsaicin; Cerebellum; Female; Frontal Lobe; Gyrus Cinguli; Hot Temperature; Humans; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis; Magnetic Resonance Imaging; Male; Pain; Somatosensory Cortex; Tail; Thermosensing | 2016 |
Multiple impairments of cutaneous nociceptor function induced by cardiotoxic doses of Adriamycin in the rat.
Topics: Animals; Antibiotics, Antineoplastic; Biomarkers; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Cardiotoxicity; Carrageenan; Disease Models, Animal; Doxorubicin; Hyperalgesia; Male; Motor Activity; Mustard Plant; Nociception; Plant Oils; Rats, Wistar; Regional Blood Flow; Sensory Receptor Cells; Skin; Time Factors; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Vasodilation | 2016 |
Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Pain Measurement; Rats; Rats, Sprague-Dawley | 2016 |
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25 | 2016 |
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Hyperalgesia; Indenes; K Cl- Cotransporters; Lipopolysaccharides; Male; MAP Kinase Signaling System; Muscimol; Nociception; Pain Measurement; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Potassium Chloride Symporter Inhibitors; Spinal Cord Injuries; Symporters; Time Factors | 2016 |
Stimulating TRPV1 externalization and synthesis in dorsal root ganglion neurons contributes to PGE2 potentiation of TRPV1 activity and nociceptor sensitization.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Male; Neurons; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; TRPV Cation Channels | 2017 |
Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cadherins; Capsaicin; Disease Models, Animal; Electroshock; Extracellular Signal-Regulated MAP Kinases; GABA Agonists; Hyperalgesia; Immunoglobulin G; K Cl- Cotransporters; Male; MAP Kinase Signaling System; Muscimol; Nociception; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, trkB; Spinal Cord Injuries; Symporters | 2017 |
Neurogenic hyperalgesia: illuminating its mechanisms with an infrared laser.
Topics: Capsaicin; Hyperalgesia; Neurogenesis; Skin | 2016 |
Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.
Topics: Animals; Capsaicin; Cyclopentanes; Disease Models, Animal; Hyperalgesia; Liver; Male; Mice; Morpholines; Nociception; Pain Measurement; Pain Threshold; Pentazocine; Receptors, sigma; Sigma-1 Receptor | 2016 |
SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Ganglia, Spinal; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Mice; Mice, Knockout; Microfilament Proteins; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neuralgia; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Sensory System Agents; Spinal Cord; TRPV Cation Channels | 2016 |
Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers.
Topics: Administration, Oral; Adult; Analgesics; Capsaicin; Cross-Over Studies; Dermatitis, Contact; Electroencephalography; Evoked Potentials, Somatosensory; Female; Healthy Volunteers; Humans; Hyperalgesia; Lasers; Male; Middle Aged; Pain; Pain Measurement; Placebos; Single-Blind Method; Skin; Treatment Outcome; Ultraviolet Rays; Young Adult | 2017 |
Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study.
Topics: Adult; Capsaicin; Female; Healthy Volunteers; Histamine; Humans; Hyperalgesia; Male; Nociceptors; Pain Measurement; Paresthesia; Pruritus; Skin; Young Adult | 2017 |
Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1'-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Capsaicin; Heterocyclic Compounds, 3-Ring; Hyperalgesia; Ketoprofen; Mice; Nociception; Pain; Pyrimidines; Spiro Compounds | 2017 |
Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats.
Topics: Animals; Antipruritics; Capsaicin; Consciousness; Female; Hyperalgesia; Nerve Fibers; Neurotransmitter Agents; Nociceptors; Pain; Peptides; Rats, Wistar; Sciatic Nerve; Sensory Receptor Cells; Somatostatin | 2017 |
Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats.
Topics: Animals; Capsaicin; Chronic Disease; Electric Stimulation; Evoked Potentials; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Male; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; TRPV Cation Channels | 2008 |
Morphine inhibits herpetic allodynia through mu-opioid receptors induced in Abeta-fiber neurons.
Topics: Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Mice; Mice, Inbred C57BL; Morphine; Narcotics; Neurons, Afferent; Pain Measurement; Pain Threshold; Receptors, Opioid, mu; Sensory System Agents; Simplexvirus | 2008 |
Central representation of cold-evoked pain relief in capsaicin induced pain: an event-related fMRI study.
Topics: Adult; Capsaicin; Cold Temperature; Evoked Potentials, Somatosensory; Humans; Hyperalgesia; Hypothermia, Induced; Magnetic Resonance Imaging; Male; Middle Aged; Somatosensory Cortex; Young Adult | 2008 |
Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion Buthus martensi Karch.
Topics: Animals; Capsaicin; Diterpenes; Edema; Hindlimb; Hyperalgesia; Immunohistochemistry; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Spinal Cord | 2008 |
Contralateral hyperalgesia and allodynia following intradermal capsaicin injection in man.
Topics: Adult; Aged; Arthritis, Rheumatoid; Capsaicin; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Neural Pathways; Pain Measurement; Pain, Referred | 2008 |
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
Topics: Analysis of Variance; Animals; Blotting, Western; Capsaicin; Cell Line; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; G-Protein-Coupled Receptor Kinases; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Pain Threshold; Peroxidase; Proto-Oncogene Proteins c-fos; Visceral Afferents | 2009 |
Ultraviolet-B induced inflammation of human skin: characterisation and comparison with traditional models of hyperalgesia.
Topics: Adult; Burns; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Inflammation; Male; Models, Neurological; Nociceptors; Pain Threshold; Radiation Dosage; Sensory Receptor Cells; Sensory System Agents; Skin; Sunburn; Time Factors; Ultraviolet Rays; Young Adult | 2009 |
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Topics: Administration, Oral; Analgesics; Animals; Arachidonic Acids; Calcium; Capsaicin; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hyperalgesia; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; TRPV Cation Channels | 2008 |
Surgical incision can alter capsaicin-induced central sensitization in rat brainstem nociceptive neurons.
Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Capsaicin; Hyperalgesia; Lidocaine; Male; Mechanoreceptors; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Temporomandibular Joint; Trigeminal Nucleus, Spinal | 2008 |
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
Topics: Alcoholic Neuropathy; Animals; Behavior, Animal; Capsaicin; Catecholamines; Clorgyline; Desipramine; Enzyme Inhibitors; Ethanol; Ganglia, Spinal; Hyperalgesia; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; Nociceptors; Norepinephrine Plasma Membrane Transport Proteins; Oligonucleotides, Antisense; Pargyline; Rats; Rats, Sprague-Dawley; Sensory System Agents | 2008 |
Change of AMPA receptors in spinal nociceptive synapses during inflammatory hyperalgesia.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Humans; Hyperalgesia; Inflammation; Long-Term Potentiation; Nociceptors; Receptors, AMPA; Sensory System Agents; Spinal Cord; Synapses; Synaptic Transmission | 2008 |
Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Corticosterone; Defecation; Electromyography; Endocannabinoids; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Microscopy, Fluorescence; Models, Animal; Morpholines; Naphthalenes; Pain Threshold; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Spectrum Analysis; Stress, Psychological; TRPV Cation Channels | 2009 |
Postherpetic neuralgia--fighting pain with fire.
Topics: Administration, Cutaneous; Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Neuralgia, Postherpetic; Nociceptors; Pain Measurement; Randomized Controlled Trials as Topic; Sensory Receptor Cells; Sensory System Agents | 2008 |
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
Topics: Amino Acids; Animals; Capsaicin; Colforsin; Electrophysiological Phenomena; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Nociceptors; Pain; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; TRPV Cation Channels; Xanthenes | 2009 |
Involvement of neuronal, inducible and endothelial nitric oxide synthases in capsaicin-induced muscle hypersensitivity.
Topics: Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Immunohistochemistry; Male; Masseter Muscle; Myositis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Time Factors; Trigeminal Caudal Nucleus; Up-Regulation | 2009 |
Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents.
Topics: Analgesics, Non-Narcotic; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Intracellular Fluid; Mice; Nefopam; Potassium Chloride; Rats; Sensory Receptor Cells; Sensory System Agents; TRPV Cation Channels | 2009 |
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.
Topics: Animals; Capsaicin; Cell Line, Transformed; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hyperalgesia; Male; Mice; Pain Measurement; Pain Threshold; Protein Binding; Pyrazoles; Reaction Time; Receptors, Serotonin; Serotonin Agents | 2009 |
Persistent pain is dependent on spinal mitochondrial antioxidant levels.
Topics: Analysis of Variance; Animals; Antioxidants; Capsaicin; Ditiocarb; Dose-Response Relationship, Drug; Foot; Free Radical Scavengers; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Knockout; Mitochondria; Pain; Pain Measurement; Pain Threshold; Reactive Oxygen Species; Spinal Cord; Stilbamidines; Superoxide Dismutase | 2009 |
Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue.
Topics: Adult; Analysis of Variance; Capsaicin; Drug Interactions; Glutamic Acid; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Tendons; Young Adult | 2009 |
TPRV1 expression defines functionally distinct pelvic colon afferents.
Topics: Action Potentials; Animals; Biophysics; Capsaicin; Colon; Female; Ganglia, Spinal; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mustard Plant; Pain Threshold; Pelvis; Physical Stimulation; Plant Oils; Sensory Receptor Cells; Sensory System Agents; Statistics, Nonparametric; TRPV Cation Channels; Visceral Afferents | 2009 |
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.
Topics: Alkynes; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Ceruletide; Cystathionine gamma-Lyase; Ganglia, Spinal; Glycine; Hydrogen Sulfide; Hyperalgesia; Immunohistochemistry; Male; Mibefradil; Mice; Nociceptors; Oncogene Proteins v-fos; Pancreas; Pancreatitis, Acute Necrotizing; Rats; Rats, Wistar; Sulfides | 2009 |
Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers.
Topics: Animals; Capsaicin; Glutamic Acid; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sensory System Agents; Time Factors; TRPV Cation Channels | 2009 |
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
Topics: Analgesics, Opioid; Animals; Bicuculline; Blood Pressure; Capsaicin; Disease Models, Animal; Drug Resistance; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Glycine; Hyperalgesia; Male; Morphine; Nonlinear Dynamics; Oncogene Proteins v-fos; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Strychnine | 2009 |
Independent psychophysical measurement of experimental modulations in the somatotopy of cutaneous heat-pain stimuli.
Topics: Adult; Brain Mapping; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Lasers; Male; Neuropsychological Tests; Nociceptors; Pain; Perception; Physical Stimulation; Psychophysics; Sensory System Agents; Somatosensory Cortex; Young Adult | 2009 |
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Topics: Action Potentials; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glutamic Acid; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Naloxone; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; TRPV Cation Channels | 2009 |
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Brain; Capsaicin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Hyperalgesia; Mice; Morpholines; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pentazocine; Physical Stimulation; Protein Binding; Radioligand Assay; Reaction Time; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Tritium | 2009 |
Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.
Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Pain Threshold; Physical Stimulation; RNA, Messenger; Time Factors; TRPM Cation Channels; Up-Regulation | 2009 |
Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice.
Topics: Animals; Anisoles; Capsaicin; DNA; Ethylenediamines; Female; Hyperalgesia; Mice; Mice, Knockout; Morpholines; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Piperazines; Polymerase Chain Reaction; Propylamines; Reaction Time; Receptors, sigma; Sensory Receptor Cells; Sensory System Agents; Sigma-1 Receptor; Spinal Cord | 2009 |
Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Eugenol; Gene Expression Regulation; Hyperalgesia; Jaw; Lectins; Male; Masticatory Muscles; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reflex; Sodium Channels; Tetrodotoxin; Tooth; Trigeminal Ganglion; Trigeminal Nerve; TRPV Cation Channels | 2009 |
Differential effect of capsaicin treatment on pain-related behaviors after plantar incision.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Foot; Hindlimb; Hot Temperature; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Wound Healing | 2009 |
Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia.
Topics: Adult; Analysis of Variance; Attention; Capsaicin; Female; Humans; Hyperalgesia; Male; Neuropsychological Tests; Pain; Pain Measurement; Perception; Photic Stimulation; Physical Stimulation; Sensory System Agents; Task Performance and Analysis; Young Adult | 2009 |
Differentiating thermal allodynia and hyperalgesia using dynamic hot and cold plate in rodents.
Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Cold Temperature; Dimethyl Sulfoxide; Escape Reaction; Hindlimb; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates.
Topics: Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biophysics; Calcium-Binding Proteins; Capsaicin; Electric Stimulation; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Interleukin-6; Macrophage Colony-Stimulating Factor; Male; Matrix Metalloproteinase 3; Microfilament Proteins; Microglia; Minocycline; Nerve Fibers, Unmyelinated; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Sciatic Nerve; Time Factors | 2009 |
PGE(2)-induced lasting nociception to heat: evidences for a selective involvement of A-delta fibres in the hyperpathic component of hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dimethyl Sulfoxide; Dinoprostone; Hot Temperature; Hyperalgesia; Indomethacin; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar | 2010 |
Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.
Topics: Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hindlimb; Hyperalgesia; Male; Oligopeptides; Pain Measurement; Peptides, Cyclic; Physical Stimulation; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sensory System Agents; Temperature; TRPV Cation Channels | 2009 |
Role of RVM neurons in capsaicin-evoked visceral nociception and referred hyperalgesia.
Topics: Abdomen; Animals; Behavior, Animal; Blood Pressure; Capsaicin; Colon; Electrophysiology; Hyperalgesia; Male; Medulla Oblongata; Microelectrodes; Microinjections; Neurons; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.
Topics: Acrylamides; Afferent Pathways; Animals; Ankyrins; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Hyperalgesia; Injections, Intramuscular; Male; Masticatory Muscles; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice.
Topics: Analgesics; Animals; Bradykinin; Capsaicin; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hot Temperature; Hyperalgesia; Immersion; Inflammation; Male; Mice; Motor Activity; Organoselenium Compounds; Pain Measurement; Reaction Time; Tetradecanoylphorbol Acetate | 2009 |
Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus.
Topics: Adult; Analysis of Variance; Body Temperature; Capsaicin; Cerebral Cortex; Electric Stimulation; Electroencephalography; Esophagus; Evoked Potentials, Somatosensory; Female; Humans; Hydrochloric Acid; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Rectum | 2010 |
Axotomy depletes intracellular calcium stores in primary sensory neurons.
Topics: Animals; Axons; Axotomy; Caffeine; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Central Nervous System Stimulants; Endoplasmic Reticulum; Hyperalgesia; Ionomycin; Ligation; Male; Nerve Degeneration; Pain Measurement; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Sciatic Nerve; Sensory Receptor Cells; Spinal Nerves; Thapsigargin | 2009 |
Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Hyperalgesia; Intermediate Filament Proteins; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nestin; Pain Measurement; Pain Threshold; Peptide Fragments; Physical Stimulation; Receptor Activity-Modifying Protein 1; Receptor Activity-Modifying Proteins; Sensory System Agents | 2009 |
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.
Topics: Action Potentials; Afferent Pathways; Animals; Bradykinin; Capsaicin; Colitis; Colon; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroanatomical Tract-Tracing Techniques; Nodose Ganglion; Pain Measurement; Pelvis; Pressure; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Nerves; Stimulation, Chemical; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel | 2009 |
Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism.
Topics: Acupuncture Points; Adrenergic alpha-Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Electroacupuncture; Functional Laterality; Hyperalgesia; Male; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phentolamine; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Touch | 2009 |
Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Male; Mice; Motor Activity; Neurons; Oleanolic Acid; Opioid Peptides; Pain; Pain Measurement; Physical Stimulation; Protein Kinase C; Psychomotor Performance; Rats; Rats, Wistar; Serotonin; Signal Transduction; TRPV Cation Channels | 2009 |
[The role of capsaicin-sensitive primary afferents in experimental sciatic pain].
Topics: Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Hyperalgesia; Intervertebral Disc Displacement; Male; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sciatica; Spinal Nerve Roots | 2009 |
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
Topics: Analgesics; Animals; Benzimidazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Piperidines | 2010 |
Effect of capsaicin treatment on nociceptors in rat glabrous skin one day after plantar incision.
Topics: Action Potentials; Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Hyperalgesia; Lectins; Male; Nerve Fibers; Neural Conduction; Neurofilament Proteins; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Sensory System Agents; Skin; Statistics, Nonparametric; Stimulation, Chemical; Ubiquitin Thiolesterase | 2010 |
Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation.
Topics: Adult; Asian People; Black or African American; Capsaicin; Female; Hispanic or Latino; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Neurogenic Inflammation; Pain; Pain Measurement; Pain Threshold; Pruritus; Regional Blood Flow; Sensory Thresholds; Skin; White People; Young Adult | 2010 |
Nociceptive sensitization by complement C5a and C3a in mouse.
Topics: Action Potentials; Analysis of Variance; Animals; Calcineurin; Calcium; Capsaicin; Complement C3a; Complement C5a; Dose-Response Relationship, Drug; Exploratory Behavior; Ganglia, Spinal; Humans; Hyperalgesia; Immunologic Factors; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Nerve Fibers; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; RNA, Messenger; Sensory Receptor Cells; Skin | 2010 |
Curcumin produces an antihyperalgesic effect via antagonism of TRPV1.
Topics: Animals; Capsaicin; Cell Line; Curcumin; Facial Pain; Hot Temperature; Humans; Hyperalgesia; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney; Male; Nociceptors; Nose; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; TRPV Cation Channels | 2010 |
Topically applied capsaicin inhibits sensitivity to touch but not to warmth or heat-pain in the region of secondary mechanical hyperalgesia.
Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Female; Functional Laterality; Humans; Hyperalgesia; Male; Middle Aged; Sensory System Agents; Sensory Thresholds; Touch; Young Adult | 2009 |
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Carrageenan; Hyperalgesia; Inflammation; Mice; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels | 2010 |
Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray.
Topics: Analgesia; Analgesics; Animals; Benzoxazines; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Nociceptors; Periaqueductal Gray; Rats; Receptor, Cannabinoid, CB1; RNA, Messenger; TRPV Cation Channels; Up-Regulation | 2010 |
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2010 |
Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models.
Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Ketamine; Pain; Pain Measurement; Sensory System Agents; Skin | 2010 |
Trigeminal antihyperalgesic effect of intranasal carbon dioxide.
Topics: Acid Sensing Ion Channels; Administration, Intranasal; Animals; Behavior, Animal; Capsaicin; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hyperalgesia; Male; Nasal Mucosa; Nerve Tissue Proteins; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channels; Trigeminal Nerve; TRPV Cation Channels | 2010 |
Luminal serotonin time-dependently modulates vagal afferent driven antinociception in response to colorectal distention in rats.
Topics: Afferent Pathways; Analgesics; Animals; Capsaicin; Colon; Dilatation, Pathologic; Food Hypersensitivity; Granisetron; Hyperalgesia; Intestinal Mucosa; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Time Factors; Vagotomy; Vagus Nerve | 2011 |
Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon.
Topics: Animals; Capsaicin; Colon; Fenclonine; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Male; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin; TRPV Cation Channels; Viscera | 2010 |
Sensitized peripheral nociception in experimental diabetes of the rat.
Topics: Action Potentials; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Diabetes Mellitus, Experimental; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; In Vitro Techniques; Male; Nerve Fibers; Nociceptors; Pain Measurement; Pain Threshold; Rats; Reaction Time; Sciatic Nerve; Skin; Streptozocin; Substance P | 2010 |
Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception.
Topics: Animals; Capsaicin; Dihydroxytryptamines; Hot Temperature; Hyperalgesia; Male; Models, Animal; Muscle, Skeletal; Naloxone; Nerve Fibers, Unmyelinated; Nociceptors; Rats; Rats, Sprague-Dawley; Reflex; Saline Solution, Hypertonic; Sciatic Nerve; Time Factors | 2010 |
The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.
Topics: Acute Disease; Animals; Benzamidines; Capsaicin; Ceruletide; Disease Models, Animal; Gene Expression Regulation; Guanidines; Hyperalgesia; Male; Mice; Oligopeptides; Pain; Pancreatitis; Proto-Oncogene Proteins c-fos; Receptor, PAR-2; Spinal Cord; TRPV Cation Channels | 2010 |
Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Capsaicin; Conditioning, Operant; Disease Models, Animal; Facial Pain; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley | 2011 |
Eriodictyol: a flavonoid antagonist of the TRPV1 receptor with antioxidant activity.
Topics: Analgesics; Animals; Antioxidants; Capsaicin; Flavanones; Flavonoids; Hyperalgesia; Mice; Pain; Rats; TRPV Cation Channels | 2011 |
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Fixatives; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Mice; Mice, Knockout; Nociceptors; Pain; Sensory System Agents; Vesicular Glutamate Transport Protein 2 | 2010 |
Cutaneous limb inflammation produces analgesia to pressure pain in the ipsilateral forehead of healthy volunteers.
Topics: Adolescent; Adult; Analgesia; Capsaicin; Complex Regional Pain Syndromes; Female; Forearm; Forehead; Functional Laterality; Humans; Hyperalgesia; Inflammation; Irritants; Pain; Pain Perception; Pain Threshold; Pressure; Skin; Young Adult | 2011 |
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat.
Topics: Acetanilides; Analysis of Variance; Animals; Ankyrins; Calcium Channels; Capsaicin; Cholecystokinin; Cinnamomum zeylanicum; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; N-Methylaspartate; Pain Measurement; Peripheral Nervous System Diseases; Purines; Rats; Rats, Wistar; Sleep Deprivation; Spinal Cord; TRPA1 Cation Channel; TRPC Cation Channels | 2011 |
Nociceptive cortical responses during capsaicin-induced tactile allodynia in mice with spinal dorsal column lesioning.
Topics: Animals; Capsaicin; Functional Laterality; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Sensory System Agents; Somatosensory Cortex; Spinal Cord | 2011 |
Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity.
Topics: Capsaicin; Drug Synergism; Female; Humans; Hyperalgesia; Male; Middle Aged; Multiple Chemical Sensitivity; Pain Measurement | 2011 |
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation.
Topics: Animals; Antineoplastic Agents; Atropine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chromatography, High Pressure Liquid; Cisplatin; Cricetinae; Cricetulus; Dipeptides; Disease Models, Animal; Drug Interactions; Ganglia, Spinal; Gene Expression Regulation; Guinea Pigs; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Piperazines; Pulmonary Artery; Quinazolines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensory Receptor Cells; Spectrometry, Mass, Electrospray Ionization; Superoxides; Tissue Culture Techniques; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2011 |
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Capsaicin; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Humans; Hyperalgesia; Inflammation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nifedipine; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Plant Oils; Pregnenolone; Sensory Receptor Cells; Telemetry; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPM Cation Channels | 2011 |
Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Genetic Therapy; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Morphine; Narcotics; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Second Messenger Systems; Spinal Cord; Stress, Mechanical | 2011 |
Synthesis and pharmacological evaluation of a potent and selective σ1 receptor antagonist with high antiallodynic activity.
Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Dioxanes; Disease Models, Animal; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Hyperalgesia; Male; Mice; Rats; Receptors, sigma; Sigma-1 Receptor | 2011 |
Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
Topics: Animals; Capsaicin; Cyclic AMP Response Element-Binding Protein; Hyperalgesia; Immunohistochemistry; Male; Pain; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sumatriptan; Trigeminal Caudal Nucleus; Tryptamines | 2011 |
Central nervous system mast cells in peripheral inflammatory nociception.
Topics: Animals; Capsaicin; Carrageenan; Cell Count; Cell Degranulation; Central Nervous System; Female; Hyperalgesia; Long-Term Potentiation; Lumbar Vertebrae; Male; Mast Cells; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Nociceptors; Rats; Rats, Sprague-Dawley; Synapses; Thalamus; Time Factors | 2011 |
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Allyl Compounds; Animals; Ankyrins; Behavior, Animal; Calcium; Calcium Channels; Capsaicin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Hydrogen-Ion Concentration; Hyperalgesia; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isocyanates; Maleimides; Membrane Potentials; Mice; Mice, Inbred Strains; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Nociception; Nociceptive Pain; Oocytes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spermine; Synaptic Transmission; Tachyphylaxis; Transient Receptor Potential Channels; Trigeminal Caudal Nucleus; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Xenopus laevis | 2011 |
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.
Topics: Action Potentials; Anemia, Sickle Cell; Animals; Capsaicin; Disease Models, Animal; Female; Humans; Hyperalgesia; Hypoxia; Isoquinolines; Male; Mice; Mice, Inbred Strains; Microelectrodes; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; TRPV Cation Channels; Urea | 2011 |
Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain.
Topics: Animals; Benzamides; Capsaicin; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Mice; Neuralgia; Quinolones; Tissue Distribution; TRPV Cation Channels | 2011 |
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
Topics: Administration, Oral; Amides; Animals; Capsaicin; Cyclohexanols; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Isoxazoles; Microsomes, Liver; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
Intradermal capsaicin as a neuropathic pain model in patients with unilateral sciatica.
Topics: Adult; Capsaicin; Case-Control Studies; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Models, Theoretical; Pain; Pain Measurement; Sciatica; Sensory System Agents | 2012 |
Capsaicin prevents the hyperalgesia induced by peripheral group I mGluRs activation.
Topics: Afferent Pathways; Animals; Capsaicin; Hyperalgesia; Male; Nerve Fibers; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sciatic Nerve; Touch | 2011 |
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Topics: Analysis of Variance; Anilides; Animals; Ankyrins; Antineoplastic Agents, Phytogenic; Capsaicin; Carbazoles; Central Nervous System; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Oligopeptides; Paclitaxel; Pain Measurement; Physical Stimulation; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, PAR-2; Sulfonamides; Time Factors; TRPV Cation Channels; Tryptases; Type C Phospholipases | 2011 |
Sex differences in neuropeptide content and release from rat dental pulp.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dental Pulp; Female; Hyperalgesia; Male; Mice; Nerve Growth Factor; Neurogenic Inflammation; Proestrus; Rats; Sex Characteristics | 2011 |
Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1(TRPV1) and inflammatory mediators.
Topics: Animals; Blood Glucose; Body Weight; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Diterpenes; Glucose Tolerance Test; Hyperalgesia; Hyperglycemia; Inflammation Mediators; Injections, Intraperitoneal; Injections, Spinal; Insulin; Microglia; Pain; Posterior Horn Cells; Rats; Streptozocin; TRPV Cation Channels | 2011 |
Dissecting itch and pain sensations in human skin.
Topics: Acute Pain; Capsaicin; Female; Histamine; Humans; Hyperalgesia; Male; Skin | 2011 |
Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice.
Topics: Animals; Anthracenes; Capsaicin; Carbamates; Hyperalgesia; KCNQ2 Potassium Channel; Magnesium Sulfate; Mice; Mice, Transgenic; Phenylenediamines; Prosencephalon; Proto-Oncogene Proteins c-fos; Somatosensory Cortex; Visceral Pain | 2011 |
Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Capsaicin; Hyperalgesia; Male; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Neurons; Nociception; Pain Threshold; Patch-Clamp Techniques; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sensory System Agents | 2012 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.
Topics: Ambroxol; Aniline Compounds; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Hot Temperature; Hyperalgesia; Injections, Spinal; Ischemia; Male; NAV1.8 Voltage-Gated Sodium Channel; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Time Factors | 2012 |
Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat.
Topics: Animals; Capsaicin; Female; Hyperalgesia; Ketanserin; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan | 2012 |
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice.
Topics: Acetone; Analgesics, Opioid; Animals; Capsaicin; Clomipramine; Disease Models, Animal; Formaldehyde; Hyperalgesia; Irritants; Male; Mice; Nociceptors; Orbit; Pruritus; Selective Serotonin Reuptake Inhibitors; Sensory System Agents; Tramadol; Transient Receptor Potential Channels; Trigeminal Nerve Injuries; Trigeminal Neuralgia; TRPA1 Cation Channel; TRPV Cation Channels; Vibrissae | 2011 |
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism.
Topics: Acetanilides; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Drug Hypersensitivity; Glutathione; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Paclitaxel; Peripheral Nervous System Diseases; Purines; Pyrroles; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Absence of mechanical hyperalgesia after exercise (delayed onset muscle soreness) in neonatally capsaicin-treated rats.
Topics: Animals; Animals, Newborn; Capsaicin; Hyperalgesia; Male; Muscle Contraction; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
Discovery of novel 5,5-diarylpentadienamides as orally available transient receptor potential vanilloid 1 (TRPV1) antagonists.
Topics: Alkadienes; Amides; Analgesics; Animals; Blood-Brain Barrier; Calcium; Capsaicin; Dogs; Epstein-Barr Virus Nuclear Antigens; Haplorhini; HEK293 Cells; Humans; Hyperalgesia; Male; Microsomes, Liver; Neuralgia; Quinolones; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; TRPV Cation Channels | 2012 |
Effects of perceived and exerted pain control on neural activity during pain relief in experimental heat hyperalgesia: a fMRI study.
Topics: Adult; Brain; Capsaicin; Cerebral Cortex; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Pain; Pain Management; Pain Measurement; Perception; Prefrontal Cortex; Young Adult | 2012 |
Multiple chemical sensitivity: on the scent of central sensitization.
Topics: Adult; Capsaicin; Central Nervous System Sensitization; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Multiple Chemical Sensitivity; Pain Measurement; Surveys and Questionnaires | 2013 |
Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity.
Topics: Adiponectin; Animals; Capsaicin; Carrageenan; Down-Regulation; Edema; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Morphine; Nitric Oxide Synthase Type II; Nociception; Obesity; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Zucker; Receptors, Leptin; RNA, Messenger; Spinal Cord; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Alterations in microglia and astrocytes in the trigeminal nucleus caudalis by repetitive TRPV1 stimulation on the trigeminal nociceptors.
Topics: Animals; Astrocytes; Behavior, Animal; Calcium-Binding Proteins; Capsaicin; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Microfilament Proteins; Microglia; Nociceptors; Rats; Rats, Sprague-Dawley; Sensory System Agents; Trigeminal Caudal Nucleus; TRPV Cation Channels | 2012 |
7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersen
Topics: Analgesics; Animals; Benzothiazoles; Body Temperature; Body Temperature Regulation; Capsaicin; CHO Cells; Cricetinae; Fever; Humans; Hyperalgesia; Hypersensitivity; Male; Mice; Mice, Inbred C57BL; Pyrimidines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiones; Transient Receptor Potential Channels; TRPV Cation Channels | 2012 |
Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel transient receptor potential vanilloid 1 antagonist.
Topics: Animals; Benzoxazines; Body Temperature; Capsaicin; Carrageenan; Central Nervous System Stimulants; HEK293 Cells; Humans; Hyperalgesia; Male; Pyridines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2012 |
Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.
Topics: Analgesics; Animals; Body Temperature; Bronchoconstriction; Capsaicin; Edema; Female; Hyperalgesia; Hypothermia; Inflammation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neuralgia; Pain Measurement; Respiratory System; Sciatic Nerve; TRPV Cation Channels | 2012 |
Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.
Topics: Action Potentials; Analysis of Variance; Anilides; Animals; Capsaicin; Cell Line, Tumor; Cell Movement; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Guanosine Diphosphate; Hyperalgesia; Lysophospholipids; Male; Melanoma; Mice; Organophosphonates; Pain Threshold; Patch-Clamp Techniques; Pertussis Toxin; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sensory Receptor Cells; Sensory System Agents; Sphingosine; Thionucleotides; Time Factors; Wound Healing | 2012 |
Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Capsaicin; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Humans; Hyperalgesia; Lasers; Male; Middle Aged; Morphine; Oxycodone; Skin; Treatment Outcome; Ultraviolet Rays | 2012 |
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.
Topics: Anesthetics, Local; Animals; Antipruritics; Capsaicin; Disease Models, Animal; Drug Administration Routes; Drug Therapy, Combination; Hyperalgesia; Lidocaine; Male; Neuralgia; Peripheral Nerves; Rats; Rats, Sprague-Dawley | 2012 |
Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons.
Topics: Animals; Benzyl Alcohols; Capsaicin; Diabetic Neuropathies; Glucosides; Hyperalgesia; Rats; Sensory Receptor Cells; Streptozocin | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice.
Topics: Animals; Behavior, Animal; Calcium Channels; Capsaicin; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Ganglia, Spinal; Hyperalgesia; Isothiocyanates; Male; Menthol; Mice; Mice, Inbred C57BL; Nociception; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2012 |
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endocannabinoids; Formaldehyde; Hyperalgesia; Indoles; Male; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid | 2012 |
Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation.
Topics: Anesthetics, Local; Animals; Capsaicin; Gene Expression; Hyperalgesia; Lidocaine; Male; Mandibular Nerve; Myelin Sheath; Nerve Regeneration; Neuralgia; Nociceptors; Pain Management; Pain Threshold; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Trigeminal Nerve Injuries; TRPV Cation Channels | 2012 |
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxylic Acids; Diazepam; Endpoint Determination; GABA Antagonists; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Pain; Physical Stimulation; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 2012 |
Temporal regularity determines the impact of electrical stimulation on tactile reactivity and response to capsaicin in spinally transected rats.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Electric Stimulation; Electroshock; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinal Cord Injuries; Time Factors; Touch | 2012 |
De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion.
Topics: Animals; Brachial Plexus; Brain Stem; Capsaicin; Cholera Toxin; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Microscopy, Confocal; Neural Pathways; Peripheral Nerve Injuries; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2013 |
Stimulation of cutaneous low threshold mechanoreceptors in mice after intracolonic capsaicin increases spinal c-Fos labeling in an NKCC1-dependent fashion.
Topics: Abdomen; Animals; Behavior, Animal; Bumetanide; Capsaicin; Colon; Diuretics; Dose-Response Relationship, Drug; Heart; Hyperalgesia; Immunohistochemistry; Injections; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Perfusion; Physical Stimulation; Proto-Oncogene Proteins c-fos; Skin; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Cord | 2013 |
P2X₃ and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons.
Topics: Acrylamides; Anesthetics, Local; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Cells, Cultured; Hyperalgesia; Male; Masseter Muscle; Phosphorylation; Purinergic P2X Receptor Agonists; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Sensory Receptor Cells; Sensory System Agents; Skin; Touch; Trigeminal Ganglion; TRPV Cation Channels | 2013 |
Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.
Topics: A Kinase Anchor Proteins; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Capsaicin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Mice; Multiprotein Complexes; Nerve Tissue Proteins; Protein Kinase C; Sensory System Agents; TRPV Cation Channels | 2013 |
Contribution of sensory C-fiber neuron injury to mechanical dynamic allodynia in a murine model of postherpetic neuralgia.
Topics: Animals; Antigens, Surface; Calcitonin Gene-Related Peptide; Capsaicin; Escape Reaction; Female; Functional Laterality; Hyperalgesia; Lectins, C-Type; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Nerve Fibers, Unmyelinated; Neuralgia, Postherpetic; Neurofilament Proteins; Pain Threshold; Reaction Time; Sensory Receptor Cells | 2013 |
Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors.
Topics: Amino Acid Transport Systems, Acidic; Animals; Behavior, Animal; Capsaicin; Core Binding Factor Alpha 2 Subunit; Hyperalgesia; Ion Channels; Mechanoreceptors; Mice; Mice, Knockout; Nerve Endings; Neuralgia; Physical Stimulation; Skin; Tyrosine 3-Monooxygenase | 2013 |
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Acid; Hot Temperature; Hydrolyzable Tannins; Hyperalgesia; Male; Mice; Motor Activity; Phyllanthus; Phytotherapy | 2013 |
Specific functioning of Cav3.2 T-type calcium and TRPV1 channels under different types of STZ-diabetic neuropathy.
Topics: Animals; Calcium; Calcium Channels, T-Type; Capsaicin; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Ganglia, Spinal; Hyperalgesia; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Sensory System Agents; TRPV Cation Channels | 2013 |
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Fentanyl; Ganglia, Spinal; Humans; Hyperalgesia; Male; Membrane Potentials; Morphine; Mutagenesis, Site-Directed; Protein Binding; Rats; Receptors, Opioid, mu; Sensory Receptor Cells; Substance Withdrawal Syndrome; Tritium; TRPV Cation Channels | 2013 |
Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats.
Topics: Amino Acid Sequence; Animals; Capsaicin; Hot Temperature; Hyperalgesia; Male; Pain; Peptide Fragments; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Thrombin | 2002 |
Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization.
Topics: Acetates; Adult; Amines; Analgesics; Capsaicin; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Humans; Hyperalgesia; Male | 2002 |
Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Capsaicin; Colforsin; Dinoprostone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GTP-Binding Protein alpha Subunits, Gi-Go; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neurons, Afferent; Pain Measurement; Pertussis Toxin; Phosphorylation; Proline; Receptors, Drug; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 2002 |
Effects of peripheral nerve injury on functional spinal VR1 receptors.
Topics: Action Potentials; Animals; Capsaicin; Denervation; Dose-Response Relationship, Drug; Down-Regulation; Hyperalgesia; Ligation; Nerve Fibers; Nerve Fibers, Myelinated; Neuralgia; Neuronal Plasticity; Nociceptors; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Physical Stimulation; Posterior Horn Cells; Rats; Receptors, Drug | 2002 |
Heat hyperalgesia in humans: assessed by different stimulus temperature profiles.
Topics: Adult; Afferent Pathways; Body Temperature; Capsaicin; Female; Humans; Hyperalgesia; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain Measurement; Skin | 2002 |
A unique representation of heat allodynia in the human brain.
Topics: Adult; Afferent Pathways; Brain; Brain Mapping; Capsaicin; Cerebrovascular Circulation; Functional Laterality; Humans; Hyperalgesia; Inflammation; Male; Nerve Fibers; Nerve Fibers, Myelinated; Nociceptors; Pain Measurement; Pain Threshold; Skin; Tomography, Emission-Computed | 2002 |
Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteers.
Topics: Adult; Afferent Pathways; Analgesics, Opioid; Capsaicin; Female; Humans; Hyperalgesia; Hypesthesia; Male; Mechanoreceptors; Muscle, Skeletal; Myofascial Pain Syndromes; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain Measurement; Physical Stimulation | 2002 |
Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.
Topics: Animals; Behavior, Animal; Capsaicin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Dinoprostone; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hyperalgesia; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Phospholipids; Prostaglandins; Protein Kinase C; Receptor, Metabotropic Glutamate 5; Receptors, Drug; Receptors, Metabotropic Glutamate; Signal Transduction; Type C Phospholipases | 2002 |
Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Nerve Crush; Nerve Fibers, Unmyelinated; Neuralgia; Neurons, Afferent; Nociceptors; Oxidopamine; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Skin; Spinal Nerves; Sympathetic Fibers, Postganglionic | 2002 |
Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.
Topics: Acetylcholine; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Capsaicin; Colitis; Colon; Cyclophosphamide; Cystitis; Disease Models, Animal; Drug Administration Routes; Homozygote; Hyperalgesia; Male; Mice; Mice, Knockout; Mustard Plant; NAV1.8 Voltage-Gated Sodium Channel; Neuropeptides; Pain; Pain Measurement; Plant Extracts; Plant Oils; Sodium Channels; Stimulation, Chemical; Urinary Bladder; Viscera | 2002 |
Spinal neurons that possess the substance P receptor are required for the development of central sensitization.
Topics: Animals; Capsaicin; Cytotoxins; Hyperalgesia; Immunotoxins; Injections, Spinal; Male; N-Glycosyl Hydrolases; Neurons; Nociceptors; Pain Measurement; Physical Stimulation; Plant Proteins; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Stimulation, Chemical; Substance P | 2002 |
The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.
Topics: Algorithms; Animals; Anticonvulsants; Capsaicin; Carbamazepine; Dose-Response Relationship, Drug; Guinea Pigs; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptors, Drug; Sciatic Nerve | 2003 |
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosides; GTP-Binding Proteins; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels; Steroids; Tetraethylammonium | 2003 |
A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans.
Topics: Analysis of Variance; Bee Venoms; Capsaicin; Humans; Hyperalgesia; Injections, Intradermal; Melitten; Neurogenic Inflammation; Pain; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Time Factors | 2003 |
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
Topics: Animals; Arachidonic Acids; Brain; Calcium; Calcium Channel Blockers; Capsaicin; Cattle; Cell Line; Cell Membrane; Cytosol; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Hyperalgesia; Inhibitory Concentration 50; Ions; Lipids; Male; Mass Spectrometry; Models, Chemical; Polyunsaturated Alkamides; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug; Temperature; Time Factors; TRPV Cation Channels | 2003 |
Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain.
Topics: Analgesia; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Gene Expression; Hot Temperature; Hyperalgesia; Male; Mice; Nerve Fibers; Pain; Pain Measurement; Receptors, Drug; TRPV Cation Channels | 2003 |
Low-threshold heat receptor in chick sensory neurons is upregulated independently of nerve growth factor after nerve injury.
Topics: Animals; Capsaicin; Cells, Cultured; Chick Embryo; Chickens; Cobalt; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Nerve Growth Factor; Neurons; Neurons, Afferent; Patch-Clamp Techniques; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sciatic Nerve; Sodium Channels; Thermosensing; Time Factors; TRPV Cation Channels; Up-Regulation | 2003 |
Cannabinoid agonists attenuate capsaicin-induced responses in human skin.
Topics: Adult; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dronabinol; Female; Humans; Hyperalgesia; Male; Pain Measurement; Skin | 2003 |
State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.
Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Disease Models, Animal; Diterpenes; Freund's Adjuvant; Ganglia, Spinal; Hindlimb; Hyperalgesia; Inflammation; Ligation; Male; Neurons; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System Diseases; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Peripheral tackykinin and excitatory amino acid receptors mediate hyperalgesia induced by Phoneutria nigriventer venom.
Topics: Animals; Capsaicin; Edema; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hindlimb; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Spider Venoms | 2003 |
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.
Topics: Afferent Pathways; Animals; Capsaicin; Diabetic Neuropathies; Disease Models, Animal; Hot Temperature; Hyperalgesia; Injections, Intravenous; Mice; Nerve Fibers, Myelinated; Neurons, Afferent; Pain; Phenotype; Receptors, Drug; Streptozocin | 2003 |
SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia.
Topics: Animals; Capsaicin; Carrageenan; Dose-Response Relationship, Drug; Drug Administration Routes; Glutamates; Hyperalgesia; Inflammation; Lower Extremity; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Kainic Acid | 2003 |
Aftersensations in experimental and clinical hypersensitivity.
Topics: Adult; Aged; Aged, 80 and over; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Pain; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Physical Stimulation; Time Factors; Wounds and Injuries | 2003 |
A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Hyperalgesia; Ligation; Male; Meloxicam; Morphine; Pain; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazines; Thiazoles; Thymic Factor, Circulating; Time Factors | 2003 |
Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Conditioning, Operant; Dose-Response Relationship, Drug; Escape Reaction; Female; Hot Temperature; Hyperalgesia; Immunotoxins; Injections, Spinal; Morphine; Pain Measurement; Rats; Rats, Long-Evans; Reaction Time; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P | 2003 |
The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Hyperalgesia; Injections, Intradermal; Male; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide | 2003 |
Functional MRI of the rat lumbar spinal cord involving painful stimulation and the effect of peripheral joint mobilization.
Topics: Animals; Ankle Joint; Blood Gas Analysis; Blood Pressure; Capsaicin; Disease Models, Animal; Forelimb; Hyperalgesia; Injections, Intra-Articular; Injections, Subcutaneous; Lumbosacral Region; Magnetic Resonance Imaging; Pain; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Spinal Cord; Stimulation, Chemical | 2003 |
Capsaicin-induced hyperalgesia and mu-opioid-induced antihyperalgesia in male and female Fischer 344 rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Buprenorphine; Capsaicin; Clinical Trials as Topic; Cycloparaffins; Disease Models, Animal; Female; Humans; Hyperalgesia; Male; Morphine; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Tetrahydronaphthalenes | 2003 |
Spatial and temporal profiles of flare and hyperalgesia after intradermal capsaicin.
Topics: Capsaicin; Hot Temperature; Humans; Hyperalgesia; Infrared Rays; Injections, Intradermal; Laser-Doppler Flowmetry; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Skin Temperature; Thermography; Time Factors; Urticaria; Vasodilation | 2003 |
Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin.
Topics: Adult; Brain Mapping; Capsaicin; Cerebral Cortex; Evoked Potentials; Female; Functional Laterality; Hand; Humans; Hyperalgesia; Injections, Intradermal; Low-Level Light Therapy; Male; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Psychophysics; Reaction Time; Skin; Time Factors | 2003 |
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.
Topics: Analgesics; Animals; Cannabinoids; Capsaicin; Disease Models, Animal; Hyperalgesia; Injections, Intradermal; Male; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2 | 2004 |
Capsaicin treatment inhibits osteopenia and heat hyperalgesia induced by chronic constriction injury to the sciatic nerve in rats.
Topics: Animals; Bone Density; Bone Diseases, Metabolic; Capsaicin; Hot Temperature; Hyperalgesia; Male; Nerve Endings; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P | 2003 |
A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Cell Movement; Endocannabinoids; Hyperalgesia; Male; Nerve Growth Factor; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2003 |
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
Topics: Action Potentials; Analysis of Variance; Animals; Capsaicin; Electrophysiology; Evoked Potentials; Histamine; Hot Temperature; Hyperalgesia; Injections, Intradermal; Laminectomy; Macaca fascicularis; Physical Stimulation; Posterior Horn Cells; Pruritus; Reaction Time; Skin; Spinothalamic Tracts; Stimulation, Chemical; Thalamus; Time Factors | 2004 |
Two types of C nociceptors in human skin and their behavior in areas of capsaicin-induced secondary hyperalgesia.
Topics: Action Potentials; Adolescent; Adult; Capsaicin; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Pain Measurement; Reaction Time; Skin | 2004 |
Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2.
Topics: Administration, Rectal; Animals; Behavior, Animal; Capsaicin; Colon; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Oligopeptides; Pain; Pain Measurement; Peptides; Receptor, PAR-1; Receptor, PAR-2; Time Factors; Up-Regulation; Viscera | 2004 |
The analgesic effect induced by capsaicin is enhanced in inflammatory states.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Disease Models, Animal; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Receptors, Drug; Time Factors | 2004 |
Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors.
Topics: Animals; Blotting, Western; Calcium; Capsaicin; Hyperalgesia; Immunohistochemistry; Microscopy, Fluorescence; Nerve Growth Factors; Nociceptors; Rats; Receptors, Drug; Recombinant Proteins; Transfection; TRPV Cation Channels; Tumor Cells, Cultured | 2004 |
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Enzyme Activators; Enzyme Inhibitors; Humans; Hyperalgesia; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, Drug; RNA, Messenger; Spinal Cord; Substance P; Type C Phospholipases | 2004 |
Presynaptic inhibition and spinal pain processing in mice: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia.
Topics: Afferent Pathways; Animals; Capsaicin; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Presynaptic Terminals; Reaction Time; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Nerve Roots; Synaptic Transmission | 2004 |
"Nocifensor" system re-revisited. Focus on "Two types of C nociceptor in human skin and their behavior in areas of capaicin-induced secondary hyperalgesia".
Topics: Capsaicin; Humans; Hyperalgesia; Nerve Fibers, Unmyelinated; Nociceptors; Skin | 2004 |
Opioid receptor desensitization contributes to thermal hyperalgesia in infant rats.
Topics: Animals; Animals, Newborn; Capsaicin; Dose-Response Relationship, Drug; Female; Hyperalgesia; Morphine; Narcotic Antagonists; Pain Measurement; Pregnancy; Rats; Rats, Long-Evans; Receptors, Opioid; Touch | 2004 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interactions; Hyperalgesia; Injections, Intramuscular; Injections, Spinal; Male; Melatonin; Neural Inhibition; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Cord; Spinal Cord Injuries; Tetrahydronaphthalenes; Tryptamines | 2004 |
Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice.
Topics: Animals; Avian Sarcoma Viruses; Capsaicin; Cell Line, Transformed; Cell Line, Tumor; Chronic Disease; Endothelin Receptor Antagonists; Endothelins; Fibroblasts; Genetic Vectors; Hindlimb; Hyperalgesia; Inflammation; Male; Mice; Morphine; Neoplasm Regression, Spontaneous; Neoplasm Transplantation; Nociceptors; Oligopeptides; Pain Measurement; Peptides, Cyclic; Piperidines; Rats; Reaction Time; Receptors, Endothelin | 2004 |
Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin.
Topics: Aging; Animals; Animals, Newborn; Capsaicin; Hyperalgesia; Membrane Potentials; Organ Culture Techniques; Rats; Reflex; Spinal Cord; Spinal Nerve Roots | 2004 |
Comparison of hyperalgesia induced by capsaicin injection and controlled heat injury: effect on temporal summation.
Topics: Adult; Capsaicin; Electric Stimulation; Female; Hot Temperature; Humans; Hyperalgesia; Male; Physical Stimulation; Skin | 2004 |
Neural activation during experimental allodynia: a functional magnetic resonance imaging study.
Topics: Adult; Brain Mapping; Capsaicin; Cerebral Cortex; Female; Functional Laterality; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Neurons; Pain; Pain Measurement; Physical Stimulation | 2004 |
Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia.
Topics: Administration, Rectal; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Capsaicin; Colon; Feedback; Foot; Glutamic Acid; Hyperalgesia; Injections; Mice; Mice, Knockout; Pain Measurement; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptosomes | 2004 |
Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.
Topics: Analgesics; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Histamine; Histamine Antagonists; Hyperalgesia; Injections, Spinal; Nerve Growth Factor; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Time Factors; Up-Regulation | 2004 |
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.
Topics: Administration, Oral; Animals; Camphanes; Cannabidiol; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hyperalgesia; Inflammation; Italy; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Drug; Rimonabant; Time Factors | 2004 |
Inhibitory effect of capsaicin evoked trigeminal pain on warmth sensation and warmth evoked potentials.
Topics: Adult; Afferent Pathways; Brain; Capsaicin; Electroencephalography; Evoked Potentials, Somatosensory; Female; Functional Laterality; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Nociceptors; Pain; Reaction Time; Thermosensing; Trigeminal Nerve | 2005 |
Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia.
Topics: Animals; Capsaicin; Hyperalgesia; Male; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley | 2004 |
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
Topics: Androstadienes; Animals; Capsaicin; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Ion Channels; Male; Morpholines; Nerve Growth Factor; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Skin; TRPV Cation Channels; Wortmannin | 2004 |
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
Topics: Animals; Brain-Derived Neurotrophic Factor; Capsaicin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Male; N-Methylaspartate; Nerve Fibers, Unmyelinated; Organ Culture Techniques; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; src-Family Kinases; Stimulation, Chemical; Substance P | 2004 |
Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves.
Topics: Animals; Aspartic Acid; Benzoates; Capsaicin; Dental Pulp; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Imidazoles; Injections, Subcutaneous; Ligation; Lip; Male; Mandibular Nerve; Microdialysis; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Trigeminal Nuclei | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2005 |
In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons.
Topics: Animals; Behavior, Animal; Benzylamines; Blotting, Western; Brefeldin A; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Cell Membrane; Cytosol; Drug Interactions; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurons; Physical Stimulation; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Receptors, AMPA; Spinal Cord; Sulfonamides; Time Factors | 2004 |
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
Topics: Animals; Brain; Capsaicin; COS Cells; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hydrocarbons, Aromatic; Hyperalgesia; Male; Mice; Nitrogen; Pain; Pyrazoles; Pyridazines; Rats | 2005 |
Acid-induced pain and its modulation in humans.
Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Female; Forearm; Hot Temperature; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Hyperalgesia; Ibuprofen; Injections, Subcutaneous; Ion Channels; Iontophoresis; Male; Membrane Proteins; Middle Aged; Nerve Tissue Proteins; Pain; Pain Measurement; Pain Threshold; Refractory Period, Electrophysiological; Single-Blind Method; Sodium Channels; TRPV Cation Channels | 2004 |
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
Topics: Acrylamides; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Humans; Hyperalgesia; Inflammation; Motor Activity; Neurons; Pain Measurement; Patch-Clamp Techniques; Protons; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Transfection | 2005 |
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia.
Topics: Animals; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Enzyme Activation; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Ion Channels; Male; Mitogen-Activated Protein Kinase 6; Neurofilament Proteins; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; TRPV Cation Channels | 2005 |
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Topics: Animals; Arachidonic Acids; Calcium Signaling; Capsaicin; Cell Line; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Endocannabinoids; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; Inflammation Mediators; Ion Channel Gating; Ion Channels; Macrophage Inflammatory Proteins; Mice; Mice, Inbred BALB C; Neurons; Polyunsaturated Alkamides; Rats; Receptors, CCR1; Receptors, Chemokine; Transfection; TRPV Cation Channels | 2005 |
Vasomotor response to cold stimulation in human capsaicin-induced hyperalgesic area.
Topics: Adult; Analysis of Variance; Capsaicin; Cold Temperature; Female; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Pain Measurement; Skin; Skin Temperature; Time Factors; Vasoconstriction; Vasodilation | 2005 |
A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging.
Topics: Acute Disease; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Medulla Oblongata; Psychophysics; Reticular Formation | 2005 |
Selective ablation of nociceptive neurons for elimination of hyperalgesia and neurogenic inflammation.
Topics: Animals; Capsaicin; Diterpenes; Hyperalgesia; Immunohistochemistry; Macaca mulatta; Neurogenic Inflammation; Neurons, Afferent; Nociceptors; Trigeminal Ganglion | 2005 |
Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse.
Topics: Animals; Capsaicin; Cells, Cultured; Freund's Adjuvant; Glycoproteins; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Ion Channels; Men; Mice; Mice, Inbred C57BL; Nociceptors; TRPV Cation Channels | 2005 |
Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats.
Topics: Action Potentials; Alanine; Animals; Capsaicin; Drug Interactions; Edema; Extremities; GABA Plasma Membrane Transport Proteins; Hyperalgesia; Injections, Intradermal; Laminectomy; Male; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Fibers, Unmyelinated; Neural Conduction; Neural Inhibition; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Nerve Roots; Time Factors | 2005 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relationship, Drug; Edema; Formaldehyde; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Isoquinolines; Ligation; Male; Motor Activity; Osteoarthritis; Pain; Pain Measurement; Pain, Postoperative; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sciatic Nerve; Spinal Nerves; Urea | 2005 |
Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.
Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Carrageenan; Hindlimb; Hyperalgesia; Male; Models, Animal; Nociceptors; Pain; Rats; Rats, Wistar | 2005 |
Painful stimuli induce in vivo phosphorylation and membrane mobilization of mouse spinal cord NKCC1 co-transporter.
Topics: Animals; Blotting, Western; Capsaicin; Cell Membrane; Cytosol; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Neural Pathways; Pain; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Cord; Subcellular Fractions | 2005 |
Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse.
Topics: Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain Measurement; Physical Stimulation; Reaction Time; Receptors, Dopamine D2 | 2005 |
Heat and mechanical hyperalgesia in mice model of cancer pain.
Topics: Animals; Body Temperature; Capsaicin; Cell Count; Cell Line, Tumor; Cell Size; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Humans; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Pain; Pain Measurement; Pain Threshold; Reaction Time; Staining and Labeling; Time Factors; TRPV Cation Channels | 2005 |
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats.
Topics: Action Potentials; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Camphanes; Cannabinoids; Capsaicin; Cells, Cultured; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Neural Inhibition; Neurons; Pain Measurement; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord Diseases; Touch | 2005 |
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glycine; Hindlimb; Hyperalgesia; Indans; Male; Pain; Rats; Rats, Sprague-Dawley | 2005 |
Co-activation of P2Y2 receptor and TRPV channel by ATP: implications for ATP induced pain.
Topics: Adenosine Triphosphate; Animals; Calcium; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Hyperalgesia; Ion Channels; Mice; Neurons; Pain; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; TRPV Cation Channels | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area Under Curve; Blotting, Western; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Pain; Pain Measurement; Phosphorylation; Physical Stimulation; Protein Kinase C; Rats; Receptors, AMPA; Serine; Spider Venoms; Spinal Cord | 2005 |
TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Capsaicin; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Pain; Pain Measurement; TRPV Cation Channels | 2005 |
Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Enkephalins; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Hyperalgesia; Macaca; Morphine; Nociceptors; Reaction Time; Simplexvirus; Skin | 2006 |
Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Ganglia, Spinal; Heterozygote; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factor; Neuralgia; Neurofibromatosis 1; Neurons, Afferent; Neuropeptides; Organ Culture Techniques; Pain Threshold; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins p21(ras); Substance P; Synaptic Transmission | 2006 |
Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study.
Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Capsaicin; Chronic Disease; Complex Regional Pain Syndromes; Critical Period, Psychological; Disease Models, Animal; Foot; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Nerve Fibers, Unmyelinated; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Up-Regulation | 2005 |
Effects of cold stimulation on secondary hyperalgesia (HA) induced by capsaicin in healthy volunteers.
Topics: Adult; Capsaicin; Cold Temperature; Elbow; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Nerve Fibers, Myelinated; Pain Measurement; Photic Stimulation; Physical Stimulation; Pilot Projects; Wrist | 2006 |
Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin.
Topics: Animals; Capsaicin; Cells, Cultured; Enzyme Activation; Hyperalgesia; Male; Posterior Horn Cells; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Touch | 2006 |
Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons.
Topics: Animals; Capsaicin; Cells, Cultured; Cold Temperature; Dose-Response Relationship, Drug; Hyperalgesia; Menthol; Neurons, Afferent; Nociceptors; Pain Threshold; Posterior Horn Cells; Rats; Sensitivity and Specificity; Tissue Distribution; TRPM Cation Channels | 2006 |
Gender differences in pain and secondary hyperalgesia after heat/capsaicin sensitization in healthy volunteers.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Reference Values; Sex Factors | 2006 |
CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; DNA Primers; DNA, Complementary; Formaldehyde; Hyperalgesia; Ligation; Male; Mice; Microglia; Nervous System Physiological Phenomena; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sciatic Nerve; Spinal Cord; Spinal Nerves; Transcription, Genetic | 2006 |
Pivotal involvement of neurogenic mechanism in subcutaneous bee venom-induced inflammation and allodynia in unanesthetized conscious rats.
Topics: Analysis of Variance; Animals; Bee Venoms; Behavior, Animal; Capsaicin; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Rhizotomy; Sciatic Nerve; Touch; Wakefulness | 2006 |
Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin.
Topics: Animals; Bradykinin; Capsaicin; Colon; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Pain Measurement; Receptor, PAR-2; Time Factors; Trypsin | 2006 |
Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay.
Topics: Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Conditioning, Operant; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley | 2006 |
The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization.
Topics: Adult; Botulinum Toxins, Type A; Capsaicin; Face; Forehead; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Pressure; Regional Blood Flow; Skin Temperature; Trigeminal Nerve; Urticaria | 2006 |
Heat/burning sensation induced by topical application of capsaicin on perineal cutaneous area: new approach in diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome?
Topics: Administration, Topical; Adult; Analgesics, Non-Narcotic; Capsaicin; Chronic Disease; Feasibility Studies; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Unmyelinated; Nociceptors; Pain Measurement; Pelvic Pain; Perineum; Prostatitis; Treatment Outcome | 2006 |
Increased pain sensitivity to intraoral capsaicin in patients with atypical odontalgia.
Topics: Analysis of Variance; Capsaicin; Case-Control Studies; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Pain Threshold; Sensitivity and Specificity; Toothache; Trigeminal Nerve | 2006 |
Role of the Na+-K+-2Cl- cotransporter in the development of capsaicin-induced neurogenic inflammation.
Topics: Animals; Bumetanide; Capsaicin; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Rats; Rats, Sprague-Dawley; Reflex; Sodium-Potassium-Chloride Symporters; Vasodilation | 2006 |
Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.
Topics: Administration, Oral; Analgesics; Animals; Benzimidazoles; Biological Availability; Calcium; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Freund's Adjuvant; Hot Temperature; Hydrogen-Ion Concentration; Hyperalgesia; Male; Pain Measurement; Piperazines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; TRPV Cation Channels | 2006 |
Chronic nerve growth factor administration increases the peripheral exocytotic activity of capsaicin-sensitive cutaneous neurons.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Exocytosis; Hot Temperature; Hyperalgesia; In Vitro Techniques; Injections, Subcutaneous; Male; Nerve Endings; Nerve Growth Factor; Neurogenic Inflammation; Neurons; Rats; Rats, Sprague-Dawley; Skin | 2006 |
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior.
Topics: Animals; Behavior, Animal; Body Temperature; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Gastrointestinal Hormones; Gene Expression Regulation; Hyperalgesia; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; TRPV Cation Channels | 2006 |
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
Topics: Animals; Calcium Signaling; Capsaicin; Cell Line; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Ganglia, Spinal; Gene Expression Regulation, Enzymologic; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; TRPV Cation Channels | 2006 |
Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.
Topics: Analysis of Variance; Animals; Benzothiazoles; Brain; Capsaicin; Drug Synergism; Ganglia, Spinal; Histamine H2 Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Pain Measurement; Phenoxypropanolamines; Piperidines; Reaction Time; Receptors, Histamine H2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Touch | 2006 |
Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid | 2006 |
Capsaicin-evoked brain activation and central sensitization in anaesthetised rats: a functional magnetic resonance imaging study.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Capsaicin; Hyperalgesia; Injections, Intradermal; Magnetic Resonance Imaging; Mesencephalon; Ointments; Oxygen; Pain; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Superior Colliculi; Thalamus; Time Factors | 2006 |
Differential responses of rostral subnucleus caudalis and upper cervical dorsal horn neurons to mechanical and chemical stimulation of the parotid gland in rats.
Topics: Action Potentials; Afferent Pathways; Animals; Capsaicin; Cervical Vertebrae; Cold Temperature; Hyperalgesia; Inflammation Mediators; Male; Nociceptors; Pain; Pain Measurement; Pain Threshold; Parotid Gland; Parotitis; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Skin; Trigeminal Caudal Nucleus | 2006 |
Assessing mechanical sensitivity of masseter muscle in lightly anesthetized rats: a model for craniofacial muscle hyperalgesia.
Topics: Analgesics, Non-Narcotic; Anesthesia; Animals; Behavior; Bradykinin; Capsaicin; Facial Pain; Glutamic Acid; Humans; Hyperalgesia; Male; Masseter Muscle; Models, Biological; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2006 |
Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Cells, Cultured; Female; Gene Expression Regulation; Hyperalgesia; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Protein Kinases; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; RNA, Messenger; Second Messenger Systems; Serotonin; Serotonin Agents; Synapses; TRPV Cation Channels | 2006 |
Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo.
Topics: Animals; Capsaicin; Cells, Cultured; Drug Synergism; Ganglia, Spinal; Glial Cell Line-Derived Neurotrophic Factor; Growth Substances; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Multigene Family; Nerve Growth Factor; Nerve Tissue Proteins; Neurons, Afferent; Neurturin; Nociceptors; Receptors, Cell Surface; Skin; Time Factors; Tissue Distribution; TRPV Cation Channels | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.
Topics: Animals; Biphenyl Compounds; Blotting, Western; Capsaicin; Cells, Cultured; Dinoprostone; Electrophysiology; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Hybridization; Inflammation; Injections, Spinal; Male; Neurons; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Small Interfering | 2006 |
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Cultured; Central Nervous System; Disease Models, Animal; Humans; Hyperalgesia; Indazoles; Inflammation Mediators; Injections, Spinal; Male; Nociceptors; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Sulfones; Treatment Outcome; TRPV Cation Channels; Urea | 2006 |
Intradermal capsaicin causes dose-dependent pain, allodynia, and hyperalgesia in humans.
Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain | 2006 |
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Drug Interactions; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Time Factors; Vibration | 2007 |
The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.
Topics: Administration, Oral; Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabis; Capsaicin; Chronic Disease; Dinoprostone; Freund's Adjuvant; Hyperalgesia; Inflammation; Lipid Peroxides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Sciatic Neuropathy; Tumor Necrosis Factor-alpha | 2007 |
Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; Avoidance Learning; Capsaicin; Carbolines; Catheterization; Colon; Electromyography; Gastrointestinal Agents; Hyperalgesia; Irritable Bowel Syndrome; Male; Nociceptors; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Rectum; Stress, Psychological; Vagotomy; Vagus Nerve; Visceral Afferents | 2007 |
The role of uninjured C-afferents and injured afferents in the generation of mechanical hypersensitivity after partial peripheral nerve injury in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Ganglia, Spinal; Hyperalgesia; Ligation; Lumbosacral Region; Male; Nerve Fibers, Unmyelinated; Nervous System Diseases; Neural Conduction; Neurons, Afferent; Nociceptors; Rats; Rats, Sprague-Dawley; Rhizotomy; Sciatic Nerve; Spinal Nerves; Time Factors | 2007 |
Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: a systematic comparative study in conscious rats.
Topics: Analgesics, Non-Narcotic; Animals; Bee Venoms; Behavior, Animal; Capsaicin; Carrageenan; Edema; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Irritants; Male; Neuralgia; Neuritis; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time | 2007 |
Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Inflammation; Injections, Intraventricular; Injections, Subcutaneous; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid; Sex Factors | 2007 |
Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity.
Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Cold Temperature; Enzyme Activation; Hot Temperature; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Male; Mitogen-Activated Protein Kinase 6; Neurons, Afferent; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; RNA, Antisense; Signal Transduction; TRPV Cation Channels | 2007 |
The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
Topics: Acetic Acid; Age Factors; Anilides; Animals; Animals, Newborn; Capsaicin; Catheterization; Cinnamates; Colon; Disease Models, Animal; Diterpenes; Electromyography; Ganglia, Spinal; Hyperalgesia; Irritable Bowel Syndrome; Male; Pain; Rats; Rats, Sprague-Dawley; Reflex, Abdominal; TRPV Cation Channels; Visceral Afferents | 2007 |
Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain.
Topics: Animals; Capsaicin; Disease Models, Animal; Hyperalgesia; Male; Pain; Pain Threshold; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate | 2007 |
The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Antioxidants; Behavior, Animal; Capsaicin; Cyclic N-Oxides; Disease Models, Animal; Drug Interactions; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spin Labels; Time Factors | 2007 |
Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study.
Topics: Administration, Topical; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Individuality; Logistic Models; Magnetic Resonance Imaging; Male; Neural Pathways; Nociceptors; Pain Measurement; Physical Stimulation; Positron-Emission Tomography; Psychophysics; Synaptic Transmission; Trigeminal Nerve | 2007 |
Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked pain.
Topics: Adult; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Humans; Hyperalgesia; Inflammation Mediators; Laser-Doppler Flowmetry; Male; Middle Aged; Models, Neurological; Nerve Fibers, Unmyelinated; Neuronal Plasticity; Neurosecretory Systems; Nociceptors; Pain; Pain Measurement; Psychophysics; Regional Blood Flow; Sensory Receptor Cells; Skin; Time Factors | 2007 |
A role for peripheral afferents in the pathophysiology and treatment of at-level neuropathic pain in spinal cord injury? A case report.
Topics: Administration, Topical; Afferent Pathways; Capsaicin; Humans; Hyperalgesia; Lidocaine; Male; Middle Aged; Spinal Fractures; Thoracic Vertebrae | 2007 |
The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level.
Topics: Analgesics; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Hyperalgesia; Injections, Spinal; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spinal Cord; TRPV Cation Channels | 2008 |
Static magnetic field-induced anti-nociceptive effect and the involvement of capsaicin-sensitive sensory nerves in this mechanism.
Topics: Analgesia; Animals; Capsaicin; Carrageenan; Chemoreceptor Cells; Diterpenes; Electromagnetic Fields; Formaldehyde; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Nerve Fibers; Neurons, Afferent; Pain Measurement; Postural Balance | 2007 |
Painful nerve injury shortens the intracellular Ca2+ signal in axotomized sensory neurons of rats.
Topics: Animals; Axotomy; Calcium Signaling; Capsaicin; Cell Size; Cytophotometry; Electric Stimulation; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Nerve Fibers; Neurons, Afferent; Nociceptors; Peripheral Nerve Injuries; Potassium; Rats; Rats, Sprague-Dawley; Spinal Nerves; Stimulation, Chemical; Wallerian Degeneration | 2007 |
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
Topics: Animals; Aprotinin; Calcium Signaling; Capsaicin; Edema; Enteropeptidase; Ganglia, Spinal; Granulocytes; Humans; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptor, PAR-2; Receptors, Proteinase-Activated; Receptors, Thrombin; Recombinant Proteins; Trypsin; Trypsin Inhibitors | 2007 |
Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior.
Topics: Animals; Behavior, Animal; Capsaicin; Colitis; Colon; Dextran Sulfate; Female; Hyperalgesia; Mice; Mice, Inbred C57BL; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Spinal Cord; TRPV Cation Channels | 2007 |
Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis.
Topics: Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; Hyperalgesia; Male; Membrane Potentials; Pain Measurement; Pain Threshold; Pancreas; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Up-Regulation | 2007 |
The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis.
Topics: Animals; Capsaicin; Colitis; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Electromyography; Ganglia, Spinal; Gastrointestinal Motility; Hyperalgesia; Male; Neurons; Rats; Rats, Sprague-Dawley; Reflex, Abdominal; Sulfonamides; Thiourea; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Visceral Afferents | 2007 |
Depletion of capsaicin-sensitive afferents prevents lamina-dependent increases in spinal N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats.
Topics: Afferent Pathways; Animals; Capsaicin; Diterpenes; Hot Temperature; Hyperalgesia; Ligation; Male; Perception; Phosphorylation; Posterior Horn Cells; Pressure; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy; Spinal Cord; Time Factors; TRPV Cation Channels; Up-Regulation | 2008 |
Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity.
Topics: Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hyperalgesia; Male; Masseter Muscle; Methylene Blue; Mice; Nerve Tissue Proteins; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sensory Thresholds; Soluble Guanylyl Cyclase; Time Factors; Trigeminal Caudal Nucleus | 2007 |
Nociceptive tuning by stem cell factor/c-Kit signaling.
Topics: Animals; Calcium; Capsaicin; Cell Count; Electrophysiology; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Mechanoreceptors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron; Mutation; Neurons, Afferent; Nociceptors; Pain Measurement; Patch-Clamp Techniques; Proto-Oncogene Proteins c-kit; Signal Transduction; Skin; Stem Cell Factor; TRPV Cation Channels | 2007 |
TRPM8 mechanism of cold allodynia after chronic nerve injury.
Topics: Animals; Capsaicin; Cells, Cultured; Chronic Disease; Cold Temperature; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Menthol; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Skin; TRPM Cation Channels | 2007 |
The role of capsaicin-sensitive primary afferents in experimental sciatica induced by disc herniation in rats.
Topics: Administration, Topical; Animals; Capsaicin; Cell Count; Disease Models, Animal; Hot Temperature; Hyperalgesia; Immunoenzyme Techniques; Intervertebral Disc Displacement; Nerve Compression Syndromes; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sciatica; Sensory System Agents; Spinal Cord | 2008 |
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia.
Topics: Administration, Cutaneous; Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Edema; Electric Stimulation; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurogenic Inflammation; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Sciatic Nerve; Time Factors; TRPV Cation Channels | 2008 |
Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Catechols; Disease Models, Animal; Diterpenes; Drug Interactions; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nerve Fibers, Unmyelinated; Nerve Regeneration; Neural Conduction; Neuroprotective Agents; Peripheral Nervous System Diseases; Reaction Time; Skin; Substance P; Ubiquitin Thiolesterase | 2008 |
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain.
Topics: Acute Disease; Analgesics, Opioid; Animals; Capsaicin; Data Interpretation, Statistical; Dextromethorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hot Temperature; Hyperalgesia; Male; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Inbred F344; Sex Characteristics | 2008 |
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Topics: Acids; Animals; Capsaicin; Hyperalgesia; Inflammation; Mole Rats; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells | 2008 |
Local application of capsaicin alleviates mechanical hyperalgesia after spinal nerve transection.
Topics: Analgesics; Animals; Biomarkers; Calcitonin Gene-Related Peptide; Capsaicin; Cell Count; Denervation; Ganglia, Spinal; Hyperalgesia; Male; Nerve Degeneration; Neuralgia; Neurons, Afferent; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels | 2008 |
Leukemia inhibitory factor differentially regulates capsaicin and heat sensitivity in cultured rat dorsal root ganglion neurons.
Topics: Animals; Capsaicin; Cells, Cultured; Galanin; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Leukemia Inhibitory Factor; Male; Nerve Growth Factor; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels | 2008 |
Dissociable neural activity to self- vs. externally administered thermal hyperalgesia: a parametric fMRI study.
Topics: Adaptation, Psychological; Adult; Brain; Brain Mapping; Capsaicin; Cerebral Cortex; Chronic Disease; Cognition; Data Interpretation, Statistical; Functional Laterality; Gyrus Cinguli; Hot Temperature; Humans; Hyperalgesia; Limbic System; Magnetic Resonance Imaging; Male; Neurons; Neuropsychological Tests; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Self Administration; Somatosensory Cortex | 2008 |
Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice.
Topics: Animals; Capsaicin; Free Radical Scavengers; Hyperalgesia; Male; Mice; Oxidative Stress; Pain Measurement; Physical Stimulation; Spinal Cord; Touch | 2008 |
NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin.
Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Lidocaine; Male; Medulla Oblongata; Microinjections; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pilot Projects; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1 | 2008 |
Fire in the hole: pore dilation of the capsaicin receptor TRPV1.
Topics: Animals; Capsaicin; Cell Membrane Permeability; Humans; Hyperalgesia; Inflammation Mediators; Ion Channel Gating; Ions; Models, Molecular; Neurogenic Inflammation; Nociceptors; Pain; Sensory Receptor Cells; Sensory System Agents; Signal Transduction; TRPV Cation Channels | 2008 |
Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Foot Diseases; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Neoplasms, Experimental; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Inbred F344; Ruthenium Red; TRPV Cation Channels | 2008 |
Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model.
Topics: Animals; Capsaicin; Carcinoma; Cells, Cultured; Etanercept; Gene Deletion; Hindlimb; Hot Temperature; Hyperalgesia; Immunoglobulin G; Mice; Neoplasm Transplantation; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia.
Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Cell Line; Electrophysiology; Endothelin-1; Hot Temperature; Humans; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Reaction Time; Receptor, Endothelin A; TRPV Cation Channels | 2008 |
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision.
Topics: Acrylamides; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Male; Morphine; Pain, Postoperative; Physical Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels | 2008 |
Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin.
Topics: Adolescent; Adult; Capsaicin; Drug Eruptions; Female; Hot Temperature; Humans; Hyperalgesia; Male; Norepinephrine; Pain Threshold; Regional Blood Flow; Skin; Sympathetic Nervous System; Vasomotor System | 1995 |
Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat.
Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Male; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley; Sympathetic Fibers, Postganglionic | 1995 |
Sensitization of insensitive branches of C nociceptors in human skin.
Topics: Adult; Capsaicin; Electric Stimulation; Electrophysiology; Humans; Hyperalgesia; Inflammation; Male; Mechanoreceptors; Mustard Plant; Nociceptors; Plant Extracts; Plant Oils; Skin | 1994 |
Inflammation and hyperalgesia in rats neonatally treated with capsaicin: effects on two classes of nociceptive neurons in the superficial dorsal horn.
Topics: Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Electric Stimulation; Female; Freund's Adjuvant; Hyperalgesia; Immunohistochemistry; Inflammation; Microscopy, Electron; Nerve Fibers; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Different patterns of hyperalgesia induced by experimental inflammation in human skin.
Topics: Adult; Capsaicin; Dermatitis; Female; Freezing; Humans; Hyperalgesia; Male; Middle Aged; Pain; Physical Stimulation; Sensation; Sensory Thresholds; Skin | 1994 |
Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation.
Topics: Amino Acid Sequence; Animals; Capsaicin; Depression, Chemical; Electric Stimulation; Foot; Hyperalgesia; Male; Molecular Sequence Data; Naloxone; Narcotics; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Skin; Ultraviolet Rays | 1994 |
The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat.
Topics: Animals; Arthritis, Experimental; Capsaicin; Disease Models, Animal; Enflurane; Female; Freund's Adjuvant; Hyperalgesia; Rats; Rats, Sprague-Dawley; Uric Acid | 1993 |
Topical capsaicin in treatment of hyperalgesia, allodynia and dysesthetic pain caused by malignant tumour infiltration of the skin.
Topics: Administration, Topical; Adult; Capsaicin; Humans; Hyperalgesia; Male; Pain; Skin Neoplasms | 1993 |
Dissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy.
Topics: Adult; Capsaicin; Evoked Potentials; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Male; Mechanoreceptors; Nerve Fibers; Neurons, Afferent; Nociceptors; Peripheral Nervous System Diseases | 1993 |
Facilitation of the human nociceptive reflex by stimulation of A beta-fibres in a secondary hyperalgesic area sustained by nociceptive input from the primary hyperalgesic area.
Topics: Adrenergic Fibers; Adult; Analysis of Variance; Capsaicin; Foot; Humans; Hyperalgesia; Pain Measurement; Pain Threshold; Reflex | 1995 |
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.
Topics: Adenosine; Animals; Capsaicin; Cells, Cultured; Dinoprostone; Ganglia, Spinal; Hyperalgesia; Kinetics; Male; Membrane Potentials; Neurons; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Serotonin; Sodium Channels; Tetrodotoxin; Thromboxane B2 | 1996 |
Cutaneous pretreatment with the capsaicin analog NE-21610 prevents the pain to a burn and subsequent hyperalgesia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Burns; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Pain; Pain Measurement; Physical Stimulation; Skin | 1995 |
Brief, prolonged and repeated stimuli applied to hyperalgesic skin areas: a psychophysical study.
Topics: Capsaicin; Electric Stimulation; Hot Temperature; Humans; Hyperalgesia; Lasers; Pain; Pain Threshold; Psychophysics; Skin | 1996 |
Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism.
Topics: Adult; Capsaicin; Humans; Hyperalgesia; Middle Aged; Nerve Block; Nerve Fibers; Pain; Spinal Cord | 1996 |
Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors.
Topics: Animals; Capsaicin; Female; Hyperalgesia; Knee Joint; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Substance P | 1996 |
Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Foot; Hot Temperature; Hyperalgesia; Injections; Male; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex | 1996 |
Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Capsaicin; Hyperalgesia; Injections, Intradermal; Male; Microdialysis; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Pain; Pain Threshold; Peptides; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spider Venoms | 1997 |
Capsaicin-evoked mechanical allodynia and hyperalgesia cross-nerve territories.
Topics: Capsaicin; Humans; Hyperalgesia; Pain; Pharmaceutical Vehicles | 1997 |
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Topics: Animals; Capsaicin; Cell Membrane; Cells, Cultured; Fluorescent Antibody Technique; Hyperalgesia; Immunotoxins; Injections, Spinal; N-Glycosyl Hydrolases; Neurons; Pain; Pain Management; Pain Measurement; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P | 1997 |
Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex.
Topics: Animals; Capsaicin; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Ganglia, Spinal; Hindlimb; Hot Temperature; Hyperalgesia; Immersion; Male; Mechanoreceptors; Nerve Fibers; Nerve Regeneration; Neuralgia; Neurites; Neurons, Afferent; Nociceptors; Physical Stimulation; Plasma; Rats; Rats, Wistar; Reflex; Sciatic Nerve | 1997 |
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Capsaicin; Electric Stimulation; Endocytosis; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Long-Term Potentiation; Male; Microscopy, Confocal; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1997 |
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Hypesthesia; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Nerve Growth Factors; Neurotrophin 3; Organophosphorus Compounds; Pain; Pain Threshold; Perfusion; Pressure; Rats; Rats, Wistar; Secretory Rate; Single-Blind Method; Spinal Cord; Substance P | 1997 |
Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist.
Topics: Analgesics, Non-Narcotic; Animals; Brain; Capsaicin; Carrageenan; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Subcutaneous; Male; Motor Activity; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetradecanoylphorbol Acetate | 1997 |
Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Animals; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hyperalgesia; Injections, Intradermal; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord | 1997 |
Postnatal NGF administration causes adult hyperalgesia and overreactivity to social stimuli but does not reverse capsaicin induced hypoalgesia.
Topics: Aggression; Animals; Animals, Newborn; Capsaicin; Female; Hot Temperature; Hyperalgesia; Male; Mice; Nerve Growth Factors; Pain Measurement; Social Behavior | 1997 |
Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans.
Topics: Adolescent; Adult; Capsaicin; Conditioning, Psychological; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Nociceptors; Pain Threshold; Perception; Synapses; Touch | 1998 |
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Carrageenan; Edema; Endocannabinoids; Hindlimb; Hyperalgesia; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Skin | 1998 |
Nitric oxide contributes to central sensitization following intradermal injection of capsaicin.
Topics: Analysis of Variance; Animals; Capsaicin; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Spinal Cord | 1998 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord | 1998 |
The effect of noradrenaline, angiotensin II and vasopressin on blood flow and sensitivity to heat in capsaicin-treated skin.
Topics: Adolescent; Adult; Angiotensin II; Capsaicin; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Norepinephrine; Regional Blood Flow; Skin; Vasoconstrictor Agents; Vasopressins | 1998 |
Enhancement of thermal hyperalgesia by alpha-adrenoceptors in capsaicin-treated skin.
Topics: Administration, Topical; Adolescent; Adrenergic alpha-Antagonists; Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Norepinephrine; Pain Threshold; Phenoxybenzamine; Receptors, Adrenergic, alpha; Skin; Sympathomimetics; Tyramine | 1998 |
Effects of endothelin-1 on capsaicin-induced nociception in mice.
Topics: Analgesia; Animals; Bosentan; Capsaicin; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hindlimb; Hyperalgesia; Male; Mice; Oligopeptides; Peptide Fragments; Peptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Serotonin; Sulfonamides; Viper Venoms | 1998 |
Increased capsaicin-induced secondary hyperalgesia as a marker of abnormal sensory activity in patients with fibromyalgia.
Topics: Biomarkers; Capsaicin; Female; Fibromyalgia; Ganglia, Sensory; Humans; Hyperalgesia; Male; Middle Aged | 1998 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Substance P; Zymosan | 1998 |
Differential effect of painful heterotopic stimulation on capsaicin-induced pain and allodynia.
Topics: Adult; Capsaicin; Cold Temperature; Differential Threshold; Humans; Hyperalgesia; Injections, Subcutaneous; Male; Models, Neurological; Pain; Pain Measurement; Physical Stimulation; Spinal Cord; Time Factors | 1998 |
Transient inhibition of responses to thermal stimuli of spinal sensory tract neurons in monkeys during sensitization by intradermal capsaicin.
Topics: Animals; Capsaicin; Female; Hot Temperature; Hyperalgesia; Injections, Intradermal; Macaca fascicularis; Male; Neurons, Afferent; Physical Stimulation; Spinothalamic Tracts | 1998 |
Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclooxygenase Inhibitors; Freund's Adjuvant; Hyperalgesia; Ibuprofen; In Vitro Techniques; Injections, Spinal; Ketorolac; Male; Myelitis; Neuropeptides; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tolmetin | 1998 |
Region-specific increase in glutamate release from dorsal horn of rats with adjuvant inflammation.
Topics: Animals; Capsaicin; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Mycobacterium; Myelitis; Nociceptors; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord | 1998 |
Involvement of capsaicin sensitive primary afferents in thymulin-induced hyperalgesia.
Topics: Animals; Capsaicin; Hyperalgesia; Injections, Intraperitoneal; Interleukin-1; Nerve Growth Factors; Neurons, Afferent; Pain Threshold; Rats; Rats, Sprague-Dawley; Thymic Factor, Circulating; Vagotomy; Vagus Nerve | 1998 |
Lipopolysaccharide-induced hyperalgesia of intracranial capsaicin sensitive afferents in conscious rats.
Topics: Animals; Behavior, Animal; Brain; Capsaicin; Cerebral Ventricles; Escape Reaction; Exploratory Behavior; Grooming; Hyperalgesia; Injections, Intraventricular; Lipopolysaccharides; Male; Neurons, Afferent; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Solitary Nucleus; Trigeminal Caudal Nucleus | 1998 |
A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance.
Topics: Animals; Capsaicin; Carrageenan; Functional Laterality; Hindlimb; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; Spinal Cord | 1998 |
The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Capsaicin; Carrageenan; Dinoprostone; Dose-Response Relationship, Drug; Excipients; Hindlimb; Hyperalgesia; Inflammation; Inflammation Mediators; Male; Nociceptors; Oxytocics; Pain; Pain Threshold; Rats; Rats, Wistar; Thionucleotides; Ultraviolet Rays | 1999 |
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.
Topics: Animals; Capsaicin; Diterpenes; Hyperalgesia; Ligation; Male; Neurons, Afferent; Pain; Pain Measurement; Peripheral Nervous System; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Time Factors | 1999 |
Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons.
Topics: Animals; Capsaicin; Enzyme Inhibitors; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis; Male; Microdialysis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Spinal Cord; Spinothalamic Tracts | 1999 |
Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation.
Topics: Adult; Body Temperature; Capsaicin; Female; Humans; Hyperalgesia; Male; Pain; Regional Blood Flow; Skin; Sympathetic Nervous System; Vasodilation | 1999 |
The cannabinoid receptor agonist WIN 55,212-2 mesylate blocks the development of hyperalgesia produced by capsaicin in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Capsaicin; Hot Temperature; Hyperalgesia; Male; Morpholines; Motor Activity; Naphthalenes; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 1999 |
Neurokinin-1 receptors are involved in behavioral responses to high-intensity heat stimuli and capsaicin-induced hyperalgesia in mice.
Topics: Animals; Capsaicin; Hot Temperature; Hyperalgesia; Mice; Mice, Inbred BALB C; Mice, Knockout; Pain; Reaction Time; Receptors, Neurokinin-1 | 1999 |
Role of intracellular calcium in thermal allodynia and hyperalgesia in diabetic mice.
Topics: Animals; Calcium; Capsaicin; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain Threshold; Reaction Time; Reflex; Ryanodine; Spinal Cord; Thapsigargin | 1999 |
Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice.
Topics: Analysis of Variance; Animals; Capsaicin; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred ICR; Naphthalenes; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Spinal Cord | 1999 |
Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study.
Topics: Adult; Brain; Capsaicin; Female; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Pain; Pain Measurement | 1999 |
Tourniquet constriction exacerbates hyperalgesia-related pain induced by intradermal capsaicin injection.
Topics: Administration, Cutaneous; Adult; Capillaries; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Regional Blood Flow; Skin; Tourniquets | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Postural Balance | 1999 |
Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?
Topics: Animals; Capsaicin; Disease Models, Animal; Functional Laterality; Hot Temperature; Hyperalgesia; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatica | 1999 |
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Carrageenan; Dinoprostone; Dipeptides; Dose-Response Relationship, Drug; Edema; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Pain; Rats; Rats, Wistar; Receptor, Bradykinin B2; Time Factors | 1999 |
Secondary hyperalgesia to punctate mechanical stimuli. Central sensitization to A-fibre nociceptor input.
Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Nerve Block; Neural Conduction; Nociceptors; Pain Measurement; Radial Nerve; Touch | 1999 |
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Pain Measurement; Sesquiterpenes | 2000 |
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Local; Animals; Azocines; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Fentanyl; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
No effect of sympathetic sudomotor activity on capsaicin-evoked ongoing pain and hyperalgesia.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Physical Stimulation; Skin; Skin Temperature; Sweat Glands; Sympathetic Nervous System | 2000 |
Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres.
Topics: Adult; Capsaicin; Electric Stimulation; Electrophysiology; Female; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Pain; Reaction Time; Skin; Stimulation, Chemical | 2000 |
Endothelin-1-induced ET(A) receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ET(B) receptor activation.
Topics: Animals; Atrasentan; Capsaicin; Edema; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hyperalgesia; Male; Mice; Nociceptors; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Viper Venoms | 2000 |
The effect of peripheral opioid block and body cooling on sensitivity to heat in capsaicin-treated skin.
Topics: Adolescent; Adult; Capsaicin; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Naloxone; Receptors, Opioid | 2000 |
A new animal model for assessing mechanisms and management of muscle hyperalgesia.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Hand Strength; Hyperalgesia; Male; Muscle, Skeletal; Muscular Diseases; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley | 2000 |
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Carrageenan; Cells, Cultured; Electrophysiology; Endocannabinoids; Female; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Targeting; Hot Temperature; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Pain; Polyunsaturated Alkamides; Receptors, Drug; Stem Cells; TRPV Cation Channels | 2000 |
ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia.
Topics: Adenosine Triphosphate; Adult; Capsaicin; Drug Synergism; Female; Humans; Hyperalgesia; Iontophoresis; Male; Neurons, Afferent; Nociceptors; Pain; Regional Blood Flow; Skin; Touch; Ultraviolet Rays | 2000 |
Repetitive intradermal capsaicin: differential effect on pain and areas of allodynia and punctate hyperalgesia.
Topics: Adult; Afferent Pathways; Capsaicin; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Nociceptors; Pain Measurement; Pain Threshold; Spinal Cord; Synaptic Transmission | 2000 |
Prostaglandin E(2)-mediated sensitization of rat sensory neurons is not altered by nerve growth factor.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cyclic AMP; Dinoprostone; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Nerve Growth Factor; Neurons, Afferent; Nociceptors; Rats; Rats, Sprague-Dawley | 2000 |
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Physical Stimulation; Plant Extracts; Plant Oils; Receptors, Neurokinin-1; Substance P; Urinary Bladder; Visceral Afferents | 2000 |
Activation of the somatosensory cortex during Abeta-fiber mediated hyperalgesia. A MSI study.
Topics: Adult; Afferent Pathways; Capsaicin; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Forearm; Humans; Hyperalgesia; Magnetics; Male; Nerve Fibers; Neurons; Somatosensory Cortex | 2000 |
Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Cell Separation; Drug Resistance; Foot; Hyperalgesia; Injections, Subcutaneous; Male; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Phenotype; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Signal Transduction; Skin | 2000 |
Capsaicin and nociception: from basic mechanisms to novel drugs.
Topics: Capsaicin; Hot Temperature; Humans; Hyperalgesia; Models, Biological; Nociceptors; Receptors, Drug; TRPV Cation Channels | 2000 |
Effect of mexiletine on thermal allodynia and hyperalgesia in diabetic mice.
Topics: Analgesics; Animals; Capsaicin; Diabetes Complications; Drug Interactions; Hot Temperature; Hyperalgesia; Male; Mexiletine; Mice; Mice, Inbred ICR; Pain Measurement | 2000 |
Antinociceptive activity of ricinoleic acid, a capsaicin-like compound devoid of pungent properties.
Topics: Administration, Topical; Animals; Capsaicin; Carrageenan; Conjunctiva; Guinea Pigs; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Ricinoleic Acids | 2000 |
In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue.
Topics: Analgesics; Animals; Behavior, Animal; Blinking; Blood Pressure; Bronchoconstriction; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Eye; Female; Ganglia, Spinal; Guinea Pigs; Hindlimb; Hyperalgesia; Irritants; Male; Mice; Mice, Inbred Strains; Nociceptors; Nose; Odorants; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Turpentine; Urea | 2000 |
A novel transverse push-pull microprobe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Animals; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Male; Microdialysis; Nitrophenols; Physical Stimulation; Posterior Horn Cells; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Spinal Cord; Theophylline | 2001 |
The capsaicin analogue SDZ249-665 attenuates the hyper-reflexia and referred hyperalgesia associated with inflammation of the rat urinary bladder.
Topics: Algorithms; Analgesics; Animals; Capsaicin; Cystitis; Dose-Response Relationship, Drug; Hyperalgesia; Male; Rats; Rats, Wistar; Reflex; Time Factors; Turpentine; Urea; Urination | 2001 |
Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice.
Topics: Animals; Capsaicin; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Reaction Time; Receptors, Neurokinin-1 | 2001 |
The role of spinal cholecystokinin B receptors in thermal allodynia and hyperalgesia in diabetic mice.
Topics: Animals; Capsaicin; Cholecystokinin; Diabetes Mellitus, Experimental; Enzyme Activators; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Male; Meglumine; Mice; Mice, Inbred ICR; Nerve Fibers; Nociceptors; Pain; Protein Kinase C; Reaction Time; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Spinal Cord | 2001 |
Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Freund's Adjuvant; Hyperalgesia; Ketorolac; Macaca mulatta; Male; Morphine; Pain; Pain Measurement; Piperazines; Receptors, Opioid, delta | 2001 |
Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity.
Topics: Afferent Pathways; Animals; Axonal Transport; Capsaicin; Colchicine; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Nerve Endings; Oligodeoxyribonucleotides, Antisense; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Nerve; Transcription, Genetic | 2001 |
Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection.
Topics: Administration, Topical; Animals; Bee Venoms; Capsaicin; Hot Temperature; Hyperalgesia; Male; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2001 |
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia.
Topics: Adenosine Triphosphate; Capsaicin; Cells, Cultured; Drug Synergism; Humans; Hyperalgesia; Pain; Protein Kinase C; Receptors, Drug; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate | 2001 |
A new model of visceral pain and referred hyperalgesia in the mouse.
Topics: Abdomen; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Extravasation of Diagnostic and Therapeutic Materials; Female; Hindlimb; Hyperalgesia; Male; Mice; Morphine; Mustard Plant; Pain; Plant Extracts; Plant Oils; Touch | 2001 |
Knee joint mobilization reduces secondary mechanical hyperalgesia induced by capsaicin injection into the ankle joint.
Topics: Animals; Ankle Joint; Arthritis; Capsaicin; Disease Models, Animal; Hyperalgesia; Injections, Intra-Articular; Knee Joint; Male; Movement; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley | 2001 |
Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Calcium; Capsaicin; Cells, Cultured; Chemokines; Fluorescent Dyes; Ganglia, Spinal; HIV Envelope Protein gp120; Hyperalgesia; Inflammation; Intracellular Fluid; Male; Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, CCR4; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Substance P | 2001 |
Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Capsaicin; Hyperalgesia; Male; Morpholines; Naphthalenes; Neurons, Afferent; Pain Measurement; Peripheral Nerves; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
Influence of capsaicin cream in rats with peripheral neuropathy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Benzamides; Capsaicin; Carrageenan; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Isoindoles; Male; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Piperidines; Postoperative Period; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance Withdrawal Syndrome; Time Factors | 2001 |
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Myelinated; Nociceptors; Pain; Radial Nerve; Somatosensory Disorders | 2001 |
Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons.
Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Binding Sites; Capsaicin; Drosophila Proteins; Fluorescent Antibody Technique; Ganglia, Spinal; Hyperalgesia; Lectins; Microscopy, Confocal; Pain Measurement; Pain Threshold; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Drug; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Skin; Substance P | 2001 |
Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Male; Mecamylamine; Morphine; Narcotics; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2001 |
Pain increases during sympathetic arousal in patients with complex regional pain syndrome.
Topics: Adolescent; Adult; Arousal; Capsaicin; Cold Temperature; Complex Regional Pain Syndromes; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Norepinephrine; Reflex, Startle; Sympathetic Nervous System | 2001 |
Non-noxious A fiber afferent input enhances capsaicin-induced mechanical hyperalgesia in the rat.
Topics: Animals; Behavior, Animal; Capsaicin; Electric Stimulation; Hyperalgesia; Male; Nerve Fibers, Myelinated; Neuralgia; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2001 |
Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons.
Topics: Animals; Capsaicin; Cell Count; Cell Size; Fluorescent Antibody Technique; Fluorescent Dyes; Ganglia, Spinal; Hyperalgesia; Nerve Fibers; Nerve Fibers, Myelinated; Neurofilament Proteins; Neurons, Afferent; Nociceptors; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Drug; Synaptic Transmission; TRPV Cation Channels | 2001 |
Vasodilatation in hyperalgesic rat skin evoked by stimulation of afferent A beta-fibers: further evidence for a role of dorsal root reflexes in allodynia.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Electric Stimulation; Female; Hyperalgesia; Miotics; Mustard Plant; Nerve Fibers, Myelinated; Peptide Fragments; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Reflex; Regional Blood Flow; Rhizotomy; Skin; Spinal Nerve Roots; Sural Nerve; Vasodilation | 2001 |
Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats.
Topics: Animals; Animals, Newborn; Capsaicin; Coloring Agents; Complex Regional Pain Syndromes; Denervation; Disease Models, Animal; Edema; Electric Stimulation; Hindlimb; Hyperalgesia; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2002 |
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Temperature; Hyperalgesia; Inflammation; Knee; Male; Mice; Mice, Inbred ICR; Mustard Plant; Neurons; Pain; Pain Threshold; Peptoids; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Receptors, Drug; Recombinant Proteins; Stress, Mechanical; Time Factors; Xenopus | 2002 |
Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents.
Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Behavior, Animal; Capsaicin; Gangliosides; Hyperalgesia; Infusions, Intravenous; Injections, Spinal; Male; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2002 |
Capsaicin-sensitive primary afferents mediate responses to cold in rats with a peripheral mononeuropathy.
Topics: Animals; Cannabinoids; Capsaicin; Cold Temperature; Diterpenes; Hindlimb; Hyperalgesia; Ligation; Male; Mononeuropathies; Neurons, Afferent; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2002 |
Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain.
Topics: Adult; Aged; Capsaicin; Central Nervous System Diseases; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Neurons, Afferent; Pain Threshold; Peripheral Nervous System Diseases; Touch | 2002 |
Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity.
Topics: Animals; Bupivacaine; Capsaicin; Carrageenan; Diterpenes; Hyperalgesia; Male; Nerve Block; Peripheral Nerves; Rats; Rats, Sprague-Dawley | 2002 |
Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization.
Topics: Animals; Behavior, Animal; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Enzyme Inhibitors; Exploratory Behavior; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; Microdialysis; Pain Measurement; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spinal Cord; Sulfonamides | 2002 |
Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity.
Topics: Animals; Bee Venoms; Capsaicin; Carrageenan; Dynorphins; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Multivariate Analysis; Neurogenic Inflammation; Nociceptors; Pain; Pain Measurement; Species Specificity; Tail | 2002 |
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
Topics: Animals; Capsaicin; Cell Line; Humans; Hyperalgesia; Rats; Receptors, Drug; Recombinant Proteins; Transfection | 2002 |
Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.
Topics: Animals; Animals, Newborn; Capsaicin; Dynorphins; Enkephalins; Female; Foot Diseases; Gene Expression; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1992 |
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Female; Freund's Adjuvant; Hyperalgesia; Irritants; Mice; Morphine; Naloxone; Pain Measurement; Rats; Rats, Wistar; Uric Acid | 1992 |
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
Topics: Capsaicin; Cold Temperature; Evoked Potentials; Female; Humans; Hyperalgesia; Male; Nociceptors; Pain Measurement; Physical Stimulation; Sensory Thresholds; Time Factors | 1992 |
Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans.
Topics: Adult; Capsaicin; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Mechanoreceptors; Middle Aged; Nerve Block; Nerve Fibers, Myelinated; Neural Conduction; Pain Measurement; Sensory Thresholds; Time Factors | 1992 |
Noxious heat hyperalgesia test instrument.
Topics: Capsaicin; Diabetic Neuropathies; Hot Temperature; Humans; Hyperalgesia; Least-Squares Analysis; Sensory Thresholds; Skin | 1991 |
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms.
Topics: Adult; Aged; Anesthesia, Local; Capsaicin; Central Nervous System; Female; Humans; Hyperalgesia; Lymph; Male; Middle Aged; Nerve Fibers; Nervous System Physiological Phenomena; Neurons; Pain; Peripheral Nerves; Physical Stimulation; Psychophysics; Regional Blood Flow; Skin | 1991 |
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Intradermal; Macaca fascicularis; Nerve Fibers; Nervous System Physiological Phenomena; Nociceptors; Pain; Physical Stimulation; Skin | 1991 |
Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.
Topics: Animals; Brain; Capsaicin; Electrophysiology; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Macaca fascicularis; Nervous System Physiological Phenomena; Neurons; Spinothalamic Tracts | 1991 |
Involvement of capsaicin-sensitive neurones in hyperalgesia and enhanced opioid antinociception in inflammation.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Freund's Adjuvant; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Morphine; Narcotics; Neurons; Nociceptors; Pressure; Rats; Rats, Inbred Strains; Time Factors; Vasodilation | 1990 |
A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats.
Topics: Afferent Pathways; Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Hot Temperature; Hyperalgesia; Hyperesthesia; Lasers; Male; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Reference Values; Sensory Thresholds; Skin; Touch | 1990 |
Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin.
Topics: Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Hyperesthesia; Pain; Pain Measurement; Physical Stimulation; Time Factors | 1989 |
Heat and mechanical hyperalgesia induced by capsaicin. Cross modality threshold modulation in human C nociceptors.
Topics: Biomechanical Phenomena; Body Temperature; Capsaicin; Constriction; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Hyperesthesia; Nerve Block; Nociceptors; Pain; Physical Stimulation; Sensory Thresholds; Skin | 1989 |
Hyperalgesia mediated by peripheral opiate receptors in the rat.
Topics: Administration, Topical; Animals; Behavior, Animal; Capsaicin; Etorphine; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury.
Topics: Animals; Burns; Capsaicin; Central Nervous System; Guanethidine; Hyperalgesia; Hyperesthesia; Male; Nerve Block; Nerve Fibers; Pain; Peripheral Nerves; Procaine; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Skin | 1987 |