adenosine has been researched along with Allodynia in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.41) | 18.7374 |
| 1990's | 15 (21.13) | 18.2507 |
| 2000's | 29 (40.85) | 29.6817 |
| 2010's | 22 (30.99) | 24.3611 |
| 2020's | 4 (5.63) | 2.80 |
| Authors | Studies |
|---|---|
| Bhattarai, A; Bhola, R; Carlsson, J; Chia, LY; Christie, MJ; Christopoulos, A; Cowie-Kent, I; Danev, R; Draper-Joyce, CJ; Glukhova, A; Imlach, WL; May, LT; Miao, Y; Nguyen, ATN; O'Sullivan, K; Panel, N; Scammells, P; Sexton, PM; Thal, DM; Valant, C; Venugopal, H; Wang, J; White, PJ; Wootten, D | 1 |
| Garrett, TJ; Giancotti, LA; Harada, CM; Harmon, TA; Kolar, G; Lauro, F; Salvemini, D | 1 |
| Jeong, W; Jun, IG; Kim, K; Park, JY | 1 |
| Bennett, GJ; Chen, Z; Cuzzocrea, S; Dalgarno, R; Doyle, TM; Esposito, E; Fan, C; Hutchinson, MR; Jacobson, KA; Largent-Milnes, TM; Salvemini, D; Staikopoulos, V; Tosh, DK; Trang, T; Vanderah, TW | 1 |
| Hsieh, CL; Hsu, HC; Lin, YW; Yen, LT | 1 |
| Hsieh, CL; Huang, CP; Liao, HY; Lin, YW | 1 |
| Ichikawa, H; Omura, S; Sato, T; Sugimoto, T; Terayama, R; Tsuchiya, H; Yamaguchi, D | 1 |
| Batisti, AP; Brito, RN; Madeira, F; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Stramosk, J; Turnes, BL | 1 |
| Cuzzocrea, S; Doyle, T; Esposito, E; Jacobson, KA; Janes, K; Salvemini, D; Tosh, DK | 1 |
| Bannister, K; Chen, Z; Dickenson, AH; Doyle, T; Ford, A; Jacobson, KA; Janes, K; Little, JW; Luongo, L; Maione, S; Porreca, F; Salvemini, D; Symons-Liguori, AM; Tosh, DK; Vanderah, TW; Xie, J | 1 |
| Katz, NK; Ryals, JM; Wright, DE | 1 |
| Eisenach, JC; North, J; Rauck, RL | 1 |
| Castonguay, A; Chen, Z; Cottet, M; De Koninck, Y; Doyle, T; Egan, TM; Ford, A; Jacobson, KA; Little, JW; Salvemini, D; Symons-Liguori, AM; Tosh, DK; Vanderah, TW | 1 |
| Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY | 1 |
| Araldi, D; Ferrari, LF; Levine, JD | 2 |
| Feng, C; Yan, H; Zhang, E; Zhao, X | 1 |
| Bishnoi, M; Chopra, K; Kuhad, A | 1 |
| Alves-Filho, JC; Cunha, FQ; Cunha, TM; De Oliveira, JR; Ferreira, FI; Ferreira, SH; Lima, FO; Queiroz, RH; Valério, DA; Verri, WA | 1 |
| Dussor, G; Fields, HL; Gutierrez, T; King, T; Lai, J; Porreca, F; Vanderah, TW; Vera-Portocarrero, L | 1 |
| Horiuchi, H; Morino, T; Ogata, T; Yamamoto, H | 1 |
| Sowa, NA; Taylor-Blake, B; Zylka, MJ | 1 |
| Fredholm, BB; Hao, JX; Li, L; Schulte, G; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Zylka, MJ | 1 |
| Hahm, KD; Jeong, SM; Kim, YK; Lee, C; Leem, JG; Park, PH; Shin, JW; Song, JG | 1 |
| Bianco, MR; Cavaliere, C; Cirillo, G; Marcello, L; Merizzi, G; Papa, M; Petrosino, V; Soleti, A | 1 |
| Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J | 1 |
| Cappellacci, L; de Novellis, V; Franchetti, P; Gatta, L; Giordano, C; Grifantini, M; Guida, F; Luongo, L; Maione, S; Petrelli, R; Vita, P | 1 |
| Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J | 1 |
| Aslantas, A; Dokmeci, I; Firat, Z; Karadag, HC; Tamer, M; Ulugol, A | 1 |
| Liu, XJ; Sawynok, J; White, TD | 1 |
| Curry, R; Eisenach, JC; Hood, DD | 2 |
| Ishikawa, T; Kinoshita, H; Lambert, C; Matsui, T; Nakanishi, O; Shinohara, N; Yamamoto, S | 1 |
| Clark, AJ; Lynch, ME; Sawynok, J | 1 |
| Curry, R; Eisenach, JC; Rauck, RL | 1 |
| Battastini, AM; Bonan, CD; Crema, L; da Silva Torres, IL; Dalmaz, C; De Leon Nunes, M; Ferreira, MB; Sarkis, JJ | 1 |
| Brown, J; Chizh, BA; Cookson, LM; Dusch, M; Koppert, W; Martina, R; Puthawala, M; Schmelz, M | 1 |
| Herrero, JF; Ramos-Zepeda, G; Rosenow, S; Schröder, W | 1 |
| Collins, SD; Danhof, M; de Boer, AG; Dejongh, J; Ijzerman, AP; Schaddelee, MP | 2 |
| Benedek, G; Csullog, E; Horvath, G; Joo, G; Kekesi, G; Peter-Szabo, M | 1 |
| Baghdoyan, HA | 1 |
| Aubel, B; Bourgoin, S; Farré, A; Hamon, M; Kayser, V | 1 |
| Chen, HH; Pan, HZ | 1 |
| Cappellacci, L; de Novellis, V; Franchetti, P; Grifantini, M; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Stella, L; Vita, D | 1 |
| Akula, KK; Dhir, A; Kulkarni, SK | 1 |
| Pogatzki-Zahn, EM; Straub, H; Wenk, M; Zahn, PK | 1 |
| Chahal, P; Mudipalli, R; Rao, SS; Remes-Troche, JM | 1 |
| Green, PG; Heller, PH; Khasar, SG; Levine, JD; Taiwo, YO; Wang, JF | 1 |
| Belfrage, M; Ekblom, A; Forsberg, C; Segerdahl, M; Sjölund, KF; Sollevi, A | 1 |
| Behbehani, MM; Dollberg-Stolik, O | 1 |
| Paalzow, GH | 1 |
| Ahlgren, SC; Levine, JD | 1 |
| Gold, MS; Levine, JD; Reichling, DB; Shuster, MJ | 1 |
| Aley, KO; Green, PG; Levine, JD | 1 |
| Aley, KO; Levine, JD | 2 |
| Poon, A; Sawynok, J | 1 |
| Segerdahl, M; Sjölund, KF; Sollevi, A | 1 |
| Aley, KO; Levine, JD; Messing, RO; Mochly-Rosen, D | 1 |
| Arnold, MA; Patterson, SL; Sluka, KA | 1 |
| Arnér, S; Belfrage, M; Gordh, T; Karlsten, R; Segerdahl, M; Sjölund, KF; Solevi, A | 1 |
| Betsholtz, C; Dunwiddie, TV; Escorihuela, RM; Fernández-Teruel, A; Fredholm, BB; Giménez-Llort, L; Halldner, L; Hårdemark, A; Herlenius, E; Johansson, B; Masino, SA; Poelchen, W; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Eisenach, JC; Li, X; Sandner-Kiesling, A | 1 |
| Iwamoto, T; Miki, S; Noguchi, K; Okamoto, K; Sato, S; Senba, E; Yasuda, T; Yoshinaga, N | 1 |
| Heller, PH; Levine, JD; Taiwo, YO | 1 |
| Gordh, T; Karlsten, R; Post, C | 1 |
| Levine, JD; Taiwo, YO | 2 |
| DeLander, GE; Hopkins, CJ | 1 |
1 review(s) available for adenosine and Allodynia
| Article | Year |
|---|---|
Pain-relieving prospects for adenosine receptors and ectonucleotidases.
Topics: 5'-Nucleotidase; Acid Phosphatase; Acupuncture Therapy; Adenosine; Adenosine Monophosphate; Analgesics; Animals; Humans; Hyperalgesia; Inflammation; Neuralgia; Nociceptors; Protein Tyrosine Phosphatases; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Recombinant Proteins | 2011 |
10 trial(s) available for adenosine and Allodynia
| Article | Year |
|---|---|
Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome.
Topics: Adenosine; Adult; Analgesics; Chronic Pain; Clonidine; Complex Regional Pain Syndromes; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Spinal; Male; Middle Aged; Pain Measurement; Treatment Outcome | 2015 |
Dose response of intrathecal adenosine in experimental pain and allodynia.
Topics: Adenosine; Administration, Topical; Adult; Aminophylline; Analgesics, Non-Narcotic; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Infusions, Intravenous; Injections, Spinal; Male; Middle Aged; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists | 2002 |
Intravenous adenosine alleviates neuropathic pain: a double blind placebo controlled crossover trial using an enriched enrolment design.
Topics: Adenosine; Adult; Analgesics; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Infusions, Intravenous; Middle Aged; Neuralgia; Pain; Pain Measurement; Pain Threshold; Placebos; Sensation; Sensory Thresholds; Time; Time Factors; Treatment Outcome | 2003 |
Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain.
Topics: Adenosine; Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Intravenous; Injections, Spinal; Male; Middle Aged; Neuralgia; Pain Measurement | 2003 |
The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitization.
Topics: Adenosine; Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Male | 2004 |
Adenosine modulates oesophageal sensorimotor function in humans.
Topics: Adenosine; Adult; Biomechanical Phenomena; Double-Blind Method; Electric Impedance; Esophagus; Female; Heart Rate; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Pain Threshold; Sensory Thresholds; Young Adult | 2009 |
Systemic adenosine attenuates touch evoked allodynia induced by mustard oil in humans.
Topics: Adenosine; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Male; Mustard Plant; Plant Extracts; Plant Oils; Plants, Medicinal; Touch | 1995 |
Adenosine reduces secondary hyperalgesia in two human models of cutaneous inflammatory pain.
Topics: Adenosine; Adult; Analgesics; Burns; Burns, Chemical; Cross-Over Studies; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia; Male; Mustard Plant; Neurons, Afferent; Pain Measurement; Plant Extracts; Plant Oils; Skin | 1999 |
Systemic adenosine infusion reduces the area of tactile allodynia in neuropathic pain following peripheral nerve injury: a multi-centre, placebo-controlled study.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Analgesics; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Placebos; Treatment Outcome | 2001 |
Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
Topics: Adenosine; Adult; Analgesics; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Spinal; Male; Middle Aged; Pain; Pain Threshold | 2002 |
60 other study(ies) available for adenosine and Allodynia
| Article | Year |
|---|---|
Positive allosteric mechanisms of adenosine A
Topics: Adenosine; Allosteric Regulation; Analgesia; Animals; Binding Sites; Disease Models, Animal; Female; GTP-Binding Protein alpha Subunit, Gi2; Hyperalgesia; Lipids; Male; Neuralgia; Protein Stability; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Signal Transduction | 2021 |
Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.
Topics: Adenosine; Adenosine Kinase; Animals; Hyperalgesia; Inflammasomes; Interleukin-1beta; NLR Proteins; Oxadiazoles; Rats; Rats, Sprague-Dawley; Sphingosine-1-Phosphate Receptors; Spinal Cord Dorsal Horn; Thiophenes | 2022 |
Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neuralgia; Neuroprotective Agents; Physical Stimulation; Rats; Rats, Sprague-Dawley; Vincristine | 2020 |
Chronic Morphine-Induced Changes in Signaling at the A
Topics: Adenosine; Analgesics; Animals; Drug Tolerance; Female; Hyperalgesia; Interleukin-10; Interleukin-1beta; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Signal Transduction; Substance Withdrawal Syndrome; Time Factors | 2020 |
Targeting ASIC3 for Relieving Mice Fibromyalgia Pain: Roles of Electroacupuncture, Opioid, and Adenosine.
Topics: Acid Sensing Ion Channels; Adenosine; Analgesics, Opioid; Animals; Electroacupuncture; Fibromyalgia; Ganglia, Spinal; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pain; Pain Management; Signal Transduction | 2017 |
Electroacupuncture Attenuates Induction of Inflammatory Pain by Regulating Opioid and Adenosine Pathways in Mice.
Topics: Adenosine; Analgesics, Opioid; Animals; Astrocytes; Cyclooxygenase 2; Disease Models, Animal; Electroacupuncture; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Mice; NF-kappa B; Pain; Pain Management; Protein Kinase C-epsilon; Rats; Receptor for Advanced Glycation End Products; S100 Calcium Binding Protein beta Subunit; Signal Transduction; Spinal Cord Dorsal Horn | 2017 |
Effect of adenosine A1 receptor agonist on the enhanced excitability of spinal dorsal horn neurons after peripheral nerve injury.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Analysis of Variance; Animals; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Tibial Neuropathy; Time Factors | 2014 |
Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain.
Topics: Adenosine; Animals; Benzoxazines; Disease Models, Animal; Edema; Freund's Adjuvant; Hyperalgesia; Immersion; Indoles; Inflammation; Male; Mice; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Neurobiology; Pain Measurement; Receptor, Adenosine A1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Water Purification | 2015 |
A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Hyperalgesia; Male; NADP; Neuralgia; Neuroglia; NF-kappa B; Oxidation-Reduction; Paclitaxel; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha | 2014 |
Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Topics: Adenosine; Animals; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Medulla Oblongata; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Naloxone; Neuralgia; Neurons; Pain Measurement; Pain Threshold; Purinergic P1 Receptor Antagonists; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Spinal Cord; Time Factors | 2015 |
Central or peripheral delivery of an adenosine A1 receptor agonist improves mechanical allodynia in a mouse model of painful diabetic neuropathy.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine Monophosphate; Analgesics, Non-Narcotic; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Foot; Ganglia, Spinal; Hindlimb; Hydrolysis; Hyperalgesia; Injections, Spinal; Male; Mice; Neurons; Receptor, Adenosine A1; Spinal Cord; Touch | 2015 |
Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hyperalgesia; K Cl- Cotransporters; Male; Mice; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatica; Signal Transduction; Spinal Nerve Roots; Symporters; Thiazoles; Thioglycolates | 2015 |
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system.
Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease Models, Animal; Edema; Freund's Adjuvant; Hyperalgesia; Interleukin-1beta; Medicine, Chinese Traditional; Mice; Monoterpenes; Motor Activity; Paclitaxel; Pain Measurement; Theobromine; Theophylline; Xanthines | 2015 |
Adenosine-A1 receptor agonist induced hyperalgesic priming type II.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1 | 2016 |
Role of A3 adenosine receptor in diabetic neuropathy.
Topics: Action Potentials; Adenosine; Animals; Blood Glucose; Body Weight; Diabetic Neuropathies; Disease Models, Animal; Eating; Hyperalgesia; Male; Mice; Muscle, Skeletal; Neural Conduction; NF-kappa B; Pain Threshold; Receptor, Adenosine A3; Sciatic Nerve; Spinal Cord; Streptozocin | 2016 |
Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor α in the Rat.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Monophosphate; Animals; Chronic Pain; Dinoprostone; Disease Models, Animal; DNA, Antisense; Estrogen Receptor alpha; Female; Gene Expression Regulation; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Sprague-Dawley; Ryanodine; Sex Factors; Time Factors; Xanthines | 2017 |
Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain.
Topics: Adenosine; Animals; Cerebral Cortex; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred Strains; Pain Measurement; Pain Threshold; Selective Serotonin Reuptake Inhibitors; Streptozocin; Thiophenes; Touch | 2009 |
Fructose-1,6-bisphosphate reduces inflammatory pain-like behaviour in mice: role of adenosine acting on A1 receptors.
Topics: Adenosine; Analgesics; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fructosediphosphates; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Receptor, Adenosine A1 | 2009 |
Unmasking the tonic-aversive state in neuropathic pain.
Topics: Adenosine; Analgesics; Analysis of Variance; Animals; Calcium Channel Blockers; Clonidine; Conditioning, Classical; Conditioning, Psychological; Disease Models, Animal; Drug Administration Schedule; Hyperalgesia; Injections, Spinal; Male; Neuralgia; omega-Conotoxins; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Reward; Time Factors | 2009 |
Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Female; Hyperalgesia; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Spinal Cord; Spinal Cord Compression; Treatment Outcome; Xanthines | 2010 |
Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Animals; Cell Membrane; Ganglia, Spinal; Hydrolysis; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Nerve Endings; Nociceptors; Pain; Presynaptic Terminals; Receptor, Adenosine A1; Sciatic Nerve; Skin | 2010 |
Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Carrageenan; Female; Ganglia, Spinal; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Pain; Pain Threshold; Phenethylamines; Receptor, Adenosine A2A; Sex Characteristics; Triazines; Triazoles | 2010 |
Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats.
Topics: 4-Aminopyridine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Humans; Hyperalgesia; Injections, Spinal; Male; Neurons; Pain; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2011 |
Neuropathic pain and reactive gliosis are reversed by dialdehydic compound in neuropathic pain rat models.
Topics: Adenosine; Adenosine Triphosphate; Affinity Labels; Aldehydes; Analgesics; Animals; Astrocytes; Chronic Disease; Disease Models, Animal; Drug Discovery; Gliosis; Hyperalgesia; Lumbar Vertebrae; Male; Microglia; Neuralgia; Rats; Rats, Sprague-Dawley; Spinal Cord | 2012 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; Fenclonine; Hyperalgesia; Male; Mice; Morphine; Pain, Postoperative; Receptor, Adenosine A1; Xanthines; Yohimbine | 2013 |
5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cardiovascular System; Humans; Hyperalgesia; Mice; Microglia; Motor Activity; Neuralgia; Neuroglia; Norbornanes; Receptor, Adenosine A1; Sciatic Nerve; Xanthines | 2012 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase Inhibitors; Animals; Caffeine; Exercise Therapy; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Reflex Sympathetic Dystrophy; Swimming; Triazines; Triazoles; Xanthines | 2013 |
Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Interactions; Female; Hyperalgesia; Neuralgia; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nerves; Phosphodiesterase Inhibitors; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2002 |
Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Nerve Crush; Nerve Fibers, Unmyelinated; Neuralgia; Neurons, Afferent; Nociceptors; Oxidopamine; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Skin; Spinal Nerves; Sympathetic Fibers, Postganglionic | 2002 |
Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord | 2003 |
Effect of drugs active at adenosine receptors upon chronic stress-induced hyperalgesia in rats.
Topics: Adenosine; Animals; Chronic Disease; Hyperalgesia; Male; Pain Measurement; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Stress, Physiological; Xanthines | 2003 |
Spinal vs. supraspinal antinociceptive activity of the adenosine A(1) receptor agonist cyclopentyl-adenosine in rats with inflammation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Analgesics; Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials, Motor; Female; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Reflex, Monosynaptic; Spinal Cord; Spinal Nerve Roots; Stress, Mechanical; Theophylline | 2004 |
Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat.
Topics: Adenosine; Analgesics; Animals; Hyperalgesia; Male; Mononeuropathies; Pain Measurement; Rats | 2004 |
Dose-independent antinociceptive interaction of endogenous ligands at the spinal level.
Topics: Adenosine; Agmatine; Analgesics; Animals; Carrageenan; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Spinal; Kynurenic Acid; Ligands; Male; Pain Threshold; Rats; Rats, Wistar; Reaction Time | 2004 |
Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Algorithms; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Deoxyadenosines; Hyperalgesia; Injections, Intravenous; Male; Neuralgia; Rats; Time Factors | 2005 |
Hyperalgesia induced by REM sleep loss: a phenomenon in search of a mechanism.
Topics: Acetylcholine; Adenosine; Anxiety; Chronic Disease; Depression; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Nociceptors; Polysomnography; Pons; Prevalence; Reticular Formation; Sleep Deprivation; Sleep Initiation and Maintenance Disorders; Sleep, REM | 2006 |
Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy.
Topics: Adenosine; Analgesics; Animals; Area Under Curve; Caffeine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Male; Oxadiazoles; Pain Measurement; Pain Threshold; Piperazines; Psychomotor Performance; Pyrazoles; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Vocalization, Animal | 2007 |
Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats.
Topics: Adenosine; Animals; Animals, Newborn; Anxiety; Avoidance Learning; Behavior, Animal; Body Temperature Regulation; Brain; Caffeine; Central Nervous System Stimulants; Female; Hot Temperature; Hyperalgesia; Male; Memory; Motor Activity; Pain Measurement; Pain Threshold; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Time Factors | 2007 |
The antinociceptive effect of 2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Analgesics; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Pain; Pain Threshold; Rats; Rats, Wistar | 2007 |
Systemic administration of adenosine ameliorates pentylenetetrazol-induced chemical kindling and secondary behavioural and biochemical changes in mice.
Topics: Adenosine; Adenosine Deaminase; Animals; Anticonvulsants; Behavior, Animal; Hyperalgesia; Hypothalamo-Hypophyseal System; Kindling, Neurologic; Lipid Peroxidation; Male; Memory; Mice; Motor Activity; Pentylenetetrazole; Pituitary-Adrenal System | 2007 |
Adenosine A1 but not A2a receptor agonist reduces hyperalgesia caused by a surgical incision in rats: a pertussis toxin-sensitive G protein-dependent process.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hyperalgesia; Male; Pain, Postoperative; Pertussis Toxin; Phenylisopropyladenosine; Physical Stimulation; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Surgical Procedures, Operative; Vasodilator Agents | 2007 |
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
Topics: Adenosine; Adenylate Cyclase Toxin; Amino Acid Sequence; Analgesics; Animals; Antihypertensive Agents; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Hyperalgesia; Male; Molecular Sequence Data; Pertussis Toxin; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1995 |
Partial sciatic nerve ligation results in an enlargement of the receptive field and enhancement of the response of dorsal horn neurons to noxious stimulation by an adenosine agonist.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Caffeine; Causalgia; Electrophysiology; Hyperalgesia; Male; Neurons; Nociceptors; Pain Measurement; Patch-Clamp Techniques; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Stimulation, Chemical; Vasodilator Agents | 1994 |
Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Hyperalgesia; Male; Methyltyrosines; Norepinephrine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reserpine; Sulpiride; Theophylline; Tyrosine 3-Monooxygenase | 1994 |
Mechanical hyperalgesia in streptozotocin-diabetic rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylate Cyclase Toxin; Animals; Diabetes Mellitus, Experimental; Dideoxyadenosine; Dinoprostone; GTP-Binding Proteins; Guanosine Diphosphate; Hyperalgesia; Indomethacin; Male; Mechanoreceptors; Pain; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Thionucleotides; Virulence Factors, Bordetella | 1993 |
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.
Topics: Adenosine; Animals; Capsaicin; Cells, Cultured; Dinoprostone; Ganglia, Spinal; Hyperalgesia; Kinetics; Male; Membrane Potentials; Neurons; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Serotonin; Sodium Channels; Tetrodotoxin; Thromboxane B2 | 1996 |
Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal.
Topics: Adenosine; Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Rats; Rats, Sprague-Dawley; Xanthines | 1995 |
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine | 1997 |
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat.
Topics: Adenosine; Adenosine Deaminase; Animals; Antihypertensive Agents; Carrageenan; Deoxyadenosines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Enzyme Inhibitors; Excipients; Hot Temperature; Hyperalgesia; Male; Neuritis; Neurons; Nociceptors; Pentostatin; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Tubercidin | 1998 |
Role of protein kinase A in the maintenance of inflammatory pain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Adenylyl Cyclase Inhibitors; Animals; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Drug Administration Schedule; Enzyme Inhibitors; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; Nociceptors; Pain Threshold; Phenethylamines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1999 |
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.
Topics: Adenosine; Animals; Carrageenan; Dinoprostone; Enzyme Inhibitors; Hindlimb; Hyperalgesia; Inflammation; Isoenzymes; Male; Nociceptors; Pain; Phenethylamines; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2000 |
A novel transverse push-pull microprobe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Animals; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Male; Microdialysis; Nitrophenols; Physical Stimulation; Posterior Horn Cells; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Spinal Cord; Theophylline | 2001 |
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.
Topics: Adenosine; Animals; Anxiety; Autoradiography; Behavior, Animal; Caffeine; Hippocampus; Hyperalgesia; Hypoxia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Purinergic P1 | 2001 |
Morphine-induced spinal release of adenosine is reduced in neuropathic rats.
Topics: Adenosine; Analgesics, Opioid; Animals; Behavior, Animal; Dipyridamole; Dose-Response Relationship, Drug; Hyperalgesia; Male; Morphine; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves; Synaptosomes; Vasodilator Agents | 2001 |
A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception.
Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Guinea Pigs; Hyperalgesia; Immunohistochemistry; In Vitro Techniques; Male; Proto-Oncogene Proteins c-fos; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Xanthines | 2001 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes | 1992 |
Local antinociceptive and hyperalgesic effects in the formalin test after peripheral administration of adenosine analogues in mice.
Topics: Absorption; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Drug Interactions; Extremities; Hyperalgesia; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain Measurement; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic; Theophylline | 1992 |
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dinoprostone; Epoprostenol; Hyperalgesia; Male; Phosphorylation; Protein Kinases; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Second Messenger Systems; Sensory Thresholds; Thionucleotides | 1991 |
Direct cutaneous hyperalgesia induced by adenosine.
Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Intradermal; Male; Rats; Rats, Inbred Strains; Skin Diseases | 1990 |
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Nociceptors; Spinal Cord; Theophylline; Xanthines | 1986 |