paclitaxel has been researched along with Allodynia in 200 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 18 (9.00) | 29.6817 |
| 2010's | 123 (61.50) | 24.3611 |
| 2020's | 59 (29.50) | 2.80 |
| Authors | Studies |
|---|---|
| Koizumi, S; Komatsu, R; Mizuno, K; Shibata, K; Takanashi, K | 1 |
| Arora, V; Asgar, J; Chung, MK; Kumari, S; Li, T; Wang, S | 1 |
| Khan, A; Khan, AU; Khan, S; Khan, SZ; Naveed, M; Rehman, ZU; Shal, B; Ullah, R | 1 |
| Cortez, IL; Cunha, TM; Dos Santos, JC; Gomes, FIF; Gomes, FV; Guimarães, FS; Lopes, AHP; Mechoulam, R; Silva, CEA; Silva, NR | 1 |
| Araldi, D; Bonet, IJM; Green, PG; Levine, JD; Staurengo-Ferrari, L | 1 |
| Albrecht, PJ; Carey, L; Dockum, M; Hillard, CJ; Hohmann, AG; Houk, G; Lin, X; Mackie, K; Makriyannis, A; Rice, FL; Romero, J; Ruggiero, E; Xu, Z | 1 |
| Adamek, P; Bhattacharyya, A; Heles, M; Palecek, J; Pontearso, M; Slepicka, J | 1 |
| Alexiou, A; Ashraf, GM; Baeesa, SS; Karmakar, V; Mohammad, FS; Sivakumar, SR | 1 |
| Feng, S; Mao, M; Wang, J; Wang, X; Zhang, S; Zhou, F | 1 |
| Ahsan Halim, S; Al-Harrasi, A; Ali, G; Khan, A; Rasheed, A; Subhan, F; Ullah, R | 1 |
| Adaralegbe, A; Bekker, A; Bono, J; Jia, S; Pan, Z; Tao, YX; Tenorio, C; Wang, B; Wei, G; Zheng, B | 1 |
| Cubillos-Ruiz, JR; Dougherty, PM; Fonseca, MM; Morgan, JW; Pennypacker, SD; Romero-Sandoval, EA; Strowd, RE | 1 |
| Kang, DW; Kim, HW; Lee, CJ; Lee, GS; Lee, SY; Neupane, C; Noh, C; Park, JB; Park, KD; Park, SE; Pham, TL; Sharma, R; Shin, HJ | 1 |
| Cavalli, J; Cristina Dalazen Gonçalves, E; Daniele Bobermin, L; de Assis, PM; Dutra, RC; Gomez, MV; Quincozes-Santos, A; Raposo, NRB | 1 |
| Allegretti, M; Amendola, PG; Aramini, A; Beccari, A; Benedetti, E; Brandolini, L; Bugatti, A; Caruso, A; Castelli, V; Cimini, A; Cocchiaro, P; Cristiano, C; Cunha, TM; d'Angelo, M; D'Egidio, F; Giorgio, C; Iaconis, D; Manelfi, C; Novelli, R; Quadros, AU; Ruocco, A; Russo, R; Sirico, A; Talarico, C | 1 |
| El-Tanbouly, DM; El-Yamany, MF; Gendy, AM; Nasser, AH | 1 |
| Gao, SJ; Li, DY; Liu, DQ; Mei, W; Song, FH; Sun, J; Wu, JY; Zhang, LQ; Zhou, YQ | 1 |
| Chen, Y; Gan, P; Lu, R; Wang, Y | 1 |
| Alan, A; Bahar, D; Gonen, ZB; Onder, GO; Saraymen, B; Sarica, ZS; Sezer, G; Yay, AH; Yilmaz, S | 1 |
| Chen, X; Jiang, Z; Xu, Y | 1 |
| He, L; Kume, M; Madsen, TM; Munro, G; Mwirigi, JM; Petersen, KA; Price, TJ; Sankaranarayanan, I; Tavares-Ferreira, D | 1 |
| Itoh, K; Schiller, PW; Shimoyama, M; Toyama, S | 1 |
| Huang, Y; Li, W; Ouyang, X; Shen, X; Wang, J; Xu, R; Zhao, X; Zhu, D | 1 |
| Cheng, JK; Cho, WL; Hsieh, MC; Lai, CY; Lin, KH; Lin, LT; Lin, TB; Nie, ST; Peng, HY; Wang, HH; Yang, PS; Yeh, CM | 1 |
| Burton, MD; Mejia, GL; Mwirigi, JM; Price, TJ; Sankaranarayanan, I; Tavares-Ferreira, D | 1 |
| Ba, X; Hao, Y; Ho, IHT; Jiang, C; Li, N; Li, R; Liu, X; Sun, W; Wang, J; Wu, S; Xiao, L; Xiong, D | 1 |
| Ardisson-Araújo, DMP; Becker, G; Brusco, I; de Andrade, CM; Machado-De-Avila, RA; Oliveira, MS; Oliveira, SM; Palma, TV; Pillat, MM; Sampaio, TB; Scussel, R; Steiner, BT | 1 |
| Chou, PR; Hsieh, MC; Huang, SH; Lu, IC; Tai, MH; Wang, SH; Wu, SH | 1 |
| Khan, A; Khan, MI; Khan, S; Li, CH; Luo, Y; Seo, EK; Shah, K; Wang, F; Zafar, S; Zhang, L | 1 |
| Bang, S; Bortsov, A; Breglio, A; Buchheit, T; Guo, R; Huh, Y; Ji, RR; Jun Huang, T; Matsuoka, Y; Reinecke, J; Wehling, P; Xu, J | 1 |
| Bustos-Quevedo, G; Constandil, L; Hernández, A; Lobos, N; Lux, S; Marcos, JL; Pelissier, T; Zepeda, RJ | 1 |
| Chen, X; Gao, Y; Lin, P; Lu, Q; Mei, C; Miao, M; Ni, F; Pan, C; Wu, W; Xu, J; Xu, L; Xu, Y; Yu, Y | 1 |
| Ahmad, A; Boitano, S; DeFea, KA; Dussor, G; Kume, M; Price, TJ; Vagner, J | 1 |
| Araldi, D; Bonet, IJM; Green, PG; Levine, JD | 1 |
| Lei, HY; Lian, WY; Lu, ZP; Xu, SY; Zou, JQ | 1 |
| Akbarali, HI; Damaj, MI; Jessup, D; Thakker, S; Woods, K | 1 |
| Ben-Salem, S; Bie, B; Borjini, N; Chen, J; Cheng, J; Dai, Y; Huang, P; Lin, F; Olman, M; Xu, J; Zhang, L | 1 |
| Berta, T; Gao, YJ; Ling, Y; Liu, X; Tonello, R | 1 |
| Antoniazzi, CT; Araújo, DMPA; de Almeida, AS; De Prá, SD; Ferreira, J; Kudsi, SQ; Lückemeyer, DD; Milioli, AM; Oliveira, SM; Pereira, GC; Rigo, FK; Trevisan, G | 1 |
| Diester, CM; Karim-Nejad, L; Legakis, LP; Negus, SS; Townsend, EA | 1 |
| Christensen, S; Giuvelis, D; Huynh, PN; McIntosh, JM; Tucker, KL | 1 |
| Araldi, D; Ferrari, LF; Green, PG; Levine, JD | 1 |
| Chang, LY; Chang, MS; Chen, LH; Chen, YF; Hsu, YH; Lin, CK; Lin, PC; Shen, MR; Wang, HH; Yeh, YM | 1 |
| Bai, XH; Deng, J; Ding, HH; Liu, M; Luo, DX; Mai, JW; Ruan, XC; Xin, WJ; Xu, T; Yang, YL; Zhang, SB; Zhang, XQ; Zhang, XZ | 1 |
| Berta, T; Lee, SH; Liu, X; Strong, JA; Tonello, R; Wang, M; Xie, W; Zhang, JM | 1 |
| Chen, N; Chen, SP; Li, DY; Liu, DQ; Sun, J; Tian, YK; Wang, XM; Ye, DW; Zhou, YQ | 1 |
| Abe, K; Chiba, T; Kamata, Y; Kambe, T; Kawakami, K; Taguchi, K; Yamamoto, K | 1 |
| Chen, D; Huang, J; Kang, S; Wu, S; Xie, J; Xing, W; Yan, F; Zeng, W | 1 |
| Finn, DP; Masocha, W; Okine, BN; Thomas, A | 1 |
| Andoh, T; Komatsu, K; Kurokawa, Y; Toume, K; Yu, H | 1 |
| Crystal, JD; Hohmann, AG; Iyer, V; Mackie, K; Slivicki, RA; Thomaz, AC | 1 |
| Chung, CG; Hong, YB; Jeong, DJ; Kim, C; Kim, DH; Kim, JK; Kim, YY; Koh, H; Lee, SB; Shin, DJ; Um, JH; Yoon, JH; Yun, J | 1 |
| Abdi, S; Back, S; Bae, J; Cervantes, CL; Dougherty, PM; Hwang, SH; Jun, S; Jung, YS; Kim, HK; Kim, MJ; Kim, MS; Lee, H; Lee, SE; Lee, SH; Lee, SW; Park, JI | 1 |
| Aboulhosn, R; Adel, A; Bagdas, D; Caillaud, M; Contreras, KM; Damaj, MI; Khalefa, T; Mann, JA; Neddenriep, B; Roberts, JL; Toma, W; Ulker, E; White, AB | 1 |
| Araldi, D; Bogen, O; Bonet, IJM; Levine, JD | 1 |
| Alberti, P; Ballarini, E; Canta, A; Cavaletti, G; Chiorazzi, A; Fumagalli, G; Guarnieri, C; Marmiroli, P; Meregalli, C; Monza, L; Oggioni, N; Pozzi, E; Rodriguez-Menendez, V; Scali, C | 1 |
| Egashira, N; Kawashiri, T; Kobayashi, D; Nakamura, H; Shimazoe, T; Uchida, M | 1 |
| Li, D; Li, XJ; Ma, Y; Shen, YJ; Sun, L; Wang, H; Xia, J; Xiong, YC; Xu, Y | 1 |
| Imai, S; Iwamitsu, Y; Koyanagi, M; Matsubara, K; Matsumoto, M; Moriya, A; Nakagawa, S; Nakagawa, T; Nakazato, Y; Ogihara, T; Saigo, M; Yonezawa, A | 1 |
| Choi, W; Go, EJ; Jeong, D; Kim, M; Kim, YH; Lee, H; Park, CK; Son, DB; Suh, JW | 1 |
| Brenner, C; Hamity, MV; Hammond, DL; Schmidt, MS; Walder, RY; White, SR | 1 |
| Andoh, T; Kato, M; Komatsu, K; Kuraishi, Y; Toume, K; Uta, D | 1 |
| Falconer, D; Höke, A; Reed, N; Turkiew, E | 1 |
| King, KM; Myers, AM; Soroka-Monzo, AJ; Tallarida, RJ; Tuma, RF; Walker, EA; Ward, SJ | 1 |
| Hayashi, T; Irie, K; Kimura, N; Kochi, A; Matsuo, K; Mishima, K; Myose, T; Nakamura, Y; Nakano, T; Sano, K; Satho, T; Takase, Y; Yamashita, Y | 1 |
| Adjei, S; Amoateng, P; Kretchy, IA; Kukuia, KKE; N'Guessan, BB; Osei-Safo, D; Sarkodie, JA | 1 |
| Calixto, JB; Costa, R; Freitas, CS; Manjavachi, MN; Matias, DO; Passos, GF; Segat, GC | 1 |
| Di Cesare Mannelli, L; Ghelardini, C; Maresca, M; Micheli, L; Mulinacci, N; Pieraccini, G; Tenci, B | 1 |
| Colvin, L; Galley, HF; Lowes, DA; McCormick, B; Torsney, C; Wilson, KL | 1 |
| Berman, BM; Lao, L; Li, A; Ren, K; Xin, J; Zhang, RX; Zhang, Y | 1 |
| Bagdas, D; Bigbee, JW; Chen, ZJ; Damaj, MI; Del Fabbro, E; Fang, X; Gewirtz, DA; Kyte, SL; Lichtman, AH; Meade, JA; Schurman, LD; Toma, W | 1 |
| Bai, X; Chen, X; Huang, Z; Liu, C; Nie, B; Ouyang, H; Wu, S; Xie, M; Xin, W; Xu, T; Zeng, W; Zhang, S | 1 |
| Choi, J; Jang, JU; Jeon, C; Kim, SK; Kim, W; Lee, JH; Lee, K; Quan, FS | 1 |
| Blake, A; Chow, E; DeAngelis, C; Diaz, P; Lao, N; Malek, L; O'Hearn, S; Wan, BA | 1 |
| Cassidy, RM; Dougherty, PM; Edwards, DD; Harrison, DS; Johansson, CA; Li, Y; North, RY; Rao, G; Rhines, LD; Tatsui, CE; Zhang, H | 1 |
| Alberti, P; Arnold, WD; Cavaletti, G; Chen, M; Chiorazzi, A; Chodisetty, V; Costa, O; de Bruijn, P; Florea, T; Gibson, AA; Hong, KW; Hu, S; Huang, KM; Leblanc, AF; Lustberg, MB; Mathijssen, RH; Pioso, MS; Reinbolt, RE; Sparreboom, A; Sprowl, JA; Sucheston-Campbell, LE | 1 |
| Legakis, LP; Negus, SS | 1 |
| Cheng, X; Dougherty, PM; Heijnen, CJ; Huo, X; Kavelaars, A; Li, Y; Mei, F; Singhmar, P | 1 |
| Augusto, PSA; Coelho, MM; Costa, FC; Costa, SOAM; de Fátima, Â; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF | 1 |
| Fox, DA; Huang, P; Li, Y; Lin, F; Rosenquist, R; Saunders, TL; Xie, M; Xu, J; Zhang, L | 1 |
| Duggett, NA; Flatters, SJL; Griffiths, LA; Pitcher, AL | 1 |
| Au, NPB; Chine, VB; Kumar, G; Ma, CHE | 1 |
| Ahmed, LA; Al-Massri, KF; El-Abhar, HS | 2 |
| Domoto, R; Kawabata, A; Nakashima, K; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H; Yamanishi, H; Yamasoba, D | 1 |
| Ba, X; Hao, Y; Jin, G; Luo, X; Peng, Y; Wang, J; Yang, S; Zhou, S | 1 |
| Boujedaini, N; Mensah-Nyagan, AG; Meyer, L; Patte-Mensah, C; Vitet, L | 1 |
| Imano, M; Kato, N; Koumoto, YI; Matsumoto, M; Nishida, S; Satou, T; Takeda, T; Tsubaki, M; Yasuhara, S | 1 |
| Albadri, S; Alberio, L; Barsotti, N; Beltrame, M; Bercier, V; Boender, AJ; Colecraft, HM; Contestabile, A; Del Bene, F; Di Luca, M; Ji, Y; Khanna, R; Kukovetz, K; Locarno, A; Luo, S; Marcello, E; Moleri, S; Moroni, A; Moutal, A; Pasqualetti, M; Pelucchi, S; Porro, A; Romani, G; Romano, E; Saponaro, A; Simeoni, F; Thiel, G; Tonini, R | 1 |
| Bie, B; Foss, JF; Hocevar, M; Naguib, M; Wu, J | 1 |
| Adamek, P; Heles, M; Palecek, J | 1 |
| Berta, T; Lee, SH; Tonello, R | 1 |
| Carey, LM; Dhopeshwarkar, AS; Hohmann, AG; Li, AL; Lin, X; Liu, Y; Mackie, K; Makriyannis, A; Nikas, SP; Thomaz, AC | 1 |
| Arora, M; Deng, M; Ganugula, R; Kumar, MNVR; Pan, HL | 1 |
| Boucher, M; Cook, JC; Fenyk-Melody, J; Liu, CN; Mechanic, J; Pardo, ID; Peng, Q; Schaevitz, L; Shoieb, A; Somps, C; Vitsky, A | 1 |
| Bekker, A; Cao, J; Chen, L; Du, S; Gu, X; Mao, Q; Mo, K; Sun, L; Tao, YX; Wu, S | 1 |
| Dantzer, R; Edralin, JD; Heijnen, CJ; Kavelaars, A; Laumet, G | 1 |
| Hohmann, AG; Mali, SS; Slivicki, RA; Xu, Z | 1 |
| Ishiuchi, K; Makino, T; Ohsawa, M; Tanimura, Y; Yoshida, M | 1 |
| Abdi, S; Hwang, SH; Kim, E; Kim, HK | 1 |
| Brenneman, DE; Kinney, WA; Ward, SJ | 1 |
| Andoh, T; Bai, Y; Ge, Y; Hanazawa, S; Hou, Z; Kato, M; Komatsu, K; Maesaka, M; Toume, K; Yu, H | 1 |
| Bang, S; He, Q; Huh, Y; Ji, RR; Luo, X; Matsuda, M; Zhang, L | 1 |
| Braga, AV; Coelho, MM; Costa, SOAM; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF | 1 |
| Aypar, U; Canbay, O; Celebi, N; Cil, H; Cil, O; Onur, R | 1 |
| Baamonde, A; Hidalgo, A; Lastra, A; Menéndez, L; Pevida, M | 1 |
| Katsuyama, S; Kishikawa, Y; Nakamura, H; Sato, K; Yagi, T | 1 |
| Abe, K; Chiba, T; Hama, T; Hara, T; Ikeno, S; Kawakami, K; Makabe, A; Taguchi, K; Utsunomiya, I | 1 |
| Egashira, N; Oishi, R | 1 |
| Bennett, GJ; Bryant, L; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Ryerse, J; Salvemini, D | 1 |
| Mensah-Nyagan, AG; Meyer, L; Patte-Mensah, C; Taleb, O | 1 |
| Day, JM; Foster, PA; Kasprzyk, PG; Meyer-Losic, F; Newman, SP; Purohit, A; Reed, MJ | 1 |
| Astruc-Diaz, F; Bie, B; Brown, DL; Diaz, P; Naguib, M; Wu, J; Xu, JJ; Yang, H | 1 |
| Edafiogho, IO; Masocha, W; Thangamani, D | 1 |
| Akita, H; Noda, K; Ogata, M; Saji, M | 1 |
| Bonanno, G; Di Cesare Mannelli, L; Fariello, RG; Farina, C; Ghelardini, C; Milanese, M; Misiano, P; Pittaluga, A | 1 |
| Deng, L; Hohmann, AG; Lai, YY; Makriyannis, A; Rahn, EJ; Thakur, GA; Vemuri, K; Zvonok, AM | 1 |
| Cornett, BL; Deng, L; Guindon, J; Hohmann, AG; Mackie, K; Makriyannis, A | 1 |
| Cleeland, C; Heijnen, CJ; Huo, XJ; Kavelaars, A; Krukowski, K; Mao-Ying, QL; Price, TJ; Zhou, W | 1 |
| Inoue, K; Inoue, T; Nagata, K; Ochi-ishi, R; Tozaki-Saitoh, H; Tsuda, M | 1 |
| Balkaya, M; Boehmerle, W; Endres, M; Huehnchen, P; Peruzzaro, S | 1 |
| Futagami, M; Hirakawa, H; Matsumura, Y; Mizunuma, H; Shigeto, T; Yokoyama, Y | 1 |
| Cuzzocrea, S; Doyle, T; Esposito, E; Jacobson, KA; Janes, K; Salvemini, D; Tosh, DK | 1 |
| Masocha, W | 1 |
| Cui, Y; Huang, ZZ; Li, D; Ling, YZ; Wei, JY; Xin, WJ; Zhang, XZ; Zhu, HQ | 1 |
| Filipek, B; Sałat, K | 1 |
| Basbaum, AI; Bráz, JM; Guan, Z; Rubenstein, JL; Wang, X | 1 |
| Gui, Q; Li, D; Xia, S; Xu, C; Yu, S; Zhuang, L | 1 |
| Masocha, W; Parvathy, SS | 2 |
| Flatters, SJ; Griffiths, LA | 1 |
| Aki, M; Junpei, O; Kazumi, Y; Masato, H; Mika, F; Teruo, H; Tomohisa, M; Tsutomu, S | 1 |
| Liu, XG; Pang, RP; Shen, KF; Wei, XH; Xu, J; Zhu, HQ | 1 |
| Adamek, P; Cassidy, RM; Cata, JP; Dougherty, PM; Ghetti, A; Harrison, DS; Jawad, AB; Kennamer-Chapman, RM; Kosturakis, AK; Li, Q; Li, Y; Mrozkova, P; Palecek, J; Rhines, LD; Sapire, K; Tatsui, CE; Yan, J; Zhang, H | 1 |
| Calò, G; Di Cesare Mannelli, L; Ghelardini, C; Guerrini, R; Micheli, L; Rizzi, A; Trapella, C | 1 |
| Heijnen, CJ; Huo, X; Kavelaars, A; Krukowski, K; Nijboer, CH | 1 |
| Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y | 1 |
| Kozachik, SL; Page, GG | 1 |
| Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY | 1 |
| Abe, K; Chiba, T; Kambe, T; Kawakami, K; Koizumi, N; Oka, Y; Taguchi, K; Utsunomiya, I | 1 |
| Taguchi, K | 1 |
| Albrecht, PJ; de Carvalho-Barbosa, M; Dougherty, PM; Heijnen, CJ; Kavelaars, A; Li, Y; Zhang, H | 1 |
| Kanaoka, D; Kawabata, A; Kawaishi, Y; Kawakami, E; Kawara, Y; Ohkubo, T; Ozaki, T; Sekiguchi, F; Tomita, S; Tsubota, M; Yoshida, S | 1 |
| Egashira, N; Kaname, T; Kawashiri, T; Shiraishi, H; Tsutsumi, K | 1 |
| Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL | 1 |
| de Santis, V; Duggett, NA; Flatters, SJ; Griffiths, LA; McKenna, OE; Mokori, EB; Yongsanguanchai, N | 1 |
| Ishikura, H; Kamitani, N; Kawabata, A; Kawaishi, Y; Liu, K; Nishibori, M; Nishida, T; Sekiguchi, F; Tsubota, M; Yamanishi, H | 1 |
| Damaj, MI; Donvito, G; Lichtman, AH; Wilkerson, JL | 1 |
| Deng, L; Hohmann, AG; Lee, WH; Makriyannis, A; Xu, Z | 1 |
| Colvin, L; Galley, HF; Lowes, DA; McCormick, B; Torsney, C | 1 |
| Cassidy, RM; Dougherty, PM; Edwards, DD; Harrison, DS; Johansson, CA; Kosturakis, AK; Li, Y; North, RY; Rhines, LD; Tatsui, CE; Zhang, H | 1 |
| Neelakantan, H; Walker, EA; Ward, SJ | 1 |
| Butovsky, O; Duffy, SS; Goldstein, D; Lees, JG; Makker, PG; Moalem-Taylor, G; Park, SB; Perera, CJ; Tonkin, RS | 1 |
| Chen, YH; Chen, YS; Hsu, ST; Hsu, YM; Lin, JH; Yao, CH | 1 |
| Hayashi, S; Ikeda, H; Ikegami, M; Kai, M; Kamei, J; Nakanishi, Y; Sakai, A | 1 |
| Andoh, T; Kobayashi, N; Kuraishi, Y; Uta, D | 1 |
| Alkhlaif, Y; Alsharari, SD; Bagdas, D; Bigbee, JW; Chen, ZJ; Damaj, MI; Del Fabbro, E; Gewirtz, DA; Kyte, SL; Lichtman, AH; Toma, W | 1 |
| Cata, JP; Dougherty, PM; Weng, HR | 1 |
| Egashira, N; Ikegami, Y; Itoh, Y; Kawashiri, T; Oishi, R; Shimazoe, T; Yano, T; Yoshimura, M | 1 |
| Auguet, M; Chabrier, PE; Favre-Guilmard, C | 1 |
| Bennett, GJ; Bordet, T; Pruss, RM; Xiao, WH; Zheng, FY | 1 |
| Cui, Y; Liu, CC; Liu, XG; Lu, N; Xin, WJ; Yang, T; Zhao, ZQ | 1 |
| Kawamata, T; Kiya, T; Namiki, A; Yamakage, M | 1 |
| Boyette-Davis, J; Dougherty, PM; Xin, W; Zhang, H | 1 |
| Bento, AF; Calixto, JB; Costa, R; Dutra, RC; Malinsky, FR; Manjavachi, MN; Motta, EM; Pesquero, JB | 1 |
| Fukushima, N; Kanaoka, D; Kawabata, A; Matsunami, M; Ohkubo, T; Okubo, K; Sekiguchi, F; Takahashi, T; Yamazaki, J; Yoshida, S | 1 |
| Neelakantan, H; Ramirez, MD; Walker, EA; Ward, SJ | 1 |
| Chen, Y; Wang, ZJ; Yang, C | 1 |
| Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y | 1 |
| Egashira, N; Kawashiri, T; Masuguchi, K; Oishi, R; Ushio, S; Yamashita, Y | 1 |
| Barrière, DA; Busserolles, J; Chanteranne, D; Chapuis, L; Chauvin, MA; Dubray, C; Morio, B; Rieusset, J; Salles, J | 1 |
| Bennett, GJ; Xiao, WH; Zheng, H | 1 |
| Bennett, GJ; Xiao, WH | 1 |
| Benemei, S; Creminon, C; Fusi, C; Geppetti, P; Materazzi, S; Nassini, R; Nilius, B; Patacchini, R; Pedretti, P; Prenen, J | 1 |
| Burgos, E; Goicoechea, C; Gómez-Nicola, D; Martín, MI; Nieto-Sampedro, M; Pascual, D | 1 |
| Bie, B; Brown, DL; Cogdell, D; Craig, S; Diaz, P; Hittelman, WN; Hu, J; Naguib, M; Xu, JJ | 1 |
| Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y | 1 |
| Ami, N; Okamoto, K; Oshima, H | 1 |
| Baulies, A; Bura, SA; Ruiz-Medina, J; Valverde, O | 1 |
| Katsuyama, S; Kishikawa, Y; Komatsu, T; Kuwahata, H; Nakamura, H; Sakurada, T; Yagi, T | 1 |
| Isami, K; Kaneko, S; Nakagawa, T; Nakamura, S; Shirakawa, H; Zhao, M | 1 |
| Deng, L; Guindon, J; Hohmann, AG; Makriyannis, A; Thakur, GA; Vemuri, VK; White, FA | 1 |
| Aoki, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Entrena, JM; Nieto, FR; Sánchez-Fernández, C; Tejada, MA; Vela, JM; Zamanillo, D | 1 |
| Abe, K; Chiba, T; Hama, T; Katagiri, N; Kawakami, K; Saduka, M; Taguchi, K; Utsunomiya, I | 1 |
| Kawamata, T; Kiya, T | 1 |
| Hasumi, K; Hirai, Y; Iwasaki, H; Matsui, H; Sekiya, S; Tate, S | 1 |
| Crager, SE; Mogil, JS; Smith, SB | 1 |
| Alessandri-Haber, N; Dina, OA; Levine, JD; Parada, CA; Reichling, DB; Yeh, JJ | 1 |
| Aravindan, N; Cata, JP; Chen, JH; Dougherty, PM; Shaw, AD; Weng, HR | 1 |
| Goicoechea, C; Martín, MI; Pascual, D; Suardíaz, M | 1 |
| Cata, JP; Chen, JH; Dougherty, PM; Weng, HR | 1 |
| Ghilardi, JR; Jimenez-Andrade, JM; Jonas, BM; Koewler, NJ; Mantyh, PW; Peters, CM; Sevcik, MA; Wong, GY | 1 |
| Chavez, RA; Jekich, BM; Johnson, KW; Langer, SJ; Ledeboer, A; Leinwand, LA; Mahoney, JH; Maier, SF; Martin, D; Milligan, ED; Sloane, EM; Watkins, LR | 1 |
| Baeyens, JM; Cendán, CM; Del Pozo, E; Entrena, JM; Nieto, FR; Vela, JM | 1 |
| Alessandri-Haber, N; Dina, OA; Green, PG; Khasar, SG; Levine, JD; Messing, RO | 1 |
| Aono, Y; Arai, T; Hidaka, T; Ieki, M; Kuraishi, Y; Nagira, K; Nakamura, T; Saito, S; Shima, T | 1 |
| Authier, N; Coudore, F; Eschalier, A; Fialip, J; Gillet, JP | 1 |
| Bennett, GJ; Clark, US; Mannes, AJ; Polomano, RC | 1 |
| Chen, X; Dina, OA; Levine, JD; Reichling, D | 1 |
5 review(s) available for paclitaxel and Allodynia
| Article | Year |
|---|---|
Goshajinkigan attenuates paclitaxel-induced neuropathic pain via cortical astrocytes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Somatosensory Cortex | 2021 |
Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; Neuralgia; Paclitaxel | 2022 |
Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies.
Topics: Animals; Antineoplastic Agents; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cisplatin; Disease Models, Animal; Endocannabinoids; Evaluation Studies as Topic; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Rats; Signal Transduction | 2017 |
[Peripheral neuropathy induced by anticancer drugs].
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cold Temperature; Drugs, Chinese Herbal; Humans; Hyperalgesia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nervous System Diseases; Pyrazines; Sensation Disorders; Vincristine; Vitamin B 12 | 2013 |
[Role of Transient Receptor Potential Channels in Paclitaxel- and Oxaliplatin-induced Peripheral Neuropathy].
Topics: Acute Disease; Animals; Antineoplastic Agents; Calcium Channels; Ganglia, Spinal; Gene Expression; Humans; Hyperalgesia; Molecular Targeted Therapy; Nerve Tissue Proteins; Organoplatinum Compounds; Oxaliplatin; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Peripheral Nervous System Diseases; Rats; Spinal Cord Dorsal Horn; Substance P; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels; Up-Regulation | 2016 |
1 trial(s) available for paclitaxel and Allodynia
| Article | Year |
|---|---|
Pharmacological Modulation of the Mitochondrial Electron Transport Chain in Paclitaxel-Induced Painful Peripheral Neuropathy.
Topics: Animals; Antimycin A; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electron Transport; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Hyperalgesia; Male; Motor Activity; Paclitaxel; Pain; Pain Measurement; Peripheral Nervous System Diseases; Psychomotor Disorders; Rats; Rats, Sprague-Dawley; Rotenone; Single-Blind Method; Time Factors | 2015 |
194 other study(ies) available for paclitaxel and Allodynia
| Article | Year |
|---|---|
Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain.
Topics: Animals; Capsaicin; Chronic Pain; Hyperalgesia; Mice; Microtubules; Neuralgia; Paclitaxel; Trigeminal Neuralgia; TRPV Cation Channels; Tubulin | 2022 |
Anti-neuropathic pain activity of a cationic palladium (II) dithiocarbamate by suppressing the inflammatory mediators in paclitaxel-induced neuropathic pain model.
Topics: Analgesics; Animals; Antioxidants; Cytokines; Female; Hyperalgesia; Inflammation; Inflammation Mediators; Models, Animal; Neuralgia; Nitric Oxide Synthase Type II; Paclitaxel; Palladium; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2021 |
The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors.
Topics: Animals; Antineoplastic Agents; Cannabidiol; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Mice; Neuralgia; Paclitaxel; PPAR gamma | 2022 |
Second messengers mediating high-molecular-weight hyaluronan-induced antihyperalgesia in rats with chemotherapy-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Female; Hyaluronic Acid; Hyperalgesia; Male; Neuralgia; Oxaliplatin; Paclitaxel; Rats; Receptors, G-Protein-Coupled; RNA, Messenger; Second Messenger Systems; Type C Phospholipases | 2022 |
A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse.
Topics: Animals; Antineoplastic Agents; Cannabinoids; Cytokines; Hyperalgesia; Mice; Mice, Knockout; Neuralgia; Paclitaxel; Purines; Pyrans; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2022 |
Dual PI3Kδ/γ Inhibitor Duvelisib Prevents Development of Neuropathic Pain in Model of Paclitaxel-Induced Peripheral Neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Hyperalgesia; Isoquinolines; Male; Mice; Neuralgia; Paclitaxel; Pain; Peripheral Nervous System Diseases; Phosphatidylinositol 3-Kinases; Purines; Rats | 2022 |
Effect of Cliothosa aurivilli on Paclitaxel-induced Peripheral Neuropathy in Experimental Animals.
Topics: Animals; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Pain Measurement; Porifera | 2022 |
Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Calcitonin Gene-Related Peptide; Duloxetine Hydrochloride; Ganglia, Spinal; Hyperalgesia; Neuralgia; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Spinal Cord Dorsal Horn; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2022 |
The 7-Hydroxyflavone attenuates chemotherapy-induced neuropathic pain by targeting inflammatory pathway.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cyclooxygenase 2; Cytokines; Edema; Flavonoids; Hyperalgesia; Inflammation Mediators; Mice; Neuralgia; NF-kappa B; Paclitaxel; Rats; Rats, Sprague-Dawley; Vincristine | 2022 |
TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K
Topics: Animals; Dioxygenases; Ganglia, Spinal; Hyperalgesia; Male; Neuralgia; Paclitaxel; Potassium Channels; Rats; Sensory Receptor Cells | 2022 |
Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel.
Topics: Animals; Antineoplastic Agents; Humans; Hyperalgesia; Mice; Mice, Inbred C57BL; Paclitaxel; Peripheral Nervous System Diseases | 2022 |
Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model.
Topics: Analgesics; Animals; gamma-Aminobutyric Acid; Hyperalgesia; Mice; Monoamine Oxidase Inhibitors; Neuralgia; Paclitaxel; Reactive Oxygen Species; Spinal Cord | 2022 |
Systemic, Intrathecal, and Intracerebroventricular Antihyperalgesic Effects of the Calcium Channel Blocker CTK 01512-2 Toxin in Persistent Pain Models.
Topics: Animals; Calcium Channel Blockers; Chronic Pain; Disease Models, Animal; Humans; Hyperalgesia; omega-Conotoxins; Paclitaxel; Spider Venoms | 2022 |
Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions.
Topics: Animals; Antineoplastic Agents; Hyperalgesia; Mice; Molecular Docking Simulation; Paclitaxel; Peripheral Nervous System Diseases; Rats; Receptor, Anaphylatoxin C5a | 2022 |
Upregulation of neuronal progranulin mediates the antinociceptive effect of trimetazidine in paclitaxel-induced peripheral neuropathy: Role of ERK1/2 signaling.
Topics: Analgesics; Animals; Axons; Humans; Hyperalgesia; MAP Kinase Signaling System; Neuralgia; Paclitaxel; Progranulins; Rats; Sciatic Nerve; Trimetazidine; Up-Regulation | 2022 |
Notch signaling activation contributes to paclitaxel-induced neuropathic pain via activation of A1 astrocytes.
Topics: Animals; Astrocytes; Hyperalgesia; Neuralgia; Paclitaxel; Platelet Aggregation Inhibitors; Rats; Signal Transduction; Spinal Cord | 2022 |
Shaoyao Gancao Decoction Ameliorates Paclitaxel-Induced Peripheral Neuropathy via Suppressing TRPV1 and TLR4 Signaling Expression in Rats.
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Hyperalgesia; Myeloid Differentiation Factor 88; Paclitaxel; Peripheral Nervous System Diseases; Rats; Toll-Like Receptor 4; TRPV Cation Channels | 2022 |
Bone marrow-derived mesenchymal stem cells alleviate paclitaxel-induced mechanical allodynia in rats.
Topics: Animals; Bone Marrow; Cytokines; Hyperalgesia; Mesenchymal Stem Cells; Paclitaxel; Rats; Tumor Necrosis Factor-alpha | 2022 |
Meteorin Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Mice.
Topics: Analgesics; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Female; Humans; Hyperalgesia; Male; Mice; Neuralgia; Paclitaxel; Quality of Life | 2023 |
Protective effect of a mitochondria-targeting peptide against paclitaxel-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Hyperalgesia; Mice; Mitochondria; Paclitaxel; Peptides; Peripheral Nervous System Diseases; Quality of Life | 2023 |
Khellin as a selective monoamine oxidase B inhibitor ameliorated paclitaxel-induced peripheral neuropathy in mice.
Topics: Animals; Hyperalgesia; Khellin; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Paclitaxel; Peripheral Nervous System Diseases | 2023 |
Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain.
Topics: Animals; Antineoplastic Agents; Epigenesis, Genetic; Ganglia, Spinal; Histones; Humans; Hyperalgesia; Male; Neuralgia; Neurons; NIMA-Related Kinases; Paclitaxel; Phosphates; Quality of Life; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2023 |
Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice.
Topics: Animals; Antineoplastic Agents; Female; Ganglia, Spinal; Humans; Hyperalgesia; Inducible T-Cell Co-Stimulator Protein; Interleukin-10; Mice; Neuralgia; Paclitaxel | 2023 |
Comparative Transcriptome of Dorsal Root Ganglia Reveals Distinct Etiologies of Paclitaxel- and Oxaliplatin-induced Peripheral Neuropathy in Rats.
Topics: Animals; Antineoplastic Agents; Ganglia, Spinal; Hyperalgesia; Oxaliplatin; Paclitaxel; Peripheral Nervous System Diseases; Rats; Transcriptome | 2023 |
Kinin B
Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Bradykinin; Cancer Pain; Hyperalgesia; Mice; Neoplasms; Paclitaxel; Pain; Receptor, Bradykinin B1; Receptor, Bradykinin B2 | 2023 |
Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway.
Topics: Animals; Antineoplastic Agents; Hyperalgesia; Hyperbaric Oxygenation; Lipopolysaccharides; Myeloid Differentiation Factor 88; NF-kappa B; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4 | 2023 |
Daidzein attenuated paclitaxel-induced neuropathic pain via the down-regulation of TRPV1/P2Y and up-regulation of Nrf2/HO-1 signaling.
Topics: Antineoplastic Agents; Antioxidants; Down-Regulation; Heme Oxygenase-1; Humans; Hyperalgesia; Inflammation Mediators; Isoflavones; Neuralgia; NF-E2-Related Factor 2; Oxidative Stress; Paclitaxel; TRPV Cation Channels; Up-Regulation | 2023 |
Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes.
Topics: Analgesics; Animals; Antineoplastic Agents; Exosomes; Female; Humans; Hyperalgesia; Male; Mice; Neuralgia; Paclitaxel; Rats; Spinal Cord | 2023 |
Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice.
Topics: Analgesics; Animals; Duloxetine Hydrochloride; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Pain Measurement; Rosuvastatin Calcium | 2023 |
Trimethoxyflavanone relieves Paclitaxel-induced neuropathic pain via inhibiting expression and activation of P2X7 and production of CGRP in mice.
Topics: Animals; Antineoplastic Agents; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Hyperalgesia; Mice; Molecular Docking Simulation; Neuralgia; Paclitaxel | 2023 |
Protease-Activated Receptor 2 (PAR2) Expressed in Sensory Neurons Contributes to Signs of Pain and Neuropathy in Paclitaxel Treated Mice.
Topics: Animals; Female; Ganglia, Spinal; Gliosis; Hyperalgesia; Male; Mice; Mice, Knockout; Paclitaxel; Pain; Peripheral Nervous System Diseases; Receptor, PAR-2; Sensory Receptor Cells | 2023 |
Topical coapplication of hyaluronan with transdermal drug delivery enhancers attenuates inflammatory and neuropathic pain.
Topics: Animals; Dimethyl Sulfoxide; Female; Hyaluronic Acid; Hyperalgesia; Male; Neuralgia; Paclitaxel; Protamines; Rats; Rats, Sprague-Dawley | 2023 |
Intrathecal rapamycin attenuates the mechanical hyperalgesia of paclitaxel-induced peripheral neuropathy in mice.
Topics: Animals; Antineoplastic Agents; Hyperalgesia; Mice; Paclitaxel; Peripheral Nervous System Diseases; Sirolimus | 2023 |
Short-chain fatty acid, butyrate prevents morphine-and paclitaxel-induced nociceptive hypersensitivity.
Topics: Analgesics, Opioid; Animals; Butyrates; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Mice; Morphine; Nociception; Paclitaxel; Quality of Life | 2023 |
Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats.
Topics: Animals; Complement System Proteins; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Potassium Iodide; Rats; Rats, Sprague-Dawley; Receptors, Complement; TRPV Cation Channels | 2023 |
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1.
Topics: Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Chemokine CXCL12; Female; Hyperalgesia; Male; Mice; Paclitaxel; Tumor Necrosis Factor-alpha | 2019 |
Role of transient receptor potential ankyrin 1 (TRPA1) on nociception caused by a murine model of breast carcinoma.
Topics: Acetanilides; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cancer Pain; Cell Line, Tumor; Female; Hydrogen Peroxide; Hyperalgesia; Mammary Neoplasms, Experimental; Mice, Inbred BALB C; NADPH Oxidases; Nociception; Oximes; Paclitaxel; Purines; Sciatic Nerve; Skin; Superoxide Dismutase; Thioctic Acid; TRPA1 Cation Channel | 2020 |
Comparison of chemotherapy effects on mechanical sensitivity and food-maintained operant responding in male and female rats.
Topics: Animals; Antineoplastic Agents; Body Weight; Bortezomib; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Morphine; Oxaliplatin; Paclitaxel; Rats; Vincristine | 2020 |
RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Conotoxins; Humans; Hyperalgesia; Male; Neuralgia; Nicotinic Antagonists; Paclitaxel; Rats; Rats, Sprague-Dawley | 2019 |
Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress.
Topics: Animals; Endocrine System; Female; Hyperalgesia; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stress, Physiological | 2020 |
Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy.
Topics: Animals; Ganglia, Spinal; Humans; Hyperalgesia; Interleukins; Mice; Paclitaxel; Peripheral Nervous System Diseases | 2020 |
Upregulation of TRPC6 Mediated by PAX6 Hypomethylation Is Involved in the Mechanical Allodynia Induced by Chemotherapeutics in Dorsal Root Ganglion.
Topics: Animals; Antineoplastic Agents; Bortezomib; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Ganglia, Spinal; Gene Expression; Hyperalgesia; Male; Neuralgia; Oxaliplatin; Paclitaxel; PAX6 Transcription Factor; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Up-Regulation | 2020 |
Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Disease Models, Animal; Female; Hyperalgesia; Inflammation; Male; Mice; Paclitaxel; Sympathectomy | 2020 |
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Topics: Analgesics; Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hyperalgesia; Male; Neuralgia; NF-E2-Related Factor 2; Paclitaxel; Pain Perception; Pain Threshold; PPAR gamma; Rats, Sprague-Dawley; Rosiglitazone; Signal Transduction; Spinal Cord; Up-Regulation | 2020 |
Paclitaxel Induces Upregulation of Transient Receptor Potential Vanilloid 1 Expression in the Rat Spinal Cord.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Paclitaxel; Rats; RNA, Small Interfering; Spinal Cord; TRPV Cation Channels; Up-Regulation | 2020 |
JTC-801 alleviates mechanical allodynia in paclitaxel-induced neuropathic pain through the PI3K/Akt pathway.
Topics: Aminoquinolines; Analgesics; Animals; Behavior, Animal; Benzamides; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inflammation Mediators; Interleukin-1beta; Male; Narcotic Antagonists; Neuralgia; Nociceptin Receptor; Paclitaxel; Pain Threshold; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Opioid; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
Peripheral deficiency and antiallodynic effects of 2-arachidonoyl glycerol in a mouse model of paclitaxel-induced neuropathic pain.
Topics: Analgesics; Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Agonists; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Hyperalgesia; Mice, Inbred BALB C; Monoacylglycerol Lipases; Neuralgia; Paclitaxel; Piperidines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Skin | 2020 |
Iridoids isolated from Viticis Fructus inhibit paclitaxel-induced mechanical allodynia in mice.
Topics: Animals; Disease Models, Animal; Drug Interactions; Hyperalgesia; Iridoids; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Plant Extracts; Vitex | 2021 |
The cannabinoid CB
Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Conditioning, Operant; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Morphine Dependence; Neuralgia; Nociception; Paclitaxel; Purines; Pyrans; Receptor, Cannabinoid, CB2; Reward; Substance Withdrawal Syndrome | 2020 |
PINK1 alleviates thermal hypersensitivity in a paclitaxel-induced Drosophila model of peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Drosophila; Drosophila Proteins; Gene Expression; Gene Knockdown Techniques; Hyperalgesia; Hyperesthesia; Paclitaxel; Peripheral Nervous System Diseases; Protein Serine-Threonine Kinases; Sensory Receptor Cells | 2020 |
Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo.
Topics: Animals; beta Catenin; Blotting, Western; Ganglia, Spinal; Humans; Hyperalgesia; Male; Mice; Mice, Transgenic; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Wnt Proteins; Wnt3A Protein | 2021 |
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Chronic Pain; Disease Models, Animal; Female; Freund's Adjuvant; Genotype; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Neuralgia; Nociceptive Pain; Paclitaxel; Peripheral Nerve Injuries; Running; Sex Factors | 2021 |
Involvement of TACAN, a Mechanotransducing Ion Channel, in Inflammatory But Not Neuropathic Hyperalgesia in the Rat.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inflammation; Ion Channels; Male; Mechanotransduction, Cellular; Neuralgia; Oxaliplatin; Paclitaxel; Pain Threshold; Rats; Rats, Sprague-Dawley | 2021 |
Human Intravenous Immunoglobulin Alleviates Neuropathic Symptoms in a Rat Model of Paclitaxel-Induced Peripheral Neurotoxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Biomarkers; Disease Models, Animal; Disease Susceptibility; Humans; Hyperalgesia; Immunoglobulins, Intravenous; Macrophages; Neurotoxicity Syndromes; Paclitaxel; Peripheral Nervous System Diseases; Rats; Treatment Outcome | 2021 |
Analgesic Effects of Sokeikakketsuto on Chemotherapy-Induced Mechanical Allodynia and Cold Hyperalgesia in Rats.
Topics: Analgesics; Animals; Antineoplastic Agents; Bortezomib; Cold Temperature; Disease Models, Animal; Drugs, Chinese Herbal; Duloxetine Hydrochloride; Humans; Hyperalgesia; Male; Medicine, Kampo; Oxaliplatin; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley | 2021 |
DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.
Topics: Animals; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Gene Knockdown Techniques; Hyperalgesia; Male; Matrix Metalloproteinase 2; Neuralgia; Paclitaxel; Promoter Regions, Genetic; Rats, Sprague-Dawley; RNA, Small Interfering; Spinal Cord Dorsal Horn; Sumoylation; Up-Regulation | 2021 |
Cilostazol is an effective causal therapy for preventing paclitaxel-induced peripheral neuropathy by suppression of Schwann cell dedifferentiation.
Topics: Animals; Blood Proteins; Breast Neoplasms; Cell Dedifferentiation; Cell Line, Tumor; Cilostazol; Demyelinating Diseases; Female; Galectins; Ganglia, Spinal; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Schwann Cells; Sciatic Nerve | 2021 |
Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model.
Topics: Animals; Benzopyrans; Butyrates; Disease Models, Animal; Enzyme Activators; Humans; Hyperalgesia; Mice; Neuralgia; Paclitaxel | 2021 |
Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Eosinophils; Escape Reaction; Female; Hyperalgesia; Leukocyte Count; Locomotion; NAD; Neutrophils; Niacinamide; Nociception; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors | 2017 |
Prophylactic Administration of Aucubin Inhibits Paclitaxel-Induced Mechanical Allodynia via the Inhibition of Endoplasmic Reticulum Stress in Peripheral Schwann Cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; Endoplasmic Reticulum Stress; Hyperalgesia; Iridoid Glucosides; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Posterior Horn Cells; Pre-Exposure Prophylaxis; Rats; Schwann Cells | 2017 |
Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.
Topics: Action Potentials; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Armadillo Domain Proteins; Cytoskeletal Proteins; Diet, High-Fat; Disease Models, Animal; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Conduction; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Reaction Time; Sural Nerve | 2017 |
Single and combined effects of Δ
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cannabidiol; Disease Models, Animal; Dronabinol; Drug Therapy, Combination; Hyperalgesia; Male; Mice, Inbred C57BL; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Vincristine | 2017 |
Involvement of Charcot-Marie-Tooth disease gene mitofusin 2 expression in paclitaxel-induced mechanical allodynia in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Charcot-Marie-Tooth Disease; Disease Models, Animal; GTP Phosphohydrolases; Hyperalgesia; Male; Membrane Proteins; Mitochondrial Proteins; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley | 2017 |
Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats.
Topics: Analgesics; Animals; Asteraceae; Ethanol; Hyperalgesia; Injections, Intraperitoneal; Neuralgia; Paclitaxel; Plant Extracts; Pregabalin; Rats, Sprague-Dawley | 2017 |
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cannabinoid Receptor Modulators; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Indoles; Male; Neuralgia; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Piperidines; Polycyclic Sesquiterpenes; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sesquiterpenes; Spinal Cord | 2017 |
Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats.
Topics: Administration, Oral; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Hyperalgesia; Injections, Intra-Articular; Iodoacetic Acid; Male; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Palmitic Acids; Phytotherapy; Plant Extracts; Plant Roots; Polyunsaturated Alkamides; Postural Balance; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatica; Water | 2017 |
Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Female; Humans; Hyperalgesia; Male; Melatonin; Mitochondria; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley | 2017 |
Electroacupuncture alleviates chemotherapy-induced pain through inhibiting phosphorylation of spinal CaMKII in rats.
Topics: Acupuncture Points; Animals; Antineoplastic Agents, Phytogenic; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Electroacupuncture; Hyperalgesia; Male; Neuralgia; Paclitaxel; Phosphorylation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2018 |
Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Hyperalgesia; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Nicotine; Paclitaxel; Peripheral Nervous System Diseases; Receptors, Cholinergic; Taxoids | 2018 |
AKAP150 involved in paclitaxel-induced neuropathic pain via inhibiting CN/NFAT2 pathway and downregulating IL-4.
Topics: A Kinase Anchor Proteins; Animals; Calcineurin; Cytokines; Down-Regulation; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Interleukin-4; Male; Neuralgia; NFATC Transcription Factors; Paclitaxel; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation | 2018 |
Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal α₂-Adrenergic Receptor.
Topics: Acupuncture Therapy; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bee Venoms; Hyperalgesia; Idazoxan; Male; Melitten; Neuralgia; Paclitaxel; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord | 2017 |
DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.
Topics: Action Potentials; Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Female; Ganglia, Spinal; Humans; Hyperalgesia; Male; NAV1.7 Voltage-Gated Sodium Channel; Neuralgia; Paclitaxel; Patch-Clamp Techniques; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spider Venoms; Up-Regulation | 2018 |
OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.
Topics: Animals; Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Genotype; HEK293 Cells; Humans; Hyperalgesia; Inhibitory Concentration 50; Liver-Specific Organic Anion Transporter 1; MCF-7 Cells; Mice; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Organic Anion Transporters; Paclitaxel; Peripheral Nervous System Diseases; Phenotype; Pyrimidines | 2018 |
Repeated Morphine Produces Sensitization to Reward and Tolerance to Antiallodynia in Male and Female Rats with Chemotherapy-Induced Neuropathy.
Topics: Animals; Antineoplastic Agents; Female; Hyperalgesia; Male; Morphine; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Reward; Time Factors | 2018 |
Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Astrocytes; Disease Models, Animal; Female; Ganglia, Spinal; Guanine Nucleotide Exchange Factors; Hydrazones; Hyperalgesia; Isoxazoles; Male; Mice; Mice, Knockout; Nerve Fibers; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Spinal Cord | 2018 |
Nicorandil inhibits mechanical allodynia induced by paclitaxel by activating opioidergic and serotonergic mechanisms.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Motor Activity; Nicorandil; Opioid Peptides; Paclitaxel; Sciatic Nerve; Serotonin | 2018 |
Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.
Topics: Animals; Complement System Proteins; Disease Models, Animal; Hyperalgesia; Immunity, Innate; Nerve Fibers; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Quality of Life; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 2018 |
Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Hyperalgesia; Male; Motor Activity; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Psychomotor Performance; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors | 2018 |
Targeting Axon Integrity to Prevent Chemotherapy-Induced Peripheral Neuropathy.
Topics: Actin Depolymerizing Factors; Action Potentials; Animals; Antineoplastic Agents; Apoptosis; Axons; Caspase 3; Ganglia, Spinal; HSP27 Heat-Shock Proteins; Humans; Hyperalgesia; Male; Mice, Transgenic; Mitochondria; Mitochondrial Swelling; Myelin Sheath; Nerve Degeneration; Nerve Fibers; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases; rhoA GTP-Binding Protein; Signal Transduction | 2019 |
Pregabalin and lacosamide ameliorate paclitaxel-induced peripheral neuropathy via inhibition of JAK/STAT signaling pathway and Notch-1 receptor.
Topics: Animals; Hyperalgesia; Lacosamide; Male; Neuralgia; Paclitaxel; Pregabalin; Rats, Wistar; Receptors, Notch; Sciatic Nerve; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2018 |
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk.
Topics: Acetylcysteine; Animals; Antibodies; Cells, Cultured; Clodronic Acid; Coculture Techniques; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Imidazoles; Macrophages; Male; Membrane Proteins; Mice; Minocycline; Neurons; p300-CBP Transcription Factors; Paclitaxel; Peripheral Nervous System Diseases; Phosphoproteins; Phosphorylation; Proline; Pyridines; Pyruvates; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, CXCR4; Recombinant Proteins; Sciatic Nerve; Thiocarbamates; Thrombomodulin; Up-Regulation | 2018 |
Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats.
Topics: Amphibian Venoms; Animals; Astrocytes; Cytokines; Hyperalgesia; Inflammation; Male; Neuralgia; Neuroprotective Agents; Paclitaxel; Rats, Sprague-Dawley; Spinal Cord; TRPV Cation Channels; Up-Regulation | 2018 |
Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Gelsemium; Hyperalgesia; Male; Paclitaxel; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Plant Extracts; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2018 |
Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Cell Line, Tumor; Humans; Hyperalgesia; Male; Mammary Neoplasms, Experimental; MAP Kinase Signaling System; Mice, Inbred BALB C; Paclitaxel; Peripheral Nervous System Diseases; Protein Kinase C; Tamoxifen; Vincristine | 2018 |
A light-gated potassium channel for sustained neuronal inhibition.
Topics: Action Potentials; Animals; Female; Hyperalgesia; Light; Male; Mice, Inbred C57BL; Neurons; Optogenetics; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Zebrafish | 2018 |
Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Agonists; Central Nervous System Sensitization; Epigenesis, Genetic; Hyperalgesia; Inflammation; Male; Microglia; Neuralgia; Paclitaxel; Piperidines; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Spinal Cord Dorsal Horn | 2019 |
Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy.
Topics: Animals; Capsaicin; Excitatory Postsynaptic Potentials; Hyperalgesia; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oncogene Protein v-akt; Paclitaxel; Peptide Fragments; Phosphatidylinositol 3-Kinases; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Spinal Cord; Toll-Like Receptor 4; Transient Receptor Potential Channels; TRPV Cation Channels | 2019 |
Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Immunologic Factors; Male; Matrix Metalloproteinase 9; Mice; Neuralgia; Neurons; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases | 2019 |
Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal.
Topics: Analgesics, Opioid; Animals; Cannabinoids; Cell Line; Chromones; Dronabinol; Drug Tolerance; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Neuralgia; Paclitaxel; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction | 2019 |
Mesenchymal stem cells therapy enhances the efficacy of pregabalin and prevents its motor impairment in paclitaxel-induced neuropathy in rats: Role of Notch1 receptor and JAK/STAT signaling pathway.
Topics: Acetone; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Caspase 3; Cell- and Tissue-Based Therapy; Disease Models, Animal; Hyperalgesia; Interleukin-6; Janus Kinases; Male; Mesenchymal Stem Cells; Motor Disorders; Nerve Growth Factor; Paclitaxel; Pregabalin; Rats; Rats, Wistar; Receptor, Notch1; Rotarod Performance Test; Sciatic Neuropathy; STAT Transcription Factors; Time Factors; Tumor Necrosis Factor-alpha | 2019 |
Polyester Nanoparticle Encapsulation Mitigates Paclitaxel-Induced Peripheral Neuropathy.
Topics: Animals; Ganglia, Spinal; Hyperalgesia; Nanoparticles; Neuralgia; Paclitaxel; Polyesters; Rats, Sprague-Dawley | 2019 |
Circulating microRNA and automated motion analysis as novel methods of assessing chemotherapy-induced peripheral neuropathy in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Automation; Behavior, Animal; Biomarkers; Circulating MicroRNA; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Movement; Nerve Degeneration; Paclitaxel; Peripheral Nervous System Diseases; Sciatic Nerve | 2019 |
DNMT3a-triggered downregulation of K
Topics: Animals; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Down-Regulation; Ganglia, Spinal; Humans; Hyperalgesia; Male; Mice, Knockout; Neuralgia; Paclitaxel; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; RNA Interference; Sensory Receptor Cells | 2019 |
Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice.
Topics: Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Cisplatin; Disease Models, Animal; Female; Hyperalgesia; Male; Mice, Transgenic; Paclitaxel; Pain; Peripheral Nervous System Diseases | 2019 |
Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor
Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Benzamides; Benzoxazines; Brain; Cannabinoids; Carbamates; Cell Line, Tumor; Cell Survival; Drug Synergism; Drug Tolerance; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuralgia; Paclitaxel; Substance-Related Disorders | 2019 |
Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.
Topics: Aconitine; Aconitum; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Hyperalgesia; Male; Mice; Neuralgia; Paclitaxel; Peripheral Nerve Injuries; Plant Roots; Rats, Wistar; Sciatic Nerve | 2019 |
Losartan, an Angiotensin II Type 1 Receptor Antagonist, Alleviates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain by Inhibiting Inflammatory Cytokines in the Dorsal Root Ganglia.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cytokines; Disease Models, Animal; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Hyperalgesia; Hypnotics and Sedatives; Inflammation Mediators; Losartan; Male; Neuralgia; Neurons; NF-kappa B; Paclitaxel; Phosphorylation; Rats, Sprague-Dawley | 2019 |
Knockdown siRNA Targeting the Mitochondrial Sodium-Calcium Exchanger-1 Inhibits the Protective Effects of Two Cannabinoids Against Acute Paclitaxel Toxicity.
Topics: Animals; Cannabidiol; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Neurons; Neuroprotective Agents; Paclitaxel; Rats; RNA Interference; Sodium-Calcium Exchanger | 2019 |
Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula "Goshajinkigan".
Topics: Animals; Drugs, Chinese Herbal; Hyperalgesia; Iridoid Glucosides; Iridoids; Lactones; Male; Medicine, Kampo; Mice; Mice, Inbred C57BL; Paclitaxel; Peripheral Nervous System Diseases; Plant Extracts; Plantago | 2019 |
Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice.
Topics: Animals; Antineoplastic Agents; Female; Hyperalgesia; Macrophages; Male; Mice; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Toll-Like Receptor 9 | 2019 |
Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels.
Topics: Animals; Chemokine CXCL1; Ganglia, Spinal; Hyperalgesia; KATP Channels; Male; Mice; Neuralgia; Niacinamide; Paclitaxel; Riboflavin; Thalamus; Thiamine; Tumor Necrosis Factor-alpha; Vitamin B Complex | 2020 |
Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.
Topics: Animals; Hyperalgesia; Male; Paclitaxel; Pain Threshold; Physical Stimulation; Polyneuropathies; Rats; Rats, Sprague-Dawley; Touch; Ubiquinone | 2013 |
Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia.
Topics: Animals; Chemokine CCL2; Cold Temperature; Hyperalgesia; Male; Mice; Microglia; Minocycline; Neuralgia; Paclitaxel; Receptors, CCR2; Spinal Cord | 2013 |
Effects of repeated milnacipran and fluvoxamine treatment on mechanical allodynia in a mouse paclitaxel-induced neuropathic pain model.
Topics: Animals; Cyclopropanes; Disease Models, Animal; Fluvoxamine; Hyperalgesia; Male; Mice; Milnacipran; Neuralgia; Paclitaxel | 2013 |
Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion.
Topics: Animals; Ganglia, Spinal; Hyperalgesia; Male; Neurons; Paclitaxel; Pain Threshold; Rats; Rats, Wistar; Ruthenium Red; TRPV Cation Channels | 2013 |
Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Axons; Boronic Acids; Bortezomib; Energy Metabolism; Hyperalgesia; Male; Mitochondria; Neoplasm Transplantation; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nerves; Peroxynitrous Acid; Physical Stimulation; Protein Processing, Post-Translational; Pyrazines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Superoxide Dismutase | 2013 |
Neurosteroid 3α-androstanediol efficiently counteracts paclitaxel-induced peripheral neuropathy and painful symptoms.
Topics: Action Potentials; Androstane-3,17-diol; Animals; Antineoplastic Agents, Phytogenic; Hyperalgesia; Male; Nerve Fibers; Neural Conduction; Neuralgia; Neuroprotective Agents; Paclitaxel; Pain; Pain Measurement; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley | 2013 |
STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice.
Topics: Adenocarcinoma; Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Drug Administration Schedule; Drug Dosage Calculations; Estrenes; Female; Humans; Hyperalgesia; Lung Neoplasms; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Paclitaxel; Peripheral Nervous System Diseases; Rats; Survival Analysis; Transplantation, Heterologous | 2013 |
Spinal gene expression profiling and pathways analysis of a CB2 agonist (MDA7)-targeted prevention of paclitaxel-induced neuropathy.
Topics: Animals; Benzofurans; Gene Expression Profiling; Hyperalgesia; Lumbosacral Region; Mice; Paclitaxel; Pain Threshold; Piperidines; Rats; Receptor, Cannabinoid, CB2; Signal Transduction; Spinal Cord | 2014 |
The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanes; Female; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley | 2013 |
Paclitaxel-induced hyperalgesia modulates negative affective component of pain and NR1 receptor expression in the frontal cortex in rats.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Conditioning, Operant; Formaldehyde; Frontal Lobe; Hot Temperature; Hyperalgesia; Male; Nociception; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2014 |
Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain.
Topics: Analysis of Variance; Animals; Anti-Retroviral Agents; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Hyperalgesia; Imidazoles; Male; Neuralgia; Osteoarthritis, Knee; Paclitaxel; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vincristine; Weight-Bearing | 2014 |
Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Motor Activity; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord | 2014 |
Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chemokine CCL2; Chromones; Disease Models, Animal; Dronabinol; Female; Hyperalgesia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Paclitaxel; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; Tumor Necrosis Factor-alpha | 2015 |
The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.
Topics: Animals; Cisplatin; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Metformin; Mice, Inbred C57BL; Nerve Fibers; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Protective Agents | 2014 |
Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia.
Topics: Animals; Antibodies; Antineoplastic Agents, Phytogenic; Chemokine CCL3; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, CCR5; Receptors, Purinergic P2X7; RNA, Messenger; Spinal Cord; Time Factors | 2014 |
Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl/6 mice.
Topics: Action Potentials; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Behavior, Animal; Boronic Acids; Bortezomib; Cisplatin; Electrophysiology; Gait; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Polyneuropathies; Pyrazines; Vincristine | 2014 |
The prophylactic effects of a traditional Japanese medicine, goshajinkigan, on paclitaxel-induced peripheral neuropathy and its mechanism of action.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cells, Cultured; Disease Models, Animal; Drug Administration Schedule; Drugs, Chinese Herbal; Female; Ganglia, Spinal; Gene Expression Profiling; Gene Expression Regulation; Hyperalgesia; Mice; Mice, Transgenic; Mitochondria; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Inbred F344; Sensory Receptor Cells; Time Factors; TRPV Cation Channels | 2014 |
A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Hyperalgesia; Male; NADP; Neuralgia; Neuroglia; NF-kappa B; Oxidation-Reduction; Paclitaxel; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha | 2014 |
Paclitaxel-induced hyposensitivity to nociceptive chemical stimulation in mice can be prevented by treatment with minocycline.
Topics: Animals; Breast Neoplasms; Female; Formaldehyde; Humans; Hyperalgesia; Mice; Minocycline; Nociception; Paclitaxel; Peripheral Nervous System Diseases | 2014 |
Up-regulation of CX3CL1 via Nuclear Factor-κB-dependent Histone Acetylation Is Involved in Paclitaxel-induced Peripheral Neuropathy.
Topics: Acetylation; Animals; Antineoplastic Agents, Phytogenic; Chemokine CX3CL1; Cytokines; Histones; Hyperalgesia; Male; NF-kappa B; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Spinal Cord; Thiocarbamates; Transcription Factor RelA | 2015 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2015 |
Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents, Phytogenic; Cell Count; Cell Transplantation; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Paclitaxel; Pain Measurement; Pain Threshold; Spinal Cord; Vesicular Inhibitory Amino Acid Transport Proteins | 2015 |
Urinary N telopeptide levels in predicting the anti-nociceptive responses of zoledronic acid and paclitaxel in a rat model of bone metastases.
Topics: Acid Sensing Ion Channels; Analgesics; Animals; Biomarkers; Bone Neoplasms; Cell Line, Tumor; Collagen Type I; Diphosphonates; Drug Evaluation, Preclinical; Female; Ganglia, Spinal; Hyperalgesia; Imidazoles; Neoplasm Transplantation; Osteoclasts; Paclitaxel; Pain; Peptides; Proto-Oncogene Proteins c-fos; Rats, Wistar; Spinal Cord; Zoledronic Acid | 2015 |
Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
Topics: Animals; Female; Hyperalgesia; Indomethacin; Male; Mice; Mice, Inbred BALB C; Minocycline; Paclitaxel; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2015 |
Possible involvement of the Sigma-1 receptor chaperone in chemotherapeutic-induced neuropathic pain.
Topics: Animals; Anisoles; Antineoplastic Agents; Blotting, Western; CHO Cells; Cricetulus; Hyperalgesia; Male; Microscopy, Fluorescence; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Piperazines; Propylamines; Rats, Sprague-Dawley; Receptors, sigma; Sensory System Agents; Sigma-1 Receptor; Spinal Cord; Touch; Transfection | 2015 |
Bulleyaconitine A depresses neuropathic pain and potentiation at C-fiber synapses in spinal dorsal horn induced by paclitaxel in rats.
Topics: Aconitine; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Hyperalgesia; In Vitro Techniques; Male; Nerve Fibers, Unmyelinated; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Synaptic Potentials; Time Factors | 2015 |
The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcium; Excitatory Postsynaptic Potentials; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Pain Measurement; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Signal Transduction; Spinal Cord; Toll-Like Receptor 4; TRPV Cation Channels | 2015 |
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Hyperalgesia; Injections, Spinal; Male; Neuralgia; Nociceptin Receptor; Opioid Peptides; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2015 |
Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cisplatin; Disease Models, Animal; Female; Ganglia, Spinal; Humans; Hyperalgesia; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Sulfonamides; Ubiquitin Thiolesterase; Xenograft Model Antitumor Assays | 2015 |
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; Female; Flagellin; Ganglia, Spinal; Humans; Hyperalgesia; Lidocaine; Male; Mice; Mice, Knockout; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuralgia; Neurofilament Proteins; Neurons; Paclitaxel; Peripheral Nerve Injuries; Sensory System Agents; Toll-Like Receptor 5 | 2015 |
A Hyperresponsive HPA Axis May Confer Resilience Against Persistent Paclitaxel-Induced Mechanical Hypersensitivity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Hyperalgesia; Hypothalamo-Hypophyseal System; Male; Neuralgia; Paclitaxel; Pituitary-Adrenal System; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Stress, Physiological | 2016 |
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system.
Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease Models, Animal; Edema; Freund's Adjuvant; Hyperalgesia; Interleukin-1beta; Medicine, Chinese Traditional; Mice; Monoterpenes; Motor Activity; Paclitaxel; Pain Measurement; Theobromine; Theophylline; Xanthines | 2015 |
Paclitaxel-induced peripheral neuropathy increases substance P release in rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Gene Expression Regulation; Hyperalgesia; Male; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Spinal Cord; Substance P | 2016 |
Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.
Topics: Anesthetics; Animals; Antibodies; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Agents, Phytogenic; Bone Density Conservation Agents; Cell Movement; Chemokine CCL2; Clodronic Acid; Disease Models, Animal; Drug Administration Routes; Ganglia, Spinal; GAP-43 Protein; Hyperalgesia; Isoflurane; Lipopolysaccharides; Macrophages; Male; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Spinal Cord; Spleen; Time Factors; Tumor Necrosis Factor-alpha; Ubiquitin Thiolesterase | 2016 |
Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Female; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Neuralgia; Nociception; Paclitaxel; Rats; Rats, Wistar; Visceral Pain | 2016 |
Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Carnosine; Cell Line, Tumor; Cell Survival; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neoplasms; Organometallic Compounds; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Tumor Burden; Zinc Compounds | 2016 |
mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain.
Topics: Action Potentials; Animals; Antagomirs; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Inhibitory Postsynaptic Potentials; Male; MicroRNAs; Neuralgia; Paclitaxel; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Transcription Activator-Like Effector Nucleases | 2016 |
Oxidative stress in the development, maintenance and resolution of paclitaxel-induced painful neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Cells, Cultured; Disease Models, Animal; Disease Progression; Ganglia, Spinal; Hyperalgesia; Lumbar Vertebrae; Male; Microglia; Neurons; Oxidative Stress; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats, Sprague-Dawley; Reactive Oxygen Species; Spinal Cord | 2016 |
Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats.
Topics: Animals; Antibodies, Neutralizing; Antineoplastic Agents; Disease Models, Animal; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Male; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Recombinant Proteins; Sciatic Nerve; Thrombomodulin; Toll-Like Receptor 4; Vincristine | 2016 |
Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice.
Topics: Amides; Amines; Animals; Cyclohexanecarboxylic Acids; Drug Synergism; Ethanolamines; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Paclitaxel; Palmitic Acids; PPAR alpha | 2016 |
Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems.
Topics: Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Phytogenic; Desipramine; Hyperalgesia; Male; Neuralgia; Paclitaxel; Rats, Sprague-Dawley; Receptors, Cannabinoid; Signal Transduction | 2016 |
MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical hypersensitivity in a rat pain model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Disease Models, Animal; Hyperalgesia; In Vitro Techniques; Male; Mitochondria; Neuralgia; Organophosphorus Compounds; Oxidative Stress; Paclitaxel; Rats; Rats, Sprague-Dawley; Ubiquinone | 2016 |
Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azabicyclo Compounds; Benzamides; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Humans; Hyperalgesia; Male; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Spinal Cord; Sulfonamides; Toll-Like Receptor 4 | 2017 |
Effects of paclitaxel on mechanical sensitivity and morphine reward in male and female C57Bl6 mice.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Female; Hyperalgesia; Male; Mice; Morphine; Paclitaxel; Random Allocation; Reinforcement, Psychology; Reward; Self Administration | 2016 |
Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Chemokine CCL2; Chemokine CCL3; Ganglia, Spinal; Gene Expression; Hyperalgesia; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neuralgia; Neurofilament Proteins; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Receptors, Purinergic P2Y12; Sensory Receptor Cells; Spinal Cord; Spleen; T-Lymphocytes, Regulatory | 2017 |
Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model.
Topics: Adrenergic Neurons; Animals; Axons; Calcitonin Gene-Related Peptide; Disease Models, Animal; Electrophysiological Phenomena; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Macrophages; Motor Activity; Nerve Regeneration; Paclitaxel; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve; Silicone Elastomers; Spinal Cord Dorsal Horn; Stilbamidines | 2017 |
Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.
Topics: Animals; Drugs, Chinese Herbal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Neuroprotective Agents; NF-kappa B; Paclitaxel; Peripheral Nervous System Diseases; Phosphorylation; Signal Transduction; Spinal Cord | 2017 |
Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A
Topics: Administration, Topical; Animals; Antineoplastic Agents; Benzoates; Demyelinating Diseases; Glucosides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoterpenes; Neuralgia; Paclitaxel; Paeonia; Phytotherapy; Plant Extracts; Receptor, Adenosine A1 | 2017 |
Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse.
Topics: Anhedonia; Animals; Antineoplastic Agents, Phytogenic; Anxiety; Behavior, Animal; Carboplatin; Depression; Epidermis; Hyperalgesia; Male; Mice, Inbred C57BL; Motor Activity; Nociceptive Pain; Paclitaxel; Random Allocation | 2017 |
The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Hyperalgesia; Immunosuppressive Agents; Locomotion; Male; Minocycline; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Rotarod Performance Test; Statistics, Nonparametric; Thalidomide | 2008 |
Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Axons; Cell Line, Tumor; Cold Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neoplasm Transplantation; Neurites; Paclitaxel; Peripheral Nervous System Diseases; Polysaccharides; Rats; Rats, Sprague-Dawley | 2009 |
Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Carrageenan; Dantrolene; Disease Models, Animal; Edema; Hyperalgesia; Inflammation; Injections; Male; Motor Activity; Paclitaxel; Polyneuropathies; Rats; Rats, Sprague-Dawley | 2009 |
Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel.
Topics: Analysis of Variance; Animals; Area Under Curve; Cholestenones; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Evoked Potentials; Hyperalgesia; Male; Nerve Fibers; Neuralgia; Neuroprotective Agents; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Ubiquitin Thiolesterase | 2009 |
Prevention of paclitaxel-induced allodynia by minocycline: Effect on loss of peripheral nerve fibers and infiltration of macrophages in rats.
Topics: Activating Transcription Factor 3; Animals; Cell Movement; Fluorescent Antibody Technique; Ganglia, Spinal; Hyperalgesia; Macrophages; Male; Minocycline; Nerve Fibers; Paclitaxel; Peripheral Nerves; Protein Transport; Rats; Rats, Sprague-Dawley; Up-Regulation | 2010 |
Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Ganglia, Spinal; Hyperalgesia; Male; Neural Conduction; Paclitaxel; Pain; Peripheral Nervous System Diseases; Phosphoglycerate Dehydrogenase; Rats; Rats, Sprague-Dawley; Satellite Cells, Perineuronal; Serine; Stereoisomerism; Tail; Touch | 2011 |
Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline.
Topics: Animals; Disease Models, Animal; Epidermis; Hyperalgesia; Male; Minocycline; Nerve Fibers; Neurotoxins; Paclitaxel; Rats; Rats, Sprague-Dawley | 2011 |
Anti-nociceptive effect of kinin B₁ and B₂ receptor antagonists on peripheral neuropathy induced by paclitaxel in mice.
Topics: Analgesics; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Hyperalgesia; Kinins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Paclitaxel; Peripheral Nervous System Diseases; Receptor, Bradykinin B1; Receptor, Bradykinin B2; RNA, Messenger | 2011 |
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Blotting, Western; Calcium Channels, T-Type; Cyclopropanes; Enzyme Inhibitors; HEK293 Cells; Humans; Hydrogen Sulfide; Hyperalgesia; Male; Naphthalenes; Neuralgia; Paclitaxel; Patch-Clamp Techniques; Rats; Rats, Wistar | 2011 |
Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice.
Topics: Analgesics; Animals; Behavior, Animal; Cannabidiol; Cold Temperature; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Sex Factors; Time Factors | 2011 |
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Topics: Analysis of Variance; Anilides; Animals; Ankyrins; Antineoplastic Agents, Phytogenic; Capsaicin; Carbazoles; Central Nervous System; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Oligopeptides; Paclitaxel; Pain Measurement; Physical Stimulation; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, PAR-2; Sulfonamides; Time Factors; TRPV Cation Channels; Tryptases; Type C Phospholipases | 2011 |
The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electroacupuncture; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Random Allocation; Rats; Rats, Sprague-Dawley; Somatostatin | 2011 |
Comparison of peripheral neuropathy induced by standard and nanoparticle albumin-bound paclitaxel in rats.
Topics: Albumins; Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Dose-Response Relationship, Drug; Hand Strength; Hyperalgesia; Male; Motor Skills; Nanoparticles; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley | 2011 |
Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Diabetes Mellitus, Experimental; Disease Models, Animal; Ganglia, Spinal; Glucose Tolerance Test; Glutathione Peroxidase; Hydrogen Peroxide; Hyperalgesia; Hypoxanthine Phosphoribosyltransferase; Male; Microscopy, Electron, Transmission; Mitochondria; Paclitaxel; Pain Measurement; Pain Threshold; Phospholipid Hydroperoxide Glutathione Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sciatic Nerve; Sensory Receptor Cells; Streptozocin; Time Factors; TRPA1 Cation Channel; TRPC Cation Channels | 2012 |
Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel.
Topics: Animals; Antineoplastic Agents; Axons; Hyperalgesia; Male; Neural Conduction; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley; Sural Nerve; Tibial Nerve | 2012 |
Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin.
Topics: Animals; Antineoplastic Agents; Antirheumatic Agents; Auranofin; Behavior, Animal; Drug Interactions; Hyperalgesia; Male; Mitochondria; Nerve Fibers; Neuralgia; Oligomycins; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Rotenone; Time Factors; Uncoupling Agents | 2012 |
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism.
Topics: Acetanilides; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Drug Hypersensitivity; Glutathione; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Paclitaxel; Peripheral Nervous System Diseases; Purines; Pyrroles; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2012 |
Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation Mediators; Male; Morpholines; Naphthalenes; Neuroglia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord | 2012 |
Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system.
Topics: Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Benzofurans; Blotting, Western; CD11b Antigen; Cricetinae; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Profiling; Glial Fibrillary Acidic Protein; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Immunohistochemistry; Lipopolysaccharides; Male; Mice; Mice, Knockout; Microscopy, Confocal; Neuroglia; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB2; Spinal Cord; Toll-Like Receptor 2 | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Interactions; Duloxetine Hydrochloride; Etodolac; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mexiletine; Mice; Paclitaxel; Peripheral Nervous System Diseases; Pregabalin; Thiophenes; Tissue Distribution | 2012 |
Analgesic effect of magnetic stimulation on paclitaxel-induced peripheral neuropathic pain in mice.
Topics: Analgesia; Analgesics; Animals; Hyperalgesia; Magnetic Field Therapy; Male; Mice; Mice, Inbred ICR; Neuralgia; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases | 2012 |
Paclitaxel-induced neuropathic pain is age dependent and devolves on glial response.
Topics: Age Factors; Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Calcium-Binding Proteins; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Mice; Mice, Inbred Strains; Microfilament Proteins; Microglia; Neuralgia; Nociceptors; Paclitaxel; Physical Stimulation; Spinal Cord | 2013 |
Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice.
Topics: Acute Pain; Acyclic Monoterpenes; Animals; Antineoplastic Agents, Phytogenic; Drosophila Proteins; Hyperalgesia; Injections; Male; Mice; Monoterpenes; Naloxone; Narcotic Antagonists; Paclitaxel; Protein Serine-Threonine Kinases | 2012 |
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice.
Topics: Animals; Behavior, Animal; Calcium Channels; Capsaicin; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Ganglia, Spinal; Hyperalgesia; Isothiocyanates; Male; Menthol; Mice; Mice, Inbred C57BL; Nociception; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2012 |
Matrix metalloproteinase inhibitor COL-3 prevents the development of paclitaxel-induced hyperalgesia in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; CD11b Antigen; Chemokines; Cytokines; Dose-Response Relationship, Drug; Female; Gene Expression; Hyperalgesia; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Paclitaxel; Polymerase Chain Reaction; Spinal Cord; Spleen; Tetracyclines | 2013 |
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy.
Topics: Animals; Benzylamines; Chromones; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperalgesia; Indoles; Male; Paclitaxel; Peripheral Nervous System Diseases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, CXCR4; Signal Transduction; Time Factors; Treatment Outcome | 2012 |
Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats.
Topics: Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Calcitonin; Cold Temperature; Hyperalgesia; Isothiocyanates; Male; Menthol; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley | 2012 |
Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Blotting, Western; Brain; Cold Temperature; Female; Hyperalgesia; MAP Kinase Signaling System; Membranes; Mice; Mice, Knockout; Morpholines; Narcotics; Neuralgia; Paclitaxel; Pain Measurement; Pentazocine; Physical Stimulation; Piperazines; Postural Balance; Pyrazoles; Receptors, sigma; Sigma-1 Receptor | 2012 |
Paclitaxel increases high voltage-dependent calcium channel current in dorsal root ganglion neurons of the rat.
Topics: Action Potentials; Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Size; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Male; Nerve Tissue Proteins; Neuralgia; Neurons; Neurotoxicity Syndromes; Paclitaxel; Rats; Rats, Wistar; Up-Regulation | 2012 |
[Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced peripheral neuropathy].
Topics: Animals; Antineoplastic Agents, Phytogenic; Ganglia, Spinal; Humans; Hyperalgesia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Satellite Cells, Perineuronal; Serine | 2013 |
[Neurotoxicity of weekly TP (weekly paclitaxel + consecutive low-dose CDDP) therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Arthralgia; Carboplatin; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hyperalgesia; Muscle, Skeletal; Muscular Diseases; Ovarian Neoplasms; Paclitaxel; Pain Measurement; Surveys and Questionnaires | 2004 |
Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Disease Models, Animal; Female; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred Strains; Paclitaxel; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Species Specificity | 2004 |
Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Calcium; Cation Transport Proteins; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Hypotonic Solutions; Integrins; Ion Channels; Male; Neuralgia; Nociceptors; Oligonucleotides, Antisense; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; TRPV Cation Channels | 2004 |
Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.
Topics: Amino Acid Transport System X-AG; Animals; Antineoplastic Agents, Phytogenic; Cell Communication; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hyperalgesia; Male; Neuroglia; Nociceptors; Paclitaxel; Peripheral Nervous System Diseases; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Symporters; Synaptic Transmission | 2005 |
A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Benzoxazines; Cannabinoids; Disease Models, Animal; Hot Temperature; Humans; Hyperalgesia; Male; Morpholines; Naphthalenes; Neuralgia; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Wistar; Sensory Thresholds; Touch; Treatment Outcome | 2005 |
Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia.
Topics: Amino Acid Transport System X-AG; Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Data Interpretation, Statistical; Down-Regulation; Electric Stimulation; Electrophysiology; Evoked Potentials; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Neurons; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2006 |
Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells.
Topics: Activating Transcription Factor 3; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Agents, Phytogenic; CD11b Antigen; Chemotaxis, Leukocyte; Disease Models, Animal; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Hyperalgesia; Injections, Intravenous; Macrophages; Male; Microglia; Neurons, Afferent; Paclitaxel; Peripheral Nerves; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Satellite Cells, Perineuronal; Schwann Cells | 2007 |
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; CD11b Antigen; Cytokines; Disease Models, Animal; Ganglia, Spinal; Genetic Therapy; Hyperalgesia; Injections, Spinal; Interleukin-10; Interleukin-1beta; Male; Meninges; Neuroglia; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Plasmids; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; RNA, Messenger; Spinal Cord; Tumor Necrosis Factor-alpha | 2007 |
Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice.
Topics: Anesthetics, Local; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Pain Measurement; Tetrodotoxin | 2008 |
Alcohol-induced stress in painful alcoholic neuropathy.
Topics: Adrenalectomy; Alcoholic Neuropathy; Alcohols; Analysis of Variance; Animals; Drug Interactions; Epinephrine; Hormone Antagonists; Hyperalgesia; Male; Mifepristone; Neuralgia; Oligonucleotides, Antisense; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Receptors, Glucocorticoid; Stress, Physiological; Time Factors; Zalcitabine | 2008 |
Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Behavior, Animal; Drug Combinations; Drugs, Chinese Herbal; Glycyrrhiza; Hyperalgesia; Male; Mice; Paclitaxel; Paeonia; Pain; Pain Measurement; Peripheral Nervous System Diseases; Phenylpropionates; Physical Stimulation | 2009 |
Description of a short-term Taxol-induced nociceptive neuropathy in rats.
Topics: Animals; Hair; Hand Strength; Hot Temperature; Hyperalgesia; Male; Motor Activity; Neural Conduction; Neuralgia; Nociceptors; Paclitaxel; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Somatosensory Disorders | 2000 |
A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Cold Temperature; Disease Models, Animal; Hindlimb; Hot Temperature; Hyperalgesia; Male; Motor Activity; Paclitaxel; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Tail | 2001 |
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cyclic AMP-Dependent Protein Kinases; Hot Temperature; Hyperalgesia; Isoenzymes; Male; Nerve Fibers; Nociceptors; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley | 2001 |