clobazam has been researched along with Allodynia in 4 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Excerpt | Relevance | Reference |
---|---|---|
"Clobazam was chosen because of its relatively low sedative properties and CLN because of its use in neuropathic pain." | 2.80 | GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers. ( Besson, M; Curatolo, M; Daali, Y; Desmeules, J; Matthey, A; Poncet, A; Vuillemier, P; Zeilhofer, HU, 2015) |
"The area of static hyperalgesia after intradermal capsaicin injection was the primary endpoint." | 2.78 | Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study. ( Arendt-Nielsen, L; Besson, M; Curatolo, M; Desmeules, J; Vuilleumier, PH, 2013) |
"Clobazam is a 1,5-BZD, which exhibits less cognitive side effects than other benzodiazepines." | 1.39 | Antihyperalgesic effect of the GABA(A) ligand clobazam in a neuropathic pain model in mice: a pharmacokinetic-pharmacodynamic study. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Di Lio, A; Zeilhofer, HU, 2013) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 4 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Vuilleumier, PH | 1 |
Besson, M | 4 |
Desmeules, J | 4 |
Arendt-Nielsen, L | 1 |
Curatolo, M | 2 |
Matthey, A | 2 |
Daali, Y | 3 |
Poncet, A | 1 |
Vuillemier, P | 1 |
Zeilhofer, HU | 3 |
Ralvenius, WT | 1 |
Acuña, MA | 1 |
Benke, D | 1 |
Rudolph, U | 1 |
Di Lio, A | 1 |
Dayer, P | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effects of Gaba-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers[NCT01011036] | Phase 3 | 17 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 trials available for clobazam and Allodynia
Article | Year |
---|---|
Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study.
Topics: Adolescent; Adult; Analgesics; Benzodiazepines; Clobazam; Clonazepam; Cross-Sectional Studies; Doubl | 2013 |
GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers.
Topics: Adolescent; Adult; Benzodiazepines; Clobazam; Clonazepam; Cross-Over Studies; Cytochrome P-450 CYP2C | 2015 |
2 other studies available for clobazam and Allodynia
Article | Year |
---|---|
The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.
Topics: Analgesics, Non-Narcotic; Animals; Benzodiazepines; Clobazam; Dose-Response Relationship, Drug; Fema | 2016 |
Antihyperalgesic effect of the GABA(A) ligand clobazam in a neuropathic pain model in mice: a pharmacokinetic-pharmacodynamic study.
Topics: Animals; Benzodiazepines; Brain; Clobazam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |