Page last updated: 2024-10-25

clobazam and Allodynia

clobazam has been researched along with Allodynia in 4 studies

Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.

Research Excerpts

ExcerptRelevanceReference
"Clobazam was chosen because of its relatively low sedative properties and CLN because of its use in neuropathic pain."2.80GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers. ( Besson, M; Curatolo, M; Daali, Y; Desmeules, J; Matthey, A; Poncet, A; Vuillemier, P; Zeilhofer, HU, 2015)
"The area of static hyperalgesia after intradermal capsaicin injection was the primary endpoint."2.78Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study. ( Arendt-Nielsen, L; Besson, M; Curatolo, M; Desmeules, J; Vuilleumier, PH, 2013)
"Clobazam is a 1,5-BZD, which exhibits less cognitive side effects than other benzodiazepines."1.39Antihyperalgesic effect of the GABA(A) ligand clobazam in a neuropathic pain model in mice: a pharmacokinetic-pharmacodynamic study. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Di Lio, A; Zeilhofer, HU, 2013)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vuilleumier, PH1
Besson, M4
Desmeules, J4
Arendt-Nielsen, L1
Curatolo, M2
Matthey, A2
Daali, Y3
Poncet, A1
Vuillemier, P1
Zeilhofer, HU3
Ralvenius, WT1
Acuña, MA1
Benke, D1
Rudolph, U1
Di Lio, A1
Dayer, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Gaba-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers[NCT01011036]Phase 317 participants (Actual)Interventional2009-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for clobazam and Allodynia

ArticleYear
Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Analgesics; Benzodiazepines; Clobazam; Clonazepam; Cross-Sectional Studies; Doubl

2013
GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers.
    Pain, 2015, Volume: 156, Issue:3

    Topics: Adolescent; Adult; Benzodiazepines; Clobazam; Clonazepam; Cross-Over Studies; Cytochrome P-450 CYP2C

2015

Other Studies

2 other studies available for clobazam and Allodynia

ArticleYear
The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.
    Neuropharmacology, 2016, Volume: 109

    Topics: Analgesics, Non-Narcotic; Animals; Benzodiazepines; Clobazam; Dose-Response Relationship, Drug; Fema

2016
Antihyperalgesic effect of the GABA(A) ligand clobazam in a neuropathic pain model in mice: a pharmacokinetic-pharmacodynamic study.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:3

    Topics: Animals; Benzodiazepines; Brain; Clobazam; Disease Models, Animal; Dose-Response Relationship, Drug;

2013