enkephalin, leucine and Allodynia

enkephalin, leucine has been researched along with Allodynia in 62 studies

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-19907 (11.29)18.7374
1990's16 (25.81)18.2507
2000's15 (24.19)29.6817
2010's18 (29.03)24.3611
2020's6 (9.68)2.80

Authors

AuthorsStudies
Dallel, R; Descheemaeker, A; Luccarini, P; Ouimet, T; Poras, H; Wurm, M1
Berg, KA; Chavera, TS; Clarke, WP; Jamshidi, RJ; Jennings, EM; LoCoco, PM; Smith, HR; Sullivan, LC1
Grace, PM; Heijnen, CJ; Junigan, JM; Kavelaars, A; Trinh, R; Zhang, J1
Chen, D; Fang, Q; Hu, X; Li, N; Shi, Y; Xu, B; Zhang, M; Zhang, N; Zhang, Q; Zhang, R1
Antoniazzi, MM; Giardini, AC; Jared, SGS; Kimura, LF; Mattaraia, VGM; Pagano, RL; Picolo, G; Sant'Anna, MB; Zambelli, VO1
Al-Madol, M; Khalefa, BI; Li, L; Mousa, SA; Schäfer, M; Shaqura, M; Treskatsch, S1
Bennett, AJ; Devonshire, IM; Hathway, GJ; Kwok, CHT1
Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JL; Kohli, SK1
Chou, AH; Day, YJ; Lee, CM; Lee, HC; Liao, CC; Lin, YC; Liou, JT; Mao, CC1
Chen, P; Hong, Y; Li, J; Wang, D1
Bellinger, LL; Kramer, PR; Umorin, M1
Han, BX; Rodriguez, E; Takatoh, J; Wang, F; Zhang, Y; Zhao, S; Zhou, X1
Benedet, T; Dopazo, JM; Ghimire, K; Gonzalez, P; Mellstrom, B; Naranjo, JR; Oliveros, JC; Palczewska, M1
García Gutiérrez, MS; Maldonado, R; Manzanares, J; Negrete, R1
Cai, Z; Cheng, X; Guo, Q; Hu, C; Lu, Y; Wu, Z; Zhang, Q1
Baddack-Werncke, U; Busch-Dienstfertig, M; González-Rodríguez, S; Grobe, J; Lipp, M; Maddila, SC; Müller, G; Stein, C1
Li, H; Sun, Q; Sun, Y; Tian, Y; Zhang, D1
Hervera, A; Leánez, S; Pol, O1
Hino, M; Horiuchi, H; Morino, T; Ogata, T; Yamamoto, H1
Baamonde, A; Fournié-Zaluski, MC; González-Rodríguez, S; Hidalgo, A; Menéndez, L; Pevida, M; Roques, BP1
Buscher, D; Díaz, A; Hurlé, JM; Hurlé, MA; Izpisúa-Belmonte, JC; Lantero, A; Merino, D; Merino, R; Morchón, N; Tramullas, M; Villar, A1
Chen, JY; Cheng, YC; Chien, CC; Lin, JY; Lin, SC; Ling, QD; Tsou, TS; Wen, YR1
Chen, S; Hao, W; Huang, Y; Luo, A; Yang, N; Zhao, J; Zuo, P1
Guo, Q; Huang, C; Pan, Y; Yan, J; Yang, Y; Zou, W1
Campillo, A; González-Cuello, A; Laorden, ML; Puig, MM; Romero, A; Romero-Alejo, E; Vasconcelos, N1
Clark, JD; Li, X; Liang, D; Lighthall, G1
Jones, T; Laurito, CE; Lu, Y; Wilson, SP; Yeomans, DC1
Caron, MG; Chavkin, C; Czyzyk, TA; Lefkowitz, RJ; McLaughlin, JP; Petraschka, M; Pintar, JE; Terman, GW; Westenbroek, RE; Xu, M1
Cho, HJ; Hwang, SH; Kang, BS; Kim, DS; Lee, HL; Lee, KM; Park, JS; Son, SJ1
Arend, A; Aunapuu, M; Bourin, M; Kõks, S; Kurrikoff, K; Matsui, T; Vasar, E1
Laurito, CE; Lu, Y; Pappas, GD; Peters, MC; Vota-Vellis, G; Wilson, SP; Yeomans, DC1
Chavkin, C; Gendron, L; Pintar, JE1
Alguacil, LF; Dilorenzo, L; Ezquerra, L; Franklin, B; Herradon, G; Nguyen, T; Rossenfeld, J; Silos-Santiago, I; Siso, A; Wang, C1
Ferreira, SH1
Green, PG; Heller, PH; Khasar, SG; Levine, JD; Taiwo, YO; Wang, JF1
Green, PG; Ho, T; Khasar, SG; Levine, JD1
Hammond, DL; Stewart, PE1
Aley, KO; Green, PG; Levine, JD1
Aley, KO; Levine, JD; Reichling, DB1
Aley, KO; Levine, JD3
Kamei, J; Kawai, K; Mizoguchi, H; Mizusuna, A; Nagase, H; Narita, M; Suzuki, T; Tseng, LF1
Caudle, RM; Dubner, R; Ho, J; Mannes, AJ1
Imbe, H; Ren, K1
Franklin, E; MacArthur, L; Pfaffenroth, E; Ren, K; Ruda, MA1
Maldonado, R; Valjent, E; Valverde, O; Zimmer, A; Zimmer, AM1
Beaufour, C; Braz, J; Cesselin, F; Coutaux, A; Epstein, AL; Hamon, M; Pohl, M1
Befort, K; Brenner, GJ; Ji, RR; Woolf, CJ1
Cheng, HY; Crackower, M; Goncalves, J; Ikura, M; Joza, NA; Kockeritz, LK; Laviolette, SR; Oliveira-dos-Santos, AJ; Penninger, JM; Pitcher, GM; Salter, MW; Sarosi, I; Tong, KI; van der Kooy, D; Wada, T; Whishaw, IQ; Woodgett, JR1
Ferreira, SH; Nakamura, M2
Burgis, V; Edwards, JD; Frederickson, RC1
Heller, PH; Levine, JD; Taiwo, YO1
Dubner, R; Hylden, JL; Ren, K; Ruda, MA; Williams, GM1
Hylden, JL; Noguchi, K; Ruda, MA1
Dubner, R; Hylden, JL; Iadarola, MJ; Nahin, RL; Thomas, DA1
Draisci, G; Iadarola, MJ1
Civelli, O; Douglass, J; Iadarola, MJ; Naranjo, JR1
Garrett, NL; Godfrey, L; Iannitelli, A; Imbert, I; King, T; Lalatsa, A; Moger, J; Porreca, F; Schätzlein, AG; Soundararajan, R; Uchegbu, IF1
Cailleau, C; Coudore, F; Couvreur, P; Feng, J; Gautier, A; Hamon, M; Lepetre-Mouelhi, S; Mura, S1
Browne, JL; Pilcher, CW1

Other Studies

62 other study(ies) available for enkephalin, leucine and Allodynia

ArticleYear
Dual enkephalinase inhibitor PL37 as a potential novel treatment of migraine: evidence from a rat model.
    Brain : a journal of neurology, 2022, 08-27, Volume: 145, Issue:8

    Topics: Animals; Enkephalins; Hyperalgesia; Isosorbide Dinitrate; Male; Migraine Disorders; Neprilysin; Rats

2022
Age-related changes in peripheral nociceptor function.
    Neuropharmacology, 2022, 09-15, Volume: 216

    Topics: Aged; Analgesics, Opioid; Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Hyperalgesia; Nociceptors; Pain; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensory Receptor Cells

2022
HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022, 10-19, Volume: 42, Issue:42

    Topics: Analgesics, Opioid; Animals; Antibodies, Neutralizing; Antineoplastic Agents; Cisplatin; Enkephalin, Methionine; Enkephalins; Female; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Hyperalgesia; Ligands; Male; Mice; Mice, Inbred C57BL; Narcotic Antagonists; Neuralgia; Niacinamide; Receptors, Opioid, delta

2022
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    The journal of pain, 2023, Volume: 24, Issue:5

    Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Hyperalgesia; Mice; NAV1.7 Voltage-Gated Sodium Channel; Pain; Rats

2023
Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury.
    Experimental neurology, 2020, Volume: 332

    Topics: Animals; Cell Survival; Constriction, Pathologic; Endorphins; Enkephalins; Environment; Hyperalgesia; Male; Nerve Fibers; Neuralgia; Peripheral Nerve Injuries; Rats; Rats, Wistar; Receptors, Glucocorticoid; Sciatic Nerve; Spinal Cord; Weight-Bearing

2020
Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief.
    Molecular neurobiology, 2021, Volume: 58, Issue:11

    Topics: Acenaphthenes; Amphibian Proteins; Animals; Arthritis, Experimental; Corticotropin-Releasing Hormone; Enkephalins; Hyperalgesia; Interneurons; Male; Naloxone; Nociception; Pain; Peptide Hormones; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Spinal Cord; Urocortins

2021
Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat.
    Pain, 2014, Volume: 155, Issue:1

    Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation, Developmental; Hyperalgesia; Pain Threshold; Periaqueductal Gray; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord

2014
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
    Brain research, 2014, Jan-16, Volume: 1543

    Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Polymers; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Time Factors

2014
Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice.
    Pain, 2014, Volume: 155, Issue:7

    Topics: Animals; Behavior, Animal; beta-Endorphin; Central Nervous System Sensitization; Cytokines; Disease Models, Animal; Dynorphins; Enkephalins; Hyperalgesia; Inflammation; Interleukin-10; Interleukin-13; Interleukin-17; Interleukin-1beta; Interleukin-2; Interleukin-6; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neutrophils; Nociception; Peripheral Nerve Injuries; Peroxidase; Sciatic Nerve; T-Lymphocytes; Tumor Necrosis Factor-alpha

2014
Upregulation of pronociceptive mediators and downregulation of opioid peptide by adrenomedullin following chronic exposure to morphine in rats.
    Neuroscience, 2014, Nov-07, Volume: 280

    Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Drug Tolerance; Enkephalins; Ganglia, Spinal; Hyperalgesia; Male; Morphine; Narcotics; Neurons; Neurotransmitter Agents; Nitric Oxide Synthase Type I; Peptide Fragments; Rats, Sprague-Dawley; Receptors, Adrenomedullin; RNA, Messenger; Spinal Cord; Tissue Culture Techniques

2014
Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral mediated enkephalin overproduction in male and female rats.
    BMC neurology, 2015, Mar-15, Volume: 15

    Topics: Animals; Disease Models, Animal; Enkephalins; Female; Herpesviridae; Herpesviridae Infections; Hyperalgesia; Male; Masseter Muscle; Naloxone; Narcotic Antagonists; Nociception; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Nuclei

2015
Identifying local and descending inputs for primary sensory neurons.
    The Journal of clinical investigation, 2015, Oct-01, Volume: 125, Issue:10

    Topics: Afferent Pathways; Animals; Defective Viruses; Efferent Pathways; Enkephalins; Forelimb; GABAergic Neurons; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Interneurons; Nerve Net; Nerve Tissue Proteins; Neural Conduction; Neurons, Afferent; Neurons, Efferent; Nociception; Nociceptors; Posterior Horn Cells; Presynaptic Terminals; Rabies virus; Sensory Receptor Cells; Skin; Spinal Cord Dorsal Horn; Virus Replication

2015
Transcriptional repressor DREAM regulates trigeminal noxious perception.
    Journal of neurochemistry, 2017, Volume: 141, Issue:4

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cathepsin L; Enkephalins; Facial Pain; Hyperalgesia; Kv Channel-Interacting Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Monoacylglycerol Lipases; Nociception; Physical Stimulation; Protein Precursors; Repressor Proteins; Transcriptome; Trigeminal Nerve

2017
Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice.
    Neuropharmacology, 2017, Volume: 116

    Topics: Acetylation; Amygdala; Animals; Arthralgia; Chronic Pain; Cognition; Corticotropin-Releasing Hormone; Disease Models, Animal; Emotions; Enkephalins; Epigenesis, Genetic; Hippocampus; Histones; Hyperalgesia; Mice, Inbred C57BL; Mice, Knockout; Microglia; Osteoarthritis; Protein Precursors; Receptors, Opioid, kappa; Spinal Cord

2017
Nonviral vector plasmid DNA encoding human proenkephalin gene attenuates inflammatory and neuropathic pain-related behaviors in mice.
    Neuroscience letters, 2016, Nov-10, Volume: 634

    Topics: Adjuvants, Immunologic; Animals; Behavior, Animal; DNA; Enkephalins; Freund's Adjuvant; Genetic Therapy; Genetic Vectors; Humans; Hyperalgesia; Inflammation; Injections, Intramuscular; Injections, Spinal; Neuralgia; Pain; Pain Management; Plasmids; Protein Precursors; Sciatic Nerve

2016
Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis.
    Journal of neuroinflammation, 2017, 02-06, Volume: 14, Issue:1

    Topics: Analgesics, Opioid; Animals; Antibodies; Arthritis, Experimental; CD8 Antigens; CD8-Positive T-Lymphocytes; Collagen; Disease Models, Animal; Enkephalins; Female; Freund's Adjuvant; Functional Laterality; Hyperalgesia; Inflammation; Methionine; Mice; Mice, Inbred BALB C; Pain Measurement; Pain Threshold; Time Factors

2017
Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain.
    Pain research & management, 2017, Volume: 2017

    Topics: Analgesics; Animals; Bone Marrow Cells; Bone Neoplasms; Cancer Pain; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Enkephalins; Female; Genetic Therapy; Genetic Vectors; Humans; Hyperalgesia; Injections, Spinal; Naloxone; Pain Threshold; Protein Precursors; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation

2017
Peripheral antinociceptive effects of mu- and delta-opioid receptor agonists in NOS2 and NOS1 knockout mice during chronic inflammatory pain.
    European journal of pharmacology, 2009, Jan-05, Volume: 602, Issue:1

    Topics: Analgesics; Animals; Chronic Disease; Edema; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Neurotransmitter Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors

2009
Intrathecal transplantation of autologous macrophages genetically modified to secrete proenkephalin ameliorated hyperalgesia and allodynia following peripheral nerve injury in rats.
    Neuroscience research, 2009, Volume: 64, Issue:1

    Topics: Animals; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Macrophages; Male; Pain; Pain Management; Pain Measurement; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Neuropathy; Spinal Cord; Time Factors; Transfection; Transplantation, Autologous

2009
Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors.
    Neuroscience letters, 2009, Nov-20, Volume: 465, Issue:3

    Topics: Animals; Cell Line, Tumor; Enkephalins; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C3H; Osteosarcoma; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X3

2009
BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-27, Volume: 30, Issue:4

    Topics: Activins; Afferent Pathways; Animals; Bone Morphogenetic Protein 7; Cells, Cultured; Disease Models, Animal; Enkephalins; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Knockout; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nerves; Peripheral Nervous System Diseases; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, delta; Sciatic Neuropathy; Signal Transduction; Spinal Cord; Transforming Growth Factor beta; Up-Regulation

2010
Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult.
    BMC neuroscience, 2010, Oct-25, Volume: 11

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Enkephalins; Gene Expression Regulation; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Physical Stimulation; Protein Precursors; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation

2010
Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.
    Science China. Life sciences, 2010, Volume: 53, Issue:12

    Topics: Amines; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Enkephalins; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Pain Measurement

2010
Microinjection of HSV-1 amplicon vector-mediated human proenkephalin into the periaqueductal grey attenuates neuropathic pain in rats.
    The International journal of neuroscience, 2012, Volume: 122, Issue:4

    Topics: Animals; Constriction, Pathologic; Enkephalin, Leucine; Enkephalins; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Hyperalgesia; Male; Microinjections; Naloxone; Narcotic Antagonists; Neuralgia; Pain Measurement; Pain Threshold; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recombination, Genetic

2012
Effects of surgery and/or remifentanil administration on the expression of pERK1/2, c-Fos and dynorphin in the dorsal root ganglia in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:4

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dynorphins; Enkephalins; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pain, Postoperative; Piperidines; Protein Precursors; Proto-Oncogene Proteins c-fos; Remifentanil; RNA, Messenger

2012
Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine.
    Neuroscience, 2003, Volume: 121, Issue:4

    Topics: Animals; Drug Administration Schedule; Drug Tolerance; Enkephalins; Gene Expression; Heme Oxygenase (Decyclizing); Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Protein Precursors; Reaction Time; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord

2003
Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 9, Issue:1

    Topics: Administration, Cutaneous; Animals; Enkephalins; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herpesviridae; Hyperalgesia; Immunohistochemistry; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Pertussis Toxin; Protein Precursors; Receptors, Opioid, mu; Receptors, sigma; Somatostatin

2004
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, May-12, Volume: 24, Issue:19

    Topics: Animals; Astrocytes; Disease Models, Animal; Disease Progression; Drug Tolerance; Dynorphins; Enkephalins; G-Protein-Coupled Receptor Kinase 3; Hyperalgesia; Lumbosacral Region; Mice; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Narcotics; Neuralgia; Neurons; Protein Precursors; Protein Serine-Threonine Kinases; Receptors, Opioid; Receptors, Opioid, kappa; Sciatic Neuropathy; Spinal Cord

2004
Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity.
    The European journal of neuroscience, 2004, Volume: 19, Issue:12

    Topics: Animals; Cyclooxygenase 2; Enkephalins; Enzyme Inhibitors; Freund's Adjuvant; Gene Expression; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Isoenzymes; Male; NF-kappa B; Pain; Prostaglandin-Endoperoxide Synthases; Protein Precursors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; Spinal Cord; Up-Regulation

2004
Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice.
    The European journal of neuroscience, 2004, Volume: 20, Issue:6

    Topics: Animals; Benzodiazepinones; Disease Models, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Gene Expression; Hyperalgesia; Inflammation; Ligation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phenylurea Compounds; Pro-Opiomelanocortin; Protein Precursors; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Neuropathy; Time Factors

2004
Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2006, Volume: 13, Issue:3

    Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Enkephalins; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Hyperalgesia; Macaca; Morphine; Nociceptors; Reaction Time; Simplexvirus; Skin

2006
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.
    Neuroscience, 2007, Dec-19, Volume: 150, Issue:4

    Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin

2007
Noradrenergic and opioidergic alterations in neuropathy in different rat strains.
    Neuroscience letters, 2008, Jun-20, Volume: 438, Issue:2

    Topics: Animals; Chronic Disease; Denervation; Disease Models, Animal; Down-Regulation; Dynorphins; Enkephalins; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Ligation; Male; Neurons, Afferent; Norepinephrine; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Protein Precursors; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Opioid, delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity; Spinal Cord; Tyrosine 3-Monooxygenase

2008
Local analgesic effect of morphine on the hyperalgesia induced by cAMP, Ca2+, isoprenaline, and PGE2.
    Advances in prostaglandin and thromboxane research, 1980, Volume: 8

    Topics: Acetylcholine; Animals; Calcium; Carbachol; Cyclic AMP; Cyclic GMP; Enkephalins; Humans; Hyperalgesia; Hyperesthesia; Isoproterenol; Morphine; Nociceptors; Prostaglandin Antagonists; Prostaglandins E; Synaptic Transmission

1980
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
    Neuroscience, 1995, Volume: 67, Issue:1

    Topics: Adenosine; Adenylate Cyclase Toxin; Amino Acid Sequence; Analgesics; Animals; Antihypertensive Agents; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Hyperalgesia; Male; Molecular Sequence Data; Pertussis Toxin; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Virulence Factors, Bordetella

1995
Comparison of prostaglandin E1- and prostaglandin E2-induced hyperalgesia in the rat.
    Neuroscience, 1994, Volume: 62, Issue:2

    Topics: Alprostadil; Analgesics; Animals; Diabetes Mellitus, Experimental; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hindlimb; Hydrazines; Hyperalgesia; Male; Oxazepines; Pain; Rats; Rats, Sprague-Dawley

1994
Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord

1994
Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:12

    Topics: Adenosine; Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Rats; Rats, Sprague-Dawley; Xanthines

1995
Vincristine hyperalgesia in the rat: a model of painful vincristine neuropathy in humans.
    Neuroscience, 1996, Volume: 73, Issue:1

    Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hot Temperature; Hyperalgesia; Injections, Intravenous; Male; Neurons, Afferent; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Vincristine

1996
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jan-15, Volume: 17, Issue:2

    Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine

1997
Delta-1 opioid receptor-mediated antinociceptive properties of a nonpeptidic delta opioid receptor agonist, (-)TAN-67, in the mouse spinal cord.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pyrrolidines; Quinolines; Reaction Time; Receptors, Opioid, delta; Spinal Cord

1997
Putative kappa-2 opioid agonists are antihyperalgesic in a rat model of inflammation.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1

    Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

1997
Dissociation of tolerance and dependence for opioid peripheral antinociception in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, May-15, Volume: 17, Issue:10

    Topics: Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Oxytocics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Second Messenger Systems; Substance-Related Disorders

1997
Different mechanisms mediate development and expression of tolerance and dependence for peripheral mu-opioid antinociception in rat.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Oct-15, Volume: 17, Issue:20

    Topics: Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Second Messenger Systems; Substance-Related Disorders

1997
Orofacial deep and cutaneous tissue inflammation differentially upregulates preprodynorphin mRNA in the trigeminal and paratrigeminal nuclei of the rat.
    Brain research. Molecular brain research, 1999, Apr-06, Volume: 67, Issue:1

    Topics: Animals; Dynorphins; Enkephalins; Freund's Adjuvant; Gene Expression; Hyperalgesia; In Situ Hybridization; Male; Neurogenic Inflammation; Neurons, Afferent; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Skin; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Nuclei

1999
Descending modulation of opioid-containing nociceptive neurons in rats with peripheral inflammation and hyperalgesia.
    Neuroscience, 1999, Volume: 88, Issue:2

    Topics: Animals; Blotting, Northern; Calcitonin Gene-Related Peptide; Colchicine; Denervation; Dynorphins; Enkephalins; Freund's Adjuvant; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Male; Neurons, Afferent; Nociceptors; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Tachykinins

1999
Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Dec-15, Volume: 20, Issue:24

    Topics: Acute Disease; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Body Temperature; Body Weight; Brain; Chronic Disease; Dronabinol; Drug Tolerance; Enkephalins; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Protein Precursors; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome

2000
Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-15, Volume: 21, Issue:20

    Topics: Animals; Arthritis; Arthritis, Experimental; Disease Models, Animal; Disease Progression; Enkephalins; Freund's Adjuvant; Ganglia, Spinal; Genes, Reporter; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Hindlimb; Hyperalgesia; Male; Neurons, Afferent; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Terminal Repeat Sequences; Treatment Outcome

2001
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jan-15, Volume: 22, Issue:2

    Topics: Animals; Butadienes; Disease Models, Animal; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Pain; Posterior Horn Cells; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Up-Regulation

2002
DREAM is a critical transcriptional repressor for pain modulation.
    Cell, 2002, Jan-11, Volume: 108, Issue:1

    Topics: Animals; Base Sequence; Behavior, Animal; Calcium-Binding Proteins; Cells, Cultured; Consensus Sequence; Down-Regulation; Enkephalins; Heart; Hyperalgesia; Inflammation; Kv Channel-Interacting Proteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neurons; Physical Stimulation; Presenilin-1; Presenilin-2; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Repressor Proteins; Spinal Cord; Stimulation, Chemical; Transcription, Genetic

2002
II - Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists.
    Prostaglandins, 1979, Volume: 18, Issue:2

    Topics: Analgesics; Animals; Barium; Bucladesine; Endorphins; Enkephalins; Hyperalgesia; Hyperesthesia; Ionophores; Isoproterenol; Lidocaine; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Nociceptors; Pentazocine; Prostaglandins E; Rats

1979
III - Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid-antagonists.
    Prostaglandins, 1979, Volume: 18, Issue:2

    Topics: Analgesics; Animals; Carrageenan; Enkephalins; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Intraventricular; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Nociceptors; Pentazocine; Prostaglandins E; Rats

1979
Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli.
    Science (New York, N.Y.), 1977, Nov-18, Volume: 198, Issue:4318

    Topics: Animals; Circadian Rhythm; Endorphins; Enkephalins; Hot Temperature; Hyperalgesia; Hyperesthesia; Mice; Naloxone; Reaction Time

1977
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes

1992
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
    European journal of pharmacology, 1992, Aug-25, Volume: 219, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Inflammation; Injections, Spinal; Ketamine; Kynurenic Acid; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine

1992
Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:5

    Topics: Animals; Animals, Newborn; Capsaicin; Dynorphins; Enkephalins; Female; Foot Diseases; Gene Expression; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Substance P

1992
Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms.
    European journal of pharmacology, 1991, Mar-05, Volume: 194, Issue:2-3

    Topics: Adrenergic alpha-Antagonists; Animals; Carrageenan; Clonidine; Enkephalins; Hyperalgesia; Inflammation; Male; Morphine; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord

1991
Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord.
    Brain research. Molecular brain research, 1989, Volume: 6, Issue:1

    Topics: Animals; Dynorphins; Enkephalins; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; RNA, Messenger; Spinal Cord

1989
Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization.
    Brain research, 1988, Jul-12, Volume: 455, Issue:2

    Topics: Animals; DNA; Dynorphins; Enkephalin, Methionine; Enkephalins; Hyperalgesia; Hyperesthesia; Male; Nucleic Acid Hybridization; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger

1988
Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia.
    Journal of controlled release : official journal of the Controlled Release Society, 2018, 01-28, Volume: 270

    Topics: Analgesia; Analgesics; Animals; Brain; Conditioning, Psychological; Drug Tolerance; Enkephalin, Leucine; Hyperalgesia; Male; Morphine; Nanoparticles; Pain; Rats, Sprague-Dawley

2018
A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine.
    Science advances, 2019, Volume: 5, Issue:2

    Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Enkephalin, Leucine; Hyperalgesia; Male; Mice; Molecular Structure; Morphine; Nanoparticles; Rats; Squalene; Theranostic Nanomedicine; Tissue Distribution

2019
Hyperalgesia produced by intrathecal opioid antagonists depends on receptor selectivity and noxious stimulus.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesia; Animals; Benzomorphans; Enkephalin, Leucine; Hyperalgesia; Hyperesthesia; Injections, Spinal; Male; Morphinans; Naloxone; Narcotic Antagonists; Pain; Rats; Receptors, Opioid

1986