(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide and Allodynia

Topics: Acrylamides; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Humans; Hyperalgesia; Inflammation; Motor Activity; Neurons; Pain Measurement; Patch-Clamp Techniques; Protons; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Transfection

Topics: Administration, Oral; Aminoquinolines; Analgesics; Animals; Biological Availability; Body Temperature; CHO Cells; Cricetinae; Cricetulus; Humans; Hyperalgesia; Injections, Intravenous; Male; Models, Molecular; Molecular Conformation; Pyrimidines; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia; Male; Mice, Inbred C57BL; Oxidopamine; Pain Threshold; Parkinson Disease; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin; Signal Transduction; Trigeminal Caudal Nucleus; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Paclitaxel; Rats; RNA, Small Interfering; Spinal Cord; TRPV Cation Channels; Up-Regulation

Topics: Acrylamides; Animals; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Estradiol; Female; Fluorescent Antibody Technique; Hyperalgesia; Neurons, Afferent; Ovariectomy; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; TRPV Cation Channels

Topics: Acetanilides; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Acrylamides; Amiloride; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Male; Mice; Morphine; Pain Measurement; Purines; Random Allocation; Receptors, Atrial Natriuretic Factor; Receptors, Opioid; Stomach Ulcer; Transient Receptor Potential Channels; Visceral Pain

Topics: Acrylamides; Animals; Animals, Newborn; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Phototoxic; Disease Models, Animal; Evoked Potentials; HEK293 Cells; Humans; Hyperalgesia; Lidocaine; Lipid Metabolism; Menthol; Mice; Mice, Inbred C57BL; Neurons; Pain; Pain Threshold; Photochemotherapy; Reactive Oxygen Species; TRPV Cation Channels

Topics: Acrylamides; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Binding Proteins; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fish Venoms; Ganglia, Spinal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Hyperalgesia; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurogenic Inflammation; Oncogene Proteins v-fos; Pain; Pain Measurement; Sensory Receptor Cells; Time Factors; Touch; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Pain Measurement; Piperidines; Quinazolines; Quinuclidines; Receptors, Calcitonin Gene-Related Peptide; Repressor Proteins; TRPA1 Cation Channel; TRPV Cation Channels

Topics: Acetone; Acrolein; Acrylamides; Acute Disease; Alkaloids; Analgesics; Animals; Aporphines; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Chronic Pain; Cold Temperature; Freund's Adjuvant; Gene Expression; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Transient Receptor Potential Channels; TRPA1 Cation Channel

Topics: Acids; Acrylamides; Adenosine Diphosphate; Animals; Benzophenanthridines; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Diterpenes; Hindlimb; Hot Temperature; Hyperalgesia; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Injections; Ion Channels; Ischemia; Pain; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Sodium Chloride; Thrombosis; Tissue Extracts; TRPV Cation Channels

Topics: Acid Sensing Ion Channels; Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Hyperalgesia; Male; Masseter Muscle; Neurons; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Trigeminal Ganglion; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Communication; Complement C5a; Female; Hot Temperature; Hyperalgesia; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nerve Growth Factor; Nociceptors; Physical Stimulation; Signal Transduction; TRPV Cation Channels

Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Freund's Adjuvant; Gene Expression Profiling; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Masseter Muscle; Myalgia; Nerve Tissue Proteins; Pain Threshold; Principal Component Analysis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Statistics, Nonparametric; Time Factors; Trigeminal Ganglion; TRPV Cation Channels

Topics: Acrylamides; Adjuvants, Immunologic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fluorescent Antibody Technique; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Neurons; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; TRPV Cation Channels

Topics: Acrylamides; Afferent Pathways; Animals; Ankyrins; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Hyperalgesia; Injections, Intramuscular; Male; Masticatory Muscles; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels

Topics: Acrylamides; Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Enzyme Inhibitors; Female; Fluorescent Dyes; Heat Stress Disorders; Hyperalgesia; Lipoxygenase; Nitric Oxide Synthase; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Purinergic P2; Receptors, Purinergic P2X; TRPV Cation Channels

Topics: Acrylamides; Analysis of Variance; Animals; Area Under Curve; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Mice; Oligodeoxyribonucleotides, Antisense; Pain Threshold; Physical Stimulation; RNA, Messenger; Spinal Cord; Transient Receptor Potential Channels; TRPA1 Cation Channel

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea

Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Capsaicin; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Humans; Hyperalgesia; Inflammation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nifedipine; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Plant Oils; Pregnenolone; Sensory Receptor Cells; Telemetry; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPM Cation Channels

Topics: Acrylamides; Analgesics; Animals; Arachidonic Acids; Area Under Curve; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Oligopeptides; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Spinal Cord; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Hyperalgesia; Male; Masseter Muscle; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells; Signal Transduction; Trigeminal Ganglion; TRPV Cation Channels

Topics: Acrylamides; Anesthetics, Local; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Cells, Cultured; Hyperalgesia; Male; Masseter Muscle; Phosphorylation; Purinergic P2X Receptor Agonists; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Sensory Receptor Cells; Sensory System Agents; Skin; Touch; Trigeminal Ganglion; TRPV Cation Channels

Topics: Acrylamides; Animals; Bradykinin Receptor Antagonists; Bridged Bicyclo Compounds, Heterocyclic; Hyperalgesia; Kallidin; Male; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; TRPV Cation Channels