sb 203580 has been researched along with Allodynia in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (28.89) | 29.6817 |
| 2010's | 30 (66.67) | 24.3611 |
| 2020's | 2 (4.44) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Fan, R; Gong, X; Ye, X; Zhang, M; Zhu, Q | 1 |
| Chen, D; Fang, Q; Li, N; Qiu, Y; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, N; Zhang, Q; Zhang, R; Zhang, T | 1 |
| Beitz, AJ; Kaang, BK; Kim, YH; Ko, HG; Kwon, SG; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Chen, CH; Chen, NF; Chen, WF; Feng, CW; Huang, SY; Sung, CS; Wen, ZH; Wong, CS | 1 |
| Domoto, R; Kawabata, A; Nakashima, K; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H; Yamanishi, H; Yamasoba, D | 1 |
| Beggs, S; Moriarty, O; Salter, MW; Sengar, AS; Tu, Y; Walker, SM | 1 |
| Beitz, AJ; Choi, SR; Lee, JH | 1 |
| Akhtari, Z; Manaheji, H; Tekieh, E; Zaringhalam, J | 1 |
| Bender, DE; Cheng, HT; Dauch, JR; Hsieh, W; Kelly, ZA; Luna-Wong, LA; Yanik, BM | 1 |
| Chen, JS; Gong, QJ; Huang, QD; Li, YY; Lu, ZH; Wei, XH | 1 |
| Akhtari, Z; Eidi, A; Ruhani, AH; Tekieh, E; Zaringhalam, J | 1 |
| Ding, G; Fu, J; Hua, LM; Ji, YH; Jiang, F; Jiao, YL; Niu, QS | 1 |
| Ho, I; Kotani, J; Mei, XP; Sakuma, Y; Wu, D; Xie, C; Xu, LX | 1 |
| Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 2 |
| Chang, JH; Chen, JY; Chen, KB; Hsu, SF; Tsai, SY; Wen, YR; Zeng, YJ | 1 |
| Chen, ZG; Huang, JL; Kong, FJ; Lu, JM; Shun, JL; Yang, BX; Zhang, HH | 1 |
| Du, JY; Fang, JF; Fang, JQ; Liang, Y; Liu, J; Qiu, YJ | 1 |
| Chu, YX; Huang, B; Li, HB; Liu, MJ; Ni, HD; Wang, HQ; Xu, LS; Xu, SJ; Yao, M; Zheng, Y | 1 |
| Beitz, AJ; Kim, SJ; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Cao, L; Malon, JT | 1 |
| Chen, G; Deng, L; Song, F; Zhang, L; Zhao, H; Zhu, H | 1 |
| Chen, C; Meng, QX; Qi, J; Wu, H; Wu, Y; Zhao, TB | 1 |
| Bradesi, S; Mayer, EA; Pothoulakis, C; Steinauer, J; Svensson, CI; Yaksh, TL | 1 |
| Hsin, ST; Lin, SL; Shen, CH; Tai, YH; Tsai, RY; Tzeng, JI; Wang, CB; Wong, CS; Yang, CP | 1 |
| Ito, N; Obata, H; Saito, S | 1 |
| Burstein, R; Kainz, V; Levy, D; Zhang, XC | 1 |
| Chen, Z; Doyle, T; Muscoli, C; Obeid, LM; Salvemini, D | 1 |
| Gao, YJ; Huang, L; Strichartz, G; Wang, J | 1 |
| Chu, H; Gao, J; Xia, J; Yang, Z | 1 |
| Ahn, DK; Ahn, MH; Bae, YC; Han, SR; Ju, JS; Kim, MJ; Yang, GY | 1 |
| Chu, H; Gao, J; Liu, S; Xia, J; Xu, H; Yang, Z | 1 |
| Kondo, T; Miwa, H; Noguchi, K; Sakurai, J | 1 |
| Lyons, D; Ma, F; Westlund, KN; Zhang, L | 1 |
| Amaya, F; Izumi, Y; Miura, M; Mizukoshi, K; Sasaki, M; Watanabe, M | 1 |
| Ji, RR; Jin, SX; Woolf, CJ; Zhuang, ZY | 1 |
| Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL | 1 |
| Dai, Y; Fukuoka, T; Katsura, H; Kobayashi, K; Mizushima, T; Noguchi, K; Obata, K; Tokunaga, A; Yamanaka, H | 1 |
| Dai, Y; Fukuoka, T; Mizushima, T; Noguchi, K; Obata, K; Tokunaga, A; Yamanaka, H | 1 |
| Calixto, JB; Motta, EM; Rae, GA | 1 |
| Ge, YX; Li, YY; Liu, XG; Liu, YL; Wei, XH; Wu, CY; Xin, WJ; Xu, JT; Zang, Y; Zhang, T | 1 |
| Bruchas, MR; Chavkin, C; Gendron, L; Ippolito, DL; Xu, M | 1 |
| Ahn, DK; Han, SR; Jeon, HJ; Ju, JS; Lee, MK; Lim, EJ; Yang, GY | 1 |
| Chen, J; Cui, XY; Dai, Y; Kobayashi, K; Noguchi, K; Obata, K; Wang, SL; Yamanaka, H | 1 |
| Davis, A; Fox, A; Ganju, P; Núñez, X; Patel, S | 1 |
45 other study(ies) available for sb 203580 and Allodynia
| Article | Year |
|---|---|
Exercise Reduces Morphine-Induced Hyperalgesia and Antinociceptive Tolerance.
Topics: Analgesics; Animals; Hyperalgesia; Imidazoles; Male; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Physical Conditioning, Animal; Pyridines; Rats, Wistar; Spinal Cord Dorsal Horn | 2021 |
Spinal endomorphins attenuate burn-injury pain in male mice by inhibiting p38 MAPK signaling pathway through the mu-opioid receptor.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Burns; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Imidazoles; Injections, Spinal; Male; Mice; Mice, Knockout; Narcotic Antagonists; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Pain; Pyridines; Receptors, Opioid, mu; Signal Transduction; Spinal Cord Injuries | 2021 |
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Flavonoids; Hyperalgesia; Imidazoles; MAP Kinase Signaling System; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Nociception; Pain; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Spinal Cord | 2017 |
Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hot Temperature; Hyperalgesia; Imidazoles; Interleukin-1beta; Male; Microglia; Minocycline; Neurons; Nitric Oxide; Nociceptive Pain; Phosphorylation; Pyridines; Random Allocation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2017 |
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk.
Topics: Acetylcysteine; Animals; Antibodies; Cells, Cultured; Clodronic Acid; Coculture Techniques; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Imidazoles; Macrophages; Male; Membrane Proteins; Mice; Minocycline; Neurons; p300-CBP Transcription Factors; Paclitaxel; Peripheral Nervous System Diseases; Phosphoproteins; Phosphorylation; Proline; Pyridines; Pyruvates; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, CXCR4; Recombinant Proteins; Sciatic Nerve; Thiocarbamates; Thrombomodulin; Up-Regulation | 2018 |
Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats.
Topics: Animals; Enzyme Inhibitors; Female; Hyperalgesia; Imidazoles; Interferon Regulatory Factors; Male; Microglia; Minocycline; Neurons; Pain; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Sex Factors; Spinal Cord | 2019 |
Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation.
Topics: Animals; Astrocytes; Constriction, Pathologic; Disease Models, Animal; Hyperalgesia; Imidazoles; Ketoconazole; Lumbar Vertebrae; Male; Mice; Microglia; Neuralgia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Spinal Cord; Spinal Cord Dorsal Horn; Steroid 17-alpha-Hydroxylase | 2019 |
Cellular events during arthritis-induced hyperalgesia are mediated by interleukin-6 and p38 MAPK and their effects on the expression of spinal mu-opioid receptors.
Topics: Animals; Arthritis, Experimental; Hyperalgesia; Imidazoles; Interleukin-6; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord | 2013 |
Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Surface; CD58 Antigens; Data Interpretation, Statistical; Diabetic Neuropathies; Hyperalgesia; Imidazoles; Immunohistochemistry; Langerhans Cells; Lectins, C-Type; Male; Mannose-Binding Lectins; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Nerve Growth Factors; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptor, trkA; Tumor Necrosis Factor-alpha | 2013 |
Src/p38 MAPK pathway in spinal microglia is involved in mechanical allodynia induced by peri-sciatic administration of recombinant rat TNF-α.
Topics: Animals; Hyperalgesia; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Microglia; p38 Mitogen-Activated Protein Kinases; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; src-Family Kinases; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Relationship between serum IL10 level and p38MAPK enzyme activity on behavioral and cellular aspects of variation of hyperalgesia during different stages of arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Arthritis, Experimental; Hyperalgesia; Imidazoles; Inflammation; Interleukin-10; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptors, Opioid, mu | 2014 |
Microglial activation of p38 contributes to scorpion envenomation-induced hyperalgesia.
Topics: Animals; Behavior, Animal; Hyperalgesia; Imidazoles; Lumbosacral Region; Male; Microglia; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Spinal Cord | 2013 |
Depressing interleukin-1β contributed to the synergistic effects of tramadol and minocycline on spinal nerve ligation-induced neuropathic pain.
Topics: Analgesics; Animals; Antibodies; Drug Combinations; Hyperalgesia; Imidazoles; Interleukin-1beta; Ligation; Male; Microglia; Minocycline; Neuralgia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Posterior Horn Cells; Pyridines; Rats, Sprague-Dawley; Rotarod Performance Test; Signal Transduction; Spinal Nerves; Tramadol | 2014 |
Blockade of peripheral P2Y1 receptors prevents the induction of thermal hyperalgesia via modulation of TRPV1 expression in carrageenan-induced inflammatory pain rats: involvement of p38 MAPK phosphorylation in DRGs.
Topics: Adenosine Diphosphate; Animals; Carrageenan; Deoxyadenine Nucleotides; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Imidazoles; Inflammation; Male; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Pain; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Touch; TRPV Cation Channels | 2014 |
Spinal p38 activity and analgesic effect after low- and high-intensity electroacupuncture stimulation in a plantar incision rat model.
Topics: Acupuncture Analgesia; Animals; Electroacupuncture; Hindlimb; Hyperalgesia; Imidazoles; Injections, Spinal; Male; Microglia; Nociceptive Pain; p38 Mitogen-Activated Protein Kinases; Pain, Postoperative; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Rats, Sprague-Dawley; Spinal Cord | 2015 |
Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia.
Topics: Animals; Cyclin-Dependent Kinase 5; Freund's Adjuvant; Hyperalgesia; Imidazoles; Male; MAP Kinase Signaling System; Microglia; Myelitis; Neurons; Purines; Pyridines; Rats; Rats, Sprague-Dawley; Roscovitine; Spinal Cord Dorsal Horn; Tumor Necrosis Factor-alpha | 2015 |
Electroacupuncture attenuates spinal nerve ligation-induced microglial activation mediated by p38 mitogen-activated protein kinase.
Topics: Animals; Biomarkers; CD11b Antigen; Electroacupuncture; Fluorescent Antibody Technique; Hyperalgesia; Imidazoles; Ligation; Male; Microglia; Neuroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Posterior Horn Cells; Pyridines; Rats, Sprague-Dawley; Spinal Nerves | 2016 |
Glial activation in the periaqueductal gray promotes descending facilitation of neuropathic pain through the p38 MAPK signaling pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Binding Proteins; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hyperalgesia; Imidazoles; Male; Microfilament Proteins; Neuroglia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Periaqueductal Gray; Phosphopyruvate Hydratase; Pyridines; Rats; Rats, Sprague-Dawley; Sciatica; Signal Transduction; Time Factors | 2016 |
Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antineoplastic Agents; Blood Pressure; Clonidine; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Imidazoles; Male; Mice; Motor Activity; Organoplatinum Compounds; Oxaliplatin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Spinal Cord; Spinal Cord Dorsal Horn | 2016 |
Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Cells, Cultured; Chemokine CCL5; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalgesia; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neuroglia; Pain Threshold; Peptide Fragments; Peripheral Nerve Injuries; Pyridines; Spinal Cord; Spinal Nerves | 2016 |
The role of p38MAPK activation in spinal dorsal horn in remifentanil-induced postoperative hyperalgesia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Enzyme Activation; Hyperalgesia; Imidazoles; Male; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pain, Postoperative; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Remifentanil; Spinal Cord Dorsal Horn; Time Factors | 2016 |
Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia.
Topics: Animals; Genes, fos; Hyperalgesia; Imidazoles; Interleukin-6; Male; Microglia; Minocycline; Neurons; Pain; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Dorsal Horn; Stress, Physiological | 2016 |
Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Imidazoles; Male; Microglia; Minocycline; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Nerves; Stress, Physiological; Up-Regulation; Viscera; Water Deprivation | 2009 |
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.
Topics: Amino Acid Transport System X-AG; Animals; Enzyme Inhibitors; Excitatory Amino Acids; Hyperalgesia; Imidazoles; Male; MAP Kinase Signaling System; Microglia; Morphine; Naloxone; Narcotic Antagonists; Narcotics; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyridines; Random Allocation; Rats; Rats, Wistar; Spinal Cord | 2009 |
Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; CD11b Antigen; Enzyme Inhibitors; Fluorescent Antibody Technique; Hyperalgesia; Imidazoles; Immunohistochemistry; Male; Microglia; Minocycline; p38 Mitogen-Activated Protein Kinases; Pain; Pain, Postoperative; Peripheral Nervous System Diseases; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2009 |
Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions.
Topics: Action Potentials; Animals; Cyclooxygenase 1; Disease Models, Animal; Dura Mater; Endothelial Cells; Enzyme Inhibitors; Hyperalgesia; Imidazoles; Male; Membrane Proteins; p38 Mitogen-Activated Protein Kinases; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor, Type I; Sensory Receptor Cells; Time Factors; Trigeminal Ganglion; Tumor Necrosis Factor-alpha | 2011 |
Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.
Topics: Animals; Antibodies, Monoclonal; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Extremities; Hot Temperature; Hyperalgesia; Imidazoles; Injections; Male; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes; Touch | 2011 |
Shifts in cell-type expression accompany a diminishing role of spinal p38-mapkinase activation over time during prolonged postoperative pain.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Hyperalgesia; Imidazoles; Immunohistochemistry; Male; Microglia; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain, Postoperative; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Time | 2011 |
Melanocortin 4 receptor induces hyperalgesia and allodynia after chronic constriction injury by activation of p38 MAPK in DRG.
Topics: Animals; Enzyme Activation; Ganglia, Spinal; Hyperalgesia; Imidazoles; Injections, Spinal; Male; Neuralgia; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Melanocortin, Type 4; Sciatic Nerve; Signal Transduction | 2012 |
Blockade of microglial activation reduces mechanical allodynia in rats with compression of the trigeminal ganglion.
Topics: Animals; Hyperalgesia; Imidazoles; Male; Microglia; Nerve Compression Syndromes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion | 2012 |
Melanocortin 4 receptor mediates neuropathic pain through p38MAPK in spinal cord.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Drug Delivery Systems; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hyperalgesia; Imidazoles; Male; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Peptides, Cyclic; Pyridines; Rats; Rats, Wistar; Receptor, Melanocortin, Type 4; Sciatica; Spinal Cord; Time Factors | 2012 |
Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Enzyme Activation; Ganglia, Spinal; Hyperalgesia; Imidazoles; Male; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; TRPA1 Cation Channel; TRPC Cation Channels; Visceral Pain | 2013 |
Orofacial neuropathic pain mouse model induced by Trigeminal Inflammatory Compression (TIC) of the infraorbital nerve.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Facial Pain; Hyperalgesia; Imidazoles; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Nerve Compression Syndromes; Neuralgia; Neurons; Orbit; p38 Mitogen-Activated Protein Kinases; Purinergic P2X Receptor Antagonists; Pyridines; Tetrazoles; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Neuralgia; Trigeminal Nucleus, Spinal | 2012 |
Activation of p38 mitogen-activated protein kinase in the dorsal root ganglion contributes to pain hypersensitivity after plantar incision.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enzyme Activation; Ganglia, Spinal; Hyperalgesia; Imidazoles; Injections, Spinal; Male; Neurons; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Rats | 2013 |
Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Hyperalgesia; Imidazoles; Male; Mice; Mice, Inbred ICR; Morpholines; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sciatica; Sigma-1 Receptor; Spinal Cord | 2013 |
p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.
Topics: Animals; Behavior, Animal; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Imidazoles; Injections, Spinal; Ligation; Male; Microglia; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
Topics: Animals; Anthracenes; Brain-Derived Neurotrophic Factor; Butadienes; Enzyme Activation; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Imidazoles; Ion Channels; JNK Mitogen-Activated Protein Kinases; Ligation; Lumbar Vertebrae; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Nerves; Stress, Mechanical; TRPV Cation Channels | 2004 |
Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats.
Topics: Activating Transcription Factor 3; Animals; Antibodies; Behavior, Animal; Brain-Derived Neurotrophic Factor; Butadienes; Cell Count; Constriction; Drug Interactions; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Imidazoles; Immunohistochemistry; In Situ Hybridization; Male; Nerve Growth Factor; Neurons; Neuropeptide Y; Nitriles; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Time Factors; Transcription Factors | 2004 |
Mechanical hyperalgesia induced by endothelin-1 in rats is mediated via phospholipase C, protein kinase C, and MAP kinases.
Topics: Animals; Endothelin-1; Enzyme Inhibitors; Estrenes; Hyperalgesia; Imidazoles; Indoles; Injections, Intradermal; Male; Maleimides; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Reaction Time; Signal Transduction; Type C Phospholipases | 2006 |
p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury.
Topics: Animals; Denervation; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Hypesthesia; Imidazoles; Immunohistochemistry; Lumbosacral Region; Male; Microglia; Motor Neurons; Nerve Fibers; Neuralgia; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Thalidomide; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Hyperesthesia; Imidazoles; In Vitro Techniques; Ligation; Lumbar Vertebrae; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Opioid, kappa; Sciatic Nerve; Spinal Cord | 2007 |
Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats.
Topics: Animals; Behavior, Animal; Body Weight; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Facial Pain; Flavonoids; Functional Laterality; Hyperalgesia; Imidazoles; Male; Physical Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Time Factors | 2007 |
Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.
Topics: Animals; Bee Venoms; Butadienes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Hypersensitivity; Imidazoles; Immunohistochemistry; Inflammation; Male; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord | 2008 |
p38 stress-activated protein kinase inhibitor reverses bradykinin B(1) receptor-mediated component of inflammatory hyperalgesia.
Topics: Animals; Cell Line; Cyclooxygenase 2; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hindlimb; Humans; Hyperalgesia; Imidazoles; Inflammation; Interleukin-1; Isoenzymes; Kallidin; Male; Membrane Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptors, Bradykinin; Tumor Necrosis Factor-alpha | 2001 |