Page last updated: 2024-12-07

nonyl-4-hydroxyquinoline-n-oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID130804
CHEMBL ID1235570
CHEMBL ID4792151
SCHEMBL ID4946320
SCHEMBL ID21065470
MeSH IDM0056023

Synonyms (21)

Synonym
316-66-5
4-quinolinol, 2-nonyl-, 1-oxide
nq-n-oxide
nqno
nonyl-4-hydroxyquinoline-n-oxide
CHEMBL1235570
2-nonyl-4-hydroxyquinoline n-oxide
1NU1
2-n-nonyl-4-hydroxyquinoline-n-oxide
DB08453
2-nonyl-4-quinolinol 1-oxide
1-hydroxy-2-nonylquinolin-4(1h)-one
1-hydroxy-2-nonylquinolin-4-one
SCHEMBL4946320
2-nonylquinolin-4-ol 1-oxide
Q27097658
CHEMBL4792151
SCHEMBL21065470
DTXSID00953562
PD004386
PD180638
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain C, Cytochrome bBos taurus (cattle)Kd0.06400.06400.06400.0640AID977611
Chain C, Cytochrome bBos taurus (cattle)Kd0.06400.06400.06400.0640AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2003Biochemistry, Aug-05, Volume: 42, Issue:30
Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site.
AID1374543Mutagenicity in Salmonella typhimurium TA100 assessed as revertant colonies at 0.5 uM by Ames test2018Bioorganic & medicinal chemistry letters, 03-01, Volume: 28, Issue:5
MF-8, a novel promising arylpiperazine-hydantoin based 5-HT
AID1332258Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay2017Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
Biotransformation of isofraxetin-6-O-β-d-glucopyranoside by Angelica sinensis (Oliv.) Diels callus.
AID1568847Mutagenicity in Salmonella typhimurium TA100 assessed as increase in revertant colonies at 0.5 uM preincubated for 90 mins and measured after 72 hrs by Ames test2019European journal of medicinal chemistry, Sep-15, Volume: 178Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT
AID1332259Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability at 10 uM after 24 hrs in presence of LPS by MTT assay2017Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2
Biotransformation of isofraxetin-6-O-β-d-glucopyranoside by Angelica sinensis (Oliv.) Diels callus.
AID1568844Mutagenicity in Salmonella typhimurium TA100 assessed as fold increase over MCB at 0.5 uM preincubated for 90 mins and measured after 72 hrs by Ames test2019European journal of medicinal chemistry, Sep-15, Volume: 178Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT
AID1674266Cytotoxicity against human HeLa cells assessed as reduction in cell viability2020Journal of natural products, 07-24, Volume: 83, Issue:7
Isolation of 2-Alkyl-4-quinolones with Unusual Side Chains from a Chinese
AID1674264Antibacterial activity against Staphylococcus epidermidis2020Journal of natural products, 07-24, Volume: 83, Issue:7
Isolation of 2-Alkyl-4-quinolones with Unusual Side Chains from a Chinese
AID1674265Antibacterial activity against Staphylococcus aureus2020Journal of natural products, 07-24, Volume: 83, Issue:7
Isolation of 2-Alkyl-4-quinolones with Unusual Side Chains from a Chinese
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (29.63)18.7374
1990's3 (11.11)18.2507
2000's9 (33.33)29.6817
2010's6 (22.22)24.3611
2020's1 (3.70)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.23 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]