Compounds > 2-(3-trifluoromethylphenyl)histamine
Page last updated: 2024-11-10

2-(3-trifluoromethylphenyl)histamine

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Description

2-(3-trifluoromethylphenyl)histamine: a selective histamine H1-receptor agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5310982
CHEMBL ID24665
SCHEMBL ID3012997
MeSH IDM0244680

Synonyms (10)

Synonym
2-[3-(trifluoromethyl)phenyl]histamine
NCGC00165906-01
CHEMBL24665 ,
L000054
2-[2-[3-(trifluoromethyl)phenyl]-1h-imidazol-5-yl]ethanamine
2-(3-trifluoromethylphenyl)histamine
bdbm50403672
SCHEMBL3012997
2-(3-(trifluormethyl)phenyl)-histamine
nfuyvkmagijykb-uhfffaoysa-n
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Histamine H1 receptorRattus norvegicus (Norway rat)IC50 (µMol)1.00000.00000.32271.2589AID87362
Histamine H1 receptorRattus norvegicus (Norway rat)Ki251,189,002,240.00000.00071.54406.5000AID87372
Histamine H1 receptorHomo sapiens (human)IC50 (µMol)1.00000.00000.44365.1768AID87362
Histamine H1 receptorHomo sapiens (human)Ki251,189,002,240.00000.00000.511010.0000AID87372
Histamine H4 receptorHomo sapiens (human)Ki1.25890.00060.478710.0000AID548981
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Histamine H1 receptorCavia porcellus (domestic guinea pig)Kd0.00100.00080.12280.9550AID86904
Histamine H1 receptorHomo sapiens (human)EC50 (µMol)0.25120.00040.18810.7943AID548979
Histamine H4 receptorHomo sapiens (human)EC50 (µMol)1.58490.00740.601610.0000AID548982
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
inflammatory responseHistamine H1 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathwayHistamine H1 receptorHomo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayHistamine H1 receptorHomo sapiens (human)
memoryHistamine H1 receptorHomo sapiens (human)
visual learningHistamine H1 receptorHomo sapiens (human)
regulation of vascular permeabilityHistamine H1 receptorHomo sapiens (human)
positive regulation of vasoconstrictionHistamine H1 receptorHomo sapiens (human)
regulation of synaptic plasticityHistamine H1 receptorHomo sapiens (human)
cellular response to histamineHistamine H1 receptorHomo sapiens (human)
G protein-coupled serotonin receptor signaling pathwayHistamine H1 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerHistamine H1 receptorHomo sapiens (human)
chemical synaptic transmissionHistamine H1 receptorHomo sapiens (human)
inflammatory responseHistamine H4 receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationHistamine H4 receptorHomo sapiens (human)
biological_processHistamine H4 receptorHomo sapiens (human)
regulation of MAPK cascadeHistamine H4 receptorHomo sapiens (human)
G protein-coupled serotonin receptor signaling pathwayHistamine H4 receptorHomo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayHistamine H4 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerHistamine H4 receptorHomo sapiens (human)
chemical synaptic transmissionHistamine H4 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
histamine receptor activityHistamine H1 receptorHomo sapiens (human)
G protein-coupled serotonin receptor activityHistamine H1 receptorHomo sapiens (human)
neurotransmitter receptor activityHistamine H1 receptorHomo sapiens (human)
histamine receptor activityHistamine H4 receptorHomo sapiens (human)
G protein-coupled serotonin receptor activityHistamine H4 receptorHomo sapiens (human)
G protein-coupled acetylcholine receptor activityHistamine H4 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
cytosolHistamine H1 receptorHomo sapiens (human)
plasma membraneHistamine H1 receptorHomo sapiens (human)
synapseHistamine H1 receptorHomo sapiens (human)
dendriteHistamine H1 receptorHomo sapiens (human)
plasma membraneHistamine H1 receptorHomo sapiens (human)
plasma membraneHistamine H4 receptorHomo sapiens (human)
plasma membraneHistamine H4 receptorHomo sapiens (human)
dendriteHistamine H4 receptorHomo sapiens (human)
synapseHistamine H4 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID86901Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID87056Contractile effects on guinea pig aorta as histamine H1 receptor agonism1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID548982Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay2010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
Histamine H4 receptor agonists.
AID87372Inhibitory activity against human Histamine H1 receptor2003Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.
AID86276In vivo binding of H1 receptor Agonists measured by binding of [3H]mepyramine to Mouse cerebral cortex at the dosage of ( 100 mg/kg(no. of mice treated= 3 )1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID86904Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86603H1-Histamine receptor agonism on guinea pig ileum as intrinsic activity given as 1.0 with respect to histamine (paired 't'test; p>0.05).1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID86406In vivo binding of H1 receptor Agonists measured by binding of [3H]mepyramine to Mouse cerebral cortex at the dosage of ( 30 mg/kg(no. of mice treated= 5 )1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID87058The H1 receptor-mediated nature of the ileum contractionhas been verified by competition experiments with the H1 receptor antagonist mepyramine1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID101737Compound was tested for its agonist activity against M3-acetylcholine receptor of guinea pig ileum.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86750Contractile effect on isolated guinea pig ileal segments is a measure of H1 (histamine) receptor agonistic activity relative to histamine.1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID88160Histamine H2 receptor agonism activity was determined on the isolated Guinea pig Atrium was determined as pD'21995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID86749Contractile effect on isolated guinea pig aorta is a measure of H1 (histamine) receptor agonistic activity relative to histamine1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID88002Histamine H2 receptor agonism activity was determined on the isolated Guinea pig Atrium was determined as Intrinsic activity with respect to Histamine1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID86926H1-Histamine receptor agonism on Guinea pig aorta was evaluated (SEM 0.03-0.18)1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID548990Selectivity ratio of EC50 for human histamine H1 receptor to EC50 for human histamine H4 receptor2010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
Histamine H4 receptor agonists.
AID86407In vivo binding of H1 receptor Agonists measured by binding of [3H]-Mepyramine to Mouse cerebral cortex at the dosage of ( 300 mg/kg(no. of mice treated= 3 )1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID86405In vivo binding of H1 receptor Agonists measured by binding of [3H]mepyramine to Mouse cerebral cortex at the dosage of ( 3 mg/kg(no. of mice treated=5 )1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID88167Compound was tested for agonist activity against histamine H2 receptor of guinea pig atrium1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86416Compound was tested for its partial agonist activity in the presence of 1 nM mepyramine against Histamine H1 receptor in guinea pig ileum.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86418Compound was tested for its partial agonist activity in the presence of 10 nM mepyramine against Histamine H1 receptor in guinea pig ileum.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID87070Compound was tested for binding affinity against guinea pig ileum1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID548983Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay relative to histamine2010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
Histamine H4 receptor agonists.
AID87227Intrinsic activity was determined2003Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.
AID86419Compound was tested for its partial agonist activity in the presence of 100 nM mepyramine against Histamine H1 receptor in guinea pig ileum.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86917Contractile effect on isolated guinea pig ileal segments by H1 (histamine) receptor agonism.1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID548979Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay2010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
Histamine H4 receptor agonists.
AID548980Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay relative to histamine2010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
Histamine H4 receptor agonists.
AID86598H1-Histamine receptor agonism on Guinea pig aorta was evaluated as Intrinsic activity given as 1.0 with respect to histamine (paired 't'test;p>0.05)1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID87362Inhibitory activity against human Histamine H1 receptor2003Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.
AID86424Partial agonist activity against Histamine H1 receptor in guinea pig aorta1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID548981Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma22010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
Histamine H4 receptor agonists.
AID86425Partial agonist activity against Histamine H1 receptor in guinea pig ileum.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86754Relative potency against Histamine H1 receptor of guinea pig aorta1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86753Relative potency against Histamine H1 receptor in guinea pig ileum.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
AID86275In vivo binding of H1 receptor Agonists measured by binding of [3H]mepyramine to Mouse cerebral cortex at the dosage of ( 10 mg/kg(no. of mice treated=5 )1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
AID86288Compound was tested for the agonist activity against histamine H3 receptor of guinea pig ileum1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (41.67)18.2507
2000's4 (33.33)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.74 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		3.88120aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
n-methylhistamine
[no description available]		2.0510aralkylamine
betahistine
Betahistine: A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.. betahistine : An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.		1.9810aminoalkylpyridine;
secondary amino compound		H1-receptor agonist;
vasodilator agent
cimetidine
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.		2.0710aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
dimaprit
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.		2.0510imidothiocarbamic ester
imetit
imetit: structure given in first source. imetit : An imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.		2.0510imidazoles;
imidothiocarbamic ester		H3-receptor agonist;
H4-receptor agonist
piracetam
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.		210organonitrogen compound;
organooxygen compound
pyrilamine
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.. mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.		3.150aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
pyrimethamine
Maloprim: contains above 2 cpds		210aminopyrimidine;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
tripelennamine
Tripelennamine: A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.		2.0110aromatic amine
thiazoles
[no description available]		2.92401,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
metoprine
metoprine: histamine methyltransferase antagonist		210
4-methylhistamine
4-methylhistamine: RN given refers to parent cpd. 4-methylhistamine : An aralkylamino compound that is histamine bearing a methyl substituent at the 5 position on the ring.		2.4720aralkylamino compound;
imidazoles		histamine agonist;
metabolite
impromidine
Impromidine: A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.		2.0510
fura-2
Fura-2: A fluorescent calcium chelating agent which is used to study intracellular calcium in tissues.		2.0810
2-(2-aminoethyl)pyridine
2-(2-aminoethyl)pyridine: histamine H1 receptor agonist inducing cross-tolerance to histamine; RN given refers to parent cpd; structure		2.0110aminoalkylpyridine;
primary amine		histamine agonist;
metabolite
2-(2-aminoethyl)thiazole
2-(2-aminoethyl)thiazole: receptor H1 agonist; RN given refers to parent cpd		2.91401,3-thiazoles
2-methylhistamine
2-methylhistamine: RN given refers to parent cpd. 2-methylhistamine : An aralkylamino compound that is histamine bearing a methyl substituent at the 2 position on the ring.		2.4220aralkylamino compound;
imidazoles		histamine agonist;
metabolite
amthamine
amthamine: histamine H2 receptor agonist; structure & RN given in first source; RN given refers to parent cpd		2.4720thiazoles
iodoproxyfan
iodoproxyfan: structure given in first source		2.0510
alpha-methylhistamine
(R)-alpha-methylhistamine : An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position (the R-enantiomer).		2.0510aralkylamino compound;
imidazoles		H3-receptor agonist
imidazolyl-4-propylamine
imidazolyl-4-propylamine: structure given in first source		2.0510
inositol 1,4,5-trisphosphate
Inositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.		2.0210myo-inositol trisphosphatemouse metabolite
burimamide
Burimamide: An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.		2.0510imidazoles
4-(1h-imidazol-4-ylmethyl)piperidine
4-(1H-imidazol-4-ylmethyl)piperidine: structure in first source		2.0510piperidines
vuf 8430
S-(2-guanidylethyl)isothiourea: a histamine H4 receptor agonist; structure in first source		2.0510
jnj 7777120
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine: an H4 receptor antagonist; structure in first source		2.0710
proxyfan
[no description available]		2.0510benzyl ether
(2S)-1-(1H-imidazol-5-yl)-2-propanamine
[no description available]		2.0510aralkylamine
impentamine
impentamine: structure in first source		2.0510
4-(1H-imidazol-5-ylmethyl)pyridine
[no description available]		2.0510pyridines
methylhistaprodifen
[no description available]		2.0810
histaprodifen
[no description available]		2.0110
methimepip
methimepip: histamine H3 agonist		2.0510
scopolamine hydrobromide
[no description available]		210
4-(1h-imidazol-4-yl)butanamine
4-(1H-imidazol-4-yl)butanamine: agonist of both H3 and H4 histamine receptors; structure in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9810
Allergic Conjunctivitis
[description not available]		02.0710
Conjunctivitis, Allergic
Conjunctivitis due to hypersensitivity to various allergens.		02.0710
Allodynia
[description not available]		02.0210
Amnesia-Memory Loss
[description not available]		0210
Amnesia
Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)		0210