| ID Source | ID |
|---|---|
| PubMed CID | 443028 |
| CHEMBL ID | 454592 |
| CHEBI ID | 10088 |
| SCHEMBL ID | 635902 |
| MeSH ID | M0220556 |
| Synonym |
|---|
| o,o-dimethyllirioresinol b |
| lirioresinol b dimethyl ether |
| 1h,3h-furo(3,4-c)furan, tetrahydro-1,4-bis(3,4,5)-trimethoxyphenyl)-, 1alpha,3aalpha,4alpha,6aalpha)- |
| 1h,3h-furo(3,4-c)furan, tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-, (1s,3ar,4s,6ar)- |
| lirioresinol b, dimethyl- |
| yangabin |
| ( )-yangabin |
| lirioresinol b, o,o-dimethyl- |
| 1h,3h-furo(3,4-c)furan, 3aalpha,4,6,6aalpha-tetrahydro-1alpha,4alpha-bis(3,4,5-trimethoxyphenyl)- |
| ccris 8944 |
| lirioresinol-b dimethyl ether |
| 13060-14-5 |
| yangambin |
| CHEMBL454592 , |
| (+)-yangambin |
| (+)-syringaresinol dimethyl ether |
| chebi:10088 , |
| (3s,3ar,6s,6ar)-3,6-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan |
| (+)-yangabin |
| (+)-o,o-dimethyllirioresinol b |
| bdbm50443539 |
| SCHEMBL635902 |
| Q27108576 |
| HY-N4267 |
| CS-0032586 |
| tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-1h,3h-furo[3,4-c]furan |
| MS-28063 |
| DTXSID601025819 |
| AKOS040760764 |
| Class | Description |
|---|---|
| lignan | Any phenylpropanoid derived from phenylalanine via dimerization of substituted cinnamic alcohols, known as monolignols, to a dibenzylbutane skeleton. Note that while individual members of the class have names ending ...lignane, ...lignene, ...lignadiene, etc., the class names lignan, neolignan, etc., do not end with an "e". |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 (µMol) | 16.8200 | 0.0005 | 3.4984 | 9.7600 | AID1055972 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 0.6160 | 0.0000 | 0.9332 | 10.0000 | AID1657516 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1055970 | Increase in 2-NBDG uptake in mouse 3T3L1 cells after 30 mins by fluorescence spectrophotometry | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. |
| AID1657517 | Inhibition of acetylcholinesterase (unknown origin) at 0.01 to 100 uM using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 2 mins by Ellman's method relative to control | |||
| AID367127 | Inhibition of NO production in LPS-stimulated mouse BV2 cells assessed as nitrite accumulation after 20 hrs by Griess reagent method | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. |
| AID1055972 | Inhibition of PTP1B (unknown origin) assessed as p-nitrophenol release from pNPP substrate after 30 mins by spectrophotometry | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. |
| AID1055971 | Increase in 2-NBDG uptake in mouse 3T3L1 cells at 400 ug/ml after 30 mins by fluorescence spectrophotometry relative to DMSO-treated control | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. |
| AID1657516 | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 2 mins by Ellman's method | |||
| AID361149 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced transformation of mouse JB6 cells after 14 days by soft agar assay | 2002 | Journal of natural products, Jul, Volume: 65, Issue:7 | Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.31) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||