ketamine has been researched along with Allodynia in 151 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
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"Adding epidural or IV racemic ketamine to TEA after thoracotomy did not lead to any reduction in PPP or allodynia." | 9.19 | Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy. ( Gomar, C; Rios, J; Tena, B, 2014) |
"Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery." | 9.19 | Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014) |
" A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown." | 9.19 | Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014) |
"The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine." | 9.12 | Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007) |
" This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on human neuropathic pain states, characterized by allodynia and hyperalgesia." | 9.09 | Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. ( Leung, A; Ridgeway, B; Wallace, MS; Yaksh, T, 2001) |
"Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0." | 9.08 | NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996) |
"To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia." | 8.98 | Perioperative intravenous ketamine for acute postoperative pain in adults. ( Bell, RF; Brinck, EC; Heesen, M; Kontinen, V; Moore, RA; Straube, S; Tiippana, E, 2018) |
"This review discusses the place of the old anesthetic ketamine in pediatric anesthesia." | 8.84 | Something new about ketamine for pediatric anesthesia? ( De Kock, M; Lois, F, 2008) |
"Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain." | 8.12 | Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022) |
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics." | 7.96 | Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020) |
"In CFA-treated mice that exhibited pain behavior and depression-like behavior, ketamine reversed depression-like behavior." | 7.96 | Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice. ( Han, R; Han, S; Li, J; Peng, Y; Sun, W; Wang, J; Zhao, Q; Zhou, Y, 2020) |
"Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France." | 7.81 | Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015) |
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression." | 7.77 | A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011) |
"Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain." | 7.75 | S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009) |
"Case report of 68 year old female with central post-stroke pain successfully treated with oral ketamine." | 7.71 | Treatment of central post-stroke pain with oral ketamine. ( Lamer, TJ; Vick, PG, 2001) |
"These results demonstrated that ketamine produced antinociceptive effects through an activation of the monoaminergic descending inhibitory system, whereas, in a unilateral peripheral inflammation-induced hyperalgesic state, the monoaminergic system did not contribute to the antihyperalgesic effects of ketamine." | 7.70 | Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation. ( Kawamata, M; Kawamata, T; Namiki, A; Omote, K; Sonoda, H, 2000) |
" To reduce the risk for potential psychodysleptic side effects, however, ketamine dosing tends to be limited to low-dose regimens." | 6.82 | The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016) |
"Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain." | 6.71 | Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003) |
"The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil." | 6.68 | Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995) |
"Ketamine is an NMDA-blocking agent widely used in human medicine." | 6.67 | Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) |
"Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine." | 5.91 | A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023) |
"Depression is present in a large proportion of patients suffering from chronic pain, and yet the underlying mechanisms remain to be elucidated." | 5.48 | Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression. ( Ji, MH; Li, HH; Li, KY; Pan, W; Yang, JJ; Zhang, GF; Zhou, ZQ, 2018) |
"Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management." | 5.48 | The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain. ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018) |
"heat allodynia) followed by a persistent area of secondary tactile allodynia." | 5.36 | Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010) |
"It had less effect on tactile allodynia (CCI)." | 5.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
"Thus, transgenic mice exhibited mechanical allodynia." | 5.30 | Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists. ( Cuello, AC; Henry, JL; Julien, JP; McLeod, AL; Ribeiro-Da-Silva, A; Ritchie, J, 1999) |
"Primary outcomes were postoperative acute pain at rest/during movement after 24 h and number of patients with ketamine-related adverse events." | 5.22 | Perioperative ketamine for postoperative pain management in patients with preoperative opioid intake: A systematic review and meta-analysis. ( Kranke, P; Lipke, E; Meyer-Frießem, CH; Pogatzki-Zahn, EM; Reichl, S; Schnabel, A; Weibel, S; Zahn, PK, 2022) |
"The measurements were postoperative pain intensity during 24 hours; morphine consumption; time to first morphine supplementation; hyperalgesia (using monofilaments and an algometer) and allodynia (using a soft brush) in the thenar eminence of the nondominant hand and in the periumbilical region 24 hours after surgery; extent of hyperalgesia using a 300-g monofilament near the periumbilical region 24 hours after surgery; and serum levels of IL-6, IL-8, and IL-10." | 5.20 | Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study. ( Brunialti, MK; Leal, PC; Sakata, RK; Salomão, R, 2015) |
"Adding epidural or IV racemic ketamine to TEA after thoracotomy did not lead to any reduction in PPP or allodynia." | 5.19 | Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy. ( Gomar, C; Rios, J; Tena, B, 2014) |
"Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery." | 5.19 | Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014) |
" A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown." | 5.19 | Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014) |
"The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine." | 5.12 | Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007) |
"The results of the present study demonstrate that pre-emptive epidural ketamine is effective in reducing intra- and postoperative analgesic requirements, hyperalgesia and touch allodynia." | 5.11 | Effect of pre-emptive ketamine on sensory changes and postoperative pain after thoracotomy: comparison of epidural and intramuscular routes. ( Andersen, OK; Arendt-Nielsen, L; Camlica, H; Dereli, N; Ozyalcin, NS; Yucel, A, 2004) |
" This study tested the hypotheses that increased pain sensitivity assessed by periincisional allodynia and hyperalgesia can occur after relatively large-dose intraoperative remifentanil and that small-dose ketamine prevents this hyperalgesia." | 5.11 | Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. ( Chauvin, M; Fletcher, D; Guignard, B; Joly, V; Maurette, P; Richebe, P; Sessler, DI, 2005) |
" This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on human neuropathic pain states, characterized by allodynia and hyperalgesia." | 5.09 | Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. ( Leung, A; Ridgeway, B; Wallace, MS; Yaksh, T, 2001) |
" Alfentanil effectively inhibited electrically evoked pain and reduced pin prick hyperalgesia and allodynia during its infusion." | 5.09 | A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. ( Albrecht, S; Dern, SK; Koppert, W; Schmelz, M; Schüttler, J; Sittl, R, 2001) |
"Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0." | 5.08 | NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996) |
"In a double-blind, controlled trial, we administered doses of an opioid analgesic (alfentanil), an N-methyl-D-aspartate receptor antagonist (ketamine), or their combination to normal volunteers and found no advantage of the combination over a larger dose of either drug alone in relieving pain caused by painful chemical stimulation." | 5.08 | Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. ( Bennett, GJ; Gracely, R; Liu, M; Max, MB; Sethna, NF, 1998) |
"To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia." | 4.98 | Perioperative intravenous ketamine for acute postoperative pain in adults. ( Bell, RF; Brinck, EC; Heesen, M; Kontinen, V; Moore, RA; Straube, S; Tiippana, E, 2018) |
"This review discusses the place of the old anesthetic ketamine in pediatric anesthesia." | 4.84 | Something new about ketamine for pediatric anesthesia? ( De Kock, M; Lois, F, 2008) |
"Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain." | 4.12 | Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022) |
" His pain and agitation were difficult to manage but improved after he received ketamine." | 4.12 | Suspected opioid-induced hyperalgesia in an infant following surgery: A case report. ( Efune, PN; Rebstock, SE, 2022) |
" Osteoarthritis was induced in male adult control Wistar rats without any interventions and in Wisket rats after juvenile social isolation and ketamine treatment." | 3.96 | Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia. ( Banki, L; Büki, A; Horvath, G; Jancsó, G; Kekesi, G; Kis, G; Somogyvári, F; Tuboly, G; Varga, E; Vécsei, L, 2020) |
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics." | 3.96 | Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020) |
"In CFA-treated mice that exhibited pain behavior and depression-like behavior, ketamine reversed depression-like behavior." | 3.96 | Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice. ( Han, R; Han, S; Li, J; Peng, Y; Sun, W; Wang, J; Zhao, Q; Zhou, Y, 2020) |
"Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France." | 3.81 | Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015) |
"We report the successful use of low-dose ketamine infusion for treating a severe episode of painful myoclonus in the lower extremities, associated with opioid-induced hyperalgesia (OIH), in a patient who was receiving long-term, high dose intrathecal hydromorphone therapy." | 3.78 | Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion. ( Chan, PS; Forero, M; Restrepo-Garces, CE, 2012) |
" The effects of ketamine on SNL-induced mechanical allodynia were confirmed by behavioral testing." | 3.77 | Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain. ( Li, YQ; Mei, XP; Wang, W; Wei, YY; Xu, LX; Zhai, MZ; Zhang, H, 2011) |
"Ketamine, its active metabolite norketamine, and the NR2B-selective antagonist traxoprodil (CP-101,606) were tested in rat models of acute antinociception (paw-withdrawal response to heat) and chronic neuropathic pain (spared nerve injury)." | 3.77 | Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain. ( Aarts, L; Dahan, A; Morariu, A; Niesters, M; Swartjes, M, 2011) |
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression." | 3.77 | A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011) |
"Intrathecal ketamine (10, 100, 1000 μg/kg) or LAA (10, 50, 100 nmol) alleviated SNL-induced mechanical allodynia in a dose-dependent manner respectively." | 3.76 | Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain. ( Chen, L; Li, YQ; Mei, XP; Wang, W; Wu, SX; Xu, LX; Zhang, T; Zhu, C, 2010) |
"Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain." | 3.75 | S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009) |
"04 mg/kg, subcutaneous) significantly enhanced mechanical allodynia and thermal hyperalgesia induced by the plantar incision during the postoperative period (each lasting between 2 h and 48 h), which was attenuated by pretreatment with ketamine (10 mg/kg, subcutaneous)." | 3.75 | Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine. ( Cui, S; Gu, X; Liu, Y; Ma, Z; Wu, X, 2009) |
"Case report of 68 year old female with central post-stroke pain successfully treated with oral ketamine." | 3.71 | Treatment of central post-stroke pain with oral ketamine. ( Lamer, TJ; Vick, PG, 2001) |
"These results demonstrated that ketamine produced antinociceptive effects through an activation of the monoaminergic descending inhibitory system, whereas, in a unilateral peripheral inflammation-induced hyperalgesic state, the monoaminergic system did not contribute to the antihyperalgesic effects of ketamine." | 3.70 | Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation. ( Kawamata, M; Kawamata, T; Namiki, A; Omote, K; Sonoda, H, 2000) |
"Ketamine is known to modulate hyperalgesia induced by central sensitization." | 2.87 | Preventative effect of ketamine on post-surgical hyperalgesia induced at a body part remote from the surgical site. ( Jeon, YJ; Kim, MH; Lee, HM; Moon, YE; Yoon, HM, 2018) |
"Ketamine (Ket) was developed in 1962 as a less hallucinogenic and shorter acting agent than phencyclidine." | 2.82 | Ketamine; history and role in anesthetic pharmacology. ( Hirota, K; Lambert, DG, 2022) |
" To reduce the risk for potential psychodysleptic side effects, however, ketamine dosing tends to be limited to low-dose regimens." | 2.82 | The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016) |
"ketamine was ineffective." | 2.73 | Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system. ( Hopf, HC; Klein, T; Magerl, W; Nickel, U; Sandkühler, J; Treede, RD, 2007) |
" The first analysis included 19 comparisons on a single ketamine dose and measurement of effect within 3 hours of dosing and showed an appreciable effect (standardized mean difference 1." | 2.72 | Efficacy of ketamine in relieving neuropathic pain: a systematic review and meta-analysis of animal studies. ( Dahan, A; Dahan, JDC; Hooijmans, CR; Mogil, JS; van Dorp, ELA; Velzen, MV, 2021) |
"Both the intensity and unpleasantness of mechanical hyperalgesia was statistically significantly reduced by ketamine gel applied both on the left and right side." | 2.72 | Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia. ( Pöyhiä, R; Vainio, A, 2006) |
"Parecoxib (40 mg) was administered intravenously either with onset of electrical stimulation (preventive) or in parallel to the remifentanil infusion." | 2.72 | Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. ( Koppert, W; Schmelz, M; Schüttler, J; Singler, B; Sittl, R; Tröster, A, 2006) |
"Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain." | 2.71 | Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003) |
"The ketamine infusion was started after baseline testing at a constant target concentration." | 2.71 | Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans. ( Arendt-Nielsen, L; Curatolo, M; Gerber, A; Luginbühl, M; Petersen-Felix, S; Schnider, TW, 2003) |
"The magnitude of pain and area of hyperalgesia were assessed before, during, and after drug infusion (remifentanil at 0." | 2.71 | Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. ( Alsheimer, M; Koppert, W; Scheuber, K; Schmelz, M; Schüttler, J; Sittl, R, 2003) |
"Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids." | 2.71 | Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. ( Angst, MS; Clark, DJ; Koppert, W; Pahl, I; Schmelz, M, 2003) |
"Although postoperative pain measurements did not differ, postoperative epidural treatment (intravenous-epidural) was less effective to prevent residual pain at 1 yr (11%; P = 0." | 2.71 | Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. ( De Kock, M; Lavand'homme, P; Waterloos, H, 2005) |
"Wound mechanical hyperalgesia was evaluated and residual pain was assessed by asking the patients at 2 weeks, and 1, 6, and 12 months." | 2.70 | 'Balanced analgesia' in the perioperative period: is there a place for ketamine? ( De Kock, M; Lavand'homme, P; Waterloos, H, 2001) |
"Ketamine is an NMDA-receptor antagonist and has proven effective in alleviating secondary hyperalgesia in humans." | 2.69 | The effect of naloxone on ketamine-induced effects on hyperalgesia and ketamine-induced side effects in humans. ( Borgbjerg, FM; Brennum, J; Dahl, JB; Ilkjaer, S; Mikkelsen, S, 1999) |
"Ketamine failed to inhibit both secondary hyperalgesia and axon reflex flare as long as nonlocal anesthetic concentrations were applied." | 2.69 | The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction. ( Blunk, JA; Koppert, W; Likar, R; Schmelz, M; Sittl, R; Zeck, S, 1999) |
"The area of secondary hyperalgesia was quantitated using punctate (von Frey filaments) and brush stimuli (electric brush)." | 2.69 | Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man. ( Jørum, E; Stubhaug, A; Warncke, T, 2000) |
"Pain scores and areas of hyperalgesia were not affected when the contralateral site was infiltrated with ketamine or lidocaine." | 2.69 | Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans. ( Arendt-Nielsen, L; Bach, FW; Gottrup, H; Jensen, TS, 2000) |
"The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil." | 2.68 | Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995) |
"Ketamine caused an increase in the summation threshold compared to the placebo treatment." | 2.68 | The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study. ( Andersen, OK; Arendt-Nielsen, L; Bjerring, P; Felsby, S; Jensen, TS; Nicolaisen, L, 1996) |
"Primary hyperalgesia was determined by measuring heat pain detection threshold (HPDT) within the site of injury." | 2.68 | Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 1997) |
"Using punctuate mechanical hyperalgesia as a measure of central sensitization, we examined whether induction and maintenance of central sensitization after surgery could be prevented by a low-dose infusion of the NMDA-receptor antagonist ketamine." | 2.68 | Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. ( Breivik, H; Eide, PK; Foss, A; Kreunen, M; Stubhaug, A, 1997) |
"Ketamine is an NMDA-blocking agent widely used in human medicine." | 2.67 | Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) |
"The surgical wound hyperalgesia was assessed by measuring pain threshold to pressure on the wound by using an algometer, and also by measuring the intensity of pain to suprathreshold pressure on the wound with the visual analog self-rating method." | 2.67 | Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. ( Bradley, EL; Finger, J; Isakson, A; Kissin, I; Oz, Y; Tverskoy, M, 1994) |
"Three types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia." | 2.48 | [Prevention of postoperative hyperalgesia]. ( Mamie, C, 2012) |
"Recent advances in the understanding of postoperative pain have demonstrated its association with sensitization of the central nervous system (CNS) which clinically elicits pain hypersensitivity." | 2.44 | The clinical role of NMDA receptor antagonists for the treatment of postoperative pain. ( De Kock, MF; Lavand'homme, PM, 2007) |
"The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
"Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine." | 1.91 | A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023) |
"Ketamine was injected intraperitoneally daily for 4 weeks, discontinued for 2 weeks, and then readministered for 1 week." | 1.72 | Response After Repeated Ketamine Injections in a Rat Model of Neuropathic Pain. ( Choi, JB; Chung, HT; Kim, BG; Kim, NA; Kim, YS; Kwon, HR; Lee, J; Song, JH, 2022) |
"capsaicin-induced thermal allodynia) are unknown." | 1.48 | Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys. ( Banks, ML; Cornelissen, JC; Nicholson, KL; Rice, KC; Steele, FF, 2018) |
"Depression is present in a large proportion of patients suffering from chronic pain, and yet the underlying mechanisms remain to be elucidated." | 1.48 | Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression. ( Ji, MH; Li, HH; Li, KY; Pan, W; Yang, JJ; Zhang, GF; Zhou, ZQ, 2018) |
"Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management." | 1.48 | The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain. ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018) |
"Allodynia/hyperalgesia area did not differ between groups and was infrequent and slight." | 1.46 | Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine. ( Coca, M; Gomar, C; Masgoret, P; Ríos, J; Taurá, P; Tena, B, 2017) |
"We studied sensitivity of mechanical hyperalgesia induced by a single intrathecal (i." | 1.46 | Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study. ( Constandil, L; Galleguillos, D; Hernández, A; Marcos, JL; Pelissier, T; Velásquez, L; Villanueva, L, 2017) |
"Ketamine had less mechanical hyperalgesia in 6 h (p = 0." | 1.43 | A comparison of intrathecal magnesium and ketamine in attenuating remifentanil-induced hyperalgesia in rats. ( Ansong, E; Dong, J; Feng, X; Lin, H; Sun, J; Xu, X, 2016) |
"Opioid-induced hyperalgesia was associated with an increase in the MAC in normal rats who had not undergone surgery." | 1.42 | Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Segura, IA, 2015) |
"In morphine-only infusion rats, hyperalgesia and opioid insensitivity were both increased." | 1.42 | Long-Term Antihyperalgesic and Opioid-Sparing Effects of 5-Day Ketamine and Morphine Infusion ("Burst Ketamine") in Diabetic Neuropathic Rats. ( Broadbear, JH; Goodchild, CS; Kolosov, A; Mak, P, 2015) |
"Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P < 0." | 1.42 | Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. ( Cheung, CW; Choi, SW; Irwin, M; Liman, S; Ng, KF; Qiu, Q; Tai, W; Wong, KL, 2015) |
"Tramadol-induced hyperalgesia in the rat lasted for several weeks and was associated with an increase in the MAC of sevoflurane." | 1.42 | Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Gómez de Segura, IA, 2015) |
"Ketamine was then tested as a potential therapeutic drug." | 1.39 | Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine. ( Beaudry, F; Castel, A; Hélie, P; Vachon, P, 2013) |
"co-treatment with ketamine and pregabalin at sub-effect low doses may be a useful therapeutic method for the treatment of neuropathic pain patients." | 1.39 | Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice. ( Choi, JG; Jeon, BH; Kim, HW; Kim, JM; Ko, YK; Lee, JH; Lim, HS; Park, JB; Shin, YS, 2013) |
"The patient also developed hyperalgesia, allodynia, and photophobia and became extremely irritable upon handling." | 1.38 | Suspected opioid-induced hyperalgesia in an infant. ( Chalkiadis, GA; Hallett, BR, 2012) |
"Buprenorphine has a better analgesia/toxicity profile (a ceiling effect for respiratory depression, less potential for abuse) compared to typical mu-opioids." | 1.37 | Buprenorphine-induced hyperalgesia in the rat. ( Holtman, JR; Wala, EP, 2011) |
"Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
"Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg." | 1.37 | The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011) |
"In prestressed rats, fULD-induced hyperalgesia and the exaggerated inflammatory hyperalgesia were prevented NMDA receptor antagonists." | 1.37 | Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process. ( Chateauraynaud, J; Gavello-Baudy, S; Laboureyras, E; Laulin, JP; Le Roy, C; Simonnet, G, 2011) |
"Ketamine is an important analgesia clinically used for both acute and chronic pain." | 1.37 | Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain. ( Hayashi, Y; Inoue, K; Kawaji, K; Kohsaka, S; Koyano, K; Nakanishi, H; Sun, L; Yokoyama, T; Zhang, X, 2011) |
"Morphine was more effective in ketamine-treated (1 and 50 mg kg(-1)) mice." | 1.36 | Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine. ( Fourcade, O; Girolami, JP; Minville, V; Tack, I, 2010) |
"heat allodynia) followed by a persistent area of secondary tactile allodynia." | 1.36 | Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010) |
"Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor." | 1.36 | The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. ( Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS, 2010) |
"It had less effect on tactile allodynia (CCI)." | 1.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
"The induction of chest wall somatic allodynia was accompanied by a reduction in the latency of the P1 (36 +/- 3 ms to 30 +/- 4 ms p = 0." | 1.34 | Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification - evidence of central sensitization. ( Aziz, Q; Delaney, C; Hobson, AR; Kelly, K; Sharma, A; Willert, RP, 2007) |
"In children with advanced stages of cancer, pain control remains inadequate in many patients and a solution to this problem is sorely lacking." | 1.34 | Ketamine as an adjuvant for treatment of cancer pain in children and adolescents. ( Finkel, JC; Pestieau, SR; Quezado, ZM, 2007) |
"Inflammation was induced with a unilateral subcutaneous injection of Car in a plantar hindpaw in rats fed without (control group) or with (deficiency group) a polyamine-deficient diet." | 1.33 | An evaluation of a polyamine-deficient diet for the treatment of inflammatory pain. ( Ecoffey, C; Estebe, JP; Gentili, M; Leduc, C; Legay, F; Moulinoux, JP; Wodey, E, 2006) |
"Opioid-induced hyperalgesia has been demonstrated in awake animals." | 1.32 | Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia. ( Boulanger, V; Collet, V; De Kock, M; Docquier, MA; Lavand'homme, P, 2004) |
"The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
"Ketamine pretreatment, which had no analgesic effect on its own, enhanced the earlier response (analgesia) and prevented the development of long-lasting hyperalgesia." | 1.31 | Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. ( Célèrier, E; Jun, Y; Larcher, A; Laulin, JP; Reynier, P; Rivat, C; Simonnet, G, 2000) |
"ketamine was effective only when given as a pretreatment." | 1.31 | Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model. ( Lee, IH; Lee, IO, 2001) |
"Ketamine pretreatment (10 mg/kg) increased the fentanyl analgesic effect (4 x 60 microg/kg), suppressed the immediate hyperalgesic phase, and restored the full effect of a subsequent morphine injection." | 1.31 | The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. ( Chauvin, M; Corcuff, JB; Laulin, JP; Maurette, P; Rivat, C; Simonnet, G, 2002) |
" The results demonstrate that the behavioral hyperalgesia associated with carrageenan-induced hindpaw inflammation in rats is attenuated by the intrathecal administration of racemic and S(+)-ketamine, but not R(-)-ketamine, which only displayed an insignificant trend toward a dose-response relationship." | 1.30 | Antinociceptive effect of the S(+)-enantiomer of ketamine on carrageenan hyperalgesia after intrathecal administration in rats. ( Benedek, G; Dobos, I; Horváth, G; Klimscha, W; Szikszay, M, 1998) |
"The onset of resultant hyperalgesia was evaluated using von Frey monofilaments." | 1.30 | Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat. ( Hartrick, CT; Patterson, JS; Wise, JJ, 1998) |
"The CCI rats showed hyperalgesia to thermal and mechanical pressure stimuli on the injured side of their hind paws." | 1.30 | [Suppressive effects of ketamine on neuropathic pain]. ( Omote, K; Sonoda, H, 1998) |
"Thus, transgenic mice exhibited mechanical allodynia." | 1.30 | Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists. ( Cuello, AC; Henry, JL; Julien, JP; McLeod, AL; Ribeiro-Da-Silva, A; Ritchie, J, 1999) |
"Moreover, the absence of mechanical hyperalgesia raises the possibility that central changes in noxious information processing may not be detected using mechanical stimuli in the same time course as thermal stimuli." | 1.29 | The effect of abdominal surgery on thresholds to thermal and mechanical stimulation in sheep. ( Nolan, AM; Welsh, EM, 1995) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 24 (15.89) | 18.2507 |
2000's | 58 (38.41) | 29.6817 |
2010's | 56 (37.09) | 24.3611 |
2020's | 13 (8.61) | 2.80 |
Authors | Studies |
---|---|
Meyer-Frießem, CH | 1 |
Lipke, E | 1 |
Weibel, S | 1 |
Kranke, P | 1 |
Reichl, S | 1 |
Pogatzki-Zahn, EM | 1 |
Zahn, PK | 1 |
Schnabel, A | 1 |
Hino, C | 1 |
Ran-Castillo, D | 1 |
Akhtari, M | 1 |
Cao, H | 1 |
Silvestre, J | 1 |
Kim, NA | 1 |
Kim, BG | 1 |
Lee, J | 1 |
Chung, HT | 1 |
Kwon, HR | 1 |
Kim, YS | 1 |
Choi, JB | 1 |
Song, JH | 1 |
Hirota, K | 1 |
Lambert, DG | 1 |
Efune, PN | 1 |
Rebstock, SE | 1 |
McDonald, WM | 1 |
Wilkinson, MM | 1 |
Jain, A | 1 |
Cohen, SP | 1 |
Zhou, X | 1 |
Li, Q | 1 |
Luo, Q | 1 |
Wang, L | 2 |
Chen, J | 1 |
Xiong, Y | 1 |
Wu, G | 1 |
Chang, L | 1 |
Liu, P | 1 |
Shu, H | 1 |
Qi, F | 1 |
Liu, T | 1 |
Zhang, X | 2 |
Gao, X | 1 |
Li, Z | 1 |
Chen, L | 2 |
Lin, C | 1 |
Wang, ZJ | 1 |
Tang, H | 1 |
Chen, Z | 1 |
Banki, L | 1 |
Büki, A | 1 |
Horvath, G | 3 |
Kekesi, G | 1 |
Kis, G | 1 |
Somogyvári, F | 1 |
Jancsó, G | 1 |
Vécsei, L | 1 |
Varga, E | 1 |
Tuboly, G | 2 |
Coutens, B | 1 |
Derreumaux, C | 1 |
Labaste, F | 1 |
Minville, V | 2 |
Guiard, BP | 1 |
Moulédous, L | 1 |
Bounes, V | 1 |
Roussin, A | 1 |
Frances, B | 1 |
Viisanen, H | 1 |
Lilius, TO | 1 |
Sagalajev, B | 1 |
Rauhala, P | 1 |
Kalso, E | 1 |
Pertovaara, A | 1 |
Velzen, MV | 1 |
Dahan, JDC | 1 |
van Dorp, ELA | 1 |
Mogil, JS | 1 |
Hooijmans, CR | 1 |
Dahan, A | 4 |
Kopsky, DJ | 1 |
Keppel Hesselink, JM | 1 |
Masgoret, P | 1 |
Gomar, C | 2 |
Tena, B | 2 |
Taurá, P | 1 |
Ríos, J | 2 |
Coca, M | 1 |
Marcos, JL | 1 |
Galleguillos, D | 1 |
Pelissier, T | 2 |
Hernández, A | 2 |
Velásquez, L | 1 |
Villanueva, L | 1 |
Constandil, L | 1 |
Moon, YE | 1 |
Kim, MH | 1 |
Lee, HM | 1 |
Yoon, HM | 1 |
Jeon, YJ | 1 |
Cornelissen, JC | 1 |
Steele, FF | 1 |
Rice, KC | 1 |
Nicholson, KL | 1 |
Banks, ML | 1 |
Porter, SB | 1 |
Schwenk, ES | 1 |
Pan, W | 2 |
Zhang, GF | 2 |
Li, HH | 1 |
Ji, MH | 1 |
Zhou, ZQ | 1 |
Li, KY | 1 |
Yang, JJ | 2 |
Breivik, H | 2 |
Brinck, EC | 1 |
Tiippana, E | 1 |
Heesen, M | 1 |
Bell, RF | 1 |
Straube, S | 1 |
Moore, RA | 1 |
Kontinen, V | 1 |
Hayhurst, CJ | 1 |
Farrin, E | 1 |
Hughes, CG | 1 |
Barelli, R | 1 |
Morelli Sbarra, G | 1 |
Sbaraglia, F | 1 |
Zappia, L | 1 |
Rossi, M | 1 |
Thompson, T | 1 |
Whiter, F | 1 |
Gallop, K | 1 |
Veronese, N | 1 |
Solmi, M | 1 |
Newton, P | 1 |
Stubbs, B | 1 |
Wang, J | 4 |
Zhao, Q | 1 |
Zhou, Y | 2 |
Sun, W | 1 |
Han, S | 1 |
Peng, Y | 1 |
Li, J | 1 |
Han, R | 1 |
Willeford, A | 1 |
Atayee, RS | 1 |
Winters, KD | 1 |
Mesarwi, P | 1 |
Castel, A | 1 |
Hélie, P | 1 |
Beaudry, F | 1 |
Vachon, P | 1 |
Ohnesorge, H | 1 |
Feng, Z | 1 |
Zitta, K | 1 |
Steinfath, M | 1 |
Albrecht, M | 1 |
Bein, B | 1 |
Jabbour, HJ | 1 |
Naccache, NM | 1 |
Jawish, RJ | 1 |
Abou Zeid, HA | 1 |
Jabbour, KB | 1 |
Rabbaa-Khabbaz, LG | 1 |
Ghanem, IB | 1 |
Yazbeck, PH | 1 |
Pestieau, SR | 2 |
Finkel, JC | 2 |
Junqueira, MM | 1 |
Cheng, Y | 1 |
Lovejoy, JF | 1 |
Quezado, Z | 1 |
M'Dahoma, S | 1 |
Bourgoin, S | 1 |
Kayser, V | 1 |
Barthélémy, S | 1 |
Chevarin, C | 1 |
Chali, F | 1 |
Orsal, D | 1 |
Hamon, M | 1 |
Birklein, F | 1 |
O'Neill, D | 1 |
Schlereth, T | 1 |
Abreu, M | 2 |
Aguado, D | 2 |
Benito, J | 2 |
García-Fernández, J | 2 |
Segura, IA | 1 |
Juel, J | 1 |
Olesen, SS | 1 |
Olesen, AE | 1 |
Poulsen, JL | 1 |
Wilder-Smith, O | 1 |
Madzak, A | 1 |
Frøkjær, JB | 1 |
Drewes, AM | 1 |
Mak, P | 1 |
Broadbear, JH | 1 |
Kolosov, A | 1 |
Goodchild, CS | 1 |
Zhang, C | 1 |
Li, SS | 1 |
Zhao, N | 1 |
Yu, C | 2 |
Leal, PC | 1 |
Salomão, R | 1 |
Brunialti, MK | 1 |
Sakata, RK | 1 |
Liman, S | 1 |
Cheung, CW | 1 |
Wong, KL | 1 |
Tai, W | 1 |
Qiu, Q | 1 |
Ng, KF | 1 |
Choi, SW | 1 |
Irwin, M | 1 |
Nickel, FT | 1 |
Ott, S | 1 |
Möhringer, S | 1 |
Münster, T | 1 |
Rieß, S | 1 |
Filitz, J | 1 |
Koppert, W | 6 |
Maihöfner, C | 1 |
Gómez de Segura, IA | 1 |
Martinez, V | 1 |
Derivaux, B | 1 |
Beloeil, H | 1 |
Bornemann-Cimenti, H | 1 |
Wejbora, M | 1 |
Michaeli, K | 1 |
Edler, A | 1 |
Sandner-Kiesling, A | 1 |
Han, JF | 1 |
Guo, J | 1 |
Xie, ZM | 1 |
Sun, KJ | 1 |
Sun, J | 1 |
Lin, H | 1 |
Feng, X | 1 |
Dong, J | 1 |
Ansong, E | 1 |
Xu, X | 1 |
Holtman, JR | 3 |
Crooks, PA | 1 |
Johnson-Hardy, JK | 1 |
Hojomat, M | 1 |
Kleven, M | 1 |
Wala, EP | 3 |
Benedek, G | 2 |
Mion, G | 1 |
Libert, N | 1 |
Cirodde, A | 1 |
Tourtier, JP | 1 |
Rousseau, JM | 1 |
Ben-David, B | 1 |
Chelly, JE | 1 |
Garrido-Suárez, BB | 1 |
Garrido, G | 1 |
Márquez, L | 1 |
Martínez, I | 1 |
Hernández, I | 1 |
Merino, N | 1 |
Luque, Y | 1 |
Delgado, R | 1 |
Bosch, F | 1 |
Kitamura, T | 1 |
Imai, Y | 1 |
Ohno, N | 1 |
Muroya, M | 1 |
Ogawa, M | 1 |
Yamada, Y | 1 |
Sigtermans, M | 1 |
Mooren, R | 1 |
Bauer, M | 1 |
Kest, B | 1 |
Sarton, E | 1 |
Olofsen, E | 1 |
Boettger, MK | 1 |
Weber, K | 1 |
Gajda, M | 1 |
Bräuer, R | 1 |
Schaible, HG | 1 |
Fourcade, O | 1 |
Girolami, JP | 1 |
Tack, I | 1 |
Gu, X | 1 |
Wu, X | 1 |
Liu, Y | 1 |
Cui, S | 1 |
Ma, Z | 1 |
Marchant, N | 1 |
Joris, J | 1 |
Modir, JG | 1 |
Wallace, MS | 3 |
Griffiths, R | 1 |
Mei, XP | 3 |
Wang, W | 6 |
Zhu, C | 1 |
Zhang, T | 1 |
Xu, LX | 3 |
Wu, SX | 1 |
Li, YQ | 3 |
Rondon, ES | 1 |
Vieira, AS | 1 |
Valadão, CA | 1 |
Parada, CA | 1 |
Zhang, H | 2 |
Wei, YY | 1 |
Zhai, MZ | 1 |
Tang, J | 1 |
Hang, LH | 1 |
Shao, DH | 1 |
Gu, YP | 1 |
Swartjes, M | 1 |
Morariu, A | 1 |
Niesters, M | 1 |
Aarts, L | 1 |
Quintero, L | 1 |
Cardenas, R | 1 |
Suarez-Roca, H | 1 |
Van Elstraete, AC | 2 |
Sitbon, P | 2 |
Benhamou, D | 2 |
Mazoit, JX | 2 |
Forero, M | 1 |
Chan, PS | 1 |
Restrepo-Garces, CE | 1 |
Le Roy, C | 1 |
Laboureyras, E | 1 |
Gavello-Baudy, S | 1 |
Chateauraynaud, J | 1 |
Laulin, JP | 3 |
Simonnet, G | 3 |
Romero, TR | 1 |
Galdino, GS | 1 |
Silva, GC | 1 |
Resende, LC | 1 |
Perez, AC | 1 |
Côrtes, SF | 1 |
Duarte, ID | 1 |
Goffer, Y | 1 |
Xu, D | 1 |
Tukey, DS | 1 |
Shamir, DB | 1 |
Eberle, SE | 1 |
Zou, AH | 1 |
Blanck, TJ | 1 |
Ziff, EB | 1 |
Hallett, BR | 1 |
Chalkiadis, GA | 1 |
Hayashi, Y | 1 |
Kawaji, K | 1 |
Sun, L | 1 |
Koyano, K | 1 |
Yokoyama, T | 1 |
Kohsaka, S | 1 |
Inoue, K | 1 |
Nakanishi, H | 1 |
Mamie, C | 1 |
Yalcin, N | 1 |
Uzun, ST | 1 |
Reisli, R | 1 |
Borazan, H | 1 |
Otelcioglu, S | 1 |
Slater, H | 1 |
Graven-Nielsen, T | 2 |
Wright, A | 1 |
Schug, SA | 1 |
Lim, HS | 1 |
Kim, JM | 1 |
Choi, JG | 1 |
Ko, YK | 1 |
Shin, YS | 1 |
Jeon, BH | 1 |
Park, JB | 1 |
Lee, JH | 1 |
Kim, HW | 1 |
Colpaert, FC | 1 |
Tarayre, JP | 1 |
Koek, W | 1 |
Pauwels, PJ | 1 |
Bardin, L | 1 |
Xu, XJ | 1 |
Wiesenfeld-Hallin, Z | 1 |
Cosi, C | 1 |
Carilla-Durand, E | 1 |
Assié, MB | 1 |
Vacher, B | 1 |
Jørum, E | 4 |
Warncke, T | 4 |
Stubhaug, A | 6 |
Luginbühl, M | 1 |
Gerber, A | 1 |
Schnider, TW | 1 |
Petersen-Felix, S | 1 |
Arendt-Nielsen, L | 7 |
Curatolo, M | 1 |
Oatway, M | 1 |
Reid, A | 1 |
Sawynok, J | 1 |
Sittl, R | 4 |
Scheuber, K | 1 |
Alsheimer, M | 1 |
Schmelz, M | 5 |
Schüttler, J | 3 |
Alvarez, P | 1 |
Angst, MS | 1 |
Pahl, I | 1 |
Clark, DJ | 1 |
Willert, RP | 2 |
Woolf, CJ | 1 |
Hobson, AR | 2 |
Delaney, C | 2 |
Thompson, DG | 1 |
Aziz, Q | 2 |
Gottrup, H | 3 |
Bach, FW | 2 |
Jensen, TS | 6 |
Raeder, J | 1 |
Chaaben, K | 1 |
Marret, E | 1 |
Lamonerie, L | 1 |
Lembert, N | 1 |
Bonnet, F | 1 |
Docquier, MA | 1 |
Lavand'homme, P | 3 |
Boulanger, V | 1 |
Collet, V | 1 |
De Kock, M | 4 |
Ozyalcin, NS | 1 |
Yucel, A | 1 |
Camlica, H | 1 |
Dereli, N | 1 |
Andersen, OK | 2 |
Joly, V | 1 |
Richebe, P | 1 |
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Fletcher, D | 1 |
Maurette, P | 2 |
Sessler, DI | 1 |
Chauvin, M | 2 |
Brennan, TJ | 1 |
Kehlet, H | 1 |
Waterloos, H | 2 |
Luo, YL | 1 |
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Li, Y | 1 |
Zhang, Q | 1 |
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Pöyhiä, R | 1 |
Vainio, A | 1 |
Petrenko, AB | 1 |
Yamakura, T | 1 |
Askalany, AR | 1 |
Kohno, T | 1 |
Sakimura, K | 1 |
Baba, H | 1 |
Estebe, JP | 1 |
Legay, F | 1 |
Gentili, M | 1 |
Wodey, E | 1 |
Leduc, C | 1 |
Ecoffey, C | 1 |
Moulinoux, JP | 1 |
Guntz, E | 1 |
Talla, G | 1 |
Roman, A | 1 |
Dumont, H | 1 |
Segers, B | 1 |
Sosnowski, M | 1 |
Tröster, A | 1 |
Singler, B | 1 |
Klein, T | 1 |
Magerl, W | 1 |
Nickel, U | 1 |
Hopf, HC | 1 |
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de Laforte, C | 1 |
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Haugan, F | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
(2R,6R)-Hydroxynorketamine a Novel Therapeutic Analgesic for the Treatment of Neuropathic Pain: A Randomized Double Blind Cross-Over Trial.[NCT05864053] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
The Effect of Low-dose of S-ketamine Combined With Sufentanil for Postoperative Patient-controlled Intravenous Analgesia in Patients Following Cesarean Section[NCT05299866] | Phase 4 | 216 participants (Anticipated) | Interventional | 2022-04-12 | Recruiting | ||
Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial[NCT04964219] | Phase 4 | 164 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial[NCT04791059] | Phase 4 | 200 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
Observational Study of the Efficacy of Ketamine for Rescue Analgesia in the Post Anesthesia Recovery Room[NCT04701008] | 143 participants (Actual) | Observational | 2020-09-01 | Completed | |||
The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283] | Phase 4 | 1,544 participants (Anticipated) | Interventional | 2021-04-12 | Enrolling by invitation | ||
Is The Pre-Emptive Administration Of Ketamine A Significant Adjunction To Intravenous Morphine Analgesia For Controlling Post-Operative Pain? A Randomized, Double Blind, Placebo Controlled Clinical Trial.[NCT03415191] | 75 participants (Actual) | Interventional | 2012-01-05 | Completed | |||
The Comparison of Analgesia Methods Used for Spinal Surgery[NCT04603638] | 82 participants (Anticipated) | Interventional | 2020-03-04 | Recruiting | |||
The Effect of a Regimen of Opioid Sparing Anesthesia on Postoperative Recovery[NCT05594407] | 60 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | |||
Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents[NCT01325493] | Phase 4 | 54 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
Pilot Study on the Assessment of Motor Imaging Skills in Patients With Complex Regional Pain Syndrome (CRPS)[NCT04703348] | 129 participants (Actual) | Interventional | 2021-01-12 | Completed | |||
Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals[NCT05473338] | 250 participants (Anticipated) | Observational | 2022-04-14 | Active, not recruiting | |||
A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation[NCT06096181] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024] | Phase 4 | 174 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial[NCT05950646] | Phase 4 | 154 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
Dexmedetomidine-esketamine Combined With Oxycodone for Ultrasound-guided Percutaneous Radiofrequency Ablation in Patients With Liver Cancer: a Randomized Controlled Study[NCT06003218] | 88 participants (Anticipated) | Interventional | 2023-10-16 | Recruiting | |||
Efficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind Trial[NCT06062550] | Phase 4 | 312 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial[NCT06087510] | Phase 4 | 312 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial[NCT05732064] | Phase 4 | 180 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
A Randomized Controlled Trial to Determine the Efficacy of Ketamine as an Adjunct for Pain Management in Patients With Sickle Cell Crisis[NCT03502421] | Phase 3 | 0 participants (Actual) | Interventional | 2018-09-01 | Withdrawn (stopped due to Never IRB approved, no intention to proceed with the study) | ||
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia[NCT03066739] | Phase 2 | 105 participants (Anticipated) | Interventional | 2023-02-25 | Recruiting | ||
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease, a Pilot Study[NCT02801292] | Phase 3 | 20 participants (Anticipated) | Interventional | 2016-07-31 | Not yet recruiting | ||
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia Using Filaments, an Algometer, and Interleukins: a Double-blind, Randomized Study[NCT01301079] | Phase 3 | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
Can Opioid-induced Hyperalgesia be Prevented by Gradual Dose Reduction vs. Abrupt Withdrawal of Remifentanil?[NCT01702389] | Phase 4 | 16 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis[NCT02571491] | Phase 2 | 48 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
Influence of Intraoperative Analgesia (Sufentanil Administered According to the Usual Criteria or Remifentanil Administered by a Closed-loop System Using Bispectral Index as the Controller) on the Postoperative Morphine Consumption[NCT00772616] | Phase 4 | 60 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial[NCT02421913] | Phase 4 | 42 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery[NCT02416752] | 222 participants (Actual) | Observational | 2011-08-31 | Completed | |||
Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
Transversus Abdominis Plane (TAP) Block for Cesarean Section[NCT01015807] | 90 participants (Actual) | Interventional | 2009-11-30 | Completed | |||
Pre-Emptive Analgesia in Ano-Rectal Surgery[NCT02402543] | 90 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904] | 15 participants (Anticipated) | Observational | 2011-06-30 | Recruiting | |||
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091] | Phase 2 | 10 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)[NCT02422290] | Phase 1/Phase 2 | 5 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
Phase 4 Study of Prevention of Persistent Postsurgical Pain After Thoracotomy Using Ketamine[NCT01243801] | Phase 4 | 104 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726] | 150 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | |||
Ketamine Tolerance in Children After Repeated Administrations During Radiotherapy Sessions[NCT02512055] | Phase 4 | 33 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
Effects of Perioperative Systemic Ketamine on Development of Long-term Neuropathic Pain After Thoracotomy.[NCT00313378] | Phase 3 | 78 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients.[NCT00163969] | Phase 4 | 40 participants | Interventional | 2002-04-30 | Completed | ||
Nitrous Oxide as Treatment for Fibromyalgia[NCT05357066] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-11-12 | Recruiting | ||
Efficacy of Memantine in the Treatment of Fibromyalgia: a Double-blind Randomized Trial[NCT01653457] | Phase 3 | 60 participants (Anticipated) | Interventional | 2012-09-30 | Not yet recruiting | ||
The Effects of Subanesthetic Ketamine on Respiratory Stimulation and Transpulmonary Pressures in Mechanically Ventilated Critically Ill Patients[NCT01969227] | 15 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
Effects of Low Doses of Ketamine on Postoperative Quality of Recovery After Total Intravenous Anesthesia[NCT02571153] | Phase 4 | 135 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department[NCT02489630] | Phase 4 | 116 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia[NCT00373893] | Phase 1 | 12 participants | Interventional | 2005-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Morphine consumption (mg/kg) was measured over time in the Ketamine group and compared to the Control (saline) group. Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: at 24, 48, 72, 96 hours post operatively
Intervention | mg/kg (Mean) | |||
---|---|---|---|---|
24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
Ketamine | 1.3 | 1.28 | .89 | .57 |
Saline | 1.36 | 1.275 | .93 | .38 |
Patient volunteered response at rest, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
Intervention | pain score at rest (Mean) | |||
---|---|---|---|---|
24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
Ketamine | 3.9 | 4.53 | 3.6 | 4.48 |
Saline | 4.55 | 5.2 | 3.48 | 3.8 |
Patient volunteered response during a cough, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
Intervention | pain score at cough (Mean) | |||
---|---|---|---|---|
24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
Ketamine | 4.5 | 5.4 | 4.4 | 5.15 |
Saline | 5.1 | 5.45 | 3.7 | 4.2 |
"Sedation scores 0 = completely awake~= sleepy but responds appropriately~= somnolent but arouses to light stimuli~= asleep but responsive to deeper physical stimuli~= asleep and not responsive to any stimuli Values are for each 24 hour time period and displayed as hours post surgery." (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
Intervention | Sedation Score (Mean) | |||
---|---|---|---|---|
24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
Ketamine | .73 | .62 | .38 | .24 |
Saline | .75 | .54 | .3 | .21 |
The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure
Intervention | participants (Number) |
---|---|
Ketamine | 1 |
Saline | 0 |
The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)
Intervention | participants (Number) |
---|---|
Ketamine | 1 |
Saline | 0 |
The evaluations using the soft brush were performed in the thenar eminence of the non dominant hand 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure
Intervention | participants (Number) |
---|---|
Ketamine | 1 |
Saline | 3 |
The evaluations using the soft brush were performed in the thenar eminence of the nondominant hand before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)
Intervention | participants (Number) |
---|---|
Ketamine | 1 |
Saline | 0 |
The 300-g filament was used 24 hours after the operation to induce a stimulus and delineate the extent of hyperalgesia from the periumbilical region. The stimulus was started outside the periumbilical region, where no pain sensation was reported, and continued every 0.5 cm until the 4 points of the periumbilical scar were reached (top, right side, left side, and bottom). The first point where the patient complained of pain was marked. If no pain sensation was reported, the stimulus was terminated 0.5 cm from the incision. The distance of each point from the surgical incision was measured, and the sum of the distances of the points was determined. (NCT01301079)
Timeframe: 24 hours after the procedure
Intervention | centimeter (Mean) |
---|---|
Ketamine | 10.61 |
Saline | 11.82 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure
Intervention | kilogram force/second (Mean) |
---|---|
Ketamine | 3.5 |
Saline | 3.7 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure
Intervention | kilogram force/second (Mean) |
---|---|
Ketamine | 0.56 |
Saline | 0.51 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the postoperative period (24h after the procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24h after the procedure
Intervention | gram (Mean) |
---|---|
Ketamine | 248 |
Saline | 205 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the postoperative period (24 hours after procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24 hours after procedure
Intervention | gram (Mean) |
---|---|
Ketamine | 290 |
Saline | 247 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the surgery)
Intervention | kilogram force/second (Mean) |
---|---|
Ketamine | 3.6 |
Saline | 3.9 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the procedure)
Intervention | kilogram force/second (Mean) |
---|---|
Ketamine | 2.51 |
Saline | 2.19 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)
Intervention | gram (Mean) |
---|---|
Ketamine | 279 |
Saline | 269 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)
Intervention | gram (Mean) |
---|---|
Ketamine | 300 |
Saline | 300 |
(NCT01301079)
Timeframe: 24 hours
Intervention | milligram (Mean) |
---|---|
Ketamine | 27.40 |
Saline | 27.70 |
The scale measure pain after 12 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 12 hours
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 1.6 |
Saline | 1.4 |
The scale measure pain after 120 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 120 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 2.2 |
Saline | 2.0 |
The scale measure pain after 150 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 150 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 1.4 |
Saline | 1.4 |
The scale measure pain after 18 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 18 hours
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 1.5 |
Saline | 1.3 |
The scale measure pain after 180 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 180 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 1.1 |
Saline | 1.3 |
The scale measure pain after 210 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 210 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 0.9 |
Saline | 1.2 |
The scale measure pain after 24 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 24 hours
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 1.4 |
Saline | 0.8 |
The scale measure pain after 240 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 240 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 1.0 |
Saline | 1.1 |
The scale measure pain after 30 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 30 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 5.5 |
Saline | 6.2 |
The scale measure pain after 6 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 6 hours
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 0.9 |
Saline | 0.7 |
The scale measure pain after 60 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 60 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 4.6 |
Saline | 5.1 |
The scale measure pain after 90 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 90 minutes
Intervention | units on a scale (Mean) |
---|---|
Ketamine | 3.4 |
Saline | 3.4 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 8.6 |
Saline | 5.0 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-10 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5h after the procedure
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 9.1 |
Saline | 5.5 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 7.8 |
Saline | 1.9 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 24.1 |
Saline | 24.8 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 29.3 |
Saline | 34.8 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 3.3 |
Saline | 2.1 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 6.0 |
Saline | 4.5 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 8.0 |
Saline | 11.3 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
Intervention | picogram/milliliter (Mean) |
---|---|
Ketamine | 3.3 |
Saline | 2.2 |
(NCT01301079)
Timeframe: 24 hours
Intervention | minutes (Median) |
---|---|
Ketamine | 18 |
Saline | 15 |
Determine which of three different TAP formulations (Placebo, TAP, Clo-TAP) has the most beneficial effect on the postoperative area of hyperalgesia 48hrs after the start of the cesarean section. The smaller the area of WHA, assessed in cm2, the better the outcome. Area sizes may range from 0 to any size. (NCT01015807)
Timeframe: 48hrs after CS
Intervention | cm^2 (Mean) |
---|---|
Placebo | 1.07 |
TAP (Bupi) | 1.27 |
Clo-TAP (Bupi + Clon) | 0.74 |
OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)
Intervention | units on a scale (Mean) | ||||||
---|---|---|---|---|---|---|---|
Pretreatment | 30 min prior to REM infusion | 15 min after start of REM infusion | 40 min after start of REM infusion | 5 minutes after finish of REM infusion | 15 minutes after finish of REM infusion | 75 minutes after finish of REM infusion | |
Placebo | 1.1 | 1.1 | 0.8 | 0.5 | 1.8 | 2.1 | 1.6 |
Propranolol | 1.2 | 1.1 | 0.1 | 0.8 | 3 | 2.8 | 1.7 |
A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion
Intervention | percentage of change (Number) | |
---|---|---|
15 min post remifentanil infusion | 60 min post remifentanil infusion | |
Placebo | -34 | 141.5 |
Propranolol | -28 | -19 |
The CY-BOCS is a semi-structured measure of OCD severity with excellent inter-rater reliability, internal consistency, and test-retest reliability. It is validated in those starting at age 7 and used in studies up to age 20. The CYBOCS differs from the adult YBOCS only in its use of simpler language. The CY-BOCS consists of 10 items which are summed up to derive the total CY-BOCS score. The total score ranges from 0-40 with higher scores indicating greater severity of OCD symptoms. (NCT02422290)
Timeframe: Screening, Baseline, Day 7, Day 17, 3-Month; Baseline and Day 14 pre-specified to be reported
Intervention | score on a scale (Mean) | |
---|---|---|
CY-BOCS Baseline | CY-BOCS Day 14 | |
Ketamine Treatment Group | 29.00 | 26.20 |
The CGI-S is a clinician rated 7-point rating scale for the severity of a participant's illness relative to the clinician's experience of working with this particular population. The score ranges from 1-7 with higher scores indicating greater illness severity. (NCT02422290)
Timeframe: Screening, Baseline, Day 7, Day 17, 3-Month; Baseline and Day 14 pre-specified to be reported
Intervention | score on a scale (Mean) | |
---|---|---|
CGI-S Baseline | CGI-S Day 14 | |
Ketamine Treatment Group | 5.80 | 5.00 |
"The OCD-VAS is a one-item unipolar scale to assess OCD symptoms over a rapid time frame (No obsessions to Constant obsessions). The scale ranges from 0-10 with higher scores indicating higher presence of obsessions." (NCT02422290)
Timeframe: Screening, Baseline, Day 1-14, 3-Month; Baseline and Day 14 pre-specified to be reported
Intervention | score on a scale (Mean) | |
---|---|---|
OCD-VAS Baseline | OCD-VAS Day 14 | |
Ketamine Treatment Group | 5.00 | 5.00 |
"The Y-BOCCS is self-report scale which assesses OCD symptoms on a 5-point likert scale (None to Extreme). It consists of 10 items which are summed up to derive the total Y-BOCCS score. The total score ranges from 0-40 with higher scores indicating higher prevalence of OCD symptoms." (NCT02422290)
Timeframe: Screening, Baseline, Day 1-14, 3-Month; Baseline and Day 14 pre-specified to be reported
Intervention | score on a scale (Mean) | |
---|---|---|
Y-BOCCS Baseline | Y-BOCCS Day 14 | |
Ketamine Treatment Group | 18.25 | 16.50 |
Length of stay at postanesthesia recovery room (NCT02571153)
Timeframe: During the stay at postanesthesia recovery room (about 90 to 120 minutes)
Intervention | minutes (Mean) |
---|---|
Saline Group | 82.9 |
Ketamine 0.2 | 84.5 |
Ketamine 0.4 | 86 |
Morphine consumption (mg) at PACU (about 90 to 120 minutes) (NCT02571153)
Timeframe: During the stay at postanesthesia recovery room (about 90 to 120 minutes)
Intervention | mg (Mean) |
---|---|
Saline Group | 1.6 |
Ketamine 0.2 | 0.9 |
Ketamine 0.4 | 1.1 |
Occurrence of pain at the PACU. Average Pain will be calculated. The pain score will be evaluated using a 0-10 numeric pain rating scale, where zero mean no pain and 10 the worst imaginable pain. (NCT02571153)
Timeframe: 90 minutes postanesthesia at recovery room
Intervention | units on a scale (Mean) |
---|---|
Saline Group | 3.8 |
Ketamine 0.2 | 2.6 |
Ketamine 0.4 | 2.8 |
Percentage of participants with postoperative nausea and vomiting at the PACU and during the hospital ward stay (NCT02571153)
Timeframe: 24 hours
Intervention | percentage of participants (Number) |
---|---|
Saline Group | 30.8 |
Ketamine 0.2 | 29.7 |
Ketamine 0.4 | 39.5 |
Percentage of Participants with Tramadol during the ward stay (NCT02571153)
Timeframe: 24 hours
Intervention | percentage of participants (Number) |
---|---|
Saline Group | 5.1 |
Ketamine 0.2 | 10.8 |
Ketamine 0.4 | 13.9 |
Quality of postoperative functional recovery assessed by the questionnaire QoR40 The quality of postoperative functional recovery was assessed by the QoR-40 questionnaire, which assesses five dimensions of recovery (physical comfort - 12 items; emotional state - 7 items; physical independence - 5 items; physiological support - 7 items; and pain - 7 items). Each item was rated on a five-point Likert scale: none of the time, some of the time, usually, most of the time, and all the time. The total score on the QoR-40 ranges from 40 (poorest quality of recovery) to 200 (best quality of recovery). The QoR-40 was administered by a blind investigator 24 hours after surgery. (NCT02571153)
Timeframe: 24 hours
Intervention | units on a scale (Mean) |
---|---|
Saline Group | 187.8 |
Ketamine 0.2 | 189.6 |
Ketamine 0.4 | 186.8 |
"The severity of postoperative pain was rated the higher score of pain (NRS) during the hospital ward stay.~Pain was evaluated using a 0-10 numeric pain rating scale (NRS), where zero meant no pain and 10 the worst imaginable pain." (NCT02571153)
Timeframe: 24 hours
Intervention | units on a scale (Mean) |
---|---|
Saline Group | 3.2 |
Ketamine 0.2 | 2.8 |
Ketamine 0.4 | 3.6 |
"Patient-reported pain scores on numerical rating scale (NRS) -11 pain scale (where 0 indicates no pain at all, 10 indicates the most severe pain). Initial group were patients enrolled and randomized in to the study, assessments were taken at the time of enrollment/randomization in to the study (up to 20 min prior to T=0). T = 0 min assessments were conducted at the time of medication administration (study allowed for an up to 20-minute delay in receiving study drug in order to retrieve study drug from secure storage, nursing documentation and patient verification prior to administration)." (NCT02489630)
Timeframe: 20 min pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration
Intervention | Units on a scale (1-10) (Mean) | |||||
---|---|---|---|---|---|---|
Initial | T = 0 min | T = 30 min | T = 60 min | T = 90 min | T = 120 min | |
Ketamine | 9.38 | 7.51 | 5.25 | 5.31 | 4.51 | 4.24 |
Placebo | 9.44 | 8.10 | 2.27 | 6.18 | 6.21 | 5.68 |
Patient-reported score regarding satisfaction with pain control, reported on a 4-point Likert scale (1-4, where 1 is the lowest satisfaction score possible and 4 is the highest satisfaction score possible). No data is reported for T = 0 min, as that assessment was conducted concurrently with initial medication dosing (since patients were at that point receiving their first pain control efforts, they could not yet assess their satisfaction with those efforts). (NCT02489630)
Timeframe: 0 min, 30 min, 60 min, 90 min, 120 min post medication administration
Intervention | Units on a scale (1-4) (Mean) | |||
---|---|---|---|---|
T = 30 min | T = 60 min | T = 90 min | T = 120 min | |
Ketamine | 2.09 | 2.38 | 2.54 | 2.66 |
Placebo | 2.27 | 2.33 | 2.38 | 2.52 |
"Average difference in opiate dosage between study arms, calculated in morphine equivalents. Initial indicates at first dose of opioid administration, up to 20 mins prior to study drug administration, and from 0 min to 120 min after study drug administration." (NCT02489630)
Timeframe: 20 mins pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration
Intervention | Milligrams of Morphine Equivalent (Mean) | |
---|---|---|
Initial Narcotic Dosage | Total Narcotic Dosage | |
Ketamine | 5.41 | 9.95 |
Placebo | 5.83 | 12.81 |
12 reviews available for ketamine and Allodynia
Article | Year |
---|---|
Perioperative ketamine for postoperative pain management in patients with preoperative opioid intake: A systematic review and meta-analysis.
Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2022 |
Ketamine; history and role in anesthetic pharmacology.
Topics: Analgesics, Opioid; Anesthetics; Humans; Hyperalgesia; Ketamine; Phencyclidine; Remifentanil | 2022 |
Efficacy of ketamine in relieving neuropathic pain: a systematic review and meta-analysis of animal studies.
Topics: Animals; Hyperalgesia; Ketamine; Mice; Neuralgia; Rats | 2021 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
NMDA receptor antagonists and pain relief: A meta-analysis of experimental trials.
Topics: Acute Pain; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Mod | 2019 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
[Ketamine revisited].
Topics: Analgesics; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2010 |
[Prevention of postoperative hyperalgesia].
Topics: Amantadine; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Excit | 2012 |
Ketamine, revival of a versatile intravenous anaesthetic.
Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; H | 2003 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
Something new about ketamine for pediatric anesthesia?
Topics: Analgesia; Anesthesia; Anesthetics, Dissociative; Animals; Humans; Hyperalgesia; Inflammation; Ketam | 2008 |
47 trials available for ketamine and Allodynia
Article | Year |
---|---|
Preventative effect of ketamine on post-surgical hyperalgesia induced at a body part remote from the surgical site.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Hyperalgesia; Hysterectomy; Intraoperative C | 2018 |
Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy.
Topics: Acute Disease; Administration, Intravenous; Adult; Analgesia, Epidural; Analgesics; Chronic Pain; Co | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Child; Double-Blind Method; Drug Toleranc | 2014 |
Study protocol for a randomised, double-blinded, placebo-controlled, clinical trial of S-ketamine for pain treatment in patients with chronic pancreatitis (RESET trial).
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Blind Method; Humans; Hyp | 2015 |
Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cholecystectomy, Laparoscopic; | 2015 |
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The ED50 and ED95 of ketamine for prevention of postoperative hyperalgesia after remifentanil-based anaesthesia in patients undergoing laparoscopic cholecystectomy.
Topics: Analgesics; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; Dose-Response Relationship, Dru | 2011 |
A comparison of ketamine and paracetamol for preventing remifentanil induced hyperalgesia in patients undergoing total abdominal hysterectomy.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Female; Humans; Hyperalgesia; Hysterectomy; Ketamine; Midd | 2012 |
Low-dose sublingual ketamine does not modulate experimentally induced mechanical hyperalgesia in healthy subjects.
Topics: Administration, Sublingual; Adult; Analgesics; Double-Blind Method; Female; Humans; Hyperalgesia; Ke | 2012 |
Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo.
Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Double-Blind Meth | 2003 |
Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans.
Topics: Adult; Analgesics, Opioid; Blood Gas Analysis; Cross-Over Studies; Double-Blind Method; Drug Interac | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor.
Topics: Adult; Area Under Curve; Attention; Cross-Over Studies; Double-Blind Method; Electric Stimulation; E | 2004 |
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Bli | 2004 |
Effect of pre-emptive ketamine on sensory changes and postoperative pain after thoracotomy: comparison of epidural and intramuscular routes.
Topics: Adult; Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dou | 2004 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia.
Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Dissociative; Area Under Curve; C | 2006 |
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti | 2006 |
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti | 2006 |
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti | 2006 |
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti | 2006 |
Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Dose-Response Relationship, Radiation; Excitatory A | 2007 |
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-B | 2007 |
Pharmacological dissection of the paradoxical pain induced by a thermal grill.
Topics: Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagon | 2008 |
Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT.
Topics: Adult; Aged; Anesthetics, Dissociative; Brain; Cysteine; Female; Fibromyalgia; Follow-Up Studies; Hu | 2007 |
Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.
Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; | 1994 |
Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia.
Topics: Adult; Analgesia; Double-Blind Method; Female; Fentanyl; Humans; Hyperalgesia; Ketamine; Middle Aged | 1994 |
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind | 1995 |
Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Dissociative; Burns; Dose-Response Relationship, Drug; | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study.
Topics: Adult; Anesthetics, Dissociative; Capsaicin; Double-Blind Method; Electric Stimulation; Electrophysi | 1996 |
Local treatment with the N-methyl-D-aspartate receptor antagonist ketamine, inhibit development of secondary hyperalgesia in man by a peripheral action.
Topics: Adult; Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Male; | 1997 |
A new method to evaluate central sensitization to pain following surgery. Effect of ketamine.
Topics: Action Potentials; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Dissociative; Dermatolo | 1997 |
Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo.
Topics: Adult; Analgesics, Opioid; Burns; Cross-Over Studies; Depression, Chemical; Double-Blind Method; Exc | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Capsaicin; Cognition; | 1998 |
The effect of naloxone on ketamine-induced effects on hyperalgesia and ketamine-induced side effects in humans.
Topics: Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Male; Naloxone; Narcotic An | 1999 |
The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction.
Topics: Adult; Analgesics; Analgesics, Opioid; Axons; Capsaicin; Erythema; Female; Fentanyl; Humans; Hyperal | 1999 |
Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans.
Topics: Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Hot Temperature; | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man.
Topics: Adult; Analgesics; Analgesics, Opioid; Burns; Cross-Over Studies; Double-Blind Method; Excitatory Am | 2000 |
Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans.
Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Me | 2000 |
Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain.
Topics: Adult; Aged; Aged, 80 and over; Alfentanil; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2001 |
'Balanced analgesia' in the perioperative period: is there a place for ketamine?
Topics: Aged; Analgesia; Analgesics; Analysis of Variance; Female; Humans; Hyperalgesia; Ketamine; Male; Mid | 2001 |
A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Ax | 2001 |
Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Dose-Response Re | 2002 |
92 other studies available for ketamine and Allodynia
Article | Year |
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Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Female; Humans; Hyperalgesia; Ketamine; Leukemia, Promyelocy | 2022 |
Response After Repeated Ketamine Injections in a Rat Model of Neuropathic Pain.
Topics: Animals; Hyperalgesia; Ketamine; Male; Neuralgia; Pain Measurement; Rats; Rats, Wistar; Sciatic Nerv | 2022 |
Suspected opioid-induced hyperalgesia in an infant following surgery: A case report.
Topics: Adult; Analgesics, Opioid; Fentanyl; Humans; Hyperalgesia; Infant; Ketamine; Male; Pain | 2022 |
The use of ketamine infusion to dramatically reduce opioid requirements in a patient whose high-dose intrathecal opioid pump was inadvertently cut during surgery.
Topics: Analgesics, Opioid; Chronic Pain; Humans; Hyperalgesia; Infusions, Intravenous; Ketamine; Morphine | 2023 |
A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons.
Topics: Animals; Cyclooxygenase 2; Fentanyl; Hyperalgesia; Inflammation; Ketamine; Neurons; NF-kappa B; Rats | 2023 |
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2020 |
Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia.
Topics: Analgesics, Opioid; Animals; Ankle Joint; Brain; Brain Stem; Chronic Pain; Diencephalon; Disease Mod | 2020 |
Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
Topics: Acute Pain; Analgesics; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Comb | 2020 |
Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone: modulation by acute ketamine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Tolerance; Excitatory Amino Acid Antagonists; Hy | 2020 |
Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia.
Topics: Administration, Cutaneous; Aged; Analgesics; Baclofen; Drug Synergism; Humans; Hyperalgesia; Ketamin | 2017 |
Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine.
Topics: Aged; Analgesics; Female; Hepatectomy; Humans; Hyperalgesia; Incidence; Ketamine; Male; Middle Aged; | 2017 |
Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Disease Models, An | 2017 |
Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Conditioning, Operant; Dizocilpine Maleate; Dose-Response R | 2018 |
Ketamine and remote hyperalgesia.
Topics: Double-Blind Method; Human Body; Humans; Hyperalgesia; Ketamine; Receptors, N-Methyl-D-Aspartate | 2018 |
Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis | 2018 |
Ketamine has anti-hyperalgesic effects and relieves acute pain, but does not prevent persistent postoperative pain (PPP).
Topics: Acute Pain; Analgesics; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2015 |
The effect of ketamine on delirium and opioid-induced hyperalgesia in the Intensive Care Unit.
Topics: Analgesics, Opioid; Critical Care; Delirium; Humans; Hyperalgesia; Hypnotics and Sedatives; Intensiv | 2018 |
Prevention of post-operative hyperalgesia in a heroin-addicted patient on methadone maintenance.
Topics: Analgesics, Opioid; Heroin; Humans; Hyperalgesia; Ketamine; Male; Methadone; Middle Aged; Opioid-Rel | 2019 |
Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice.
Topics: Analgesics; Animals; Behavior, Animal; Caveolin 1; Depression; Disease Models, Animal; Freund's Adju | 2020 |
The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, D | 2018 |
Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine.
Topics: Analgesics; Animals; Disease Models, Animal; Hemorrhage; Hyperalgesia; Ketamine; Pain Measurement; R | 2013 |
Influence of clonidine and ketamine on m-RNA expression in a model of opioid-induced hyperalgesia in mice.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Brain; Clonidine; Disease M | 2013 |
Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization.
Topics: Activating Transcription Factor 3; Analysis of Variance; Animals; Cytokines; Ganglia, Spinal; Hot Te | 2014 |
Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Behavior, Animal; Buprenorphine; Hyperalgesia; | 2015 |
Long-Term Antihyperalgesic and Opioid-Sparing Effects of 5-Day Ketamine and Morphine Infusion ("Burst Ketamine") in Diabetic Neuropathic Rats.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; | 2015 |
Phosphorylation of the GluN1 subunit in dorsal horn neurons by remifentanil: a mechanism for opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Female; Hyperalgesia; Ketamine; Naloxone; Nerve Tissue Proteins; Phosph | 2015 |
Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Disease; Complex Regional Pain Syndromes; Disease Mod | 2015 |
Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Hyperalgesia; Ketamine; Male; Meth | 2015 |
Ketamine for pain management in France, an observational survey.
Topics: Acute Pain; Aged; Anesthetics, Dissociative; Chronic Pain; Female; France; Health Care Surveys; Huma | 2015 |
Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Freund's Adjuv | 2016 |
A comparison of intrathecal magnesium and ketamine in attenuating remifentanil-induced hyperalgesia in rats.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Ketamine; Magnesium Sul | 2016 |
Effects of norketamine enantiomers in rodent models of persistent pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Dr | 2008 |
Selective disturbance of pain sensitivity after social isolation.
Topics: Analgesics; Animals; Animals, Newborn; Carrageenan; Disease Models, Animal; Hot Temperature; Hyperal | 2009 |
[Ketamine for prevention of postoperative pain: what are the doses and indications?].
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; | 2009 |
Propofol alters ketamine effect on opiate-induced hyperalgesia.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Drug Interactions; Drug Tolerance; Humans; | 2009 |
Expert panel guidelines (2008). Postoperative pain management in adults and children. SFAR Committees on Pain and Local Regional Anaesthesia and on Standards.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics, Non-Narcoti | 2009 |
Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation: role of nitric oxide.
Topics: Animals; Carrageenan; Electroacupuncture; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hot | 2009 |
[Effects of general anesthesia using ketamine and remifentanil on postoperative pain management for patients undergoing laparotomy].
Topics: Adult; Aged; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Elective Surgical Procedu | 2009 |
S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.
Topics: Adolescent; Adult; Algorithms; Anesthetics, Dissociative; Cardiac Output; Dose-Response Relationship | 2009 |
Spinally applied ketamine or morphine attenuate peripheral inflammation and hyperalgesia in acute and chronic phases of experimental arthritis.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Animals; Arthritis, Experimental; Chronic Disease; Fe | 2010 |
Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2010 |
Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Aci | 2009 |
Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models.
Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intrad | 2010 |
Opioid-induced hyperalgesia: low-dose ketamine does work for some orthopaedic problems already.
Topics: Analgesics, Opioid; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Orthopedic Pr | 2010 |
Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain.
Topics: 2-Aminoadipic Acid; Analgesics; Animals; Astrocytes; Dose-Response Relationship, Drug; Drug Therapy, | 2010 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glut | 2010 |
Buprenorphine-induced hyperalgesia in the rat.
Topics: Analgesics; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Administration Schedule; | 2011 |
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain.
Topics: Analgesics; Animals; Astrocytes; Behavior, Animal; Enzyme Activation; Hyperalgesia; Injections, Spin | 2011 |
Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain.
Topics: Analgesics; Analysis of Variance; Animals; CD11b Antigen; Cell Count; Disease Models, Animal; Dose-R | 2011 |
Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Cold Temperature; Data Interpretation, Statisti | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids; | 2011 |
Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion.
Topics: Analgesics, Opioid; Humans; Hydromorphone; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Mid | 2012 |
Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Carrageenan; Disease Models, Animal; Excitatory A | 2011 |
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; E | 2011 |
A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats.
Topics: Anesthetics, Dissociative; Animals; Antidepressive Agents; Behavior, Animal; Cold Temperature; Corti | 2011 |
Suspected opioid-induced hyperalgesia in an infant.
Topics: Abdominal Wall; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Dexmedetomi | 2012 |
Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain.
Topics: Analgesia; Analgesics; Animals; Cells, Cultured; Hyperalgesia; Ketamine; Male; Mice; Mice, Transgeni | 2011 |
Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Hyperalgesia; | 2013 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat.
Topics: Administration, Topical; Amitriptyline; Anesthetics, Dissociative; Animals; Antidepressive Agents, T | 2003 |
Effect of long-term ketamine administration on vocalization to paw pressure and on spinal wind-up activity in monoarthritic rats.
Topics: Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Arthritis, Infectious; Chronic D | 2003 |
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal | 2004 |
Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Drug Interactions; Excitatory Amino Acid Antag | 2004 |
Preventive analgesia to reduce wound hyperalgesia and persistent postsurgical pain: not an easy path.
Topics: Analgesia, Epidural; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2005 |
[Comparison of the suppressive effects of tramadol and low-dose ketamine on the patients with postoperative hyperalgesia after remifentanil-based anaesthesia].
Topics: Adult; Analgesics, Opioid; Anesthesia; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Post | 2005 |
A single dose of intrathecal morphine in rats induces long-lasting hyperalgesia: the protective effect of prior administration of ketamine.
Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Spinal; Ketamine; Male; Morphi | 2005 |
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Aci | 2006 |
Characterization of the antinociceptive effect of oxycodone in male and female rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2006 |
An evaluation of a polyamine-deficient diet for the treatment of inflammatory pain.
Topics: Analgesia; Analgesics; Animals; Carrageenan; Diet; Hindlimb; Hyperalgesia; Inflammation; Ketamine; M | 2006 |
Opioid-induced hyperalgesia.
Topics: Analgesics; Analgesics, Opioid; Femoral Artery; Fentanyl; Humans; Hyperalgesia; Ketamine; Male; Midd | 2007 |
Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification - evidence of central sensitization.
Topics: Adult; Analgesics; Electric Stimulation; Esophagus; Evoked Potentials; Female; Humans; Hydrogen-Ion | 2007 |
Ketamine as an adjuvant for treatment of cancer pain in children and adolescents.
Topics: Adolescent; Age Factors; Analgesics, Opioid; Child; Child, Preschool; Dose-Response Relationship, Dr | 2007 |
Ketamine blocks enhancement of spinal long-term potentiation in chronic opioid treated rats.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Animals; Chronic Disease; Drug Synergism; Electric St | 2008 |
The effect of abdominal surgery on thresholds to thermal and mechanical stimulation in sheep.
Topics: Abdomen; Animals; Female; Hot Temperature; Hyperalgesia; Ketamine; Pain Threshold; Postoperative Per | 1995 |
Evidence of a role for N-methyl-D-aspartate (NMDA) receptors in the facilitation of tail withdrawal after spinal transection.
Topics: Analgesics; Animals; Cordotomy; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; | 1994 |
Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy.
Topics: Animals; Behavior, Animal; Cold Temperature; Dose-Response Relationship, Drug; Excitatory Amino Acid | 1996 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |
Reduction in hyperalgesia and intrathecal morphine requirements by low-dose ketamine infusion.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Humans; Hyp | 1997 |
Antinociceptive effect of the S(+)-enantiomer of ketamine on carrageenan hyperalgesia after intrathecal administration in rats.
Topics: Analgesics; Anesthetics, Dissociative; Animals; Carrageenan; Hyperalgesia; Injections, Spinal; Ketam | 1998 |
Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat.
Topics: Anesthetics, Dissociative; Animals; Female; Hyperalgesia; Injections, Spinal; Ketamine; Nerve Compre | 1998 |
[Suppressive effects of ketamine on neuropathic pain].
Topics: Acute Disease; Anesthetics, Dissociative; Animals; Disease Models, Animal; Dose-Response Relationshi | 1998 |
Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists.
Topics: Analgesics; Animals; Biphenyl Compounds; Excitatory Amino Acid Antagonists; Gene Expression Regulati | 1999 |
Generalized hyperalgesia and allodynia following abrupt cessation of subcutaneous ketamine infusion.
Topics: Aged; Analgesics; Breast Neoplasms; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections | 1999 |
Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fe | 2000 |
Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation.
Topics: Adrenergic alpha-Antagonists; Analgesia; Analgesics; Animals; Carrageenan; Drug Administration Sched | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An | 2000 |
Treatment of central post-stroke pain with oral ketamine.
Topics: Administration, Oral; Aged; Analgesics; Female; Humans; Hyperalgesia; Ketamine; Neuralgia; Stroke | 2001 |
Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model.
Topics: Analgesia; Analgesics; Animals; Formaldehyde; Hyperalgesia; Injections, Intravenous; Injections, Spi | 2001 |
Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor.
Topics: Analgesia, Patient-Controlled; Analgesics; Brain Stem; Cervical Vertebrae; Child; Diazepam; Drug Res | 2001 |
The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Excitatory Amino Acid Antagonists; Fentanyl; Hyperalges | 2002 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; C | 1992 |