Page last updated: 2024-10-29

ketamine and Allodynia

ketamine has been researched along with Allodynia in 151 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
"Adding epidural or IV racemic ketamine to TEA after thoracotomy did not lead to any reduction in PPP or allodynia."9.19Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy. ( Gomar, C; Rios, J; Tena, B, 2014)
"Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery."9.19Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014)
" A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown."9.19Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014)
"The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine."9.12Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007)
" This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on human neuropathic pain states, characterized by allodynia and hyperalgesia."9.09Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. ( Leung, A; Ridgeway, B; Wallace, MS; Yaksh, T, 2001)
"Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0."9.08NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996)
"To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia."8.98Perioperative intravenous ketamine for acute postoperative pain in adults. ( Bell, RF; Brinck, EC; Heesen, M; Kontinen, V; Moore, RA; Straube, S; Tiippana, E, 2018)
"This review discusses the place of the old anesthetic ketamine in pediatric anesthesia."8.84Something new about ketamine for pediatric anesthesia? ( De Kock, M; Lois, F, 2008)
"Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain."8.12Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022)
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics."7.96Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020)
"In CFA-treated mice that exhibited pain behavior and depression-like behavior, ketamine reversed depression-like behavior."7.96Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice. ( Han, R; Han, S; Li, J; Peng, Y; Sun, W; Wang, J; Zhao, Q; Zhou, Y, 2020)
"Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France."7.81Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015)
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression."7.77A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011)
"Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain."7.75S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009)
"Case report of 68 year old female with central post-stroke pain successfully treated with oral ketamine."7.71Treatment of central post-stroke pain with oral ketamine. ( Lamer, TJ; Vick, PG, 2001)
"These results demonstrated that ketamine produced antinociceptive effects through an activation of the monoaminergic descending inhibitory system, whereas, in a unilateral peripheral inflammation-induced hyperalgesic state, the monoaminergic system did not contribute to the antihyperalgesic effects of ketamine."7.70Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation. ( Kawamata, M; Kawamata, T; Namiki, A; Omote, K; Sonoda, H, 2000)
" To reduce the risk for potential psychodysleptic side effects, however, ketamine dosing tends to be limited to low-dose regimens."6.82The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016)
"Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain."6.71Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003)
"The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil."6.68Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995)
"Ketamine is an NMDA-blocking agent widely used in human medicine."6.67Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994)
"Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine."5.91A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023)
"Depression is present in a large proportion of patients suffering from chronic pain, and yet the underlying mechanisms remain to be elucidated."5.48Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression. ( Ji, MH; Li, HH; Li, KY; Pan, W; Yang, JJ; Zhang, GF; Zhou, ZQ, 2018)
"Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management."5.48The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain. ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018)
"heat allodynia) followed by a persistent area of secondary tactile allodynia."5.36Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010)
"It had less effect on tactile allodynia (CCI)."5.35Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008)
"Thus, transgenic mice exhibited mechanical allodynia."5.30Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists. ( Cuello, AC; Henry, JL; Julien, JP; McLeod, AL; Ribeiro-Da-Silva, A; Ritchie, J, 1999)
"Primary outcomes were postoperative acute pain at rest/during movement after 24 h and number of patients with ketamine-related adverse events."5.22Perioperative ketamine for postoperative pain management in patients with preoperative opioid intake: A systematic review and meta-analysis. ( Kranke, P; Lipke, E; Meyer-Frießem, CH; Pogatzki-Zahn, EM; Reichl, S; Schnabel, A; Weibel, S; Zahn, PK, 2022)
"The measurements were postoperative pain intensity during 24 hours; morphine consumption; time to first morphine supplementation; hyperalgesia (using monofilaments and an algometer) and allodynia (using a soft brush) in the thenar eminence of the nondominant hand and in the periumbilical region 24 hours after surgery; extent of hyperalgesia using a 300-g monofilament near the periumbilical region 24 hours after surgery; and serum levels of IL-6, IL-8, and IL-10."5.20Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study. ( Brunialti, MK; Leal, PC; Sakata, RK; Salomão, R, 2015)
"Adding epidural or IV racemic ketamine to TEA after thoracotomy did not lead to any reduction in PPP or allodynia."5.19Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy. ( Gomar, C; Rios, J; Tena, B, 2014)
"Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery."5.19Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014)
" A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown."5.19Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014)
"The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine."5.12Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007)
"The results of the present study demonstrate that pre-emptive epidural ketamine is effective in reducing intra- and postoperative analgesic requirements, hyperalgesia and touch allodynia."5.11Effect of pre-emptive ketamine on sensory changes and postoperative pain after thoracotomy: comparison of epidural and intramuscular routes. ( Andersen, OK; Arendt-Nielsen, L; Camlica, H; Dereli, N; Ozyalcin, NS; Yucel, A, 2004)
" This study tested the hypotheses that increased pain sensitivity assessed by periincisional allodynia and hyperalgesia can occur after relatively large-dose intraoperative remifentanil and that small-dose ketamine prevents this hyperalgesia."5.11Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. ( Chauvin, M; Fletcher, D; Guignard, B; Joly, V; Maurette, P; Richebe, P; Sessler, DI, 2005)
" This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on human neuropathic pain states, characterized by allodynia and hyperalgesia."5.09Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. ( Leung, A; Ridgeway, B; Wallace, MS; Yaksh, T, 2001)
" Alfentanil effectively inhibited electrically evoked pain and reduced pin prick hyperalgesia and allodynia during its infusion."5.09A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. ( Albrecht, S; Dern, SK; Koppert, W; Schmelz, M; Schüttler, J; Sittl, R, 2001)
"Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0."5.08NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996)
"In a double-blind, controlled trial, we administered doses of an opioid analgesic (alfentanil), an N-methyl-D-aspartate receptor antagonist (ketamine), or their combination to normal volunteers and found no advantage of the combination over a larger dose of either drug alone in relieving pain caused by painful chemical stimulation."5.08Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. ( Bennett, GJ; Gracely, R; Liu, M; Max, MB; Sethna, NF, 1998)
"To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia."4.98Perioperative intravenous ketamine for acute postoperative pain in adults. ( Bell, RF; Brinck, EC; Heesen, M; Kontinen, V; Moore, RA; Straube, S; Tiippana, E, 2018)
"This review discusses the place of the old anesthetic ketamine in pediatric anesthesia."4.84Something new about ketamine for pediatric anesthesia? ( De Kock, M; Lois, F, 2008)
"Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain."4.12Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022)
" His pain and agitation were difficult to manage but improved after he received ketamine."4.12Suspected opioid-induced hyperalgesia in an infant following surgery: A case report. ( Efune, PN; Rebstock, SE, 2022)
" Osteoarthritis was induced in male adult control Wistar rats without any interventions and in Wisket rats after juvenile social isolation and ketamine treatment."3.96Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia. ( Banki, L; Büki, A; Horvath, G; Jancsó, G; Kekesi, G; Kis, G; Somogyvári, F; Tuboly, G; Varga, E; Vécsei, L, 2020)
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics."3.96Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020)
"In CFA-treated mice that exhibited pain behavior and depression-like behavior, ketamine reversed depression-like behavior."3.96Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice. ( Han, R; Han, S; Li, J; Peng, Y; Sun, W; Wang, J; Zhao, Q; Zhou, Y, 2020)
"Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France."3.81Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015)
"We report the successful use of low-dose ketamine infusion for treating a severe episode of painful myoclonus in the lower extremities, associated with opioid-induced hyperalgesia (OIH), in a patient who was receiving long-term, high dose intrathecal hydromorphone therapy."3.78Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion. ( Chan, PS; Forero, M; Restrepo-Garces, CE, 2012)
" The effects of ketamine on SNL-induced mechanical allodynia were confirmed by behavioral testing."3.77Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain. ( Li, YQ; Mei, XP; Wang, W; Wei, YY; Xu, LX; Zhai, MZ; Zhang, H, 2011)
"Ketamine, its active metabolite norketamine, and the NR2B-selective antagonist traxoprodil (CP-101,606) were tested in rat models of acute antinociception (paw-withdrawal response to heat) and chronic neuropathic pain (spared nerve injury)."3.77Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain. ( Aarts, L; Dahan, A; Morariu, A; Niesters, M; Swartjes, M, 2011)
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression."3.77A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011)
"Intrathecal ketamine (10, 100, 1000 μg/kg) or LAA (10, 50, 100 nmol) alleviated SNL-induced mechanical allodynia in a dose-dependent manner respectively."3.76Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain. ( Chen, L; Li, YQ; Mei, XP; Wang, W; Wu, SX; Xu, LX; Zhang, T; Zhu, C, 2010)
"Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain."3.75S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009)
"04 mg/kg, subcutaneous) significantly enhanced mechanical allodynia and thermal hyperalgesia induced by the plantar incision during the postoperative period (each lasting between 2 h and 48 h), which was attenuated by pretreatment with ketamine (10 mg/kg, subcutaneous)."3.75Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine. ( Cui, S; Gu, X; Liu, Y; Ma, Z; Wu, X, 2009)
"Case report of 68 year old female with central post-stroke pain successfully treated with oral ketamine."3.71Treatment of central post-stroke pain with oral ketamine. ( Lamer, TJ; Vick, PG, 2001)
"These results demonstrated that ketamine produced antinociceptive effects through an activation of the monoaminergic descending inhibitory system, whereas, in a unilateral peripheral inflammation-induced hyperalgesic state, the monoaminergic system did not contribute to the antihyperalgesic effects of ketamine."3.70Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation. ( Kawamata, M; Kawamata, T; Namiki, A; Omote, K; Sonoda, H, 2000)
"Ketamine is known to modulate hyperalgesia induced by central sensitization."2.87Preventative effect of ketamine on post-surgical hyperalgesia induced at a body part remote from the surgical site. ( Jeon, YJ; Kim, MH; Lee, HM; Moon, YE; Yoon, HM, 2018)
"Ketamine (Ket) was developed in 1962 as a less hallucinogenic and shorter acting agent than phencyclidine."2.82Ketamine; history and role in anesthetic pharmacology. ( Hirota, K; Lambert, DG, 2022)
" To reduce the risk for potential psychodysleptic side effects, however, ketamine dosing tends to be limited to low-dose regimens."2.82The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016)
"ketamine was ineffective."2.73Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system. ( Hopf, HC; Klein, T; Magerl, W; Nickel, U; Sandkühler, J; Treede, RD, 2007)
" The first analysis included 19 comparisons on a single ketamine dose and measurement of effect within 3 hours of dosing and showed an appreciable effect (standardized mean difference 1."2.72Efficacy of ketamine in relieving neuropathic pain: a systematic review and meta-analysis of animal studies. ( Dahan, A; Dahan, JDC; Hooijmans, CR; Mogil, JS; van Dorp, ELA; Velzen, MV, 2021)
"Both the intensity and unpleasantness of mechanical hyperalgesia was statistically significantly reduced by ketamine gel applied both on the left and right side."2.72Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia. ( Pöyhiä, R; Vainio, A, 2006)
"Parecoxib (40 mg) was administered intravenously either with onset of electrical stimulation (preventive) or in parallel to the remifentanil infusion."2.72Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. ( Koppert, W; Schmelz, M; Schüttler, J; Singler, B; Sittl, R; Tröster, A, 2006)
"Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain."2.71Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003)
"The ketamine infusion was started after baseline testing at a constant target concentration."2.71Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans. ( Arendt-Nielsen, L; Curatolo, M; Gerber, A; Luginbühl, M; Petersen-Felix, S; Schnider, TW, 2003)
"The magnitude of pain and area of hyperalgesia were assessed before, during, and after drug infusion (remifentanil at 0."2.71Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. ( Alsheimer, M; Koppert, W; Scheuber, K; Schmelz, M; Schüttler, J; Sittl, R, 2003)
"Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids."2.71Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. ( Angst, MS; Clark, DJ; Koppert, W; Pahl, I; Schmelz, M, 2003)
"Although postoperative pain measurements did not differ, postoperative epidural treatment (intravenous-epidural) was less effective to prevent residual pain at 1 yr (11%; P = 0."2.71Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. ( De Kock, M; Lavand'homme, P; Waterloos, H, 2005)
"Wound mechanical hyperalgesia was evaluated and residual pain was assessed by asking the patients at 2 weeks, and 1, 6, and 12 months."2.70'Balanced analgesia' in the perioperative period: is there a place for ketamine? ( De Kock, M; Lavand'homme, P; Waterloos, H, 2001)
"Ketamine is an NMDA-receptor antagonist and has proven effective in alleviating secondary hyperalgesia in humans."2.69The effect of naloxone on ketamine-induced effects on hyperalgesia and ketamine-induced side effects in humans. ( Borgbjerg, FM; Brennum, J; Dahl, JB; Ilkjaer, S; Mikkelsen, S, 1999)
"Ketamine failed to inhibit both secondary hyperalgesia and axon reflex flare as long as nonlocal anesthetic concentrations were applied."2.69The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction. ( Blunk, JA; Koppert, W; Likar, R; Schmelz, M; Sittl, R; Zeck, S, 1999)
"The area of secondary hyperalgesia was quantitated using punctate (von Frey filaments) and brush stimuli (electric brush)."2.69Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man. ( Jørum, E; Stubhaug, A; Warncke, T, 2000)
"Pain scores and areas of hyperalgesia were not affected when the contralateral site was infiltrated with ketamine or lidocaine."2.69Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans. ( Arendt-Nielsen, L; Bach, FW; Gottrup, H; Jensen, TS, 2000)
"The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil."2.68Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995)
"Ketamine caused an increase in the summation threshold compared to the placebo treatment."2.68The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study. ( Andersen, OK; Arendt-Nielsen, L; Bjerring, P; Felsby, S; Jensen, TS; Nicolaisen, L, 1996)
"Primary hyperalgesia was determined by measuring heat pain detection threshold (HPDT) within the site of injury."2.68Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 1997)
"Using punctuate mechanical hyperalgesia as a measure of central sensitization, we examined whether induction and maintenance of central sensitization after surgery could be prevented by a low-dose infusion of the NMDA-receptor antagonist ketamine."2.68Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. ( Breivik, H; Eide, PK; Foss, A; Kreunen, M; Stubhaug, A, 1997)
"Ketamine is an NMDA-blocking agent widely used in human medicine."2.67Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994)
"The surgical wound hyperalgesia was assessed by measuring pain threshold to pressure on the wound by using an algometer, and also by measuring the intensity of pain to suprathreshold pressure on the wound with the visual analog self-rating method."2.67Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. ( Bradley, EL; Finger, J; Isakson, A; Kissin, I; Oz, Y; Tverskoy, M, 1994)
"Three types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia."2.48[Prevention of postoperative hyperalgesia]. ( Mamie, C, 2012)
"Recent advances in the understanding of postoperative pain have demonstrated its association with sensitization of the central nervous system (CNS) which clinically elicits pain hypersensitivity."2.44The clinical role of NMDA receptor antagonists for the treatment of postoperative pain. ( De Kock, MF; Lavand'homme, PM, 2007)
"The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high."2.44Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007)
"Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine."1.91A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023)
"Ketamine was injected intraperitoneally daily for 4 weeks, discontinued for 2 weeks, and then readministered for 1 week."1.72Response After Repeated Ketamine Injections in a Rat Model of Neuropathic Pain. ( Choi, JB; Chung, HT; Kim, BG; Kim, NA; Kim, YS; Kwon, HR; Lee, J; Song, JH, 2022)
"capsaicin-induced thermal allodynia) are unknown."1.48Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys. ( Banks, ML; Cornelissen, JC; Nicholson, KL; Rice, KC; Steele, FF, 2018)
"Depression is present in a large proportion of patients suffering from chronic pain, and yet the underlying mechanisms remain to be elucidated."1.48Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression. ( Ji, MH; Li, HH; Li, KY; Pan, W; Yang, JJ; Zhang, GF; Zhou, ZQ, 2018)
"Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management."1.48The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain. ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018)
"Allodynia/hyperalgesia area did not differ between groups and was infrequent and slight."1.46Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine. ( Coca, M; Gomar, C; Masgoret, P; Ríos, J; Taurá, P; Tena, B, 2017)
"We studied sensitivity of mechanical hyperalgesia induced by a single intrathecal (i."1.46Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study. ( Constandil, L; Galleguillos, D; Hernández, A; Marcos, JL; Pelissier, T; Velásquez, L; Villanueva, L, 2017)
"Ketamine had less mechanical hyperalgesia in 6 h (p = 0."1.43A comparison of intrathecal magnesium and ketamine in attenuating remifentanil-induced hyperalgesia in rats. ( Ansong, E; Dong, J; Feng, X; Lin, H; Sun, J; Xu, X, 2016)
"Opioid-induced hyperalgesia was associated with an increase in the MAC in normal rats who had not undergone surgery."1.42Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Segura, IA, 2015)
"In morphine-only infusion rats, hyperalgesia and opioid insensitivity were both increased."1.42Long-Term Antihyperalgesic and Opioid-Sparing Effects of 5-Day Ketamine and Morphine Infusion ("Burst Ketamine") in Diabetic Neuropathic Rats. ( Broadbear, JH; Goodchild, CS; Kolosov, A; Mak, P, 2015)
"Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P < 0."1.42Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. ( Cheung, CW; Choi, SW; Irwin, M; Liman, S; Ng, KF; Qiu, Q; Tai, W; Wong, KL, 2015)
"Tramadol-induced hyperalgesia in the rat lasted for several weeks and was associated with an increase in the MAC of sevoflurane."1.42Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Gómez de Segura, IA, 2015)
"Ketamine was then tested as a potential therapeutic drug."1.39Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine. ( Beaudry, F; Castel, A; Hélie, P; Vachon, P, 2013)
"co-treatment with ketamine and pregabalin at sub-effect low doses may be a useful therapeutic method for the treatment of neuropathic pain patients."1.39Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice. ( Choi, JG; Jeon, BH; Kim, HW; Kim, JM; Ko, YK; Lee, JH; Lim, HS; Park, JB; Shin, YS, 2013)
"The patient also developed hyperalgesia, allodynia, and photophobia and became extremely irritable upon handling."1.38Suspected opioid-induced hyperalgesia in an infant. ( Chalkiadis, GA; Hallett, BR, 2012)
"Buprenorphine has a better analgesia/toxicity profile (a ceiling effect for respiratory depression, less potential for abuse) compared to typical mu-opioids."1.37Buprenorphine-induced hyperalgesia in the rat. ( Holtman, JR; Wala, EP, 2011)
"Diazepam effects were blocked by flumazenil."1.37Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011)
"Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg."1.37The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011)
"In prestressed rats, fULD-induced hyperalgesia and the exaggerated inflammatory hyperalgesia were prevented NMDA receptor antagonists."1.37Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process. ( Chateauraynaud, J; Gavello-Baudy, S; Laboureyras, E; Laulin, JP; Le Roy, C; Simonnet, G, 2011)
"Ketamine is an important analgesia clinically used for both acute and chronic pain."1.37Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain. ( Hayashi, Y; Inoue, K; Kawaji, K; Kohsaka, S; Koyano, K; Nakanishi, H; Sun, L; Yokoyama, T; Zhang, X, 2011)
"Morphine was more effective in ketamine-treated (1 and 50 mg kg(-1)) mice."1.36Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine. ( Fourcade, O; Girolami, JP; Minville, V; Tack, I, 2010)
"heat allodynia) followed by a persistent area of secondary tactile allodynia."1.36Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010)
"Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor."1.36The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. ( Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS, 2010)
"It had less effect on tactile allodynia (CCI)."1.35Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008)
"The induction of chest wall somatic allodynia was accompanied by a reduction in the latency of the P1 (36 +/- 3 ms to 30 +/- 4 ms p = 0."1.34Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification - evidence of central sensitization. ( Aziz, Q; Delaney, C; Hobson, AR; Kelly, K; Sharma, A; Willert, RP, 2007)
"In children with advanced stages of cancer, pain control remains inadequate in many patients and a solution to this problem is sorely lacking."1.34Ketamine as an adjuvant for treatment of cancer pain in children and adolescents. ( Finkel, JC; Pestieau, SR; Quezado, ZM, 2007)
"Inflammation was induced with a unilateral subcutaneous injection of Car in a plantar hindpaw in rats fed without (control group) or with (deficiency group) a polyamine-deficient diet."1.33An evaluation of a polyamine-deficient diet for the treatment of inflammatory pain. ( Ecoffey, C; Estebe, JP; Gentili, M; Leduc, C; Legay, F; Moulinoux, JP; Wodey, E, 2006)
"Opioid-induced hyperalgesia has been demonstrated in awake animals."1.32Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia. ( Boulanger, V; Collet, V; De Kock, M; Docquier, MA; Lavand'homme, P, 2004)
"The initial hyperalgesia induced by 0."1.31Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002)
"Ketamine pretreatment, which had no analgesic effect on its own, enhanced the earlier response (analgesia) and prevented the development of long-lasting hyperalgesia."1.31Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. ( Célèrier, E; Jun, Y; Larcher, A; Laulin, JP; Reynier, P; Rivat, C; Simonnet, G, 2000)
"ketamine was effective only when given as a pretreatment."1.31Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model. ( Lee, IH; Lee, IO, 2001)
"Ketamine pretreatment (10 mg/kg) increased the fentanyl analgesic effect (4 x 60 microg/kg), suppressed the immediate hyperalgesic phase, and restored the full effect of a subsequent morphine injection."1.31The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. ( Chauvin, M; Corcuff, JB; Laulin, JP; Maurette, P; Rivat, C; Simonnet, G, 2002)
" The results demonstrate that the behavioral hyperalgesia associated with carrageenan-induced hindpaw inflammation in rats is attenuated by the intrathecal administration of racemic and S(+)-ketamine, but not R(-)-ketamine, which only displayed an insignificant trend toward a dose-response relationship."1.30Antinociceptive effect of the S(+)-enantiomer of ketamine on carrageenan hyperalgesia after intrathecal administration in rats. ( Benedek, G; Dobos, I; Horváth, G; Klimscha, W; Szikszay, M, 1998)
"The onset of resultant hyperalgesia was evaluated using von Frey monofilaments."1.30Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat. ( Hartrick, CT; Patterson, JS; Wise, JJ, 1998)
"The CCI rats showed hyperalgesia to thermal and mechanical pressure stimuli on the injured side of their hind paws."1.30[Suppressive effects of ketamine on neuropathic pain]. ( Omote, K; Sonoda, H, 1998)
"Thus, transgenic mice exhibited mechanical allodynia."1.30Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists. ( Cuello, AC; Henry, JL; Julien, JP; McLeod, AL; Ribeiro-Da-Silva, A; Ritchie, J, 1999)
"Moreover, the absence of mechanical hyperalgesia raises the possibility that central changes in noxious information processing may not be detected using mechanical stimuli in the same time course as thermal stimuli."1.29The effect of abdominal surgery on thresholds to thermal and mechanical stimulation in sheep. ( Nolan, AM; Welsh, EM, 1995)

Research

Studies (151)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's24 (15.89)18.2507
2000's58 (38.41)29.6817
2010's56 (37.09)24.3611
2020's13 (8.61)2.80

Authors

AuthorsStudies
Meyer-Frießem, CH1
Lipke, E1
Weibel, S1
Kranke, P1
Reichl, S1
Pogatzki-Zahn, EM1
Zahn, PK1
Schnabel, A1
Hino, C1
Ran-Castillo, D1
Akhtari, M1
Cao, H1
Silvestre, J1
Kim, NA1
Kim, BG1
Lee, J1
Chung, HT1
Kwon, HR1
Kim, YS1
Choi, JB1
Song, JH1
Hirota, K1
Lambert, DG1
Efune, PN1
Rebstock, SE1
McDonald, WM1
Wilkinson, MM1
Jain, A1
Cohen, SP1
Zhou, X1
Li, Q1
Luo, Q1
Wang, L2
Chen, J1
Xiong, Y1
Wu, G1
Chang, L1
Liu, P1
Shu, H1
Qi, F1
Liu, T1
Zhang, X2
Gao, X1
Li, Z1
Chen, L2
Lin, C1
Wang, ZJ1
Tang, H1
Chen, Z1
Banki, L1
Büki, A1
Horvath, G3
Kekesi, G1
Kis, G1
Somogyvári, F1
Jancsó, G1
Vécsei, L1
Varga, E1
Tuboly, G2
Coutens, B1
Derreumaux, C1
Labaste, F1
Minville, V2
Guiard, BP1
Moulédous, L1
Bounes, V1
Roussin, A1
Frances, B1
Viisanen, H1
Lilius, TO1
Sagalajev, B1
Rauhala, P1
Kalso, E1
Pertovaara, A1
Velzen, MV1
Dahan, JDC1
van Dorp, ELA1
Mogil, JS1
Hooijmans, CR1
Dahan, A4
Kopsky, DJ1
Keppel Hesselink, JM1
Masgoret, P1
Gomar, C2
Tena, B2
Taurá, P1
Ríos, J2
Coca, M1
Marcos, JL1
Galleguillos, D1
Pelissier, T2
Hernández, A2
Velásquez, L1
Villanueva, L1
Constandil, L1
Moon, YE1
Kim, MH1
Lee, HM1
Yoon, HM1
Jeon, YJ1
Cornelissen, JC1
Steele, FF1
Rice, KC1
Nicholson, KL1
Banks, ML1
Porter, SB1
Schwenk, ES1
Pan, W2
Zhang, GF2
Li, HH1
Ji, MH1
Zhou, ZQ1
Li, KY1
Yang, JJ2
Breivik, H2
Brinck, EC1
Tiippana, E1
Heesen, M1
Bell, RF1
Straube, S1
Moore, RA1
Kontinen, V1
Hayhurst, CJ1
Farrin, E1
Hughes, CG1
Barelli, R1
Morelli Sbarra, G1
Sbaraglia, F1
Zappia, L1
Rossi, M1
Thompson, T1
Whiter, F1
Gallop, K1
Veronese, N1
Solmi, M1
Newton, P1
Stubbs, B1
Wang, J4
Zhao, Q1
Zhou, Y2
Sun, W1
Han, S1
Peng, Y1
Li, J1
Han, R1
Willeford, A1
Atayee, RS1
Winters, KD1
Mesarwi, P1
Castel, A1
Hélie, P1
Beaudry, F1
Vachon, P1
Ohnesorge, H1
Feng, Z1
Zitta, K1
Steinfath, M1
Albrecht, M1
Bein, B1
Jabbour, HJ1
Naccache, NM1
Jawish, RJ1
Abou Zeid, HA1
Jabbour, KB1
Rabbaa-Khabbaz, LG1
Ghanem, IB1
Yazbeck, PH1
Pestieau, SR2
Finkel, JC2
Junqueira, MM1
Cheng, Y1
Lovejoy, JF1
Quezado, Z1
M'Dahoma, S1
Bourgoin, S1
Kayser, V1
Barthélémy, S1
Chevarin, C1
Chali, F1
Orsal, D1
Hamon, M1
Birklein, F1
O'Neill, D1
Schlereth, T1
Abreu, M2
Aguado, D2
Benito, J2
García-Fernández, J2
Segura, IA1
Juel, J1
Olesen, SS1
Olesen, AE1
Poulsen, JL1
Wilder-Smith, O1
Madzak, A1
Frøkjær, JB1
Drewes, AM1
Mak, P1
Broadbear, JH1
Kolosov, A1
Goodchild, CS1
Zhang, C1
Li, SS1
Zhao, N1
Yu, C2
Leal, PC1
Salomão, R1
Brunialti, MK1
Sakata, RK1
Liman, S1
Cheung, CW1
Wong, KL1
Tai, W1
Qiu, Q1
Ng, KF1
Choi, SW1
Irwin, M1
Nickel, FT1
Ott, S1
Möhringer, S1
Münster, T1
Rieß, S1
Filitz, J1
Koppert, W6
Maihöfner, C1
Gómez de Segura, IA1
Martinez, V1
Derivaux, B1
Beloeil, H1
Bornemann-Cimenti, H1
Wejbora, M1
Michaeli, K1
Edler, A1
Sandner-Kiesling, A1
Han, JF1
Guo, J1
Xie, ZM1
Sun, KJ1
Sun, J1
Lin, H1
Feng, X1
Dong, J1
Ansong, E1
Xu, X1
Holtman, JR3
Crooks, PA1
Johnson-Hardy, JK1
Hojomat, M1
Kleven, M1
Wala, EP3
Benedek, G2
Mion, G1
Libert, N1
Cirodde, A1
Tourtier, JP1
Rousseau, JM1
Ben-David, B1
Chelly, JE1
Garrido-Suárez, BB1
Garrido, G1
Márquez, L1
Martínez, I1
Hernández, I1
Merino, N1
Luque, Y1
Delgado, R1
Bosch, F1
Kitamura, T1
Imai, Y1
Ohno, N1
Muroya, M1
Ogawa, M1
Yamada, Y1
Sigtermans, M1
Mooren, R1
Bauer, M1
Kest, B1
Sarton, E1
Olofsen, E1
Boettger, MK1
Weber, K1
Gajda, M1
Bräuer, R1
Schaible, HG1
Fourcade, O1
Girolami, JP1
Tack, I1
Gu, X1
Wu, X1
Liu, Y1
Cui, S1
Ma, Z1
Marchant, N1
Joris, J1
Modir, JG1
Wallace, MS3
Griffiths, R1
Mei, XP3
Wang, W6
Zhu, C1
Zhang, T1
Xu, LX3
Wu, SX1
Li, YQ3
Rondon, ES1
Vieira, AS1
Valadão, CA1
Parada, CA1
Zhang, H2
Wei, YY1
Zhai, MZ1
Tang, J1
Hang, LH1
Shao, DH1
Gu, YP1
Swartjes, M1
Morariu, A1
Niesters, M1
Aarts, L1
Quintero, L1
Cardenas, R1
Suarez-Roca, H1
Van Elstraete, AC2
Sitbon, P2
Benhamou, D2
Mazoit, JX2
Forero, M1
Chan, PS1
Restrepo-Garces, CE1
Le Roy, C1
Laboureyras, E1
Gavello-Baudy, S1
Chateauraynaud, J1
Laulin, JP3
Simonnet, G3
Romero, TR1
Galdino, GS1
Silva, GC1
Resende, LC1
Perez, AC1
Côrtes, SF1
Duarte, ID1
Goffer, Y1
Xu, D1
Tukey, DS1
Shamir, DB1
Eberle, SE1
Zou, AH1
Blanck, TJ1
Ziff, EB1
Hallett, BR1
Chalkiadis, GA1
Hayashi, Y1
Kawaji, K1
Sun, L1
Koyano, K1
Yokoyama, T1
Kohsaka, S1
Inoue, K1
Nakanishi, H1
Mamie, C1
Yalcin, N1
Uzun, ST1
Reisli, R1
Borazan, H1
Otelcioglu, S1
Slater, H1
Graven-Nielsen, T2
Wright, A1
Schug, SA1
Lim, HS1
Kim, JM1
Choi, JG1
Ko, YK1
Shin, YS1
Jeon, BH1
Park, JB1
Lee, JH1
Kim, HW1
Colpaert, FC1
Tarayre, JP1
Koek, W1
Pauwels, PJ1
Bardin, L1
Xu, XJ1
Wiesenfeld-Hallin, Z1
Cosi, C1
Carilla-Durand, E1
Assié, MB1
Vacher, B1
Jørum, E4
Warncke, T4
Stubhaug, A6
Luginbühl, M1
Gerber, A1
Schnider, TW1
Petersen-Felix, S1
Arendt-Nielsen, L7
Curatolo, M1
Oatway, M1
Reid, A1
Sawynok, J1
Sittl, R4
Scheuber, K1
Alsheimer, M1
Schmelz, M5
Schüttler, J3
Alvarez, P1
Angst, MS1
Pahl, I1
Clark, DJ1
Willert, RP2
Woolf, CJ1
Hobson, AR2
Delaney, C2
Thompson, DG1
Aziz, Q2
Gottrup, H3
Bach, FW2
Jensen, TS6
Raeder, J1
Chaaben, K1
Marret, E1
Lamonerie, L1
Lembert, N1
Bonnet, F1
Docquier, MA1
Lavand'homme, P3
Boulanger, V1
Collet, V1
De Kock, M4
Ozyalcin, NS1
Yucel, A1
Camlica, H1
Dereli, N1
Andersen, OK2
Joly, V1
Richebe, P1
Guignard, B1
Fletcher, D1
Maurette, P2
Sessler, DI1
Chauvin, M2
Brennan, TJ1
Kehlet, H1
Waterloos, H2
Luo, YL1
Xiao, SS1
Li, Y1
Zhang, Q1
Trabold, F1
Pöyhiä, R1
Vainio, A1
Petrenko, AB1
Yamakura, T1
Askalany, AR1
Kohno, T1
Sakimura, K1
Baba, H1
Estebe, JP1
Legay, F1
Gentili, M1
Wodey, E1
Leduc, C1
Ecoffey, C1
Moulinoux, JP1
Guntz, E1
Talla, G1
Roman, A1
Dumont, H1
Segers, B1
Sosnowski, M1
Tröster, A1
Singler, B1
Klein, T1
Magerl, W1
Nickel, U1
Hopf, HC1
Sandkühler, J1
Treede, RD1
Baad-Hansen, L1
Juhl, GI1
Brandsborg, B1
Svensson, P1
Kelly, K1
Sharma, A1
Quezado, ZM1
De Kock, MF1
Lavand'homme, PM1
Reuben, SS1
Buvanendran, A1
Kern, D1
Pelle-Lancien, E1
Luce, V1
Bouhassira, D1
Guedj, E1
Cammilleri, S1
Colavolpe, C1
de Laforte, C1
Niboyet, J1
Mundler, O1
Haugan, F1
Rygh, LJ1
Tjølsen, A1
Lois, F1
Welsh, EM1
Nolan, AM1
Ghorpade, A1
Advokat, C1
Backonja, M1
Arndt, G1
Gombar, KA1
Check, B1
Zimmermann, M1
Tverskoy, M1
Oz, Y1
Isakson, A1
Finger, J1
Bradley, EL2
Kissin, I2
Park, KM1
Max, MB2
Robinovitz, E1
Gracely, RH1
Bennett, GJ2
Ilkjaer, S2
Petersen, KL1
Brennum, J2
Wernberg, M1
Dahl, JB2
Qian, J1
Brown, SD1
Carlton, SM1
Felsby, S2
Nielsen, J1
Nicolaisen, L1
Bjerring, P1
Chaplan, SR1
Malmberg, AB1
Yaksh, TL2
Walker, SM1
Cousins, MJ1
Eide, PK1
Kreunen, M1
Foss, A1
Klimscha, W1
Szikszay, M1
Dobos, I1
Hartrick, CT1
Wise, JJ1
Patterson, JS1
Sonoda, H2
Omote, K2
Sethna, NF1
Liu, M1
Gracely, R1
McLeod, AL1
Ritchie, J1
Cuello, AC1
Julien, JP1
Ribeiro-Da-Silva, A1
Henry, JL1
Mikkelsen, S1
Borgbjerg, FM1
Zeck, S1
Blunk, JA1
Likar, R1
Mitchell, AC1
Célèrier, E1
Rivat, C2
Jun, Y1
Larcher, A1
Reynier, P1
Hansen, PO1
Kendall, SA1
Henriksson, KG1
Bengtsson, M1
Sörensen, J1
Johnson, A1
Gerdle, B1
Kawamata, T1
Kawamata, M1
Namiki, A1
Bright, CA1
Leung, A2
Ridgeway, B2
Yaksh, T1
Vick, PG1
Lamer, TJ1
Dern, SK1
Albrecht, S1
Lee, IO1
Lee, IH1
Schulteis, G1
Klepstad, P1
Borchgrevink, P1
Hval, B1
Flaat, S1
Kaasa, S1
Corcuff, JB1
Ren, K1
Williams, GM1
Hylden, JL1
Ruda, MA1
Dubner, R1

Clinical Trials (49)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
(2R,6R)-Hydroxynorketamine a Novel Therapeutic Analgesic for the Treatment of Neuropathic Pain: A Randomized Double Blind Cross-Over Trial.[NCT05864053]Phase 1/Phase 225 participants (Anticipated)Interventional2024-01-31Not yet recruiting
The Effect of Low-dose of S-ketamine Combined With Sufentanil for Postoperative Patient-controlled Intravenous Analgesia in Patients Following Cesarean Section[NCT05299866]Phase 4216 participants (Anticipated)Interventional2022-04-12Recruiting
Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial[NCT04964219]Phase 4164 participants (Anticipated)Interventional2022-02-08Recruiting
Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial[NCT04791059]Phase 4200 participants (Actual)Interventional2021-04-09Completed
Observational Study of the Efficacy of Ketamine for Rescue Analgesia in the Post Anesthesia Recovery Room[NCT04701008]143 participants (Actual)Observational2020-09-01Completed
The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283]Phase 41,544 participants (Anticipated)Interventional2021-04-12Enrolling by invitation
Is The Pre-Emptive Administration Of Ketamine A Significant Adjunction To Intravenous Morphine Analgesia For Controlling Post-Operative Pain? A Randomized, Double Blind, Placebo Controlled Clinical Trial.[NCT03415191]75 participants (Actual)Interventional2012-01-05Completed
The Comparison of Analgesia Methods Used for Spinal Surgery[NCT04603638]82 participants (Anticipated)Interventional2020-03-04Recruiting
The Effect of a Regimen of Opioid Sparing Anesthesia on Postoperative Recovery[NCT05594407]60 participants (Anticipated)Interventional2022-08-01Recruiting
Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents[NCT01325493]Phase 454 participants (Actual)Interventional2010-01-31Completed
Pilot Study on the Assessment of Motor Imaging Skills in Patients With Complex Regional Pain Syndrome (CRPS)[NCT04703348]129 participants (Actual)Interventional2021-01-12Completed
Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals[NCT05473338]250 participants (Anticipated)Observational2022-04-14Active, not recruiting
A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation[NCT06096181]Phase 2120 participants (Anticipated)Interventional2023-12-31Not yet recruiting
Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024]Phase 4174 participants (Anticipated)Interventional2023-12-31Not yet recruiting
Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial[NCT05950646]Phase 4154 participants (Anticipated)Interventional2023-11-01Recruiting
Dexmedetomidine-esketamine Combined With Oxycodone for Ultrasound-guided Percutaneous Radiofrequency Ablation in Patients With Liver Cancer: a Randomized Controlled Study[NCT06003218]88 participants (Anticipated)Interventional2023-10-16Recruiting
Efficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind Trial[NCT06062550]Phase 4312 participants (Anticipated)Interventional2023-10-31Not yet recruiting
Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial[NCT06087510]Phase 4312 participants (Anticipated)Interventional2024-01-31Not yet recruiting
Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial[NCT05732064]Phase 4180 participants (Anticipated)Interventional2023-05-22Recruiting
A Randomized Controlled Trial to Determine the Efficacy of Ketamine as an Adjunct for Pain Management in Patients With Sickle Cell Crisis[NCT03502421]Phase 30 participants (Actual)Interventional2018-09-01Withdrawn (stopped due to Never IRB approved, no intention to proceed with the study)
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702]Phase 124 participants (Anticipated)Interventional2023-03-17Recruiting
Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia[NCT03066739]Phase 2105 participants (Anticipated)Interventional2023-02-25Recruiting
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease, a Pilot Study[NCT02801292]Phase 320 participants (Anticipated)Interventional2016-07-31Not yet recruiting
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia Using Filaments, an Algometer, and Interleukins: a Double-blind, Randomized Study[NCT01301079]Phase 360 participants (Actual)Interventional2010-09-30Completed
Can Opioid-induced Hyperalgesia be Prevented by Gradual Dose Reduction vs. Abrupt Withdrawal of Remifentanil?[NCT01702389]Phase 416 participants (Actual)Interventional2012-10-31Completed
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461]137 participants (Actual)Observational2009-07-31Completed
Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis[NCT02571491]Phase 248 participants (Actual)Interventional2012-01-31Completed
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938]Phase 450 participants (Actual)Interventional2016-12-31Completed
Influence of Intraoperative Analgesia (Sufentanil Administered According to the Usual Criteria or Remifentanil Administered by a Closed-loop System Using Bispectral Index as the Controller) on the Postoperative Morphine Consumption[NCT00772616]Phase 460 participants (Actual)Interventional2008-09-30Completed
Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial[NCT02421913]Phase 442 participants (Actual)Interventional2012-06-30Completed
Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery[NCT02416752]222 participants (Actual)Observational2011-08-31Completed
Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001]Phase 460 participants (Actual)Interventional2015-01-31Completed
Transversus Abdominis Plane (TAP) Block for Cesarean Section[NCT01015807]90 participants (Actual)Interventional2009-11-30Completed
Pre-Emptive Analgesia in Ano-Rectal Surgery[NCT02402543]90 participants (Actual)Interventional2014-06-30Completed
Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904]15 participants (Anticipated)Observational2011-06-30Recruiting
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091]Phase 210 participants (Actual)Interventional2009-02-28Completed
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)[NCT02422290]Phase 1/Phase 25 participants (Actual)Interventional2015-03-31Completed
Phase 4 Study of Prevention of Persistent Postsurgical Pain After Thoracotomy Using Ketamine[NCT01243801]Phase 4104 participants (Actual)Interventional2008-09-30Completed
Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726]150 participants (Anticipated)Interventional2015-09-30Not yet recruiting
Ketamine Tolerance in Children After Repeated Administrations During Radiotherapy Sessions[NCT02512055]Phase 433 participants (Actual)Interventional2012-05-31Completed
Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325]Phase 324 participants (Actual)Interventional2011-07-31Completed
Effects of Perioperative Systemic Ketamine on Development of Long-term Neuropathic Pain After Thoracotomy.[NCT00313378]Phase 378 participants (Actual)Interventional2004-04-30Completed
The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients.[NCT00163969]Phase 440 participants Interventional2002-04-30Completed
Nitrous Oxide as Treatment for Fibromyalgia[NCT05357066]Phase 250 participants (Anticipated)Interventional2021-11-12Recruiting
Efficacy of Memantine in the Treatment of Fibromyalgia: a Double-blind Randomized Trial[NCT01653457]Phase 360 participants (Anticipated)Interventional2012-09-30Not yet recruiting
The Effects of Subanesthetic Ketamine on Respiratory Stimulation and Transpulmonary Pressures in Mechanically Ventilated Critically Ill Patients[NCT01969227]15 participants (Actual)Interventional2014-01-31Completed
Effects of Low Doses of Ketamine on Postoperative Quality of Recovery After Total Intravenous Anesthesia[NCT02571153]Phase 4135 participants (Actual)Interventional2015-09-30Completed
Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department[NCT02489630]Phase 4116 participants (Actual)Interventional2013-09-30Completed
Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia[NCT00373893]Phase 112 participants Interventional2005-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Morphine Equivalent Consumption (mg/kg)

Morphine consumption (mg/kg) was measured over time in the Ketamine group and compared to the Control (saline) group. Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: at 24, 48, 72, 96 hours post operatively

,
Interventionmg/kg (Mean)
24 hrs after surgery48 hrs after surgery72 hrs after surgery96 hrs after surgery
Ketamine1.31.28.89.57
Saline1.361.275.93.38

Pain Score at Rest

Patient volunteered response at rest, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively

,
Interventionpain score at rest (Mean)
24 hrs after surgery48 hrs after surgery72 hrs after surgery96 hrs after surgery
Ketamine3.94.533.64.48
Saline4.555.23.483.8

Pain Score During Cough.

Patient volunteered response during a cough, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively

,
Interventionpain score at cough (Mean)
24 hrs after surgery48 hrs after surgery72 hrs after surgery96 hrs after surgery
Ketamine4.55.44.45.15
Saline5.15.453.74.2

Sedation Score

"Sedation scores 0 = completely awake~= sleepy but responds appropriately~= somnolent but arouses to light stimuli~= asleep but responsive to deeper physical stimuli~= asleep and not responsive to any stimuli Values are for each 24 hour time period and displayed as hours post surgery." (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively

,
InterventionSedation Score (Mean)
24 hrs after surgery48 hrs after surgery72 hrs after surgery96 hrs after surgery
Ketamine.73.62.38.24
Saline.75.54.3.21

Allodynia as Detected With a Soft Brush in the Periumbilical Region 24 h After the Procedure

The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure

Interventionparticipants (Number)
Ketamine1
Saline0

Allodynia as Detected With a Soft Brush in the Periumbilical Region Before the Procedure

The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventionparticipants (Number)
Ketamine1
Saline0

Allodynia as Detected With a Soft Brush in the Thenar Eminence 24 h After the Procedure

The evaluations using the soft brush were performed in the thenar eminence of the non dominant hand 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure

Interventionparticipants (Number)
Ketamine1
Saline3

Allodynia as Detected With a Soft Brush in the Thenar Eminence Before the Procedure

The evaluations using the soft brush were performed in the thenar eminence of the nondominant hand before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventionparticipants (Number)
Ketamine1
Saline0

Extension of Hyperalgesia

The 300-g filament was used 24 hours after the operation to induce a stimulus and delineate the extent of hyperalgesia from the periumbilical region. The stimulus was started outside the periumbilical region, where no pain sensation was reported, and continued every 0.5 cm until the 4 points of the periumbilical scar were reached (top, right side, left side, and bottom). The first point where the patient complained of pain was marked. If no pain sensation was reported, the stimulus was terminated 0.5 cm from the incision. The distance of each point from the surgical incision was measured, and the sum of the distances of the points was determined. (NCT01301079)
Timeframe: 24 hours after the procedure

Interventioncentimeter (Mean)
Ketamine10.61
Saline11.82

Hyperalgesia in the Postoperative Period as Measured With Algometer in the Periumbilical Region

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionkilogram force/second (Mean)
Ketamine3.5
Saline3.7

Hyperalgesia in the Postoperative Period as Measured With Algometer in Thenar Eminence

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionkilogram force/second (Mean)
Ketamine0.56
Saline0.51

Hyperalgesia in the Postoperative Period as Measured With Monofilaments in the Periumbilical Region

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the postoperative period (24h after the procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24h after the procedure

Interventiongram (Mean)
Ketamine248
Saline205

Hyperalgesia in the Postoperative Period as Measured With Monofilaments in Thenar Eminence

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the postoperative period (24 hours after procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24 hours after procedure

Interventiongram (Mean)
Ketamine290
Saline247

Hyperalgesia in the Preoperative Period as Measured With Algometer in the Periumbilical Region

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the surgery)

Interventionkilogram force/second (Mean)
Ketamine3.6
Saline3.9

Hyperalgesia in the Preoperative Period as Measured With Algometer in Thenar Eminence

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the procedure)

Interventionkilogram force/second (Mean)
Ketamine2.51
Saline2.19

Hyperalgesia in the Preoperative Period as Measured With Monofilaments in the Periumbilical Region

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventiongram (Mean)
Ketamine279
Saline269

Hyperalgesia in the Preoperative Period as Measured With Monofilaments in Thenar Eminence

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventiongram (Mean)
Ketamine300
Saline300

Morphine Consumption Within 24 h

(NCT01301079)
Timeframe: 24 hours

Interventionmilligram (Mean)
Ketamine27.40
Saline27.70

Pain 12 Hours

The scale measure pain after 12 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 12 hours

Interventionunits on a scale (Mean)
Ketamine1.6
Saline1.4

Pain 120 Minutes

The scale measure pain after 120 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 120 minutes

Interventionunits on a scale (Mean)
Ketamine2.2
Saline2.0

Pain 150 Minutes

The scale measure pain after 150 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 150 minutes

Interventionunits on a scale (Mean)
Ketamine1.4
Saline1.4

Pain 18 Hours

The scale measure pain after 18 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 18 hours

Interventionunits on a scale (Mean)
Ketamine1.5
Saline1.3

Pain 180 Minutes

The scale measure pain after 180 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 180 minutes

Interventionunits on a scale (Mean)
Ketamine1.1
Saline1.3

Pain 210 Minutes

The scale measure pain after 210 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 210 minutes

Interventionunits on a scale (Mean)
Ketamine0.9
Saline1.2

Pain 24 Hours

The scale measure pain after 24 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 24 hours

Interventionunits on a scale (Mean)
Ketamine1.4
Saline0.8

Pain 240 Minutes

The scale measure pain after 240 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 240 minutes

Interventionunits on a scale (Mean)
Ketamine1.0
Saline1.1

Pain 30 Minutes

The scale measure pain after 30 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 30 minutes

Interventionunits on a scale (Mean)
Ketamine5.5
Saline6.2

Pain 6 Hours

The scale measure pain after 6 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 6 hours

Interventionunits on a scale (Mean)
Ketamine0.9
Saline0.7

Pain 60 Minutes

The scale measure pain after 60 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 60 minutes

Interventionunits on a scale (Mean)
Ketamine4.6
Saline5.1

Pain 90 Minutes

The scale measure pain after 90 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 90 minutes

Interventionunits on a scale (Mean)
Ketamine3.4
Saline3.4

Serum Level of Interleukin (IL)-10 24 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine8.6
Saline5.0

Serum Level of Interleukin (IL)-10 5h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-10 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine9.1
Saline5.5

Serum Level of Interleukin (IL)-10 Before the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)

Interventionpicogram/milliliter (Mean)
Ketamine7.8
Saline1.9

Serum Level of Interleukin (IL)-6 24 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine24.1
Saline24.8

Serum Level of Interleukin (IL)-6 5 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine29.3
Saline34.8

Serum Level of Interleukin (IL)-6 Before the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)

Interventionpicogram/milliliter (Mean)
Ketamine3.3
Saline2.1

Serum Level of Interleukin (IL)-8 24 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine6.0
Saline4.5

Serum Level of Interleukin (IL)-8 5 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine8.0
Saline11.3

Serum Level of Interleukin (IL)-8 Before the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)

Interventionpicogram/milliliter (Mean)
Ketamine3.3
Saline2.2

Time to First Morphine Supplementation

(NCT01301079)
Timeframe: 24 hours

Interventionminutes (Median)
Ketamine18
Saline15

Wound Hyperalgesia Index (WHA) Assessed 48 Hrs After Block Placement in the Different Groups

Determine which of three different TAP formulations (Placebo, TAP, Clo-TAP) has the most beneficial effect on the postoperative area of hyperalgesia 48hrs after the start of the cesarean section. The smaller the area of WHA, assessed in cm2, the better the outcome. Area sizes may range from 0 to any size. (NCT01015807)
Timeframe: 48hrs after CS

Interventioncm^2 (Mean)
Placebo1.07
TAP (Bupi)1.27
Clo-TAP (Bupi + Clon)0.74

Objective Opioid Withdrawal Scale (OOWS)

OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)

,
Interventionunits on a scale (Mean)
Pretreatment30 min prior to REM infusion15 min after start of REM infusion40 min after start of REM infusion5 minutes after finish of REM infusion15 minutes after finish of REM infusion75 minutes after finish of REM infusion
Placebo1.11.10.80.51.82.11.6
Propranolol1.21.10.10.832.81.7

Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH).

A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion

,
Interventionpercentage of change (Number)
15 min post remifentanil infusion60 min post remifentanil infusion
Placebo-34141.5
Propranolol-28-19

Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS)

The CY-BOCS is a semi-structured measure of OCD severity with excellent inter-rater reliability, internal consistency, and test-retest reliability. It is validated in those starting at age 7 and used in studies up to age 20. The CYBOCS differs from the adult YBOCS only in its use of simpler language. The CY-BOCS consists of 10 items which are summed up to derive the total CY-BOCS score. The total score ranges from 0-40 with higher scores indicating greater severity of OCD symptoms. (NCT02422290)
Timeframe: Screening, Baseline, Day 7, Day 17, 3-Month; Baseline and Day 14 pre-specified to be reported

Interventionscore on a scale (Mean)
CY-BOCS BaselineCY-BOCS Day 14
Ketamine Treatment Group29.0026.20

Clinical Global Impressions - Severity Scale (CGI-S)

The CGI-S is a clinician rated 7-point rating scale for the severity of a participant's illness relative to the clinician's experience of working with this particular population. The score ranges from 1-7 with higher scores indicating greater illness severity. (NCT02422290)
Timeframe: Screening, Baseline, Day 7, Day 17, 3-Month; Baseline and Day 14 pre-specified to be reported

Interventionscore on a scale (Mean)
CGI-S BaselineCGI-S Day 14
Ketamine Treatment Group5.805.00

OCD Visual Analogue Scale (OCD-VAS)

"The OCD-VAS is a one-item unipolar scale to assess OCD symptoms over a rapid time frame (No obsessions to Constant obsessions). The scale ranges from 0-10 with higher scores indicating higher presence of obsessions." (NCT02422290)
Timeframe: Screening, Baseline, Day 1-14, 3-Month; Baseline and Day 14 pre-specified to be reported

Interventionscore on a scale (Mean)
OCD-VAS BaselineOCD-VAS Day 14
Ketamine Treatment Group5.005.00

Yale-Brown Obsessive Compulsive Challenge Scale (Y-BOCCS)

"The Y-BOCCS is self-report scale which assesses OCD symptoms on a 5-point likert scale (None to Extreme). It consists of 10 items which are summed up to derive the total Y-BOCCS score. The total score ranges from 0-40 with higher scores indicating higher prevalence of OCD symptoms." (NCT02422290)
Timeframe: Screening, Baseline, Day 1-14, 3-Month; Baseline and Day 14 pre-specified to be reported

Interventionscore on a scale (Mean)
Y-BOCCS BaselineY-BOCCS Day 14
Ketamine Treatment Group18.2516.50

Length of PACU Stay

Length of stay at postanesthesia recovery room (NCT02571153)
Timeframe: During the stay at postanesthesia recovery room (about 90 to 120 minutes)

Interventionminutes (Mean)
Saline Group82.9
Ketamine 0.284.5
Ketamine 0.486

Morphine Consumption (mg) at PACU

Morphine consumption (mg) at PACU (about 90 to 120 minutes) (NCT02571153)
Timeframe: During the stay at postanesthesia recovery room (about 90 to 120 minutes)

Interventionmg (Mean)
Saline Group1.6
Ketamine 0.20.9
Ketamine 0.41.1

Occurrence of Pain at PACU Using a 0-10 Numeric Pain Rating Scale

Occurrence of pain at the PACU. Average Pain will be calculated. The pain score will be evaluated using a 0-10 numeric pain rating scale, where zero mean no pain and 10 the worst imaginable pain. (NCT02571153)
Timeframe: 90 minutes postanesthesia at recovery room

Interventionunits on a scale (Mean)
Saline Group3.8
Ketamine 0.22.6
Ketamine 0.42.8

Occurrence of Postoperative, Nausea and Vomiting

Percentage of participants with postoperative nausea and vomiting at the PACU and during the hospital ward stay (NCT02571153)
Timeframe: 24 hours

Interventionpercentage of participants (Number)
Saline Group30.8
Ketamine 0.229.7
Ketamine 0.439.5

Percentage of Participants With Tramadol Consumption

Percentage of Participants with Tramadol during the ward stay (NCT02571153)
Timeframe: 24 hours

Interventionpercentage of participants (Number)
Saline Group5.1
Ketamine 0.210.8
Ketamine 0.413.9

Quality of Postoperative Recovery Assessed by QoR-40 Questionnaire 24 Hours After Surgery

Quality of postoperative functional recovery assessed by the questionnaire QoR40 The quality of postoperative functional recovery was assessed by the QoR-40 questionnaire, which assesses five dimensions of recovery (physical comfort - 12 items; emotional state - 7 items; physical independence - 5 items; physiological support - 7 items; and pain - 7 items). Each item was rated on a five-point Likert scale: none of the time, some of the time, usually, most of the time, and all the time. The total score on the QoR-40 ranges from 40 (poorest quality of recovery) to 200 (best quality of recovery). The QoR-40 was administered by a blind investigator 24 hours after surgery. (NCT02571153)
Timeframe: 24 hours

Interventionunits on a scale (Mean)
Saline Group187.8
Ketamine 0.2189.6
Ketamine 0.4186.8

The Severity of Postoperative Pain

"The severity of postoperative pain was rated the higher score of pain (NRS) during the hospital ward stay.~Pain was evaluated using a 0-10 numeric pain rating scale (NRS), where zero meant no pain and 10 the worst imaginable pain." (NCT02571153)
Timeframe: 24 hours

Interventionunits on a scale (Mean)
Saline Group3.2
Ketamine 0.22.8
Ketamine 0.43.6

Change in Level of Pain Control as Reported on the NRS-11

"Patient-reported pain scores on numerical rating scale (NRS) -11 pain scale (where 0 indicates no pain at all, 10 indicates the most severe pain). Initial group were patients enrolled and randomized in to the study, assessments were taken at the time of enrollment/randomization in to the study (up to 20 min prior to T=0). T = 0 min assessments were conducted at the time of medication administration (study allowed for an up to 20-minute delay in receiving study drug in order to retrieve study drug from secure storage, nursing documentation and patient verification prior to administration)." (NCT02489630)
Timeframe: 20 min pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration

,
InterventionUnits on a scale (1-10) (Mean)
InitialT = 0 minT = 30 minT = 60 minT = 90 minT = 120 min
Ketamine9.387.515.255.314.514.24
Placebo9.448.102.276.186.215.68

Change in Patient Satisfaction With Pain Control on a 1-4 Likert Scale

Patient-reported score regarding satisfaction with pain control, reported on a 4-point Likert scale (1-4, where 1 is the lowest satisfaction score possible and 4 is the highest satisfaction score possible). No data is reported for T = 0 min, as that assessment was conducted concurrently with initial medication dosing (since patients were at that point receiving their first pain control efforts, they could not yet assess their satisfaction with those efforts). (NCT02489630)
Timeframe: 0 min, 30 min, 60 min, 90 min, 120 min post medication administration

,
InterventionUnits on a scale (1-4) (Mean)
T = 30 minT = 60 minT = 90 minT = 120 min
Ketamine2.092.382.542.66
Placebo2.272.332.382.52

Difference in Opiate Dosage Between Study Arms in Morphine Equivalents

"Average difference in opiate dosage between study arms, calculated in morphine equivalents. Initial indicates at first dose of opioid administration, up to 20 mins prior to study drug administration, and from 0 min to 120 min after study drug administration." (NCT02489630)
Timeframe: 20 mins pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration

,
InterventionMilligrams of Morphine Equivalent (Mean)
Initial Narcotic DosageTotal Narcotic Dosage
Ketamine5.419.95
Placebo5.8312.81

Reviews

12 reviews available for ketamine and Allodynia

ArticleYear
Perioperative ketamine for postoperative pain management in patients with preoperative opioid intake: A systematic review and meta-analysis.
    Journal of clinical anesthesia, 2022, Volume: 78

    Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Hyperalgesia; Ketamine; Pain, Postoperative

2022
Ketamine; history and role in anesthetic pharmacology.
    Neuropharmacology, 2022, 09-15, Volume: 216

    Topics: Analgesics, Opioid; Anesthetics; Humans; Hyperalgesia; Ketamine; Phencyclidine; Remifentanil

2022
Efficacy of ketamine in relieving neuropathic pain: a systematic review and meta-analysis of animal studies.
    Pain, 2021, 09-01, Volume: 162, Issue:9

    Topics: Animals; Hyperalgesia; Ketamine; Mice; Neuralgia; Rats

2021
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
Perioperative intravenous ketamine for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg

2018
NMDA receptor antagonists and pain relief: A meta-analysis of experimental trials.
    Neurology, 2019, 04-02, Volume: 92, Issue:14

    Topics: Acute Pain; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Mod

2019
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
[Ketamine revisited].
    Revue medicale de Liege, 2010, Volume: 65, Issue:1

    Topics: Analgesics; Humans; Hyperalgesia; Ketamine; Pain, Postoperative

2010
[Prevention of postoperative hyperalgesia].
    Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:1

    Topics: Amantadine; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Excit

2012
Ketamine, revival of a versatile intravenous anaesthetic.
    Advances in experimental medicine and biology, 2003, Volume: 523

    Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; H

2003
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
    Best practice & research. Clinical anaesthesiology, 2007, Volume: 21, Issue:1

    Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati

2007
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
    Best practice & research. Clinical anaesthesiology, 2007, Volume: 21, Issue:1

    Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati

2007
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
    Best practice & research. Clinical anaesthesiology, 2007, Volume: 21, Issue:1

    Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati

2007
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
    Best practice & research. Clinical anaesthesiology, 2007, Volume: 21, Issue:1

    Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati

2007
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
    The Journal of bone and joint surgery. American volume, 2007, Volume: 89, Issue:6

    Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima

2007
Something new about ketamine for pediatric anesthesia?
    Current opinion in anaesthesiology, 2008, Volume: 21, Issue:3

    Topics: Analgesia; Anesthesia; Anesthetics, Dissociative; Animals; Humans; Hyperalgesia; Inflammation; Ketam

2008

Trials

47 trials available for ketamine and Allodynia

ArticleYear
Preventative effect of ketamine on post-surgical hyperalgesia induced at a body part remote from the surgical site.
    Minerva anestesiologica, 2018, Volume: 84, Issue:4

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Hyperalgesia; Hysterectomy; Intraoperative C

2018
Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy.
    The Clinical journal of pain, 2014, Volume: 30, Issue:6

    Topics: Acute Disease; Administration, Intravenous; Adult; Analgesia, Epidural; Analgesics; Chronic Pain; Co

2014
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com

2014
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com

2014
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com

2014
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com

2014
Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Child; Double-Blind Method; Drug Toleranc

2014
Study protocol for a randomised, double-blinded, placebo-controlled, clinical trial of S-ketamine for pain treatment in patients with chronic pancreatitis (RESET trial).
    BMJ open, 2015, Mar-10, Volume: 5, Issue:3

    Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Blind Method; Humans; Hyp

2015
Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cholecystectomy, Laparoscopic;

2015
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
    Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:7

    Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
    Minerva anestesiologica, 2016, Volume: 82, Issue:10

    Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures

2016
The ED50 and ED95 of ketamine for prevention of postoperative hyperalgesia after remifentanil-based anaesthesia in patients undergoing laparoscopic cholecystectomy.
    Swiss medical weekly, 2011, Volume: 141

    Topics: Analgesics; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; Dose-Response Relationship, Dru

2011
A comparison of ketamine and paracetamol for preventing remifentanil induced hyperalgesia in patients undergoing total abdominal hysterectomy.
    International journal of medical sciences, 2012, Volume: 9, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Female; Humans; Hyperalgesia; Hysterectomy; Ketamine; Midd

2012
Low-dose sublingual ketamine does not modulate experimentally induced mechanical hyperalgesia in healthy subjects.
    Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:9

    Topics: Administration, Sublingual; Adult; Analgesics; Double-Blind Method; Female; Humans; Hyperalgesia; Ke

2012
Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo.
    Pain, 2003, Volume: 101, Issue:3

    Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Double-Blind Meth

2003
Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:3

    Topics: Adult; Analgesics, Opioid; Blood Gas Analysis; Cross-Over Studies; Double-Blind Method; Drug Interac

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Blood Pressure; Clo

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor.
    Gastroenterology, 2004, Volume: 126, Issue:3

    Topics: Adult; Area Under Curve; Attention; Cross-Over Studies; Double-Blind Method; Electric Stimulation; E

2004
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans.
    Clinical physiology and functional imaging, 2004, Volume: 24, Issue:2

    Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Bli

2004
Effect of pre-emptive ketamine on sensory changes and postoperative pain after thoracotomy: comparison of epidural and intramuscular routes.
    British journal of anaesthesia, 2004, Volume: 93, Issue:3

    Topics: Adult; Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dou

2004
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid

2005
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
    Anesthesiology, 2005, Volume: 103, Issue:4

    Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges

2005
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
    Anesthesiology, 2005, Volume: 103, Issue:4

    Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges

2005
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
    Anesthesiology, 2005, Volume: 103, Issue:4

    Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges

2005
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
    Anesthesiology, 2005, Volume: 103, Issue:4

    Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges

2005
Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia.
    The Clinical journal of pain, 2006, Volume: 22, Issue:1

    Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Dissociative; Area Under Curve; C

2006
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
    Anesthesiology, 2006, Volume: 105, Issue:5

    Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti

2006
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
    Anesthesiology, 2006, Volume: 105, Issue:5

    Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti

2006
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
    Anesthesiology, 2006, Volume: 105, Issue:5

    Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti

2006
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
    Anesthesiology, 2006, Volume: 105, Issue:5

    Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interacti

2006
Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Adult; Analysis of Variance; Cross-Over Studies; Dose-Response Relationship, Radiation; Excitatory A

2007
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
    Pain, 2007, Volume: 129, Issue:1-2

    Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-B

2007
Pharmacological dissection of the paradoxical pain induced by a thermal grill.
    Pain, 2008, Volume: 135, Issue:3

    Topics: Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagon

2008
Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT.
    European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:12

    Topics: Adult; Aged; Anesthetics, Dissociative; Brain; Cysteine; Female; Fibromyalgia; Follow-Up Studies; Hu

2007
Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.
    Pain, 1994, Volume: 56, Issue:1

    Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans;

1994
Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia.
    Anesthesia and analgesia, 1994, Volume: 78, Issue:2

    Topics: Adult; Analgesia; Double-Blind Method; Female; Fentanyl; Humans; Hyperalgesia; Ketamine; Middle Aged

1994
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
    Pain, 1995, Volume: 63, Issue:2

    Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind

1995
Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans.
    British journal of anaesthesia, 1996, Volume: 76, Issue:6

    Topics: Adult; Anesthesia, Intravenous; Anesthetics, Dissociative; Burns; Dose-Response Relationship, Drug;

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study.
    Pain, 1996, Volume: 66, Issue:1

    Topics: Adult; Anesthetics, Dissociative; Capsaicin; Double-Blind Method; Electric Stimulation; Electrophysi

1996
Local treatment with the N-methyl-D-aspartate receptor antagonist ketamine, inhibit development of secondary hyperalgesia in man by a peripheral action.
    Neuroscience letters, 1997, May-09, Volume: 227, Issue:1

    Topics: Adult; Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Male;

1997
A new method to evaluate central sensitization to pain following surgery. Effect of ketamine.
    Acta anaesthesiologica Scandinavica. Supplementum, 1997, Volume: 110

    Topics: Action Potentials; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Dissociative; Dermatolo

1997
Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo.
    Pain, 1997, Volume: 72, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Burns; Cross-Over Studies; Depression, Chemical; Double-Blind Method; Exc

1997
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:9

    Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi

1997
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:9

    Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi

1997
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:9

    Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi

1997
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:9

    Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi

1997
Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:6

    Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Capsaicin; Cognition;

1998
The effect of naloxone on ketamine-induced effects on hyperalgesia and ketamine-induced side effects in humans.
    Anesthesiology, 1999, Volume: 90, Issue:6

    Topics: Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Male; Naloxone; Narcotic An

1999
The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:6

    Topics: Adult; Analgesics; Analgesics, Opioid; Axons; Capsaicin; Erythema; Female; Fentanyl; Humans; Hyperal

1999
Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans.
    British journal of anaesthesia, 2000, Volume: 84, Issue:2

    Topics: Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Hot Temperature;

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man.
    Pain, 2000, Volume: 86, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Burns; Cross-Over Studies; Double-Blind Method; Excitatory Am

2000
Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans.
    British journal of anaesthesia, 2000, Volume: 85, Issue:4

    Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Me

2000
Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain.
    Pain, 2001, Volume: 91, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Alfentanil; Analgesics; Analgesics, Opioid; Dose-Response Relationsh

2001
'Balanced analgesia' in the perioperative period: is there a place for ketamine?
    Pain, 2001, Volume: 92, Issue:3

    Topics: Aged; Analgesia; Analgesics; Analysis of Variance; Female; Humans; Hyperalgesia; Ketamine; Male; Mid

2001
A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine.
    Anesthesiology, 2001, Volume: 95, Issue:2

    Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Ax

2001
Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia.
    Journal of clinical pharmacology, 2002, Volume: 42, Issue:1

    Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Dose-Response Re

2002

Other Studies

92 other studies available for ketamine and Allodynia

ArticleYear
Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:5

    Topics: Adult; Analgesics, Opioid; Cancer Pain; Female; Humans; Hyperalgesia; Ketamine; Leukemia, Promyelocy

2022
Response After Repeated Ketamine Injections in a Rat Model of Neuropathic Pain.
    Physiological research, 2022, 04-30, Volume: 71, Issue:2

    Topics: Animals; Hyperalgesia; Ketamine; Male; Neuralgia; Pain Measurement; Rats; Rats, Wistar; Sciatic Nerv

2022
Suspected opioid-induced hyperalgesia in an infant following surgery: A case report.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:9

    Topics: Adult; Analgesics, Opioid; Fentanyl; Humans; Hyperalgesia; Infant; Ketamine; Male; Pain

2022
The use of ketamine infusion to dramatically reduce opioid requirements in a patient whose high-dose intrathecal opioid pump was inadvertently cut during surgery.
    Pain practice : the official journal of World Institute of Pain, 2023, Volume: 23, Issue:8

    Topics: Analgesics, Opioid; Chronic Pain; Humans; Hyperalgesia; Infusions, Intravenous; Ketamine; Morphine

2023
A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons.
    Drug discoveries & therapeutics, 2023, Sep-15, Volume: 17, Issue:4

    Topics: Animals; Cyclooxygenase 2; Fentanyl; Hyperalgesia; Inflammation; Ketamine; Neurons; NF-kappa B; Rats

2023
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
    Neuropharmacology, 2020, 01-01, Volume: 162

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2020
Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia.
    Neuroscience letters, 2020, 01-01, Volume: 714

    Topics: Analgesics, Opioid; Animals; Ankle Joint; Brain; Brain Stem; Chronic Pain; Diencephalon; Disease Mod

2020
Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
    European journal of pharmacology, 2020, May-15, Volume: 875

    Topics: Acute Pain; Analgesics; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Comb

2020
Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone: modulation by acute ketamine.
    Journal of neurophysiology, 2020, 09-01, Volume: 124, Issue:3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Tolerance; Excitatory Amino Acid Antagonists; Hy

2020
Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Administration, Cutaneous; Aged; Analgesics; Baclofen; Drug Synergism; Humans; Hyperalgesia; Ketamin

2017
Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine.
    Medicine, 2017, Volume: 96, Issue:15

    Topics: Aged; Analgesics; Female; Hepatectomy; Humans; Hyperalgesia; Incidence; Ketamine; Male; Middle Aged;

2017
Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study.
    European journal of pain (London, England), 2017, Volume: 21, Issue:10

    Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Disease Models, An

2017
Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys.
    Behavioural pharmacology, 2018, Volume: 29, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Conditioning, Operant; Dizocilpine Maleate; Dose-Response R

2018
Ketamine and remote hyperalgesia.
    Minerva anestesiologica, 2018, Volume: 84, Issue:4

    Topics: Double-Blind Method; Human Body; Humans; Hyperalgesia; Ketamine; Receptors, N-Methyl-D-Aspartate

2018
Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression.
    Neuroreport, 2018, 07-04, Volume: 29, Issue:10

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis

2018
Ketamine has anti-hyperalgesic effects and relieves acute pain, but does not prevent persistent postoperative pain (PPP).
    Scandinavian journal of pain, 2015, 04-01, Volume: 7, Issue:1

    Topics: Acute Pain; Analgesics; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Pain, Postoperative

2015
The effect of ketamine on delirium and opioid-induced hyperalgesia in the Intensive Care Unit.
    Anaesthesia, critical care & pain medicine, 2018, Volume: 37, Issue:6

    Topics: Analgesics, Opioid; Critical Care; Delirium; Humans; Hyperalgesia; Hypnotics and Sedatives; Intensiv

2018
Prevention of post-operative hyperalgesia in a heroin-addicted patient on methadone maintenance.
    Journal of clinical pharmacy and therapeutics, 2019, Volume: 44, Issue:3

    Topics: Analgesics, Opioid; Heroin; Humans; Hyperalgesia; Ketamine; Male; Methadone; Middle Aged; Opioid-Rel

2019
Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice.
    Journal of neurosurgical anesthesiology, 2020, Volume: 32, Issue:4

    Topics: Analgesics; Animals; Behavior, Animal; Caveolin 1; Depression; Disease Models, Animal; Freund's Adju

2020
The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain.
    Journal of pain & palliative care pharmacotherapy, 2018, Volume: 32, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, D

2018
Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine.
    BMC veterinary research, 2013, Mar-27, Volume: 9

    Topics: Analgesics; Animals; Disease Models, Animal; Hemorrhage; Hyperalgesia; Ketamine; Pain Measurement; R

2013
Influence of clonidine and ketamine on m-RNA expression in a model of opioid-induced hyperalgesia in mice.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Brain; Clonidine; Disease M

2013
Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Activating Transcription Factor 3; Analysis of Variance; Animals; Cytokines; Ganglia, Spinal; Hot Te

2014
Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study.
    European journal of anaesthesiology, 2015, Volume: 32, Issue:4

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Behavior, Animal; Buprenorphine; Hyperalgesia;

2015
Long-Term Antihyperalgesic and Opioid-Sparing Effects of 5-Day Ketamine and Morphine Infusion ("Burst Ketamine") in Diabetic Neuropathic Rats.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:9

    Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal;

2015
Phosphorylation of the GluN1 subunit in dorsal horn neurons by remifentanil: a mechanism for opioid-induced hyperalgesia.
    Genetics and molecular research : GMR, 2015, Mar-13, Volume: 14, Issue:1

    Topics: Analgesics, Opioid; Animals; Female; Hyperalgesia; Ketamine; Naloxone; Nerve Tissue Proteins; Phosph

2015
Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Analgesics; Animals; Behavior, Animal; Chronic Disease; Complex Regional Pain Syndromes; Disease Mod

2015
Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study.
    European journal of anaesthesiology, 2015, Volume: 32, Issue:10

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Hyperalgesia; Ketamine; Male; Meth

2015
Ketamine for pain management in France, an observational survey.
    Anaesthesia, critical care & pain medicine, 2015, Volume: 34, Issue:6

    Topics: Acute Pain; Aged; Anesthetics, Dissociative; Chronic Pain; Female; France; Health Care Surveys; Huma

2015
Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model.
    Neuroscience letters, 2016, Sep-19, Volume: 631

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Freund's Adjuv

2016
A comparison of intrathecal magnesium and ketamine in attenuating remifentanil-induced hyperalgesia in rats.
    BMC anesthesiology, 2016, 09-06, Volume: 16, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Ketamine; Magnesium Sul

2016
Effects of norketamine enantiomers in rodent models of persistent pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Dr

2008
Selective disturbance of pain sensitivity after social isolation.
    Physiology & behavior, 2009, Jan-08, Volume: 96, Issue:1

    Topics: Analgesics; Animals; Animals, Newborn; Carrageenan; Disease Models, Animal; Hot Temperature; Hyperal

2009
[Ketamine for prevention of postoperative pain: what are the doses and indications?].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:3

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Chronic Disease; Dose-Response Relationship, Drug;

2009
Propofol alters ketamine effect on opiate-induced hyperalgesia.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Drug Interactions; Drug Tolerance; Humans;

2009
Expert panel guidelines (2008). Postoperative pain management in adults and children. SFAR Committees on Pain and Local Regional Anaesthesia and on Standards.
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics, Non-Narcoti

2009
Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation: role of nitric oxide.
    Brain research bulletin, 2009, Aug-14, Volume: 79, Issue:6

    Topics: Animals; Carrageenan; Electroacupuncture; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hot

2009
[Effects of general anesthesia using ketamine and remifentanil on postoperative pain management for patients undergoing laparotomy].
    Masui. The Japanese journal of anesthesiology, 2009, Volume: 58, Issue:6

    Topics: Adult; Aged; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Elective Surgical Procedu

2009
S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.
    Anesthesiology, 2009, Volume: 111, Issue:4

    Topics: Adolescent; Adult; Algorithms; Anesthetics, Dissociative; Cardiac Output; Dose-Response Relationship

2009
Spinally applied ketamine or morphine attenuate peripheral inflammation and hyperalgesia in acute and chronic phases of experimental arthritis.
    Brain, behavior, and immunity, 2010, Volume: 24, Issue:3

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Animals; Arthritis, Experimental; Chronic Disease; Fe

2010
Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug

2010
Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.
    Molecular pain, 2009, Dec-30, Volume: 5

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Aci

2009
Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intrad

2010
Opioid-induced hyperalgesia: low-dose ketamine does work for some orthopaedic problems already.
    British journal of anaesthesia, 2010, Volume: 104, Issue:5

    Topics: Analgesics, Opioid; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Orthopedic Pr

2010
Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain.
    Molecular pain, 2010, Sep-06, Volume: 6

    Topics: 2-Aminoadipic Acid; Analgesics; Animals; Astrocytes; Dose-Response Relationship, Drug; Drug Therapy,

2010
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
    European journal of pharmacology, 2010, Nov-25, Volume: 647, Issue:1-3

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glut

2010
Buprenorphine-induced hyperalgesia in the rat.
    European journal of pharmacology, 2011, Jan-25, Volume: 651, Issue:1-3

    Topics: Analgesics; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Administration Schedule;

2011
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain.
    Journal of neuroinflammation, 2011, Jan-24, Volume: 8, Issue:1

    Topics: Analgesics; Animals; Astrocytes; Behavior, Animal; Enzyme Activation; Hyperalgesia; Injections, Spin

2011
Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain.
    Neuro-Signals, 2011, Volume: 19, Issue:1

    Topics: Analgesics; Analysis of Variance; Animals; CD11b Antigen; Cell Count; Disease Models, Animal; Dose-R

2011
Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
    Anesthesiology, 2011, Volume: 115, Issue:1

    Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Cold Temperature; Data Interpretation, Statisti

2011
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni

2011
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:3

    Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids;

2011
Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion.
    Pain practice : the official journal of World Institute of Pain, 2012, Volume: 12, Issue:2

    Topics: Analgesics, Opioid; Humans; Hydromorphone; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Mid

2012
Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
    The journal of pain, 2011, Volume: 12, Issue:10

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Carrageenan; Disease Models, Animal; Excitatory A

2011
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:5

    Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; E

2011
A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats.
    Anesthesiology, 2011, Volume: 115, Issue:4

    Topics: Anesthetics, Dissociative; Animals; Antidepressive Agents; Behavior, Animal; Cold Temperature; Corti

2011
Suspected opioid-induced hyperalgesia in an infant.
    British journal of anaesthesia, 2012, Volume: 108, Issue:1

    Topics: Abdominal Wall; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Dexmedetomi

2012
Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-30, Volume: 31, Issue:48

    Topics: Analgesia; Analgesics; Animals; Cells, Cultured; Hyperalgesia; Ketamine; Male; Mice; Mice, Transgeni

2011
Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice.
    Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:1

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Hyperalgesia;

2013
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
    Neuropharmacology, 2002, Volume: 43, Issue:6

    Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell

2002
Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:1

    Topics: Administration, Topical; Amitriptyline; Anesthetics, Dissociative; Animals; Antidepressive Agents, T

2003
Effect of long-term ketamine administration on vocalization to paw pressure and on spinal wind-up activity in monoarthritic rats.
    The International journal of neuroscience, 2003, Volume: 113, Issue:9

    Topics: Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Arthritis, Infectious; Chronic D

2003
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
    Annales francaises d'anesthesie et de reanimation, 2004, Volume: 23, Issue:5

    Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal

2004
Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia.
    British journal of anaesthesia, 2004, Volume: 93, Issue:3

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Drug Interactions; Excitatory Amino Acid Antag

2004
Preventive analgesia to reduce wound hyperalgesia and persistent postsurgical pain: not an easy path.
    Anesthesiology, 2005, Volume: 103, Issue:4

    Topics: Analgesia, Epidural; Humans; Hyperalgesia; Ketamine; Pain, Postoperative

2005
[Comparison of the suppressive effects of tramadol and low-dose ketamine on the patients with postoperative hyperalgesia after remifentanil-based anaesthesia].
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2005, Volume: 23, Issue:5

    Topics: Adult; Analgesics, Opioid; Anesthesia; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Post

2005
A single dose of intrathecal morphine in rats induces long-lasting hyperalgesia: the protective effect of prior administration of ketamine.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:6

    Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Spinal; Ketamine; Male; Morphi

2005
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.
    Neuropharmacology, 2006, Volume: 50, Issue:6

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Aci

2006
Characterization of the antinociceptive effect of oxycodone in male and female rats.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 83, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

2006
An evaluation of a polyamine-deficient diet for the treatment of inflammatory pain.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:6

    Topics: Analgesia; Analgesics; Animals; Carrageenan; Diet; Hindlimb; Hyperalgesia; Inflammation; Ketamine; M

2006
Opioid-induced hyperalgesia.
    European journal of anaesthesiology, 2007, Volume: 24, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Femoral Artery; Fentanyl; Humans; Hyperalgesia; Ketamine; Male; Midd

2007
Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification - evidence of central sensitization.
    Neurogastroenterology and motility, 2007, Volume: 19, Issue:4

    Topics: Adult; Analgesics; Electric Stimulation; Esophagus; Evoked Potentials; Female; Humans; Hydrogen-Ion

2007
Ketamine as an adjuvant for treatment of cancer pain in children and adolescents.
    The journal of pain, 2007, Volume: 8, Issue:6

    Topics: Adolescent; Age Factors; Analgesics, Opioid; Child; Child, Preschool; Dose-Response Relationship, Dr

2007
Ketamine blocks enhancement of spinal long-term potentiation in chronic opioid treated rats.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:5

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Animals; Chronic Disease; Drug Synergism; Electric St

2008
The effect of abdominal surgery on thresholds to thermal and mechanical stimulation in sheep.
    Pain, 1995, Volume: 60, Issue:2

    Topics: Abdomen; Animals; Female; Hot Temperature; Hyperalgesia; Ketamine; Pain Threshold; Postoperative Per

1995
Evidence of a role for N-methyl-D-aspartate (NMDA) receptors in the facilitation of tail withdrawal after spinal transection.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1

    Topics: Analgesics; Animals; Cordotomy; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal;

1994
Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy.
    Brain research, 1996, Apr-09, Volume: 715, Issue:1-2

    Topics: Animals; Behavior, Animal; Cold Temperature; Dose-Response Relationship, Drug; Excitatory Amino Acid

1996
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate

1997
Reduction in hyperalgesia and intrathecal morphine requirements by low-dose ketamine infusion.
    Journal of pain and symptom management, 1997, Volume: 14, Issue:3

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Humans; Hyp

1997
Antinociceptive effect of the S(+)-enantiomer of ketamine on carrageenan hyperalgesia after intrathecal administration in rats.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:3

    Topics: Analgesics; Anesthetics, Dissociative; Animals; Carrageenan; Hyperalgesia; Injections, Spinal; Ketam

1998
Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:3

    Topics: Anesthetics, Dissociative; Animals; Female; Hyperalgesia; Injections, Spinal; Ketamine; Nerve Compre

1998
[Suppressive effects of ketamine on neuropathic pain].
    Masui. The Japanese journal of anesthesiology, 1998, Volume: 47, Issue:2

    Topics: Acute Disease; Anesthetics, Dissociative; Animals; Disease Models, Animal; Dose-Response Relationshi

1998
Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists.
    Neuroscience, 1999, Volume: 89, Issue:3

    Topics: Analgesics; Animals; Biphenyl Compounds; Excitatory Amino Acid Antagonists; Gene Expression Regulati

1999
Generalized hyperalgesia and allodynia following abrupt cessation of subcutaneous ketamine infusion.
    Palliative medicine, 1999, Volume: 13, Issue:5

    Topics: Aged; Analgesics; Breast Neoplasms; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections

1999
Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine.
    Anesthesiology, 2000, Volume: 92, Issue:2

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fe

2000
Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation.
    Anesthesiology, 2000, Volume: 93, Issue:2

    Topics: Adrenergic alpha-Antagonists; Analgesia; Analgesics; Animals; Carrageenan; Drug Administration Sched

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Alfentanil; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Excitatory Amino Acid An

2000
Treatment of central post-stroke pain with oral ketamine.
    Pain, 2001, Volume: 92, Issue:1-2

    Topics: Administration, Oral; Aged; Analgesics; Female; Humans; Hyperalgesia; Ketamine; Neuralgia; Stroke

2001
Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model.
    Acta anaesthesiologica Sinica, 2001, Volume: 39, Issue:3

    Topics: Analgesia; Analgesics; Animals; Formaldehyde; Hyperalgesia; Injections, Intravenous; Injections, Spi

2001
Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:9

    Topics: Analgesia, Patient-Controlled; Analgesics; Brain Stem; Cervical Vertebrae; Child; Diazepam; Drug Res

2001
The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:5

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Excitatory Amino Acid Antagonists; Fentanyl; Hyperalges

2002
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
    European journal of pharmacology, 1992, Aug-25, Volume: 219, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; C

1992