Page last updated: 2024-09-03

ly 293558 and Allodynia

ly 293558 has been researched along with Allodynia in 4 studies

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	2 (50.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alt, A; Arnold, BM; Bell, MG; Bleakman, D; Bleisch, TJ; Buckmaster, JL; Castano, AM; Del Prado, M; Dominguez, E; Escribano, A; Filla, SA; Ho, KH; Hudziak, KJ; Iyengar, S; Jones, CK; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM; Stack, DR; Stratford, RE; Winter, MA; Wu, Z	1
Lam, V; Schettler, J; Wallace, MS	1
Brennan, TJ; Lee, HJ; Pogatzki-Zahn, EM	1
Caruso, R; Chappell, AS; Gracely, RH; Hostetter, MP; Lee, G; Max, MB; Sang, CN; Schoepp, DD; Whitcup, S	1

Trials

2 trial(s) available for ly 293558 and Allodynia

Article	Year
NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia. Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:12 Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Isoquinolines; Male; Pain; Pain Measurement; Prodrugs; Receptors, AMPA; Receptors, Kainic Acid; Sensory System Agents; Tetrazoles; Young Adult	2012
AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. Anesthesiology, 1998, Volume: 89, Issue:5 Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Isoquinolines; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Receptors, AMPA; Receptors, Kainic Acid; Skin; Tetrazoles	1998

Article

Year

NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia.

Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:12

Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Isoquinolines; Male; Pain; Pain Measurement; Prodrugs; Receptors, AMPA; Receptors, Kainic Acid; Sensory System Agents; Tetrazoles; Young Adult

2012

AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans.

Anesthesiology, 1998, Volume: 89, Issue:5

Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Isoquinolines; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Receptors, AMPA; Receptors, Kainic Acid; Skin; Tetrazoles

1998

Other Studies

2 other study(ies) available for ly 293558 and Allodynia

Article	Year
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain. Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biological Availability; Cell Line; Disease Models, Animal; Humans; Hyperalgesia; Pain; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord	2005
The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain. The journal of pain, 2006, Volume: 7, Issue:10 Topics: Afferent Pathways; Analgesics; Animals; Carboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Isoquinolines; Male; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles; Treatment Outcome	2006

Article

Year

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biological Availability; Cell Line; Disease Models, Animal; Humans; Hyperalgesia; Pain; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord

2005

The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain.

The journal of pain, 2006, Volume: 7, Issue:10

Topics: Afferent Pathways; Analgesics; Animals; Carboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Isoquinolines; Male; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles; Treatment Outcome

2006