midazolam has been researched along with Allodynia in 16 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil." | 6.68 | Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995) |
| "Furthermore, the mechanical allodynia was significantly attenuated after PUR administration." | 5.48 | Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats. ( Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W, 2018) |
| " Here, we show that inhibition of spinal CA activity with acetazolamide (ACT) reduces neuropathic allodynia." | 3.76 | Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. ( Asiedu, M; Kaila, K; Ossipov, MH; Price, TJ, 2010) |
| "The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil." | 2.68 | Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995) |
| "The results showed that CCI-ION induced hyperalgesia, which was attenuated by lidocaine or carbamazepine, developed anxiety-like behavior, which was reduced only by midazolam, and displayed a reduced number of 50-kHz calls, compared to sham." | 1.72 | Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs. ( Araya, EI; Baggio, DF; Chichorro, JG; Koren, LO; Schwarting, RKW, 2022) |
| "Furthermore, the mechanical allodynia was significantly attenuated after PUR administration." | 1.48 | Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats. ( Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W, 2018) |
| "Heat facial hyperalgesia was assessed on day 6 after the inoculation, and on this time point rats were submitted to the elevated plus maze and the light-dark transition tests." | 1.43 | Evaluation of heat hyperalgesia and anxiety like-behaviors in a rat model of orofacial cancer. ( Chichorro, JG; Dos Reis, RC; Gambeta, E; Kopruszinski, CM; Zanoveli, JM, 2016) |
| " For both experiments, cumulative morphine anti-nociceptive dose-response (ED50) was tested and hyperactive behaviors such as jumping and scratching were recorded." | 1.40 | Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury. ( Chen, L; Mao, J; Martyn, JA; Song, L; Wang, S; Zuo, Y, 2014) |
| "The patient also developed hyperalgesia, allodynia, and photophobia and became extremely irritable upon handling." | 1.38 | Suspected opioid-induced hyperalgesia in an infant. ( Chalkiadis, GA; Hallett, BR, 2012) |
| "Saline-treated CCI rats developed thermal hyperalgesia on Day 3 with a more pronounced effect on Day 7." | 1.35 | Midazolam administration reverses thermal hyperalgesia and prevents gamma-aminobutyric acid transporter loss in a rodent model of neuropathic pain. ( Miletic, G; Miletic, V; Shih, A; Smith, LJ, 2008) |
| "Thermal hyperalgesia and mechanical allodynia induced by chronic constriction nerve injury (CCI) in rats were attenuated by the short-acting benzodiazepine midazolam (20=10>5 mug>vehicle) administered intrathecally once daily for 7 postoperative days." | 1.33 | Intrathecal midazolam regulates spinal AMPA receptor expression and function after nerve injury in rats. ( Lim, G; Lim, J; Mao, J; Sung, B; Wang, S, 2006) |
| "Midazolam caused hyperalgesia when administered intracerebroventricularly (i." | 1.30 | Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level. ( Duarte, ID; Francischi, JN; Salgado, JV; Tatsuo, MA; Yokoro, CM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Araya, EI | 1 |
| Baggio, DF | 1 |
| Koren, LO | 1 |
| Schwarting, RKW | 1 |
| Chichorro, JG | 2 |
| Chen, J | 1 |
| Li, H | 1 |
| Lim, G | 2 |
| McCabe, MF | 1 |
| Zhao, W | 1 |
| Yang, Y | 1 |
| Ma, W | 1 |
| Li, N | 1 |
| Song, L | 1 |
| Wang, S | 2 |
| Zuo, Y | 1 |
| Chen, L | 1 |
| Martyn, JA | 1 |
| Mao, J | 2 |
| Ralvenius, WT | 1 |
| Benke, D | 1 |
| Acuña, MA | 1 |
| Rudolph, U | 1 |
| Zeilhofer, HU | 1 |
| Gambeta, E | 1 |
| Kopruszinski, CM | 1 |
| Dos Reis, RC | 1 |
| Zanoveli, JM | 1 |
| Asiedu, M | 1 |
| Ossipov, MH | 1 |
| Kaila, K | 1 |
| Price, TJ | 1 |
| Narita, M | 2 |
| Niikura, K | 1 |
| Nanjo-Niikura, K | 1 |
| Furuya, M | 1 |
| Yamashita, A | 1 |
| Saeki, M | 1 |
| Matsushima, Y | 1 |
| Imai, S | 1 |
| Shimizu, T | 1 |
| Asato, M | 1 |
| Kuzumaki, N | 1 |
| Okutsu, D | 1 |
| Miyoshi, K | 1 |
| Suzuki, M | 1 |
| Tsukiyama, Y | 1 |
| Konno, M | 1 |
| Yomiya, K | 1 |
| Matoba, M | 1 |
| Suzuki, T | 1 |
| Hallett, BR | 1 |
| Chalkiadis, GA | 1 |
| Nattermann, C | 1 |
| Fimmers, R | 1 |
| Bayer, B | 1 |
| Lim, J | 1 |
| Sung, B | 1 |
| Shih, A | 1 |
| Miletic, V | 1 |
| Miletic, G | 1 |
| Smith, LJ | 1 |
| Anseloni, VC | 1 |
| Gold, MS | 1 |
| Park, KM | 1 |
| Max, MB | 1 |
| Robinovitz, E | 1 |
| Gracely, RH | 1 |
| Bennett, GJ | 1 |
| Tatsuo, MA | 2 |
| Yokoro, CM | 2 |
| Salgado, JV | 2 |
| Pesquero, SM | 1 |
| Santana, MA | 1 |
| Francischi, JN | 2 |
| Duarte, ID | 1 |
| Klepstad, P | 1 |
| Borchgrevink, P | 1 |
| Hval, B | 1 |
| Flaat, S | 1 |
| Kaasa, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery[NCT03534895] | Phase 4 | 168 participants (Anticipated) | Interventional | 2019-05-31 | Not yet recruiting | ||
| Does Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Observational Study in Open Inguinal Hernia Repair[NCT03499730] | 300 participants (Actual) | Observational | 2018-09-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for midazolam and Allodynia
| Article | Year |
|---|---|
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind | 1995 |
15 other studies available for midazolam and Allodynia
| Article | Year |
|---|---|
Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs.
Topics: Analgesics; Animals; Carbamazepine; Hyperalgesia; Lidocaine; Male; Midazolam; Neuralgia; Rats; Trige | 2022 |
Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats.
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Hedgehog Proteins; Hyperalgesia; Male; Midazolam; | 2018 |
Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury.
Topics: Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hyperalgesia; Hyperkinesis; Hypnotics and Sedati | 2014 |
Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.
Topics: Analgesia; Animals; Arginine; Benzodiazepines; Diazepam; GABA Modulators; Gene Expression; Histidine | 2015 |
Evaluation of heat hyperalgesia and anxiety like-behaviors in a rat model of orofacial cancer.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Anxiety; Cell Line, Tumor; Facial Neoplasms; Hot Temperatu | 2016 |
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.
Topics: Acetazolamide; Anesthetics, Intravenous; Animals; Carbonic Anhydrase Inhibitors; Disease Models, Ani | 2010 |
Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.
Topics: Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Electroencephalography; Electromyog | 2011 |
Suspected opioid-induced hyperalgesia in an infant.
Topics: Abdominal Wall; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Dexmedetomi | 2012 |
[Irritable bowel syndrome: colonoscopy painful and difficult?].
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Colonoscopy; Dose-Response Relationship, Drug; Female; H | 2004 |
Intrathecal midazolam regulates spinal AMPA receptor expression and function after nerve injury in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Modulators; Hyperalgesia; In | 2006 |
Midazolam administration reverses thermal hyperalgesia and prevents gamma-aminobutyric acid transporter loss in a rodent model of neuropathic pain.
Topics: Animals; Disease Models, Animal; GABA Plasma Membrane Transport Proteins; Hot Temperature; Hyperalge | 2008 |
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
Topics: Animals; Antineoplastic Agents; Flumazenil; Freund's Adjuvant; GABA Agonists; GABA Antagonists; GABA | 2008 |
Hyperalgesic effect induced by barbiturates, midazolam and ethanol: pharmacological evidence for GABA-A receptor involvement.
Topics: Animals; Barbiturates; Central Nervous System Depressants; Ethanol; GABA Antagonists; GABA Modulator | 1997 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor.
Topics: Analgesia, Patient-Controlled; Analgesics; Brain Stem; Cervical Vertebrae; Child; Diazepam; Drug Res | 2001 |