valproic acid has been researched along with Allodynia in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to evaluate the effect of valproic acid (VPA) and progesterone (P4) in a rat model of endometriosis on serum tumor necrosis factor-α (TNF-α) levels, hot plate and tail-flick latencies, lesion size, and body weight." | 7.78 | Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, M; Liu, X; Zhang, Y, 2012) |
| "One primary goal of medical treatment of endometriosis is to alleviate pain and there is a pressing need for new therapeutics for endometriosis with better efficacy and side-effect profiles." | 5.37 | Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, X; Zhao, T; Zhen, X, 2011) |
| " This study was designed to evaluate the effect of valproic acid (VPA) and progesterone (P4) in a rat model of endometriosis on serum tumor necrosis factor-α (TNF-α) levels, hot plate and tail-flick latencies, lesion size, and body weight." | 3.78 | Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, M; Liu, X; Zhang, Y, 2012) |
| "We report the predictors of allodynia in migraine and the effect of divalproate or amitriptyline in alleviating allodynia." | 2.78 | Allodynia in migraine: clinical observation and role of prophylactic therapy. ( Bhoi, SK; Kalita, J; Misra, UK, 2013) |
| "One primary goal of medical treatment of endometriosis is to alleviate pain and there is a pressing need for new therapeutics for endometriosis with better efficacy and side-effect profiles." | 1.37 | Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, X; Zhao, T; Zhen, X, 2011) |
| " Adenomyosis was induced in 55 female ICR mice neonatally dosed with tamoxifen, while another 8 (group C) were dosed with solvent only." | 1.37 | The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (l-THP) and andrographolide. ( Carter, AV; Guo, SW; Mao, X; Wang, Y; Zhen, X, 2011) |
| " In this study, we evaluated the effect of valproic acid (VPA) in ICR mice with adenomyosis, induced by neonatal dosing with tamoxifen." | 1.37 | Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis. ( Guo, SW; Liu, X, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Imado, E | 1 |
| Sun, S | 1 |
| Abawa, AR | 1 |
| Tahara, T | 1 |
| Kochi, T | 1 |
| Huynh, TNB | 1 |
| Asano, S | 1 |
| Hasebe, S | 1 |
| Nakamura, Y | 1 |
| Hisaoka-Nakashima, K | 1 |
| Kotake, Y | 1 |
| Irifune, M | 1 |
| Tsuga, K | 1 |
| Takuma, K | 1 |
| Morioka, N | 1 |
| Kiguchi, N | 1 |
| Ago, Y | 1 |
| Yoshizumi, M | 1 |
| Eisenach, JC | 2 |
| Hayashida, K | 2 |
| Zhao, T | 1 |
| Liu, X | 3 |
| Zhen, X | 2 |
| Guo, SW | 4 |
| Mao, X | 1 |
| Wang, Y | 1 |
| Carter, AV | 1 |
| Hobo, S | 1 |
| Liu, M | 1 |
| Zhang, Y | 1 |
| Misra, UK | 1 |
| Kalita, J | 1 |
| Bhoi, SK | 1 |
| Winkler, I | 1 |
| Blotnik, S | 1 |
| Shimshoni, J | 1 |
| Yagen, B | 1 |
| Devor, M | 1 |
| Bialer, M | 1 |
1 trial available for valproic acid and Allodynia
| Article | Year |
|---|---|
Allodynia in migraine: clinical observation and role of prophylactic therapy.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Child; Comorbidity; Female; Humans; Hype | 2013 |
8 other studies available for valproic acid and Allodynia
| Article | Year |
|---|---|
Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation.
Topics: Animals; Autism Spectrum Disorder; Calcium; Disease Models, Animal; Female; Humans; Hyperalgesia; Ma | 2022 |
Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Down-Regulation; Excitatory Amino Acid Transp | 2013 |
Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats.
Topics: Acid Sensing Ion Channels; Analgesics, Non-Narcotic; Animals; Berberine Alkaloids; Calcitonin Gene-R | 2011 |
The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (l-THP) and andrographolide.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine Alkaloids; Dit | 2011 |
Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Endometriosis; Female; Hyperalgesia; Mice; Mice | 2011 |
Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Transp | 2011 |
Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats.
Topics: Animals; Body Weight; Disease Models, Animal; Endometriosis; Female; Histone Deacetylase Inhibitors; | 2012 |
Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Hyperalgesia; Isomerism; Ligation; Male; Pain; Pain Measuremen | 2005 |