flumazenil has been researched along with Allodynia in 9 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam." | 3.74 | Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008) |
| "It is associated with allodynia and hyperalgesia." | 1.48 | Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. ( Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS, 2018) |
| "At doses producing already maximal antihyperalgesia, HZ166 was devoid of sedation and motor impairment, and showed no loss of analgesic activity during a 9-day chronic treatment period (i." | 1.37 | HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. ( Benke, D; Besson, M; Cook, JM; Daali, Y; Desmeules, J; Di Lio, A; Edwankar, R; Wang, ZJ; Zeilhofer, HU, 2011) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "The induction of hyperalgesia by co-exposure to MFs and diazepam was also blocked by flumazenil." | 1.33 | Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields. ( Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD, 2005) |
| "Midazolam caused hyperalgesia when administered intracerebroventricularly (i." | 1.30 | Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level. ( Duarte, ID; Francischi, JN; Salgado, JV; Tatsuo, MA; Yokoro, CM, 1999) |
| "Tolerance developed by day 10, and hyperalgesia was seen 12 hr after removal of ethanol." | 1.30 | Effects of benzodiazepines on acute and chronic ethanol-induced nociception in rats. ( Gatch, MB, 1999) |
| "Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49 degrees C water, after the release of the tourniquet." | 1.29 | Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines. ( Cartmell, SM; Mitchell, D, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Souza, A | 1 |
| Martins, DF | 1 |
| Medeiros, LF | 1 |
| Nucci-Martins, C | 1 |
| Martins, TC | 1 |
| Siteneski, A | 1 |
| Caumo, W | 1 |
| Dos Santos, ARS | 1 |
| Torres, ILS | 1 |
| Di Lio, A | 1 |
| Benke, D | 1 |
| Besson, M | 1 |
| Desmeules, J | 1 |
| Daali, Y | 1 |
| Wang, ZJ | 1 |
| Edwankar, R | 1 |
| Cook, JM | 1 |
| Zeilhofer, HU | 1 |
| Quintero, L | 2 |
| Cardenas, R | 1 |
| Suarez-Roca, H | 2 |
| Jeong, JH | 1 |
| Choi, KB | 1 |
| Moon, NJ | 1 |
| Park, ES | 1 |
| Sohn, UD | 1 |
| Leal, L | 1 |
| Silva, JA | 1 |
| Pinerua-Shuhaibar, L | 1 |
| Anseloni, VC | 1 |
| Gold, MS | 1 |
| Cartmell, SM | 1 |
| Mitchell, D | 1 |
| Tatsuo, MA | 1 |
| Salgado, JV | 1 |
| Yokoro, CM | 1 |
| Duarte, ID | 1 |
| Francischi, JN | 1 |
| Gatch, MB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery[NCT03534895] | Phase 4 | 168 participants (Anticipated) | Interventional | 2019-05-31 | Not yet recruiting | ||
| Does Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Observational Study in Open Inguinal Hernia Repair[NCT03499730] | 300 participants (Actual) | Observational | 2018-09-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for flumazenil and Allodynia
| Article | Year |
|---|---|
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Mod | 2018 |
HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Rece | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; G | 2005 |
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyper | 2008 |
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
Topics: Animals; Antineoplastic Agents; Flumazenil; Freund's Adjuvant; GABA Agonists; GABA Antagonists; GABA | 2008 |
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-R | 1993 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons | 1999 |
Effects of benzodiazepines on acute and chronic ethanol-induced nociception in rats.
Topics: Analgesics; Animals; Benzodiazepines; Central Nervous System Depressants; Ethanol; Flumazenil; GABA | 1999 |