Page last updated: 2024-10-27

flumazenil and Allodynia

flumazenil has been researched along with Allodynia in 9 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Research Excerpts

ExcerptRelevanceReference
"We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam."3.74Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008)
"It is associated with allodynia and hyperalgesia."1.48Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. ( Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS, 2018)
"At doses producing already maximal antihyperalgesia, HZ166 was devoid of sedation and motor impairment, and showed no loss of analgesic activity during a 9-day chronic treatment period (i."1.37HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. ( Benke, D; Besson, M; Cook, JM; Daali, Y; Desmeules, J; Di Lio, A; Edwankar, R; Wang, ZJ; Zeilhofer, HU, 2011)
"Diazepam effects were blocked by flumazenil."1.37Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011)
"The induction of hyperalgesia by co-exposure to MFs and diazepam was also blocked by flumazenil."1.33Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields. ( Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD, 2005)
"Midazolam caused hyperalgesia when administered intracerebroventricularly (i."1.30Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level. ( Duarte, ID; Francischi, JN; Salgado, JV; Tatsuo, MA; Yokoro, CM, 1999)
"Tolerance developed by day 10, and hyperalgesia was seen 12 hr after removal of ethanol."1.30Effects of benzodiazepines on acute and chronic ethanol-induced nociception in rats. ( Gatch, MB, 1999)
"Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49 degrees C water, after the release of the tourniquet."1.29Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines. ( Cartmell, SM; Mitchell, D, 1993)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Souza, A1
Martins, DF1
Medeiros, LF1
Nucci-Martins, C1
Martins, TC1
Siteneski, A1
Caumo, W1
Dos Santos, ARS1
Torres, ILS1
Di Lio, A1
Benke, D1
Besson, M1
Desmeules, J1
Daali, Y1
Wang, ZJ1
Edwankar, R1
Cook, JM1
Zeilhofer, HU1
Quintero, L2
Cardenas, R1
Suarez-Roca, H2
Jeong, JH1
Choi, KB1
Moon, NJ1
Park, ES1
Sohn, UD1
Leal, L1
Silva, JA1
Pinerua-Shuhaibar, L1
Anseloni, VC1
Gold, MS1
Cartmell, SM1
Mitchell, D1
Tatsuo, MA1
Salgado, JV1
Yokoro, CM1
Duarte, ID1
Francischi, JN1
Gatch, MB1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery[NCT03534895]Phase 4168 participants (Anticipated)Interventional2019-05-31Not yet recruiting
Does Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Observational Study in Open Inguinal Hernia Repair[NCT03499730]300 participants (Actual)Observational2018-09-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

9 other studies available for flumazenil and Allodynia

ArticleYear
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
    Brain research, 2018, 03-01, Volume: 1682

    Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Mod

2018
HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain.
    Neuropharmacology, 2011, Volume: 60, Issue:4

    Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Rece

2011
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni

2011
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
    Archives of pharmacal research, 2005, Volume: 28, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; G

2005
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
    Behavioural brain research, 2008, May-16, Volume: 189, Issue:1

    Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyper

2008
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
    The journal of pain, 2008, Volume: 9, Issue:8

    Topics: Animals; Antineoplastic Agents; Flumazenil; Freund's Adjuvant; GABA Agonists; GABA Antagonists; GABA

2008
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-R

1993
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
    European journal of pharmacology, 1999, Apr-01, Volume: 370, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons

1999
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
    European journal of pharmacology, 1999, Apr-01, Volume: 370, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons

1999
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
    European journal of pharmacology, 1999, Apr-01, Volume: 370, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons

1999
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
    European journal of pharmacology, 1999, Apr-01, Volume: 370, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Respons

1999
Effects of benzodiazepines on acute and chronic ethanol-induced nociception in rats.
    Alcoholism, clinical and experimental research, 1999, Volume: 23, Issue:11

    Topics: Analgesics; Animals; Benzodiazepines; Central Nervous System Depressants; Ethanol; Flumazenil; GABA

1999