ibuprofen has been researched along with Allodynia in 49 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| " Both ibuprofen and L-arginine exert antiallodynic effects on chronic constriction injury (CCI)-induced cold allodynia." | 7.83 | Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy. ( Abd-Alkhalek, HA; El-Bakly, WM; El-Lithy, GM; Hamza, M; Masoud, SI; Matboli, M, 2016) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "The subsequent development of mechanical hyperalgesia to pinprick stimuli was then measured at various time points using a 74." | 6.68 | Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis. ( Cruwys, SC; Kidd, BL; Morris, VH, 1997) |
| " For comparison, we used a previously established model of repeated noxious pinching of an interdigital skin web which induces a hyperalgesia to pressure (rated via visual analogue scale), and topical application of capsaicin which leads to quantifiable flare and allodynia responses." | 5.08 | Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man. ( Brune, K; Forster, C; Geisslinger, G; Handwerker, HO; Kilo, S, 1995) |
| " Both ibuprofen and L-arginine exert antiallodynic effects on chronic constriction injury (CCI)-induced cold allodynia." | 3.83 | Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy. ( Abd-Alkhalek, HA; El-Bakly, WM; El-Lithy, GM; Hamza, M; Masoud, SI; Matboli, M, 2016) |
| " These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain." | 3.80 | Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014) |
| "9 mg/kg, CARR) hypersensitivity, whereas ibuprofen (CARR, mechanical allodynia) and celecoxib (CARR, thermal hyperalgesia; CFA, mechanical allodynia) failed to reach maximum efficacy." | 3.80 | S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. ( Gris, G; Merlos, M; Portillo-Salido, E; Vela, JM; Zamanillo, D, 2014) |
| " Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia." | 3.79 | Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013) |
| " This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation." | 3.79 | Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " Spinal pretreatment with cyclooxygenase (10 and 30 microg (S)-(+)-ibuprofen; and 3 and 30 microg ketorolac) and nitric oxide synthase (33 and 100 microg N(G) Nitro-L-arginine methyl ester hydrochloride (L-NAME) and 10 microg thiocitrulline) inhibitors resulted in no specific anti-allodynia." | 3.74 | Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase. ( Doom, CM; Maruyama, KP; Nanigian, DB; Sorkin, LS, 2008) |
| "Duloxetine, a selective but balanced serotonergic and noradrenergic reuptake inhibitor, was evaluated in the acute nociceptive pain models of tail flick and hot plate in mice and in the persistent and/or inflammatory pain models of acetic acid-induced writhing in mice, carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats, and capsaicin-induced mechanical allodynia in rats." | 3.73 | Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2005) |
| "Only gabapentin suppressed the secondary mechanical hyperalgesia-evoked neural response in a region of the brainstem's descending pain modulatory system (right nucleus cuneiformis) and left (contralateral) posterior insular cortex and secondary somatosensory cortex." | 2.82 | Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development. ( Andersson, J; Kong, Y; Mezue, M; Tracey, I; Wanigasekera, V, 2016) |
| "We found no influence on postoperative pain after high-dose remifentanil in patients undergoing pancreaticoduodenectomy." | 2.82 | Influence of high-dose intraoperative remifentanil with intravenous ibuprofen on postoperative morphine consumption in patients undergoing pancreaticoduodenectomy: a randomized trial. ( Cho, YJ; Hong, DM; Jeon, Y; Kim, TK; Koo, CH, 2016) |
| "Mechanical and thermal hyperalgesia had been induced 24 h before by irradiating skin patches on the ventral side of the upper leg." | 2.69 | Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. ( Bickel, A; Dorfs, S; Forster, C; Handwerker, OH; Schmelz, M; Uhl, W, 1998) |
| "The subsequent development of mechanical hyperalgesia to pinprick stimuli was then measured at various time points using a 74." | 2.68 | Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis. ( Cruwys, SC; Kidd, BL; Morris, VH, 1997) |
| "Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0." | 1.62 | Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021) |
| "Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions." | 1.51 | The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel. ( De Logu, F; De Siena, G; Geppetti, P; Landini, L; Li Puma, S; Nassini, R; Patacchini, R; Poli, G; Preti, D; Tsagareli, MG; Tuccinardi, T, 2019) |
| "The consequences of chronic insufficient sleep for health remain uncertain." | 1.46 | Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017) |
| "We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms." | 1.46 | Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia. ( Cañizares, FJ; Cobos, EJ; Entrena, JM; Fernández-Segura, E; Montilla-García, Á; Perazzoli, G; Portillo-Salido, E; Tejada, MÁ, 2017) |
| "Control of postoperative pain is far from satisfactory." | 1.43 | Nitric oxide is involved in ibuprofen preemptive analgesic effect in the plantar incisional model of postsurgical pain in mice. ( Bahr, MH; Hamza, M; Masoud, SI; Saad, SS, 2016) |
| "Attenuation of hyperalgesia of inflamed TMJ by NSAIDs might be associated with their role in blocking upregulation of trigeminal ganglionic Nav1." | 1.43 | Non-steroidal Anti-inflammatory Drugs Attenuate Hyperalgesia and Block Upregulation of Trigeminal Ganglionic Sodium Channel 1.7 after Induction of Temporomandibular Joint Inflammation in Rats. ( Bi, RY; Ding, Y; Gan, YH, 2016) |
| "Ibuprofen was used as a reference compound in each test." | 1.38 | Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu. ( Brownell, L; Hodges, M; Jia, Q; Yimam, M, 2012) |
| "Paw volume, thermal hyperalgesia, mechanical allodynia, joint stiffness and mobility behaviors (score) were measured." | 1.37 | Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. ( Bijjem, KR; Kaur, S; Sharma, PL, 2011) |
| "Mechanical allodynia and thermal hyperalgesia induced by CCI were markedly attenuated by celecoxib from 5 to 14 days after surgery, and relieved by ibuprofen treatment from 7 to 10 days after surgery." | 1.36 | Cyclooxygenase inhibitors suppress the expression of P2X(3) receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats. ( Guo, QL; Huang, CS; Wang, Y; Yan, JQ; Zhang, X; Zou, WY, 2010) |
"Both allodynia (PWT | 1.35 | Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia. ( Loomis, CW; O'Rielly, DD, 2008) | |
| "Thermal hyperalgesia was induced by mild heat injury (51 degrees C water for 20 s) which led to a 7-8 degrees C decrease of the noxious heat threshold." | 1.34 | Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model. ( Bölcskei, K; Horváth, D; Petho, G; Szolcsányi, J, 2007) |
| "Mechanical allodynia and thermal hyperalgesia were evaluated in 108 Wistar rats allocated to: (1-4) NaCl 0." | 1.33 | Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. ( Beaulieu, P; Guindon, J, 2006) |
| "Ibuprofen treatment reversed PGE2 levels in injured nerves and DRG, whereas celecoxib blocked increased PGE2 levels only in nerves." | 1.32 | Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. ( Marziniak, M; Schäfers, M; Sommer, C; Sorkin, LS; Yaksh, TL, 2004) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "We conclude that hyperalgesia associated with opioid withdrawal can be blocked by spinally administered ibuprofen, and suggest that there may be a role for spinal prostaglandins in the enhancement of nociception observed in association with the opioid abstinence syndrome." | 1.31 | The effect of spinal ibuprofen on opioid withdrawal in the rat. ( Buerkle, H; Dunbar, SA; Karamov, IG, 2000) |
| "The following observations were made: 1) Thermal hyperalgesia otherwise observed during the first 170 min was blocked in a dose-dependent manner by S(+)-ibuprofen or SC58125 administered i." | 1.30 | Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. ( Dirig, DM; Isakson, PC; Yaksh, TL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (14.29) | 18.2507 |
| 2000's | 16 (32.65) | 29.6817 |
| 2010's | 23 (46.94) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Nieto, FR | 1 |
| Cobos, EJ | 2 |
| Entrena, JM | 2 |
| Parra, A | 1 |
| García-Granados, A | 1 |
| Baeyens, JM | 1 |
| Wang, Y | 2 |
| Hu, X | 1 |
| Huang, H | 1 |
| Jin, Z | 1 |
| Gao, J | 1 |
| Guo, Y | 1 |
| Zhong, Y | 1 |
| Li, Z | 1 |
| Zong, X | 1 |
| Wang, K | 1 |
| Zhang, L | 1 |
| Liu, Z | 1 |
| Craft, RM | 1 |
| Hewitt, KA | 1 |
| Britch, SC | 1 |
| Yamaguchi, C | 1 |
| Yamamoto, D | 1 |
| Fujimaru, Y | 1 |
| Asano, T | 1 |
| Takaoka, A | 1 |
| Xin, DL | 1 |
| Hadrévi, J | 1 |
| Elliott, ME | 1 |
| Amin, M | 1 |
| Harris, MY | 1 |
| Barr-Gillespie, AE | 1 |
| Barbe, MF | 1 |
| Alexandre, C | 1 |
| Latremoliere, A | 1 |
| Ferreira, A | 1 |
| Miracca, G | 1 |
| Yamamoto, M | 1 |
| Scammell, TE | 1 |
| Woolf, CJ | 1 |
| Montilla-García, Á | 1 |
| Tejada, MÁ | 1 |
| Perazzoli, G | 1 |
| Portillo-Salido, E | 2 |
| Fernández-Segura, E | 1 |
| Cañizares, FJ | 1 |
| De Logu, F | 1 |
| Li Puma, S | 1 |
| Landini, L | 1 |
| Tuccinardi, T | 1 |
| Poli, G | 1 |
| Preti, D | 1 |
| De Siena, G | 1 |
| Patacchini, R | 1 |
| Tsagareli, MG | 1 |
| Geppetti, P | 1 |
| Nassini, R | 1 |
| Kalliomäki, J | 1 |
| Attal, N | 1 |
| Jonzon, B | 1 |
| Bach, FW | 1 |
| Huizar, K | 1 |
| Ratcliffe, S | 1 |
| Eriksson, B | 1 |
| Janecki, M | 1 |
| Danilov, A | 1 |
| Bouhassira, D | 1 |
| Tomić, MA | 2 |
| Micov, AM | 2 |
| Stepanović-Petrović, RM | 2 |
| Kovacevic, JM | 1 |
| Boškovic, BD | 1 |
| Redondo-Castro, E | 1 |
| Navarro, X | 1 |
| Gupta, D | 1 |
| Christensen, C | 1 |
| Soskin, V | 1 |
| Gris, G | 1 |
| Merlos, M | 1 |
| Vela, JM | 1 |
| Zamanillo, D | 1 |
| Wanigasekera, V | 1 |
| Mezue, M | 1 |
| Andersson, J | 1 |
| Kong, Y | 1 |
| Tracey, I | 1 |
| Saad, SS | 1 |
| Hamza, M | 2 |
| Bahr, MH | 1 |
| Masoud, SI | 2 |
| Bi, RY | 1 |
| Ding, Y | 1 |
| Gan, YH | 1 |
| Djekic, L | 1 |
| Martinovic, M | 1 |
| Stepanović-Petrović, R | 1 |
| Micov, A | 1 |
| Tomić, M | 1 |
| Primorac, M | 1 |
| El-Lithy, GM | 1 |
| El-Bakly, WM | 1 |
| Matboli, M | 1 |
| Abd-Alkhalek, HA | 1 |
| Koo, CH | 1 |
| Cho, YJ | 1 |
| Hong, DM | 1 |
| Jeon, Y | 1 |
| Kim, TK | 1 |
| O'Rielly, DD | 1 |
| Loomis, CW | 1 |
| Altis, K | 1 |
| Schmidtko, A | 1 |
| Angioni, C | 1 |
| Kuczka, K | 1 |
| Schmidt, H | 1 |
| Geisslinger, G | 3 |
| Lötsch, J | 1 |
| Tegeder, I | 1 |
| Zhang, X | 1 |
| Guo, QL | 1 |
| Zou, WY | 1 |
| Huang, CS | 1 |
| Yan, JQ | 1 |
| Huang, ZJ | 1 |
| Hsu, E | 1 |
| Li, HC | 1 |
| Rosner, AL | 1 |
| Rupert, RL | 1 |
| Song, XJ | 1 |
| Kaur, S | 1 |
| Bijjem, KR | 1 |
| Sharma, PL | 1 |
| Zhu, CZ | 1 |
| Mills, CD | 1 |
| Hsieh, GC | 1 |
| Zhong, C | 1 |
| Mikusa, J | 1 |
| Lewis, LG | 1 |
| Gauvin, D | 1 |
| Lee, CH | 1 |
| Decker, MW | 1 |
| Bannon, AW | 1 |
| Rueter, LE | 1 |
| Joshi, SK | 1 |
| Andrews, N | 1 |
| Legg, E | 1 |
| Lisak, D | 1 |
| Issop, Y | 1 |
| Richardson, D | 1 |
| Harper, S | 1 |
| Pheby, T | 1 |
| Huang, W | 1 |
| Burgess, G | 1 |
| Machin, I | 1 |
| Rice, AS | 1 |
| Yimam, M | 1 |
| Brownell, L | 1 |
| Hodges, M | 1 |
| Jia, Q | 1 |
| Seybold, VS | 1 |
| Jia, YP | 1 |
| Abrahams, LG | 1 |
| Schäfers, M | 1 |
| Marziniak, M | 1 |
| Sorkin, LS | 2 |
| Yaksh, TL | 3 |
| Sommer, C | 1 |
| Millecamps, M | 1 |
| Etienne, M | 1 |
| Jourdan, D | 1 |
| Eschalier, A | 2 |
| Ardid, D | 1 |
| Seibel, K | 1 |
| Schaffler, K | 1 |
| Reeh, P | 1 |
| Reitmeir, P | 1 |
| Jones, CK | 2 |
| Peters, SC | 2 |
| Shannon, HE | 2 |
| Jones, NG | 1 |
| Slater, R | 1 |
| Cadiou, H | 1 |
| McNaughton, P | 1 |
| McMahon, SB | 1 |
| Guindon, J | 1 |
| Beaulieu, P | 1 |
| Chassaing, C | 1 |
| Schmidt, J | 1 |
| Cardot, JM | 1 |
| Dubray, C | 1 |
| Bölcskei, K | 1 |
| Horváth, D | 1 |
| Szolcsányi, J | 1 |
| Petho, G | 1 |
| Doom, CM | 1 |
| Maruyama, KP | 1 |
| Nanigian, DB | 1 |
| Kilo, S | 1 |
| Forster, C | 2 |
| Brune, K | 1 |
| Handwerker, HO | 1 |
| Liso, PA | 1 |
| Rebuelta, M | 1 |
| San Román, J | 1 |
| Gallardo, A | 1 |
| Villar, AM | 1 |
| Petersen, KL | 1 |
| Brennum, J | 1 |
| Dahl, JB | 1 |
| Morris, VH | 1 |
| Cruwys, SC | 1 |
| Kidd, BL | 1 |
| Dirig, DM | 2 |
| Isakson, PC | 2 |
| Bickel, A | 1 |
| Dorfs, S | 1 |
| Schmelz, M | 1 |
| Uhl, W | 1 |
| Handwerker, OH | 1 |
| Southall, DM | 1 |
| Michael, LR | 1 |
| Vasko, RM | 1 |
| Dunbar, SA | 1 |
| Karamov, IG | 1 |
| Buerkle, H | 1 |
| Steen, AE | 1 |
| Reeh, PW | 1 |
| Steen, KH | 1 |
| Conway, CM | 1 |
| Svensson, C | 1 |
| Luo, ZD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| EN20-01: A 24 Week Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Moderate to Severe Knee Osteoarthritis Pain.[NCT05025787] | Phase 2 | 77 participants (Anticipated) | Interventional | 2021-10-25 | Recruiting | ||
| Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774] | 400 participants (Anticipated) | Interventional | 2022-04-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ibuprofen and Allodynia
| Article | Year |
|---|---|
Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Burns; Cross-Over Studies; Double-Blind | 1997 |
11 trials available for ibuprofen and Allodynia
| Article | Year |
|---|---|
A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response R | 2013 |
Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development.
Topics: Adult; Amines; Analgesics; Analgesics, Non-Narcotic; Brain; Capsaicin; Cyclohexanecarboxylic Acids; | 2016 |
Influence of high-dose intraoperative remifentanil with intravenous ibuprofen on postoperative morphine consumption in patients undergoing pancreaticoduodenectomy: a randomized trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Cyclooxygenase Inhibitors; Female; Humans; | 2016 |
Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Case-Control Studies; Cold Temperature; C | 2009 |
Comparison of two different preparations of ibuprofen with regard to the time course of their analgesic effect. A randomised, placebo-controlled, double-blind cross-over study using laser somatosensory evoked potentials obtained from UW-irritated skin in
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Cross-Over Studies; Doubl | 2004 |
Hyperalgesia induced by cutaneous freeze injury for testing analgesics in healthy volunteers.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Area | 2006 |
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man.
Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Dermatitis; Double-Blind Method; Female; | 1995 |
Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Burns; Cross-Over Studies; Double-Blind | 1997 |
Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsaicin; Dose-Response Rela | 1997 |
Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diuresis; Double-Bli | 1998 |
Plasma levels after peroral and topical ibuprofen and effects upon low pH-induced cutaneous and muscle pain.
Topics: Acidosis; Acids; Administration, Cutaneous; Administration, Oral; Adult; Anti-Inflammatory Agents, N | 2000 |
38 other studies available for ibuprofen and Allodynia
| Article | Year |
|---|---|
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular | 2013 |
Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
Topics: Analgesics; Animals; Anoctamin-1; Carboxylic Acids; HEK293 Cells; Humans; Hyperalgesia; Mice; Neopla | 2022 |
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dos | 2021 |
Acetaminophen Exerts an Analgesic Effect on Muscular Hyperalgesia in Repeated Cold-Stressed Rats through the Enhancement of the Descending Pain Inhibitory System Involving Spinal 5-HT
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cold Temperature; Cold-Shock Response; Cyclooxygen | 2021 |
Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task.
Topics: Aggression; Analgesics, Non-Narcotic; Animals; Biomarkers; Brain; Conservative Treatment; Cumulative | 2017 |
Decreased alertness due to sleep loss increases pain sensitivity in mice.
Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas | 2017 |
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.
Topics: Acetaminophen; Analgesics; Animals; Arthritis; Celecoxib; Disease Models, Animal; Diterpenes; Female | 2017 |
The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cell Line; Dinoprostone; Epit | 2019 |
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr | 2013 |
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce | 2014 |
Chronic ibuprofen administration reduces neuropathic pain but does not exert neuroprotection after spinal cord injury in adult rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Binding Proteins; Evoked Potentials, Motor | 2014 |
Marked variability in peri-partum anesthetic management of patients on buprenorphine maintenance therapy (BMT): can there be an underlying acute opioid induced hyperalgesia precipitated by neuraxial opioids in BMT patients?
Topics: Acetaminophen; Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Buprenorphine; Cesarea | 2013 |
S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, A | 2014 |
Nitric oxide is involved in ibuprofen preemptive analgesic effect in the plantar incisional model of postsurgical pain in mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Arginine; Hindlimb; Hyperalgesia; Ibup | 2016 |
Non-steroidal Anti-inflammatory Drugs Attenuate Hyperalgesia and Block Upregulation of Trigeminal Ganglionic Sodium Channel 1.7 after Induction of Temporomandibular Joint Inflammation in Rats.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; D | 2016 |
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; | 2016 |
Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; D | 2016 |
Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia.
Topics: Analysis of Variance; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-R | 2008 |
Cyclooxygenase inhibitors suppress the expression of P2X(3) receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats.
Topics: Animals; Celecoxib; Constriction, Pathologic; Cyclooxygenase Inhibitors; Ganglia, Spinal; Hot Temper | 2010 |
Topical application of compound Ibuprofen suppresses pain by inhibiting sensory neuron hyperexcitability and neuroinflammation in a rat model of intervertebral foramen inflammation.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Disease Models, An | 2011 |
Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose | 2011 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima | 2012 |
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec | 2012 |
Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechin; Edema; Flavonoids; For | 2012 |
Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation.
Topics: Action Potentials; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cyclooxygenase 2; Dose-Resp | 2003 |
Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat.
Topics: Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase | 2004 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Age | 2005 |
Acid-induced pain and its modulation in humans.
Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammator | 2004 |
Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, | 2006 |
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2007 |
Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Dose-Response Rela | 2007 |
Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase.
Topics: Animals; Behavior, Animal; Burns; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Diltiazem; En | 2008 |
Polymeric drugs derived from ibuprofen with improved antiinflammatory profile.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; | 1996 |
Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 1998 |
Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclooxygenase Inhibitors; Freund's Adj | 1998 |
The effect of spinal ibuprofen on opioid withdrawal in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Hyperalgesia; Ibuprofen; Injecti | 2000 |
The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase | 2001 |