pd 98059 has been researched along with Allodynia in 15 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental colitis has been shown to trigger bladder hyperactivity and hyperalgesia in rats." | 1.72 | Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization. ( Dong, X; Li, L; Lu, Q; Xu, J; Yang, Z; Yi, S; Zhang, H; Zhao, J; Zhu, J, 2022) |
| "Morphine-induced hyperalgesia is a pharmacological phenomenon often hindering its prolonged applications in the clinic." | 1.42 | Inhibition of spinal ERK1/2-c-JUN signaling pathway counteracts the development of low doses morphine-induced hyperalgesia. ( Galeotti, N; Ghelardini, C; Mello, T; Sanna, MD, 2015) |
| "Furthermore, G-CSF-induced hyperalgesia was inhibited in a dose-dependent manner by intrathecal pre-treatment with ERK (PD98059), JNK (SB600125), p38 (SB202190) or PI(3)K (wortmanin) inhibitors." | 1.37 | Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice. ( Batistela, AP; Carvalho, TT; Cunha, FQ; Cunha, TM; Ferreira, SH; Flauzino, T; Otaguiri, ES; Verri, WA; Zarpelon, AC, 2011) |
| "However, in the late phase of postoperative pain, ERK activation in the ACC is only required for the expression of pain-related anxiety but not mechanical hypersensitivity." | 1.37 | Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical hypersensitivity in rats after incision. ( Dai, RP; Li, CQ; Li, F; Shi, XD; Zhang, JW; Zhang, JY; Zhou, XF, 2011) |
| "We examined the air-puff thresholds (mechanical allodynia), scores of pinprick (mechanical hyperalgesia), and face grooming frequency for acetone application (hypersensitivity for cold stimulation) - 3, 3, 6, 9, 12, 15, 20, 25, 30, and 40 days after surgery." | 1.34 | Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats. ( Ahn, DK; Han, SR; Jeon, HJ; Ju, JS; Lee, MK; Lim, EJ; Yang, GY, 2007) |
| "In these studies, carrageenan-induced thermal hyperalgesia was evaluated in the mouse and the role of NGF and the MAPK pathway investigated." | 1.31 | Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway. ( Bingham, S; Davey, PT; Parsons, AA; Raval, P; Rogers, D; Sammons, MJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Dong, X | 1 |
| Yang, Z | 1 |
| Zhao, J | 1 |
| Lu, Q | 1 |
| Zhu, J | 1 |
| Li, L | 1 |
| Yi, S | 1 |
| Xu, J | 1 |
| Maruta, T | 1 |
| Nemoto, T | 1 |
| Hidaka, K | 1 |
| Koshida, T | 1 |
| Shirasaka, T | 1 |
| Yanagita, T | 1 |
| Takeya, R | 1 |
| Tsuneyoshi, I | 1 |
| Yoon, SY | 1 |
| Kwon, SG | 1 |
| Kim, YH | 1 |
| Yeo, JH | 1 |
| Ko, HG | 1 |
| Roh, DH | 1 |
| Kaang, BK | 1 |
| Beitz, AJ | 1 |
| Lee, JH | 1 |
| Oh, SB | 1 |
| Tabata, M | 1 |
| Terayama, R | 1 |
| Maruhama, K | 1 |
| Iida, S | 1 |
| Sugimoto, T | 1 |
| van den Heuvel, I | 1 |
| Reichl, S | 1 |
| Segelcke, D | 1 |
| Zahn, PK | 1 |
| Pogatzki-Zahn, EM | 1 |
| Sanna, MD | 1 |
| Mello, T | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Chen, HS | 1 |
| He, X | 1 |
| Qu, F | 1 |
| Kang, SM | 1 |
| Yu, Y | 1 |
| Liao, D | 1 |
| Lu, SJ | 1 |
| Carvalho, TT | 1 |
| Flauzino, T | 1 |
| Otaguiri, ES | 1 |
| Batistela, AP | 1 |
| Zarpelon, AC | 1 |
| Cunha, TM | 1 |
| Ferreira, SH | 1 |
| Cunha, FQ | 1 |
| Verri, WA | 1 |
| Lee, Y | 1 |
| Pai, M | 1 |
| Brederson, JD | 1 |
| Wilcox, D | 1 |
| Hsieh, G | 1 |
| Jarvis, MF | 1 |
| Bitner, RS | 1 |
| Dai, RP | 1 |
| Li, CQ | 1 |
| Zhang, JW | 1 |
| Li, F | 1 |
| Shi, XD | 1 |
| Zhang, JY | 1 |
| Zhou, XF | 1 |
| Honda, K | 2 |
| Noma, N | 1 |
| Shinoda, M | 2 |
| Miyamoto, M | 1 |
| Katagiri, A | 2 |
| Kita, D | 1 |
| Liu, MG | 2 |
| Sessle, BJ | 1 |
| Yasuda, M | 1 |
| Iwata, K | 2 |
| Matsuura, S | 1 |
| Suzuki, I | 1 |
| Shibuta, K | 1 |
| Tamagawa, T | 1 |
| Kiyomoto, M | 1 |
| Ohara, K | 1 |
| Furukawa, A | 1 |
| Urata, K | 1 |
| Sung, B | 1 |
| Lim, G | 1 |
| Mao, J | 1 |
| Lim, EJ | 1 |
| Jeon, HJ | 1 |
| Yang, GY | 1 |
| Lee, MK | 1 |
| Ju, JS | 1 |
| Han, SR | 1 |
| Ahn, DK | 1 |
| Sammons, MJ | 1 |
| Raval, P | 1 |
| Davey, PT | 1 |
| Rogers, D | 1 |
| Parsons, AA | 1 |
| Bingham, S | 1 |
15 other studies available for pd 98059 and Allodynia
| Article | Year |
|---|---|
Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization.
Topics: Animals; Benzylamines; Colitis; Cyclams; Disease Models, Animal; Extracellular Signal-Regulated MAP | 2022 |
Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Extracellular Signal-Regulated M | 2019 |
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agon | 2017 |
Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury.
Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hyperalgesi | 2018 |
Selective prevention of mechanical hyperalgesia after incision by spinal ERK1/2 inhibition.
Topics: Animals; Flavonoids; Hyperalgesia; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kina | 2015 |
Inhibition of spinal ERK1/2-c-JUN signaling pathway counteracts the development of low doses morphine-induced hyperalgesia.
Topics: Animals; Behavior, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hyperalgesia; JNK | 2015 |
Differential roles of peripheral mitogen-activated protein kinase signal transduction pathways in bee venom-induced nociception and inflammation in conscious rats.
Topics: Animals; Bee Venoms; Behavior, Animal; Enzyme Inhibitors; Flavonoids; Hyperalgesia; Imidazoles; Infl | 2009 |
Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice.
Topics: Androstadienes; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Granulocyt | 2011 |
Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.
Topics: Animals; Behavior, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hyperalgesia; Imm | 2011 |
Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical hypersensitivity in rats after incision.
Topics: Animals; Anxiety; Behavior, Animal; Blotting, Western; Butadienes; Enzyme Activation; Enzyme Inhibit | 2011 |
Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Face; Flavonoids; Hyperalgesia; Male; MAP Kinase Kina | 2011 |
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato | 2012 |
Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
Topics: Amino Acid Transport System X-AG; Animals; Behavior, Animal; Biological Transport; Carbazoles; Const | 2003 |
Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats.
Topics: Animals; Behavior, Animal; Body Weight; Constriction; Disease Models, Animal; Dose-Response Relation | 2007 |
Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway.
Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; | 2000 |