Page last updated: 2024-10-30

losartan and Allodynia

losartan has been researched along with Allodynia in 8 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Research Excerpts

ExcerptRelevanceReference
"Losartan prevented visceral allodynia and colonic hyperpermeability in rat IBS models."7.96Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome. ( Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2020)
" Delayed exercise after complex orthopaedic trauma results in decreased muscle fibrosis and improved pain Losartan, an angiotensin-receptor blocker with anti-fibrotic abilities, recapitulates the effect of exercise on post-injury recovery and may provide an enhanced recovery option for those who are unable to exercise after injury ABSTRACT: Chronic pain and disability after limb injury are major public health problems."3.96Angiotensin receptor blockade mimics the effect of exercise on recovery after orthopaedic trauma by decreasing pain and improving muscle regeneration. ( Clark, JD; Forman, TE; Goodman, SB; Paine, P; Pajarinen, J; Quarta, M; Rando, TA; Takemura, Y; Tawfik, VL, 2020)
"Losartan prevented visceral allodynia and colonic hyperpermeability in rat IBS models."3.96Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome. ( Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2020)
" Spontaneous and evoked pain behaviors were assessed before and after acute and chronic administration of Ang-(1-7)."1.43Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain. ( Arnold, MR; Forte, BL; Hay, M; Largent-Milnes, TM; Slosky, LM; Staatz, WD; Vanderah, TW; Zhang, H, 2016)
"Treatment with losartan decreased neutrophil recruitment, hypernociception and the production of TNF-α, IL-1β and chemokine (C-X-C motif) ligand 1 in mice subjected to AIA."1.39Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis. ( Bader, M; Barroso, LC; Coelho, FM; Costa, VV; Oliveira, ML; Queiroz-Junior, CM; Santos, RA; Silva, AC; Silva, TA; Silveira, KD; Sousa, LF; Teixeira, MM; Vieira, AT, 2013)
"This hyperalgesia was significantly attenuated by local administration of the AT(1) antagonist losartan."1.35Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia. ( Albino-Teixeira, A; Marques-Lopes, J; Morato, M; Patinha, D; Pinho, D; Pinto, M; Tavares, I, 2009)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's4 (50.00)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Tawfik, VL1
Quarta, M1
Paine, P1
Forman, TE1
Pajarinen, J1
Takemura, Y1
Goodman, SB1
Rando, TA1
Clark, JD1
Nozu, T1
Miyagishi, S1
Nozu, R1
Takakusaki, K1
Okumura, T1
Hong, Y1
Wu, W1
Wang, S1
Hao, Q1
Zheng, H1
Li, S1
Zhang, X1
Sun, R1
Kalynovska, N1
Diallo, M1
Palecek, J1
Kim, E1
Hwang, SH1
Kim, HK2
Abdi, S1
Silveira, KD1
Coelho, FM1
Vieira, AT1
Barroso, LC1
Queiroz-Junior, CM1
Costa, VV1
Sousa, LF1
Oliveira, ML1
Bader, M1
Silva, TA1
Santos, RA1
Silva, AC1
Teixeira, MM1
Forte, BL1
Slosky, LM1
Zhang, H1
Arnold, MR1
Staatz, WD1
Hay, M1
Largent-Milnes, TM1
Vanderah, TW1
Marques-Lopes, J1
Pinto, M1
Pinho, D1
Morato, M1
Patinha, D1
Albino-Teixeira, A1
Tavares, I1

Other Studies

8 other studies available for losartan and Allodynia

ArticleYear
Angiotensin receptor blockade mimics the effect of exercise on recovery after orthopaedic trauma by decreasing pain and improving muscle regeneration.
    The Journal of physiology, 2020, Volume: 598, Issue:2

    Topics: Angiotensin Receptor Antagonists; Animals; Fibrosis; Fractures, Bone; Hyperalgesia; Losartan; Mice;

2020
Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.
    Neurogastroenterology and motility, 2020, Volume: 32, Issue:6

    Topics: Animals; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Hyperalgesia; Irritable Bow

2020
Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord.
    Neuropharmacology, 2021, 09-15, Volume: 196

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Astrocytes; Chronic Pain; Hippocam

2021
Losartan treatment attenuates the development of neuropathic thermal hyperalgesia induced by peripheral nerve injury in rats.
    Life sciences, 2019, Mar-01, Volume: 220

    Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Losartan; Male; Neuralgia; Pain Meas

2019
Losartan, an Angiotensin II Type 1 Receptor Antagonist, Alleviates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain by Inhibiting Inflammatory Cytokines in the Dorsal Root Ganglia.
    Molecular neurobiology, 2019, Volume: 56, Issue:11

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cytokines; Disease Models, Animal; Ganglia, Spinal

2019
Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis.
    Peptides, 2013, Volume: 46

    Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Stero

2013
Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain.
    Pain, 2016, Volume: 157, Issue:12

    Topics: Analgesics; Analysis of Variance; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensi

2016
Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia.
    Neuroscience, 2009, Feb-18, Volume: 158, Issue:4

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cholera Toxin; Hyp

2009