Page last updated: 2024-10-31

neostigmine and Allodynia

neostigmine has been researched along with Allodynia in 7 studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Research Excerpts

ExcerptRelevanceReference
"Sprague-Dawley rats were used to test the analgesic effect of pentazocine and neostigmine using the paw formalin pain model and the incision mechanical allodynia model."8.12Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats. ( Bai, X; Guo, J; Huang, H; Ouyang, H; Wu, S; Zhang, K, 2022)
"Sprague-Dawley rats were used to test the analgesic effect of pentazocine and neostigmine using the paw formalin pain model and the incision mechanical allodynia model."4.12Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats. ( Bai, X; Guo, J; Huang, H; Ouyang, H; Wu, S; Zhang, K, 2022)
" Two hours later (T1), both hindpaws were tested for inflammation (paw circumference) and for hyperalgesia (paw withdrawal threshold) and subsequently 20 microg of neostigmine was injected in the right hind paw."3.71Lack of peripheral analgesia mediated by intraplantar administration of neostigmine in carrageenan-injected rats. ( Benhamou, D; Bouaziz, H; Fletcher, D; Gentili, ME; Girard, F; Laxenaire, MC; Mazoit, JX, 2001)
"On the other hand, in the presence of neuropathic pain, atropine (300 μg) did not alter the nociceptive threshold induced by constriction of the sciatic nerve."1.37Peripheral control of inflammatory but not neuropathic pain by endogenous cholinergic system. ( Alves, DP; Duarte, ID; Motta, PG; Perez, AC, 2011)
"Pretreatment with atropine (0."1.33Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury. ( Honda, M; Ono, H; Takasu, K; Tanabe, M, 2006)
"0 microg) were administered to obtain the dose-response curve and the 50% effective dose (ED(50))."1.31The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury. ( Choi, IC; Han, SM; Hwang, JH; Hwang, KS; Kim, JU; Park, PH, 2001)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Huang, H1
Bai, X1
Zhang, K1
Guo, J1
Wu, S1
Ouyang, H1
Kanashiro, A1
Talbot, J1
Peres, RS1
Pinto, LG1
Bassi, GS1
Cunha, TM1
Cunha, FQ1
Motta, PG1
Perez, AC1
Alves, DP1
Duarte, ID1
Patil, CS1
Jain, NK1
Singh, VP1
Kulkarni, SK1
Takasu, K1
Honda, M1
Ono, H1
Tanabe, M1
Bouaziz, H1
Gentili, ME1
Girard, F1
Mazoit, JX1
Benhamou, D1
Laxenaire, MC1
Fletcher, D1
Hwang, JH1
Hwang, KS1
Kim, JU1
Choi, IC1
Park, PH1
Han, SM1

Other Studies

7 other studies available for neostigmine and Allodynia

ArticleYear
Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.
    Pain research & management, 2022, Volume: 2022

    Topics: Analgesics; Animals; Atropine Derivatives; Clonidine; Formaldehyde; Humans; Hyperalgesia; Naloxone;

2022
Neutrophil Recruitment and Articular Hyperalgesia in Antigen-Induced Arthritis are Modulated by the Cholinergic Anti-Inflammatory Pathway.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 119, Issue:5

    Topics: Animals; Antigens; Arthritis, Experimental; Arthritis, Rheumatoid; Atropine Derivatives; Cholinergic

2016
Peripheral control of inflammatory but not neuropathic pain by endogenous cholinergic system.
    Pharmacology, 2011, Volume: 88, Issue:1-2

    Topics: Animals; Atropine; Carrageenan; Cholinergic Agents; Cholinesterase Inhibitors; Dinoprostone; Disease

2011
Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
    Indian journal of experimental biology, 2004, Volume: 42, Issue:4

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Acetylcholine; Animals; Carrageenan; Cholinergic A

2004
Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.
    British journal of pharmacology, 2006, Volume: 148, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Amines; Analgesics; Animals; Atropine; Cholinesterases; Cyc

2006
Lack of peripheral analgesia mediated by intraplantar administration of neostigmine in carrageenan-injected rats.
    European journal of anaesthesiology, 2001, Volume: 18, Issue:5

    Topics: Analgesics; Animals; Carrageenan; Cholinesterase Inhibitors; Foot; Hyperalgesia; Inflammation; Injec

2001
The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:5

    Topics: Animals; Baclofen; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; G

2001